STK11 Gene
protein-coding GIFtS: 70
GCID: GC19P001205
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serine/threonine kinase 11(Previous name: serine/threonine kinase 11 (Peutz-Jeghers syndrome) )
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Aliases
for STK11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Threonine Kinase 111 2 | | EC 2.7.11.13 8 | | LKB11 2 3 5 | | Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome)1 | | PJS1 2 3 5 | | Polarization-Related Protein LKB12 | | Liver Kinase B12 3 | | Serine/Threonine-Protein Kinase 112 | | Renal Carcinoma Antigen NY-REN-192 3 | | Serine/Threonine-Protein Kinase LKB12 | | HLKB11 | | Serine/Threonine-Protein Kinase STK112 |
Export aliases for STK11 gene to outside databasesPrevious GC identifers: GC19P001264 GC19P001117 GC19P001157 GC19P001156 GC19P000982 |
Summaries
for STK11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STK11:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as atumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominantdisorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth,and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not beenthoroughly characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831Function: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase(AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosisand DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote theiractivity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 andSNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a keyupstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2:it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levelsare low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-celldifferentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity byremodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation andactivation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response:interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able tophosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirectand mediated by downstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis viainteraction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosispathways
Gene Wiki entry for STK11
|
Genomic Views
for STK11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STK11 gene promoter:
COUP-TF1 p53 COUP MyoD HNF-4alpha2 HNF-4alpha1 COUP-TF STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for STK11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3STK11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001205: view genomic region
(about GC identifiers)
Start:
|
1,189,406 bp from pter |
End:
|
1,228,434 bp from pter |
Size:
|
39,029 bases |
Orientation:
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plus strand |
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Proteins
for STK11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase STK11 Size: 433 amino acids; 48636 Da
Cofactor: Magnesium or Manganese
Subunit: Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalyticactivity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with p53/TP53, SMAD4,STK11IP and WDR6
Subcellular location: Nucleus. Cytoplasm. Membrane (By similarity). Mitochondrion. Note=A small fraction localizes atmembranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25(CAB39/MO25alpha or CAB39L/MO25beta). Translocates to mitochondrion during apoptosis
1 PDB 3D structure from  and Proteopedia  for STK11:2WTK (3D)
Secondary accessions: B2RBX7 E7EW76Alternative splicing: 2 isoforms: Q15831-1 Q15831-2 Explore the universe of human proteins at neXtProt for STK11: NX_Q15831
Post-translational modifications:
Phosphorylated by ATM at Thr-363 following ionizing radiations (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or somePKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization tomediate phosphorylation of BRSK1 and BRSK2 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15831
4/6 DME Specific Peptides for STK11 (Q15831) (see all 6)
STK11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000446.1
ENSEMBL proteins: ENSP00000324856 ENSP00000466610 ENSP00000467912 ENSP00000467240 Reactome Protein details: Q15831
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
STK11 for ontologies About GeneDecksing
STK11 Antibody Products:
Assay Products for STK11: |
Protein
Domains /
Families
for STK11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STK11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q15831ProtoNet protein and cluster: Q15831 UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for STK11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831Function: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase(AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosisand DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote theiractivity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 andSNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a keyupstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2:it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levelsare low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-celldifferentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity byremodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation andactivation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response:interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able tophosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirectand mediated by downstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis viainteraction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosispathwaysCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by forming a complex with STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha orCAB39L/MO25beta): STRADA (or STRADB)-binding promotes a conformational change of STK11/LKB1 in an active conformation,which is stabilized by CAB39/MO25alpha (or CAB39L/MO25beta) interacting with the STK11/LKB1 activation loop Genatlas biochemistry entry for STK11:serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopusearly embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided coloncarcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role inthe development of ovarian carcinoma
Enzyme Number (IUBMB): EC 2.7.11.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STK11 (NM_000455) | |  | Sino Biological Human cDNA Clone for STK11 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK11 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
STK11 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for STK11:
Animal Models:
Mouse knock-outs for STK11: Stk11tm1Tpm Stk11tm1.1Mlfr Stk11tm1.3Mlfr Stk11tm2.1Tpm Stk11tm1Mmt Stk11tm1.1Jish
Stk11tm1.2Rdp
15/22 MGI mutant phenotypes (inferred from 14 alleles ) (MGI details for Stk11) (see all 22):
STK11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STK11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Development_Leptin signaling via PI3K-dependent pathway | | | 3 | Energy dependent regulation of mTOR by LKB1-AMPK | | | 4 | Integrated Pancreatic Cancer Pathway | | | 5 | mTOR signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for STK11
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STK11
1 
Cell Signaling Technology (CST) Pathway for STK11
1  GeneGo (Thomson Reuters) Pathway for STK11
5/6  BioSystems Pathways for STK11 (see all 6)
5/16 
Reactome Pathways for STK11 (see all 16)
1  PharmGKB Pathway for STK11
2 
Kegg Pathways (Kegg details for STK11):
STK11 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STK11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/367 Interacting proteins for STK11 (Q158311, 2, 3 ENSP000003248564) via UniProtKB, MINT, STRING, and/or I2D (see all 367)About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001558 | regulation of cell growth |
ISS | -- | | GO:0001894 | tissue homeostasis |
IEA | -- | | GO:0001934 | positive regulation of protein phosphorylation |
-- | -- | | GO:0001944 | vasculature development |
ISS | -- | | GO:0006112 | energy reserve metabolic process |
TAS | -- |
STK11 for ontologies About GeneDecksing
|
Drugs & Compounds
for STK11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STK11 for compounds About GeneDecksing
 Browse Tocris compounds for STK11
5 HMDB Compounds for STK11 About this table
10/23 Novoseek chemical compound relationships for STK11 gene (see all 23) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
77.5 |
73 |
10642527 (2), 10353780 (1), 10676634 (1), 14970844 (1) (see all 57) |
| phenformin |
73.8 |
3 |
14511394 (1), 14976552 (1) |
| serine |
67.5 |
70 |
10642527 (2), 10676634 (1), 14970844 (1), 15186763 (1) (see all 55) |
| rapamycin |
67.4 |
9 |
17028174 (1), 17986859 (1), 16505118 (1), 18387000 (1) (see all 8) |
| acadesine |
59.2 |
3 |
14511394 (1), 16880506 (1) |
| aicar |
58.4 |
5 |
19407487 (2), 17617058 (1), 14976552 (1), 17212587 (1) |
| metformin |
53.1 |
21 |
18250273 (8), 18000088 (2), 18681789 (2), 16530014 (1) (see all 6) |
| acetyl-coa |
51.7 |
1 |
18460326 (1), 17521700 (1) |
| atp |
31.6 |
14 |
19513107 (4), 15516847 (1), 16644800 (1), 19268526 (1) (see all 8) |
| fatty acid |
29.8 |
5 |
16644805 (3), 19459711 (1), 15769985 (1) |
Search CenterWatch for drugs/clinical trials and news about STK11
|
Transcripts
for STK11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STK11 gene: NM_000455.4 Unigene Cluster for STK11: Serine/threonine kinase 11 Hs.515005 [show with all ESTs]Unigene Representative Sequence: NM_0004559 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000585748 ENST00000326873(uc002lrl.1) ENST00000593219 ENST00000589152
ENST00000585851 ENST00000586358 ENST00000591133 ENST00000586243 ENST00000585465
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STK11 (NM_000455) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STK11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK11 |
Additional cDNA sequence: AF035625.1 AF217978.1 AJ844634.2 AK314858.1 BC007981.2 BC019334.1 EF644172.1 GU573916.1 U63333.1 11 DOTS entries: DT.112852 DT.438603 DT.95150437 DT.95150675 DT.95217327 DT.100782309 DT.121472451 DT.97847410 DT.121472474 DT.121472478 DT.92430826 24/277 AceView cDNA sequences (see all 277): BC019334 BM023142 BQ774588 AU143456 BU181506 BF064034 BE223009 AI638754 BM707767 BC007981 BX279885 AW015558 AA723245 BQ059058 BQ027193 AI218621 BI826008 BM127528 BG057000 BQ186116 AF035625 AI653599 U63333 AW006488
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for STK11 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STK11
|
Expression
for STK11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STK11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCGCCACC
About this image
See STK11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STK11
SOURCE GeneReport for Unigene cluster: Hs.515005
UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver
SABiosciences Expression via Pathway-Focused PCR Arrays including STK11:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STK11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STK11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STK11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK11 |
Orthologs
for STK11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STK11 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for STK11 (if available)
TreeFam Gene Tree for STK11 (if available) |
Paralogs
for STK11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STK11 gene
- TSSK1B2 PRKAA22 HUNK2 TSSK62 PRKAA12 TSSK32 MELK2 TSSK22
- TSSK42
18/207 SIMAP similar genes for STK11 using alignment to 7 protein entries: STK11_HUMAN (see all proteins)
(see all similar genes):CCRK MAPK8 CSNK1D CDK2 PDPK1 CAMK1
STK38L MAP4K5 CAMKK1 EIF2AK1 BRSK2 CAMKK2
MAP3K2 MAP3K3 OXSR1 PHKG2 CDK3 ADRBK1
STK11 for paralogs About GeneDecksing
|
Genomic Variants
for STK11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STK11 (1189406 - 1228434 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for STK11
4 CNVs: 30057 4066 29684 30885
Human Gene Mutation Database (HGMD): STK11
| 5/23 SABiosciences Cancer Mutation PCR Assays for STK11 (see all 23): |
| 5/9 SABiosciences Cancer Mutation PCR Arrays containing STK11 (see all 9): |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing STK11: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK11 |
|
Disorders
/ Diseases
for STK11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STK11 for disorders About GeneDecksing
OMIM gene information: 602216
OMIM disorders: 175200 273300
UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831
Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease inwhich there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominantdisorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and anincreased risk for various neoplasms, including gastrointestinal cancer Defects in STK11 have been associated with testicular germ cell tumor (TGCT) [MIM:273300]. A common solidmalignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms Note=Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently mutatedand inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process, especially lungcancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate into squamous cellcarcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and non-cancer-cellautonomous mechanisms
20/86  diseases for STK11 (see all 86): About MalaCardspeutz-jeghers syndrome bannayan-riley-ruvalcaba syndrome polyhydramnios, megalencephaly, and symptomatic epilepsy renal carcinoma
carcinoma familial adenomatous polyposis testicular tumor, sporadic melanoma, malignant sporadic
juvenile polyposis syndrome germ cell tumor long qt syndrome megalencephaly
testicular germ cell tumor male germ cell tumor carney complex cowden disease
intussusception pancreatic cancer, sporadic ataxia telangiectasia polyhydramnios
3 diseases from the University of Copenhagen DISEASES database for STK11:Peutz-Jeghers syndrome Lung cancer Carcinoma 10/58 Novoseek disease relationships for STK11 gene (see all 58) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| peutz-jeghers syndrome |
98.3 |
169 |
16407375 (3), 11832000 (3), 10090485 (3), 10353780 (2) (see all 99) |
| polyposis |
85.4 |
22 |
11956081 (2), 10398133 (1), 12506466 (1), 18600394 (1) (see all 19) |
| germ-line mutation |
77.6 |
24 |
11956081 (2), 11103790 (2), 9850045 (2), 9537235 (1) (see all 17) |
| polyps |
77.4 |
68 |
11103790 (5), 20423848 (3), 11956081 (3), 20020146 (3) (see all 34) |
| hamartoma |
74.8 |
41 |
11956081 (6), 16278673 (4), 12183403 (2), 9708796 (2) (see all 19) |
| somatic mutations |
73.2 |
32 |
11103790 (3), 10079245 (3), 9537235 (2), 9605748 (2) (see all 19) |
| cowden disease |
72.1 |
6 |
18598780 (1), 11595829 (1), 10381580 (1), 15987703 (1) (see all 5) |
| juvenile polyposis syndrome |
71.5 |
1 |
10740625 (1) |
| cancer |
61.8 |
150 |
16407375 (6), 15188174 (5), 10398133 (3), 17599048 (3) (see all 79) |
| adenocarcinoma lung |
59.1 |
16 |
17521700 (3), 12912948 (2), 15077168 (2), 15021901 (2) (see all 12) |
GeneTests: STK11
Peutz-Jeghers Syndrome
Genetic Association Database (GAD): STK11
Human Genome Epidemiology (HuGE) Navigator: STK11 (31 documents)
Export disorders for STK11 gene to outside databases
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Publications
for STK11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for STK11 gene, integrated from 9 sources (see all 451):
(articles sorted by number of sources associating them with STK11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. (PubMed id 9425897)1, 2, 3 Jenne D.E.... Zimmer M. (1998)
- LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. (PubMed id 17108107)1, 2, 9 Zeng P.Y. and Berger S.L. (2006)
- Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2, 9 Jaleel M....Alessi D.R. (2005)
- LKB1 gene mutations in Japanese lung cancer patients. (PubMed id 17711506)1, 2, 9 Onozato R....Mitsudomi T. (2007)
- Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. (PubMed id 18594528)1, 2, 9 Koivunen J.P....Janne P.A. (2008)
- Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. (PubMed id 12533684)1, 2, 9 Kuragaki C....Fujii S. (2003)
- Prevalence and specificity of LKB1 genetic alterations in lung cancers. (PubMed id 17384680)1, 2, 9 Matsumoto S....Yokota J. (2007)
- Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PubMed id 12805220)1, 2, 9 Baas A.F.... Clevers H.C. (2003)
- MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 2, 9 Boudeau J.... Alessi D.R. (2003)
- LKB1 modulates lung cancer differentiation and metastasis. (PubMed id 17676035)1, 2, 9 Ji H....Wong K.K. (2007)
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External Searches for STK11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing STK11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing STK11 gene
(According to HUGE)
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Specialized Databases showing STK11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for STK11 gene:
Search GeneIP for patents involving STK11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for STK11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for STK11 | | OriGene shRNA RFP for STK11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STK11 | | | OriGene Protein Over-expression Lysate for STK11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STK11 | | OriGene 3'-UTR Clone for STK11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STK11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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