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STK11 Gene

protein-coding   GIFtS: 73
GCID: GC19P001205

Serine/Threonine Kinase 11

(Previous name: serine/threonine kinase 11 (Peutz-Jeghers syndrome))
  See STK11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Threonine Kinase 111 2     hLKB12 3
LKB12 3 5     EC 2.7.11.13 8
PJS2 3 5     Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome)1
Polarization-Related Protein LKB11 2     Serine/Threonine-Protein Kinase 112
Liver Kinase B12 3     Serine/Threonine-Protein Kinase LKB12
Renal Carcinoma Antigen NY-REN-192 3     Serine/Threonine-Protein Kinase STK112

External Ids:    HGNC: 113891   Entrez Gene: 67942   Ensembl: ENSG000001180467   OMIM: 6022165   UniProtKB: Q158313   
ORGUL members:         

Export aliases for STK11 gene to outside databases

Previous GC identifers: GC19P001264 GC19P001117 GC19P001157 GC19P001156 GC19P000982


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK11 Gene:
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as
a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal
dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the
skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed
but have not been thoroughly characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for STK11 Gene:
STK11 (serine/threonine kinase 11) is a protein-coding gene. Diseases associated with STK11 include testicular tumor, somatic, and intussusception. GO annotations related to this gene include magnesium ion binding and identical protein binding. An important paralog of this gene is CAMKK1.

UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831
Function: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein
kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity,
apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote
their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1,
SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly
p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic
subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and
proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells
undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts
as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons
polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and
specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter
to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo
is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 Also
acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion
during apoptosis and regulates p53/TP53-dependent apoptosis pathways

Gene Wiki entry for STK11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STK11 gene promoter:
         COUP-TF1   p53   COUP   MyoD   HNF-4alpha2   HNF-4alpha1   COUP-TF   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK11 promoter sequence
   Search Chromatin IP Primers for STK11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

STK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001205:  view genomic region     (about GC identifiers)

Start:
1,189,406 bp from pter      End:
1,228,434 bp from pter
Size:
39,029 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase STK11 precursor  
Size: 433 amino acids; 48636 Da
Cofactor: Magnesium or Manganese
Subunit: Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with
p53/TP53, SMAD4, STK11IP and WDR6. Interacts with NR4A1. Interacts with NISCH; this interaction may increase
STK11 activity
1 PDB 3D structure from and Proteopedia for STK11:
2WTK (3D)    
Secondary accessions: B2RBX7 E7EW76
Alternative splicing: 2 isoforms:  Q15831-1   Q15831-2   

Explore the universe of human proteins at neXtProt for STK11: NX_Q15831

Explore proteomics data for STK11 at MOPED

Post-translational modifications: 

  • Phosphorylated by ATM at Thr-363 following ionizing radiations (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or
    some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal
    polarization to mediate phosphorylation of BRSK1 and BRSK2 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK11 (Q15831) (see all 6)
     DIWSAGV  LHSQGIVH  GSPAFQPPE  IIYTQDFTVPGQV 


    See STK11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000446.1  
    ENSEMBL proteins: 
     ENSP00000324856   ENSP00000466610   ENSP00000467912   ENSP00000467240  
    Reactome Protein details: Q15831

    STK11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for STK11

     
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    antibodies-online proteins for STK11 (7 products) 

     
    antibodies-online peptides for STK11

    STK11 Antibody Products:

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    antibodies-online antibodies for STK11 (237 products) 

    STK11 Assay Products:

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    Cloud-Clone Corp. ELISAs for STK11
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 11
    LKB subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q15831

    ProtoNet protein and cluster: Q15831

    UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with STK11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK11_HUMAN, Q15831
    Function: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein
    kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity,
    apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote
    their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1,
    SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly
    p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic
    subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and
    proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells
    undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts
    as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons
    polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and
    specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter
    to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo
    is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 Also
    acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion
    during apoptosis and regulates p53/TP53-dependent apoptosis pathways
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by forming a complex with STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or
    CAB39L/MO25beta): STRADA (or STRADB)-binding promotes a conformational change of STK11/LKB1 in an active
    conformation, which is stabilized by CAB39/MO25alpha (or CAB39L/MO25beta) interacting with the STK11/LKB1
    activation loop. Sequestration in the nucleus by NR4A1 prevents it from phosphorylating and activating
    cytoplasmic AMPK

         Genatlas biochemistry entry for STK11:
    serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of
    Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon
    carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor
    role in the development of ovarian carcinoma

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12805220
    GO:0002039p53 binding IDA11430832
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with STK11           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for STK11:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased mitotic index  Increased viability with 4OH t 
     Wnt reporter downregulated 

         Selected MGI mutant phenotypes (inferred from 15 alleles(MGI details for Stk11) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with STK11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for STK11: Stk11tm1Tpm Stk11tm1.1Mlfr Stk11tm1.3Mlfr Stk11tm2.1Tpm Stk11tm1Mmt Stk11tm1.1Jish
                                                         Stk11tm1.2Rdp

       genOway: Develop your customized and physiologically relevant rodent model for STK11

    miRNA
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    miRTarBase miRNAs that target STK11:
    hsa-mir-93-5p (MIRT028122), hsa-mir-130b-3p (MIRT020252), hsa-mir-17-5p (MIRT050817)

    Block miRNA regulation of human, mouse, rat STK11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK11 (see all 20):
    hsa-miR-142-5p hsa-miR-137 hsa-miR-330-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-3129-5p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidSTK11 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: STK11 (NM_000455)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK11
    Addgene plasmids for STK11 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK11_HUMAN, Q15831: Nucleus. Cytoplasm. Membrane (By similarity). Mitochondrion. Note=A small fraction localizes
    at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25
    (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to mitochondrion during apoptosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    cytoskeleton2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA11430832
    GO:0005739mitochondrion IDA11430832
    GO:0005829cytosol TAS--
    GO:0016020membrane ISS--

    Find genes that share ontologies with STK11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK11 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic
    AMPK inhibits chREBP transcriptional activation activity0.00
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    3Integration of energy metabolism
    Integration of energy metabolism0.75
    4Signaling by GPCR
    Signal Transduction0.58
    5p70S6K Signaling
    mTOR Pathway0.54


    Find genes that share SuperPaths with STK11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STK11
        AMPK Enzyme Complex Pathway
    Molecular Mechanisms of Cancer
    mTOR Pathway
    Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for STK11
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for STK11
        Development Leptin signaling via PI3K-dependent pathway

    5 BioSystems Pathways for STK11
        AMPK signaling
    Integrated Breast Cancer Pathway
    TGF-beta Receptor Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    LKB1 signaling events


    2 Reactome Pathways for STK11
        AMPK inhibits chREBP transcriptional activation activity
    Regulation of AMPK activity via LKB1

    1 PharmGKB Pathway for STK11
        Metformin Pathway, Pharmacodynamic

    4 Kegg Pathways  (Kegg details for STK11):
        FoxO signaling pathway
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Adipocytokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STK11: 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STK11 (Q158311, 2, 3 ENSP000003248564) via UniProtKB, MINT, STRING, and/or I2D (see all 403)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ISS--
    GO:0001894tissue homeostasis IEA--
    GO:0001944vasculature development ISS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006468protein phosphorylation IDA12805220

    Find genes that share ontologies with STK11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for STK11

    5 HMDB Compounds for STK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    Selected Novoseek inferred chemical compound relationships for STK11 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 77.5 73 10642527 (2), 10353780 (1), 10676634 (1), 14970844 (1) (see all 57)
    phenformin 73.8 3 14511394 (1), 14976552 (1)
    serine 67.5 70 10642527 (2), 10676634 (1), 14970844 (1), 15186763 (1) (see all 55)
    rapamycin 67.4 9 17028174 (1), 17986859 (1), 16505118 (1), 18387000 (1) (see all 8)
    acadesine 59.2 3 14511394 (1), 16880506 (1)
    aicar 58.4 5 19407487 (2), 17617058 (1), 14976552 (1), 17212587 (1)
    metformin 53.1 21 18250273 (8), 18000088 (2), 18681789 (2), 16530014 (1) (see all 6)
    acetyl-coa 51.7 1 18460326 (1), 17521700 (1)
    atp 31.6 14 19513107 (4), 15516847 (1), 16644800 (1), 19268526 (1) (see all 8)
    fatty acid 29.8 5 16644805 (3), 19459711 (1), 15769985 (1)



    Find genes that share compounds with STK11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STK11 gene: 
    NM_000455.4  

    Unigene Cluster for STK11:

    Serine/threonine kinase 11
    Hs.515005  [show with all ESTs]
    Unigene Representative Sequence: NM_000455
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585748 ENST00000326873(uc002lrl.1) ENST00000593219 ENST00000589152
    ENST00000585851 ENST00000586358 ENST00000591133 ENST00000586243 ENST00000585465

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    hsa-miR-142-5p hsa-miR-137 hsa-miR-330-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-3129-5p hsa-miR-519a
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    Additional mRNA sequence: 

    AF035625.1 AF217978.1 AJ844634.2 AK314858.1 BC007981.2 BC019334.1 EF644172.1 GU573916.1 
    U63333.1 

    11 DOTS entries:

    DT.112852  DT.438603  DT.95150437  DT.95150675  DT.95217327  DT.100782309  DT.121472451  DT.97847410 
    DT.121472474  DT.121472478  DT.92430826 

    Selected AceView cDNA sequences (see all 277):

    U63333 NM_000455 BQ232117 BU528185 CD673132 BI964835 BG057000 CA454330 
    BQ059058 BM818655 BQ027193 CD358468 BE223009 AI218621 BQ213255 BM127237 
    AI653599 BM552713 CD675075 AF035625 CA397512 BC007981 AI652092 CK904891 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK11 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:                          -                                                                                       
    SP2:                          -                                                                                       
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                          -                                                                                       


    ECgene alternative splicing isoforms for STK11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    STK11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGCCACC
    STK11 Expression
    About this image


    STK11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    STK11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515005

    UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831
    Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STK11: 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Prostate Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STK11 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk111 , 5 serine/threonine kinase 111, 5 85.23(n)1
    90.95(a)1
      10 (39.72 cM)5
    208691  NM_011492.31  NP_035622.11 
     801158035 
    chicken
    (Gallus gallus)
    Aves STK111 serine/threonine kinase 11 80.22(n)
    90.53(a)
      420105  NM_001045833.1  NP_001039298.1 
    lizard
    (Anolis carolinensis)
    Reptilia STK116
    serine/threonine kinase 11
    76(a)
    1 ↔ 1
    GL343942.1(30782-65340)
    African clawed frog
    (Xenopus laevis)
    Amphibia XEEK12 XEEK1 protein 77.09(n)    U24435.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj61a052 Transcribed sequence with moderate similarity to protein more 79.44(n)    BG308162.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lkb13 protein amino acid phosphorylation
    protein kinase
    61(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea par-41 par-4 47.12(n)
    42.9(a)
      180185  NM_001269850.1  NP_001256779.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOS36
    SAK16
    Protein kinase, related to and functionally redund...
    Upstream serine/threonine kinase for the SNF1 comp...
    19(a)
    10(a)
    many ↔ many
    many ↔ many
    VII(163409-165091) YGL179C
    V(417281-420709) YER129W


    ENSEMBL Gene Tree for STK11 (if available)
    TreeFam Gene Tree for STK11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK11 gene
    CAMKK12  CAMKK22  
    Selected SIMAP similar genes for STK11 using alignment to 7 protein entries:     STK11_HUMAN (see all proteins) (see all similar genes):
    CCRK    MAPK8    CSNK1D    CDK2    PDPK1    CAMK1
    STK38L    MAP4K5    CAMKK1    EIF2AK1    BRSK2    CAMKK2
    MAP3K2    MAP3K3    OXSR1    PHKG2    CDK3    ADRBK1

    Find genes that share paralogs with STK11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK11 (see all 646)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0656414
    Colorectal cancer4--see VAR_0656412 E K mis40--------
    VAR_0656524
    Sporadic cancer4--see VAR_0656522 T P mis40--------
    VAR_0656404
    Lung cancer4--see VAR_0656402 D V mis40--------
    VAR_0656304
    Sporadic cancer4--see VAR_0656302 R G mis40--------
    VAR_0656474
    Sporadic cancer4--see VAR_0656472 E V mis40--------
    VAR_0331414
    Melanoma4--see VAR_0331412 D Y mis40--------
    VAR_0656444
    Colorectal cancer4--see VAR_0656442 D N mis40--------
    VAR_0656324
    Sporadic cancer4--see VAR_0656322 F S mis40--------
    VAR_0656584
    Gastric carcinoma4--see VAR_0656582 P L mis40--------
    VAR_0656514
    Sporadic cancer4--see VAR_0656512 L R mis40--------

    HapMap Linkage Disequilibrium report for STK11 (1189406 - 1228434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STK11 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717833CNV Deletion23290073
    esv2717834CNV Deletion23290073
    dgv3589n71CNV Loss21882294
    dgv3590n71CNV Loss21882294
    dgv3586n71CNV Loss21882294
    nsv910292CNV Loss21882294
    dgv3591n71CNV Loss21882294
    dgv3593n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3575n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): STK11
    Selected Site Specific Mutation Identification with PCR Assays for STK11 (see all 23):
    Cosmic IdAA Change
    13480p.Q220*
    12924p.P281fs*6
    21212p.E57fs*7
    25851p.L282fs*3
    29468p.R304W
    Selected Site Specific Cancer Mutation PCR Panels containing STK11 (see all 9):
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Tumor Suppressor Panel 384HT
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    2 Copy Number PCR Panels containing STK11:
    Oncogenes & Tumor Suppressor Genes 384HC
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing STK11
    DNA2.0 Custom Variant and Variant Library Synthesis for STK11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602216   
    OMIM disorders: 175200  260350  273300  
    UniProtKB/Swiss-Prot: STK11_HUMAN, Q15831
  • Peutz-Jeghers syndrome (PJS) [MIM:175200]: An autosomal dominant disorder characterized by melanocytic
    macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms,
    including gastrointestinal cancer. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all
    testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell
    neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal
    carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. Note=The gene represented in this entry may be involved
    in disease pathogenesis
  • Note=Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently
    mutated and inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process,
    especially lung cancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate
    into squamous cell carcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and
    non-cancer-cell autonomous mechanisms

  • 18 diseases for STK11:    
    About MalaCards
    testicular tumor, somatic    intussusception    peutz-jeghers syndrome    melanoma, malignant, somatic
    pancreatic cancer    cowden disease    germ cell tumors    spermatocytic seminoma, somatic
    juvenile polyposis syndrome    acinar cell carcinoma    polyhydramnios    large cell carcinoma
    male germ cell tumor, somatic    carney complex    megalencephaly    tuberous sclerosis
    autosomal dominant disease    lung cancer

    4 diseases from the University of Copenhagen DISEASES database for STK11:
    Peutz-Jeghers syndrome     Lung cancer     Autosomal dominant disease     Carcinoma

    Find genes that share disorders with STK11           About GenesLikeMe

    Selected Novoseek inferred disease relationships for STK11 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peutz-jeghers syndrome 98.3 169 16407375 (3), 11832000 (3), 10090485 (3), 10353780 (2) (see all 99)
    polyposis 85.4 22 11956081 (2), 10398133 (1), 12506466 (1), 18600394 (1) (see all 19)
    germ-line mutation 77.6 24 11956081 (2), 11103790 (2), 9850045 (2), 9537235 (1) (see all 17)
    polyps 77.4 68 11103790 (5), 20423848 (3), 11956081 (3), 20020146 (3) (see all 34)
    hamartoma 74.8 41 11956081 (6), 16278673 (4), 12183403 (2), 9708796 (2) (see all 19)
    somatic mutations 73.2 32 11103790 (3), 10079245 (3), 9537235 (2), 9605748 (2) (see all 19)
    cowden disease 72.1 6 18598780 (1), 11595829 (1), 10381580 (1), 15987703 (1) (see all 5)
    juvenile polyposis syndrome 71.5 1 10740625 (1)
    cancer 61.8 150 16407375 (6), 15188174 (5), 10398133 (3), 17599048 (3) (see all 79)
    adenocarcinoma lung 59.1 16 17521700 (3), 12912948 (2), 15077168 (2), 15021901 (2) (see all 12)

    GeneTests: STK11
    GeneReviews: STK11
    Genetic Association Database (GAD): STK11
    Human Genome Epidemiology (HuGE) Navigator: STK11 (31 documents)

    Export disorders for STK11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK11 gene, integrated from 10 sources (see all 486):
    (articles sorted by number of sources associating them with STK11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LKB1 gene mutations in Japanese lung cancer patients. (PubMed id 17711506)1, 2, 4, 9 Onozato R....Mitsudomi T. (Cancer Sci. 2007)
    2. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. (PubMed id 18594528)1, 2, 4, 9 Koivunen J.P.... Janne P.A. (Br. J. Cancer 2008)
    3. Prevalence and specificity of LKB1 genetic alterations in lung cancers. (PubMed id 17384680)1, 2, 4, 9 Matsumoto S.... Yokota J. (Oncogene 2007)
    4. Spectrum of LKB1, EGFR, and KRAS mutations in Chinese lung adenocarcinomas. (PubMed id 20559149)1, 2, 4 Gao B.... Ji H. (J. Thorac. Oncol. 2010)
    5. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. (PubMed id 9425897)1, 2, 3 Jenne D.E.... Zimmer M. (Nat. Genet. 1998)
    6. LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. (PubMed id 17108107)1, 2, 9 Zeng P.Y. and Berger S.L. (Cancer Res. 2006)
    7. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2, 9 Jaleel M....Alessi D.R. (FEBS Lett. 2005)
    8. No association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population. (PubMed id 20057966)1, 4, 9 Sung J.S....Kim Y.H. (Cancer Res Treat 2009)
    9. Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. (PubMed id 12533684)1, 2, 9 Kuragaki C.... Fujii S. (Lab. Invest. 2003)
    10. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. (PubMed id 12805220)1, 2, 9 Baas A.F.... Clevers H.C. (EMBO J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6794 HGNC: 11389 AceView: STK11 Ensembl:ENSG00000118046 euGenes: HUgn6794
    ECgene: STK11 Kegg: 6794 H-InvDB: STK11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STK11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STK11 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=STK11[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/PJS

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK11 gene:
    Search GeneIP for patents involving STK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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