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Aliases for STK11 Gene

Aliases for STK11 Gene

  • Serine/Threonine Kinase 11 2 3 5
  • Polarization-Related Protein LKB1 2 3
  • Renal Carcinoma Antigen NY-REN-19 3 4
  • Liver Kinase B1 3 4
  • EC 2.7.11.1 4 58
  • HLKB1 3 4
  • LKB1 3 4
  • PJS 3 4
  • Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome) 2
  • Serine/Threonine-Protein Kinase STK11 3
  • Serine/Threonine-Protein Kinase LKB1 3
  • Serine/Threonine-Protein Kinase 11 3

External Ids for STK11 Gene

Previous GeneCards Identifiers for STK11 Gene

  • GC19P001264
  • GC19P001117
  • GC19P001157
  • GC19P001156
  • GC19P000982

Summaries for STK11 Gene

Entrez Gene Summary for STK11 Gene

  • This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

CIViC summary for STK11 Gene

GeneCards Summary for STK11 Gene

STK11 (Serine/Threonine Kinase 11) is a Protein Coding gene. Diseases associated with STK11 include Peutz-Jeghers Syndrome and Testicular Germ Cell Tumor. Among its related pathways are Metabolism and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMKK2.

UniProtKB/Swiss-Prot for STK11 Gene

  • Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

  • Isoform 2: Has a role in spermiogenesis.

Gene Wiki entry for STK11 Gene

Additional gene information for STK11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK11 Gene

Genomics for STK11 Gene

Regulatory Elements for STK11 Gene

Enhancers for STK11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H001236 1.9 FANTOM5 ENCODE dbSUPER 18.6 +79.3 79301 41 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZC3H11A SF3A2 TCF3 LOC100288123 MIER2 CIRBP TMEM259 DAZAP1 PTBP1 C19orf24 MUM1
GH19H001647 1.4 ENCODE dbSUPER 24.5 +472.9 472899 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SF3A2 TCF3 LOC100288123 DAZAP1 DOT1L TMEM259 STK11 AP3D1 MUM1 ATP8B3
GH19H001202 1.7 Ensembl ENCODE dbSUPER 19.4 +29.2 29199 7 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC MEF2D ZNF610 CIRBP TMEM259 DAZAP1 LOC100288123 TCF3 PTBP1 GRIN3B POLRMT MIER2 DOT1L
GH19H000795 1.6 Ensembl ENCODE dbSUPER 15.2 -378.3 -378252 8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 DAZAP1 TCF3 TMEM259 CIRBP STK11 MED16 PTBP1 POLRMT MIER2 RPS15
GH19H001506 1.6 Ensembl ENCODE dbSUPER 15.2 +333.0 333046 7 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF143 FOS SP3 DAZAP1 LOC100288123 SF3A2 TCF3 DOT1L TMEM259 PTBP1 STK11 POLRMT MED16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STK11 on UCSC Golden Path with GeneCards custom track

Genomic Location for STK11 Gene

Chromosome:
19
Start:
1,177,558 bp from pter
End:
1,228,435 bp from pter
Size:
50,878 bases
Orientation:
Plus strand

Genomic View for STK11 Gene

Genes around STK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK11 Gene

Proteins for STK11 Gene

  • Protein details for STK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15831-STK11_HUMAN
    Recommended name:
    Serine/threonine-protein kinase STK11
    Protein Accession:
    Q15831
    Secondary Accessions:
    • B2RBX7
    • E7EW76

    Protein attributes for STK11 Gene

    Size:
    433 amino acids
    Molecular mass:
    48636 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with p53/TP53, SMAD4, STK11IP and WDR6. Interacts with NR4A1. Interacts with NISCH; this interaction may increase STK11 activity. Interacts with PTEN; leading to PTEN phosphorylation. Interacts with SIRT1; the interaction deacetylates STK11. Interacts with CDKN1A.

    Three dimensional structures from OCA and Proteopedia for STK11 Gene

    Alternative splice isoforms for STK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STK11 Gene

Selected DME Specific Peptides for STK11 Gene

Q15831:
  • GTLKISDLGVAEALHPFA
  • IIYTQDFTVPGQV
  • DIWSAGV
  • SVGMDTFIHRIDSTEVIYQPRRKRAKL
  • GSPAFQPPE
  • LHSQGIVH

Post-translational modifications for STK11 Gene

  • Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro.
  • Phosphorylated by ATM at Thr-363 following ionizing radiation (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2 (By similarity). Phosphorylation by PKC/PRKCZ at Ser-428 promotes peroxynitrite-induced nuclear export of STK11, leading to PTEN activation and subsequent inhibition of AKT signaling. Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation-induced phosphorylation at Thr-363 mediates CDKN1A degradation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STK11 Gene

Gene Families for STK11 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q15831

UniProtKB/Swiss-Prot:

STK11_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
genes like me logo Genes that share domains with STK11: view

Function for STK11 Gene

Molecular function for STK11 Gene

GENATLAS Biochemistry:
serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forming a complex with STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): STRADA (or STRADB)-binding promotes a conformational change of STK11/LKB1 in an active conformation, which is stabilized by CAB39/MO25alpha (or CAB39L/MO25beta) interacting with the STK11/LKB1 activation loop. Sequestration in the nucleus by NR4A1 prevents it from phosphorylating and activating cytoplasmic AMPK.
UniProtKB/Swiss-Prot Function:
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
UniProtKB/Swiss-Prot Function:
Isoform 2: Has a role in spermiogenesis.

Enzyme Numbers (IUBMB) for STK11 Gene

Phenotypes From GWAS Catalog for STK11 Gene

Gene Ontology (GO) - Molecular Function for STK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12805220
GO:0002039 p53 binding IDA 11430832
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005515 protein binding IPI 12595760
genes like me logo Genes that share ontologies with STK11: view
genes like me logo Genes that share phenotypes with STK11: view

Human Phenotype Ontology for STK11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STK11 Gene

MGI Knock Outs for STK11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STK11
  • Applied Biological Materials Clones for STK11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Transcription Factor Targets and HOMER Transcription for STK11 Gene

Localization for STK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK11 Gene

Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}.
Isoform 2: Nucleus. Cytoplasm. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STK11 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 2
peroxisome 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12805220
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IDA,IEA 11430832
GO:0005739 mitochondrion IEA,IDA 11430832
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with STK11: view

Pathways & Interactions for STK11 Gene

genes like me logo Genes that share pathways with STK11: view

SIGNOR curated interactions for STK11 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for STK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth ISS --
GO:0001894 tissue homeostasis IEA --
GO:0001944 vasculature development ISS --
GO:0006468 protein phosphorylation IDA,IEA 12805220
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with STK11: view

Drugs & Compounds for STK11 Gene

(17) Drugs for STK11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
cyclic amp Experimental Pharma 0
ATP Nutra Agonist 0
Magnesium Nutra 0

(10) Additional Compounds for STK11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with STK11: view

Transcripts for STK11 Gene

Unigene Clusters for STK11 Gene

Serine/threonine kinase 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STK11
  • Applied Biological Materials Clones for STK11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for STK11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: - - - -

Relevant External Links for STK11 Gene

GeneLoc Exon Structure for
STK11
ECgene alternative splicing isoforms for
STK11

Expression for STK11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STK11 Gene

Protein differential expression in normal tissues from HIPED for STK11 Gene

This gene is overexpressed in Testis (42.6) and Urine (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STK11 Gene



Protein tissue co-expression partners for STK11 Gene

NURSA nuclear receptor signaling pathways regulating expression of STK11 Gene:

STK11

SOURCE GeneReport for Unigene cluster for STK11 Gene:

Hs.515005

mRNA Expression by UniProt/SwissProt for STK11 Gene:

Q15831-STK11_HUMAN
Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Evidence on tissue expression from TISSUES for STK11 Gene

  • Liver(4.6)
  • Lung(4.6)
  • Nervous system(4.6)
  • Muscle(3)
  • Intestine(2.7)
  • Heart(2.5)
  • Pancreas(2.5)
  • Blood(2.1)
  • Kidney(2)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STK11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • face
  • head
  • lip
  • mouth
  • nose
  • pharynx
  • pituitary gland
Thorax:
  • breast
  • esophagus
Abdomen:
  • appendix
  • biliary tract
  • duodenum
  • gallbladder
  • intestine
  • large intestine
  • liver
  • pancreas
  • small intestine
  • stomach
Pelvis:
  • anus
  • fallopian tube
  • ovary
  • penis
  • prostate
  • rectum
  • testicle
  • ureter
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • digit
  • finger
  • hand
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with STK11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STK11 Gene

Orthologs for STK11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STK11 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia STK11 33 34
  • 89.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STK11 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk11 33
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia Stk11 33 16 34
  • 85.23 (n)
oppossum
(Monodelphis domestica)
Mammalia STK11 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STK11 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK11 33
  • 80.22 (n)
lizard
(Anolis carolinensis)
Reptilia STK11 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk11 33
  • 73.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia XEEK1 33
zebrafish
(Danio rerio)
Actinopterygii stk11 33 34
  • 77.96 (n)
wufj61a05 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003158 33
  • 64.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta lkb1 35 34
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea par-4 33 34
  • 47.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOS3 34
  • 19 (a)
ManyToMany
SAK1 34
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11343 33
Species where no ortholog for STK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK11 Gene

ENSEMBL:
Gene Tree for STK11 (if available)
TreeFam:
Gene Tree for STK11 (if available)

Paralogs for STK11 Gene

Paralogs for STK11 Gene

(216) SIMAP similar genes for STK11 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with STK11: view

Variants for STK11 Gene

Sequence variations from dbSNP and Humsavar for STK11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs121913315 Pathogenic, Peutz-Jeghers syndrome (PJS) [MIM:175200], Melanoma 1,220,488(+) TCTCC(A/G/T)ACCTG nc-transcript-variant, reference, missense
rs121913316 Lung cancer 1,220,489(+) CTCCG(A/T)CCTGG nc-transcript-variant, reference, missense
rs121913317 Colorectal cancer 1,220,503(+) TGGCC(A/G/T)AGGTA nc-transcript-variant, reference, missense, stop-gained
rs121913322 Uncertain significance, Ovarian carcinoma 1,221,320(+) CCCCC(A/C/G/T)GCTCT nc-transcript-variant, reference, missense
rs137853077 other, Peutz-Jeghers syndrome (PJS) [MIM:175200] 1,207,113(+) GGTGC(C/T)GGACT nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for STK11 Gene

Variant ID Type Subtype PubMed ID
dgv136n111 CNV deletion 26073780
dgv6196n54 CNV loss 21841781
esv2717833 CNV deletion 23290073
esv2717834 CNV deletion 23290073
esv2758743 CNV gain+loss 17122850
nsv1058677 CNV loss 25217958
nsv1060536 CNV gain 25217958
nsv1160555 CNV deletion 26073780
nsv470103 CNV gain 18288195
nsv470104 CNV loss 18288195
nsv578268 CNV loss 21841781
nsv828368 CNV gain 20364138
nsv953941 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for STK11 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK11 Gene

Human Gene Mutation Database (HGMD)
STK11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK11 Gene

Disorders for STK11 Gene

MalaCards: The human disease database

(31) MalaCards diseases for STK11 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
peutz-jeghers syndrome
  • colonic hamartomatous polyp
testicular germ cell tumor
  • male germ cell tumor, somatic
pancreatic cancer
  • pancreatic carcinoma, somatic
malignant melanoma, somatic
  • dysplastic nevus syndrome
intussusception
  • intussusception nos
- elite association - COSMIC cancer census association via MalaCards
Search STK11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STK11_HUMAN
  • Note=Defects in STK11 are associated with some sporadic cancers, especially lung cancers. Frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Defects promote lung cancerigenesis process, especially lung cancer progression and metastasis. Confers lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma. Also able to promotes lung cancer metastasis, via both cancer-cell autonomous and non-cancer-cell autonomous mechanisms.
  • Peutz-Jeghers syndrome (PJS) [MIM:175200]: An autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. {ECO:0000269 PubMed:10408777, ECO:0000269 PubMed:12372054, ECO:0000269 PubMed:15987703, ECO:0000269 PubMed:21411391, ECO:0000269 PubMed:9425897, ECO:0000269 PubMed:9428765, ECO:0000269 PubMed:9760200, ECO:0000269 PubMed:9837816}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. {ECO:0000269 PubMed:9605748, ECO:0000269 PubMed:9887330}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Relevant External Links for STK11

Genetic Association Database (GAD)
STK11
Human Genome Epidemiology (HuGE) Navigator
STK11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK11
genes like me logo Genes that share disorders with STK11: view

No data available for Genatlas for STK11 Gene

Publications for STK11 Gene

  1. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. (PMID: 18594528) Koivunen JP … Jänne PA (British journal of cancer 2008) 3 4 22 45 60
  2. LKB1 gene mutations in Japanese lung cancer patients. (PMID: 17711506) Onozato R … Mitsudomi T (Cancer science 2007) 3 4 22 45 60
  3. Prevalence and specificity of LKB1 genetic alterations in lung cancers. (PMID: 17384680) Matsumoto S … Yokota J (Oncogene 2007) 3 4 22 45 60
  4. Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas. (PMID: 20559149) Gao B … Ji H (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010) 3 4 45 60
  5. Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma. (PMID: 19229701) Strazisar M … Glavac D (Cancer investigation 2009) 3 22 45 60

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