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Aliases for STK10 Gene

Aliases for STK10 Gene

  • Serine/Threonine Kinase 10 2 3
  • Lymphocyte-Oriented Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • LOK 3 4
  • EC 2.7.11 63
  • PRO2729 3

External Ids for STK10 Gene

Previous GeneCards Identifiers for STK10 Gene

  • GC05M171705
  • GC05M172172
  • GC05M171405
  • GC05M171451
  • GC05M171403
  • GC05M166567

Summaries for STK10 Gene

Entrez Gene Summary for STK10 Gene

  • This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for STK10 Gene

STK10 (Serine/Threonine Kinase 10) is a Protein Coding gene. Diseases associated with STK10 include seminal vesicle tumor and male reproductive organ benign neoplasm. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for STK10 Gene

  • Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.

Gene Wiki entry for STK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STK10 Gene

Genomics for STK10 Gene

Regulatory Elements for STK10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STK10 Gene

Chromosome:
5
Start:
172,042,070 bp from pter
End:
172,188,386 bp from pter
Size:
146,317 bases
Orientation:
Minus strand

Genomic View for STK10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STK10 Gene

Proteins for STK10 Gene

  • Protein details for STK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94804-STK10_HUMAN
    Recommended name:
    Serine/threonine-protein kinase 10
    Protein Accession:
    O94804
    Secondary Accessions:
    • A6ND35
    • B2R8F5
    • B3KMY1
    • Q6NSK0
    • Q9UIW4

    Protein attributes for STK10 Gene

    Size:
    968 amino acids
    Molecular mass:
    112135 Da
    Quaternary structure:
    • Homodimer; homodimerization is required for activation segment autophosphorylation.
    Miscellaneous:
    • Inhibition by erlotinib, an orally administered EGFR tyrosine kinase inhibitor used for treatment, enhances STK10-dependent lymphocytic responses, possibly leading to the aggravation of skin inflammation observed upon treatment by erlotinib.
    SequenceCaution:
    • Sequence=BAG51143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STK10 Gene

neXtProt entry for STK10 Gene

Proteomics data for STK10 Gene at MOPED

Post-translational modifications for STK10 Gene

  • Autophosphorylates following homodimerization, leading to activation of the protein
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for STK10 Gene

Gene Families for STK10 Gene

Suggested Antigen Peptide Sequences for STK10 Gene

Graphical View of Domain Structure for InterPro Entry

O94804

UniProtKB/Swiss-Prot:

STK10_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with STK10: view

Function for STK10 Gene

Molecular function for STK10 Gene

GENATLAS Biochemistry:
serine/threonine kinase 10
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.

Enzyme Numbers (IUBMB) for STK10 Gene

Gene Ontology (GO) - Molecular Function for STK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 18239682
GO:0005515 protein binding IPI 12639966
GO:0005524 ATP binding IEA --
GO:0042801 polo kinase kinase activity TAS 12639966
genes like me logo Genes that share ontologies with STK10: view
genes like me logo Genes that share phenotypes with STK10: view

Animal Models for STK10 Gene

MGI Knock Outs for STK10:

Animal Model Products

CRISPR Products

miRNA for STK10 Gene

miRTarBase miRNAs that target STK10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK10

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for STK10 Gene

Localization for STK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STK10 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STK10 Gene COMPARTMENTS Subcellular localization image for STK10 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for STK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA 19255442
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with STK10: view

Pathways & Interactions for STK10 Gene

SuperPathways for STK10 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with STK10: view

Pathways by source for STK10 Gene

1 Qiagen pathway for STK10 Gene

Interacting Proteins for STK10 Gene

SIGNOR curated interactions for STK10 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for STK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9278426
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0023014 signal transduction by protein phosphorylation TAS 12639966
GO:0031098 stress-activated protein kinase signaling cascade IBA --
genes like me logo Genes that share ontologies with STK10: view

Drugs & Compounds for STK10 Gene

(4) Drugs for STK10 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
serine Nutra 420
threonine Nutra 16
tyrosine Nutra 547

(1) Additional Compounds for STK10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with STK10: view

Transcripts for STK10 Gene

Unigene Clusters for STK10 Gene

Serine/threonine kinase 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STK10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - - - -
SP2:
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for STK10 Gene

GeneLoc Exon Structure for
STK10
ECgene alternative splicing isoforms for
STK10

Expression for STK10 Gene

mRNA expression in normal human tissues for STK10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STK10 Gene

This gene is overexpressed in Whole Blood (x15.2).

Protein differential expression in normal tissues from HIPED for STK10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8), Lymph node (10.5), Tlymphocyte (9.0), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STK10 Gene



SOURCE GeneReport for Unigene cluster for STK10 Gene Hs.744005

mRNA Expression by UniProt/SwissProt for STK10 Gene

O94804-STK10_HUMAN
Tissue specificity: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
genes like me logo Genes that share expression patterns with STK10: view

Protein tissue co-expression partners for STK10 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for STK10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STK10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STK10 35
  • 89.44 (n)
  • 90.37 (a)
STK10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STK10 35
  • 89.45 (n)
  • 91.62 (a)
STK10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk10 35
  • 86.09 (n)
  • 88.72 (a)
Stk10 16
Stk10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STK10 35
  • 99.36 (n)
  • 99.28 (a)
STK10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stk10 35
  • 84.02 (n)
  • 85.82 (a)
oppossum
(Monodelphis domestica)
Mammalia STK10 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STK10 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves STK10 35
  • 73.83 (n)
  • 73.91 (a)
STK10 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STK10 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk10 35
  • 67.91 (n)
  • 69 (a)
Str.20235 35
African clawed frog
(Xenopus laevis)
Amphibia stk10-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii stk10 35
  • 66.7 (n)
  • 64.08 (a)
zgc63495 35
stk10 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4527 37
  • 37 (a)
slik 35
  • 58.25 (n)
  • 49.93 (a)
slik 36
  • 23 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010551 35
  • 35.22 (n)
  • 17.69 (a)
worm
(Caenorhabditis elegans)
Secernentea C04A11.3 37
  • 40 (a)
gck-4 35
  • 49.29 (n)
  • 39.86 (a)
gck-4 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8272 36
  • 34 (a)
OneToMany
Species with no ortholog for STK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STK10 Gene

ENSEMBL:
Gene Tree for STK10 (if available)
TreeFam:
Gene Tree for STK10 (if available)

Paralogs for STK10 Gene

Paralogs for STK10 Gene

(6) SIMAP similar genes for STK10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STK10: view

Variants for STK10 Gene

Sequence variations from dbSNP and Humsavar for STK10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_023827 Testicular germ cell tumor (TGCT)
VAR_041131 -
VAR_041132 -
VAR_041133 -
VAR_041134 -

Structural Variations from Database of Genomic Variants (DGV) for STK10 Gene

Variant ID Type Subtype PubMed ID
nsv462523 CNV Loss 19166990
esv2677017 CNV Deletion 23128226
esv2141451 CNV Deletion 18987734
esv2731089 CNV Deletion 23290073
esv2674681 CNV Deletion 23128226
nsv10770 CNV Loss 18304495
dgv1872e1 CNV Complex 17122850
nsv10771 CNV Loss 18304495
esv2673910 CNV Deletion 23128226

Variation tolerance for STK10 Gene

Residual Variation Intolerance Score: 50.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STK10 Gene

HapMap Linkage Disequilibrium report
STK10
Human Gene Mutation Database (HGMD)
STK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STK10 Gene

Disorders for STK10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for STK10 Gene - From: Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
seminal vesicle tumor
  • tumor of seminal vesicle
male reproductive organ benign neoplasm
testicular germ cell tumor
  • male germ cell tumor, somatic
anus disease
  • nontraumatic tear of anus
cholecystolithiasis
- elite association
Search STK10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STK10_HUMAN
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. {ECO:0000269 PubMed:16175573}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for STK10

Genetic Association Database (GAD)
STK10
Human Genome Epidemiology (HuGE) Navigator
STK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STK10
genes like me logo Genes that share disorders with STK10: view

No data available for Genatlas for STK10 Gene

Publications for STK10 Gene

  1. Molecular cloning of the human gene STK10 encoding lymphocyte- oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. (PMID: 10199912) Kuramochi S. … Karasuyama H. (Immunogenetics 1999) 2 23 67
  2. Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR. (PMID: 19945867) Takayama T. … Sato M. (Bioorg. Med. Chem. Lett. 2010) 23 67
  3. Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR. (PMID: 19945869) Takayama T. … Sato M. (Bioorg. Med. Chem. Lett. 2010) 23 67
  4. T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers. (PMID: 19272155) Rody A. … Kaufmann M. (Breast Cancer Res. 2009) 23 67
  5. Affinity classification of kinase inhibitors by mass spectrometric methods and validation using standard IC(50) measurements. (PMID: 19067573) Jecklin M.C. … Zenobi R. (Anal. Chem. 2009) 23 67

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