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STK10 Gene

protein-coding   GIFtS: 61
GCID: GC05M171403

Serine/Threonine Kinase 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Threonine Kinase 101 2     PRO27292
LOK2 3 5     Serine/Threonine-Protein Kinase 102
Lymphocyte-Oriented Kinase2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 113881   Entrez Gene: 67932   Ensembl: ENSG000000727867   OMIM: 6039195   UniProtKB: O948043   

Export aliases for STK10 gene to outside databases

Previous GC identifers: GC05M171705 GC05M172172 GC05M171405 GC05M171451 GC05M166567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STK10 Gene:
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several
known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and
overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase
can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase
1 pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for STK10 Gene:
STK10 (serine/threonine kinase 10) is a protein-coding gene. Diseases associated with STK10 include cholecystolithiasis, and testicular germ cell tumor. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and
possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such
as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo
kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo

Gene Wiki entry for STK10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the STK10 gene promoter:
         ER-alpha   AML1a   AP-1   ATF-2   c-Jun   NF-kappaB   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTK10 promoter sequence
   Search Chromatin IP Primers for STK10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

STK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M171403:  view genomic region     (about GC identifiers)

Start:
171,469,074 bp from pter      End:
171,615,390 bp from pter
Size:
146,317 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STK10_HUMAN, O94804 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 10  
Size: 968 amino acids; 112135 Da
Subunit: Homodimer; homodimerization is required for activation segment autophosphorylation
Miscellaneous: Inhibition by erlotinib, an orally administered EGFR tyrosine kinase inhibitor used for treatment,
enhances STK10-dependent lymphocytic responses, possibly leading to the aggravation of skin inflammation observed
upon treatment by erlotinib (PubMed:21606217)
Sequence caution: Sequence=BAG51143.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
4 PDB 3D structures from and Proteopedia for STK10:
2J7T (3D)        4AOT (3D)        4BC6 (3D)        4EQU (3D)    
Secondary accessions: A6ND35 B2R8F5 B3KMY1 Q6NSK0 Q9UIW4

Explore the universe of human proteins at neXtProt for STK10: NX_O94804

Explore proteomics data for STK10 at MOPED

Post-translational modifications: 

  • Autophosphorylates following homodimerization, leading to activation of the protein1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for STK10 (O94804) (see all 13)
     QLQNEKC  KLRPRKK  IIHRDLKA  KQQLKDQYF 


    See STK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005981.3  
    ENSEMBL proteins: 
     ENSP00000176763   ENSP00000428806  

    STK10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine kinase 10
    SLK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR022165 PKK

    Graphical View of Domain Structure for InterPro Entry O94804

    ProtoNet protein and cluster: O94804

    UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    STK10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STK10_HUMAN, O94804
    Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and
    possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such
    as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo
    kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the
    ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain.
    Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib

         Genatlas biochemistry entry for STK10:
    serine/threonine kinase 10

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA18239682
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12639966
         
    STK10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for STK10:
     Decreased POU5F1-GFP protein e  Decreased mitotic index  Increased colony dispersion (i 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stk10):
     hematopoietic system  immune system 

    STK10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stk10tm1Hkar for STK10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STK10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STK10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STK10

    miRNA
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    miRTarBase miRNAs that target STK10:
    hsa-mir-484 (MIRT042193)

    Block miRNA regulation of human, mouse, rat STK10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK10 (see all 24):
    hsa-miR-142-5p hsa-miR-3194-5p hsa-miR-181c hsa-miR-520d-5p hsa-miR-4251 hsa-miR-513a-5p hsa-miR-141* hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidSTK10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STK10
    Predesigned siRNA for gene silencing in human, mouse, rat STK10

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: STK10 (NM_005990)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STK10_HUMAN, O94804: Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IDA19255442
    GO:0070062extracellular vesicular exosome IDA--

    STK10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STK10 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37
    2Selected targets of ESR1
    Selected targets of ESR1

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STK10
        Sperm Motility



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STK10
    Interactions:

        Search GeneGlobe Interaction Network for STK10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for STK10 (O948041 ENSP000001767634) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK10O948041EBI-3951541,EBI-3951541
    BRAFENSP000002886024STRING: ENSP00000288602
    ARAFENSP000003662444STRING: ENSP00000366244
    RAF1ENSP000002518494STRING: ENSP00000251849
    EPS8ENSP000002811724STRING: ENSP00000281172
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9278426
    GO:0007049cell cycle IEA--
    GO:0023014signal transduction by phosphorylation TAS12639966
    GO:0046777protein autophosphorylation IDA12639966
    GO:0071593lymphocyte aggregation IEA--

    STK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STK10

    2 HMDB Compounds for STK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 Novoseek inferred chemical compound relationships for STK10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.2 9 19290923 (1), 18321037 (1), 17600705 (1), 18278858 (1)
    threonine 23.5 2 11903060 (1), 10199912 (1)
    serine 8.26 2 11903060 (1), 10199912 (1)



    STK10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STK10 gene: 
    NM_005990.3  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000176763(uc003mbo.1) ENST00000517360 ENST00000520476 ENST00000523615
    ENST00000519269 ENST00000523603 ENST00000522879 ENST00000517775 ENST00000517524
    ENST00000517527 ENST00000522936 ENST00000519710 ENST00000521322 ENST00000518267
    ENST00000519441 ENST00000517381
    miRNA
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    Block miRNA regulation of human, mouse, rat STK10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STK10 (see all 24):
    hsa-miR-142-5p hsa-miR-3194-5p hsa-miR-181c hsa-miR-520d-5p hsa-miR-4251 hsa-miR-513a-5p hsa-miR-141* hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidSTK10 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STK10 (NM_005990)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STK10
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STK10
      QuantiTect SYBR Green Assays in human, mouse, rat STK10
      QuantiFast Probe-based Assays in human, mouse, rat STK10

    Selected AceView cDNA sequences (see all 249):

    BQ021235 CA305895 BM054894 BM671961 BQ053164 BE743337 AW137897 CD369094 
    AW608257 AW204633 BX113899 AA379036 BI818657 CD366166 BE504180 AA353709 
    CR607624 BF725353 AW005332 BM703634 BM561157 BM561960 BE733507 BM559736 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STK10 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                          -     -     -     -           -     -                                                                             -     -     -   
    SP2:                                                                                                                                                            
    SP3:                                                        -     -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                -     -     -                                                                                                               

    ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
    SP1:  -                       -                       -           -               
    SP2:                          -                       -                           
    SP3:                                                                              
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for STK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAAGCAC
    STK10 Expression
    About this image


    STK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    STK10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STK10 Protein Expression

    UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
    Tissue specificity: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood
    leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and
    lung

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    QuantiFast Probe-based Assays in human, mouse, rat STK10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STK10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk101 , 5 serine/threonine kinase 101, 5 86.09(n)1
    88.72(a)1
      11 (18.97 cM)5
    208681  NM_009288.21  NP_033314.21 
     325333055 
    chicken
    (Gallus gallus)
    Aves STK101 serine/threonine kinase 10 73.83(n)
    73.91(a)
      416204  XM_414529.4  XP_414529.4 
    lizard
    (Anolis carolinensis)
    Reptilia STK106
    serine/threonine kinase 10
    69(a)
    1 ↔ 1
    2(123755758-123805328)
    African clawed frog
    (Xenopus laevis)
    Amphibia stk10-A-prov2 serine/threonine kinase 10 (polo-like kinase kinase more 76.55(n)    AF100165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc634952 similar to serine/threonine kinase 10 77.13(n)   394108  BC055124.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45273
    slik1
    protein amino acid phosphorylation
    receptor signaling more3
    Sterile20-like kinase1
    37(a)3
    58.25(n)1
    49.93(a)1
      378931  NM_001014549.31  NP_001014549.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C04A11.33
    gck-41
    serine/threonine kinase3
    gck-41
    40(a)3
    49.29(n)1
    39.86(a)1
      X(13712484-13717302)3
    1814881  NM_077889.11  NP_510290.11 


    ENSEMBL Gene Tree for STK10 (if available)
    TreeFam Gene Tree for STK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STK10 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  TAOK12  MINK12  SLK2  
    6 SIMAP similar genes for STK10 using alignment to 2 protein entries:     STK10_HUMAN (see all proteins):
    MST4    SLK    MAP2K6    STK4    CDK4    NEK7

    STK10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STK10 (see all 3702)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0238274
    Testicular germ cell tumor (TGCT)4--see VAR_0238272 K E mis40--------
    rs623845901,2
    C,F--171468590(+) CGCCTG/ATCTCC 1 -- ds50016Minor allele frequency- A:0.12WA NA EA 364
    rs733142461,2
    C,F--171468622(+) TGGCTC/GATGCC 1 -- ds50012Minor allele frequency- G:0.07WA 120
    rs1496573001,2
    C--171468643(+) GCTACC/TCAGGA 1 -- ds50010--------
    rs1167620481,2
    C,F--171468833(+) TGAAAA/GCTTTT 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs733142491,2
    C,F--171468967(+) GCTGCC/TGTATG 1 -- ds50012Minor allele frequency- T:0.07WA 120
    rs1897281051,2
    --171469052(+) TCCACC/TCCAAT 1 -- ds50010--------
    rs1814630471,2
    --171469071(+) ACAACC/GTGAAC 1 -- ds50010--------
    rs1454717131,2
    --171469113(+) TATTTA/GCATTC 1 -- ut310--------
    rs1860382771,2
    --171469141(+) GAGAAA/CATTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STK10 (171469074 - 171615390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for STK10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731089CNV Deletion23290073
    esv2141451CNV Deletion18987734
    esv2677017CNV Deletion23128226
    esv2674681CNV Deletion23128226
    esv2673910CNV Deletion23128226
    nsv10770CNV Loss18304495
    nsv462523CNV Loss19166990
    nsv10771CNV Loss18304495
    dgv1872e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): STK10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STK10
    DNA2.0 Custom Variant and Variant Library Synthesis for STK10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603919    OMIM disorders: --

    UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all
    testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell
    neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal
    carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. Note=The disease may be caused by mutations affecting
    the gene represented in this entry

  • 10 diseases for STK10:    
    About MalaCards
    cholecystolithiasis    testicular germ cell tumor    anus disease    germ cell tumors
    collecting duct carcinoma    appendicitis    asthma    multiple myeloma
    myeloma    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for STK10:
    Cholecystolithiasis     Appendicitis

    STK10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STK10
    Human Genome Epidemiology (HuGE) Navigator: STK10 (2 documents)

    Export disorders for STK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STK10 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with STK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human gene STK10 encoding lymphocyte- oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. (PubMed id 10199912)1, 2, 3, 9 Kuramochi S....Karasuyama H. (Immunogenetics 1999)
    2. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. (PubMed id 11903060)1, 2, 9 Tao L....August A. (Biochem. J. 2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. (PubMed id 19255442)1, 2 Belkina N.V.... Shaw S. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. (PubMed id 18239682)1, 2 Pike A.C.... Knapp S. (EMBO J. 2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. (PubMed id 16175573)1, 2 Bignell G.... Stratton M.R. (Genes Chromosomes Cancer 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. (PubMed id 12639966)1, 2 Walter S.A.... Hill R.J. (J. Biol. Chem. 2003)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6793 HGNC: 11388 AceView: STK10 Ensembl:ENSG00000072786 euGenes: HUgn6793
    ECgene: STK10 H-InvDB: STK10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STK10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STK10 gene:
    Search GeneIP for patents involving STK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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