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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STK10 Gene

protein-coding   GIFtS: 61
GCID: GC05M171403

serine/threonine kinase 10
 Explore 12 diseases affiliated with
STK10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STK10    

Aliases
for STK10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine/Threonine Kinase 101 2     EC 2.7.11.13 8
LOK1 2 3 5     Serine/Threonine-Protein Kinase 102
PRO27291 2     EC 2.7.118
Lymphocyte-Oriented Kinase2 3     

External Ids:    HGNC: 113881   Entrez Gene: 67932   Ensembl: ENSG000000727867   OMIM: 6039195   UniProtKB: O948043   

Export aliases for STK10 gene to outside databases

Previous GC identifers: GC05M171705 GC05M172172 GC05M171405 GC05M171451 GC05M166567


Summaries
for STK10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STK10:
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known
polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a
kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively
regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and
possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as
MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase
kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo

Gene Wiki entry for STK10


Genomic Views
for STK10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STK10 gene promoter:
         ER-alpha   AML1a   AP-1   ATF-2   c-Jun   NF-kappaB   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STK10 promoter sequence
   Search SABiosciences Chromatin IP Primers for STK10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

STK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STK10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M171403:  view genomic region     (about GC identifiers)

Start:
 171,469,074 bp from pter      End:
 171,615,390 bp from pter
Size:
 146,317 bases      Orientation:
 minus strand

Proteins
for STK10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STK10_HUMAN, O94804 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase 10  
Size: 968 amino acids; 112135 Da
Subunit: Homodimer; homodimerization is required for activation segment autophosphorylation
Subcellular location: Cell membrane; Peripheral membrane protein
Miscellaneous: Inhibition by erlotinib, an orally administered EGFR tyrosine kinase inhibitor used for treatment,
enhances STK10-dependent lymphocytic responses, possibly leading to the aggravation of skin inflammation observed upon
treatment by erlotinib (PubMed:21606217)
Sequence caution: Sequence=BAG51143.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
4 PDB 3D structures from and Proteopedia for STK10:
2J7T (3D)        4AOT (3D)        4BC6 (3D)        4EQU (3D)    
Secondary accessions: A6ND35 B2R8F5 B3KMY1 Q6NSK0 Q9UIW4

Explore the universe of human proteins at neXtProt for STK10: NX_O94804

Post-translational modifications:

  • Autophosphorylates following homodimerization, leading to activation of the protein1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94804

    • 4/13 DME Specific Peptides for STK10 (O94804) (see all 13)
     QLQNEKC  KLRPRKK  IIHRDLKA  KQQLKDQYF 

    STK10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005981.3  
    ENSEMBL proteins: 
     ENSP00000176763   ENSP00000428806   ENSP00000442209  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant STK10 Protein
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    Novus Biologicals STK10 Proteins
    Novus Biologicals STK10 Lysate
    Sino Biological Recombinant Protein for STK10
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STK10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA19255442


    STK10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for STK10

    Protein Domains /
    Families
    for STK10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STK10 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR022165 PKK

    Graphical View of Domain Structure for InterPro Entry O94804

    ProtoNet protein and cluster: O94804

    UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for STK10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
    Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and
    possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as
    MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase
    kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding
    Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically
    inhibited by erlotinib. Slightly inhibited by gefitinib

         Genatlas biochemistry entry for STK10:
    serine/threonine kinase 10

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK10
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate STK10 (see all 24):
    hsa-miR-142-5p hsa-miR-3194-5p hsa-miR-181c hsa-miR-520d-5p hsa-miR-4251 hsa-miR-513a-5p hsa-miR-141* hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmid: STK10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK10 (see all 4)
    OriGene shRNA RFP: STK10
    OriGene siRNA: STK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STK10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK10 (see all 2)
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA19255442
    GO:0005515protein binding IPI12639966
    GO:0005524ATP binding IEA--
    GO:0042801polo kinase kinase activity TAS12639966
    GO:0042803protein homodimerization activity IDA18239682


    STK10 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for STK10:
     Decreased POU5F1-GFP protein e  Decreased mitotic index  Increased colony dispersion (i 

    Animal Models:
         Mouse knock-out Stk10tm1Hkar for STK10
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Stk10):
     immune system 

    STK10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STK10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of ESR1
    		Selected targets of ESR11.00
    2Sweet Taste Signaling
    		Sperm Motility0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for STK10
        Selected targets of ESR1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STK10
        Sperm Motility



    STK10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STK10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for STK10 (ENSP000001767634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9278426
    GO:0007049cell cycle IEA--
    GO:0046777protein autophosphorylation IDA12639966
    GO:0071593lymphocyte aggregation ISS10692593
    GO:2000401regulation of lymphocyte migration IMP19255442


    STK10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STK10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STK10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STK10

    2 HMDB Compounds for STK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    3 Novoseek chemical compound relationships for STK10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.2 9 19290923 (1), 18321037 (1), 17600705 (1), 18278858 (1)
    threonine 23.5 2 11903060 (1), 10199912 (1)
    serine 8.26 2 11903060 (1), 10199912 (1)

    Search CenterWatch for drugs/clinical trials and news about STK10 

    Transcripts
    for STK10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STK10 gene: 
    NM_005990.3  

    Unigene Cluster for STK10:

    Serine/threonine kinase 10
    Hs.744005  [show with all ESTs]
    Unigene Representative Sequence: NM_005990
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000176763(uc003mbo.1) ENST00000517360 ENST00000520476 ENST00000523615
    ENST00000519269 ENST00000523603 ENST00000522879 ENST00000517775 ENST00000517524
    ENST00000517527 ENST00000522936 ENST00000519710 ENST00000521322 ENST00000518267
    ENST00000519441 ENST00000517381 ENST00000545839

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STK10
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STK10
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate STK10 (see all 24):
    hsa-miR-142-5p hsa-miR-3194-5p hsa-miR-181c hsa-miR-520d-5p hsa-miR-4251 hsa-miR-513a-5p hsa-miR-141* hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmid: STK10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STK10 (see all 4)
    OriGene shRNA RFP: STK10
    OriGene siRNA: STK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STK10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STK10 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STK10 (NM_005990)
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    Primer
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    Additional cDNA sequence: 

    AB015718.1 AF119894.1 AK022960.1 AK092814.1 AK307943.1 AK313350.1 BC014413.1 BC070077.1 

    12 DOTS entries:

    DT.415914  DT.410623  DT.425249  DT.97835282  DT.40192393  DT.95280529  DT.97796417  DT.120829952 
    DT.120829960  DT.86846388  DT.92430767  DT.91937414 

    24/249 AceView cDNA sequences (see all 249):

    AA397984 BI861805 AI174989 BQ057483 AF119894 BM069672 BG232052 BF056416 
    AA286821 AI361260 CN482063 BQ018785 CA444567 CB529387 AA287776 CB131262 
    BQ335657 BM808699 AA731245 AL133081 AI360757 BU169093 AI474049 BM561426 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for STK10 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                          -     -     -     -           -     -                                                                             -     -     -   
    SP2:                                                                                                                                                            
    SP3:                                                        -     -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                -     -     -                                                                                                               

    ExUns: 17b · 17c · 17d ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
    SP1:  -                       -                       -           -               
    SP2:                          -                       -                           
    SP3:                                                                              
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for STK10

    Expression
    for STK10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGAAGCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STK10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    KidneyMetanephrosKidney
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STK10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STK10

    SOURCE GeneReport for Unigene cluster: Hs.744005

    UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
    Tissue specificity: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood
    leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung

        SABiosciences Custom PCR Arrays for STK10
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    In Situ
    Assay Products:     
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    Orthologs
    for STK10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for STK10 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stk101 , 5 serine/threonine kinase 101, 5 86.09(n)1
    88.72(a)1    		   11 (18.97 cM)5
    208681  NM_009288.21  NP_033314.21 
     325333055 
    chicken
    (Gallus gallus)    		 Aves STK101 serine/threonine kinase 10 74.06(n)
    74.5(a)    		   416204  XM_414529.3  XP_414529.3 
    lizard
    (Anolis carolinensis)    		 Reptilia STK106
    		 --
    		 71(a)
    		 1 ↔ 1
    		 2(123771285-123801679)
    African clawed frog
    (Xenopus laevis)    		 Amphibia stk10-A-prov2 serine/threonine kinase 10 (polo-like kinase kinase more 76.55(n)    AF100165.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc634952 similar to serine/threonine kinase 10 77.13(n)   394108  BC055124.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG45273 protein amino acid phosphorylation receptor
    signaling more    		 37(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea C04A11.33 serine/threonine kinase 40(a)   X(13712484-13717302)   --


    ENSEMBL Gene Tree for STK10 (if available)
    TreeFam Gene Tree for STK10 (if available) 

    Paralogs
    for STK10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STK10 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  TAOK12  MINK12  SLK2  
    6 SIMAP similar genes for STK10 using alignment to 2 protein entries:     STK10_HUMAN (see all proteins):
    MST4    SLK    MAP2K6    STK4    CDK4    NEK7

    STK10 for paralogs           About GeneDecksing



    Genomic Variants
    for STK10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3089 NCBI SNPs in STK10 are shown (see all 3089)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs623845901,2
    		C,F,--171468590(+) CGCCTG/ATCTCC 1 -- ds50016Minor allele frequency- A:0.12WA NA EA 364
    rs733142461,2
    		C,--171468622(+) TGGCTC/GATGCC 1 -- ds50012Minor allele frequency- G:0.07WA 120
    rs1496573001,2
    		--171468643(+) GCTACC/TCAGGA 1 -- ds50010--------
    rs1167620481,2
    		F,--171468833(+) TGAAAA/GCTTTT 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs733142491,2
    		C,--171468967(+) GCTGCC/TGTATG 1 -- ds50012Minor allele frequency- T:0.07WA 120
    rs1897281051,2
    		--171469052(+) TCCACC/TCCAAT 1 -- ds50010--------
    rs1814630471,2
    		--171469071(+) ACAACC/GTGAAC 1 -- ds50010--------
    rs1454717131,2
    		--171469113(+) TATTTA/GCATTC 1 -- ut310--------
    rs1860382771,2
    		--171469141(+) GAGAAA/CATTTT 1 -- ut310--------
    rs733142531,2
    		C,--171469201(+) TTTCAT/AAAAGG 1 -- ut312Minor allele frequency- A:0.07WA 120

    HapMap Linkage Disequilibrium report for STK10 (171469074 - 171615390 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for STK10
         2 CNVs: 3586 32758
         2 Indels: 46808 33802
    Human Gene Mutation Database (HGMD): STK10

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STK10
    DNA2.0 Custom Variant and Variant Library Synthesis for STK10

    Disorders / Diseases
    for STK10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STK10 for disorders           About GeneDecksing

    OMIM gene information: 603919    OMIM disorders: --

    UniProtKB/Swiss-Prot: STK10_HUMAN, O94804
  • Defects in STK10 may be a cause of testicular germ cell tumor (TGCT) [MIM:273300]. A common solid malignancy
    • in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms

    12 diseases for STK10:    About MalaCards
    collecting duct carcinoma    germ cell tumor    testicular germ cell tumor    male germ cell tumor
    pneumopericardium    cholecystolithiasis    testicular neoplasm    anus disease
    appendicitis    breast cancer    asthma    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for STK10:
    Cholecystolithiasis     Appendicitis
    Human Genome Epidemiology (HuGE) Navigator: STK10 (2 documents)

    Export disorders for STK10 gene to outside databases

    Publications
    for STK10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STK10 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with STK10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human gene STK10 encoding lymphocyte- oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. (PubMed id 10199912)1, 2, 3, 9 Kuramochi S....Karasuyama H. (1999)
    2. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. (PubMed id 11903060)1, 2, 9 Tao L....August A. (2002)
    3. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. (PubMed id 19255442)1, 2 Belkina N.V....Shaw S. (2009)
    4. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. (PubMed id 18239682)1, 2 Pike A.C.... Knapp S. (2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. (PubMed id 16175573)1, 2 Bignell G.... Stratton M.R. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. (PubMed id 12639966)1, 2 Walter S.A....Hill R.J. (2003)
    9. Local phosphocycling mediated by LOK/SLK restricts ezr in function to the apical aspect of epithelial cells. (PubMed id 23209304)1 Viswanatha R....Bretscher A. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for STK10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STK10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6793 HGNC: 11388 AceView: STK10 Ensembl:ENSG00000072786 euGenes: HUgn6793
    ECgene: STK10 H-InvDB: STK10

    Other Databases showing STK10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STK10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STK10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STK10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STK10 gene:
    Search GeneIP for patents involving STK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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