Aliases for STIP1 Gene
External Ids for STIP1 Gene
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
GeneCards Summary for STIP1 Gene
STIP1 (Stress-Induced Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are Protein Stability and Prion diseases. GO annotations related to this gene include protein C-terminus binding and Hsp70 protein binding. An important paralog of this gene is TTC31.
UniProtKB/Swiss-Prot for STIP1 Gene
Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)