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Aliases for STIP1 Gene

Aliases for STIP1 Gene

  • Stress-Induced Phosphoprotein 1 2 3
  • Transformation-Sensitive Protein IEF SSP 3521 3 4
  • Renal Carcinoma Antigen NY-REN-11 3 4
  • Hsp70/Hsp90-Organizing Protein 2 3
  • Hsc70/Hsp90-Organizing Protein 3 4
  • STI1 3 4
  • HOP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 94n 3
  • Stress-Induced-Phosphoprotein 1 2
  • NY-REN-11 Antigen 3
  • IEF-SSP-3521 3
  • HEL-S-94n 3
  • STI1L 3
  • P60 3

External Ids for STIP1 Gene

Previous GeneCards Identifiers for STIP1 Gene

  • GC11P066389
  • GC11M065612
  • GC11P063728
  • GC11P063729
  • GC11P063709
  • GC11P063953
  • GC11P060283

Summaries for STIP1 Gene

Entrez Gene Summary for STIP1 Gene

  • STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

GeneCards Summary for STIP1 Gene

STIP1 (Stress-Induced Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are Neuroscience and Prion diseases. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is TTC31.

UniProtKB/Swiss-Prot for STIP1 Gene

  • Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)

Gene Wiki entry for STIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STIP1 Gene

Genomics for STIP1 Gene

Regulatory Elements for STIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STIP1 Gene

Chromosome:
11
Start:
64,185,272 bp from pter
End:
64,204,548 bp from pter
Size:
19,277 bases
Orientation:
Plus strand

Genomic View for STIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STIP1 Gene

Proteins for STIP1 Gene

  • Protein details for STIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31948-STIP1_HUMAN
    Recommended name:
    Stress-induced-phosphoprotein 1
    Protein Accession:
    P31948
    Secondary Accessions:
    • B4DM70
    • F5H0T1
    • G3XAD8
    • Q3ZCU9
    • Q5TZU9

    Protein attributes for STIP1 Gene

    Size:
    543 amino acids
    Molecular mass:
    62639 Da
    Quaternary structure:
    • Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG. Interacts with METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction.

    Three dimensional structures from OCA and Proteopedia for STIP1 Gene

    Alternative splice isoforms for STIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STIP1 Gene

Proteomics data for STIP1 Gene at MOPED

Post-translational modifications for STIP1 Gene

  • Ubiquitination at Lys 10, Lys 13, Lys 32, Lys 68, Lys 109, Lys 123, Lys 284, Lys 325, Lys 434, Lys 442, Lys 446, Lys 462, and Lys 513
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STIP1 (STI1)

No data available for DME Specific Peptides for STIP1 Gene

Domains & Families for STIP1 Gene

Gene Families for STIP1 Gene

Suggested Antigen Peptide Sequences for STIP1 Gene

Graphical View of Domain Structure for InterPro Entry

P31948

UniProtKB/Swiss-Prot:

STIP1_HUMAN :
  • The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90
  • Contains 9 TPR repeats.
Domain:
  • The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90
  • Contains 2 STI1 domains.
Similarity:
  • Contains 9 TPR repeats.
genes like me logo Genes that share domains with STIP1: view

Function for STIP1 Gene

Molecular function for STIP1 Gene

GENATLAS Biochemistry:
stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles in normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts
UniProtKB/Swiss-Prot Function:
Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)

Gene Ontology (GO) - Molecular Function for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20029029
GO:0008022 protein C-terminus binding IEA --
GO:0030544 Hsp70 protein binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with STIP1: view
genes like me logo Genes that share phenotypes with STIP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for STIP1 Gene

Localization for STIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STIP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STIP1 Gene COMPARTMENTS Subcellular localization image for STIP1 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 2
plasma membrane 2
chloroplast 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005794 Golgi apparatus TAS 1569099
GO:0043209 myelin sheath IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with STIP1: view

Pathways & Interactions for STIP1 Gene

SuperPathways for STIP1 Gene

genes like me logo Genes that share pathways with STIP1: view

Pathways by source for STIP1 Gene

1 Qiagen pathway for STIP1 Gene
1 Cell Signaling Technology pathway for STIP1 Gene
1 KEGG pathway for STIP1 Gene

Gene Ontology (GO) - Biological Process for STIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 1569099
genes like me logo Genes that share ontologies with STIP1: view

No data available for SIGNOR curated interactions for STIP1 Gene

Drugs & Compounds for STIP1 Gene

(2) Drugs for STIP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
ATP Pharma Activator 0

(1) Additional Compounds for STIP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Steroid
genes like me logo Genes that share compounds with STIP1: view

Transcripts for STIP1 Gene

Unigene Clusters for STIP1 Gene

Stress-induced-phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STIP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STIP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ·
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4: - - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8: -
SP9:

ExUns: 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for STIP1 Gene

GeneLoc Exon Structure for
STIP1
ECgene alternative splicing isoforms for
STIP1

Expression for STIP1 Gene

mRNA expression in normal human tissues for STIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STIP1 Gene



SOURCE GeneReport for Unigene cluster for STIP1 Gene Hs.337295

genes like me logo Genes that share expression patterns with STIP1: view

Protein tissue co-expression partners for STIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STIP1 Gene

Orthologs for STIP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STIP1 35
  • 89.81 (n)
  • 97.05 (a)
-- 36
  • 57 (a)
OneToMany
STIP1 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STIP1 35
  • 90.48 (n)
  • 96.7 (a)
STIP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stip1 35
  • 87.85 (n)
  • 96.87 (a)
Stip1 16
Stip1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STIP1 35
  • 99.83 (n)
  • 100 (a)
STIP1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stip1 35
  • 88.4 (n)
  • 97.05 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC101748085 35
  • 71.19 (n)
  • 76.61 (a)
STIP1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STIP1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76181 35
stip1 35
  • 75.57 (n)
  • 88.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia stip1-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29081 35
stip1 35
  • 73.41 (n)
  • 79.59 (a)
stip1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hop 37
  • 44 (a)
Hop 35
  • 60.54 (n)
  • 56.37 (a)
Hop 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010188 35
  • 61.58 (n)
  • 60.44 (a)
worm
(Caenorhabditis elegans)
Secernentea R09E12.3 37
  • 56 (a)
sti-1 35
  • 59.28 (n)
  • 56.96 (a)
sti-1 36
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL224W 35
  • 51.18 (n)
  • 41.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07062g 35
  • 49.57 (n)
  • 39.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 35
  • 49.88 (n)
  • 41.79 (a)
STI1 36
  • 37 (a)
OneToMany
STI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12270 35
  • 52.2 (n)
  • 47.3 (a)
soybean
(Glycine max)
eudicotyledons Gma.8435 35
rice
(Oryza sativa)
Liliopsida Os.13461 35
Os02g0644100 35
  • 53.02 (n)
  • 47.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8679 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.271 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00714 35
  • 51.61 (n)
  • 42.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sti1 35
  • 50 (n)
  • 44.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2588 36
  • 52 (a)
OneToOne
Species with no ortholog for STIP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for STIP1 Gene

ENSEMBL:
Gene Tree for STIP1 (if available)
TreeFam:
Gene Tree for STIP1 (if available)

Paralogs for STIP1 Gene

Paralogs for STIP1 Gene

(3) SIMAP similar genes for STIP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for STIP1 Gene

genes like me logo Genes that share paralogs with STIP1: view

Variants for STIP1 Gene

Sequence variations from dbSNP and Humsavar for STIP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14788 -- 64,204,408(+) AGTTG(G/T)TTTTT utr-variant-3-prime
rs1049690 -- 64,204,333(+) GGTCT(C/T)TTCAC utr-variant-3-prime
rs2070232 -- 64,203,153(+) GCTGC(A/G)CTGGA synonymous-codon, reference
rs2236647 -- 64,197,133(+) GCTGA(C/T)TGATG intron-variant
rs2236648 -- 64,197,185(+) AGTTG(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STIP1 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
dgv15n68 CNV Loss 17160897
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
nsv897663 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv825943 CNV Gain 20364138

Variation tolerance for STIP1 Gene

Residual Variation Intolerance Score: 7.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STIP1 Gene

HapMap Linkage Disequilibrium report
STIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIP1 Gene

Disorders for STIP1 Gene

Relevant External Links for STIP1

Genetic Association Database (GAD)
STIP1
Human Genome Epidemiology (HuGE) Navigator
STIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STIP1
genes like me logo Genes that share disorders with STIP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STIP1 Gene

Publications for STIP1 Gene

  1. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress- inducible yeast protein STI1. (PMID: 1569099) Honore B. … Celis J.E. (J. Biol. Chem. 1992) 2 23 67
  2. Hsp90 cochaperone Aha1 is a negative regulator of the Saccharomyces MAL activator and acts early in the chaperone activation pathway. (PMID: 20177068) Ran F. … Michels C.A. (J. Biol. Chem. 2010) 23 67
  3. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PMID: 19254810) Hawkins G.A. … Bleecker E.R. (J. Allergy Clin. Immunol. 2009) 23 67
  4. The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization. (PMID: 19356137) Longshaw V.M. … Blatch G.L. (Protein Pept. Lett. 2009) 23 67
  5. Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. (PMID: 19586912) Kajander T. … Regan L. (J. Biol. Chem. 2009) 23 67

Products for STIP1 Gene

Sources for STIP1 Gene

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