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STIP1 Gene

protein-coding   GIFtS: 68
GCID: GC11P063953

Stress-Induced Phosphoprotein 1

(Previous name: stress-induced-phosphoprotein 1)
  Search for STIP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stress-Induced Phosphoprotein 11 2     HEL-S-94n2
Stress-Induced-Phosphoprotein 11 2     IEF-SSP-35212
Hsp70/Hsp90-Organizing Protein1 2     P602
Hsc70/Hsp90-Organizing Protein2 3     STI1L2
Renal Carcinoma Antigen NY-REN-112 3     Epididymis Secretory Sperm Binding Protein Li 94n2
Transformation-Sensitive Protein IEF SSP 35212 3     NY-REN-11 Antigen2
STI12 3     Hop3
HOP2 5     

External Ids:    HGNC: 113871   Entrez Gene: 109632   Ensembl: ENSG000001684397   OMIM: 6050635   UniProtKB: P319483   

Export aliases for STIP1 gene to outside databases

Previous GC identifers: GC11P066389 GC11M065612 GC11P064203 GC11P063728 GC11P063729 GC11P063709 GC11P060283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STIP1 Gene:
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see
HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90
by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits
the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these
chaperones (Song and Masison, 2005 (PubMed 16100115)).(supplied by OMIM, Jul 2009)

GeneCards Summary for STIP1 Gene:
STIP1 (stress-induced phosphoprotein 1) is a protein-coding gene. GO annotations related to this gene include Hsp70 protein binding and protein C-terminus binding. An important paralog of this gene is TTC31.

UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948
Function: Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)

Gene Wiki entry for STIP1 (Hop) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STIP1 gene promoter:
         Sp1   Bach2   CUTL1   NF-kappaB   AREB6   Egr-2   POU2F1   USF-1   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTIP1 promoter sequence
   Search Chromatin IP Primers for STIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

STIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STIP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063953:  view genomic region     (about GC identifiers)

Start:
63,952,744 bp from pter      End:
63,972,020 bp from pter
Size:
19,277 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948 (See protein sequence)
Recommended Name: Stress-induced-phosphoprotein 1  
Size: 543 amino acids; 62639 Da
Subunit: Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG. Interacts with
METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction
5 PDB 3D structures from and Proteopedia for STIP1:
1ELR (3D)        1ELW (3D)        2LNI (3D)        3ESK (3D)        3FWV (3D)    
Secondary accessions: Q5TZU9

Explore the universe of human proteins at neXtProt for STIP1: NX_P31948

Explore proteomics data for STIP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys32, Lys68, Lys100, Lys109, Lys123, Lys246, Lys284, Lys325, Lys434,
                                 Lys442, Lys446, Lys462, Lys513
  • Modification sites at PhosphoSitePlus

  • See STIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269581.1  NP_001269582.1  NP_006810.1  

    ENSEMBL proteins: 
     ENSP00000351646   ENSP00000305958   ENSP00000441036   ENSP00000445957   ENSP00000442704  
     ENSP00000443416  

    STIP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for STIP1

     
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    STIP1 Antibody Products:

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    STIP1 Assay Products:

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    Search eBioscience for ELISAs for STIP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR006636 STI1_HS-bd
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P31948

    ProtoNet protein and cluster: P31948

    2 Blocks protein domains:
    IPB006636 Heat shock chaperonin-binding
    IPB011595 TPR-related region


    UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948
    Domain: The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A
    domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90
    Similarity: Contains 2 STI1 domains
    Similarity: Contains 9 TPR repeats


    Find genes that share domains with STIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STIP1_HUMAN, P31948
    Function: Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)

         Genatlas biochemistry entry for STIP1:
    stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles
    in normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008022protein C-terminus binding ----
    GO:0030544Hsp70 protein binding ----
    GO:0044822poly(A) RNA binding IDA--
    GO:0051087chaperone binding ----
         
    Find genes that share ontologies with STIP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STIP1:
     Increased HPV18 LCR reporter a 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stip1):
     cellular  embryogenesis  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  nervous system 

    Find genes that share phenotypes with STIP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STIP1
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    miRNA
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    miRTarBase miRNAs that target STIP1:
    hsa-mir-193a-3p (MIRT044894), hsa-let-7b-5p (MIRT051957), hsa-mir-183-5p (MIRT047040), hsa-mir-1180-3p (MIRT035915), hsa-mir-16-5p (MIRT032016), hsa-mir-484 (MIRT041679)

    Block miRNA regulation of human, mouse, rat STIP1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate STIP1:
    hsa-miR-892b hsa-miR-324-3p hsa-miR-591 hsa-miR-3202 hsa-miR-2278 hsa-miR-3616-3p hsa-miR-4267 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSTIP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STIP1

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STIP1_HUMAN, P31948: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol2
    chloroplast1
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005794Golgi apparatus TAS1569099
    GO:0043234protein complex ----

    Find genes that share ontologies with STIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability
    2Prion diseases
    Prion diseases


    Find genes that share SuperPaths with STIP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STIP1
        HOP Signaling

    1 Cell Signaling Technology (CST) Pathway for STIP1
        Protein Stability



    1 Kegg Pathway  (Kegg details for STIP1):
        Prion diseases

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STIP1
    Interactions:

        GeneGlobe Interaction Network for STIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STIP1 (P319481, 2, 3 ENSP000003059584) via UniProtKB, MINT, STRING, and/or I2D (see all 301)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=3 
    ENSG00000215328P081073I2D: score=3 
    ENSG00000224501P081073I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress TAS1569099

    Find genes that share ontologies with STIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STIP1

    3 Novoseek inferred chemical compound relationships for STIP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 44.2 8 9148915 (3), 15632128 (3), 8939864 (1), 8952474 (1)
    progesterone 29.6 2 8423808 (1), 8776728 (1)
    atp 20.1 2 9774640 (1), 18485364 (1)



    Find genes that share compounds with STIP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STIP1 gene (3 alternative transcripts): 
    NM_001282652.1  NM_001282653.1  NM_006819.2  

    Unigene Cluster for STIP1:

    Stress-induced-phosphoprotein 1
    Hs.337295  [show with all ESTs]
    Unigene Representative Sequence: BC039299
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358794 ENST00000305218(uc001nyj.3 uc001nyk.1 uc010rnb.1)
    ENST00000536973 ENST00000538945 ENST00000543847 ENST00000540736 ENST00000540501
    ENST00000544739 ENST00000537479 ENST00000538497 ENST00000540887 ENST00000355603

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate STIP1:
    hsa-miR-892b hsa-miR-324-3p hsa-miR-591 hsa-miR-3202 hsa-miR-2278 hsa-miR-3616-3p hsa-miR-4267 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSTIP1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat STIP1
      QuantiFast Probe-based Assays in human, mouse, rat STIP1

    Additional mRNA sequence: 

    AK225736.1 AK291555.1 AK297319.1 BC002987.1 BC039299.1 BT020010.1 BT020011.1 CR536512.1 
    M86752.1 

    Selected DOTS entries (see all 29):

    DT.451602  DT.100882073  DT.95374467  DT.97775969  DT.95374463  DT.100882075  DT.120739457  DT.120739511 
    DT.95374458  DT.95374465  DT.100038988  DT.120739452  DT.95374455  DT.120739455  DT.120739492  DT.99938805 
    DT.100882085  DT.95374456  DT.95374459  DT.97860864  DT.100882079  DT.100882082  DT.101961882  DT.120739500 

    Selected AceView cDNA sequences (see all 739):

    BQ951469 BX103346 CB129119 AA830064 CF131496 BU179332 BM558495 BU931084 
    BF818665 BM742873 BQ948412 BQ070547 BG387809 BM554870 BM743352 CA405445 
    AL710998 BM758094 BM045693 AL711016 AI752579 BG769542 BM763322 BU521849 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STIP1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ·
    SP1:        -     -     -     -     -                                         -     -                                                                           
    SP2:                          -     -                                         -     -                                                                           
    SP3:                                                                                                                                                            
    SP4:                          -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP5:                                                                                                                                                            

    ExUns: 18c · 18d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for STIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGGGGAG
    STIP1 Expression
    About this image


    STIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)
    STIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.337295
        Custom PCR Arrays for STIP1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat STIP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STIP1 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stip11 , 5 stress-induced phosphoprotein 11, 5 87.85(n)1
    96.87(a)1
      19 (5.15 cM)5
    208671  NM_016737.21  NP_058017.11 
     70206965 
    chicken
    (Gallus gallus)
    Aves LOC1017480851 stress-induced-phosphoprotein 1-like 71.19(n)
    76.61(a)
      101748085  XM_004950971.1  XP_004951028.1 
    lizard
    (Anolis carolinensis)
    Reptilia STIP16
    stress-induced-phosphoprotein 1
    88(a)
    1 ↔ 1
    GL343555.1(358345-371198)
    African clawed frog
    (Xenopus laevis)
    Amphibia stip1-prov2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing more 75.78(n)    BC046709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290812 Transcribed sequence with moderate similarity to protein more 78.76(n)    CK239651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hop1 , 3 Hsp70/Hsp90 organizing protein3
    Hsp70/Hsp90 organizing protein homolog1
    44(a)3
    60.54(n)1
    56.37(a)1
      21B83
    332021  NM_058006.41  NP_477354.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R09E12.33
    sti-11
    sti-11 56(a)3
    59.28(n)1
    56.96(a)1
      V(773421-774545)3
    1785871  NM_070921.61  NP_503322.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STI1(YOR027W)4
    STI11
    Hsp90 cochaperone, interacts with the Ssa group of more4
    STI11
    49.88(n)1
    41.79(a)1
      15(381053-382822)4
    8541921, 4  NP_014670.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G122701 AT1G12270 52.2(n)
    47.3(a)
      837781  NM_101099.4  NP_172691.1 
    rice
    (Oryza sativa)
    Liliopsida Os.134612 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.68(n)    AK102431.1 


    ENSEMBL Gene Tree for STIP1 (if available)
    TreeFam Gene Tree for STIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STIP1 gene
    TTC312  
    3 SIMAP similar genes for STIP1 using alignment to 7 protein entries:     STIP1_HUMAN (see all proteins):
    SGTB    TTC12    DNAJC7

    Find genes that share paralogs with STIP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for STIP1
    PGOHUM00000259808 PGOHUM00000259812 PGOHUM00000241423


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STIP1 (see all 499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354846051,2
    C--60296125(+) TGGTC-/GTGT/T
            
    GTGTG
    1 -- int10--------
    rs30474951,2
    C--63951721(+) ggggg-/G/GG  
            
    atcac
    1 -- us2k1 tfbs3 trp31NA 2
    rs573017431,2
    C--63951734(+) GGGGG-/G/GGG 
            
    ATCAC
    2 -- us2k1 cds11NA 2
    rs1920893111,2
    --63951827(+) GGTGGC/TGCACA 1 -- us2k10--------
    rs1853456731,2
    --63951903(+) GCAGGA/GAGCCG 1 -- us2k10--------
    rs574111191,2
    C--63951996(+) CAAAAC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs127992491,2
    C,F--63951999(+) AAAAAC/AAAACA 1 -- us2k1 trp35Minor allele frequency- A:0.40NA WA CSA 10
    rs1998784061,2
    C--63952003(+) AAAAAA/CAAAAA 1 -- us2k10--------
    rs1996197221,2
    --63952005(+) AACAA-/CAAAAA 1 -- us2k10--------
    rs729203451,2
    C--63952006(+) AACAAC/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for STIP1 (63952744 - 63972020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for STIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1165n71CNV Loss21882294
    dgv15n68CNV Loss17160897
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195
    nsv897663CNV Loss21882294
    nsv825943CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for STIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605063    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for STIP1:
    Childhood absence epilepsy

    Find genes that share disorders with STIP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for STIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 51.9 12 8776728 (2), 11281722 (1), 16894550 (1), 17267421 (1) (see all 8)

    Genetic Association Database (GAD): STIP1
    Human Genome Epidemiology (HuGE) Navigator: STIP1 (3 documents)

    Export disorders for STIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for STIP1 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with STIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress- inducible yeast protein STI1. (PubMed id 1569099)1, 2, 3, 9 Honore B....Celis J.E. (J. Biol. Chem. 1992)
    2. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4, 9 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)
    3. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PubMed id 10786835)1, 2, 9 Scheufler C.... Moarefi I. (Cell 2000)
    4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    5. Genome-wide association study of the child behavior checklist dysregulation profile. (PubMed id 21784300)1, 4 Mick E....Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011)
    6. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    10. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10963 HGNC: 11387 AceView: STIP1 Ensembl:ENSG00000168439 euGenes: HUgn10963
    ECgene: STIP1 Kegg: 10963 H-InvDB: STIP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for STIP1 gene:
    Search GeneIP for patents involving STIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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