STIP1 Gene

Aliases
for STIP1 gene

Previous GC identifers: GC11P066389 GC11M065612 GC11P064203 GC11P063728 GC11P063729 GC11P063709 GC11P060283

Summaries
for STIP1 gene

Genomic Views
for STIP1 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_167190.1  

SwitchGear Promoter luciferase reporter plasmid: STIP1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STIP1

STIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063953:  view genomic region     (about GC identifiers)

Proteins
for STIP1 gene

5 PDB 3D structures from and Proteopedia for STIP1:

1ELR (3D)        1ELW (3D)        2LNI (3D)        3ESK (3D)        3FWV (3D)    

Explore the universe of human proteins at neXtProt for STIP1: NX_P31948

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for STIP1
	OriGene Purified Protein: STIP1 OriGene Protein Over-expression Lysate: STIP1 OriGene Custom Protein Services for STIP1
	GenScript Custom Purified and Recombinant Proteins Services for STIP1
	Novus Biologicals STIP1 Proteins Novus Biologicals STIP1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for STIP1
	Uscn Proteins for STIP1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of STIP1
	R&D Systems Antibodies for STIP1 (STI1)
	Cell Signaling Technology (CST) Antibodies for STIP1  (STI1)
	OriGene Antibodies (see all 2): STIP1 OriGene Custom Antibody Services for STIP1
	GenScript Custom Superior Antibodies Services for STIP1
	Novus Biologicals STIP1 Antibodies
	Abcam antibodies for STIP1
	Uscn Antibodies for STIP1
	ThermoFisher Antibody for STIP1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for STIP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STIP1

Protein Domains /
Families
for STIP1 gene

ProtoNet protein and cluster: P31948

Function
for STIP1 gene

miRNA Products:		OriGene 3'-UTR Clone: STIP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STIP1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate STIP1:
		hsa-miR-892b hsa-miR-324-3p hsa-miR-591 hsa-miR-3202 hsa-miR-2278 hsa-miR-3616-3p hsa-miR-4267 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: STIP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STIP1 (see all 7) OriGene shRNA RFP: STIP1 OriGene siRNA: STIP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STIP1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for STIP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STIP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STIP1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STIP1 (NM_006819)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STIP1
		Search LifeMap BioReagents cell lines for STIP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIP1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for STIP1 gene

	Super-pathway	contained gene-specific pathways
1	Axon guidance	Axon guidance 1.00 L1CAM interactions 0.39 Developmental Biology 0.69
2	Protein Stability	Protein Stability 1.00
3	CHL1 interactions	CHL1 interactions 1.00
4	Prion diseases	Prion diseases 1.00

1 Cell Signaling Technology (CST) Pathway for STIP1

Protein Stability

4        Reactome Pathways for STIP1

	L1CAM interactions
	Developmental Biology
	CHL1 interactions
	Axon guidance

1         Kegg Pathway  (Kegg details for STIP1)

Prion diseases

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for STIP1 gene

Transcripts
for STIP1 gene

Expression
for STIP1 gene

STIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATGGGGAG

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyMetanephric MesenchymeMetanephric Mesenchyme Cells			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STIP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STIP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STIP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STIP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIP1

Orthologs
for STIP1 gene

Paralogs
for STIP1 gene

Paralogs for STIP1 gene

RPAP3²  TOMM34²  TTC1²  SPAG1²  

2 SIMAP similar genes for STIP1 using alignment to 7 protein entries:     STIP1_HUMAN (see all proteins):

SGTB    TTC12

STIP1 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for STIP1
PGOHUM00000259808 PGOHUM00000259812 PGOHUM00000241423

Genomic Variants
for STIP1 gene

10/385 NCBI SNPs in STIP1 are shown (see all 385)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1920893111,2		--	63951827(+)	GGTGGC/TGCACA	1	--	us2k1		0	--	--	--	--
rs1853456731,2		--	63951903(+)	GCAGGA/GAGCCG	1	--	us2k1		0	--	--	--	--
rs574111191,2	C	--	63951996(+)	CAAAAC/AAAAAA	1	--	us2k1		1		WA	2
rs127992491,2	C,F,	--	63951999(+)	AAAAAC/AAAACA	1	--	us2k1 trp3		5		NA WA CSA	10
rs1996197221,2		--	63952005(+)	AACAA-/CAAAAA	1	--	us2k1		0	--	--	--	--
rs710457431,2	C,	--	63952006(+)	ACAAAC/-AAAAA	1	--	us2k1		2		NA CSA	4
rs729203451,2	C,	--	63952006(+)	AACAAC/AAAAAA	1	--	us2k1		1		NA	2
rs1999416971,2		--	63952007(+)	CAAAA-/ACAAAAA	1	--	us2k1		0	--	--	--	--
rs1996938151,2		--	63952081(+)	GAGGT-/GGGAGG	1	--	us2k1		0	--	--	--	--
rs1878682671,2		--	63952243(+)	CCCATC/TCTAAA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for STIP1 (63952744 - 63972020 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STIP1
     1 CNV: 4751

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STIP1

DNA2.0 Custom Variant and Variant Library Synthesis for STIP1

Disorders / Diseases
for STIP1 gene

9 diseases for STIP1

1 Novoseek disease relationship for STIP1 gene    About this table

Publications
for STIP1 gene

PubMed articles for STIP1 gene, integrated from 9 sources (see all 106): (articles sorted by number of sources associating them with STIP1)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress- inducible yeast protein STI1. (PubMed id 1569099)^{1, 2, 3, 9} Honore B....Celis J.E. (1992)
2. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PubMed id 10786835)^{1, 2, 9} Scheufler C.... Moarefi I. (2000)
3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)^{1, 2} Imai Y.... Takahashi R. (2003)
6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2} Scanlan M.J....Old L.J. (1999)
7. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)^{1, 2} Rasmussen H.H....Vandekerckhove J. (1992)
8. Structural studies on the co-chaperone Hop and its complexes with Hsp90. (PubMed id 18485364)^{1, 9} Onuoha S.C....Jackson S.E. (2008)
9. Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation. (PubMed id 15632128)^{1, 9} Carrigan P.E....Smith D.F. (2005)
10. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)^{1, 9} Hawkins G.A....Bleecker E.R. (2009)

External Searches for STIP1 gene

Genome Databases showing STIP1 gene

Other Databases showing STIP1 gene

Specialized Databases showing STIP1 gene

Products
for STIP1 gene