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Aliases for STIMATE Gene

Aliases for STIMATE Gene

  • STIM Activating Enhancer 2 3
  • Transmembrane Protein 110 2 3 4 5
  • TMEM110 3 4 5
  • STIM-Activating Enhancer Encoded By TMEM110 3 4
  • Store-Operated Calcium Entry Regulator STIMATE 3

External Ids for STIMATE Gene

Previous HGNC Symbols for STIMATE Gene

  • TMEM110

Summaries for STIMATE Gene

GeneCards Summary for STIMATE Gene

STIMATE (STIM Activating Enhancer) is a Protein Coding gene. Diseases associated with STIMATE include Ascaridiasis. An important paralog of this gene is TMEM110-MUSTN1.

UniProtKB/Swiss-Prot for STIMATE Gene

  • Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).

Additional gene information for STIMATE Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STIMATE Gene

Genomics for STIMATE Gene

GeneHancer (GH) Regulatory Elements for STIMATE Gene

Promoters and enhancers for STIMATE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052896 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 307 1.9 HDGF ATF1 RB1 SIN3A ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 ATF7 TMEM110-MUSTN1 STIMATE ITIH4 ITIH3 ENSG00000279144
GH03I052769 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.4 +126.7 126709 2.1 HDGF FOXA2 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B NEK4 PBRM1 RRP9 RFT1 ITIH3 ITIH4-AS1 ENSG00000243696 ITIH4 SNORD69 GNL3
GH03I053043 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.6 -147.7 -147693 3.9 CLOCK FOXA2 ARNT SIN3A ZNF766 GLIS2 ZNF207 ZNF143 ATF7 ZNF263 SFMBT1 GC03P053048 ITIH4 RFT1 PBRM1 STIMATE SNORD19B PRKCD ITIH3 LOC105377135
GH03I053071 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.2 -175.4 -175404 2.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 ZNF207 ZNF143 RXRA RFT1 ITIH4 STIMATE ITIH1 TMEM110-MUSTN1 ENSG00000243696 MUSTN1 SFMBT1 DCP1A GC03M053066
GH03I052778 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.9 +117.9 117850 2.3 PKNOX1 MAX EBF1 YY1 POLR2A ATF7 IKZF2 SMARCA5 ZNF687 RXRA ITIH1 ITIH4 PBRM1 ENSG00000243696 MUSTN1 TMEM110-MUSTN1 STIMATE WDR82 ITIH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STIMATE on UCSC Golden Path with GeneCards custom track

Genomic Locations for STIMATE Gene

Genomic Locations for STIMATE Gene
chr3:52,836,219-52,897,596
(GRCh38/hg38)
Size:
61,378 bases
Orientation:
Minus strand
chr3:52,870,235-52,931,612
(GRCh37/hg19)

Genomic View for STIMATE Gene

Genes around STIMATE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STIMATE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STIMATE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STIMATE Gene

Proteins for STIMATE Gene

  • Protein details for STIMATE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TL2-STIMA_HUMAN
    Recommended name:
    Store-operated calcium entry regulator STIMATE
    Protein Accession:
    Q86TL2

    Protein attributes for STIMATE Gene

    Size:
    294 amino acids
    Molecular mass:
    33187 Da
    Quaternary structure:
    • Homooligomer (PubMed:26322679). Interacts with STIM1 (PubMed:26322679).

neXtProt entry for STIMATE Gene

Post-translational modifications for STIMATE Gene

No Post-translational modifications

Other Protein References for STIMATE Gene

No data available for DME Specific Peptides for STIMATE Gene

Domains & Families for STIMATE Gene

Gene Families for STIMATE Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for STIMATE Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STIMATE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TL2

UniProtKB/Swiss-Prot:

STIMA_HUMAN :
  • The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).
  • Belongs to the STIMATE family.
Domain:
  • The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).
Family:
  • Belongs to the STIMATE family.
genes like me logo Genes that share domains with STIMATE: view

Function for STIMATE Gene

Molecular function for STIMATE Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).

Phenotypes From GWAS Catalog for STIMATE Gene

Gene Ontology (GO) - Molecular Function for STIMATE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IDA 26322679
GO:0005515 protein binding IPI 26322679
genes like me logo Genes that share ontologies with STIMATE: view

Phenotypes for STIMATE Gene

genes like me logo Genes that share phenotypes with STIMATE: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STIMATE Gene

Localization for STIMATE Gene

Subcellular locations from UniProtKB/Swiss-Prot for STIMATE Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable). {ECO:0000269 PubMed:26644574, ECO:0000305 PubMed:26322679}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STIMATE gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STIMATE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 26322679
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032541 cortical endoplasmic reticulum IDA 26322679
genes like me logo Genes that share ontologies with STIMATE: view

Pathways & Interactions for STIMATE Gene

SuperPathways for STIMATE Gene

No Data Available

Interacting Proteins for STIMATE Gene

Selected Interacting proteins: Q86TL2-STIMA_HUMAN for STIMATE Gene via IID

Symbol External ID(s) Details
CIAO1
HSPH1

Gene Ontology (GO) - Biological Process for STIMATE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032237 activation of store-operated calcium channel activity IDA 26322679
GO:0035584 calcium-mediated signaling using intracellular calcium source IDA 26644574
GO:0051533 positive regulation of NFAT protein import into nucleus IDA 26644574
genes like me logo Genes that share ontologies with STIMATE: view

No data available for Pathways by source and SIGNOR curated interactions for STIMATE Gene

Drugs & Compounds for STIMATE Gene

No Compound Related Data Available

Transcripts for STIMATE Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STIMATE Gene

No ASD Table

Relevant External Links for STIMATE Gene

GeneLoc Exon Structure for
STIMATE
ECgene alternative splicing isoforms for
STIMATE

Expression for STIMATE Gene

NURSA nuclear receptor signaling pathways regulating expression of STIMATE Gene:

STIMATE

mRNA Expression by UniProt/SwissProt for STIMATE Gene:

Q86TL2-STIMA_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for STIMATE Gene

  • Nervous system(4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STIMATE Gene

Orthologs for STIMATE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STIMATE Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tmem110 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM110 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM110 34
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2630 33
zebrafish
(Danio rerio)
Actinopterygii tmem110 34
  • 72 (a)
OneToMany
zgc63630 33
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL091C 33
  • 45.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL162C 33
  • 44.85 (n)
-- 34
  • 26 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10076g 33
  • 44.08 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02834 33
  • 47.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for STIMATE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STIMATE Gene

ENSEMBL:
Gene Tree for STIMATE (if available)
TreeFam:
Gene Tree for STIMATE (if available)

Paralogs for STIMATE Gene

Paralogs for STIMATE Gene

genes like me logo Genes that share paralogs with STIMATE: view

Variants for STIMATE Gene

Sequence variations from dbSNP and Humsavar for STIMATE Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000004747 -- 52,842,960(-) C/A coding_sequence_variant
rs1000017797 -- 52,851,605(-) C/A intron_variant
rs1000030087 -- 52,840,397(-) G/A 3_prime_UTR_variant
rs1000117991 -- 52,846,084(-) C/T intron_variant
rs1000142464 -- 52,891,788(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STIMATE Gene

Variant ID Type Subtype PubMed ID
esv2762328 CNV loss 21179565
esv3596163 CNV gain 21293372
nsv508928 CNV insertion 20534489
nsv834698 CNV gain 17160897

Variation tolerance for STIMATE Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STIMATE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STIMATE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIMATE Gene

Disorders for STIMATE Gene

MalaCards: The human disease database

(1) MalaCards diseases for STIMATE Gene - From: DISEASES

Disorder Aliases PubMed IDs
ascaridiasis
  • ascariasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STIMATE

genes like me logo Genes that share disorders with STIMATE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STIMATE Gene

Publications for STIMATE Gene

  1. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx. (PMID: 26322679) Jing J … Zhou Y (Nature cell biology 2015) 2 3 4 58
  2. TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling. (PMID: 26644574) Quintana A … Hogan PG (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  5. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 58

Products for STIMATE Gene

Sources for STIMATE Gene

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