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Aliases for STIM2 Gene

Aliases for STIM2 Gene

  • Stromal Interaction Molecule 2 2 3 5
  • KIAA1482 4

External Ids for STIM2 Gene

Previous GeneCards Identifiers for STIM2 Gene

  • GC04P027012
  • GC04P026550
  • GC04P026613
  • GC04P026538
  • GC04P026472
  • GC04P026200

Summaries for STIM2 Gene

Entrez Gene Summary for STIM2 Gene

  • This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

GeneCards Summary for STIM2 Gene

STIM2 (Stromal Interaction Molecule 2) is a Protein Coding gene. Diseases associated with STIM2 include Stormorken Syndrome and Myopathy, Tubular Aggregate, 1. Among its related pathways are Ca, cAMP and Lipid Signaling and Calcium signaling pathway. GO annotations related to this gene include calcium ion binding and store-operated calcium channel activity. An important paralog of this gene is MIR4687.

UniProtKB/Swiss-Prot for STIM2 Gene

  • Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

Tocris Summary for STIM2 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Gene Wiki entry for STIM2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STIM2 Gene

Genomics for STIM2 Gene

Regulatory Elements for STIM2 Gene

Enhancers for STIM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F026881 1.4 FANTOM5 Ensembl ENCODE 43.4 +27.0 27023 7.0 MXI1 PKNOX1 MTA2 ZBED1 JUNB BMI1 TBX21 GABPA PBX2 IKZF1 STIM2 LOC105374546 TBC1D19 LOC100421493 GC04P026973
GH04F026991 1.5 FANTOM5 Ensembl ENCODE 26.1 +135.7 135735 3.4 BMI1 ZBTB40 GATA2 EGR1 CREM EGR2 JUNB TBX21 SP1 SMARCA4 STIM2 LOC105374546 GC04P026984 GC04M027054
GH04F026821 1.2 Ensembl ENCODE 19.6 -35.3 -35278 1.6 ELF3 TBP PKNOX1 MLX ARID4B DMAP1 ZNF48 RAD21 DNMT3B RARA STIM2 GC04P026778
GH04F026826 1.1 Ensembl ENCODE 18.2 -30.9 -30878 1.6 MXI1 TBL1XR1 BMI1 RELA CBX5 EGR1 EED ETV6 CREM CHD2 STIM2 GC04P026778
GH04F026786 1.1 Ensembl ENCODE 16.1 -69.9 -69947 3.5 RAD21 ZNF766 GATA2 FOS ZEB2 REST NR2F2 TFDP1 GLIS1 KDM1A STIM2 GC04P026778
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STIM2 on UCSC Golden Path with GeneCards custom track

Promoters for STIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001858654 223 2200 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for STIM2 Gene

Chromosome:
4
Start:
26,857,678 bp from pter
End:
27,025,381 bp from pter
Size:
167,704 bases
Orientation:
Plus strand

Genomic View for STIM2 Gene

Genes around STIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STIM2 Gene

Proteins for STIM2 Gene

  • Protein details for STIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P246-STIM2_HUMAN
    Recommended name:
    Stromal interaction molecule 2
    Protein Accession:
    Q9P246
    Secondary Accessions:
    • A6H8L7
    • B7ZVY0
    • Q96BF1
    • Q9BQH2
    • Q9H8R1

    Protein attributes for STIM2 Gene

    Size:
    746 amino acids
    Molecular mass:
    83971 Da
    Quaternary structure:
    • Oligomer with STIM1. Interacts with ORAI1.
    SequenceCaution:
    • Sequence=BAA96006.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=BAB14545.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14545.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB66512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STIM2 Gene

    Alternative splice isoforms for STIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STIM2 Gene

Post-translational modifications for STIM2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STIM2 (STIM2)
  • Abcam antibodies for STIM2

No data available for DME Specific Peptides for STIM2 Gene

Domains & Families for STIM2 Gene

Gene Families for STIM2 Gene

Protein Domains for STIM2 Gene

Suggested Antigen Peptide Sequences for STIM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P246

UniProtKB/Swiss-Prot:

STIM2_HUMAN :
  • Contains 1 EF-hand domain.
Domain:
  • Contains 1 EF-hand domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with STIM2: view

Function for STIM2 Gene

Molecular function for STIM2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

Gene Ontology (GO) - Molecular Function for STIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IEA,IMP 18160041
GO:0005509 calcium ion binding IDA 18166150
GO:0005515 protein binding IPI 11463338
GO:0015279 store-operated calcium channel activity IDA 16860747
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STIM2: view
genes like me logo Genes that share phenotypes with STIM2: view

Animal Models for STIM2 Gene

MGI Knock Outs for STIM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for STIM2

miRNA for STIM2 Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STIM2 Gene

Localization for STIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STIM2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STIM2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for STIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 18160041
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA,IDA 18160041
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STIM2: view

Pathways & Interactions for STIM2 Gene

genes like me logo Genes that share pathways with STIM2: view

Pathways by source for STIM2 Gene

1 Cell Signaling Technology pathway for STIM2 Gene
1 KEGG pathway for STIM2 Gene

Gene Ontology (GO) - Biological Process for STIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0006874 cellular calcium ion homeostasis IMP 18160041
genes like me logo Genes that share ontologies with STIM2: view

No data available for SIGNOR curated interactions for STIM2 Gene

Drugs & Compounds for STIM2 Gene

(1) Drugs for STIM2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SKF 96365 hydrochloride Pharma SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry 0

(1) Tocris Compounds for STIM2 Gene

Compound Action Cas Number
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
genes like me logo Genes that share compounds with STIM2: view

Transcripts for STIM2 Gene

Unigene Clusters for STIM2 Gene

Stromal interaction molecule 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STIM2 Gene

No ASD Table

Relevant External Links for STIM2 Gene

GeneLoc Exon Structure for
STIM2
ECgene alternative splicing isoforms for
STIM2

Expression for STIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STIM2 Gene

Protein differential expression in normal tissues from HIPED for STIM2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.4) and Breast (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STIM2 Gene



Protein tissue co-expression partners for STIM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STIM2 Gene:

STIM2

SOURCE GeneReport for Unigene cluster for STIM2 Gene:

Hs.744950

mRNA Expression by UniProt/SwissProt for STIM2 Gene:

Q9P246-STIM2_HUMAN
Tissue specificity: Expressed in all tissues and tumor cell lines examined.
genes like me logo Genes that share expression patterns with STIM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STIM2 Gene

Orthologs for STIM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STIM2 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia STIM2 34 35
  • 91.56 (n)
cow
(Bos Taurus)
Mammalia STIM2 34 35
  • 91.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STIM2 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Stim2 34 16 35
  • 85.84 (n)
rat
(Rattus norvegicus)
Mammalia Stim2 34
  • 85.28 (n)
chicken
(Gallus gallus)
Aves STIM2 34 35
  • 79.13 (n)
lizard
(Anolis carolinensis)
Reptilia STIM2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stim2 34
  • 73.09 (n)
zebrafish
(Danio rerio)
Actinopterygii stim2b 34 35
  • 63.42 (n)
STIM2 (2 of 2) 35
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Stim 36 35
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55B1BM.1b 36
  • 29 (a)
Y55B1BM.1a 36
  • 28 (a)
stim-1 35
  • 25 (a)
OneToMany
Species where no ortholog for STIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STIM2 Gene

ENSEMBL:
Gene Tree for STIM2 (if available)
TreeFam:
Gene Tree for STIM2 (if available)

Paralogs for STIM2 Gene

Paralogs for STIM2 Gene

genes like me logo Genes that share paralogs with STIM2: view

Variants for STIM2 Gene

Sequence variations from dbSNP and Humsavar for STIM2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002654 -- 26,955,142(+) AAAAG(C/T)TTTAA intron-variant
rs10003072 -- 26,941,951(+) AGAAG(A/G)CAATG intron-variant
rs10004120 -- 26,950,708(+) AGTTA(C/T)TCTGT intron-variant
rs10006403 -- 26,872,078(+) TAACC(A/G)TTATT intron-variant
rs10007132 -- 26,990,554(+) gacct(C/G)aaaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STIM2 Gene

Variant ID Type Subtype PubMed ID
nsv822513 CNV loss 20364138
nsv593880 CNV loss 21841781
nsv593872 CNV loss 21841781
nsv470021 CNV loss 18288195
nsv461312 CNV loss 19166990
esv3599996 CNV loss 21293372
esv3599995 CNV loss 21293372
esv3563592 CNV deletion 23714750
esv2662300 CNV deletion 23128226
esv2570509 CNV deletion 19546169
esv23369 CNV loss 19812545
esv2334135 CNV deletion 18987734
esv1919348 CNV deletion 18987734
esv1000535 CNV deletion 20482838
dgv8995n54 CNV loss 21841781
dgv8994n54 CNV loss 21841781
dgv8993n54 CNV loss 21841781
dgv139n6 CNV deletion 16902084

Variation tolerance for STIM2 Gene

Residual Variation Intolerance Score: 3.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.92; 79.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STIM2 Gene

Disorders for STIM2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STIM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stormorken syndrome
  • thrombocytopathy, asplenia and miosis
myopathy, tubular aggregate, 1
  • myeloproliferative syndrome, transient
- elite association - COSMIC cancer census association via MalaCards
Search STIM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STIM2

Genetic Association Database (GAD)
STIM2
Human Genome Epidemiology (HuGE) Navigator
STIM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STIM2
genes like me logo Genes that share disorders with STIM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STIM2 Gene

Publications for STIM2 Gene

  1. STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. (PMID: 17905723) Parvez S. … Penner R. (FASEB J. 2008) 3 4 22 64
  2. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. (PMID: 11463338) Williams R.T. … Dziadek M.A. (Biochem. J. 2001) 2 3 4 64
  3. STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion. (PMID: 23359669) Thiel M. … Penner R. (J. Physiol. (Lond.) 2013) 3 4 64
  4. Auto-inhibitory role of the EF-SAM domain of STIM proteins in store- operated calcium entry. (PMID: 21217057) Zheng L. … Ikura M. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  5. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre R.N. … Steffen L.M. (PLoS Genet. 2011) 3 46 64

Products for STIM2 Gene

Sources for STIM2 Gene

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