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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STIM2 Gene

protein-coding   GIFtS: 59
GCID: GC04P026859

Stromal Interaction Molecule 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Stromal Interaction Molecule 21 2
KIAA14823 5

External Ids:    HGNC: 192051   Entrez Gene: 576202   Ensembl: ENSG000001096897   OMIM: 6108415   UniProtKB: Q9P2463   

Export aliases for STIM2 gene to outside databases

Previous GC identifers: GC04P027012 GC04P026550 GC04P026613 GC04P026538 GC04P026472 GC04P026200


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STIM2 Gene:
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related
family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium
concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane
Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is
cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. (provided by
RefSeq, Dec 2009)

GeneCards Summary for STIM2 Gene: 
STIM2 (stromal interaction molecule 2) is a protein-coding gene. Diseases associated with STIM2 include alzheimer's disease, and neuronitis. GO annotations related to this gene include store-operated calcium channel activity and calcium ion binding. An important paralog of this gene is STIM1.

UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of
intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which
activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic
reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration,
translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+)
release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx

summary for STIM2 Gene:
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated
calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the
emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and
STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to
the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma
membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and
Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed
in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of
Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium
channel.

Gene Wiki entry for STIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006316.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STIM2 gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   E2F-5   Nkx2-5   E2F-2   Ik-3   E2F-1   E2F   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

STIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STIM2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P026859:  view genomic region     (about GC identifiers)

Start:
26,859,300 bp from pter      End:
27,027,003 bp from pter
Size:
167,704 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246 (See protein sequence)
Recommended Name: Stromal interaction molecule 2 precursor  
Size: 746 amino acids; 83971 Da
Subunit: Oligomer with STIM1. Interacts with ORAI1
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically
translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane
junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration
Sequence caution: Sequence=BAA96006.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator
methionine is coded by a non-canonical CTG leucine codon; Sequence=BAB14545.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB14545.1; Type=Miscellaneous discrepancy; Note=Probable
cloning artifact; Sequence=CAB66512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator
methionine is coded by a non-canonical CTG leucine codon;
1 PDB 3D structure from and Proteopedia for STIM2:
2L5Y (3D)    
Secondary accessions: Q96BF1 Q9BQH2 Q9H8R1

Explore the universe of human proteins at neXtProt for STIM2: NX_Q9P246

Explore proteomics data for STIM2 at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated
  • UniProtKB: Phosphorylated predominantly on Ser residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P246

  • STIM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STIM2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001162588.1  NP_001162589.1  NP_065911.3  

    ENSEMBL proteins: 
     ENSP00000473527   ENSP00000473283   ENSP00000419073   ENSP00000419383   ENSP00000417569  
     ENSP00000473581   ENSP00000420113   ENSP00000419536   ENSP00000371439   ENSP00000237364  
     ENSP00000404812  

    Human Recombinant Protein Products for STIM2: 
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    OriGene MassSpec for STIM2 
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    Novus Biologicals STIM2 Proteins
    Novus Biologicals STIM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STIM2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18160041
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IDA18160041
    GO:0016021integral to membrane IEA--

    STIM2 for ontologies           About GeneDecksing



    STIM2 Antibody Products: 
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    ThermoFisher Antibodies for STIM2
    LSBio Antibodies in human, mouse, rat for STIM2 

    Assay Products for STIM2: 
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    Cloud-Clone Corp. ELISAs for STIM2 
    Cloud-Clone Corp. CLIAs for STIM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SAMD: Sterile alpha motif (SAM) domain containing

    3 InterPro protein domains:
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry Q9P246

    ProtoNet protein and cluster: Q9P246

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    STIM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STIM2_HUMAN, Q9P246
    Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of
    intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which
    activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic
    reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration,
    translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+)
    release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005246calcium channel regulator activity IMP18160041
    GO:0005509calcium ion binding IDA18166150
    GO:0005515protein binding IPI11463338
    GO:0015279store-operated calcium channel activity IDA16860747
         
    STIM2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Stim2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  vision/eye 

    STIM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stim2tm1.1Rao for STIM2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STIM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STIM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STIM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STIM2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STIM2
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate STIM2 (see all 98):
    hsa-miR-549 hsa-miR-579 hsa-miR-3678-3p hsa-miR-100* hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-411 hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidSTIM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STIM2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): STIM2 (NM_020860)
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                         Customized lentivirus expression plasmids for stable overexpression of STIM2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STIM2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1"Ca, cAMP and Lipid Signaling"
    "Ca, cAMP and Lipid Signaling"
    2Calcium signaling pathway
    Calcium signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for STIM2
        Ca, cAMP and Lipid Signaling


    1         Kegg Pathway  (Kegg details for STIM2):
        Calcium signaling pathway


    STIM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for STIM2 (Q9P2461, 2, 3 ENSP000004048124) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61871 I2D: score=2 
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    STIM1Q135861, 3, ENSP000003007374EBI-448891,EBI-448878 I2D: score=2 STRING: ENSP00000300737
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis IMP18160041
    GO:0032237activation of store-operated calcium channel activity IMP18160041
    GO:0051928positive regulation of calcium ion transport IMP18160041

    STIM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for STIM2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 96365 hydrochlorideTRPC channel blocker; also inhibits store-operated Ca2+ entry[130495-35-1]

    Search CenterWatch for drugs/clinical trials and news about STIM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STIM2 gene (3 alternative transcripts): 
    NM_001169117.1  NM_001169118.1  NM_020860.3  

    Unigene Cluster for STIM2:

    Stromal interaction molecule 2
    Hs.744950  [show with all ESTs]
    Unigene Representative Sequence: NM_001169117
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494628 ENST00000463501 ENST00000478425 ENST00000467087 ENST00000467011
    ENST00000465503 ENST00000478049 ENST00000473519 ENST00000477474 ENST00000504511
    ENST00000382009(uc003gsh.4) ENST00000237364(uc010iex.3 uc003gsg.4 uc010iey.3)
    ENST00000412829

    miRNA
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    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate STIM2 (see all 98):
    hsa-miR-549 hsa-miR-579 hsa-miR-3678-3p hsa-miR-100* hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-411 hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidSTIM2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIM2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STIM2

    Additional mRNA sequence: 

    AB040915.1 AF328905.1 AK023369.1 AK096846.1 AL136577.1 BC015659.2 BC043604.1 BC057231.1 
    BC136449.1 BC146661.1 BC152554.1 BC171766.1 

    12 DOTS entries:

    DT.109253  DT.91858761  DT.91743443  DT.40304892  DT.100748991  DT.436684  DT.97774581  DT.100677496 
    DT.439119  DT.95232180  DT.97820808  DT.75184277 

    24/164 AceView cDNA sequences (see all 164):

    BM932168 AI627460 AK096846 BC043604 AI694503 NM_020860 AA808025 BM685168 
    AA334307 AA808325 Z41735 AU134169 AA504293 BE048395 CK430048 AA832258 
    BM729292 AW770851 BC015659 BU743230 AA642400 AW959917 AB040915 AA210942 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STIM2 expression in normal human tissues (normalized intensities)      STIM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTTGTT
    STIM2 Expression
    About this image


    STIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             bronchial epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Islets of Langerhans
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
             pancreas ; exocrine glandular cells   

    See STIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STIM2

    SOURCE GeneReport for Unigene cluster: Hs.744950

    UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
    Tissue specificity: Expressed in all tissues and tumor cell lines examined

        SABiosciences Expression via Pathway-Focused PCR Array including STIM2: 
              Hematopoiesis in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STIM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STIM2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stim21 , 5 stromal interaction molecule 21, 5 85.84(n)1
    93.43(a)1
      5 (29.69 cM)5
    1168731  NM_001081103.21  NP_001074572.21 
     539984175 
    chicken
    (Gallus gallus)
    Aves STIM21 stromal interaction molecule 2 80.51(n)
    88.39(a)
      422799  XM_420749.3  XP_420749.3 
    lizard
    (Anolis carolinensis)
    Reptilia STIM26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343348.1(841751-878725)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA789231.12   -- 77.31(n)    CA789231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stim21 stromal interaction molecule 2 62.72(n)
    65.22(a)
      563901  XM_687264.4  XP_692356.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stim3 cell adhesion 41(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y55B1BM.1b3   -- 29(a)
    (best of 2)
      III(408417-418691)   --


    ENSEMBL Gene Tree for STIM2 (if available)
    TreeFam Gene Tree for STIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STIM2 gene
    STIM12  
    1 SIMAP similar gene for STIM2 using alignment to 13 protein entries:     STIM2_HUMAN (see all proteins):
    STIM1

    STIM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2808 SNPs in STIM2 are shown (see all 2808)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs45058091,2
    C,F,A,H--26860413(+) CCCTAG/ATTCCT 3 -- us2k122Minor allele frequency- A:0.42NS EA NA WA CSA 2337
    rs1434795171,2
    C--26860507(+) AGAAG-/AAAAAA 3 -- us2k10--------
    rs1847464991,2
    --26860510(+) AAGAAA/GAAAAA 3 -- us2k10--------
    rs1906390071,2
    --26860552(+) GCCCCA/TGTGAT 3 -- us2k10--------
    rs772107701,2
    F--26860553(+) CCCCTG/CTGATT 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1440871851,2
    --26860675(+) TTTATC/TTCCTT 3 -- us2k10--------
    rs1815650411,2
    --26860729(+) TCTCAC/TAGCCC 3 -- us2k10--------
    rs746528791,2
    C,F--26864316(+) TACCAA/TTTGGG 3 -- int12Minor allele frequency- T:0.10WA NA 238
    rs793558391,2
    F--26864435(+) TAAAAA/TTGTGG 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1163099761,2
    C,F--26864468(+) TAGTGA/GTTATT 3 -- int11Minor allele frequency- G:0.08WA 118

    HapMap Linkage Disequilibrium report for STIM2 (26859300 - 27027003 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for STIM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1000535CNV Deletion20482838
    esv1919348CNV Deletion18987734
    esv2662300CNV Deletion23128226
    esv2570509CNV Deletion19546169
    esv2334135CNV Deletion18987734
    dgv139n6CNV Loss16902084
    nsv822513CNV Loss20364138
    esv23369CNV Loss19812545
    nsv470021CNV Loss18288195
    nsv461312CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610841    OMIM disorders: --

    2 diseases for STIM2:    About MalaCards
    alzheimer's disease    neuronitis


    STIM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): STIM2
    Human Genome Epidemiology (HuGE) Navigator: STIM2 (3 documents)

    Export disorders for STIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STIM2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with STIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. (PubMed id 11463338)1, 2, 3 Williams R.T.... Dziadek M.A. (2001)
    2. STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. (PubMed id 17905723)1, 2, 9 Parvez S.... Penner R. (2008)
    3. Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377)1, 4 Lemaitre R.N....Steffen L.M. (2011)
    4. Auto-inhibitory role of the EF-SAM domain of STIM proteins in store- operated calcium entry. (PubMed id 21217057)1, 2 Zheng L.... Ikura M. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics. (PubMed id 19019825)1, 2 Stathopulos P.B.... Ikura M. (2009)
    7. Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2. (PubMed id 18166150)1, 2 Zheng L.... Ikura M. (2008)
    8. STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. (PubMed id 18160041)1, 2 Brandman O.... Meyer T. (2007)
    9. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ entry. (PubMed id 16860747)1, 2 Soboloff J.... Gill D.L. (2006)
    10. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. (PubMed id 16005298)1, 2 Liou J....Meyer T. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57620 HGNC: 19205 AceView: STIM2 Ensembl:ENSG00000109689 euGenes: HUgn57620
    ECgene: STIM2 Kegg: 57620 H-InvDB: STIM2

    (According to HUGE)
    About This Section
    HUGE: KIAA1482

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STIM2 gene:
    Search GeneIP for patents involving STIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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