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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STIM2 Gene

protein-coding   GIFtS: 57
GCID: GC04P026859

stromal interaction molecule 2
 Explore 2 diseases affiliated with
STIM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STIM2    

Aliases
for STIM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Stromal Interaction Molecule 21 2
KIAA14823 5

External Ids:    HGNC: 192051   Entrez Gene: 576202   Ensembl: ENSG000001096897   OMIM: 6108415   UniProtKB: Q9P2463   

Export aliases for STIM2 gene to outside databases

Previous GC identifers: GC04P027012 GC04P026550 GC04P026613 GC04P026538 GC04P026472 GC04P026200


Summaries
for STIM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STIM2:
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family
member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the
cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels.
This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting
protein. Multiple transcript variants result from alternative splicing. (provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of
intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which
activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum
Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the
endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC)
channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx

summary for STIM2:
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated
calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the
emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and
STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to
the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma
membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and
Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed
in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of
Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium
channel.

Gene Wiki entry for STIM2


Genomic Views
for STIM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STIM2 gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   E2F-5   Nkx2-5   E2F-2   Ik-3   E2F-1   E2F   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

STIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STIM2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P026859:  view genomic region     (about GC identifiers)

Start:
 26,859,300 bp from pter      End:
 27,027,003 bp from pter
Size:
 167,704 bases      Orientation:
 plus strand

Proteins
for STIM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246 (See protein sequence)
Recommended Name: Stromal interaction molecule 2 precursor  
Size: 746 amino acids; 83971 Da
Subunit: Oligomer with STIM1. Interacts with ORAI1
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically
translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane
junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration
Sequence caution: Sequence=BAA96006.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine
is coded by a non-canonical CTG leucine codon; Sequence=BAB14545.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAB14545.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=CAB66512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a
non-canonical CTG leucine codon;
1 PDB 3D structure from and Proteopedia for STIM2:
2L5Y (3D)    
Secondary accessions: Q96BF1 Q9BQH2 Q9H8R1

Explore the universe of human proteins at neXtProt for STIM2: NX_Q9P246

Post-translational modifications:

  • Glycosylated1
  • Phosphorylated predominantly on Ser residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P246

    • STIM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001162588.1  NP_001162589.1  NP_065911.3  

    ENSEMBL proteins: 
     ENSP00000419073   ENSP00000419383   ENSP00000417569   ENSP00000420113   ENSP00000419536  
     ENSP00000371439   ENSP00000237364   ENSP00000404812  

    Human Recombinant Protein Products: 
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    Novus Biologicals STIM2 Proteins
    Novus Biologicals STIM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STIM2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18160041
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IDA18160041
    GO:0016021integral to membrane IEA--


    STIM2 for ontologies           About GeneDecksing



    STIM2 Antibody Products: 
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    Uscn ELISAs and CLIAs for STIM2

    Protein Domains /
    Families
    for STIM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STIM2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry Q9P246

    ProtoNet protein and cluster: Q9P246

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for STIM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
    Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of
    intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which
    activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum
    Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the
    endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC)
    channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STIM2
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate STIM2 (see all 98):
    hsa-miR-549 hsa-miR-579 hsa-miR-3678-3p hsa-miR-100* hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-411 hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmid: STIM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STIM2 (see all 7)
    OriGene shRNA RFP: STIM2
    OriGene siRNA: STIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STIM2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STIM2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STIM2 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 3): STIM2 (NM_020860)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIM2 

    Cell Line
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    Search LifeMap BioReagents cell lines for STIM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIM2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005246calcium channel regulator activity IMP18160041
    GO:0005509calcium ion binding IDA18166150
    GO:0005515protein binding IPI11463338
    GO:0015279store-operated calcium channel activity IDA16860747


    STIM2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Stim2tm1.1Rao for STIM2
         10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Stim2):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  vision/eye 

    STIM2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STIM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for STIM2
        Ca, cAMP and Lipid Signaling



    STIM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STIM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for STIM2 (Q9P2461, 2, 3 ENSP000004048124) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61871 I2D: score=2 
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    STIM1Q135861, 3, ENSP000003007374EBI-448891,EBI-448878 I2D: score=2 STRING: ENSP00000300737
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport ----
    GO:0006874cellular calcium ion homeostasis IMP18160041
    GO:0032235negative regulation of calcium ion transport via store-operated calcium channel activity ----
    GO:0032237activation of store-operated calcium channel activity IMP18160041
    GO:0051928positive regulation of calcium ion transport IMP18160041


    STIM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STIM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for STIM2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2-APBIP3 receptor antagonist. Also TRP channel modulator[524-95-8]
    SKF 96365 hydrochlorideSTIM1-mediated Ca2+ influx inhibitor[130495-35-1]
    ML 9 hydrochlorideMyosin light chain kinase inhibitor[105637-50-1]
    Search CenterWatch for drugs/clinical trials and news about STIM2 

    Transcripts
    for STIM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STIM2 gene (3 alternative transcripts): 
    NM_001169117.1  NM_001169118.1  NM_020860.3  

    Unigene Cluster for STIM2:

    Stromal interaction molecule 2
    Hs.135763  [show with all ESTs]
    Unigene Representative Sequence: NM_001169117
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494628 ENST00000463501 ENST00000478425 ENST00000467087 ENST00000467011
    ENST00000465503 ENST00000478049 ENST00000473519 ENST00000477474 ENST00000504511
    ENST00000382009(uc003gsh.4) ENST00000237364(uc010iex.3 uc003gsg.4 uc010iey.3)
    ENST00000412829

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STIM2
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate STIM2 (see all 98):
    hsa-miR-549 hsa-miR-579 hsa-miR-3678-3p hsa-miR-100* hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-411 hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmid: STIM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STIM2 (see all 7)
    OriGene shRNA RFP: STIM2
    OriGene siRNA: STIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STIM2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STIM2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STIM2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): STIM2 (NM_020860)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIM2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STIM2

    Additional cDNA sequence: 

    AB040915.1 AF328905.1 AK023369.1 AK096846.1 AL136577.1 BC015659.2 BC043604.1 BC057231.1 
    BC136449.1 BC146661.1 BC152554.1 BC171766.1 

    12 DOTS entries:

    DT.109253  DT.91858761  DT.91743443  DT.40304892  DT.100748991  DT.436684  DT.97774581  DT.100677496 
    DT.439119  DT.95232180  DT.97820808  DT.75184277 

    24/164 AceView cDNA sequences (see all 164):

    CK430048 AA808325 AA504293 BP352973 AB040915 BE048395 AI240742 AW959917 
    AU134169 AA642400 AI377788 AA832258 Z41735 AA808025 BC043604 AA705021 
    AA334307 AW770851 BC015659 BU743230 AA909229 BM729292 BM685168 AK096846 

    GeneLoc Exon Structure


    Expression
    for STIM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTTTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STIM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STIM2

    SOURCE GeneReport for Unigene cluster: Hs.135763

    UniProtKB/Swiss-Prot: STIM2_HUMAN, Q9P246
    Tissue specificity: Expressed in all tissues and tumor cell lines examined

        SABiosciences Expression via Pathway-Focused PCR Array including STIM2: 
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIM2

    Orthologs
    for STIM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for STIM2 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stim21 , 5 stromal interaction molecule 21, 5 85.84(n)1
    93.43(a)1    		   5 (29.69 cM)5
    1168731  NM_001081103.21  NP_001074572.21 
     539984175 
    chicken
    (Gallus gallus)    		 Aves STIM21 stromal interaction molecule 2 80.51(n)
    88.39(a)    		   422799  XM_420749.3  XP_420749.3 
    lizard
    (Anolis carolinensis)    		 Reptilia STIM26
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343348.1(841751-878724)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA789231.12   -- 77.31(n)    CA789231.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii stim21 stromal interaction molecule 2 62.72(n)
    65.22(a)    		   563901  XM_687264.4  XP_692356.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Stim3 cell adhesion 41(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y55B1BM.1b3   -- 29(a)
    (best of 2)    		   III(408417-418691)   --


    ENSEMBL Gene Tree for STIM2 (if available)
    TreeFam Gene Tree for STIM2 (if available) 

    Paralogs
    for STIM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STIM2 gene
    STIM12  
    1 SIMAP similar gene for STIM2 using alignment to 10 protein entries:     STIM2_HUMAN (see all proteins):
    STIM1

    STIM2 for paralogs           About GeneDecksing



    Genomic Variants
    for STIM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for STIM2
         7 CNVs: 6252 98659 63779 6251 80221 44153 91996
         1 Indel: 80222
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    Disorders / Diseases
    for STIM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STIM2 for disorders           About GeneDecksing

    OMIM gene information: 610841    OMIM disorders: --

    2 diseases for STIM2:    About MalaCards
    alzheimer's disease    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: STIM2 (3 documents)

    Export disorders for STIM2 gene to outside databases

    Publications
    for STIM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STIM2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with STIM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. (PubMed id 11463338)1, 2, 3 Williams R.T.... Dziadek M.A. (2001)
    2. STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. (PubMed id 17905723)1, 2, 9 Parvez S.... Penner R. (2008)
    3. Auto-inhibitory role of the EF-SAM domain of STIM proteins in store- operated calcium entry. (PubMed id 21217057)1, 2 Zheng L.... Ikura M. (2011)
    4. Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics. (PubMed id 19019825)1, 2 Stathopulos P.B.... Ikura M. (2009)
    5. Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2. (PubMed id 18166150)1, 2 Zheng L.... Ikura M. (2008)
    6. STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. (PubMed id 18160041)1, 2 Brandman O.... Meyer T. (2007)
    7. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ entry. (PubMed id 16860747)1, 2 Soboloff J.... Gill D.L. (2006)
    8. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. (PubMed id 16005298)1, 2 Liou J....Meyer T. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for STIM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing STIM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57620 HGNC: 19205 AceView: STIM2 Ensembl:ENSG00000109689 euGenes: HUgn57620
    ECgene: STIM2 H-InvDB: STIM2

    Other Databases showing STIM2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1482

    Specialized Databases showing STIM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STIM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STIM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STIM2 gene:
    Search GeneIP for patents involving STIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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