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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STIM1 Gene

protein-coding GIFtS: 69
GCID: GC11P003882

stromal interaction molecule 1

Explore 28 diseases affiliated with
STIM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Stromal Interaction Molecule 1¹ ²
GOK¹ ² ³
D11S4896E¹ ²
STIM1L²

External Ids:	HGNC: 11386¹	Entrez Gene: 6786²	Ensembl: ENSG00000167323⁷	OMIM: 605921⁵	UniProtKB: Q13586³

Export aliases for STIM1 gene to outside databases

Previous GC identifers: GC11P004429 GC11P004142 GC11P003836 GC11P003841 GC11P003833 GC11P003876 GC11P003610 GC11P003878 GC11P003880

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STIM1:

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores

by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene

domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the

Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast

cancer. This gene may play a role in malignancies and disease that involve this region, as well as early

hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with

the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1

gene.(provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: STIM1_HUMAN, Q13586

Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of

intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+)

depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+)

release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1

summary for STIM1:

STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated

calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the

emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and

STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to

the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma

membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and

Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed

in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of

Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium

channel.

Gene Wiki entry for STIM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STIM1 gene promoter:
SRF MAZR AP-1 SRF (504 AA) ATF-2 FOXJ2 (long isoform) FOXJ2 c-Jun NF-kappaB1 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STIM1 promoter sequence

Search SABiosciences Chromatin IP Primers for STIM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STIM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5

STIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STIM1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P003882: view genomic region (about GC identifiers)

Start:	3,875,757 bp from pter	End:	4,114,440 bp from pter
Size:	238,684 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STIM1_HUMAN, Q13586 (See protein sequence)

Recommended Name: Stromal interaction molecule 1 precursor

Size: 685 amino acids; 77423 Da

Subunit: Forms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably

required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct

and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+),

the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation

of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1. Interacts with ASPH

(isoform 8)

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell

membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing

distal tip of microtubules

Miscellaneous: Transfection of STIM1 into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not

express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of

rhabdomyosarcomas and rhabdoid tumors

2 PDB 3D structures from and Proteopedia for STIM1:

2K60 (3D)

3TEQ (3D)

Secondary accessions: Q8N382

Explore the universe of human proteins at neXtProt for STIM1: NX_Q13586

Post-translational modifications:

Glycosylation is required for cell surface expression¹

Phosphorylated predominantly on Ser residues¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13586

STIM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003147.2

ENSEMBL proteins:

ENSP00000432210 ENSP00000300737 ENSP00000436208 ENSP00000434848 ENSP00000433949

ENSP00000431878 ENSP00000434200 ENSP00000431191 ENSP00000432378 ENSP00000432383

ENSP00000434767 ENSP00000433266

Reactome Protein details: Q13586
Human Recombinant Protein Products for STIM1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: STIM1 OriGene Protein Over-expression Lysate: STIM1 OriGene Custom Protein Services for STIM1
	GenScript Custom Purified and Recombinant Proteins Services for STIM1
	Novus Biologicals STIM1 Proteins Novus Biologicals STIM1 Lysates
	Sino Biological Recombinant Protein for STIM1
	ProSpec Recombinant Protein for STIM1
	Uscn Proteins for STIM1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005874	microtubule	IEA	--
GO:0005887	integral to plasma membrane	IDA	16208375
GO:0030176	integral to endoplasmic reticulum membrane	IDA	--

STIM1 for ontologies About GeneDecksing

STIM1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of STIM1
	R&D Systems Antibodies for STIM1
	Cell Signaling Technology (CST) Antibodies for STIM1
	OriGene Antibodies (see all 3): STIM1 OriGene Custom Antibody Services for STIM1
	GenScript Custom Superior Antibodies Services for STIM1
	Novus Biologicals STIM1 Antibodies
	Abcam antibodies for STIM1
	Uscn Antibodies for STIM1
	ThermoFisher Antibody for STIM1

Assay Products for STIM1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for STIM1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STIM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STIM1 for domains About GeneDecksing

3 InterPro domains/families:

IPR013761 SAM/pointed

IPR001660 SAM

IPR011510 SAM_2

Graphical View of Domain Structure for InterPro Entry Q13586

ProtoNet protein and cluster: Q13586

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: STIM1_HUMAN, Q13586

Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the

growing microtubule plus ends

Domain: The STIM1 Orai1-activating region/CRAC-activating domain (SOAR/CAD) mediates interaction with ORAI1 to activate

the channel

Similarity: Contains 1 EF-hand domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STIM1_HUMAN, Q13586

Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of

intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+)

depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+)

release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1

Genatlas biochemistry entry for STIM1:

stromal interaction molecule 1,highly expressed in skeletal muscle,inhibiting rhabdomyosarcoma and rhabdoid tumor

development,would be different from SCTZ104

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IDA	16005298
GO:0005515	protein binding	IPI	--
GO:0042802	identical protein binding	IPI	--
GO:0051010	microtubule plus-end binding	IDA	19632184

STIM1 for ontologies About GeneDecksing

Phenotypes:
12 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Stim1):

cardiovascular system	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	nervous system	respiratory system
skeleton	vision/eye

STIM1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for STIM1: Stim1^tm1.1Kuro Stim1^tm1.1Rao

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STIM1

miRNA Products:		OriGene 3'-UTR Clone: STIM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STIM1
		8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate STIM1 (see all 50):
		hsa-miR-15a hsa-miR-218-1* hsa-let-7a-2* hsa-miR-486-3p hsa-miR-223 hsa-miR-1184 hsa-miR-424 hsa-miR-155*

		SwitchGear 3'UTR luciferase reporter plasmid: STIM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STIM1 (see all 7) OriGene shRNA RFP: STIM1 OriGene siRNA: STIM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STIM1
		Sirion Biotech Custom design and validation of potent shRNA sequences against STIM1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for STIM1
			Sirion Biotech Customized adenovirus for overexpression of STIM1 Sirion Biotech Customized adenovirus for potent knockdown of STIM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STIM1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STIM1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STIM1 (NM_003156)
		Sino Biological Human cDNA Clone for STIM1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STIM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIM1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STIM1
		Search LifeMap BioReagents cell lines for STIM1
		Sirion Biotech Customized stable knockdown cell line services for STIM1 Sirion Biotech Customized inducible knockdown cell line services for STIM1 Sirion Biotech Customized stable overexpressing cell line services for STIM1 Sirion Biotech Customized inducible overexpressing cell line services for STIM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIM1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet calcium homeostasis

Platelet calcium homeostasis

1.00

Elevation of cytosolic Ca2+ levels

0.47

TCR signaling in naive CD4+ T cells

TCR signaling in naive CD4+ T cells

1.00

TCR signaling in naive CD8+ T cells

0.64

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for STIM1

Ca, cAMP and Lipid Signaling

2 BioSystems Pathways for STIM1

	TCR signaling in naive CD8+ T cells
	TCR signaling in naive CD4+ T cells

5/8 Reactome Pathways for STIM1 (see all 8)

	Hemostasis
	Platelet homeostasis
	Adaptive Immune System
	Elevation of cytosolic Ca2+ levels
	Signaling by the B Cell Receptor (BCR)

STIM1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STIM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/19 Interacting proteins for STIM1 (Q13586^{1, 2, 3} ENSP00000300737⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ORAI1	Q96D31¹^,²^,³, ENSP00000328216⁴	EBI-448878,EBI-2291476 MINT-8186918 I2D: score=2 STRING: ENSP00000328216
STIM2	Q9P246¹^,³, ENSP00000404812⁴	EBI-448878,EBI-448891 I2D: score=2 STRING: ENSP00000404812
STIM1	Q13586¹^,²	EBI-448878,EBI-448878 MINT-8186937
PDIA3	P30101²	MINT-8303523 MINT-8303574 MINT-8303549
MAPRE1	Q15691³, ENSP00000364721⁴	I2D: score=1 STRING: ENSP00000364721

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005513	detection of calcium ion	IDA	16005298
GO:0006812	cation transport	--	--
GO:0006816	calcium ion transport	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0032237	activation of store-operated calcium channel activity	IDA	16005298

STIM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

STIM1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for STIM1 available from Tocris Bioscience About this table

Compound	Action	CAS #
2-APB	IP3 receptor antagonist. Also TRP channel modulator	[524-95-8]
SKF 96365 hydrochloride	STIM1-mediated Ca2+ influx inhibitor	[130495-35-1]
ML 9 hydrochloride	Myosin light chain kinase inhibitor	[105637-50-1]

1 HMDB Compound for STIM1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 Novoseek chemical compound relationship for STIM1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	40.1	35	19433064 (6), 19765994 (5), 17158173 (4), 17283081 (4) (see all 6)

Search CenterWatch for drugs/clinical trials and news about STIM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STIM1 gene:

NM_003156.3

Unigene Cluster for STIM1:

Stromal interaction molecule 1

Hs.501735 [show with all ESTs]

Unigene Representative Sequence: AK098480

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000525403 ENST00000300737(uc001lyv.2 uc009yef.2 uc021qco.1 uc009yeg.2)

ENST00000527651 ENST00000532610 ENST00000532919 ENST00000530554 ENST00000524822

ENST00000525055 ENST00000528656 ENST00000532990 ENST00000526771 ENST00000527484

ENST00000533445 ENST00000533977 ENST00000526596 ENST00000533343 ENST00000531332

ENST00000526156

miRNA Products:		OriGene 3'-UTR Clone: STIM1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STIM1
		8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate STIM1 (see all 50):
		hsa-miR-15a hsa-miR-218-1* hsa-let-7a-2* hsa-miR-486-3p hsa-miR-223 hsa-miR-1184 hsa-miR-424 hsa-miR-155*

		SwitchGear 3'UTR luciferase reporter plasmid: STIM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STIM1 (see all 7) OriGene shRNA RFP: STIM1 OriGene siRNA: STIM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STIM1
		Sirion Biotech Custom design and validation of potent shRNA sequences against STIM1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STIM1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STIM1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STIM1 (NM_003156)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STIM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STIM1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STIM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STIM1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STIM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STIM1

Additional cDNA sequence:

AK098480.1 AK310510.1 AK314928.1 BC021300.2 HQ317451.1 U52426.1

14 DOTS entries:

DT.452685 DT.95348658 DT.100778602 DT.91659921 DT.100027863 DT.120700283 DT.100771298 DT.95093752

DT.97825540 DT.100692013 DT.120700357 DT.91698159 DT.100000386 DT.120700268

24/232 AceView cDNA sequences (see all 232):

AA962482 AA911624 AA625594 BQ224617 AI620105 AI935048 CK906236 AL041188

AI383417 BQ022907 CF243011 AA777220 CD358069 BI024710 BM823714 CA389521

AI431613 AA157018 BQ222013 CK000574 CA450183 BE858124 BG152905 BQ961786

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STIM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGAGATTT

About this image

STIM1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STIM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STIM1

SOURCE GeneReport for Unigene cluster: Hs.501735

UniProtKB/Swiss-Prot: STIM1_HUMAN, Q13586

Tissue specificity: Ubiquitously expressed in various human primary cells and tumor cell lines

SABiosciences Custom PCR Arrays for STIM1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STIM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STIM1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STIM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STIM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STIM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STIM1 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STIM1¹	stromal interaction molecule 1	77.39(n) 80.43(a)		419082 NM_001030838.1 NP_001026009.1
lizard (Anolis carolinensis)	Reptilia	STIM1⁶	--	80(a)	1 ↔ 1	GL343693.1(58784-99341)
African clawed frog (Xenopus laevis)	Amphibia	BU899888.1²	--	78.96(n)		BU899888.1
zebrafish (Danio rerio)	Actinopterygii	CD605508.1²	--	80.64(n)		CD605508.1
fruit fly (Drosophila melanogaster)	Insecta	Stim^{1 , 3}	cell adhesion³ Stromal interaction molecule¹	41(a)³ 51.76(n)¹ 43.35(a)¹		32556¹ NM_078633.3¹ NP_523357.2¹
worm (Caenorhabditis elegans)	Secernentea	stim-1¹	Protein STIM-1	43.7(n) 33.83(a)		175201 NM_171065.3 NP_741073.1

ENSEMBL Gene Tree for STIM1 (if available)
TreeFam Gene Tree for STIM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STIM1 gene

STIM2²

1 SIMAP similar gene for STIM1 using alignment to 13 protein entries: STIM1_HUMAN (see all proteins):

STIM2

STIM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112807206^1,2		--	3609181(+)	`AGGTGG/ACTGAG`	1	--	us2k¹		2		CSA WA	120
rs113332475^1,2		--	3609592(+)	`GTAGCT/AGGGAG`	1	--	us2k¹		1		CSA	2
rs3887707^1,2	A,H	--	3609739(+)	`GGGTCG/TGGAAA`	1	--	us2k¹		4		NS EA	414
rs28362516^1,2		--	3610126(+)	`GGCCGA/GGCCGG`	1	--	us2k¹		2		MN EA	1252
rs61899393^1,2	C,F	--	3610159(+)	`CAGCTC/TCTGGG`	1	--	us2k¹		3		NA	124
rs117982546^1,2	C	--	3611129(+)	`GGGCTC/TCTGGC`	1	--	ut5¹		2		NA EU	705
rs201794614^1,2	C	--	3611187(+)	`AGACCG/TAGAGT`	1	--	ut5¹		0	--	--	--	--
rs139540641^1,2	C	--	3611298(+)	`ACCAGC/TTCGGG`	2	S	syn¹		1		NA	4552
rs150033189^1,2	C,F	--	3611307(+)	`GGGGCC/GAACTC`	2	A	syn¹		2		NA EU	5873
rs199693618^1,2	C,F	--	3611360(+)	`ACTGGG/ACTGGA`	1	--	int¹		1		EU	1063

HapMap Linkage Disequilibrium report for STIM1 (3875757 - 4114440 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STIM1
2 CNVs: 3834 101111
1 Indel: 44887
Human Gene Mutation Database (HGMD): STIM1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STIM1

DNA2.0 Custom Variant and Variant Library Synthesis for STIM1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STIM1 for disorders           About GeneDecksing

OMIM gene information: 605921
OMIM disorders: 612783
UniProtKB/Swiss-Prot: STIM1_HUMAN, Q13586

Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type

2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell

activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal

lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic

anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition

20/28 diseases for STIM1 (see all 28): About MalaCards

immune dysfunction with t-cell inactivation due to calcium entry defect 2 lambert-eaton myasthenic syndrome beckwith-wiedemann syndrome rhabdomyosarcoma

classic kaposi sarcoma iris hypoplasia type 2 diabetes mellitus autoimmune hemolytic anemia

hemolytic anemia wilms tumor rhabdoid tumors kaposi's sarcoma

breast cancer diabetes mellitus myasthenic syndrome fibrosarcoma

hematopoiesis breast fibrosarcoma carcinoma anemia

3 Novoseek disease relationships for STIM1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdoid tumor	65.6	9	9377559 (5), 10575208 (1)
rhabdomyosarcoma	54.6	13	9377559 (7), 10575208 (1), 11004585 (1)
tumors	0	16	10575208 (3), 9377559 (2)

Genetic Association Database (GAD): STIM1
Human Genome Epidemiology (HuGE) Navigator: STIM1 (1 document)

Export disorders for STIM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STIM1 gene, integrated from 9 sources (see all 174):
(articles sorted by number of sources associating them with STIM1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5. (PubMed id 8921403)^{1, 2, 3, 9} Parker N.J.... Fox R.M. (1996)
Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation. (PubMed id 11983428)^{1, 2, 3} Williams R.T....Dziadek M.A. (2002)
Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. (PubMed id 11463338)^{1, 2, 3} Williams R.T.... Dziadek M.A. (2001)
GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. (PubMed id 9377559)^{1, 2, 9} Sabbioni S.... Negrini M. (1997)
STIM1: a novel phosphoprotein located at the cell surface. (PubMed id 11004585)^{1, 2, 9} Manji S.S.... Smith P.J. (2000)
Orai1 and STIM reconstitute store-operated calcium channel function. (PubMed id 16766533)^{1, 2, 9} Soboloff J....Gill D.L. (2006)
Junctate is a Ca2+-sensing structural component of Ora i1 and stromal interaction molecule 1 (STIM1). (PubMed id 22586105)^{1, 2} Srikanth S....Gwack Y. (2012)
Structural and mechanistic insights into the activatio n of Stromal interaction molecule 1 (STIM1). (PubMed id 22451904)^{1, 2} Yang X....Shen Y. (2012)
STIM1 mutation associated with a syndrome of immunode ficiency and autoimmunity. (PubMed id 19420366)^{1, 2} Picard C....Feske S. (2009)
An EB1-binding motif acts as a microtubule tip locali zation signal. (PubMed id 19632184)^{1, 2} Honnappa S....Steinmetz M.O. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6786	HGNC: 11386	AceView: STIM1	Ensembl:ENSG00000167323	euGenes: HUgn6786
ECgene: STIM1	H-InvDB: STIM1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STIM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for STIM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for STIM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STIM1 gene:
Search GeneIP for patents involving STIM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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stromal interaction molecule 1

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