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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STIL Gene

protein-coding   GIFtS: 53
GCID: GC01M047715

SCL/TAL1 interrupting locus

(Previous name: TAL1 (SCL) interrupting locus )
(Previous symbol: SIL)
 Explore 15 diseases affiliated with
STIL via
MalaCards
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 Human Malady Compendium 
Biological research products
for STIL    

Aliases
for STIL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SCL/TAL1 Interrupting Locus1 2
SIL1 2 3 5
MCPH71 2 5
TAL-1-Interrupting Locus Protein2 3
TAL1 (SCL) Interrupting Locus1
SCL-Interrupting Locus Protein2

External Ids:    HGNC: 108791   Entrez Gene: 64912   Ensembl: ENSG000001234737   OMIM: 1815905   UniProtKB: Q154683   

Export aliases for STIL gene to outside databases

Previous GC identifers: GC01M047428 GC01M047488 GC01M045832


Summaries
for STIL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STIL:
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory
pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to
daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and
disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to
efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint
arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are
thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STIL_HUMAN, Q15468
Function: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and
proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1
activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog
pathway, acting downstream of PTCH1

Gene Wiki entry for STIL


Genomic Views
for STIL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STIL gene promoter:
         GR   Bach1   Pax-5   LCR-F1   Gfi-1   c-Rel   IRF-2   FOXC1   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STIL promoter sequence
   Search SABiosciences Chromatin IP Primers for STIL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STIL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p32

STIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STIL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047715:  view genomic region     (about GC identifiers)

Start:
 47,715,811 bp from pter      End:
 47,779,819 bp from pter
Size:
 64,009 bases      Orientation:
 minus strand

Proteins
for STIL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STIL_HUMAN, Q15468 (See protein sequence)
Recommended Name: SCL-interrupting locus protein  
Size: 1287 amino acids; 142955 Da
Subunit: Interacts with PIN1 via its WW domain. This interaction is dependent on STIL mitotic phosphorylation (By
similarity)
Subcellular location: Cytoplasm, cytosol (By similarity)
Secondary accessions: Q5T0C5 Q68CN9
Alternative splicing: 2 isoforms:  Q15468-1   Q15468-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STIL: NX_Q15468

Post-translational modifications:

  • Phosphorylated following the activation of the mitotic checkpoint1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15468

    • STIL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001041631.1  NP_003026.2  

    ENSEMBL proteins: 
     ENSP00000353544   ENSP00000360944   ENSP00000379523   ENSP00000411664   ENSP00000409087  
     ENSP00000412019   ENSP00000337367   ENSP00000243182  

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    Uscn Proteins for STIL

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005829cytosol IEA--


    STIL for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for STIL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STIL for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026123 Sil

    Graphical View of Domain Structure for InterPro Entry Q15468

    ProtoNet protein and cluster: Q15468


    Function
    for STIL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STIL_HUMAN, Q15468
    Function: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and
    proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1
    activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog
    pathway, acting downstream of PTCH1
    Induction: Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the
    cell cycle

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    hsa-miR-3163 hsa-miR-144 hsa-miR-1266 hsa-miR-4305 hsa-miR-4276 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: STIL 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Animal Models:
         Mouse knock-out Stiltm1Mku for STIL
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Stil):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 

    STIL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STIL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling events mediated by the Hedgehog family
    		Signaling events mediated by the Hedgehog family1.00


    1 BioSystems Pathway for STIL 
        Signaling events mediated by the Hedgehog family


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STIL

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for STIL (Q154682, 3 ENSP000003609444) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPJQ9HC772MINT-8389200 MINT-8389100 MINT-8389119 MINT-8388987 MINT-8389061 MINT-8389076 MINT-8389227 MINT-8389213 MINT-8389143 MINT-8389045 MINT-8389027 MINT-8389177 MINT-8389160
    SASS6Q6UVJ02MINT-8389200 MINT-8389015 MINT-8389213 MINT-8389027 MINT-8389227
    PIN1Q135263, ENSP000002479704I2D: score=2 STRING: ENSP00000247970
    STILQ154682MINT-8389003
    PTCH1ENSP000003323534STRING: ENSP00000332353
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000578embryonic axis specification ISS--
    GO:0001701in utero embryonic development ISS--
    GO:0001843neural tube closure ISS--
    GO:0001947heart looping ISS--
    GO:0007224smoothened signaling pathway ISS--


    STIL for ontologies           About GeneDecksing



    Drugs & Compounds
    for STIL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STIL
    Search CenterWatch for drugs/clinical trials and news about STIL 

    Transcripts
    for STIL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STIL gene (2 alternative transcripts): 
    NM_001048166.1  NM_003035.2  

    Unigene Cluster for STIL:

    SCL/TAL1 interrupting locus
    Hs.525198  [show with all ESTs]
    Unigene Representative Sequence: M74558
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360380(uc010omn.1 uc010omo.1 uc001cre.1 uc001crg.1)
    ENST00000371877 ENST00000396221 ENST00000447475 ENST00000418131(uc001crf.1)
    ENST00000436811 ENST00000433827 ENST00000413565 ENST00000337817(uc001crc.1 uc001crd.1)
    ENST00000243182

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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate STIL:
    hsa-miR-3163 hsa-miR-144 hsa-miR-1266 hsa-miR-4305 hsa-miR-4276 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: STIL 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): STIL (NM_003035)
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    Additional cDNA sequence: 

    AK098445.1 AK307519.1 BC053615.1 BC126223.1 BC136432.1 BC144089.1 CR749851.1 M74558.1 

    6 DOTS entries:

    DT.95373288  DT.95373289  DT.101979403  DT.101979402  DT.102823755  DT.75121460 

    24/70 AceView cDNA sequences (see all 70):

    AI720064 BQ437963 BX279974 BE889805 AI800146 BM474113 BC053615 BU153990 
    AW079492 BM801838 AA903387 AI263718 BU181351 BQ438813 AU118011 BX462076 
    AK098445 AW175880 BM759867 NM_003035 AI276535 AI870176 AA897748 BE886166 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for STIL (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^
    SP1:                                                                                -                                                     -                     
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                                                                            

    ExUns: 21
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for STIL

    Expression
    for STIL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STIL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACACTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STIL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STIL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STIL

    SOURCE GeneReport for Unigene cluster: Hs.525198

    UniProtKB/Swiss-Prot: STIL_HUMAN, Q15468
    Tissue specificity: Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors
    characterized by increased mitotic activity with highest expression in lung cancer

        SABiosciences Expression via Pathway-Focused PCR Array including STIL: 
              Notch Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for STIL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for STIL gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stil1 , 5 Scl/Tal1 interrupting locus1, 5 81.4(n)1
    75.28(a)1    		   4 (52.73 cM)5
    204601  NM_009185.31  NP_033211.21 
     1150001595 
    chicken
    (Gallus gallus)    		 Aves STIL1 SCL/TAL1 interrupting locus 63.78(n)
    54.57(a)    		   424621  XM_422457.3  XP_422457.2 
    lizard
    (Anolis carolinensis)    		 Reptilia STIL6
    		 --
    		 49(a)
    		 1 ↔ 1
    		 GL343249.1(1673355-1689611)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.70382 Xenopus laevis transcribed sequence with weak similarity more 75.55(n)    CA790785.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sill2 TAL1 (SCL) interrupting locus like 74.08(n)   192317  AY099525.1 


    ENSEMBL Gene Tree for STIL (if available)
    TreeFam Gene Tree for STIL (if available) 

    Paralogs
    for STIL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for STIL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1234 NCBI SNPs in STIL are shown (see all 1234)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs31256301,2
    		C,F,O,A,H,non-pathogenic47767914(+) CGTCTA/GCTGTC 4 A V mis1 ese337Minor allele frequency- G:0.39NS EA NA WA CSA EU 8857
    rs284725451,2
    		Cnon-pathogenic52041814(+) ATGGTG/TGGATC 4 Q P mis10--------
    rs287053681,2
    		Cnon-pathogenic52041815(+) GATGGG/TTGGAT 4 Q H mis10--------
    rs37663171,2
    		C,F,H,non-pathogenic52071464(-) CAATGC/TAGATA 4 A V mis1 ese39Minor allele frequency- T:0.01EA NS NA 2250
    rs1219186091,2
    		Cpathogenic52071745(-) TCACTC/TAACAT 4 Q * stg10--------
    rs1118954901,2
    		--45832030(+) GGAGAC/TAGAAG 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs776635571,2
    		C,--45832138(+) ATATAC/TCAAAA 2 -- ds50013Minor allele frequency- T:0.45WA CSA 121
    rs347718411,2
    		C--45832613(+) TGTATAA/-AAGAG 4 -- ut311Minor allele frequency- -:0.50NA 2
    rs112114871,2
    		--45832803(+) tcacgC/Tctgta 2 -- ut31 ese33Minor allele frequency- T:0.20NA CSA 5
    rs112114881,2
    		C,--45833064(+) tctcaG/Aaaaaa 2 -- ut31 trp33Minor allele frequency- A:0.47WA CSA 121

    HapMap Linkage Disequilibrium report for STIL (47715811 - 47779819 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for STIL
         2 CNVs: 37649 6825
    Human Gene Mutation Database (HGMD): STIL

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    Disorders / Diseases
    for STIL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STIL for disorders           About GeneDecksing

    OMIM gene information: 181590   
    OMIM disorders: 612703  
    UniProtKB/Swiss-Prot: STIL_HUMAN, Q15468
  • Note=A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias
    • (T-ALL). A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to
    TAL1 exon 3. As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full
    length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. In childhood
    T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. In
    cultured lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be detected after 7 days of culture
  • Defects in STIL are the cause of microcephaly primary type 7 (MCPH7) [MIM:612703]. Microcephaly is defined as
    • a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and
    the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is
    relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined
    by the absence of other syndromic features or significant neurological deficits

    15 diseases for STIL:    About MalaCards
    leukemia    primary autosomal recessive microcephaly    t-cell leukemia    leukemoid reaction
    congenital syphilis    microcephaly    acute lymphoblastic leukemia    lymphoblastic leukemia
    syphilis    leukemia/lymphoma    holoprosencephaly    lymphocytic leukemia
    pancreatic cancer    lung cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for STIL:
    Microcephaly

    5 Novoseek disease relationships for STIL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 88 31 8459224 (5), 18439091 (4), 8255100 (3), 7773964 (1) (see all 8)
    leukemogenesis 64.3 1 16368887 (1)
    minimal residual disease 50.3 1 8255100 (1)
    acute leukemia 36.9 2 8255100 (1)
    leukemia 23.1 2 8255100 (1)

    GeneTests: STIL
    Primary Autosomal Recessive Microcephaly

    Human Genome Epidemiology (HuGE) Navigator: STIL (3 documents)

    Export disorders for STIL gene to outside databases

    Publications
    for STIL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STIL gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with STIL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. (PubMed id 2209547)1, 2, 3 Brown L....Baer R. (1990)
    2. Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR. (PubMed id 12681356)1, 2, 9 Curry J.D. and Smith M.T. (2003)
    3. Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly. (PubMed id 19215732)1, 2 Kumar A.... Blanton S.H. (2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. (PubMed id 16024801)1, 2 Campaner S.... Kirsch I.R. (2005)
    6. Sil overexpression in lung cancer characterizes tumors with increased mitotic activity. (PubMed id 15107824)1, 2 Erez A.... Izraeli S. (2004)
    7. Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. (PubMed id 14504110)1, 2 Cave H.... Dastugue N. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly. (PubMed id 12438740)1, 2 Karkera J.D....Muenke M. (2002)
    10. Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints. (PubMed id 11390401)1, 2 Raghavan S.C.... Lieber M.R. (2001)

    External Searches for STIL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing STIL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6491 HGNC: 10879 AceView: SIL Ensembl:ENSG00000123473 euGenes: HUgn6491
    ECgene: STIL H-InvDB: STIL

    Other Databases showing STIL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STIL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STIL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STIL Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for STIL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STIL gene:
    Search GeneIP for patents involving STIL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     Regulatory tfbs in STIL promoter
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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