STH Gene
protein-coding GIFtS: 38
GCID: GC17P044076
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saitohin
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Aliases
for STH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Saitohin1 | | MAPTIT1 2 | | Microtubule-Associated Protein Tau (MAPT) Intronic Transcript2 |
Export aliases for STH gene to outside databasesPrevious GC identifers: GC17U990336 GC17P041432 |
Summaries
for STH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for STH
|
Genomic Views
for STH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15 NT_167251.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STH gene promoter:
SRF HOXA9 SRF (504 AA) Meis-1b NF-AT NF-AT4 NF-AT2 NF-AT3 Pax-4a NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.1STH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P044076: view genomic region
(about GC identifiers)
Start:
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44,076,616 bp from pter |
End:
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44,077,060 bp from pter |
Size:
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445 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17-,ALT_REF_LOCI_9 44,099,522-44,099,966 |
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Proteins
for STH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STH_HUMAN, Q8IWL8 (See
protein sequence)Recommended Name: Saitohin Size: 128 amino acids; 13652 Da
Subunit: Interacts with PRDX6
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Was called 'saitohin' in honor of the late Tsuanao Saitoh and his laboratory
Secondary accessions: A1L3X7Explore the universe of human proteins at neXtProt for STH: NX_Q8IWL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWL8
STH Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001007533.1
ENSEMBL proteins: ENSP00000443168
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
STH for ontologies About GeneDecksing
STH Antibody Products:
Assay Products for STH: |
Protein
Domains /
Families
for STH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IWL8 |
Function
for STH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STH
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STH (NM_001007532) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STH |
|
Pathways & Interactions
for STH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STH
|
Drugs & Compounds
for STH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STH
Search CenterWatch for drugs/clinical trials and news about STH
|
Transcripts
for STH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STH gene: NM_001007532.2 Unigene Cluster for STH: Saitohin Hs.661831 Unigene Representative Sequence: NM_0010075321 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000537309(uc002ijy.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STH
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STH (NM_001007532) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STH |
Additional cDNA sequence: AY179170.1 BC130319.1 BC130321.1 1 DOTS entry: DT.40215379
GeneLoc Exon Structure
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Expression
for STH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAGTGTAG
About this image
Genevestigator expression for STH
SOURCE GeneReport for Unigene cluster: Hs.661831
UniProtKB/Swiss-Prot: STH_HUMAN, Q8IWL8Tissue specificity: Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression inheart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporallobe, hypothalamus, medulla and spinal cord, with lower expression in other brain regions
SABiosciences Custom PCR Arrays for STH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STH |
Orthologs
for STH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for STH (if available)
TreeFam Gene Tree for STH (if available) |
Paralogs
for STH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for STH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: STH_HUMAN, Q8IWL8Polymorphism: The Arg-7 polymorphism may be associated with progressive supranuclear palsy
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for STH
3 CNVs: 2225 8850 8851
1 Inversion: 37194
Human Gene Mutation Database (HGMD): STH
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for STH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STH for disorders About GeneDecksing
OMIM gene information: 607067
OMIM disorders: --
8  diseases for STH: About MalaCardssupranuclear palsy progressive supranuclear palsy frontotemporal dementia tauopathy
neurodegenerative disease dementia parkinson's disease alzheimer's disease
6 Novoseek disease relationships for STH gene About this table
Genetic Association Database (GAD): STH
Human Genome Epidemiology (HuGE) Navigator: STH (110 documents)
Export disorders for STH gene to outside databases
|
Publications
for STH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STH gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with STH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6. (PubMed id 16186110)1, 2, 3 Gao L....Andreadis A. (2005)
- Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy. (PubMed id 12913211)1, 2, 4 de Silva R....Lees A.J. (2003)
- A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease. (PubMed id 12032355)1, 2, 3 Conrad C.... Davies P. (2002)
- Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism. (PubMed id 15136700)1, 4 Seripa D....Fazio V.M. (2004)
- No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease. (PubMed id 12402275)1, 2 Cook L....Rubinsztein D.C. (2002)
- Variation at APOE and STH loci and Alzheimer's disease. (PubMed id 16603077)1, 9 Zuo L....Gelernter J. (2006)
- HD phenocopies--possible role of Saitohin gene. (PubMed id 18300012)1, 9 Jankovic N....Romac S. (2008)
- TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease. (PubMed id 16909000)1, 9 Johansson A....Blennow K. (2005)
- Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia. (PubMed id 12826737)1, 9 Zekanowski C....Barcikowska M. (2003)
- Strong association between Saitohin gene polymorphism and tau haplotype in the Polish population. (PubMed id 12932819)1, 9 Pepl/onska B....Kuznicki J. (2003)
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External Searches for STH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing STH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STH | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for STH gene:
Search GeneIP for patents involving STH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STH | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STH | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STH | | OriGene Custom Protein Services for STH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STH | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STH |
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 | | | STH Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for STH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STH |
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