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Aliases for STH Gene

Aliases for STH Gene

  • Saitohin 2 3
  • Microtubule-Associated Protein Tau (MAPT) Intronic Transcript 2 3
  • MAPTIT 3

External Ids for STH Gene

Summaries for STH Gene

GeneCards Summary for STH Gene

STH (Saitohin) is a Protein Coding gene. Diseases associated with STH include argyrophilic grain disease and alzheimer disease.

Gene Wiki entry for STH Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STH Gene

Genomics for STH Gene

Genomic Location for STH Gene

Start:
45,999,250 bp from pter
End:
45,999,694 bp from pter
Size:
445 bases
Orientation:
Plus strand

Genomic View for STH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STH Gene

Regulatory Elements for STH Gene

Proteins for STH Gene

  • Protein details for STH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWL8-STH_HUMAN
    Recommended name:
    Saitohin
    Protein Accession:
    Q8IWL8
    Secondary Accessions:
    • A1L3X7

    Protein attributes for STH Gene

    Size:
    128 amino acids
    Molecular mass:
    13652 Da
    Quaternary structure:
    • Interacts with PRDX6.
    Miscellaneous:
    • Was called saitohin in honor of the late Tsuanao Saitoh and his laboratory

neXtProt entry for STH Gene

Proteomics data for STH Gene at MOPED

Post-translational modifications for STH Gene

No Post-translational modifications

Other Protein References for STH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STH Gene

Domains for STH Gene

Protein Domains for STH Gene

ProtoNet:

Suggested Antigen Peptide Sequences for STH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STH: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STH Gene

Function for STH Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STH Gene

Localization for STH Gene

Subcellular locations from UniProtKB/Swiss-Prot for STH Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for STH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with STH: view

No data available for Subcellular locations from COMPARTMENTS for STH Gene

Pathways for STH Gene

SuperPathways for STH Gene

No Data Available

Interacting Proteins for STH Gene

Gene Ontology (GO) - Biological Process for STH Gene

None

No data available for Pathways by source for STH Gene

Transcripts for STH Gene

mRNA/cDNA for STH Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STH Gene

Saitohin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STH Gene

No ASD Table

Relevant External Links for STH Gene

GeneLoc Exon Structure for
STH
ECgene alternative splicing isoforms for
STH

Expression for STH Gene

mRNA expression in normal human tissues for STH Gene

mRNA differential expression in normal tissues according to GTEx for STH Gene

This gene is overexpressed in Brain - Cerebellum (8.3) and Brain - Cerebellar Hemisphere (8.2).

SOURCE GeneReport for Unigene cluster for STH Gene Hs.661831

mRNA Expression by UniProt/SwissProt for STH Gene

Q8IWL8-STH_HUMAN
Tissue specificity: Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression in heart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporal lobe, hypothalamus, medulla and spinal cord, with lower expression in other brain regions.
genes like me logo Genes that share expressions with STH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for STH Gene

Orthologs for STH Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for STH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STH 35
  • 98.7 (n)
  • 97.66 (a)
Species with no ortholog for STH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STH Gene

ENSEMBL:
Gene Tree for STH (if available)
TreeFam:
Gene Tree for STH (if available)

Paralogs for STH Gene

No data available for Paralogs for STH Gene

Variants for STH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for STH Gene

Q8IWL8-STH_HUMAN
The Arg-7 polymorphism may be associated with progressive supranuclear palsy

Sequence variations from dbSNP and Humsavar for STH Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_019548 -

Structural Variations from Database of Genomic Variants (DGV) for STH Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV Gain 17911159
nsv510714 CNV Loss 20534489
esv2751686 CNV Gain 17911159
nsv469705 CNV Loss 16826518
nsv2068 CNV Insertion 18451855

Relevant External Links for STH Gene

HapMap Linkage Disequilibrium report
STH
Human Gene Mutation Database (HGMD)
STH

Disorders for STH Gene

(6) Novoseek inferred disease relationships for STH Gene

Disease -log(P) Hits PubMed IDs
frontotemporal dementia 66.6 1
tauopathies 62.6 1
neurodegenerative diseases 60.9 2
alzheimers disease 58.9 7
parkinson disease 44.4 2

Relevant External Links for STH

Genetic Association Database (GAD)
STH
Human Genome Epidemiology (HuGE) Navigator
STH
genes like me logo Genes that share disorders with STH: view

No data available for UniProtKB/Swiss-Prot for STH Gene

Publications for STH Gene

  1. Variation at APOE and STH loci and Alzheimer's disease. (PMID: 16603077) Zuo L. … Gelernter J. (Behav Brain Funct 2006) 3 23 48
  2. TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease. (PMID: 16909000) Johansson A. … Blennow K. (Neurodegener Dis 2005) 3 23 48
  3. HD phenocopies--possible role of Saitohin gene. (PMID: 18300012) JankoviA8 N. … Romac S. (Int. J. Neurosci. 2008) 3 23 48
  4. Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease. (PMID: 18396294) Wang B. … Ma X. (J. Neurol. Sci. 2008) 3 23 48
  5. Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study. (PMID: 18509094) Tobin J.E. … Myers R.H. (Neurology 2008) 3 23 48

Products for STH Gene

Sources for STH Gene

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