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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STEAP4 Gene

protein-coding   GIFtS: 53
GCID: GC07M087905

STEAP family member 4

(Previous names: tumor necrosis factor, alpha-induced protein 9 )
(Previous symbol: TNFAIP9)
 Explore 9 diseases affiliated with
STEAP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STEAP4    

Aliases
for STEAP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
STEAP Family Member 41 2     FLJ231531
STAMP21 2 3 5     Metalloreductase STEAP42
Tumor Necrosis Factor, Alpha-Induced Protein 91 2 3     Six Transmembrane Prostate Protein 22
TNFAIP91 2 3     Tumor Necrosis-Alpha-Induced Adipose-Related Protein2
TIARP1 2 5     EC 1.16.1.-3
Six-Transmembrane Epithelial Antigen Of Prostate 42 3     EC 1.16.18
SixTransMembrane Protein Of Prostate 22 3     

External Ids:    HGNC: 219231   Entrez Gene: 796892   Ensembl: ENSG000001279547   OMIM: 6110985   UniProtKB: Q687X53   

Export aliases for STEAP4 gene to outside databases

Previous GC identifers: GC07M087552 GC07M087745 GC07M087900 GC07M082517


Summaries
for STEAP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STEAP4:
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and
resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to
Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved
in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as
prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: STEA4_HUMAN, Q687X5
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as
acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By
similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the
regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation




Genomic Views
for STEAP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STEAP4 gene promoter:
         Lmo2   HNF-4alpha2   RelA   HNF-3beta   HNF-4alpha1   RORalpha2   SRY   Cart-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STEAP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for STEAP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.12   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.13

STEAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M087905:  view genomic region     (about GC identifiers)

Start:
 87,905,744 bp from pter      End:
 87,936,209 bp from pter
Size:
 30,466 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 87,237,102-87,267,568     

Proteins
for STEAP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STEA4_HUMAN, Q687X5 (See protein sequence)
Recommended Name: Metalloreductase STEAP4  
Size: 459 amino acids; 51981 Da
Cofactor: FAD (By similarity)
Subunit: Interacts with and phosphorylates PTK2/FAK1
Subcellular location: Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAQ04064.1; Type=Frameshift; Positions=384; Sequence=BAB15559.1; Type=Frameshift;
Positions=252, 364; Sequence=CAH56271.1; Type=Erroneous initiation;
Secondary accessions: Q658Q9 Q687X4 Q8WWB0 Q9H5R1
Alternative splicing: 2 isoforms:  Q687X5-1   Q687X5-2   

Explore the universe of human proteins at neXtProt for STEAP4: NX_Q687X5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q687X5

    • 3 DME Specific Peptides for STEAP4 (Q687X5)
     GTKYRRFP  RFPDWLDHW  NQYPESNAEYLA 

    STEAP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001192244.1  NP_001192245.1  NP_078912.2  

    ENSEMBL proteins: 
     ENSP00000369419   ENSP00000305545   ENSP00000394399  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: STEAP4
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    Novus Biologicals STEAP4 Protein
    Novus Biologicals STEAP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STEAP4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005886plasma membrane ISS--
    GO:0016021integral to membrane IEA--


    STEAP4 for ontologies           About GeneDecksing



    STEAP4 Antibody Products: 
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    Novus Biologicals STEAP4 Antibodies
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    Uscn Antibodies for STEAP4
    ThermoFisher Antibodies for STEAP4

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    Uscn ELISAs and CLIAs for STEAP4

    Protein Domains /
    Families
    for STEAP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STEAP4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004455 NADP_OxRdtase_F420
     IPR013130 Fe3_Rdtase_TM_dom
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q687X5

    ProtoNet protein and cluster: Q687X5

    UniProtKB/Swiss-Prot: STEA4_HUMAN, Q687X5
    Similarity: Belongs to the STEAP family
    Similarity: Contains 1 ferric oxidoreductase domain


    Function
    for STEAP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STEA4_HUMAN, Q687X5
    Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as
    acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By
    similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the
    regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation
    Induction: By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and
    dihydrotestosterone (DHT)

    Enzyme Numbers (IUBMB): EC 1.16.1.-1 EC 1.16.12

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP4
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP4 (see all 26):
    hsa-miR-513c hsa-miR-507 hsa-miR-371-5p hsa-miR-29b-1* hsa-miR-373* hsa-miR-3916 hsa-miR-3125 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: STEAP4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STEAP4 (see all 7)
    OriGene shRNA RFP: STEAP4
    OriGene siRNA: STEAP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STEAP4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP4 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): STEAP4 (NM_024636)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP4 

    Cell Line
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    Search LifeMap BioReagents cell lines for STEAP4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--


    STEAP4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STEAP4:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Steap4tm1Dgen for STEAP4
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Steap4):
     adipose tissue  behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  muscle 

    STEAP4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STEAP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STEAP4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for STEAP4 (ENSP000003694194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    AKT2ENSP000003758924STRING: ENSP00000375892
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0045444fat cell differentiation ISS--
    GO:0055072iron ion homeostasis IEA--


    STEAP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STEAP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STEAP4

    3 HMDB Compounds for STEAP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Search CenterWatch for drugs/clinical trials and news about STEAP4 / STEA4 

    Transcripts
    for STEAP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STEAP4 gene (3 alternative transcripts): 
    NM_001205315.1  NM_001205316.1  NM_024636.3  

    Unigene Cluster for STEAP4:

    STEAP family member 4
    Hs.521008  [show with all ESTs]
    Unigene Representative Sequence: NM_001205315
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380079(uc022agz.1 uc003ujs.3 uc010lek.3) ENST00000301959
    ENST00000414498

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP4
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP4 (see all 26):
    hsa-miR-513c hsa-miR-507 hsa-miR-371-5p hsa-miR-29b-1* hsa-miR-373* hsa-miR-3916 hsa-miR-3125 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: STEAP4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STEAP4 (see all 7)
    OriGene shRNA RFP: STEAP4
    OriGene siRNA: STEAP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP4
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): STEAP4 (NM_024636)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STEAP4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STEAP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP4

    Additional cDNA sequence: 

    AF423422.1 AF423423.1 AK026806.1 AK027807.1 AK307644.1 AL832955.1 AL833044.1 AL833671.1 
    BC020600.1 

    5 DOTS entries:

    DT.100891155  DT.100022712  DT.75200164  DT.95369132  DT.100891151 

    24/121 AceView cDNA sequences (see all 121):

    AA923172 CR601647 AI376083 BC020600 AA661766 AI650291 R81150 AL833671 
    AI373568 AA442372 CA397404 AI806044 AF423422 AF423423 CA438520 AI139607 
    H04283 BU685836 AL833044 AI089592 BM978383 BQ941620 BF197854 AA418803 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STEAP4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:              -                                       
    SP2:              -           -     -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for STEAP4

    Expression
    for STEAP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STEAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAGGGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STEAP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod PeriosteumBone
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STEAP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STEAP4

    SOURCE GeneReport for Unigene cluster: Hs.521008

    UniProtKB/Swiss-Prot: STEA4_HUMAN, Q687X5
    Tissue specificity: Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate.
    Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints
    of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages

        SABiosciences Custom PCR Arrays for STEAP4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP4

    Orthologs
    for STEAP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for STEAP4 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STEAP41 STEAP family member 4 72.8(n)
    75.39(a)    		   772063  XM_001235256.2  XP_001235257.2 
    lizard
    (Anolis carolinensis)    		 Reptilia STEAP46
    		 --
    		 70(a)
    		 1 ↔ 1
    		 6(19612072-19618504)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC060000.12   -- 74.64(n)    BC060000.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.127252 Transcribed sequence with weak similarity to protein more 75.61(n)    BI878750.1 


    ENSEMBL Gene Tree for STEAP4 (if available)
    TreeFam Gene Tree for STEAP4 (if available) 

    Paralogs
    for STEAP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STEAP4 gene
    STEAP22  STEAP1B2  STEAP12  STEAP32  
    6 SIMAP similar genes for STEAP4 using alignment to 2 protein entries:     STEA4_HUMAN (see all proteins):
    LOC392745    STEAP1    MGC87042    STEAP2    STEAP1B    STEAP3

    STEAP4 for paralogs           About GeneDecksing



    Genomic Variants
    for STEAP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 NCBI SNPs in STEAP4 are shown (see all 462)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs760182341,2
    		--87236973(+) GCCTTC/TTCTTT 3 -- ds50010--------
    rs81431,2
    		C,H--87237234(+) AAAGAA/GGTTTA 3 -- ut316Minor allele frequency- G:0.02MN NS EA NA 558
    rs119708411,2
    		C,H,--87239005(+) TTTTCC/TGTAAT 3 -- ut31 ese35Minor allele frequency- T:0.00NS EA WA 536
    rs96559601,2
    		H,--87239842(+) AATAAG/AAGTCA 3 -- ut31 ese35Minor allele frequency- A:0.00NS EA CSA 380
    rs343860751,2
    		C,--87240445(+) AAAAAA/GAGCAC 3 -- int12Minor allele frequency- G:0.06NA 122
    rs69576661,2
    		C,F,H,--87240822(+) GCTAAT/CGAGAA 3 -- int17Minor allele frequency- C:0.03NS EA NA 522
    rs794811841,2
    		C,F,--87241301(+) TTGTAA/GGGTTA 3 -- int11Minor allele frequency- G:0.03WA 118
    rs102652181,2
    		H--87241457(+) TATTAA/CGAAAT 3 -- int14Minor allele frequency- C:0.00NS EA 416
    rs774852741,2
    		C,--87242117(+) TATATG/TTGGAT 3 -- int10--------
    rs46170881,2
    		H--87242405(+) AATGTC/GTTAAA 3 -- int14Minor allele frequency- G:0.00NS EA 416

    HapMap Linkage Disequilibrium report for STEAP4 (87905744 - 87936209 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for STEAP4: --
    Human Gene Mutation Database (HGMD): STEAP4

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    Disorders / Diseases
    for STEAP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STEAP4 for disorders           About GeneDecksing

    OMIM gene information: 611098    OMIM disorders: --

    9 diseases for STEAP4:    About MalaCards
    prostatitis    prostate cancer    prostate cancer, progression of    insulin resistance
    essential hypertension    rheumatoid arthritis    hypertension    arthritis
    obesity

    3 Novoseek disease relationships for STEAP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 54 7 15836432 (1), 11443137 (1), 14988015 (1), 12967343 (1) (see all 6)
    insulin resistance 28.8 1 14988015 (1)
    tumors 19.3 6 11443137 (1), 14988015 (1), 12967343 (1), 19289123 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: STEAP4 (5 documents)

    Export disorders for STEAP4 gene to outside databases

    Publications
    for STEAP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STEAP4 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with STEAP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. (PubMed id 15897894)1, 2, 3 Korkmaz C.G....Saatcioglu F. (2005)
    2. Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. (PubMed id 11443137)1, 3, 9 Moldes M....Chambaut-Guerin A.M. (2001)
    3. Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. (PubMed id 19289123)1, 2, 9 Kralisch S....Fasshauer M. (2009)
    4. STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells. (PubMed id 19787193)1, 2 Tamura T. and Chiba J. (2009)
    5. Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance. (PubMed id 18381574)1, 2 Arner P....Dahlman I. (2008)
    6. Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans. (PubMed id 18430367)1, 2 Zhang C.M....Guo X.R. (2008)
    7. Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis. (PubMed id 19660107)2, 9 Inoue A.... Sumida T. (2009)
    8. STEAP4, a gene associated with insulin sensitivity, i s regulated by several adipokines in human adipocytes. (PubMed id 20127040)1, 9 Chen X....Guo X. (2010)
    9. Six-transmembrane epithelial antigen of prostate4 (STE AP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. (PubMed id 21633911)1 Tanaka Y....Sumida T. (2012)
    10. Six-transmembrane epithelial antigen of prostate 4 (ST EAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis. (PubMed id 22244520)1 Tanaka Y....Sumida T. (2012)

    External Searches for STEAP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing STEAP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79689 HGNC: 21923 AceView: TNFAIP9 Ensembl:ENSG00000127954 euGenes: HUgn79689
    ECgene: STEAP4 H-InvDB: STEAP4

    Other Databases showing STEAP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STEAP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STEAP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STEAP4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for STEAP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STEAP4 gene:
    Search GeneIP for patents involving STEAP4

    GeneCards and IP:
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