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Aliases for STEAP4 Gene

Aliases for STEAP4 Gene

  • STEAP Family Member 4 2 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 9 2 3 4
  • STAMP2 3 4 6
  • Six-Transmembrane Epithelial Antigen Of Prostate 4 3 4
  • SixTransMembrane Protein Of Prostate 2 3 4
  • TNFAIP9 3 4
  • TIARP 3 6
  • Tumor Necrosis-Alpha-Induced Adipose-Related Protein 3
  • Six Transmembrane Prostate Protein 2 3
  • Metalloreductase STEAP4 3
  • EC 1.16.1.- 4
  • EC 1.16.1 64

External Ids for STEAP4 Gene

Previous Symbols for STEAP4 Gene

  • TNFAIP9

Summaries for STEAP4 Gene

Entrez Gene Summary for STEAP4 Gene

  • The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for STEAP4 Gene

STEAP4 (STEAP Family Member 4) is a Protein Coding gene. Diseases associated with STEAP4 include prostate cancer. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is STEAP1.

UniProtKB/Swiss-Prot for STEAP4 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP4 Gene

Genomics for STEAP4 Gene

Genomic Location for STEAP4 Gene

Start:
88,276,429 bp from pter
End:
88,306,913 bp from pter
Size:
30,485 bases
Orientation:
Minus strand

Genomic View for STEAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STEAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP4 Gene

Regulatory Elements for STEAP4 Gene

Proteins for STEAP4 Gene

  • Protein details for STEAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q687X5-STEA4_HUMAN
    Recommended name:
    Metalloreductase STEAP4
    Protein Accession:
    Q687X5
    Secondary Accessions:
    • Q658Q9
    • Q687X4
    • Q8WWB0
    • Q9H5R1

    Protein attributes for STEAP4 Gene

    Size:
    459 amino acids
    Molecular mass:
    51981 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with and phosphorylates PTK2/FAK1.
    SequenceCaution:
    • Sequence=AAQ04064.1; Type=Frameshift; Positions=384; Evidence={ECO:0000305}; Sequence=BAB15559.1; Type=Frameshift; Positions=252, 364; Evidence={ECO:0000305}; Sequence=CAH56271.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STEAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP4 Gene

Proteomics data for STEAP4 Gene at MOPED

Selected DME Specific Peptides for STEAP4 Gene

Post-translational modifications for STEAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn323

Other Protein References for STEAP4 Gene

Domains for STEAP4 Gene

Protein Domains for STEAP4 Gene

UniProtKB/Swiss-Prot:

STEA4_HUMAN
Domain:
  • Contains 1 ferric oxidoreductase domain.:
    • Q687X5
Family:
  • Belongs to the STEAP family.:
    • Q687X5
genes like me logo Genes that share domains with STEAP4: view

No data available for Gene Families for STEAP4 Gene

Function for STEAP4 Gene

Molecular function for STEAP4 Gene

UniProtKB/Swiss-Prot Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
UniProtKB/Swiss-Prot Induction: By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).

Enzyme Numbers (IUBMB) for STEAP4 Gene

Gene Ontology (GO) - Molecular Function for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity --
GO:0008823 cupric reductase activity IBA --
GO:0046872 metal ion binding IEA --
GO:0052851 ferric-chelate reductase (NADPH) activity IBA --
genes like me logo Genes that share ontologies with STEAP4: view
genes like me logo Genes that share phenotypes with STEAP4: view

Animal Models for STEAP4 Gene

MGI Knock Outs for STEAP4:

miRNA for STEAP4 Gene

miRTarBase miRNAs that target STEAP4

No data available for Transcription Factor Targeting and HOMER Transcription for STEAP4 Gene

Localization for STEAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP4 Gene

Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STEAP4 Gene COMPARTMENTS Subcellular localization image for STEAP4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with STEAP4: view

Pathways for STEAP4 Gene

SuperPathways for STEAP4 Gene

No Data Available

Interacting Proteins for STEAP4 Gene

Gene Ontology (GO) - Biological Process for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006098 pentose-phosphate shunt --
GO:0015677 copper ion import IBA --
GO:0045444 fat cell differentiation ISS --
GO:0055072 iron ion homeostasis IEA --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with STEAP4: view

No data available for Pathways by source for STEAP4 Gene

Compounds for STEAP4 Gene

(3) HMDB Compounds for STEAP4 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Heme
  • (protoporphyrinato)iron
14875-96-8
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with STEAP4: view

Transcripts for STEAP4 Gene

Unigene Clusters for STEAP4 Gene

STEAP family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -
SP3:

Relevant External Links for STEAP4 Gene

GeneLoc Exon Structure for
STEAP4
ECgene alternative splicing isoforms for
STEAP4

Expression for STEAP4 Gene

mRNA expression in normal human tissues for STEAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP4 Gene

This gene is overexpressed in Adipose - Subcutaneous (4.6) and Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STEAP4 Gene

SOURCE GeneReport for Unigene cluster for STEAP4 Gene Hs.521008

mRNA Expression by UniProt/SwissProt for STEAP4 Gene

Q687X5-STEA4_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.
genes like me logo Genes that share expressions with STEAP4: view

Orthologs for STEAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STEAP4 36
  • 99.49 (n)
  • 99.56 (a)
STEAP4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STEAP4 36
  • 88.38 (n)
  • 86.27 (a)
STEAP4 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STEAP4 36
  • 89.67 (n)
  • 87.12 (a)
STEAP4 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Steap4 36
  • 82.06 (n)
  • 82.35 (a)
Steap4 16
Steap4 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia STEAP4 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Steap4 36
  • 82.57 (n)
  • 81.48 (a)
chicken
(Gallus gallus)
Aves STEAP4 36
  • 72.48 (n)
  • 74.51 (a)
STEAP4 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STEAP4 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia steap4 36
  • 68.59 (n)
  • 70.22 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7528 36
zebrafish
(Danio rerio)
Actinopterygii Dr.12725 36
steap4 36
  • 60.89 (n)
  • 60.31 (a)
steap4 37
  • 58 (a)
OneToOne
Species with no ortholog for STEAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP4 Gene

ENSEMBL:
Gene Tree for STEAP4 (if available)
TreeFam:
Gene Tree for STEAP4 (if available)

Paralogs for STEAP4 Gene

Paralogs for STEAP4 Gene

Selected SIMAP similar genes for STEAP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP4: view

Variants for STEAP4 Gene

Sequence variations from dbSNP and Humsavar for STEAP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8122 -- 88,276,856(-) CTCTG(A/G)TGGTT utr-variant-3-prime
rs8143 -- 88,276,561(+) AAAGA(A/G)GTTTA utr-variant-3-prime
rs43129 -- 88,282,218(+) ATCTC(A/G)GCTCA intron-variant
rs43130 -- 88,285,301(+) CATAT(A/G)TATGA intron-variant
rs43131 -- 88,285,396(+) CACAC(A/G)ACGTC intron-variant

Relevant External Links for STEAP4 Gene

HapMap Linkage Disequilibrium report
STEAP4
Human Gene Mutation Database (HGMD)
STEAP4

No data available for Structural Variations from Database of Genomic Variants (DGV) for STEAP4 Gene

Disorders for STEAP4 Gene

(1) MalaCards Diseases for STEAP4 Gene

Search for STEAP4 Gene in MalaCards »

(3) Novoseek inferred disease relationships for STEAP4 Gene

Disease -log(P) Hits PubMed IDs
necrosis 54 6
insulin resistance 28.8 1
tumors 19.3 5

Relevant External Links for STEAP4

Genetic Association Database (GAD)
STEAP4
Human Genome Epidemiology (HuGE) Navigator
STEAP4
genes like me logo Genes that share disorders with STEAP4: view

No data available for UniProtKB/Swiss-Prot for STEAP4 Gene

Publications for STEAP4 Gene

  1. Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. (PMID: 11443137) Moldes M. … Chambaut-GuAcrin A.M. (J. Biol. Chem. 2001) 2 3 23
  2. Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. (PMID: 19289123) Kralisch S. … Fasshauer M. (FEBS Lett. 2009) 3 4 23
  3. Molecular cloning and characterization of STAMP2, an androgen- regulated six transmembrane protein that is overexpressed in prostate cancer. (PMID: 15897894) Korkmaz C.G. … Saatcioglu F. (Oncogene 2005) 2 3 4
  4. Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance. (PMID: 18381574) Arner P. … Dahlman I. (J. Clin. Endocrinol. Metab. 2008) 3 4
  5. Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans. (PMID: 18430367) Zhang C.M. … Guo X.R. (Acta Pharmacol. Sin. 2008) 3 4

Products for STEAP4 Gene

  • antibodies-online peptides for STEAP4
  • antibodies-online antibodies for STEAP4
  • antibodies-online kits for STEAP4

Sources for STEAP4 Gene

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