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Aliases for STEAP4 Gene

Aliases for STEAP4 Gene

  • STEAP4 Metalloreductase 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 9 2 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 4 3 4
  • SixTransMembrane Protein Of Prostate 2 3 4
  • STEAP Family Member 4 2 3
  • TNFAIP9 3 4
  • STAMP2 3 4
  • Tumor Necrosis-Alpha-Induced Adipose-Related Protein 3
  • Six Transmembrane Prostate Protein 2 3
  • EC 1.16.1.- 4
  • EC 1.16.1 63
  • TIARP 3

External Ids for STEAP4 Gene

Previous HGNC Symbols for STEAP4 Gene

  • TNFAIP9

Previous GeneCards Identifiers for STEAP4 Gene

  • GC07M087552
  • GC07M087745
  • GC07M087900
  • GC07M082517
  • GC07M087905

Summaries for STEAP4 Gene

Entrez Gene Summary for STEAP4 Gene

  • The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for STEAP4 Gene

STEAP4 (STEAP4 Metalloreductase) is a Protein Coding gene. GO annotations related to this gene include phosphogluconate dehydrogenase (decarboxylating) activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP1.

UniProtKB/Swiss-Prot for STEAP4 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP4 Gene

Genomics for STEAP4 Gene

Regulatory Elements for STEAP4 Gene

Promoters for STEAP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STEAP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for STEAP4 Gene

Chromosome:
7
Start:
88,270,892 bp from pter
End:
88,306,913 bp from pter
Size:
36,022 bases
Orientation:
Minus strand

Genomic View for STEAP4 Gene

Genes around STEAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP4 Gene

Proteins for STEAP4 Gene

  • Protein details for STEAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q687X5-STEA4_HUMAN
    Recommended name:
    Metalloreductase STEAP4
    Protein Accession:
    Q687X5
    Secondary Accessions:
    • Q658Q9
    • Q687X4
    • Q8WWB0
    • Q9H5R1

    Protein attributes for STEAP4 Gene

    Size:
    459 amino acids
    Molecular mass:
    51981 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with and phosphorylates PTK2/FAK1.
    SequenceCaution:
    • Sequence=AAQ04064.1; Type=Frameshift; Positions=384; Evidence={ECO:0000305}; Sequence=BAB15559.1; Type=Frameshift; Positions=252, 364; Evidence={ECO:0000305}; Sequence=CAH56271.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STEAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP4 Gene

Proteomics data for STEAP4 Gene at MOPED

Selected DME Specific Peptides for STEAP4 Gene

Post-translational modifications for STEAP4 Gene

  • Glycosylation at Asn 323
  • Modification sites at PhosphoSitePlus

Other Protein References for STEAP4 Gene

Antibody Products

  • R&D Systems Antibodies for STEAP4 (STAMP2/STEAP4)

Domains & Families for STEAP4 Gene

Protein Domains for STEAP4 Gene

Suggested Antigen Peptide Sequences for STEAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q687X5

UniProtKB/Swiss-Prot:

STEA4_HUMAN :
  • Contains 1 ferric oxidoreductase domain.
  • Belongs to the STEAP family.
Domain:
  • Contains 1 ferric oxidoreductase domain.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP4: view

No data available for Gene Families for STEAP4 Gene

Function for STEAP4 Gene

Molecular function for STEAP4 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
UniProtKB/Swiss-Prot Induction:
By TNF and IL1B/interleukin-1 beta in adipose tissue. Up-regulated by androgens, including testosterone and dihydrotestosterone (DHT).

Enzyme Numbers (IUBMB) for STEAP4 Gene

genes like me logo Genes that share phenotypes with STEAP4: view

Animal Models for STEAP4 Gene

MGI Knock Outs for STEAP4:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STEAP4 Gene

Localization for STEAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP4 Gene

Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STEAP4 Gene COMPARTMENTS Subcellular localization image for STEAP4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
endosome 2

Gene Ontology (GO) - Cellular Components for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA,IBA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with STEAP4: view

Pathways & Interactions for STEAP4 Gene

SuperPathways for STEAP4 Gene

No Data Available

Interacting Proteins for STEAP4 Gene

Gene Ontology (GO) - Biological Process for STEAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015677 copper ion import IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with STEAP4: view

No data available for Pathways by source and SIGNOR curated interactions for STEAP4 Gene

Drugs & Compounds for STEAP4 Gene

(3) Drugs for STEAP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP4: view

Transcripts for STEAP4 Gene

Unigene Clusters for STEAP4 Gene

STEAP family member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -
SP3:

Relevant External Links for STEAP4 Gene

GeneLoc Exon Structure for
STEAP4
ECgene alternative splicing isoforms for
STEAP4

Expression for STEAP4 Gene

mRNA expression in normal human tissues for STEAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.6) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for STEAP4 Gene

This gene is overexpressed in Nasal epithelium (38.7) and Testis (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STEAP4 Gene



SOURCE GeneReport for Unigene cluster for STEAP4 Gene Hs.521008

mRNA Expression by UniProt/SwissProt for STEAP4 Gene

Q687X5-STEA4_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.
genes like me logo Genes that share expression patterns with STEAP4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for STEAP4 Gene

Orthologs for STEAP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STEAP4 35
  • 88.38 (n)
  • 86.27 (a)
STEAP4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STEAP4 35
  • 89.67 (n)
  • 87.12 (a)
STEAP4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Steap4 35
  • 82.06 (n)
  • 82.35 (a)
Steap4 16
Steap4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STEAP4 35
  • 99.49 (n)
  • 99.56 (a)
STEAP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Steap4 35
  • 82.57 (n)
  • 81.48 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia STEAP4 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves STEAP4 35
  • 72.48 (n)
  • 74.51 (a)
STEAP4 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STEAP4 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia steap4 35
  • 68.59 (n)
  • 70.22 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12725 35
steap4 35
  • 60.89 (n)
  • 60.31 (a)
steap4 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7528 35
Species with no ortholog for STEAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP4 Gene

ENSEMBL:
Gene Tree for STEAP4 (if available)
TreeFam:
Gene Tree for STEAP4 (if available)

Paralogs for STEAP4 Gene

Paralogs for STEAP4 Gene

(6) SIMAP similar genes for STEAP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP4: view

Variants for STEAP4 Gene

Sequence variations from dbSNP and Humsavar for STEAP4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1981529 - 88,284,046(+) TGATG(A/C/T)CAGAC reference, missense
rs34741656 - 88,283,906(-) ACCTT(A/G)CTCAT reference, missense
rs8122 -- 88,276,856(-) CTCTG(A/G)TGGTT utr-variant-3-prime
rs8143 -- 88,276,561(+) AAAGA(A/G)GTTTA utr-variant-3-prime
rs43129 -- 88,282,218(+) ATCTC(A/G)GCTCA intron-variant

Variation tolerance for STEAP4 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STEAP4 Gene

HapMap Linkage Disequilibrium report
STEAP4
Human Gene Mutation Database (HGMD)
STEAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STEAP4 Gene

Disorders for STEAP4 Gene

Relevant External Links for STEAP4

Genetic Association Database (GAD)
STEAP4
Human Genome Epidemiology (HuGE) Navigator
STEAP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STEAP4

No disorders were found for STEAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STEAP4 Gene

Publications for STEAP4 Gene

  1. Molecular cloning and characterization of STAMP2, an androgen- regulated six transmembrane protein that is overexpressed in prostate cancer. (PMID: 15897894) Korkmaz C.G. … Saatcioglu F. (Oncogene 2005) 2 3 4 67
  2. Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. (PMID: 11443137) Moldes M. … Chambaut-GuAcrin A.M. (J. Biol. Chem. 2001) 2 3 23
  3. STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes. (PMID: 20127040) Chen X. … Guo X. (Int. J. Mol. Med. 2010) 3 23
  4. Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. (PMID: 19289123) Kralisch S. … Fasshauer M. (FEBS Lett. 2009) 3 23
  5. STAMPing into Mitochondria. (PMID: 24643198) Yoo S.K. … Kim H.Y. (Int. J. Biol. Sci. 2014) 3

Products for STEAP4 Gene

Sources for STEAP4 Gene

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