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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STEAP3 Gene

protein-coding GIFtS: 59
GCID: GC02P119981

STEAP family member 3, metalloreductase

Explore 6 diseases affiliated with
STEAP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
STEAP Family Member 3, Metalloreductase¹ ²		1010001D01Rik²
TSAP6¹ ² ³ ⁵		Dudlin 2²
STMP3¹ ²		Dudulin 2²
Dudlin-2¹		Dudulin-2³
Six-Transmembrane Epithelial Antigen Of Prostate 3² ³		Metalloreductase STEAP3²
Tumor Suppressor-Activated Pathway Protein 6² ³		Six Transmembrane Prostate Protein 3²
HTSAP6¹		Tumor Suppressor PHyde²
HpHyde¹		Dudulin-2³
PHyde¹		EC 1.16.1.-³

External Ids:	HGNC: 24592¹	Entrez Gene: 55240²	Ensembl: ENSG00000115107⁷	OMIM: 609671⁵	UniProtKB: Q658P3³

Export aliases for STEAP3 gene to outside databases

Previous GC identifers: GC02P119698 GC02P112313

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3

Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.

Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+),

suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of

p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating

the secretion of proteins such as TCTP

Gene Wiki entry for STEAP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STEAP3 gene promoter:
AREB6 Spz1 p53 MyoD c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STEAP3 promoter sequence

Search SABiosciences Chromatin IP Primers for STEAP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.2

STEAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P119981: view genomic region (about GC identifiers)

Start:	119,981,384 bp from pter	End:	120,023,228 bp from pter
Size:	41,845 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3 (See protein sequence)

Recommended Name: Metalloreductase STEAP3

Size: 488 amino acids; 54601 Da

Cofactor: FAD (By similarity)

Cofactor: NADP

Subunit: Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP

Subcellular location: Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like

structures at the plasma membrane and around the nucleus

Caution: Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is

probably not the case (PubMed:12866033)

2 PDB 3D structures from and Proteopedia for STEAP3:

2VNS (3D)

2VQ3 (3D)

Secondary accessions: A8K6E3 Q4VBR2 Q4ZG36 Q53SQ8 Q7Z389 Q86SF6 Q8NEW6 Q8TDP3 Q8TF03 Q9NVB5

Alternative splicing: 4 isoforms: Q658P3-1 Q658P3-2 Q658P3-3 Q658P3-4

Explore the universe of human proteins at neXtProt for STEAP3: NX_Q658P3

Post-translational modifications:

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a

glycosylation-independent manner¹

Glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q658P3

STEAP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001008410.1 NP_060704.2 NP_878919.2

ENSEMBL proteins:

ENSP00000376822 ENSP00000376818 ENSP00000386510 ENSP00000376819 ENSP00000376820

ENSP00000346961 ENSP00000396214 ENSP00000396873

Reactome Protein details: Q658P3
Human Recombinant Protein Products:

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	Novus Biologicals STEAP3 Protein Novus Biologicals STEAP3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STEAP3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	--	--
GO:0005771	multivesicular body	IDA	15319436
GO:0005886	plasma membrane	IEA	--
GO:0010008	endosome membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

STEAP3 for ontologies About GeneDecksing

STEAP3 Antibody Products:

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	ThermoFisher Antibodies for STEAP3

Assay Products for STEAP3:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STEAP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STEAP3 for domains About GeneDecksing

3 InterPro domains/families:

IPR004455 NADP_OxRdtase_F420

IPR013130 Fe3_Rdtase_TM_dom

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q658P3

ProtoNet protein and cluster: Q658P3

UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3

Similarity: Belongs to the STEAP family

Similarity: Contains 1 ferric oxidoreductase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3

Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.

Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+),

suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of

p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating

the secretion of proteins such as TCTP

Induction: By p53/TP53

Enzyme Number (IUBMB): EC 1.16.1.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 3): STEAP3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP3
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP3 (see all 28):
		hsa-miR-345 hsa-let-7d hsa-miR-202 hsa-miR-128 hsa-miR-4299 hsa-let-7c hsa-miR-486-3p hsa-miR-520a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: STEAP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STEAP3 (see all 7) OriGene shRNA RFP: STEAP3 OriGene siRNA: STEAP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for STEAP3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): STEAP3 (NM_018234)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STEAP3
		Search LifeMap BioReagents cell lines for STEAP3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000293	ferric-chelate reductase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0016491	oxidoreductase activity	--	--
GO:0046872	metal ion binding	IEA	--

STEAP3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for STEAP3:

G0/1 arrest

Increased G1 DNA content

Animal Models:
Mouse knock-outs for STEAP3: Steap3^tm1Mdf Steap3^tm1.1Atel
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Steap3):

cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	reproductive system

STEAP3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Insulin receptor recycling

Transferrin endocytosis and recycling

0.79

Iron uptake and transport

0.56

iron metabolism in placenta

iron metabolism in placenta

1.00

Direct p53 effectors

Direct p53 effectors

1.00

p53 signaling pathway

p53 signaling pathway

1.00

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for STEAP3

	iron metabolism in placenta
	Direct p53 effectors

3 Reactome Pathways for STEAP3

	Transmembrane transport of small molecules
	Iron uptake and transport
	Transferrin endocytosis and recycling

1 Kegg Pathway (Kegg details for STEAP3):

p53 signaling pathway

STEAP3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for STEAP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for STEAP3 (Q658P3³ ENSP00000376822⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TPT1	P13693³, ENSP00000368350⁴	I2D: score=1 STRING: ENSP00000368350
BNIP3L	O60238³, ENSP00000370003⁴	I2D: score=2 STRING: ENSP00000370003
PKMYT1	Q99640³, ENSP00000262300⁴	I2D: score=2 STRING: ENSP00000262300
TF	ENSP00000264998⁴	STRING: ENSP00000264998
TFRC	ENSP00000353224⁴	STRING: ENSP00000353224

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006826	iron ion transport	--	--
GO:0006879	cellular iron ion homeostasis	TAS	--
GO:0006915	apoptotic process	IEA	--
GO:0006917	induction of apoptosis	IEA	--
GO:0007049	cell cycle	IEA	--

STEAP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STEAP3

5 HMDB Compounds for STEAP3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Copper	Cu (see all 2)	7440-50-8	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Iron	Armco iron (see all 19)	7439-89-6	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

Search CenterWatch for drugs/clinical trials and news about STEAP3 / STEA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STEAP3 gene (3 alternative transcripts):

NM_001008410.1 NM_018234.2 NM_182915.2

Unigene Cluster for STEAP3:

STEAP family member 3, metalloreductase

Hs.647822 [show with all ESTs]

Unigene Representative Sequence: AL833624

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393110 ENST00000393106(uc002tlp.3) ENST00000409811 ENST00000393107

ENST00000393108(uc002tlr.3 uc010fle.3) ENST00000354888(uc002tlq.3)

ENST00000425223 ENST00000450943

miRNA Products:		OriGene 3'-UTR Clone (see all 3): STEAP3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP3
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP3 (see all 28):
		hsa-miR-345 hsa-let-7d hsa-miR-202 hsa-miR-128 hsa-miR-4299 hsa-let-7c hsa-miR-486-3p hsa-miR-520a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: STEAP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP3

Additional cDNA sequence:

AF238864.1 AF262322.1 AF423424.1 AK001691.1 AK024163.1 AK291608.1 AL833624.1 AY029585.1

AY082673.1 AY214461.1 BC042150.1 BC095421.1 BX538047.1

10 DOTS entries:

DT.100059332 DT.213855 DT.95372135 DT.95258870 DT.92430352 DT.100059330 DT.120950990 DT.100795388

DT.120950994 DT.91952417

24/214 AceView cDNA sequences (see all 214):

CA488941 BQ882130 AU124448 BM789603 BQ448110 AW275484 BF222570 CR614870

BM677810 AI669713 BM850763 AI206292 BQ020188 CB991814 BC042150 BM700045

AY029585 CR596003 AI202008 AI078073 BQ948163 BQ015018 BU527244 CB993461

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STEAP3 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11
SP1:					-		-		-				-																		-
SP2:					-		-		-		-		-
SP3:					-		-		-		-		-																		-
SP4:					-		-		-		-
SP5:									-		-		-

ECgene alternative splicing isoforms for STEAP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STEAP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGGAAAT

About this image

STEAP3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Bone

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See STEAP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STEAP3

SOURCE GeneReport for Unigene cluster: Hs.647822

UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3

Tissue specificity: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in

hepatocellular carcinoma

SABiosciences Custom PCR Arrays for STEAP3

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for STEAP3 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Steap3^{1 , 5}	STEAP family member 3^{1, 5}	84.97(n)¹ 86.89(a)¹		1 (52.66 cM)⁵ 68428¹ NM_001085409.1¹ NP_001078878.1¹ 120190757⁵
chicken (Gallus gallus)	Aves	STEAP3¹	STEAP family member 3	72.35(n) 71.52(a)		424275 XM_422122.3 XP_422122.3
lizard (Anolis carolinensis)	Reptilia	STEAP3⁶	--	70(a)	1 ↔ 1	GL343497.1(224404-238246)
zebrafish (Danio rerio)	Actinopterygii	steap3¹	STEAP family member 3, metalloreductase	59.13(n) 54.57(a)		100320152 XM_002663293.1 XP_002663339.1

ENSEMBL Gene Tree for STEAP3 (if available)
TreeFam Gene Tree for STEAP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STEAP3 gene

STEAP2² STEAP1B² STEAP4² STEAP1²

6 SIMAP similar genes for STEAP3 using alignment to 2 protein entries: STEA3_HUMAN (see all proteins):

STEAP2 LOC392745 STEAP1 STEAP1B STEAP4 MGC87042

STEAP3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7557910^1,2	C,H,	--	119979436(+)	`GTGGGT/CGGTGG`	3	--	us2k¹		13		NA WA CSA EA	376
rs144684113^1,2		--	119979676(+)	`ATGGAA/GAGCCC`	3	--	us2k¹		0	--	--	--	--
rs181242653^1,2		--	119979686(+)	`CCACAA/GAAAGA`	3	--	us2k¹		0	--	--	--	--
rs78091564^1,2	C,F,	--	119979724(+)	`NNNNTG/AGAAGA`	3	--	us2k¹		2		WA NA	238
rs148499725^1,2		--	119979758(+)	`AGCTCA/GGTTTC`	3	--	us2k¹		0	--	--	--	--
rs76368217^1,2	F,	--	119979960(+)	`GGAACC/TTCCAT`	3	--	us2k¹		1		NA	120
rs186229075^1,2		--	119980055(+)	`TTGCCA/GTAAGA`	3	--	us2k¹		0	--	--	--	--
rs147494129^1,2		--	119980163(+)	`ATTCGC/GGTAGG`	3	--	us2k¹		0	--	--	--	--
rs838059^1,2	C,F,H,	--	119980250(-)	`TAAAGC/GGCCTT`	3	--	us2k¹		13		NS EA WA NA CSA	787
rs838058^1,2	C,F,	--	119980273(-)	`TCCCTC/GTGGAG`	3	--	us2k¹		6		MN NA WA EA	546

HapMap Linkage Disequilibrium report for STEAP3 (119981384 - 120023228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STEAP3
2 CNVs: 50270 50269
Human Gene Mutation Database (HGMD): STEAP3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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STEAP3 for disorders           About GeneDecksing

OMIM gene information: 609671    OMIM disorders: --

6 diseases for STEAP3:    About MalaCards

prostatitis microcytic anemia hepatocellular carcinoma prostate cancer

anemia carcinoma

Human Genome Epidemiology (HuGE) Navigator: STEAP3 (2 documents)

Export disorders for STEAP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STEAP3 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with STEAP3)

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world of online information

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. (PubMed id 12606722)^{1, 2, 3} Passer B.J....Telerman A. (2003)
Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. (PubMed id 22624035)^{1, 2} Wan C.... Wang L. (2012)
Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. (PubMed id 18495927)^{1, 2} Sendamarai A.K....Lawrence C.M. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. (PubMed id 15319436)^{1, 2} Amzallag N.... Telerman A. (2004)
Human STEAP3 maintains tumor growth under hypoferric condition. (PubMed id 21871451)¹ Isobe T....Akashi K. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55240	HGNC: 24592	AceView: TSAP6	Ensembl:ENSG00000115107	euGenes: HUgn55240
ECgene: STEAP3	Kegg: 55240	H-InvDB: STEAP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STEAP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STEAP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for STEAP3 gene:
Search GeneIP for patents involving STEAP3

GeneCards and IP:
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STEAP family member 3, metalloreductase

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STEAP family member 3, metalloreductase

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