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Aliases for STEAP3 Gene

Aliases for STEAP3 Gene

  • STEAP Family Member 3, Metalloreductase 2 3
  • TSAP6 3 4 6
  • Six-Transmembrane Epithelial Antigen Of Prostate 3 3 4
  • Tumor Suppressor-Activated Pathway Protein 6 3 4
  • Dudulin-2 3 4
  • AHMIO2 3 6
  • HTSAP6 3 4
  • HpHyde 3 4
  • PHyde 3 4
  • Six Transmembrane Prostate Protein 3 3
  • Metalloreductase STEAP3 3
  • Tumor Suppressor PHyde 3
  • 1010001D01Rik 3
  • EC 1.16.1.- 4
  • Dudulin 2 3
  • Dudlin 2 3
  • Dudlin-2 3
  • STMP3 3

External Ids for STEAP3 Gene

Previous GeneCards Identifiers for STEAP3 Gene

  • GC02P119698
  • GC02P119981
  • GC02P112313

Summaries for STEAP3 Gene

GeneCards Summary for STEAP3 Gene

STEAP3 (STEAP Family Member 3, Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP3 include anemia, hypochromic microcytic, with iron overload 2 and severe congenital hypochromic anemia with ringed sideroblasts. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Direct p53 effectors. GO annotations related to this gene include ferric-chelate reductase activity. An important paralog of this gene is STEAP1.

UniProtKB/Swiss-Prot for STEAP3 Gene

  • Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Gene Wiki entry for STEAP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP3 Gene

Genomics for STEAP3 Gene

Regulatory Elements for STEAP3 Gene

Genomic Location for STEAP3 Gene

Start:
119,222,730 bp from pter
End:
119,265,652 bp from pter
Size:
42,923 bases
Orientation:
Plus strand

Genomic View for STEAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STEAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP3 Gene

Proteins for STEAP3 Gene

  • Protein details for STEAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q658P3-STEA3_HUMAN
    Recommended name:
    Metalloreductase STEAP3
    Protein Accession:
    Q658P3
    Secondary Accessions:
    • A8K6E3
    • Q4VBR2
    • Q4ZG36
    • Q53SQ8
    • Q7Z389
    • Q86SF6
    • Q8NEW6
    • Q8TDP3
    • Q8TF03
    • Q9NVB5

    Protein attributes for STEAP3 Gene

    Size:
    488 amino acids
    Molecular mass:
    54601 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=NADP(+); Xref=ChEBI:CHEBI:58349;
    Quaternary structure:
    • Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP.

    Three dimensional structures from OCA and Proteopedia for STEAP3 Gene

    Alternative splice isoforms for STEAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP3 Gene

Proteomics data for STEAP3 Gene at MOPED

Post-translational modifications for STEAP3 Gene

  • Glycosylated.
  • Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.
  • Ubiquitination at Lys339, Lys472, and Lys484
  • Glycosylation at Asn256 and Asn344
  • Modification sites at PhosphoSitePlus

Other Protein References for STEAP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for STEAP3 Gene

Domains for STEAP3 Gene

Protein Domains for STEAP3 Gene

Suggested Antigen Peptide Sequences for STEAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q658P3

UniProtKB/Swiss-Prot:

STEA3_HUMAN :
  • Q658P3
Domain:
  • Contains 1 ferric oxidoreductase domain.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP3: view

No data available for Gene Families for STEAP3 Gene

Function for STEAP3 Gene

Molecular function for STEAP3 Gene

UniProtKB/Swiss-Prot Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Enzyme Numbers (IUBMB) for STEAP3 Gene

Gene Ontology (GO) - Molecular Function for STEAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000293 ferric-chelate reductase activity IEA --
GO:0005515 protein binding IPI 22624035
GO:0008823 cupric reductase activity IBA --
GO:0046872 metal ion binding IEA --
GO:0052851 ferric-chelate reductase (NADPH) activity IBA --
genes like me logo Genes that share ontologies with STEAP3: view
genes like me logo Genes that share phenotypes with STEAP3: view

Animal Models for STEAP3 Gene

MGI Knock Outs for STEAP3:

miRNA for STEAP3 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for STEAP3 Gene

Localization for STEAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP3 Gene

Endosome membrane; Multi-pass membrane protein. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STEAP3 Gene COMPARTMENTS Subcellular localization image for STEAP3 gene
Compartment Confidence
endosome 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for STEAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005771 multivesicular body IDA 15319436
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with STEAP3: view

Pathways for STEAP3 Gene

genes like me logo Genes that share pathways with STEAP3: view

Pathways by source for STEAP3 Gene

Gene Ontology (GO) - Biological Process for STEAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006826 iron ion transport --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0009306 protein secretion IMP 22624035
genes like me logo Genes that share ontologies with STEAP3: view

Compounds for STEAP3 Gene

(5) HMDB Compounds for STEAP3 Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Heme
  • (protoporphyrinato)iron
14875-96-8
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with STEAP3: view

Transcripts for STEAP3 Gene

Unigene Clusters for STEAP3 Gene

STEAP family member 3, metalloreductase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for STEAP3 Gene

GeneLoc Exon Structure for
STEAP3
ECgene alternative splicing isoforms for
STEAP3

Expression for STEAP3 Gene

mRNA expression in normal human tissues for STEAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP3 Gene

This gene is overexpressed in Liver (16.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STEAP3 Gene

SOURCE GeneReport for Unigene cluster for STEAP3 Gene Hs.647822

mRNA Expression by UniProt/SwissProt for STEAP3 Gene

Q658P3-STEA3_HUMAN
Tissue specificity: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.
genes like me logo Genes that share expressions with STEAP3: view

Orthologs for STEAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STEAP3 35
  • 99.04 (n)
  • 98.98 (a)
STEAP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STEAP3 35
  • 87.47 (n)
  • 87.27 (a)
STEAP3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STEAP3 35
  • 86.56 (n)
  • 86.97 (a)
STEAP3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Steap3 35
  • 84.97 (n)
  • 86.89 (a)
Steap3 16
Steap3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STEAP3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Steap3 35
  • 84.56 (n)
  • 85.86 (a)
chicken
(Gallus gallus)
Aves STEAP3 35
  • 72.35 (n)
  • 71.52 (a)
STEAP3 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STEAP3 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii steap3 35
  • 58.95 (n)
  • 54.55 (a)
steap3 36
  • 53 (a)
OneToOne
Species with no ortholog for STEAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP3 Gene

ENSEMBL:
Gene Tree for STEAP3 (if available)
TreeFam:
Gene Tree for STEAP3 (if available)

Paralogs for STEAP3 Gene

Paralogs for STEAP3 Gene

Selected SIMAP similar genes for STEAP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP3: view

Variants for STEAP3 Gene

Sequence variations from dbSNP and Humsavar for STEAP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs708670 -- 119,229,661(-) TCTCC(C/T)GGCTT intron-variant
rs708671 -- 119,229,711(+) TTAAG(C/T)GCCCA intron-variant
rs708672 -- 119,229,778(-) ATCTC(A/C)AATCT intron-variant
rs708673 -- 119,230,150(-) GTATT(C/G)TATTG intron-variant
rs708674 -- 119,234,653(-) TTATT(C/T)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STEAP3 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874957 CNV Loss 21882294
nsv874958 CNV Gain 21882294
nsv519595 CNV Loss 19592680
nsv874959 CNV Loss 21882294

Relevant External Links for STEAP3 Gene

HapMap Linkage Disequilibrium report
STEAP3
Human Gene Mutation Database (HGMD)
STEAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP3 Gene

Disorders for STEAP3 Gene

(1) OMIM Diseases for STEAP3 Gene (609671)

UniProtKB/Swiss-Prot

STEA3_HUMAN
  • Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. {ECO:0000269 PubMed:22031863}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STEAP3

Genetic Association Database (GAD)
STEAP3
Human Genome Epidemiology (HuGE) Navigator
STEAP3
genes like me logo Genes that share disorders with STEAP3: view

Publications for STEAP3 Gene

  1. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. (PMID: 12606722) Passer B.J. … Telerman A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. (PMID: 15319436) Amzallag N. … Telerman A. (J. Biol. Chem. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 48

Products for STEAP3 Gene

  • antibodies-online peptides for STEAP3
  • antibodies-online antibodies for STEAP3
  • antibodies-online kits for STEAP3

Sources for STEAP3 Gene

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