Aliases for STEAP3 Gene
External Ids for STEAP3 Gene
Previous GeneCards Identifiers for STEAP3 Gene
GeneCards Summary for STEAP3 Gene
STEAP3 (STEAP Family Member 3, Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP3 include anemia, hypochromic microcytic, with iron overload 2 and severe congenital hypochromic anemia with ringed sideroblasts. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Direct p53 effectors. GO annotations related to this gene include ferric-chelate reductase activity. An important paralog of this gene is STEAP1.
UniProtKB/Swiss-Prot for STEAP3 Gene
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.