Aliases for STEAP3 Gene
External Ids for STEAP3 Gene
Previous GeneCards Identifiers for STEAP3 Gene
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
GeneCards Summary for STEAP3 Gene
STEAP3 (STEAP3 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP3 include Anemia, Hypochromic Microcytic, With Iron Overload 2 and Severe Congenital Hypochromic Anemia With Ringed Sideroblasts. Among its related pathways are Gene Expression and p53 signaling pathway. GO annotations related to this gene include cupric reductase activity and ferric-chelate reductase activity. An important paralog of this gene is STEAP1.
UniProtKB/Swiss-Prot for STEAP3 Gene
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.