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STEAP3 Gene

protein-coding   GIFtS: 62
GCID: GC02P119981

STEAP Family Member 3, Metalloreductase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STEAP Family Member 3, Metalloreductase1 2     Dudlin 22
TSAP62 3 5     dudlin-22
Six-Transmembrane Epithelial Antigen Of Prostate 32 3     Dudulin 22
Tumor Suppressor-Activated Pathway Protein 62 3     dudulin-22
hTSAP62 3     Metalloreductase STEAP32
hpHyde2 3     Six Transmembrane Prostate Protein 32
pHyde2 3     Tumor Suppressor PHyde2
AHMIO22 5     Dudulin-23
1010001D01Rik2     EC 1.16.1.-3
STMP32     

External Ids:    HGNC: 245921   Entrez Gene: 552402   Ensembl: ENSG000001151077   OMIM: 6096715   UniProtKB: Q658P33   

Export aliases for STEAP3 gene to outside databases

Previous GC identifers: GC02P119698 GC02P112313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STEAP3 Gene:
STEAP3 (STEAP family member 3, metalloreductase) is a protein-coding gene. Diseases associated with STEAP3 include hypochromic microcytic anemia with iron overload 2, and microcytic anemia. GO annotations related to this gene include ferric-chelate reductase activity. An important paralog of this gene is STEAP2.

UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3
Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.
Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+),
suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of
p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by
facilitating the secretion of proteins such as TCTP

Gene Wiki entry for STEAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STEAP3 gene promoter:
         AREB6   Spz1   p53   MyoD   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTEAP3 promoter sequence
   Search Chromatin IP Primers for STEAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STEAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.2

STEAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P119981:  view genomic region     (about GC identifiers)

Start:
119,981,384 bp from pter      End:
120,023,228 bp from pter
Size:
41,845 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3 (See protein sequence)
Recommended Name: Metalloreductase STEAP3  
Size: 488 amino acids; 54601 Da
Cofactor: FAD (By similarity)
Cofactor: NADP
Subunit: Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP
Caution: Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it
is probably not the case (PubMed:12866033)
2 PDB 3D structures from and Proteopedia for STEAP3:
2VNS (3D)        2VQ3 (3D)    
Secondary accessions: A8K6E3 Q4VBR2 Q4ZG36 Q53SQ8 Q7Z389 Q86SF6 Q8NEW6 Q8TDP3 Q8TF03 Q9NVB5
Alternative splicing: 4 isoforms:  Q658P3-1   Q658P3-2   Q658P3-3   Q658P3-4   

Explore the universe of human proteins at neXtProt for STEAP3: NX_Q658P3

Explore proteomics data for STEAP3 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a
    glycosylation-independent manner1
  • Glycosylated1
  • Ubiquitination2 at Lys339, Lys472, Lys484
  • Glycosylation2 at Asn256, Asn344
  • Modification sites at PhosphoSitePlus

  • See STEAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008410.1  NP_060704.2  NP_878919.2  

    ENSEMBL proteins: 
     ENSP00000376822   ENSP00000376818   ENSP00000386510   ENSP00000376819   ENSP00000376820  
     ENSP00000346961   ENSP00000396214   ENSP00000396873  
    Reactome Protein details: Q658P3

    STEAP3 Human Recombinant Protein Products:

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    Novus Biologicals STEAP3 Protein
    Novus Biologicals STEAP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STEAP3

    STEAP3 Antibody Products:

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    STEAP3 Assay Products:

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    Cloud-Clone Corp. ELISAs for STEAP3
    Cloud-Clone Corp. CLIAs for STEAP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013130 Fe3_Rdtase_TM_dom
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q658P3

    ProtoNet protein and cluster: Q658P3

    UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3
    Similarity: Belongs to the STEAP family
    Similarity: Contains 1 ferric oxidoreductase domain


    STEAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STEA3_HUMAN, Q658P3
    Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.
    Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+),
    suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of
    p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by
    facilitating the secretion of proteins such as TCTP
    Induction: By p53/TP53

         Enzyme Number (IUBMB): EC 1.16.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000293ferric-chelate reductase activity IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    STEAP3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STEAP3:
     G0/1 arrest  Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Steap3):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  reproductive system 

    STEAP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STEAP3: Steap3tm1.1Atel Steap3tm1Mdf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STEAP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STEAP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STEAP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STEAP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target STEAP3:
    hsa-let-7b-5p (MIRT052160), hsa-mir-98-5p (MIRT027494), hsa-mir-16-5p (MIRT031486), hsa-mir-92a-3p (MIRT049382)

    Block miRNA regulation of human, mouse, rat STEAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STEAP3 (see all 28):
    hsa-miR-345 hsa-let-7d hsa-miR-202 hsa-miR-128 hsa-miR-4299 hsa-let-7c hsa-miR-486-3p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTEAP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STEAP3
    Predesigned siRNA for gene silencing in human, mouse, rat STEAP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STEAP3

    Clone
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    OriGene clones in human, mouse for STEAP3 (see all 17)
    OriGene ORF clones in mouse, rat for STEAP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): STEAP3 (NM_018234)
    Sino Biological Human cDNA Clone for STEAP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for STEAP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for STEAP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STEA3_HUMAN, Q658P3: Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to
    vesicular-like structures at the plasma membrane and around the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome ----
    GO:0005771multivesicular body IDA15319436
    GO:0005886plasma membrane IEA--
    GO:0010008endosome membrane TAS--
    GO:0016021integral component of membrane IEA--

    STEAP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STEAP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Transferrin endocytosis and recycling0.74
    Iron uptake and transport0.70
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3p53 signaling pathway
    p53 signaling pathway0.41
    4Iron metabolism in placenta
    Iron metabolism in placenta
    5Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for STEAP3
        Iron metabolism in placenta
    Direct p53 effectors


    1 Reactome Pathway for STEAP3
        Transferrin endocytosis and recycling


    1 Kegg Pathway  (Kegg details for STEAP3):
        p53 signaling pathway


    STEAP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STEAP3
    Interactions:

        Search GeneGlobe Interaction Network for STEAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for STEAP3 (Q658P33 ENSP000003768224) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPT1P136933, ENSP000003683504I2D: score=1 STRING: ENSP00000368350
    BNIP3LO602383, ENSP000003700034I2D: score=2 STRING: ENSP00000370003
    PKMYT1Q996403, ENSP000002623004I2D: score=2 STRING: ENSP00000262300
    TFENSP000002649984STRING: ENSP00000264998
    TFRCENSP000003532244STRING: ENSP00000353224
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006826iron ion transport ----
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0009306protein secretion IMP--

    STEAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STEAP3 (STEA3)

    5 HMDB Compounds for STEAP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STEAP3 gene (3 alternative transcripts): 
    NM_001008410.1  NM_018234.2  NM_182915.2  

    Unigene Cluster for STEAP3:

    STEAP family member 3, metalloreductase
    Hs.647822  [show with all ESTs]
    Unigene Representative Sequence: AL833624
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393110 ENST00000393106(uc002tlp.3) ENST00000409811 ENST00000393107
    ENST00000393108(uc002tlr.3 uc010fle.3) ENST00000354888(uc002tlq.3)
    ENST00000425223 ENST00000450943
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STEAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STEAP3 (see all 28):
    hsa-miR-345 hsa-let-7d hsa-miR-202 hsa-miR-128 hsa-miR-4299 hsa-let-7c hsa-miR-486-3p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidSTEAP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STEAP3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): STEAP3 (NM_018234)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP3
    Primer
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    OriGene qPCR primer pairs and template standards for STEAP3
    OriGene qSTAR qPCR primer pairs in human, mouse for STEAP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STEAP3
      QuantiTect SYBR Green Assays in human, mouse, rat STEAP3
      QuantiFast Probe-based Assays in human, mouse, rat STEAP3

    Additional mRNA sequence: 

    AF238864.1 AF262322.1 AF423424.1 AK001691.1 AK024163.1 AK291608.1 AL833624.1 AY029585.1 
    AY082673.1 AY214461.1 BC042150.1 BC095421.1 BX538047.1 

    10 DOTS entries:

    DT.100059332  DT.213855  DT.95372135  DT.95258870  DT.92430352  DT.100059330  DT.120950990  DT.100795388 
    DT.120950994  DT.91952417 

    Selected AceView cDNA sequences (see all 214):

    CR596003 AI078073 CB991814 CR614870 CA488941 CB993461 BM850763 AW275484 
    BF222570 BM789603 AI669713 AI202008 BQ448110 AU124448 BM700045 BQ882130 
    AY029585 AI206292 BM712396 BM677810 BU527244 BQ948163 BQ020188 BC042150 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STEAP3 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -     -           -                                                     -                     
    SP2:              -     -     -     -     -                                                                           
    SP3:              -     -     -     -     -                                                     -                     
    SP4:              -     -     -     -                                                                                 
    SP5:                          -     -     -                                                                           


    ECgene alternative splicing isoforms for STEAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STEAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGGAAAT
    STEAP3 Expression
    About this image


    STEAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Stylopod Long Bone
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    STEAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STEAP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647822

    UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3
    Tissue specificity: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated
    in hepatocellular carcinoma

        Custom PCR Arrays for STEAP3
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    QuantiFast Probe-based Assays in human, mouse, rat STEAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STEAP3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Steap31 , 5 STEAP family member 31, 5 84.97(n)1
    86.89(a)1
      1 (52.66 cM)5
    684281  NM_001085409.11  NP_001078878.11 
     1201907575 
    chicken
    (Gallus gallus)
    Aves STEAP31 STEAP family member 3, metalloreductase 72.35(n)
    71.52(a)
      424275  XM_004942970.1  XP_004943027.1 
    lizard
    (Anolis carolinensis)
    Reptilia STEAP36
    STEAP family member 3, metalloreductase
    63(a)
    1 ↔ 1
    GL343497.1(219587-265959)
    zebrafish
    (Danio rerio)
    Actinopterygii steap31 STEAP family member 3, metalloreductase 58.95(n)
    54.55(a)
      100320152  XM_002663293.2  XP_002663339.1 


    ENSEMBL Gene Tree for STEAP3 (if available)
    TreeFam Gene Tree for STEAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STEAP3 gene
    STEAP22  STEAP1B2  STEAP42  STEAP12  
    6 SIMAP similar genes for STEAP3 using alignment to 2 protein entries:     STEA3_HUMAN (see all proteins):
    STEAP2    LOC392745    STEAP1    STEAP1B    STEAP4    MGC87042

    STEAP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STEAP3 (see all 1123)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75579101,2
    C,H--119979436(+) GTGGGT/CGGTGG 3 -- us2k113Minor allele frequency- C:0.00NA WA CSA EA 376
    rs1446841131,2
    --119979676(+) ATGGAA/GAGCCC 3 -- us2k10--------
    rs1812426531,2
    --119979686(+) CCACAA/GAAAGA 3 -- us2k10--------
    rs780915641,2
    C,F--119979724(+) ATGCTG/AGAAGA 3 -- us2k12Minor allele frequency- A:0.05WA NA 238
    rs1484997251,2
    --119979758(+) AGCTCA/GGTTTC 3 -- us2k10--------
    rs763682171,2
    F--119979960(+) GGAACC/TTCCAT 3 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1862290751,2
    C--119980055(+) TTGCCA/GTAAGA 3 -- us2k10--------
    rs1474941291,2
    --119980163(+) ATTCGC/GGTAGG 3 -- us2k10--------
    rs8380591,2
    C,F,H--119980250(-) TAAAGC/GGCCTT 3 -- us2k113Minor allele frequency- G:0.47NS EA WA NA CSA 787
    rs8380581,2
    C,F--119980273(-) TCCCTC/GTGGAG 3 -- us2k16Minor allele frequency- G:0.41MN NA WA EA 546

    HapMap Linkage Disequilibrium report for STEAP3 (119981384 - 120023228 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STEAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874959CNV Loss21882294
    nsv519595CNV Loss19592680
    nsv874957CNV Loss21882294
    nsv459119CNV Gain19166990
    nsv874958CNV Gain21882294

    Human Gene Mutation Database (HGMD): STEAP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STEAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for STEAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609671   
    OMIM disorders: 615234  
    UniProtKB/Swiss-Prot: STEA3_HUMAN, Q658P3
  • Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease
    characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia,
    erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for STEAP3:    
    About MalaCards
    hypochromic microcytic anemia with iron overload 2    microcytic anemia    prostatitis    hepatocellular carcinoma
    prostate cancer


    STEAP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STEAP3
    Human Genome Epidemiology (HuGE) Navigator: STEAP3 (2 documents)

    Export disorders for STEAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STEAP3 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with STEAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. (PubMed id 12606722)1, 2, 3 Passer B.J....Telerman A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. (PubMed id 22624035)1, 2 Wan C.... Wang L. (PLoS ONE 2012)
    3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. (PubMed id 18495927)1, 2 Sendamarai A.K.... Lawrence C.M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. (PubMed id 15319436)1, 2 Amzallag N.... Telerman A. (J. Biol. Chem. 2004)
    8. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (PubMed id 23958962)1 Gelernter J....Farrer L. (Mol. Psychiatry 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Human STEAP3 maintains tumor growth under hypoferric condition. (PubMed id 21871451)1 Isobe T....Akashi K. (Exp. Cell Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55240 HGNC: 24592 AceView: TSAP6 Ensembl:ENSG00000115107 euGenes: HUgn55240
    ECgene: STEAP3 Kegg: 55240 H-InvDB: STEAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STEAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STEAP3 gene:
    Search GeneIP for patents involving STEAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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