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Aliases for STEAP2 Gene

Aliases for STEAP2 Gene

  • STEAP Family Member 2, Metalloreductase 2 3
  • PCANAP1 3 4 6
  • STAMP1 3 4 6
  • Six Transmembrane Epithelial Antigen Of The Prostate 2 2 3
  • Protein Up-Regulated In Metastatic Prostate Cancer 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 2 3 4
  • SixTransMembrane Protein Of Prostate 1 3 4
  • Prostate Cancer Associated Protein 1 2 3
  • Prostate Cancer-Associated Protein 1 3 4
  • PUMPCn 3 4
  • IPCA1 3 6
  • Six Transmembrane Epithelial Antigen Of Prostate 2 3
  • Protein Upregulated In Metastatic Prostate Cancer 3
  • Metalloreductase STEAP2 3
  • EC 1.16.1.- 4
  • EC 1.16.1 63
  • STMP 3

External Ids for STEAP2 Gene

Previous HGNC Symbols for STEAP2 Gene


Previous GeneCards Identifiers for STEAP2 Gene

  • GC07U990362
  • GC07P088377
  • GC07P089439
  • GC07P089453
  • GC07P089485
  • GC07P089678
  • GC07P089796
  • GC07P084453

Summaries for STEAP2 Gene

Entrez Gene Summary for STEAP2 Gene

  • This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP2 Gene

STEAP2 (STEAP Family Member 2, Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP2 include prostate cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include transporter activity and oxidoreductase activity. An important paralog of this gene is STEAP1.

UniProtKB/Swiss-Prot for STEAP2 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP2 Gene

Genomics for STEAP2 Gene

Regulatory Elements for STEAP2 Gene

Genomic Location for STEAP2 Gene

90,167,590 bp from pter
90,238,137 bp from pter
70,548 bases
Plus strand

Genomic View for STEAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STEAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP2 Gene

Proteins for STEAP2 Gene

  • Protein details for STEAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloreductase STEAP2
    Protein Accession:
    Secondary Accessions:
    • A4D1F1
    • G5E9C6
    • Q6UXN6
    • Q6YPB1
    • Q8IUE7

    Protein attributes for STEAP2 Gene

    490 amino acids
    Molecular mass:
    56056 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STEAP2 Gene


neXtProt entry for STEAP2 Gene

Proteomics data for STEAP2 Gene at MOPED

Selected DME Specific Peptides for STEAP2 Gene

Post-translational modifications for STEAP2 Gene

  • Ubiquitination at Lys64
  • Modification sites at PhosphoSitePlus

Domains for STEAP2 Gene

Protein Domains for STEAP2 Gene

Suggested Antigen Peptide Sequences for STEAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NFT2
  • Contains 1 ferric oxidoreductase domain.
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP2: view

No data available for Gene Families for STEAP2 Gene

Function for STEAP2 Gene

Molecular function for STEAP2 Gene

UniProtKB/Swiss-Prot Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP2 Gene

Gene Ontology (GO) - Molecular Function for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IDA 12095985
GO:0008823 cupric reductase activity IBA --
GO:0046872 metal ion binding IEA --
GO:0052851 ferric-chelate reductase (NADPH) activity IBA --
genes like me logo Genes that share ontologies with STEAP2: view

Animal Model Products

CRISPR Products

miRNA for STEAP2 Gene

miRTarBase miRNAs that target STEAP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STEAP2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for STEAP2 Gene

Localization for STEAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP2 Gene

Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for STEAP2 Gene COMPARTMENTS Subcellular localization image for STEAP2 gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IDA 12095985
GO:0005829 cytosol IDA 12095985
GO:0005886 plasma membrane IDA 12095985
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with STEAP2: view

Pathways for STEAP2 Gene

genes like me logo Genes that share pathways with STEAP2: view

Pathways by source for STEAP2 Gene

Interacting Proteins for STEAP2 Gene

Gene Ontology (GO) - Biological Process for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport IDA 12095985
GO:0006897 endocytosis IDA 12095985
GO:0009725 response to hormone IDA 12095985
GO:0015677 copper ion import IBA --
GO:0045055 regulated secretory pathway IDA 12095985
genes like me logo Genes that share ontologies with STEAP2: view

Compounds for STEAP2 Gene

(3) HMDB Compounds for STEAP2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1H-Purin-6-amine flavin dinucleotide
  • (protoporphyrinato)iron
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
genes like me logo Genes that share compounds with STEAP2: view

Transcripts for STEAP2 Gene

Unigene Clusters for STEAP2 Gene

STEAP family member 2, metalloreductase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STEAP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -

Relevant External Links for STEAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STEAP2 Gene

mRNA expression in normal human tissues for STEAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP2 Gene

This gene is overexpressed in Prostate (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STEAP2 Gene

SOURCE GeneReport for Unigene cluster for STEAP2 Gene Hs.489051

mRNA Expression by UniProt/SwissProt for STEAP2 Gene

Tissue specificity: Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
genes like me logo Genes that share expressions with STEAP2: view

In Situ Assay Products

Orthologs for STEAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STEAP2 35
  • 99.47 (n)
  • 99.32 (a)
  • 99 (a)
(Bos Taurus)
Mammalia STEAP2 35
  • 93.33 (n)
  • 97.55 (a)
  • 98 (a)
(Canis familiaris)
Mammalia STEAP2 35
  • 93.2 (n)
  • 97.55 (a)
  • 95 (a)
(Mus musculus)
Mammalia Steap2 35
  • 86.3 (n)
  • 96.73 (a)
Steap2 16
Steap2 36
  • 97 (a)
(Monodelphis domestica)
Mammalia STEAP2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia STEAP2 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Steap2 35
  • 86.5 (n)
  • 96.11 (a)
(Gallus gallus)
Aves STEAP2 35
  • 80.3 (n)
  • 89.16 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia STEAP2 36
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8813 35
tropical clawed frog
(Silurana tropicalis)
Amphibia steap2 35
  • 75.55 (n)
  • 83.81 (a)
(Danio rerio)
Actinopterygii steap2 35
  • 65.78 (n)
  • 73.82 (a)
steap2 36
  • 73 (a)
Species with no ortholog for STEAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP2 Gene

Gene Tree for STEAP2 (if available)
Gene Tree for STEAP2 (if available)

Paralogs for STEAP2 Gene

Paralogs for STEAP2 Gene

Selected SIMAP similar genes for STEAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STEAP2: view

Variants for STEAP2 Gene

Sequence variations from dbSNP and Humsavar for STEAP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs110360 -- 90,227,294(+) TACCT(C/T)GCAGG reference, synonymous-codon
rs183168 -- 90,229,587(+) TTGGA(C/T)TCCAG intron-variant
rs194507 -- 90,214,246(+) tgagg(G/T)tcagc intron-variant
rs194508 -- 90,214,992(+) catgt(A/G)tatac intron-variant
rs194509 -- 90,215,459(+) TATCA(A/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STEAP2 Gene

Variant ID Type Subtype PubMed ID
esv2752188 CNV Gain 17911159
nsv464626 CNV Gain 19166990
nsv888709 CNV Gain 21882294
nsv515997 CNV Gain+Loss 19592680
dgv2117e1 CNV Complex 17122850
nsv508465 CNV Loss 20534489
esv24241 CNV Loss 19812545
nsv888725 CNV Loss 21882294

Relevant External Links for STEAP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP2 Gene

Disorders for STEAP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for STEAP2 Gene including...

Search for STEAP2 Gene in MalaCards »

Relevant External Links for STEAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with STEAP2: view

No data available for UniProtKB/Swiss-Prot for STEAP2 Gene

Publications for STEAP2 Gene

  1. Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer. (PMID: 12095985) Korkmaz K.S. … Saatcioglu F. (J. Biol. Chem. 2002) 2 3 4
  2. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. (PMID: 12429817) Porkka K.P. … Visakorpi T. (Lab. Invest. 2002) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The Steap proteins are metalloreductases. (PMID: 16609065) Ohgami R.S. … Fleming M.D. (Blood 2006) 3 4
  5. Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. (PMID: 10613842) Walker M.G. … Klingler T. (Genome Res. 1999) 2 3

Products for STEAP2 Gene

Sources for STEAP2 Gene

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