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STEAP2 Gene

protein-coding   GIFtS: 59
GCID: GC07P089796

STEAP Family Member 2, Metalloreductase

(Previous names: prostate cancer associated protein 1, six transmembrane...)
(Previous symbol: PCANAP1)
  See STEAP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STEAP Family Member 2, Metalloreductase1 2     PUMPCn2 3
PCANAP11 2 3 5     IPCA12 5
STAMP12 3 5     STMP2
Prostate Cancer Associated Protein 11 2     Metalloreductase STEAP22
Six Transmembrane Epithelial Antigen Of The Prostate 21 2     Protein Upregulated In Metastatic Prostate Cancer2
Prostate Cancer-Associated Protein 12 3     Six Transmembrane Epithelial Antigen Of Prostate 22
Protein Up-Regulated In Metastatic Prostate Cancer2 3     EC 1.16.1.-3
Six-Transmembrane Epithelial Antigen Of Prostate 22 3     EC 1.16.18
SixTransMembrane Protein Of Prostate 12 3     

External Ids:    HGNC: 178851   Entrez Gene: 2617292   Ensembl: ENSG000001572147   OMIM: 6050945   UniProtKB: Q8NFT23   

Export aliases for STEAP2 gene to outside databases

Previous GC identifers: GC07U990362 GC07P088377 GC07P089439 GC07P089453 GC07P089485 GC07P089678 GC07P084453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STEAP2 Gene:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi
complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in
mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and
copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer
progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for STEAP2 Gene:
STEAP2 (STEAP family member 2, metalloreductase) is a protein-coding gene. Diseases associated with STEAP2 include prostate cancer. GO annotations related to this gene include oxidoreductase activity and transporter activity. An important paralog of this gene is STEAP1B.

UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+)
as acceptor (By similarity)

Gene Wiki entry for STEAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STEAP2 gene promoter:
         CHOP-10   HNF-4alpha1   RSRFC4   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STEAP2 promoter sequence
   Search Chromatin IP Primers for STEAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STEAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.13   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21.13

STEAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P089796:  view genomic region     (about GC identifiers)

Start:
89,796,904 bp from pter      End:
89,867,451 bp from pter
Size:
70,548 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 89,171,774-89,197,769     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2 (See protein sequence)
Recommended Name: Metalloreductase STEAP2  
Size: 490 amino acids; 56056 Da
Cofactor: FAD (By similarity)
Secondary accessions: A4D1F1 G5E9C6 Q6UXN6 Q6YPB1 Q8IUE7
Alternative splicing: 3 isoforms:  Q8NFT2-1   Q8NFT2-2   Q8NFT2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STEAP2: NX_Q8NFT2

Explore proteomics data for STEAP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for STEAP2 (Q8NFT2)
     GTKYRRFP  NQYPESNAEYLA 


    See STEAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035755.1  NP_001035756.1  NP_001231873.1  NP_001231874.1  NP_001231875.1  NP_694544.2  

    ENSEMBL proteins: 
     ENSP00000401783   ENSP00000287908   ENSP00000378123   ENSP00000378120   ENSP00000378128  
     ENSP00000415931   ENSP00000384191   ENSP00000378125   ENSP00000378119  
    Reactome Protein details: Q8NFT2

    STEAP2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for STEAP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013130 Fe3_Rdtase_TM_dom
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFT2

    ProtoNet protein and cluster: Q8NFT2

    UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
    Similarity: Belongs to the STEAP family
    Similarity: Contains 1 ferric oxidoreductase domain


    Find genes that share domains with STEAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STEA2_HUMAN, Q8NFT2
    Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+)
    as acceptor (By similarity)

         Enzyme Numbers (IUBMB): EC 1.16.1.-1 EC 1.16.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IDA12095985
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with STEAP2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Steap2 (no phenotypes)

    Find genes that share phenotypes with STEAP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Steap2tm1Lex for STEAP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STEAP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STEAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STEAP2

    miRNA
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    miRTarBase miRNAs that target STEAP2:
    hsa-mir-940 (MIRT036587), hsa-mir-197-3p (MIRT048078), hsa-mir-19b-3p (MIRT031189)

    Block miRNA regulation of human, mouse, rat STEAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STEAP2 (see all 41):
    hsa-miR-562 hsa-miR-607 hsa-miR-200a hsa-miR-3921 hsa-miR-29b-1* hsa-miR-141 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STEA2_HUMAN, Q8NFT2: Endosome membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    golgi apparatus5
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA12095985
    GO:0005829cytosol IDA12095985
    GO:0005886plasma membrane IDA12095985
    GO:0010008endosome membrane IEA--
    GO:0030140trans-Golgi network transport vesicle IDA12095985

    Find genes that share ontologies with STEAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STEAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Transferrin endocytosis and recycling0.74
    Iron uptake and transport0.70
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with STEAP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for STEAP2
        Transferrin endocytosis and recycling


    1 Kegg Pathway  (Kegg details for STEAP2):
        Mineral absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STEAP2
    Interactions:

        Search GeneGlobe Interaction Network for STEAP2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for STEAP2 (ENSP000002879084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    TARSENSP000002651124STRING: ENSP00000265112
    TARS2ENSP000003580604STRING: ENSP00000358060
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0006893Golgi to plasma membrane transport IDA12095985
    GO:0006897endocytosis IDA12095985
    GO:0009725response to hormone IDA12095985
    GO:0045055regulated secretory pathway IDA12095985

    Find genes that share ontologies with STEAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STEAP2 (STEA2)

    3 HMDB Compounds for STEAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STEAP2 gene (6 alternative transcripts): 
    NM_001040665.1  NM_001040666.1  NM_001244944.1  NM_001244945.1  NM_001244946.1  NM_152999.3  

    Unigene Cluster for STEAP2:

    STEAP family member 2, metalloreductase
    Hs.489051  [show with all ESTs]
    Unigene Representative Sequence: NM_001244944
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428074 ENST00000287908(uc003uka.3 uc010len.3 uc003ujz.3)
    ENST00000394626(uc003ukc.3) ENST00000394622(uc003ukb.3) ENST00000394632
    ENST00000426158 ENST00000402625 ENST00000394629(uc003ukd.3) ENST00000482369
    ENST00000394621(uc003ujy.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STEAP2 (see all 41):
    hsa-miR-562 hsa-miR-607 hsa-miR-200a hsa-miR-3921 hsa-miR-29b-1* hsa-miR-141 hsa-miR-124 hsa-miR-506
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      QuantiTect SYBR Green Assays in human, mouse, rat STEAP2
      QuantiFast Probe-based Assays in human, mouse, rat STEAP2

    Additional mRNA sequence: 

    AF455138.1 AF526382.1 AK026813.1 AK092666.1 AK094568.1 AK315043.1 AY008443.1 AY008444.1 
    AY358267.1 DQ656061.2 DQ656062.2 

    15 DOTS entries:

    DT.445518  DT.91938633  DT.100879339  DT.444302  DT.121056875  DT.121643431  DT.100030430  DT.100675602 
    DT.40288266  DT.92410567  DT.121056878  DT.121056903  DT.424631  DT.121056891  DT.121056897 

    Selected AceView cDNA sequences (see all 201):

    AW009886 AY358267 BM273289 BU738820 BM676454 AF109298 CD677221 BU620510 
    CA448283 W32085 BU630130 BF809488 AI016724 BI962940 BF509742 BF807159 
    BF809491 AI342468 BM968260 AI051210 BX641442 AW368012 W32120 BF809492 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STEAP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                                                                -                     
    SP2:                          -     -     -                                         -                     
    SP3:                    -           -     -                                   -     -                     
    SP4:                          -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for STEAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STEAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STEAP2 Expression
    About this image


    STEAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
    STEAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STEAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489051

    UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
    Tissue specificity: Expressed at high levels in prostate and at significantly lower levels in heart, brain,
    kidney, pancreas, and ovary

        Custom PCR Arrays for STEAP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STEAP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Steap21 , 5 six transmembrane epithelial antigen of prostate 21, 5 86.3(n)1
    96.73(a)1
      5 (3.18 cM)5
    740511  NM_028734.51  NP_083010.21 
     56659545 
    chicken
    (Gallus gallus)
    Aves STEAP21 STEAP family member 2, metalloreductase 80.3(n)
    89.16(a)
      420541  XM_418643.3  XP_418643.1 
    lizard
    (Anolis carolinensis)
    Reptilia STEAP26
    STEAP family member 2, metalloreductase
    86(a)
    1 ↔ 1
    6(20313651-20327945)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88132 Xenopus laevis transcribed sequence with weak similarity more 79.43(n)    AW159609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii steap21 six transmembrane epithelial antigen of the prostate more 65.78(n)
    73.82(a)
      100151287  XM_001921150.2  XP_001921185.1 


    ENSEMBL Gene Tree for STEAP2 (if available)
    TreeFam Gene Tree for STEAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STEAP2 gene
    STEAP1B2  STEAP42  STEAP12  STEAP32  
    6 SIMAP similar genes for STEAP2 using alignment to 5 protein entries:     STEA2_HUMAN (see all proteins):
    LOC392745    STEAP1    MGC87042    STEAP3    STEAP1B    STEAP4

    Find genes that share paralogs with STEAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STEAP2 (see all 547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1945001,2
    C,F,H--89839239(+) TCATAC/TTCTGC 5 -- us2k1 tfbs36Minor allele frequency- T:0.01NS EA NA 718
    rs178621231,2
    C,F,H--89839454(+) AGGAAA/CAGGGA 5 -- us2k1 trp310Minor allele frequency- C:0.39NS EA WA NA 778
    rs178686321,2
    H--89839569(+) TTATGG/ATTATA 5 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 418
    rs1893562651,2
    --89839605(+) AATATA/CCCCGT 5 -- us2k10--------
    rs1179560181,2
    C,F--89839852(+) TTCCAC/TACCCT 5 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1443351661,2
    --89839953(+) AGGATG/TTATTT 5 -- us2k10--------
    rs1945011,2
    C,F,A,H--89839973(+) CATTTG/ACAAAG 5 -- us2k128Minor allele frequency- A:0.42NA EA NS WA CSA 2762
    rs352030101,2
    C--89840003(+) ACAAA-/GGGGAA 5 -- us2k10--------
    rs2004969251,2
    C--89840003(-) TTCCCC/TTTTGT 5 -- us2k10--------
    rs102672381,2
    C,H--89840021(+) TGCCCC/AAGTGA 5 -- us2k15Minor allele frequency- A:0.00NS EA NA 414

    HapMap Linkage Disequilibrium report for STEAP2 (89796904 - 89867451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for STEAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv888725CNV Loss21882294
    nsv508465CNV Loss20534489
    esv24241CNV Loss19812545
    esv2752188CNV Gain17911159
    nsv464626CNV Gain19166990
    nsv888709CNV Gain21882294
    nsv515997CNV Gain+Loss19592680
    dgv2117e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STEAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for STEAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605094    OMIM disorders: --

    1 disease for STEAP2:    
    About MalaCards
    prostate cancer


    Find genes that share disorders with STEAP2           About GenesLikeMe

    Genetic Association Database (GAD): STEAP2
    Human Genome Epidemiology (HuGE) Navigator: STEAP2 (1 document)

    Export disorders for STEAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STEAP2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with STEAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer. (PubMed id 12095985)1, 2, 3 Korkmaz K.S....Saatcioglu F. (J. Biol. Chem. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The Steap proteins are metalloreductases. (PubMed id 16609065)1, 2 Ohgami R.S.... Fleming M.D. (Blood 2006)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. (PubMed id 12429817)1, 2 Porkka K.P.... Visakorpi T. (Lab. Invest. 2002)
    6. Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. (PubMed id 10613842)1, 3 Walker M.G.... Klingler T. (Genome Res. 1999)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 261729 HGNC: 17885 AceView: STEAP2 Ensembl:ENSG00000157214 euGenes: HUgn261729
    ECgene: STEAP2 Kegg: 261729 H-InvDB: STEAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STEAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STEAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STEAP2 gene:
    Search GeneIP for patents involving STEAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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