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Aliases for STEAP2 Gene

Aliases for STEAP2 Gene

  • STEAP2 Metalloreductase 2 3 5
  • Six Transmembrane Epithelial Antigen Of The Prostate 2 2 3
  • Protein Up-Regulated In Metastatic Prostate Cancer 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 2 3 4
  • STEAP Family Member 2, Metalloreductase 2 3
  • SixTransMembrane Protein Of Prostate 1 3 4
  • Prostate Cancer Associated Protein 1 2 3
  • Prostate Cancer-Associated Protein 1 3 4
  • PCANAP1 3 4
  • PUMPCn 3 4
  • STAMP1 3 4
  • Six Transmembrane Epithelial Antigen Of Prostate 2 3
  • Protein Upregulated In Metastatic Prostate Cancer 3
  • EC 1.16.1.- 4
  • EC 1.16.1 63
  • IPCA1 3
  • STMP 3

External Ids for STEAP2 Gene

Previous HGNC Symbols for STEAP2 Gene

  • PCANAP1

Previous GeneCards Identifiers for STEAP2 Gene

  • GC07U990362
  • GC07P088377
  • GC07P089439
  • GC07P089453
  • GC07P089485
  • GC07P089678
  • GC07P089796
  • GC07P084453

Summaries for STEAP2 Gene

Entrez Gene Summary for STEAP2 Gene

  • This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP2 Gene

STEAP2 (STEAP2 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP2 include prostate cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. GO annotations related to this gene include transporter activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP1.

UniProtKB/Swiss-Prot for STEAP2 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP2 Gene

Genomics for STEAP2 Gene

Regulatory Elements for STEAP2 Gene

Genomic Location for STEAP2 Gene

Chromosome:
7
Start:
90,167,590 bp from pter
End:
90,238,137 bp from pter
Size:
70,548 bases
Orientation:
Plus strand

Genomic View for STEAP2 Gene

Genes around STEAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP2 Gene

Proteins for STEAP2 Gene

  • Protein details for STEAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFT2-STEA2_HUMAN
    Recommended name:
    Metalloreductase STEAP2
    Protein Accession:
    Q8NFT2
    Secondary Accessions:
    • A4D1F1
    • G5E9C6
    • Q6UXN6
    • Q6YPB1
    • Q8IUE7

    Protein attributes for STEAP2 Gene

    Size:
    490 amino acids
    Molecular mass:
    56056 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STEAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP2 Gene

Proteomics data for STEAP2 Gene at MOPED

Selected DME Specific Peptides for STEAP2 Gene

Post-translational modifications for STEAP2 Gene

  • Ubiquitination at Lys 64
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for STEAP2 Gene

Protein Domains for STEAP2 Gene

Suggested Antigen Peptide Sequences for STEAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFT2

UniProtKB/Swiss-Prot:

STEA2_HUMAN :
  • Contains 1 ferric oxidoreductase domain.
  • Belongs to the STEAP family.
Domain:
  • Contains 1 ferric oxidoreductase domain.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP2: view

No data available for Gene Families for STEAP2 Gene

Function for STEAP2 Gene

Molecular function for STEAP2 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP2 Gene

Phenotypes for STEAP2 Gene

genes like me logo Genes that share phenotypes with STEAP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STEAP2

miRNA for STEAP2 Gene

miRTarBase miRNAs that target STEAP2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STEAP2 Gene

Localization for STEAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP2 Gene

Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STEAP2 Gene COMPARTMENTS Subcellular localization image for STEAP2 gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 12095985
GO:0005829 cytosol IDA 12095985
GO:0010008 endosome membrane IEA --
GO:0030140 trans-Golgi network transport vesicle IDA 12095985
genes like me logo Genes that share ontologies with STEAP2: view

Pathways & Interactions for STEAP2 Gene

genes like me logo Genes that share pathways with STEAP2: view

Pathways by source for STEAP2 Gene

Interacting Proteins for STEAP2 Gene

Gene Ontology (GO) - Biological Process for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport IDA 12095985
GO:0006897 endocytosis IDA 12095985
GO:0015677 copper ion import IEA,IBA --
genes like me logo Genes that share ontologies with STEAP2: view

No data available for SIGNOR curated interactions for STEAP2 Gene

Drugs & Compounds for STEAP2 Gene

(3) Drugs for STEAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP2: view

Transcripts for STEAP2 Gene

Unigene Clusters for STEAP2 Gene

STEAP family member 2, metalloreductase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for STEAP2 Gene

GeneLoc Exon Structure for
STEAP2
ECgene alternative splicing isoforms for
STEAP2

Expression for STEAP2 Gene

mRNA expression in normal human tissues for STEAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP2 Gene

This gene is overexpressed in Prostate (x5.9).

Protein differential expression in normal tissues from HIPED for STEAP2 Gene

This gene is overexpressed in Prostate (36.4), Breast (15.8), and Fetal Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STEAP2 Gene



SOURCE GeneReport for Unigene cluster for STEAP2 Gene Hs.489051

mRNA Expression by UniProt/SwissProt for STEAP2 Gene

Q8NFT2-STEA2_HUMAN
Tissue specificity: Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
genes like me logo Genes that share expression patterns with STEAP2: view

Protein tissue co-expression partners for STEAP2 Gene

Primer Products

In Situ Assay Products

Orthologs for STEAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STEAP2 35
  • 93.33 (n)
  • 97.55 (a)
STEAP2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STEAP2 35
  • 93.2 (n)
  • 97.55 (a)
STEAP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Steap2 35
  • 86.3 (n)
  • 96.73 (a)
Steap2 16
Steap2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STEAP2 35
  • 99.47 (n)
  • 99.32 (a)
STEAP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Steap2 35
  • 86.5 (n)
  • 96.11 (a)
oppossum
(Monodelphis domestica)
Mammalia STEAP2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STEAP2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves STEAP2 35
  • 80.3 (n)
  • 89.16 (a)
STEAP2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STEAP2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia steap2 35
  • 75.55 (n)
  • 83.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8813 35
zebrafish
(Danio rerio)
Actinopterygii steap2 35
  • 65.78 (n)
  • 73.82 (a)
steap2 36
  • 73 (a)
OneToOne
Species with no ortholog for STEAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP2 Gene

ENSEMBL:
Gene Tree for STEAP2 (if available)
TreeFam:
Gene Tree for STEAP2 (if available)

Paralogs for STEAP2 Gene

Paralogs for STEAP2 Gene

(6) SIMAP similar genes for STEAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STEAP2: view

Variants for STEAP2 Gene

Sequence variations from dbSNP and Humsavar for STEAP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs13228098 - 90,227,119(+) GAGAG(A/G)GCCAG reference, missense
rs194524 - 90,232,518(+) AAGCC(A/G)AAAGC intron-variant, reference, missense
rs194520 - 90,225,132(+) AACTT(G/T)TTTAC reference, missense
rs17863046 - 90,225,200(+) GTGGA(G/T)ATTTT reference, missense
rs194525 - 90,232,576(+) GGTAT(A/G/T)GGAGG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STEAP2 Gene

Variant ID Type Subtype PubMed ID
esv2752188 CNV Gain 17911159
nsv464626 CNV Gain 19166990
nsv888709 CNV Gain 21882294
nsv515997 CNV Gain+Loss 19592680
dgv2117e1 CNV Complex 17122850
nsv508465 CNV Loss 20534489
esv24241 CNV Loss 19812545
nsv888725 CNV Loss 21882294

Variation tolerance for STEAP2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.44; 97.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STEAP2 Gene

HapMap Linkage Disequilibrium report
STEAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP2 Gene

Disorders for STEAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STEAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STEAP2

Genetic Association Database (GAD)
STEAP2
Human Genome Epidemiology (HuGE) Navigator
STEAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STEAP2
genes like me logo Genes that share disorders with STEAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STEAP2 Gene

Publications for STEAP2 Gene

  1. Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer. (PMID: 12095985) Korkmaz K.S. … Saatcioglu F. (J. Biol. Chem. 2002) 2 3 4 67
  2. Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. (PMID: 10613842) Walker M.G. … Klingler T. (Genome Res. 1999) 2 3
  3. A role for STEAP2 in prostate cancer progression. (PMID: 25248617) Whiteland H. … Doak S.H. (Clin. Exp. Metastasis 2014) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer. (PMID: 20587517) Wang L. … Saatcioglu F. (Cancer Res. 2010) 3

Products for STEAP2 Gene

Sources for STEAP2 Gene

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