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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STEAP2 Gene

protein-coding   GIFtS: 53
GCID: GC07P089796

STEAP family member 2, metalloreductase

(Previous names: prostate cancer associated protein 1, six transmembrane...)
(Previous symbol: PCANAP1)
 Explore 3 diseases affiliated with
STEAP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STEAP2    

Aliases
for STEAP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
STEAP Family Member 2, Metalloreductase1 2     SixTransMembrane Protein Of Prostate 12 3
PCANAP11 2 3 5     PUMPCn2 3
STAMP11 2 3 5     IPCA12 5
STMP1 2     IPCA-11
Prostate Cancer Associated Protein 11 2     Metalloreductase STEAP22
Six Transmembrane Epithelial Antigen Of The Prostate 21 2     Protein Upregulated In Metastatic Prostate Cancer2
Prostate Cancer-Associated Protein 12 3     Six Transmembrane Epithelial Antigen Of Prostate 22
Protein Up-Regulated In Metastatic Prostate Cancer2 3     EC 1.16.1.-3
Six-Transmembrane Epithelial Antigen Of Prostate 22 3     EC 1.16.18

External Ids:    HGNC: 178851   Entrez Gene: 2617292   Ensembl: ENSG000001572147   OMIM: 6050945   UniProtKB: Q8NFT23   

Export aliases for STEAP2 gene to outside databases

Previous GC identifers: GC07U990362 GC07P088377 GC07P089439 GC07P089453 GC07P089485 GC07P089678 GC07P084453


Summaries
for STEAP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STEAP2:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi
complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse
has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in
vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression.
Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as
acceptor (By similarity)

Gene Wiki entry for STEAP2


Genomic Views
for STEAP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STEAP2 gene promoter:
         CHOP-10   HNF-4alpha1   RSRFC4   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STEAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STEAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.13   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21.13

STEAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P089796:  view genomic region     (about GC identifiers)

Start:
 89,796,904 bp from pter      End:
 89,870,091 bp from pter
Size:
 73,188 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 89,171,774-89,197,769     

Proteins
for STEAP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2 (See protein sequence)
Recommended Name: Metalloreductase STEAP2  
Size: 490 amino acids; 56056 Da
Cofactor: FAD (By similarity)
Subcellular location: Endosome membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass
membrane protein
Secondary accessions: A4D1F1 G5E9C6 Q6UXN6 Q6YPB1 Q8IUE7
Alternative splicing: 3 isoforms:  Q8NFT2-1   Q8NFT2-2   Q8NFT2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STEAP2: NX_Q8NFT2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NFT2

    • 2 DME Specific Peptides for STEAP2 (Q8NFT2)
     GTKYRRFP  NQYPESNAEYLA 

    STEAP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001035755.1  NP_001035756.1  NP_001231873.1  NP_001231874.1  NP_001231875.1  NP_694544.2  

    ENSEMBL proteins: 
     ENSP00000401783   ENSP00000287908   ENSP00000378123   ENSP00000378120   ENSP00000378128  
     ENSP00000378121   ENSP00000415931   ENSP00000384191   ENSP00000378125   ENSP00000378119  

    Human Recombinant Protein Products: 
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    Uscn Proteins for STEAP2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA12095985
    GO:0005829cytosol IDA12095985
    GO:0005886plasma membrane IDA12095985
    GO:0010008endosome membrane IEA--
    GO:0016021integral to membrane ----


    STEAP2 for ontologies           About GeneDecksing



    STEAP2 Antibody Products: 
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    Uscn Antibodies for STEAP2
    ThermoFisher Antibody for STEAP2

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    Uscn ELISAs and CLIAs for STEAP2

    Protein Domains /
    Families
    for STEAP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STEAP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004455 NADP_OxRdtase_F420
     IPR013130 Fe3_Rdtase_TM_dom
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFT2

    ProtoNet protein and cluster: Q8NFT2

    UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
    Similarity: Belongs to the STEAP family
    Similarity: Contains 1 ferric oxidoreductase domain


    Function
    for STEAP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
    Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as
    acceptor (By similarity)

    Enzyme Numbers (IUBMB): EC 1.16.1.-1 EC 1.16.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP2
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP2 (see all 41):
    hsa-miR-562 hsa-miR-607 hsa-miR-200a hsa-miR-3921 hsa-miR-29b-1* hsa-miR-141 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STEAP2 (see all 7)
    OriGene shRNA RFP: STEAP2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STEAP2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP2 (see all 7)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for STEAP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0005215transporter activity IDA12095985
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--


    STEAP2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Steap2tm1Lex for STEAP2
         1 MGI phenotypic allele for Steap2 (no phenotypes)

    STEAP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STEAP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for STEAP2):
        Mineral absorption


    STEAP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STEAP2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for STEAP2 (ENSP000002879084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0006893Golgi to plasma membrane transport IDA12095985
    GO:0006897endocytosis IDA12095985
    GO:0009725response to hormone stimulus IDA12095985
    GO:0022900electron transport chain IEA--


    STEAP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STEAP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STEAP2

    3 HMDB Compounds for STEAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Search CenterWatch for drugs/clinical trials and news about STEAP2 / STEA2 

    Transcripts
    for STEAP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STEAP2 gene (6 alternative transcripts): 
    NM_001040665.1  NM_001040666.1  NM_001244944.1  NM_001244945.1  NM_001244946.1  NM_152999.3  

    Unigene Cluster for STEAP2:

    STEAP family member 2, metalloreductase
    Hs.489051  [show with all ESTs]
    Unigene Representative Sequence: NM_001244944
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428074 ENST00000287908(uc003uka.3 uc010len.3 uc003ujz.3)
    ENST00000394626(uc003ukc.3) ENST00000394622(uc003ukb.3) ENST00000394632
    ENST00000394624 ENST00000426158 ENST00000402625 ENST00000394629(uc003ukd.3)
    ENST00000482369 ENST00000394621(uc003ujy.2)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP2
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP2 (see all 41):
    hsa-miR-562 hsa-miR-607 hsa-miR-200a hsa-miR-3921 hsa-miR-29b-1* hsa-miR-141 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STEAP2 (see all 7)
    OriGene shRNA RFP: STEAP2
    OriGene siRNA: STEAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): STEAP2 (NM_152999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP2

    Additional cDNA sequence: 

    AF455138.1 AF526382.1 AK026813.1 AK092666.1 AK094568.1 AK315043.1 AY008443.1 AY008444.1 
    AY358267.1 DQ656061.2 DQ656062.2 

    15 DOTS entries:

    DT.445518  DT.91938633  DT.100879339  DT.444302  DT.121056875  DT.121643431  DT.100030430  DT.100675602 
    DT.40288266  DT.92410567  DT.121056878  DT.121056903  DT.424631  DT.121056891  DT.121056897 

    24/201 AceView cDNA sequences (see all 201):

    BX641442 BF803283 BF509742 AY358267 AW368012 W32120 BF809492 BF809491 
    CA448283 CD677221 AI051210 BX641441 AI342468 AI016724 BF809485 BU630130 
    AF109298 BU620510 AW009886 BI962940 BM968260 BM676454 BU738820 BF807159 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for STEAP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                                                                                -                     
    SP2:                          -     -     -                                         -                     
    SP3:                    -           -     -                                   -     -                     
    SP4:                          -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for STEAP2

    Expression
    for STEAP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STEAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STEAP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See STEAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STEAP2

    SOURCE GeneReport for Unigene cluster: Hs.489051

    UniProtKB/Swiss-Prot: STEA2_HUMAN, Q8NFT2
    Tissue specificity: Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney,
    pancreas, and ovary

        SABiosciences Custom PCR Arrays for STEAP2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP2

    Orthologs
    for STEAP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for STEAP2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STEAP21 six transmembrane epithelial antigen of the prostate more 80.3(n)
    89.16(a)    		   420541  XM_418643.2  XP_418643.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STEAP26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 6(20322279-20327945)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.88132 Xenopus laevis transcribed sequence with weak similarity more 79.43(n)    AW159609.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii steap21 six transmembrane epithelial antigen of the prostate more 65.78(n)
    73.82(a)    		   100151287  XM_001921150.1  XP_001921185.1 


    ENSEMBL Gene Tree for STEAP2 (if available)
    TreeFam Gene Tree for STEAP2 (if available) 

    Paralogs
    for STEAP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STEAP2 gene
    STEAP1B2  STEAP42  STEAP12  STEAP32  
    6 SIMAP similar genes for STEAP2 using alignment to 5 protein entries:     STEA2_HUMAN (see all proteins):
    LOC392745    STEAP1    MGC87042    STEAP3    STEAP1B    STEAP4

    STEAP2 for paralogs           About GeneDecksing



    Genomic Variants
    for STEAP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/483 NCBI SNPs in STEAP2 are shown (see all 483)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1945001,2
    		C,F,H,--89839239(+) TCATAC/TTCTGC 5 -- us2k1 tfbs36Minor allele frequency- T:0.01NS EA NA 718
    rs178621231,2
    		C,F,H,--89839454(+) AGGAAA/CAGGGA 5 -- us2k1 trp310Minor allele frequency- C:0.39NS EA WA NA 778
    rs178686321,2
    		H--89839569(+) TTATGG/ATTATA 5 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 418
    rs1893562651,2
    		--89839605(+) AATATA/CCCCGT 5 -- us2k10--------
    rs1179560181,2
    		--89839852(+) TTCCAC/TACCCT 5 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1443351661,2
    		--89839953(+) AGGATG/TTATTT 5 -- us2k10--------
    rs1945011,2
    		C,F,A,H,--89839973(+) CATTTG/ACAAAG 5 -- us2k128Minor allele frequency- A:0.42NA EA NS WA CSA 2762
    rs352030101,2
    		C,--89840003(+) ACAAA-/GGGGAA 5 -- us2k10--------
    rs2004969251,2
    		C--89840003(-) TTCCCC/TTTTGT 5 -- us2k10--------
    rs102672381,2
    		C,H--89840021(+) TGCCCC/AAGTGA 5 -- us2k15Minor allele frequency- A:0.00NS EA NA 414

    HapMap Linkage Disequilibrium report for STEAP2 (89796904 - 89870091 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for STEAP2
         3 CNVs: 2704 8573 69996

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    Disorders / Diseases
    for STEAP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STEAP2 for disorders           About GeneDecksing

    OMIM gene information: 605094    OMIM disorders: --

    3 diseases for STEAP2:    About MalaCards
    prostate cancer    prostatitis    prostate cancer, progression of

    Human Genome Epidemiology (HuGE) Navigator: STEAP2 (1 document)

    Export disorders for STEAP2 gene to outside databases

    Publications
    for STEAP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STEAP2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with STEAP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer. (PubMed id 12095985)1, 2, 3 Korkmaz K.S....Saatcioglu F. (2002)
    2. The Steap proteins are metalloreductases. (PubMed id 16609065)1, 2 Ohgami R.S.... Fleming M.D. (2006)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. (PubMed id 12429817)1, 2 Porkka K.P.... Visakorpi T. (2002)
    5. Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. (PubMed id 10613842)1, 3 Walker M.G.... Klingler T. (1999)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. STAMP1 is both a proliferative and an antiapoptotic f actor in prostate cancer. (PubMed id 20587517)1 Wang L....Saatcioglu F. (2010)

    External Searches for STEAP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STEAP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 261729 HGNC: 17885 AceView: STEAP2 Ensembl:ENSG00000157214 euGenes: HUgn261729
    ECgene: STEAP2 Kegg: 261729 H-InvDB: STEAP2

    Other Databases showing STEAP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STEAP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STEAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STEAP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for STEAP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STEAP2 gene:
    Search GeneIP for patents involving STEAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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