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STEAP1B Gene

protein-coding   GIFtS: 32
GCID: GC07M022459

STEAP Family Member 1B

  Search for STEAP1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STEAP Family Member 1B1 2
STEAP Family Protein MGC870422

External Ids:    HGNC: 419071   Entrez Gene: 2562272   Ensembl: ENSG000001058897   UniProtKB: Q6NZ633   

Export aliases for STEAP1B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for STEAP1B Gene:
STEAP1B (STEAP family member 1B) is a protein-coding gene. An important paralog of this gene is STEAP2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for STEAP1B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for STEAP1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STEAP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

STEAP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP1B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M022459:  view genomic region     (about GC identifiers)

Start:
22,459,063 bp from pter      End:
22,672,544 bp from pter
Size:
213,482 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 22,510,236-22,590,992     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STEAL_HUMAN, Q6NZ63 (See protein sequence)
Recommended Name: STEAP family member 1B  
Size: 245 amino acids; 28815 Da

Explore the universe of human proteins at neXtProt for STEAP1B: NX_Q6NZ63

Explore proteomics data for STEAP1B at MOPED


See STEAP1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001157932.1  NP_997225.1  

ENSEMBL proteins: 
 ENSP00000385239   ENSP00000384370   ENSP00000416608   ENSP00000408954  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR013130 Fe3_Rdtase_TM_dom

Graphical View of Domain Structure for InterPro Entry Q6NZ63

ProtoNet protein and cluster: Q6NZ63

UniProtKB/Swiss-Prot: STEAL_HUMAN, Q6NZ63
Similarity: Belongs to the STEAP family


Find genes that share domains with STEAP1B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STEAP1B
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
STEAL_HUMAN, Q6NZ63: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with STEAP1B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STEAP1B
Interactions:

    Search GeneGlobe Interaction Network for STEAP1B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for STEAP1B (STEAL)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for STEAP1B gene (2 alternative transcripts): 
NM_001164460.1  NM_207342.2  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000406890(uc003svh.3) ENST00000404369(uc010kum.2) ENST00000483679
ENST00000424363 ENST00000439708
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22 AceView cDNA sequences:

BQ014710 CB160258 AI651530 BI551229 BG762026 AW204859 BM920324 AW071597 
BC066301 AW474994 BX506262 BU188383 CB143042 BG182296 BG186101 AW198084 
BQ014856 BG201954 BE183969 BM811413 AW129021 AW796185 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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STEAP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATAATCAAAT
STEAP1B Expression
About this image

STEAP1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

STEAP1B Protein Expression
    Custom PCR Arrays for STEAP1B
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for STEAP1B gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
54(a)
1 → many
2(21523765-21533990)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
53(a)
1 → many
6(20282895-20303132)
        Species with no ortholog for STEAP1B

ENSEMBL Gene Tree for STEAP1B (if available)
TreeFam Gene Tree for STEAP1B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for STEAP1B gene
STEAP22  STEAP42  STEAP12  STEAP32  
6 SIMAP similar genes for STEAP1B using alignment to 4 protein entries:     STEAL_HUMAN (see all proteins):
MGC87042    STEAP1    LOC392745    STEAP2    STEAP3    STEAP4

Find genes that share paralogs with STEAP1B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for STEAP1B (see all 1960)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1485519281,2
C--22458566(+) AATCAC/TTATCT 1 -- ds50010--------
rs1429166911,2
C--22458585(+) CCTCCC/TGGGAA 1 -- ds50010--------
rs1856017641,2
--22458615(+) GACAGA/GCTTGG 1 -- ds50010--------
rs1177223171,2
F--22458814(+) TTTTCT/CAAACA 1 -- ds50011Minor allele frequency- C:0.01NA 120
rs102360851,2
C,F,H--22458834(+) AATATC/GTCCCC 1 -- ds50018Minor allele frequency- G:0.05NS EA CSA WA 662
rs1904558691,2
--22458874(+) GCTTGC/TACCTG 1 -- ds50010--------
rs1506749881,2
--22458903(+) GCCAGC/GAAAGT 1 -- ds50010--------
rs1399864031,2
--22458955(+) GCGTTC/TCTCAG 1 -- ds50010--------
rs25288301,2
C,F,O,A,H--22459056(+) GATGCA/GAATTC 1 -- ds500127Minor allele frequency- N:0.00NS EA NA WA CSA 2568
rs1439456471,2
--22459117(+) TTTATA/GAACAC 1 -- ut310--------

HapMap Linkage Disequilibrium report for STEAP1B (22459063 - 22672544 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for STEAP1B:    About this table    
Variant IDTypeSubtypePubMed ID
esv1507352CNV Deletion17803354
esv2590646CNV Deletion19546169
esv1928956CNV Deletion18987734
esv991050CNV Deletion20482838
esv2665146CNV Deletion23128226
esv2667204CNV Deletion23128226
esv2734122CNV Deletion23290073
nsv5658CNV Loss18451855
nsv830923CNV Gain17160897
nsv7393OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for STEAP1B gene integrated from 10 sources:
(articles sorted by number of sources associating them with STEAP1B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1 Murea M....Freedman B.I. (Am. J. Nephrol. 2011)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 256227 HGNC: 41907 AceView: MGC87042 Ensembl:ENSG00000105889 euGenes: HUgn256227
ECgene: STEAP1B H-InvDB: STEAP1B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for STEAP1B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for STEAP1B gene:
Search GeneIP for patents involving STEAP1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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