STEAP1B Gene
protein-coding GIFtS: 34
GCID: GC07M022459
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STEAP family member 1B
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Aliases
for STEAP1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| STEAP Family Member 1B1 2 | | STEAP Family Protein MGC870422 |
Export aliases for STEAP1B gene to outside databases |
Summaries
for STEAP1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for STEAP1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for STEAP1B
Other transcription factors
Search SABiosciences Chromatin IP Primers for STEAP1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p15.3 Ensembl cytogenetic band: 7p15.3 HGNC cytogenetic band: 7p15.3STEAP1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M022459: view genomic region
(about GC identifiers)
Start:
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22,459,063 bp from pter |
End:
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22,672,544 bp from pter |
Size:
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213,482 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 22,510,236-22,590,992 |
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Proteins
for STEAP1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STEAL_HUMAN, Q6NZ63 (See
protein sequence)Recommended Name: STEAP family member 1B Size: 245 amino acids; 28815 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for STEAP1B: NX_Q6NZ63
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NZ63
STEAP1B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001157932.1 NP_997225.1
ENSEMBL proteins: ENSP00000385239 ENSP00000384370 ENSP00000416608 ENSP00000408954
Human Recombinant Protein Products for STEAP1B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
STEAP1B for ontologies About GeneDecksing
STEAP1B Antibody Products:
Assay Products for STEAP1B: |
Protein
Domains /
Families
for STEAP1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STEAP1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NZ63ProtoNet protein and cluster: Q6NZ63 UniProtKB/Swiss-Prot: STEAL_HUMAN, Q6NZ63Similarity: Belongs to the STEAP family |
Function
for STEAP1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP1B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for STEAP1B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STEAP1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1B |
|
Pathways & Interactions
for STEAP1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STEAP1B
|
Drugs & Compounds
for STEAP1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STEAP1B
Search CenterWatch for drugs/clinical trials and news about STEAP1B / STEAL
|
Transcripts
for STEAP1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STEAP1B gene (2 alternative transcripts): NM_001164460.1 NM_207342.2 Unigene Cluster for STEAP1B: STEAP family member 1B Hs.729825 [show with all ESTs]Unigene Representative Sequence: NM_0011644605 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000406890(uc003svh.3) ENST00000404369(uc010kum.2) ENST00000483679
ENST00000424363 ENST00000439708
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP1B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for STEAP1B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STEAP1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1B |
Additional cDNA sequence: AK308991.1 BC066301.1 5 DOTS entries: DT.102825920 DT.100728980 DT.91723326 DT.97858264 DT.442086 22 AceView cDNA sequences: BQ014710 CB160258 AW204859 BU188383 AI651530 AW071597 BG182296 AW474994 BI551229 BX506262 CB143042 BG762026 BC066301 BM920324 AW198084 BG186101 BQ014856 BG201954 BE183969 AW129021 BM811413 AW796185
GeneLoc Exon Structure
|
Expression
for STEAP1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STEAP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATCAAAT
About this image
Genevestigator expression for STEAP1B
SOURCE GeneReport for Unigene cluster: Hs.729825
SABiosciences Custom PCR Arrays for STEAP1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STEAP1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STEAP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1B |
Orthologs
for STEAP1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for STEAP1B gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
STEAP16 |
Uncharacterized protein |
56(a) |
1 → many |
2(21588182-21598413) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
52(a) |
1 → many |
6(20297925-20301959) |
ENSEMBL Gene Tree for STEAP1B (if available)
TreeFam Gene Tree for STEAP1B (if available) |
Paralogs
for STEAP1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STEAP1B gene
- STEAP22 STEAP42 STEAP12 STEAP32
6 SIMAP similar genes for STEAP1B using alignment to 4 protein entries: STEAL_HUMAN (see all proteins):MGC87042 STEAP1 LOC392745 STEAP2 STEAP3 STEAP4
STEAP1B for paralogs About GeneDecksing
|
Genomic Variants
for STEAP1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STEAP1B (22459063 - 22672544 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STEAP1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STEAP1B |
|
Disorders
/ Diseases
for STEAP1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STEAP1B for disorders About GeneDecksing
1  disease for STEAP1B: About MalaCardsprostatitis
Export disorders for STEAP1B gene to outside databases
|
Publications
for STEAP1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STEAP1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with STEAP1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1 Murea M....Freedman B.I. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for STEAP1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STEAP1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STEAP1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STEAP1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for STEAP1B gene:
Search GeneIP for patents involving STEAP1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STEAP1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STEAP1B | | | OriGene Protein Over-expression Lysate for STEAP1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STEAP1B | | OriGene 3'-UTR Clone for STEAP1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STEAP1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STEAP1B | | OriGene Custom Protein Services for STEAP1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STEAP1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STEAP1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP1B |
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| | | | Search Tocris compounds for STEAP1B |
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 | | | STEAP1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for STEAP1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1B |
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