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Aliases for STEAP1B Gene

Aliases for STEAP1B Gene

  • STEAP Family Member 1B 2 3 5

External Ids for STEAP1B Gene

Previous GeneCards Identifiers for STEAP1B Gene

  • GC07M022459

Summaries for STEAP1B Gene

GeneCards Summary for STEAP1B Gene

STEAP1B (STEAP Family Member 1B) is a Protein Coding gene. GO annotations related to this gene include cupric reductase activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP1B Gene

Genomics for STEAP1B Gene

Regulatory Elements for STEAP1B Gene

Enhancers for STEAP1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STEAP1B on UCSC Golden Path with GeneCards custom track

Genomic Location for STEAP1B Gene

Chromosome:
7
Start:
22,419,444 bp from pter
End:
22,632,925 bp from pter
Size:
213,482 bases
Orientation:
Minus strand

Genomic View for STEAP1B Gene

Genes around STEAP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP1B Gene

Proteins for STEAP1B Gene

  • Protein details for STEAP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZ63-STEAL_HUMAN
    Recommended name:
    STEAP family member 1B
    Protein Accession:
    Q6NZ63
    Secondary Accessions:
    • B5MCI2

    Protein attributes for STEAP1B Gene

    Size:
    245 amino acids
    Molecular mass:
    28815 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STEAP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP1B Gene

Proteomics data for STEAP1B Gene at MOPED

Post-translational modifications for STEAP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STEAP1B Gene

No data available for DME Specific Peptides for STEAP1B Gene

Domains & Families for STEAP1B Gene

Protein Domains for STEAP1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STEAP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NZ63

UniProtKB/Swiss-Prot:

STEAL_HUMAN :
  • Belongs to the STEAP family.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP1B: view

No data available for Gene Families for STEAP1B Gene

Function for STEAP1B Gene

Gene Ontology (GO) - Molecular Function for STEAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052851 NOT ferric-chelate reductase (NADPH) activity IBA --
genes like me logo Genes that share ontologies with STEAP1B: view

Phenotypes for STEAP1B Gene

genes like me logo Genes that share phenotypes with STEAP1B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STEAP1B Gene

Localization for STEAP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STEAP1B Gene COMPARTMENTS Subcellular localization image for STEAP1B gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for STEAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
genes like me logo Genes that share ontologies with STEAP1B: view

Pathways & Interactions for STEAP1B Gene

SuperPathways for STEAP1B Gene

No Data Available

Interacting Proteins for STEAP1B Gene

Gene Ontology (GO) - Biological Process for STEAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015677 NOT copper ion import IBA --
genes like me logo Genes that share ontologies with STEAP1B: view

No data available for Pathways by source and SIGNOR curated interactions for STEAP1B Gene

Drugs & Compounds for STEAP1B Gene

No Compound Related Data Available

Transcripts for STEAP1B Gene

mRNA/cDNA for STEAP1B Gene

Unigene Clusters for STEAP1B Gene

STEAP family member 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP1B Gene

No ASD Table

Relevant External Links for STEAP1B Gene

GeneLoc Exon Structure for
STEAP1B
ECgene alternative splicing isoforms for
STEAP1B

Expression for STEAP1B Gene

mRNA expression in normal human tissues for STEAP1B Gene

SOURCE GeneReport for Unigene cluster for STEAP1B Gene Hs.729825

genes like me logo Genes that share expression patterns with STEAP1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STEAP1B Gene

Orthologs for STEAP1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STEAP1B 35
  • 98.02 (n)
  • 95.74 (a)
STEAP1 36
  • 76 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Steap1 36
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
Species with no ortholog for STEAP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STEAP1B Gene

ENSEMBL:
Gene Tree for STEAP1B (if available)
TreeFam:
Gene Tree for STEAP1B (if available)

Paralogs for STEAP1B Gene

Paralogs for STEAP1B Gene

(6) SIMAP similar genes for STEAP1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STEAP1B: view

Variants for STEAP1B Gene

Sequence variations from dbSNP and Humsavar for STEAP1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7787814 - 22,494,837(+) TGTGA(C/T)GTCTT reference, missense
rs16881810 - 22,493,778(+) CTGTT(C/T)GCTGC reference, missense
rs16881812 - 22,493,367(+) ATCGC(A/C)TCATT reference, missense
rs16881817 - 22,492,641(+) CCAGT(A/G)TTGCC reference, missense
rs767871 -- 22,468,099(+) gcatt(C/G)tgtat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STEAP1B Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
esv2665146 CNV Deletion 23128226
nsv830923 CNV Gain 17160897
esv2590646 CNV Deletion 19546169
esv1928956 CNV Deletion 18987734
esv2667204 CNV Deletion 23128226
esv991050 CNV Deletion 20482838
esv2734122 CNV Deletion 23290073
esv1507352 CNV Deletion 17803354
nsv5658 CNV Loss 18451855

Variation tolerance for STEAP1B Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.66; 97.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STEAP1B Gene

HapMap Linkage Disequilibrium report
STEAP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP1B Gene

Disorders for STEAP1B Gene

Relevant External Links for STEAP1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STEAP1B

No disorders were found for STEAP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STEAP1B Gene

Publications for STEAP1B Gene

  1. Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms. (PMID: 25053991) Gomes I.M. … Maia C.J. (Genes Cancer 2014) 3 67
  2. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for STEAP1B Gene

Sources for STEAP1B Gene

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