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Aliases for STEAP1 Gene

Aliases for STEAP1 Gene

  • STEAP Family Member 1 2 3 5
  • Six Transmembrane Epithelial Antigen Of The Prostate 1 2 3
  • Six-Transmembrane Epithelial Antigen Of Prostate 1 3 4
  • STEAP1 Metalloreductase 2 3
  • PRSS24 3 4
  • STEAP 3 4
  • Six Transmembrane Epithelial Antigen Of The Prostate 2
  • Metalloreductase STEAP1 3
  • EC 1.16.1.- 4

External Ids for STEAP1 Gene

Previous HGNC Symbols for STEAP1 Gene


Previous GeneCards Identifiers for STEAP1 Gene

  • GC07P089430
  • GC07P089622
  • GC07P089779
  • GC07P084394

Summaries for STEAP1 Gene

Entrez Gene Summary for STEAP1 Gene

  • This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP1 Gene

STEAP1 (STEAP Family Member 1) is a Protein Coding gene. Diseases associated with STEAP1 include Suppression Of Tumorigenicity 12 and Ewing Sarcoma. Among its related pathways are Mineral absorption and Copper homeostasis. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and channel activity. An important paralog of this gene is STEAP1B.

UniProtKB/Swiss-Prot for STEAP1 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP1 Gene

Additional gene information for STEAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP1 Gene

Genomics for STEAP1 Gene

GeneHancer (GH) Regulatory Elements for STEAP1 Gene

Promoters and enhancers for STEAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I090153 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 468 2 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 STEAP1 STEAP2 STEAP2-AS1
GH07I090210 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 39.6 +57.3 57272 2.3 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 SP5 ZHX2 STEAP2 STEAP2-AS1 STEAP1 GC07P090219
GH07I090177 Enhancer 1.2 Ensembl ENCODE dbSUPER 49.3 +25.1 25072 3.2 ELF3 FOXA2 SMAD1 BMI1 BATF IRF4 ATF7 FOS IKZF2 RUNX3 STEAP1 GTPBP10 STEAP2 STEAP2-AS1
GH07I090345 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 26.8 +192.3 192349 2.7 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 GTPBP10 ENSG00000280440 PIR48694 STEAP1 STEAP2 ENSG00000234459 CLDN12
GH07I090173 Enhancer 1.1 FANTOM5 dbSUPER 48.5 +18.9 18898 0.3 ELF3 FOXA2 ARID4B RAD21 RARA YY1 ATF7 CREM IKZF2 RUNX3 STEAP1 STEAP2 STEAP2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STEAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STEAP1 gene promoter:

Genomic Locations for STEAP1 Gene

Genomic Locations for STEAP1 Gene
10,455 bases
Plus strand

Genomic View for STEAP1 Gene

Genes around STEAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP1 Gene

Proteins for STEAP1 Gene

  • Protein details for STEAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloreductase STEAP1
    Protein Accession:
    Secondary Accessions:
    • A4D1E0
    • O95034

    Protein attributes for STEAP1 Gene

    339 amino acids
    Molecular mass:
    39851 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for STEAP1 Gene

Post-translational modifications for STEAP1 Gene

No Post-translational modifications

Other Protein References for STEAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STEAP1 Gene

Domains & Families for STEAP1 Gene

Gene Families for STEAP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Transporters

Protein Domains for STEAP1 Gene


Suggested Antigen Peptide Sequences for STEAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STEAP family.
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP1: view

Function for STEAP1 Gene

Molecular function for STEAP1 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP1 Gene

Phenotypes From GWAS Catalog for STEAP1 Gene

Gene Ontology (GO) - Molecular Function for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10588738
GO:0008823 NOT cupric reductase activity IBA --
GO:0015267 channel activity TAS 10588738
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STEAP1: view
genes like me logo Genes that share phenotypes with STEAP1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STEAP1 Gene

Localization for STEAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP1 Gene

Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP1 gene
Compartment Confidence
plasma membrane 5
endosome 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005886 plasma membrane TAS 10588738
GO:0005887 integral component of plasma membrane TAS 10588738
GO:0005911 cell-cell junction TAS 10588738
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with STEAP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STEAP1 Gene

Pathways & Interactions for STEAP1 Gene

genes like me logo Genes that share pathways with STEAP1: view

Pathways by source for STEAP1 Gene

1 Cell Signaling Technology pathway for STEAP1 Gene
1 BioSystems pathway for STEAP1 Gene
1 KEGG pathway for STEAP1 Gene

Interacting Proteins for STEAP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9UHE8-STEA1_HUMAN ENSP00000297205 for STEAP1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015677 NOT copper ion import IBA --
GO:0055072 iron ion homeostasis IEA --
GO:0055085 transmembrane transport IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with STEAP1: view

No data available for SIGNOR curated interactions for STEAP1 Gene

Drugs & Compounds for STEAP1 Gene

(3) Drugs for STEAP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP1: view

Transcripts for STEAP1 Gene

mRNA/cDNA for STEAP1 Gene

Unigene Clusters for STEAP1 Gene

Six transmembrane epithelial antigen of the prostate 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP1 Gene

No ASD Table

Relevant External Links for STEAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STEAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STEAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP1 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for STEAP1 Gene

This gene is overexpressed in Prostate (53.3) and Fetal Liver (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STEAP1 Gene

Protein tissue co-expression partners for STEAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STEAP1 Gene:


SOURCE GeneReport for Unigene cluster for STEAP1 Gene:


mRNA Expression by UniProt/SwissProt for STEAP1 Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in prostate tumors.

Evidence on tissue expression from TISSUES for STEAP1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with STEAP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP1 Gene

Orthologs for STEAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STEAP1 34 33
  • 99.71 (n)
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
  • 90.66 (n)
(Bos Taurus)
Mammalia STEAP1 33
  • 90.86 (n)
-- 34
  • 89 (a)
(Mus musculus)
Mammalia Steap1 33 16 34
  • 82.89 (n)
(Rattus norvegicus)
Mammalia Steap1 33
  • 81.71 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
(Gallus gallus)
Aves STEAP1 33
  • 71.39 (n)
-- 34
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia steap1 33
  • 63.94 (n)
Species where no ortholog for STEAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STEAP1 Gene

Gene Tree for STEAP1 (if available)
Gene Tree for STEAP1 (if available)

Paralogs for STEAP1 Gene

Paralogs for STEAP1 Gene

(6) SIMAP similar genes for STEAP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP1: view

Variants for STEAP1 Gene

Sequence variations from dbSNP and Humsavar for STEAP1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000363727 -- 90,157,348(+) A/T intron_variant
rs1001449463 -- 90,157,876(+) G/A intron_variant
rs1002591534 -- 90,159,941(+) G/C intron_variant
rs1002795990 -- 90,152,608(+) G/T upstream_transcript_variant
rs1003361596 -- 90,165,115(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for STEAP1 Gene

Variant ID Type Subtype PubMed ID
dgv11493n54 CNV gain 21841781
dgv6525n100 CNV gain 25217958
dgv6529n100 CNV gain 25217958
esv2668491 CNV deletion 23128226
esv2752188 CNV gain 17911159
esv2759545 CNV gain 17122850
esv2762685 CNV loss 21179565
esv3576402 CNV gain 25503493
esv3614100 CNV loss 21293372
esv3614101 CNV gain 21293372
esv3614102 CNV loss 21293372
nsv464626 CNV gain 19166990
nsv508465 CNV deletion 20534489
nsv515997 CNV gain+loss 19592680
nsv981547 CNV duplication 23825009

Variation tolerance for STEAP1 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STEAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP1 Gene

Disorders for STEAP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STEAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
suppression of tumorigenicity 12
  • st12
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STEAP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STEAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STEAP1 Gene

Publications for STEAP1 Gene

  1. STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. (PMID: 10588738) Hubert RS … Afar DE (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 22 58
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  3. Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells. (PMID: 19915386) Valenti MT … Dalle Carbonare L (Journal of endocrinological investigation 2010) 3 22 58
  4. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N … Pharoah PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 44 58
  5. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. (PMID: 19196137) Vaghjiani RJ … Murphy CL (Tissue engineering. Part A 2009) 3 22 58

Products for STEAP1 Gene

Sources for STEAP1 Gene

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