Aliases for STEAP1 Gene
External Ids for STEAP1 Gene
Previous HGNC Symbols for STEAP1 Gene
Previous GeneCards Identifiers for STEAP1 Gene
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
GeneCards Summary for STEAP1 Gene
STEAP1 (STEAP Family Member 1) is a Protein Coding gene. Diseases associated with STEAP1 include Suppression Of Tumorigenicity 12 and Ewing Sarcoma. Among its related pathways are Mineral absorption and Copper homeostasis. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and channel activity. An important paralog of this gene is STEAP1B.
UniProtKB/Swiss-Prot for STEAP1 Gene
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).