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STEAP1 Gene

protein-coding   GIFtS: 57
GCID: GC07P089779

Six Transmembrane Epithelial Antigen Of The Prostate 1

(Previous name: six transmembrane epithelial antigen of the prostate)
(Previous symbol: STEAP)
  Search for STEAP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Six Transmembrane Epithelial Antigen Of The Prostate 11 2     Six Transmembrane Epithelial Antigen Of The Prostate1
STEAP1 2 3 5     Metalloreductase STEAP12
Six-Transmembrane Epithelial Antigen Of Prostate 12 3     EC 1.16.1.-3
PRSS242 3     

External Ids:    HGNC: 113781   Entrez Gene: 268722   Ensembl: ENSG000001646477   OMIM: 6044155   UniProtKB: Q9UHE83   

Export aliases for STEAP1 gene to outside databases

Previous GC identifers: GC07P089430 GC07P089622 GC07P084394


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STEAP1 Gene:
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell
lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface
antigen significantly expressed at cell-cell junctions. (provided by RefSeq, Jul 2008)

GeneCards Summary for STEAP1 Gene:
STEAP1 (six transmembrane epithelial antigen of the prostate 1) is a protein-coding gene. GO annotations related to this gene include transporter activity and channel activity. An important paralog of this gene is STEAP2.

UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+)
as acceptor (By similarity)

Gene Wiki entry for STEAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the STEAP1 gene promoter:
         TBP   NRSF form 1   HTF   MyoD   NRSF form 2   NF-AT   C/EBPalpha   CREB   TFIID   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTEAP1 promoter sequence
   Search Chromatin IP Primers for STEAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STEAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21

STEAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P089779:  view genomic region     (about GC identifiers)

Start:
89,783,689 bp from pter      End:
89,794,143 bp from pter
Size:
10,455 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 89,114,457-89,124,907     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8 (See protein sequence)
Recommended Name: Metalloreductase STEAP1  
Size: 339 amino acids; 39851 Da
Cofactor: FAD (By similarity)
Secondary accessions: A4D1E0 O95034

Explore the universe of human proteins at neXtProt for STEAP1: NX_Q9UHE8

Explore proteomics data for STEAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STEAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036581.1  
    ENSEMBL proteins: 
     ENSP00000297205   ENSP00000394402  

    STEAP1 Human Recombinant Protein Products:

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    Novus Biologicals STEAP1 Proteins
    Novus Biologicals STEAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STEAP1

     
    Search eBioscience for Proteins for STEAP1 

    STEAP1 Antibody Products:

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    STEAP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for STEAP1
    Cloud-Clone Corp. CLIAs for STEAP1
    Search eBioscience for ELISAs for STEAP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    1 InterPro protein domain:
     IPR013130 Fe3_Rdtase_TM_dom

    Graphical View of Domain Structure for InterPro Entry Q9UHE8

    ProtoNet protein and cluster: Q9UHE8

    UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8
    Similarity: Belongs to the STEAP family
    Similarity: Contains 1 ferric oxidoreductase domain


    Find genes that share domains with STEAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STEA1_HUMAN, Q9UHE8
    Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+)
    as acceptor (By similarity)

         Enzyme Number (IUBMB): EC 1.16.1.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10588738
    GO:0015267channel activity TAS10588738
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with STEAP1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STEAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STEAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STEAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STEAP1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat STEAP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate STEAP1:
    hsa-miR-203 hsa-miR-16-2* hsa-miR-195*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STEAP1
    Predesigned siRNA for gene silencing in human, mouse, rat STEAP1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for STEAP1

    Clone
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    OriGene ORF clones in mouse, rat for STEAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STEAP1 (NM_012449)
    Sino Biological Human cDNA Clone for STEAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STEAP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STEA1_HUMAN, Q9UHE8: Endosome membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane4
    peroxisome2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS10588738
    GO:0005887integral component of plasma membrane TAS10588738
    GO:0005911cell-cell junction TAS10588738
    GO:0010008endosome membrane IEA--

    Find genes that share ontologies with STEAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STEAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with STEAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for STEAP1):
        Mineral absorption

        Pathway & Disease-focused RT2 Profiler PCR Array including STEAP1: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for STEAP1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for STEAP1 (ENSP000002972054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0055072iron ion homeostasis IEA--
    GO:0055085transmembrane transport TAS10588738

    Find genes that share ontologies with STEAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STEAP1 (STEA1)

    3 HMDB Compounds for STEAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STEAP1 gene: 
    NM_012449.2  

    Unigene Cluster for STEAP1:

    Six transmembrane epithelial antigen of the prostate 1
    Hs.61635  [show with all ESTs]
    Unigene Representative Sequence: BF673939
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297205(uc003ujx.3) ENST00000475789(uc010lem.3) ENST00000412573

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STEAP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate STEAP1:
    hsa-miR-203 hsa-miR-16-2* hsa-miR-195*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STEAP1
    Predesigned siRNA for gene silencing in human, mouse, rat STEAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for STEAP1 (see all 7)
    OriGene ORF clones in mouse, rat for STEAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STEAP1 (NM_012449)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STEAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for STEAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STEAP1
      QuantiTect SYBR Green Assays in human, mouse, rat STEAP1
      QuantiFast Probe-based Assays in human, mouse, rat STEAP1

    Additional mRNA sequence: 

    AF186249.1 AK304076.1 AK308452.1 BC011802.2 

    7 DOTS entries:

    DT.442086  DT.75102235  DT.121114898  DT.100722967  DT.97781382  DT.100728980  DT.310260 

    Selected AceView cDNA sequences (see all 55):

    BQ082502 CA446381 BC011802 NM_012449 BQ014747 BX476756 BQ722891 BM738424 
    AA888312 BF003144 CB049384 AF186249 BG565247 BX103101 CB119996 BM738526 
    BM968995 BM995067 BE439545 BE881257 AI686139 BI552907 AI184070 BE875216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STEAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGGAAGA
    STEAP1 Expression
    About this image


    STEAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 1
             PureStem MEL2, NCr-fac Progenitor
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
             Human umbilical vein endothelial cells (HUVEC)
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    STEAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STEAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.61635

    UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8
    Tissue specificity: Ubiquitously expressed. Highly expressed in prostate tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including STEAP1: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STEAP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Steap11 , 5 six transmembrane epithelial antigen of the prostate more1, 5 82.89(n)1
    82.01(a)1
      5 (3.20 cM)5
    703581  NM_027399.31  NP_081675.21 
     57363175 
    chicken
    (Gallus gallus)
    Aves STEAP11 six transmembrane epithelial antigen of the prostate more 71.39(n)
    65.49(a)
      420540  XM_418642.3  XP_418642.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    6(20282895-20303132)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia steap11 six transmembrane epithelial antigen of the prostate more 63.94(n)
    57.55(a)
      100494347  XM_002939007.2  XP_002939053.1 


    ENSEMBL Gene Tree for STEAP1 (if available)
    TreeFam Gene Tree for STEAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STEAP1 gene
    STEAP22  STEAP1B2  STEAP42  STEAP32  
    6 SIMAP similar genes for STEAP1 using alignment to 2 protein entries:     STEA1_HUMAN (see all proteins):
    LOC392745    MGC87042    STEAP1B    STEAP2    STEAP3    STEAP4

    Find genes that share paralogs with STEAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STEAP1 (see all 295)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851035801,2
    --89781774(+) TAATTA/CGAAAA 1 -- us2k10--------
    rs281641,2
    C,F,A--89781826(+) CATATC/GAATAT 1 -- us2k14Minor allele frequency- G:0.01NA MN WA 270
    rs38577921,2
    C,F,H--89781950(+) TTTGTC/GTGACC 1 -- us2k1 tfbs312Minor allele frequency- G:0.35NS EA NA 528
    rs1878605841,2
    --89782089(+) GTTTCA/TCTAGA 1 -- us2k10--------
    rs1915722121,2
    C--89782125(+) CACCAC/TAAGGT 1 -- us2k10--------
    rs102763141,2
    --89782151(+) TTTAAC/GCTTCA 1 -- us2k1 tfbs30--------
    rs21902291,2
    C--89782461(+) TAATTA/C/Taaaaa 1 -- us2k1 tfbs3 trp31NA 2
    rs1999076501,2
    C--89782473(+) AAAAAA/GTAAAA 1 -- us2k10--------
    rs1837145571,2
    --89782517(+) TCTTCA/GGTGCC 1 -- us2k10--------
    rs1896773521,2
    --89782528(+) CTAGCA/TGTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STEAP1 (89783689 - 89794143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for STEAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668491CNV Deletion23128226
    nsv508465CNV Loss20534489
    esv2752188CNV Gain17911159
    nsv464626CNV Gain19166990
    nsv888709CNV Gain21882294
    nsv515997CNV Gain+Loss19592680
    dgv2117e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STEAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for STEAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604415    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for STEAP1:
    Prostate cancer

    Find genes that share disorders with STEAP1           About GenesLikeMe

    Genetic Association Database (GAD): STEAP1
    Human Genome Epidemiology (HuGE) Navigator: STEAP1 (2 documents)

    Export disorders for STEAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STEAP1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with STEAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. (PubMed id 10588738)1, 2, 9 Hubert R.S.... Afar D.E.H. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells. (PubMed id 19915386)1, 9 Valenti M.T....Dalle Carbonare L. (J. Endocrinol. Invest. 2010)
    8. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. (PubMed id 19196137)1, 9 Vaghjiani R.J....Murphy C.L. (Tissue Eng Part A 2009)
    9. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    10. Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells. (PubMed id 23060075)1 Gomes I.M....Maia C.J. (Prostate 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26872 HGNC: 11378 AceView: STEAP Ensembl:ENSG00000164647 euGenes: HUgn26872
    ECgene: STEAP1 Kegg: 26872 H-InvDB: STEAP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STEAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STEAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STEAP1 gene:
    Search GeneIP for patents involving STEAP1

    GeneCards and IP:
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