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Aliases for STEAP1 Gene

Aliases for STEAP1 Gene

  • Six Transmembrane Epithelial Antigen Of The Prostate 1 2 3 5
  • Six-Transmembrane Epithelial Antigen Of Prostate 1 3 4
  • PRSS24 3 4
  • STEAP 3 4
  • Six Transmembrane Epithelial Antigen Of The Prostate 2
  • EC 1.16.1.- 4

External Ids for STEAP1 Gene

Previous HGNC Symbols for STEAP1 Gene

  • STEAP

Previous GeneCards Identifiers for STEAP1 Gene

  • GC07P089430
  • GC07P089622
  • GC07P089779
  • GC07P084394

Summaries for STEAP1 Gene

Entrez Gene Summary for STEAP1 Gene

  • This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP1 Gene

STEAP1 (Six Transmembrane Epithelial Antigen Of The Prostate 1) is a Protein Coding gene. Among its related pathways are Mineral absorption. GO annotations related to this gene include oxidoreductase activity and channel activity. An important paralog of this gene is STEAP2.

UniProtKB/Swiss-Prot for STEAP1 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP1 Gene

Genomics for STEAP1 Gene

Regulatory Elements for STEAP1 Gene

Enhancers for STEAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STEAP1 on UCSC Golden Path with GeneCards custom track

Promoters for STEAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STEAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for STEAP1 Gene

Chromosome:
7
Start:
90,154,375 bp from pter
End:
90,164,829 bp from pter
Size:
10,455 bases
Orientation:
Plus strand

Genomic View for STEAP1 Gene

Genes around STEAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP1 Gene

Proteins for STEAP1 Gene

  • Protein details for STEAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHE8-STEA1_HUMAN
    Recommended name:
    Metalloreductase STEAP1
    Protein Accession:
    Q9UHE8
    Secondary Accessions:
    • A4D1E0
    • O95034

    Protein attributes for STEAP1 Gene

    Size:
    339 amino acids
    Molecular mass:
    39851 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for STEAP1 Gene

Proteomics data for STEAP1 Gene at MOPED

Post-translational modifications for STEAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STEAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STEAP1 Gene

Domains & Families for STEAP1 Gene

Gene Families for STEAP1 Gene

Protein Domains for STEAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STEAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHE8

UniProtKB/Swiss-Prot:

STEA1_HUMAN :
  • Contains 1 ferric oxidoreductase domain.
  • Belongs to the STEAP family.
Domain:
  • Contains 1 ferric oxidoreductase domain.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP1: view

Function for STEAP1 Gene

Molecular function for STEAP1 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP1 Gene

Gene Ontology (GO) - Molecular Function for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015267 channel activity TAS 10588738
genes like me logo Genes that share ontologies with STEAP1: view
genes like me logo Genes that share phenotypes with STEAP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STEAP1

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STEAP1 Gene

Localization for STEAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP1 Gene

Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STEAP1 Gene COMPARTMENTS Subcellular localization image for STEAP1 gene
Compartment Confidence
plasma membrane 5
endosome 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with STEAP1: view

Pathways & Interactions for STEAP1 Gene

SuperPathways for STEAP1 Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with STEAP1: view

Pathways by source for STEAP1 Gene

1 KEGG pathway for STEAP1 Gene

Interacting Proteins for STEAP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297205%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000297205 for STEAP1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015677 NOT copper ion import IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with STEAP1: view

No data available for SIGNOR curated interactions for STEAP1 Gene

Drugs & Compounds for STEAP1 Gene

(3) Drugs for STEAP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP1: view

Transcripts for STEAP1 Gene

mRNA/cDNA for STEAP1 Gene

Unigene Clusters for STEAP1 Gene

Six transmembrane epithelial antigen of the prostate 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP1 Gene

No ASD Table

Relevant External Links for STEAP1 Gene

GeneLoc Exon Structure for
STEAP1
ECgene alternative splicing isoforms for
STEAP1

Expression for STEAP1 Gene

mRNA expression in normal human tissues for STEAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP1 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for STEAP1 Gene

This gene is overexpressed in Prostate (53.3) and Fetal Liver (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STEAP1 Gene



SOURCE GeneReport for Unigene cluster for STEAP1 Gene Hs.61635

mRNA Expression by UniProt/SwissProt for STEAP1 Gene

Q9UHE8-STEA1_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in prostate tumors.
genes like me logo Genes that share expression patterns with STEAP1: view

Protein tissue co-expression partners for STEAP1 Gene

- Elite partner

Primer Products

Orthologs for STEAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STEAP1 35
  • 90.86 (n)
  • 89.38 (a)
-- 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STEAP1 35
  • 90.66 (n)
  • 90.56 (a)
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Steap1 35
  • 82.89 (n)
  • 82.01 (a)
Steap1 16
Steap1 36
  • 82 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia STEAP1 35
  • 99.71 (n)
  • 99.41 (a)
STEAP1 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Steap1 35
  • 81.71 (n)
  • 82.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves STEAP1 35
  • 71.39 (n)
  • 65.49 (a)
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia steap1 35
  • 63.94 (n)
  • 57.55 (a)
Species with no ortholog for STEAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STEAP1 Gene

ENSEMBL:
Gene Tree for STEAP1 (if available)
TreeFam:
Gene Tree for STEAP1 (if available)

Paralogs for STEAP1 Gene

Paralogs for STEAP1 Gene

(6) SIMAP similar genes for STEAP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP1: view

Variants for STEAP1 Gene

Sequence variations from dbSNP and Humsavar for STEAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_053696 -
VAR_053697 -

Structural Variations from Database of Genomic Variants (DGV) for STEAP1 Gene

Variant ID Type Subtype PubMed ID
esv2752188 CNV Gain 17911159
nsv464626 CNV Gain 19166990
nsv888709 CNV Gain 21882294
esv2668491 CNV Deletion 23128226
nsv515997 CNV Gain+Loss 19592680
dgv2117e1 CNV Complex 17122850
nsv508465 CNV Loss 20534489

Variation tolerance for STEAP1 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STEAP1 Gene

Disorders for STEAP1 Gene

Relevant External Links for STEAP1

Genetic Association Database (GAD)
STEAP1
Human Genome Epidemiology (HuGE) Navigator
STEAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STEAP1

No disorders were found for STEAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STEAP1 Gene

Publications for STEAP1 Gene

  1. STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. (PMID: 10588738) Hubert R.S. … Afar D.E.H. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23 67
  2. Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells. (PMID: 19915386) Valenti M.T. … Dalle Carbonare L. (J. Endocrinol. Invest. 2010) 3 23
  3. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. (PMID: 19196137) Vaghjiani R.J. … Murphy C.L. (Tissue Eng Part A 2009) 3 23
  4. STEAP1 is overexpressed in prostate cancer and prostatic intraepithelial neoplasia lesions, and it is positively associated with Gleason score. (PMID: 24239460) Gomes I.M. … Maia C.J. (Urol. Oncol. 2014) 3
  5. Annotating STEAP1 regulation in prostate cancer with 89Zr immuno-PET. (PMID: 25453051) Doran M.G. … Lewis J.S. (J. Nucl. Med. 2014) 3

Products for STEAP1 Gene

Sources for STEAP1 Gene

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