Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STEAP1 Gene

protein-coding   GIFtS: 58
GCID: GC07P089779

Six Transmembrane Epithelial Antigen Of The Prostate 1

(Previous name: six transmembrane epithelial antigen of the prostate)
(Previous symbol: STEAP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Six Transmembrane Epithelial Antigen Of The Prostate 11 2     Six Transmembrane Epithelial Antigen Of The Prostate1
STEAP1 2 3 5     Metalloreductase STEAP12
Six-Transmembrane Epithelial Antigen Of Prostate 12 3     EC 1.16.1.-3
PRSS242 3     

External Ids:    HGNC: 113781   Entrez Gene: 268722   Ensembl: ENSG000001646477   OMIM: 6044155   UniProtKB: Q9UHE83   

Export aliases for STEAP1 gene to outside databases

Previous GC identifers: GC07P089430 GC07P089622 GC07P084394


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STEAP1 Gene:
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell
lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface
antigen significantly expressed at cell-cell junctions. (provided by RefSeq, Jul 2008)

GeneCards Summary for STEAP1 Gene: 
STEAP1 (six transmembrane epithelial antigen of the prostate 1) is a protein-coding gene. Diseases associated with STEAP1 include prostatitis, and ewing's family of tumors. GO annotations related to this gene include transporter activity and channel activity. An important paralog of this gene is STEAP2.

UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+)
as acceptor (By similarity)

Gene Wiki entry for STEAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STEAP1 gene promoter:
         TBP   NRSF form 1   HTF   MyoD   NRSF form 2   NF-AT   C/EBPalpha   CREB   TFIID   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTEAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STEAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21

STEAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STEAP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P089779:  view genomic region     (about GC identifiers)

Start:
89,783,689 bp from pter      End:
89,794,143 bp from pter
Size:
10,455 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 89,114,457-89,124,907     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8 (See protein sequence)
Recommended Name: Metalloreductase STEAP1  
Size: 339 amino acids; 39851 Da
Cofactor: FAD (By similarity)
Subcellular location: Endosome membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A4D1E0 O95034

Explore the universe of human proteins at neXtProt for STEAP1: NX_Q9UHE8

Explore proteomics data for STEAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHE8

  • STEAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STEAP1 Protein Expression
    REFSEQ proteins: NP_036581.1  
    ENSEMBL proteins: 
     ENSP00000297205   ENSP00000394402  

    Human Recombinant Protein Products for STEAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STEAP1
    OriGene Protein Over-expression Lysate for STEAP1
    OriGene MassSpec for STEAP1 
    OriGene Custom Protein Services for STEAP1
    GenScript Custom Purified and Recombinant Proteins Services for STEAP1
    Novus Biologicals STEAP1 Proteins
    Novus Biologicals STEAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STEAP1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS10588738
    GO:0005887integral to plasma membrane TAS10588738
    GO:0005911cell-cell junction TAS10588738
    GO:0010008endosome membrane IEA--

    STEAP1 for ontologies           About GeneDecksing



    STEAP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for STEAP1
    OriGene Antibodies for STEAP1
    OriGene Custom Antibody Services for STEAP1
    GenScript Custom Superior Antibodies Services for STEAP1
    Novus Biologicals STEAP1 Antibodies
    Abcam antibodies for STEAP1
    Cloud-Clone Corp. Antibodies for STEAP1 
    ThermoFisher Antibodies for STEAP1
    LSBio Antibodies in human, mouse, rat for STEAP1 

    Assay Products for STEAP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STEAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STEAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STEAP1 
    Cloud-Clone Corp. CLIAs for STEAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRSS: Serine peptidases / Serine peptidases

    1 InterPro protein domain:
     IPR013130 Fe3_Rdtase_TM_dom

    Graphical View of Domain Structure for InterPro Entry Q9UHE8

    ProtoNet protein and cluster: Q9UHE8

    UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8
    Similarity: Belongs to the STEAP family
    Similarity: Contains 1 ferric oxidoreductase domain


    STEAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STEA1_HUMAN, Q9UHE8
    Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+)
    as acceptor (By similarity)

         Enzyme Number (IUBMB): EC 1.16.1.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10588738
    GO:0015267channel activity TAS10588738
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding IEA--
         
    STEAP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STEAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STEAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STEAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STEAP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP1:
    hsa-miR-203 hsa-miR-16-2* hsa-miR-195*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STEAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STEAP1
    Sirion Biotech Customized adenovirus for overexpression of STEAP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STEAP1 (see all 8)
    OriGene ORF clones in mouse, rat for STEAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STEAP1 (NM_012449)
    Sino Biological Human cDNA Clone for STEAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1
    Sirion Biotech Customized lentivirus for stable overexpression of STEAP1 
                         Customized lentivirus expression plasmids for stable overexpression of STEAP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STEAP1
    Search LifeMap BioReagents cell lines for STEAP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STEAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for STEAP1):
        Mineral absorption


    STEAP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STEAP1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for STEAP1 (ENSP000002972054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0022900electron transport chain ----
    GO:0055072iron ion homeostasis IEA--

    STEAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STEAP1 (STEA1)

    3 HMDB Compounds for STEAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    Search CenterWatch for drugs/clinical trials and news about STEAP1 / STEA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STEAP1 gene: 
    NM_012449.2  

    Unigene Cluster for STEAP1:

    Six transmembrane epithelial antigen of the prostate 1
    Hs.61635  [show with all ESTs]
    Unigene Representative Sequence: BF673939
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297205(uc003ujx.3) ENST00000475789(uc010lem.3) ENST00000412573

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STEAP1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate STEAP1:
    hsa-miR-203 hsa-miR-16-2* hsa-miR-195*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STEAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for STEAP1 (see all 8)
    OriGene ORF clones in mouse, rat for STEAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STEAP1 (NM_012449)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STEAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1
    Sirion Biotech Customized lentivirus for stable overexpression of STEAP1 
                         Customized lentivirus expression plasmids for stable overexpression of STEAP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STEAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for STEAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STEAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP1

    Additional mRNA sequence: 

    AF186249.1 AK304076.1 AK308452.1 BC011802.2 

    7 DOTS entries:

    DT.442086  DT.75102235  DT.121114898  DT.100722967  DT.97781382  DT.100728980  DT.310260 

    24/55 AceView cDNA sequences (see all 55):

    BQ014747 BC011802 AF186249 BM738424 CA446381 BF003144 BQ722891 BQ082502 
    NM_012449 CB049384 BX476756 AA888312 AA316181 AI184070 BM995067 BI552907 
    BU930271 BE439545 CA488012 AI394674 AI686139 BM968995 BM675259 BX103101 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STEAP1 expression in normal human tissues (normalized intensities)      STEAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGGAAGA
    STEAP1 Expression
    About this image


    STEAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 1
             PureStem MEL2, NCr-fac Progenitor
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Guard Dermal Papilla Cells Dermal Papilla
             Human Hair Outer Root Sheath Cells (HHORSC)   
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Prostate Fibroblasts (HPrF)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor F15
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood endothelial colony-forming cells

    See STEAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STEAP1

    SOURCE GeneReport for Unigene cluster: Hs.61635

    UniProtKB/Swiss-Prot: STEA1_HUMAN, Q9UHE8
    Tissue specificity: Ubiquitously expressed. Highly expressed in prostate tumors

        SABiosciences Expression via Pathway-Focused PCR Array including STEAP1: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STEAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for STEAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STEAP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for STEAP1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Steap11 , 5 six transmembrane epithelial antigen of the prostate more1, 5 82.89(n)1
    82.01(a)1
      5 (3.20 cM)5
    703581  NM_027399.31  NP_081675.21 
     57363175 
    chicken
    (Gallus gallus)
    Aves STEAP11 six transmembrane epithelial antigen of the prostate more 71.8(n)
    66.16(a)
      420540  XM_418642.2  XP_418642.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    6(20282895-20303132)


    ENSEMBL Gene Tree for STEAP1 (if available)
    TreeFam Gene Tree for STEAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STEAP1 gene
    STEAP22  STEAP1B2  STEAP42  STEAP32  
    6 SIMAP similar genes for STEAP1 using alignment to 2 protein entries:     STEA1_HUMAN (see all proteins):
    LOC392745    MGC87042    STEAP1B    STEAP2    STEAP3    STEAP4

    STEAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/295 SNPs in STEAP1 are shown (see all 295)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851035801,2
    --89781774(+) TAATTA/CGAAAA 1 -- us2k10--------
    rs281641,2
    C,F,A--89781826(+) CATATC/GAATAT 1 -- us2k14Minor allele frequency- G:0.01NA MN WA 270
    rs38577921,2
    C,F,H--89781950(+) TTTGTC/GTGACC 1 -- us2k1 tfbs312Minor allele frequency- G:0.35NS EA NA 528
    rs1878605841,2
    --89782089(+) GTTTCA/TCTAGA 1 -- us2k10--------
    rs1915722121,2
    C--89782125(+) CACCAC/TAAGGT 1 -- us2k10--------
    rs102763141,2
    --89782151(+) TTTAAC/GCTTCA 1 -- us2k1 tfbs30--------
    rs21902291,2
    C--89782461(+) TAATTA/C/Taaaaa 1 -- us2k1 tfbs3 trp31NA 2
    rs1999076501,2
    C--89782473(+) AAAAAA/GTAAAA 1 -- us2k10--------
    rs1837145571,2
    --89782517(+) TCTTCA/GGTGCC 1 -- us2k10--------
    rs1896773521,2
    --89782528(+) CTAGCA/TGTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for STEAP1 (89783689 - 89794143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for STEAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668491CNV Deletion23128226
    nsv508465CNV Loss20534489
    esv2752188CNV Gain17911159
    nsv464626CNV Gain19166990
    nsv888709CNV Gain21882294
    nsv515997CNV Gain+Loss19592680
    dgv2117e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STEAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for STEAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604415    OMIM disorders: --

    7 diseases for STEAP1:    About MalaCards
    prostatitis    ewing's family of tumors    ovarian cancer    prostate cancer
    sarcoma    adenocarcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for STEAP1:
    Prostate cancer

    STEAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STEAP1
    Human Genome Epidemiology (HuGE) Navigator: STEAP1 (2 documents)

    Export disorders for STEAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STEAP1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with STEAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. (PubMed id 10588738)1, 2, 9 Hubert R.S.... Afar D.E.H. (1999)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Zoledronic acid decreases mRNA six-transmembrane epit helial antigen of prostate protein expression in prostate cancer cells. (PubMed id 19915386)1, 9 Valenti M.T....Dalle Carbonare L. (2010)
    8. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal st em cells. (PubMed id 19196137)1, 9 Vaghjiani R.J....Murphy C.L. (2009)
    9. Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells. (PubMed id 23060075)1 Gomes I.M....Maia C.J. (2013)
    10. STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors. (PubMed id 22080479)1 Grunewald T.G....Burdach S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26872 HGNC: 11378 AceView: STEAP Ensembl:ENSG00000164647 euGenes: HUgn26872
    ECgene: STEAP1 Kegg: 26872 H-InvDB: STEAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STEAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STEAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STEAP1 gene:
    Search GeneIP for patents involving STEAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for STEAP1 (STEAP1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for STEAP1 (STEAP1)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STEAP1   OriGene RNAi products in human, mouse, rat for STEAP1  
     OriGene qPCR primer pairs and template standards for STEAP1   OriGene Protein Over-expression Lysate for STEAP1  
     OriGene MassSpec something-or-other for STEAP1   OriGene clones in human, mouse for STEAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for STEAP1   OriGene Purified Protein for STEAP1  
     OriGene ORF clones in mouse, rat for STEAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STEAP1   OriGene Custom Protein Services for STEAP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STEAP1
     QIAGEN SeqTarget long-range PCR primers for resequencing STEAP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STEAP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STEAP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STEAP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STEAP1
     GenScript Custom Purified and Recombinant Proteins Services for STEAP1 GenScript cDNA clones with any tag delivered in your preferred vector for STEAP1
     GenScript Custom Assay Services for STEAP1 GenScript Custom Superior Antibodies Services for STEAP1
     GenScript Custom overexpressing Cell Line Services for STEAP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in STEAP1 promoter
     Search Chromatin IP Primers for STEAP1
     RT2 qPCR Primer Assay in human, mouse, rat STEAP1
     Search GNC Networks for STEAP1
     SABiosciences PCR Arrays including human, mouse, rat STEAP1
     Search Tocris compounds for STEAP1 (STEA1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for STEAP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STEAP1 antibodies
     STEAP1 proteins
     STEAP1 lysates
     Antibodies for STEAP1
     See all of Abcam's Antibodies, Kits and Proteins for STEAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STEAP1
     Antibodies for STEAP1
     ELISAs for STEAP1
     CLIAs for STEAP1
     Search LifeMap BioReagents cell lines for STEAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STEAP1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for STEAP1
     SwitchGear Promoter luciferase reporter plasmids for STEAP1
     ThermoFisher Antibodies for STEAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STEAP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STEAP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STEAP1
    Customized:
     lentivirus for stable overexpression of STEAP1
     lentivirus expression plasmids for stable overexpression of STEAP1
     adenovirus for overexpression of STEAP1
     LSBio Antibodies in human, mouse, rat for STEAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STEAP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4