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Aliases for STEAP1 Gene

Aliases for STEAP1 Gene

  • STEAP Family Member 1 2 3 5
  • Six Transmembrane Epithelial Antigen Of The Prostate 1 2 3
  • Six-Transmembrane Epithelial Antigen Of Prostate 1 3 4
  • STEAP1 Metalloreductase 2 3
  • PRSS24 3 4
  • STEAP 3 4
  • Six Transmembrane Epithelial Antigen Of The Prostate 2
  • Metalloreductase STEAP1 3
  • EC 1.16.1.- 4

External Ids for STEAP1 Gene

Previous HGNC Symbols for STEAP1 Gene

  • STEAP

Previous GeneCards Identifiers for STEAP1 Gene

  • GC07P089430
  • GC07P089622
  • GC07P089779
  • GC07P084394

Summaries for STEAP1 Gene

Entrez Gene Summary for STEAP1 Gene

  • This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP1 Gene

STEAP1 (STEAP Family Member 1) is a Protein Coding gene. Among its related pathways are Copper homeostasis and Glucose / Energy Metabolism. GO annotations related to this gene include oxidoreductase activity and channel activity. An important paralog of this gene is STEAP1B.

UniProtKB/Swiss-Prot for STEAP1 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP1 Gene

Genomics for STEAP1 Gene

Regulatory Elements for STEAP1 Gene

Enhancers for STEAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G090177 1.4 Ensembl ENCODE dbSUPER 49.3 +25.1 25073 3.2 ELF3 FOXA2 NFIB SIN3A BMI1 GATA2 FOS RELB IKZF2 CREM STEAP1 GTPBP10 STEAP2 STEAP2-AS1
GH07G090173 1.2 FANTOM5 dbSUPER 48.5 +18.9 18899 0.3 ELF3 TBP FOXA2 ARID4B RAD21 ZBTB40 RARA YY1 RELB IKZF2 STEAP1 STEAP2 STEAP2-AS1
GH07G090210 1.3 ENCODE dbSUPER 39.6 +57.3 57273 2.3 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF263 SP3 SP5 STEAP1 STEAP2 STEAP2-AS1 GC07P090219
GH07G090345 1.1 ENCODE 26.8 +192.3 192349 2.7 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 STEAP1 GTPBP10 STEAP2 ENSG00000280440 CLDN12
GH07G090187 0.5 ENCODE 50.6 +34.3 34339 1.8 ELF3 MTA2 IKZF1 IKZF2 EP300 STEAP1 STEAP2 CFAP69 ENSG00000207488 STEAP2-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STEAP1 on UCSC Golden Path with GeneCards custom track

Promoters for STEAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214876 125 1001 HDGF ATF1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1

Genomic Location for STEAP1 Gene

Chromosome:
7
Start:
90,154,375 bp from pter
End:
90,164,829 bp from pter
Size:
10,455 bases
Orientation:
Plus strand

Genomic View for STEAP1 Gene

Genes around STEAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP1 Gene

Proteins for STEAP1 Gene

  • Protein details for STEAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHE8-STEA1_HUMAN
    Recommended name:
    Metalloreductase STEAP1
    Protein Accession:
    Q9UHE8
    Secondary Accessions:
    • A4D1E0
    • O95034

    Protein attributes for STEAP1 Gene

    Size:
    339 amino acids
    Molecular mass:
    39851 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for STEAP1 Gene

Post-translational modifications for STEAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STEAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STEAP1 (STEAP1)

No data available for DME Specific Peptides for STEAP1 Gene

Domains & Families for STEAP1 Gene

Gene Families for STEAP1 Gene

Protein Domains for STEAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STEAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHE8

UniProtKB/Swiss-Prot:

STEA1_HUMAN :
  • Belongs to the STEAP family.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP1: view

Function for STEAP1 Gene

Molecular function for STEAP1 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP1 Gene

Gene Ontology (GO) - Molecular Function for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10588738
GO:0008823 NOT cupric reductase activity IBA --
GO:0015267 channel activity TAS 10588738
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STEAP1: view
genes like me logo Genes that share phenotypes with STEAP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STEAP1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STEAP1 Gene

Localization for STEAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP1 Gene

Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP1 gene
Compartment Confidence
plasma membrane 5
endosome 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA,IEA --
GO:0005886 plasma membrane TAS 10588738
GO:0005887 integral component of plasma membrane TAS 10588738
GO:0005911 cell-cell junction TAS 10588738
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with STEAP1: view

Pathways & Interactions for STEAP1 Gene

genes like me logo Genes that share pathways with STEAP1: view

Pathways by source for STEAP1 Gene

1 Cell Signaling Technology pathway for STEAP1 Gene
1 BioSystems pathway for STEAP1 Gene
1 KEGG pathway for STEAP1 Gene

Interacting Proteins for STEAP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297205%0d%0a9606.ENSP00000287908%0d%0a9606.ENSP00000310129%0d%0a
Selected Interacting proteins: Q9UHE8-STEA1_HUMAN ENSP00000297205 for STEAP1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for STEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015677 NOT copper ion import IBA --
GO:0055072 iron ion homeostasis IEA --
GO:0055085 transmembrane transport IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with STEAP1: view

No data available for SIGNOR curated interactions for STEAP1 Gene

Drugs & Compounds for STEAP1 Gene

(3) Drugs for STEAP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP1: view

Transcripts for STEAP1 Gene

mRNA/cDNA for STEAP1 Gene

Unigene Clusters for STEAP1 Gene

Six transmembrane epithelial antigen of the prostate 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP1 Gene

No ASD Table

Relevant External Links for STEAP1 Gene

GeneLoc Exon Structure for
STEAP1
ECgene alternative splicing isoforms for
STEAP1

Expression for STEAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STEAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP1 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for STEAP1 Gene

This gene is overexpressed in Prostate (53.3) and Fetal Liver (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STEAP1 Gene



Protein tissue co-expression partners for STEAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STEAP1 Gene:

STEAP1

SOURCE GeneReport for Unigene cluster for STEAP1 Gene:

Hs.61635

mRNA Expression by UniProt/SwissProt for STEAP1 Gene:

Q9UHE8-STEA1_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in prostate tumors.

Evidence on tissue expression from TISSUES for STEAP1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with STEAP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP1 Gene

Orthologs for STEAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STEAP1 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
STEAP1 34
  • 90.66 (n)
cow
(Bos Taurus)
Mammalia STEAP1 34
  • 90.86 (n)
-- 35
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Steap1 34 16 35
  • 82.89 (n)
rat
(Rattus norvegicus)
Mammalia Steap1 34
  • 81.71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves STEAP1 34
  • 71.39 (n)
-- 35
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia steap1 34
  • 63.94 (n)
Species where no ortholog for STEAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STEAP1 Gene

ENSEMBL:
Gene Tree for STEAP1 (if available)
TreeFam:
Gene Tree for STEAP1 (if available)

Paralogs for STEAP1 Gene

Paralogs for STEAP1 Gene

(6) SIMAP similar genes for STEAP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STEAP1: view

Variants for STEAP1 Gene

Sequence variations from dbSNP and Humsavar for STEAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000363727 -- 90,157,348(+) CTTAG(A/T)GCATG intron-variant
rs1001449463 -- 90,157,876(+) AAGGC(A/G)GGATT intron-variant
rs1002591534 -- 90,159,941(+) ATTCT(C/G)TATCT intron-variant
rs1002795990 -- 90,152,608(+) CAAAT(G/T)TTAAA intron-variant, upstream-variant-2KB
rs1003361596 -- 90,165,115(+) CTTAC(A/G)ATTGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for STEAP1 Gene

Variant ID Type Subtype PubMed ID
dgv11493n54 CNV gain 21841781
dgv6525n100 CNV gain 25217958
dgv6529n100 CNV gain 25217958
esv2668491 CNV deletion 23128226
esv2752188 CNV gain 17911159
esv2759545 CNV gain 17122850
esv2762685 CNV loss 21179565
esv3576402 CNV gain 25503493
esv3614100 CNV loss 21293372
esv3614101 CNV gain 21293372
esv3614102 CNV loss 21293372
nsv464626 CNV gain 19166990
nsv508465 CNV deletion 20534489
nsv515997 CNV gain+loss 19592680
nsv981547 CNV duplication 23825009

Variation tolerance for STEAP1 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STEAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STEAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP1 Gene

Disorders for STEAP1 Gene

Relevant External Links for STEAP1

Genetic Association Database (GAD)
STEAP1
Human Genome Epidemiology (HuGE) Navigator
STEAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STEAP1

No disorders were found for STEAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STEAP1 Gene

Publications for STEAP1 Gene

  1. STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. (PMID: 10588738) Hubert R.S. … Afar D.E.H. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 22 64
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  3. Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells. (PMID: 19915386) Valenti M.T. … Dalle Carbonare L. (J. Endocrinol. Invest. 2010) 3 22 64
  4. Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. (PMID: 19196137) Vaghjiani R.J. … Murphy C.L. (Tissue Eng Part A 2009) 3 22 64
  5. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N. … Pharoah P.D. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 46 64

Products for STEAP1 Gene

Sources for STEAP1 Gene

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