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Aliases for STC2 Gene

Aliases for STC2 Gene

  • Stanniocalcin 2 2 3
  • Stanniocalcin-Related Protein 3 4
  • STC-Related Protein 3 4
  • STC-2 3 4
  • STCRP 3 4
  • Stanniocalcin-2 3

External Ids for STC2 Gene

Previous GeneCards Identifiers for STC2 Gene

  • GC05M173001
  • GC05M173443
  • GC05M172677
  • GC05M172722
  • GC05M172674
  • GC05M172741
  • GC05M167836

Summaries for STC2 Gene

Entrez Gene Summary for STC2 Gene

  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for STC2 Gene

STC2 (Stanniocalcin 2) is a Protein Coding gene. GO annotations related to this gene include hormone activity. An important paralog of this gene is STC1.

UniProtKB/Swiss-Prot for STC2 Gene

  • Has an anti-hypocalcemic action on calcium and phosphate homeostasis

Gene Wiki entry for STC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STC2 Gene

Genomics for STC2 Gene

Regulatory Elements for STC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STC2 Gene

Start:
173,314,713 bp from pter
End:
173,329,503 bp from pter
Size:
14,791 bases
Orientation:
Minus strand

Genomic View for STC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STC2 Gene

Proteins for STC2 Gene

  • Protein details for STC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76061-STC2_HUMAN
    Recommended name:
    Stanniocalcin-2
    Protein Accession:
    O76061
    Secondary Accessions:

    Protein attributes for STC2 Gene

    Size:
    302 amino acids
    Molecular mass:
    33249 Da
    Quaternary structure:
    • Homodimer; disulfide-linked

neXtProt entry for STC2 Gene

Proteomics data for STC2 Gene at MOPED

Post-translational modifications for STC2 Gene

  • Glycosylation at Asn73 and Thr232
  • Modification sites at PhosphoSitePlus

Other Protein References for STC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STC2 Gene

Domains for STC2 Gene

Protein Domains for STC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STC2 Gene

Graphical View of Domain Structure for InterPro Entry

O76061

UniProtKB/Swiss-Prot:

STC2_HUMAN :
  • O76061
Family:
  • Belongs to the stanniocalcin family.
genes like me logo Genes that share domains with STC2: view

No data available for Gene Families for STC2 Gene

Function for STC2 Gene

Molecular function for STC2 Gene

UniProtKB/Swiss-Prot Function: Has an anti-hypocalcemic action on calcium and phosphate homeostasis

Gene Ontology (GO) - Molecular Function for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005515 protein binding --
GO:0019899 enzyme binding IDA 22503972
GO:0020037 heme binding IDA 22503972
GO:0042803 protein homodimerization activity IDA 15486227
genes like me logo Genes that share ontologies with STC2: view
genes like me logo Genes that share phenotypes with STC2: view

Animal Models for STC2 Gene

MGI Knock Outs for STC2:

Animal Model Products

CRISPR Products

miRNA for STC2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STC2 Gene

Localization for STC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STC2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STC2 Gene COMPARTMENTS Subcellular localization image for STC2 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
golgi apparatus 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 16502470
GO:0005783 endoplasmic reticulum IDA 22503972
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IDA 22503972
genes like me logo Genes that share ontologies with STC2: view

Pathways for STC2 Gene

SuperPathways for STC2 Gene

No Data Available

Interacting Proteins for STC2 Gene

Gene Ontology (GO) - Biological Process for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007566 embryo implantation IEA --
GO:0010629 negative regulation of gene expression IDA 9753616
GO:0030968 endoplasmic reticulum unfolded protein response IEA --
genes like me logo Genes that share ontologies with STC2: view

No data available for Pathways by source for STC2 Gene

Compounds for STC2 Gene

(1) HMDB Compounds for STC2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Novoseek inferred chemical compound relationships for STC2 Gene

Compound -log(P) Hits PubMed IDs
calcium 37.9 5
estrogen 31.6 6
estradiol 22.5 3
histidine 18.2 1
genes like me logo Genes that share compounds with STC2: view

Transcripts for STC2 Gene

Unigene Clusters for STC2 Gene

Stanniocalcin 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STC2 Gene

No ASD Table

Relevant External Links for STC2 Gene

GeneLoc Exon Structure for
STC2
ECgene alternative splicing isoforms for
STC2

Expression for STC2 Gene

mRNA expression in normal human tissues for STC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STC2 Gene

This gene is overexpressed in Breast - Mammary Tissue (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STC2 Gene

SOURCE GeneReport for Unigene cluster for STC2 Gene Hs.233160

mRNA Expression by UniProt/SwissProt for STC2 Gene

O76061-STC2_HUMAN
Tissue specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes
genes like me logo Genes that share expressions with STC2: view

In Situ Assay Products

Orthologs for STC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STC2 35
  • 99.45 (n)
  • 99.67 (a)
STC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STC2 35
  • 90.4 (n)
  • 91.06 (a)
STC2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STC2 35
  • 91.52 (n)
  • 92.73 (a)
STC2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stc2 35
  • 84.57 (n)
  • 87.5 (a)
Stc2 16
Stc2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STC2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STC2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stc2 35
  • 84.57 (n)
  • 85.81 (a)
chicken
(Gallus gallus)
Aves STC2 35
  • 71.25 (n)
  • 71.14 (a)
STC2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STC2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stc2 35
  • 65.09 (n)
  • 67.57 (a)
zebrafish
(Danio rerio)
Actinopterygii stc2a 35
  • 61.58 (n)
  • 59.93 (a)
stc2a 36
  • 58 (a)
OneToMany
stc2b 36
  • 46 (a)
OneToMany
Species with no ortholog for STC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STC2 Gene

ENSEMBL:
Gene Tree for STC2 (if available)
TreeFam:
Gene Tree for STC2 (if available)

Paralogs for STC2 Gene

Paralogs for STC2 Gene

Selected SIMAP similar genes for STC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STC2: view

Variants for STC2 Gene

Sequence variations from dbSNP and Humsavar for STC2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1135097 -- 173,316,557(-) AGAGA(C/G)AGAAC utr-variant-3-prime
rs1169277 -- 173,327,778(+) GCTTC(A/G)TTTCC intron-variant
rs1802502 -- 173,323,254(-) ATAGT(A/G/T)GAGAT synonymous-codon, reference
rs2053681 -- 173,319,083(+) AGCTC(A/G)CTGTG intron-variant
rs2277949 -- 173,323,117(+) TTTGA(A/C)AGGCA intron-variant

Relevant External Links for STC2 Gene

HapMap Linkage Disequilibrium report
STC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for STC2 Gene

Disorders for STC2 Gene

(3) Novoseek inferred disease relationships for STC2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 29.6 15
carcinoma renal cell 16 2
tumors 8.98 12

Relevant External Links for STC2

Genetic Association Database (GAD)
STC2
Human Genome Epidemiology (HuGE) Navigator
STC2
genes like me logo Genes that share disorders with STC2: view

No data available for UniProtKB/Swiss-Prot for STC2 Gene

Publications for STC2 Gene

  1. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. (PMID: 9723890) Chang A.C.-M. … Reddel R.R. (Mol. Cell. Endocrinol. 1998) 2 3 4 23
  2. Molecular cloning of a second human stanniocalcin homologue (STC2). (PMID: 9753616) Ishiabshi K. … Imai M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. Molecular cloning and characterization of stanniocalcin-related protein. (PMID: 10022771) DiMattia G.E. … Wagner G.F. (Mol. Cell. Endocrinol. 1998) 3 4 23
  4. Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. (PMID: 10450831) Moore E.E. … de Jongh K.S. (Horm. Metab. Res. 1999) 3 4 23
  5. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. (PMID: 10947959) Jellinek D.A. … Reddel R.R. (Biochem. J. 2000) 3 23

Products for STC2 Gene

Sources for STC2 Gene

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