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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STC2 Gene

protein-coding   GIFtS: 57
GCID: GC05M172741

stanniocalcin 2
 Explore 17 diseases affiliated with
STC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STC2    

Aliases
for STC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Stanniocalcin 21 2
STC-21 2 3
Stanniocalcin-Related Protein2 3
STCRP2 3
STC-Related Protein2 3
Stanniocalcin-21

External Ids:    HGNC: 113741   Entrez Gene: 86142   Ensembl: ENSG000001137397   OMIM: 6036655   UniProtKB: O760613   

Export aliases for STC2 gene to outside databases

Previous GC identifers: GC05M173001 GC05M173443 GC05M172677 GC05M172722 GC05M172674 GC05M167836


Summaries
for STC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STC2:
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have
autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin
family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a
cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of
renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis.
Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction,
reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered
in some breast cancers. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STC2_HUMAN, O76061
Function: Has an anti-hypocalcemic action on calcium and phosphate homeostasis

Gene Wiki entry for STC2


Genomic Views
for STC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STC2 gene promoter:
         MAZR   STAT5A   HNF-4alpha1   Max   S8   E2F   POU2F1   POU2F1a   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.2

STC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STC2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M172741:  view genomic region     (about GC identifiers)

Start:
 172,741,716 bp from pter      End:
 172,756,506 bp from pter
Size:
 14,791 bases      Orientation:
 minus strand

Proteins
for STC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STC2_HUMAN, O76061 (See protein sequence)
Recommended Name: Stanniocalcin-2 precursor  
Size: 302 amino acids; 33249 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for STC2: NX_O76061

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O76061

    • STC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003705.1  
    ENSEMBL proteins: 
     ENSP00000265087   ENSP00000428470   ENSP00000427816  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): STC2
    OriGene Protein Over-expression Lysate: STC2
    OriGene Custom Protein Services for STC2 
    GenScript Custom Purified and Recombinant Proteins Services for STC2
    Novus Biologicals STC2 Protein
    Novus Biologicals STC2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for STC2
    Uscn Proteins for STC2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--


    STC2 for ontologies           About GeneDecksing



    STC2 Antibody Products: 
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    Uscn ELISAs and CLIAs for STC2

    Protein Domains /
    Families
    for STC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STC2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004978 Stanniocalcin

    Graphical View of Domain Structure for InterPro Entry O76061

    ProtoNet protein and cluster: O76061

    1 Blocks protein family: IPB004978 Stanniocalcin

    UniProtKB/Swiss-Prot: STC2_HUMAN, O76061
    Similarity: Belongs to the stanniocalcin family


    Function
    for STC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STC2_HUMAN, O76061
    Function: Has an anti-hypocalcemic action on calcium and phosphate homeostasis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STC2
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate STC2 (see all 58):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-140-5p hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-199a-3p hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmid: STC2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STC2 (see all 7)
    OriGene shRNA RFP: STC2
    OriGene siRNA: STC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STC2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STC2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STC2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STC2
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    GenScript: all cDNA clones in your preferred vector: STC2 (NM_003714)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STC2 

    Cell Line
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    Search LifeMap BioReagents cell lines for STC2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--


    STC2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STC2:
     Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-out Stc2tm1Rred for STC2
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Stc2):
     cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism  reproductive system 

    STC2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for STC2 (O760612, 3 ENSP000002650874) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIFM1O958312, 3, ENSP000002872954MINT-64403 I2D: score=5 STRING: ENSP00000287295
    ADAM11O750782, 3MINT-63200 I2D: score=5 
    ARHGEF40Q8TER52, 3MINT-65648 I2D: score=5 
    CARHSP1Q9Y2V22, 3MINT-65805 I2D: score=5 
    POLR2CP193872, 3MINT-63527 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0006979response to oxidative stress IEA--
    GO:0007166cell surface receptor signaling pathway TAS9753616
    GO:0007267cell-cell signaling TAS9753616
    GO:0007566embryo implantation IEA--


    STC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STC2

    1 HMDB Compound for STC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    4 Novoseek chemical compound relationships for STC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 37.9 8 18450365 (1), 11085516 (1), 17588736 (1), 10947959 (1) (see all 5)
    estrogen 31.6 11 11888893 (2), 17545519 (1), 18355956 (1), 14503913 (1) (see all 5)
    estradiol 22.5 4 15546506 (1), 15486227 (1), 11832417 (1)
    histidine 18.2 1 10450831 (1)

    Search CenterWatch for drugs/clinical trials and news about STC2 

    Transcripts
    for STC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STC2 gene: 
    NM_003714.2  

    Unigene Cluster for STC2:

    Stanniocalcin 2
    Hs.233160  [show with all ESTs]
    Unigene Representative Sequence: NM_003714
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265087(uc003mcn.1 uc003mco.1) ENST00000520593 ENST00000520648
    ENST00000518455 ENST00000519511

    miRNA
    Products:             		 OriGene 3'-UTR Clone: STC2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STC2
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate STC2 (see all 58):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-140-5p hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-199a-3p hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmid: STC2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STC2 (see all 7)
    OriGene shRNA RFP: STC2
    OriGene siRNA: STC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STC2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STC2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STC2 (NM_003714)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STC2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STC2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STC2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STC2

    Additional cDNA sequence: 

    AB012664.1 AF031036.1 AF055460.1 AF098462.1 AK027390.1 AK027663.1 AK075406.1 AK095862.1 
    AK095891.1 BC000658.2 BC006352.2 BC013958.2 BT019591.1 CR541825.1 

    13 DOTS entries:

    DT.95170242  DT.211309  DT.120874693  DT.100037258  DT.120874718  DT.120874720  DT.92438309  DT.97824991 
    DT.102826064  DT.95170240  DT.95170244  DT.97809118  DT.100794289 

    24/266 AceView cDNA sequences (see all 266):

    BX387388 AI093573 CR541825 AA298636 BC000658 AF031036 BQ000784 BP352011 
    BX090587 AW052188 BQ933537 BU539280 BP358421 CA488135 BF436533 BX363458 
    BQ928249 BP366084 AL701954 BX345117 CA442855 AA506021 BU624936 CR597612 

    GeneLoc Exon Structure


    Expression
    for STC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCGAGGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyBowman's CapsuleParietal Epithelial CellsKidney
    KidneyPodocyte LayerPresumptive PodocytesKidney
    KidneyS-shaped Body Proximal SegmentS-shaped Body Proximal CellsKidney
    LungRespiratory BronchiolesBasal CellsLung
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    KidneyBowman's CapsuleKidney
    KidneyGlomerular TuftKidney
    KidneyPodocyte LayerKidney
    KidneyS-shaped BodyKidney
    KidneyS-shaped Body Proximal SegmentKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See STC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STC2

    SOURCE GeneReport for Unigene cluster: Hs.233160

    UniProtKB/Swiss-Prot: STC2_HUMAN, O76061
    Tissue specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate,
    small intestine, colon and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for STC2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STC2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC2

    Orthologs
    for STC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for STC2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stc21 , 5 stanniocalcin 21, 5 84.35(n)1
    87.5(a)1    		   11 (18.40 cM)5
    208561  NM_011491.31  NP_035621.11 
     313573075 
    chicken
    (Gallus gallus)    		 Aves STC21 stanniocalcin 2 71.59(n)
    71.48(a)    		   416208  XM_414534.3  XP_414534.3 
    lizard
    (Anolis carolinensis)    		 Reptilia STC26
    		 --
    		 76(a)
    		 1 ↔ 1
    		 2(124766596-124774753)
    zebrafish
    (Danio rerio)    		 Actinopterygii stc2a1 stanniocalcin 2a 61.55(n)
    59.29(a)    		   544665  NM_001014827.1  NP_001014827.1 


    ENSEMBL Gene Tree for STC2 (if available)
    TreeFam Gene Tree for STC2 (if available) 

    Paralogs
    for STC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STC2 gene
    STC12  
    2 SIMAP similar genes for STC2 using alignment to 4 protein entries:     STC2_HUMAN (see all proteins):
    STC    STC1

    STC2 for paralogs           About GeneDecksing



    Genomic Variants
    for STC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/295 NCBI SNPs in STC2 are shown (see all 295)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1169776851,2
    		--172741350(+) GTTAAG/ACTGGT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1856995791,2
    		--172741597(+) ACTTCC/GTTCCC 1 -- ds50010--------
    rs1904148801,2
    		--172741615(+) TGAACA/GTCCAC 1 -- ds50010--------
    rs1138590831,2
    		C,--172741630(+) GCATAG/AGATTC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1503713921,2
    		--172741681(+) TGCACC/TGGACA 1 -- ds50010--------
    rs68955111,2
    		C,F,A,H,--172741710(+) AATGAC/TGCTAC 1 -- ds500110Minor allele frequency- T:0.14NS EA NA WA 1212
    rs1154414951,2
    		C,F,--172741772(+) ATGCAA/GTGTGA 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs785664321,2
    		C,--172741865(+) TCAGAC/TGGGGT 1 -- ut310--------
    rs1495677651,2
    		C,--172742069(+) GGCTA-/TTTATT 1 -- ut310--------
    rs1826854831,2
    		--172742219(+) AGGGTA/GTATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STC2 (172741716 - 172756506 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for STC2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STC2
    DNA2.0 Custom Variant and Variant Library Synthesis for STC2

    Disorders / Diseases
    for STC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STC2 for disorders           About GeneDecksing

    OMIM gene information: 603665    OMIM disorders: --

    17 diseases for STC2:    About MalaCards
    breast cancer    hypervitaminosis d    esophageal squamous cell carcinoma    squamous cell carcinoma
    renal cell carcinoma    fibrosarcoma    carcinoma    esophagitis
    ovarian cancer    gastric cancer    prostate carcinoma    colorectal cancer
    prostatitis    prostate cancer    hypoxia    neuroblastoma
    pancreatitis

    3 Novoseek disease relationships for STC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 29.6 19 18492817 (5), 17545519 (2), 18355956 (2), 11085516 (2) (see all 8)
    carcinoma renal cell 16 2 18450364 (1), 18450365 (1)
    tumors 8.98 25 18450365 (2), 11888893 (2), 19582875 (2), 19786016 (1) (see all 9)

    Human Genome Epidemiology (HuGE) Navigator: STC2 (2 documents)

    Export disorders for STC2 gene to outside databases

    Publications
    for STC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STC2 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with STC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a second human stanniocalcin homologue (STC2). (PubMed id 9753616)1, 2, 3, 9 Ishiabshi K.... Imai M. (1998)
    2. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. (PubMed id 9723890)1, 2, 3, 9 Chang A.C.-M. and Reddel R.R. (1998)
    3. Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. (PubMed id 10450831)1, 2, 9 Moore E.E.... de Jongh K.S. (1999)
    4. Molecular cloning and characterization of stanniocalcin-related protein. (PubMed id 10022771)1, 2, 9 DiMattia G.E.... Wagner G.F. (1998)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. (PubMed id 15486227)1, 9 Luo C.W....Hsueh A.J. (2005)
    7. Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. (PubMed id 18394600)1, 9 Law A.Y....Wong C.K. (2008)
    8. Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. (PubMed id 19786016)1, 9 Law A.Y. and Wong C.K. (2010)
    9. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. (PubMed id 10947959)1, 9 Jellinek D.A....Reddel R.R. (2000)
    10. Stanniocalcin 2 promotes invasion and is associated w ith metastatic stages in neuroblastoma. (PubMed id 19582875)1, 9 Volland S....Becker J. (2009)

    External Searches for STC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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    Genome Databases showing STC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8614 HGNC: 11374 AceView: STC2 Ensembl:ENSG00000113739 euGenes: HUgn8614
    ECgene: STC2 H-InvDB: STC2

    Other Databases showing STC2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STC2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for STC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STC2 gene:
    Search GeneIP for patents involving STC2

    GeneCards and IP:
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