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Aliases for STC2 Gene

Aliases for STC2 Gene

  • Stanniocalcin 2 2 3 5
  • Stanniocalcin-Related Protein 3 4
  • STC-Related Protein 3 4
  • STC-2 3 4
  • STCRP 3 4

External Ids for STC2 Gene

Previous GeneCards Identifiers for STC2 Gene

  • GC05M173001
  • GC05M173443
  • GC05M172677
  • GC05M172722
  • GC05M172674
  • GC05M172741
  • GC05M167836

Summaries for STC2 Gene

Entrez Gene Summary for STC2 Gene

  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for STC2 Gene

STC2 (Stanniocalcin 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is STC1.

UniProtKB/Swiss-Prot for STC2 Gene

  • Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

Gene Wiki entry for STC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STC2 Gene

Genomics for STC2 Gene

Regulatory Elements for STC2 Gene

Enhancers for STC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STC2 on UCSC Golden Path with GeneCards custom track

Promoters for STC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STC2 Gene

173,314,713 bp from pter
173,329,503 bp from pter
14,791 bases
Minus strand

Genomic View for STC2 Gene

Genes around STC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STC2 Gene

Proteins for STC2 Gene

  • Protein details for STC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for STC2 Gene

    302 amino acids
    Molecular mass:
    33249 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for STC2 Gene

Proteomics data for STC2 Gene at MOPED

Post-translational modifications for STC2 Gene

  • Glycosylation at Asn 73 and Thr 232
  • Modification sites at PhosphoSitePlus

Other Protein References for STC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for STC2 (Stanniocalcin 2/STC-2)

No data available for DME Specific Peptides for STC2 Gene

Domains & Families for STC2 Gene

Protein Domains for STC2 Gene


Suggested Antigen Peptide Sequences for STC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the stanniocalcin family.
  • Belongs to the stanniocalcin family.
genes like me logo Genes that share domains with STC2: view

No data available for Gene Families for STC2 Gene

Function for STC2 Gene

Molecular function for STC2 Gene

UniProtKB/Swiss-Prot Function:
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
genes like me logo Genes that share phenotypes with STC2: view

Animal Models for STC2 Gene

MGI Knock Outs for STC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for STC2

miRNA for STC2 Gene

miRTarBase miRNAs that target STC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STC2 Gene

Localization for STC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STC2 Gene


Subcellular locations from

Jensen Localization Image for STC2 Gene COMPARTMENTS Subcellular localization image for STC2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 22503972
genes like me logo Genes that share ontologies with STC2: view

Pathways & Interactions for STC2 Gene

SuperPathways for STC2 Gene

No Data Available

Interacting Proteins for STC2 Gene

Gene Ontology (GO) - Biological Process for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007566 embryo implantation IEA --
GO:0030968 endoplasmic reticulum unfolded protein response IEA --
GO:0033280 response to vitamin D IEA --
genes like me logo Genes that share ontologies with STC2: view

No data available for Pathways by source and SIGNOR curated interactions for STC2 Gene

Drugs & Compounds for STC2 Gene

(4) Drugs for STC2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with STC2: view

Transcripts for STC2 Gene

Unigene Clusters for STC2 Gene

Stanniocalcin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STC2 Gene

No ASD Table

Relevant External Links for STC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STC2 Gene

mRNA expression in normal human tissues for STC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STC2 Gene

This gene is overexpressed in Breast - Mammary Tissue (x7.3).

Protein differential expression in normal tissues from HIPED for STC2 Gene

This gene is overexpressed in Amniocyte (42.3), Plasma (14.6), and Serum (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STC2 Gene

SOURCE GeneReport for Unigene cluster for STC2 Gene Hs.233160

mRNA Expression by UniProt/SwissProt for STC2 Gene

Tissue specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with STC2: view

Protein tissue co-expression partners for STC2 Gene

- Elite partner

Primer Products

Orthologs for STC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STC2 35
  • 90.4 (n)
  • 91.06 (a)
STC2 36
  • 91 (a)
(Canis familiaris)
Mammalia STC2 35
  • 91.52 (n)
  • 92.73 (a)
STC2 36
  • 91 (a)
(Mus musculus)
Mammalia Stc2 35
  • 84.57 (n)
  • 87.5 (a)
Stc2 16
Stc2 36
  • 85 (a)
(Pan troglodytes)
Mammalia STC2 35
  • 99.45 (n)
  • 99.67 (a)
STC2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Stc2 35
  • 84.57 (n)
  • 85.81 (a)
(Monodelphis domestica)
Mammalia STC2 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia STC2 36
  • 89 (a)
(Gallus gallus)
Aves STC2 35
  • 71.25 (n)
  • 71.14 (a)
STC2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia STC2 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stc2 35
  • 65.09 (n)
  • 67.57 (a)
(Danio rerio)
Actinopterygii stc2a 35
  • 61.58 (n)
  • 59.93 (a)
stc2a 36
  • 58 (a)
stc2b 36
  • 46 (a)
Species with no ortholog for STC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STC2 Gene

Gene Tree for STC2 (if available)
Gene Tree for STC2 (if available)

Paralogs for STC2 Gene

Paralogs for STC2 Gene

(1) SIMAP similar genes for STC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STC2: view

Variants for STC2 Gene

Sequence variations from dbSNP and Humsavar for STC2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1135097 -- 173,316,557(-) AGAGA(C/G)AGAAC utr-variant-3-prime
rs1169277 -- 173,327,778(+) GCTTC(A/G)TTTCC intron-variant
rs6861507 -- 173,315,935(+) CAACC(A/G)CCGGC utr-variant-3-prime
rs6861827 -- 173,323,389(+) AGAGC(A/G)TGGGC reference, synonymous-codon
rs3756527 -- 173,331,171(-) TTATA(A/G)AGCTA upstream-variant-2KB

Variation tolerance for STC2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for STC2 Gene

Disorders for STC2 Gene

Relevant External Links for STC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STC2 Gene

Publications for STC2 Gene

  1. Molecular cloning of a second human stanniocalcin homologue (STC2). (PMID: 9753616) Ishiabshi K. … Imai M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. (PMID: 9723890) Chang A.C.-M. … Reddel R.R. (Mol. Cell. Endocrinol. 1998) 2 3 23
  3. Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. (PMID: 19786016) Law A.Y. … Wong C.K. (Exp. Cell Res. 2010) 3 23
  4. Stanniocalcin 2 overexpression in castration-resistant prostate cancer and aggressive prostate cancer. (PMID: 19298603) Tamura K. … Nakagawa H. (Cancer Sci. 2009) 3 23
  5. Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer. (PMID: 19415750) Ieta K. … Mori M. (Int. J. Cancer 2009) 3 23

Products for STC2 Gene

Sources for STC2 Gene