External Ids for STC1 Gene
Previous HGNC Symbols for STC1 Gene
Previous GeneCards Identifiers for STC1 Gene
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
GeneCards Summary for STC1 Gene
STC1 (Stanniocalcin 1) is a Protein Coding gene. Diseases associated with STC1 include fibrosarcoma and pheochromocytoma. GO annotations related to this gene include hormone activity. An important paralog of this gene is STC2.
UniProtKB/Swiss-Prot for STC1 Gene
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia