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Aliases for STC1 Gene

Aliases for STC1 Gene

  • Stanniocalcin 1 2 3 5
  • STC 3 4
  • Stanniocalcin-1 3
  • STC-1 4

External Ids for STC1 Gene

Previous HGNC Symbols for STC1 Gene

  • STC

Previous GeneCards Identifiers for STC1 Gene

  • GC08M023432
  • GC08M024052
  • GC08M023721
  • GC08M023755
  • GC08M022244
  • GC08M023700

Summaries for STC1 Gene

Entrez Gene Summary for STC1 Gene

  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for STC1 Gene

STC1 (Stanniocalcin 1) is a Protein Coding gene. GO annotations related to this gene include hormone activity. An important paralog of this gene is STC2.

UniProtKB/Swiss-Prot for STC1 Gene

  • Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Gene Wiki entry for STC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STC1 Gene

Genomics for STC1 Gene

Regulatory Elements for STC1 Gene

Enhancers for STC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F024152 1.3 FANTOM5 Ensembl ENCODE 12.5 -300.1 -300146 4.6 TBP CTCF TAF1 JUN MAX EBF1 RAD21 BRCA1 ZBTB40 RFX5 STC1 ENSG00000253891 LOC105379328
GH08F023796 1.3 FANTOM5 Ensembl ENCODE 12.3 +56.5 56522 3.0 GTF2F1 JUN MAX SIN3A ZIC2 HIC1 GLIS2 RCOR1 FOS KLF8 STC1 ENSG00000271118 LOC101929258
GH08F023880 0.8 Ensembl ENCODE 11.4 -26.6 -26564 0.8 SPI1 STC1 GC08P023881 GC08P023963
GH08F023828 0.4 ENCODE 11.4 +26.7 26735 0.1 MAX STC1 GC08M023807 ENSG00000207027
GH08F023891 0.8 Ensembl ENCODE 10.8 -37.8 -37848 1.7 ZNF654 KLF17 REST NFXL1 RAD21 NR2F2 SMARCA4 POLR2A SCRT2 IKZF1 STC1 NKX3-1 GC08P023881 GC08P023963
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STC1 on UCSC Golden Path with GeneCards custom track

Promoters for STC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001899448 507 2200 GTF2F1 TAF1 JUN SIN3A ZNF140 FEZF1 ZKSCAN1 ZNF316 GATA3 ZBTB48
ENSR00001899447 1907 201 MYNN EZH2

Genomic Location for STC1 Gene

Chromosome:
8
Start:
23,841,915 bp from pter
End:
23,854,807 bp from pter
Size:
12,893 bases
Orientation:
Minus strand

Genomic View for STC1 Gene

Genes around STC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STC1 Gene

Proteins for STC1 Gene

  • Protein details for STC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52823-STC1_HUMAN
    Recommended name:
    Stanniocalcin-1
    Protein Accession:
    P52823
    Secondary Accessions:
    • B4DN22
    • Q71UE5

    Protein attributes for STC1 Gene

    Size:
    247 amino acids
    Molecular mass:
    27621 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for STC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STC1 Gene

Post-translational modifications for STC1 Gene

  • Glycosylation at Asn 62, Thr 205, and Ser 237
  • Modification sites at PhosphoSitePlus

Other Protein References for STC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for STC1 (Stanniocalcin 1/STC-1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for STC1

No data available for DME Specific Peptides for STC1 Gene

Domains & Families for STC1 Gene

Protein Domains for STC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STC1 Gene

Graphical View of Domain Structure for InterPro Entry

P52823

UniProtKB/Swiss-Prot:

STC1_HUMAN :
  • Belongs to the stanniocalcin family.
Family:
  • Belongs to the stanniocalcin family.
genes like me logo Genes that share domains with STC1: view

No data available for Gene Families for STC1 Gene

Function for STC1 Gene

Molecular function for STC1 Gene

GENATLAS Biochemistry:
stanniocalcin,homolog of a calcium regulating hormone in bony fishes,putative regulator of mineral homeostasis,likely by stimulation of phosphate uptake by the renal tubule,expressed in both endochondral and membrane bone
UniProtKB/Swiss-Prot Function:
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Gene Ontology (GO) - Molecular Function for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with STC1: view
genes like me logo Genes that share phenotypes with STC1: view

Animal Models for STC1 Gene

MGI Knock Outs for STC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for STC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STC1 Gene

Localization for STC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STC1 Gene COMPARTMENTS Subcellular localization image for STC1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
mitochondrion 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA 12663264
GO:0005737 cytoplasm IDA 12663264
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with STC1: view

Pathways & Interactions for STC1 Gene

SuperPathways for STC1 Gene

No Data Available

Interacting Proteins for STC1 Gene

Selected Interacting proteins: P52823-STC1_HUMAN for STC1 Gene via IID

Gene Ontology (GO) - Biological Process for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001886 endothelial cell morphogenesis IDA 14500721
GO:0003421 growth plate cartilage axis specification IDA 16377640
GO:0006874 cellular calcium ion homeostasis IDA 8700837
GO:0007566 embryo implantation IEA --
genes like me logo Genes that share ontologies with STC1: view

No data available for Pathways by source and SIGNOR curated interactions for STC1 Gene

Drugs & Compounds for STC1 Gene

(9) Drugs for STC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for STC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STC1: view

Transcripts for STC1 Gene

mRNA/cDNA for STC1 Gene

Unigene Clusters for STC1 Gene

Stanniocalcin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STC1 Gene

No ASD Table

Relevant External Links for STC1 Gene

GeneLoc Exon Structure for
STC1
ECgene alternative splicing isoforms for
STC1

Expression for STC1 Gene

mRNA expression in normal human tissues for STC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STC1 Gene

This gene is overexpressed in Thyroid (x6.4) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for STC1 Gene

This gene is overexpressed in Cervix (51.6) and Milk (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of STC1 Gene:

STC1

SOURCE GeneReport for Unigene cluster for STC1 Gene:

Hs.25590

mRNA Expression by UniProt/SwissProt for STC1 Gene:

P52823-STC1_HUMAN
Tissue specificity: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.
genes like me logo Genes that share expression patterns with STC1: view

Primer Products

No data available for Protein tissue co-expression partners for STC1 Gene

Orthologs for STC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STC1 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia STC1 34 35
  • 94.47 (n)
cow
(Bos Taurus)
Mammalia STC1 34 35
  • 92.04 (n)
mouse
(Mus musculus)
Mammalia Stc1 34 16 35
  • 91.63 (n)
rat
(Rattus norvegicus)
Mammalia Stc1 34
  • 91.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STC1 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STC1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves STC1 34 35
  • 80.84 (n)
lizard
(Anolis carolinensis)
Reptilia STC1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stc1 34
  • 69.76 (n)
zebrafish
(Danio rerio)
Actinopterygii stc1 35
  • 57 (a)
OneToMany
stc1l 35
  • 51 (a)
OneToMany
zgc66061 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11504 34
Species where no ortholog for STC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STC1 Gene

ENSEMBL:
Gene Tree for STC1 (if available)
TreeFam:
Gene Tree for STC1 (if available)

Paralogs for STC1 Gene

Paralogs for STC1 Gene

(1) SIMAP similar genes for STC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STC1: view

Variants for STC1 Gene

Sequence variations from dbSNP and Humsavar for STC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10089975 -- 23,856,058(+) AAGGT(A/G)GTGAA upstream-variant-2KB
rs1062998 -- 23,844,559(-) TGTGA(C/T)CATTC utr-variant-3-prime
rs1063000 -- 23,843,048(-) GTGCT(C/T)GACTC utr-variant-3-prime
rs10638798 -- 23,842,485(+) CAGCC(-/AA)AAAAA utr-variant-3-prime
rs10643245 -- 23,845,563(+) TGTGT(-/TG)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STC1 Gene

Variant ID Type Subtype PubMed ID
esv3891377 CNV loss 25118596
nsv1028341 CNV gain 25217958
nsv831269 CNV gain 17160897

Variation tolerance for STC1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STC1 Gene

Disorders for STC1 Gene

Relevant External Links for STC1

Genetic Association Database (GAD)
STC1
Human Genome Epidemiology (HuGE) Navigator
STC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STC1

No disorders were found for STC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STC1 Gene

Publications for STC1 Gene

  1. Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. (PMID: 9480753) Chang A.C. … Reddel R.R. (Genomics 1998) 2 3 22 64
  2. Comparative analysis of mammalian stanniocalcin genes. (PMID: 9794484) Varghese R. … DiMattia G.E. (Endocrinology 1998) 3 4 22 64
  3. Human stanniocalcin: a possible hormonal regulator of mineral metabolism. (PMID: 8700837) Olsen H.S. … Wagner G.F. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  4. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for STC1 Gene

  • Cloud-Clone Corp. Antibodies for STC1
  • Cloud-Clone Corp. Proteins for STC1
  • Cloud-Clone Corp Assay Kits for STC1

Sources for STC1 Gene

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