Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STC1 Gene

Aliases for STC1 Gene

  • Stanniocalcin 1 2 3 5
  • STC 3 4
  • STC-1 4

External Ids for STC1 Gene

Previous HGNC Symbols for STC1 Gene

  • STC

Previous GeneCards Identifiers for STC1 Gene

  • GC08M023432
  • GC08M024052
  • GC08M023721
  • GC08M023755
  • GC08M022244
  • GC08M023700

Summaries for STC1 Gene

Entrez Gene Summary for STC1 Gene

  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for STC1 Gene

STC1 (Stanniocalcin 1) is a Protein Coding gene. Diseases associated with STC1 include Toxic Megacolon. GO annotations related to this gene include hormone activity. An important paralog of this gene is STC2.

UniProtKB/Swiss-Prot for STC1 Gene

  • Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Gene Wiki entry for STC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STC1 Gene

Genomics for STC1 Gene

Regulatory Elements for STC1 Gene

Enhancers for STC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STC1 on UCSC Golden Path with GeneCards custom track

Promoters for STC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for STC1 Gene

23,841,915 bp from pter
23,854,807 bp from pter
12,893 bases
Minus strand

Genomic View for STC1 Gene

Genes around STC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STC1 Gene

Proteins for STC1 Gene

  • Protein details for STC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DN22
    • Q71UE5

    Protein attributes for STC1 Gene

    247 amino acids
    Molecular mass:
    27621 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for STC1 Gene


neXtProt entry for STC1 Gene

Proteomics data for STC1 Gene at MOPED

Post-translational modifications for STC1 Gene

  • Glycosylation at Asn 62, Thr 205, and Ser 237
  • Modification sites at PhosphoSitePlus

Other Protein References for STC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for STC1 (Stanniocalcin 1/STC-1)

No data available for DME Specific Peptides for STC1 Gene

Domains & Families for STC1 Gene

Protein Domains for STC1 Gene


Suggested Antigen Peptide Sequences for STC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the stanniocalcin family.
  • Belongs to the stanniocalcin family.
genes like me logo Genes that share domains with STC1: view

No data available for Gene Families for STC1 Gene

Function for STC1 Gene

Molecular function for STC1 Gene

GENATLAS Biochemistry:
stanniocalcin,homolog of a calcium regulating hormone in bony fishes,putative regulator of mineral homeostasis,likely by stimulation of phosphate uptake by the renal tubule,expressed in both endochondral and membrane bone
UniProtKB/Swiss-Prot Function:
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
genes like me logo Genes that share phenotypes with STC1: view

Animal Models for STC1 Gene

MGI Knock Outs for STC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for STC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STC1 Gene

Localization for STC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STC1 Gene


Subcellular locations from

Jensen Localization Image for STC1 Gene COMPARTMENTS Subcellular localization image for STC1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
mitochondrion 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with STC1: view

Pathways & Interactions for STC1 Gene

SuperPathways for STC1 Gene

No Data Available

Interacting Proteins for STC1 Gene

Gene Ontology (GO) - Biological Process for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001886 endothelial cell morphogenesis IDA 14500721
GO:0010596 negative regulation of endothelial cell migration IDA 14500721
GO:0014070 response to organic cyclic compound IEA --
GO:0030336 negative regulation of cell migration IDA 17032941
genes like me logo Genes that share ontologies with STC1: view

No data available for Pathways by source and SIGNOR curated interactions for STC1 Gene

Drugs & Compounds for STC1 Gene

(8) Drugs for STC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for STC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STC1: view

Transcripts for STC1 Gene

mRNA/cDNA for STC1 Gene

Unigene Clusters for STC1 Gene

Stanniocalcin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STC1 Gene

No ASD Table

Relevant External Links for STC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STC1 Gene

mRNA expression in normal human tissues for STC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STC1 Gene

This gene is overexpressed in Thyroid (x6.4) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for STC1 Gene

This gene is overexpressed in Cervix (51.6) and Milk (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for STC1 Gene

SOURCE GeneReport for Unigene cluster for STC1 Gene Hs.25590

mRNA Expression by UniProt/SwissProt for STC1 Gene

Tissue specificity: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.
genes like me logo Genes that share expression patterns with STC1: view

Primer Products

No data available for Protein tissue co-expression partners for STC1 Gene

Orthologs for STC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STC1 35
  • 92.04 (n)
  • 95.14 (a)
STC1 36
  • 95 (a)
(Canis familiaris)
Mammalia STC1 35
  • 94.47 (n)
  • 98.38 (a)
STC1 36
  • 98 (a)
(Mus musculus)
Mammalia Stc1 35
  • 91.63 (n)
  • 96.36 (a)
Stc1 16
Stc1 36
  • 96 (a)
(Pan troglodytes)
Mammalia STC1 35
  • 99.6 (n)
  • 100 (a)
STC1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Stc1 35
  • 91.5 (n)
  • 95.95 (a)
(Monodelphis domestica)
Mammalia STC1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia STC1 36
  • 88 (a)
(Gallus gallus)
Aves STC1 35
  • 80.84 (n)
  • 87.45 (a)
STC1 36
  • 85 (a)
(Anolis carolinensis)
Reptilia STC1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stc1 35
  • 69.76 (n)
  • 70.8 (a)
(Danio rerio)
Actinopterygii zgc66061 35
stc1 36
  • 57 (a)
stc1l 36
  • 51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11504 35
Species with no ortholog for STC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STC1 Gene

Gene Tree for STC1 (if available)
Gene Tree for STC1 (if available)

Paralogs for STC1 Gene

Paralogs for STC1 Gene

(1) SIMAP similar genes for STC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STC1: view

Variants for STC1 Gene

Sequence variations from dbSNP and Humsavar for STC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7831701 -- 23,845,766(+) AGAAG(G/T)CTATT intron-variant
rs7841877 -- 23,850,522(+) GCCAC(A/G)CACAT intron-variant
rs9942746 -- 23,843,564(+) AAAGG(A/G)GACGA utr-variant-3-prime
rs9969426 -- 23,846,203(+) TTTAA(A/G)TACCC intron-variant
rs10089975 -- 23,856,058(+) AAGGT(A/G)GTGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STC1 Gene

Variant ID Type Subtype PubMed ID
nsv831269 CNV Gain 17160897

Variation tolerance for STC1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STC1 Gene

Disorders for STC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
toxic megacolon
  • megacolon, toxic
- elite association - COSMIC cancer census association via MalaCards
Search STC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with STC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STC1 Gene

Publications for STC1 Gene

  1. Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. (PMID: 9480753) Chang A.C. … Reddel R.R. (Genomics 1998) 2 3 23 67
  2. Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene. (PMID: 19628018) Law A.Y. … Wong C.K. (Mol. Cell. Endocrinol. 2010) 3 23
  3. Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells. (PMID: 20422040) Block G.J. … Prockop D.J. (PLoS ONE 2010) 3 23
  4. Stanniocalcin 1 and ovarian tumorigenesis. (PMID: 20484106) Liu G. … Liu J. (J. Natl. Cancer Inst. 2010) 3 23
  5. Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. (PMID: 19267325) Block G.J. … Prockop D.J. (Stem Cells 2009) 3 23

Products for STC1 Gene

Sources for STC1 Gene