STC1 Gene
protein-coding GIFtS : 53 GCID: GC08 M023700
stanniocalcin 1 STC )
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Aliasesfor STC1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Stanniocalcin 1 1 2 STC1 2 3 5 Stanniocalcin-11 STC-13
Export aliases for STC1 gene to outside databases Previous GC identifers: GC08M023432 GC08M024052 GC08M023721 GC08M023755 GC08M022244
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Summariesfor STC1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for STC1 : This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 Function : Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemiaGene Wiki entry for STC1
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Genomic Viewsfor STC1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_167187.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STC1 gene promoter:GR GR-beta Lmo2 Nkx2-5 NF-AT CREB NF-AT2 deltaCREB GR-alpha NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for STC1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STC1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8p21-p11.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p22-p12 STC1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M023700: view genomic region
(about GC identifiers )
Start: 23,699,428 bp from pter End:
23,712,320 bp from pter
Size: 12,893 bases Orientation:
minus strand
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Proteinsfor STC1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 See
protein sequence )Recommended Name: Size : 247 amino acids; 27621 DaSubunit : Homodimer; disulfide-linked (By similarity)Subcellular location : SecretedExplore the universe of human proteins at neXtProt for STC1: NX_P52823 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P52823 STC1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_003146.1 ENSEMBL proteins: ENSP00000290271 ENSP00000427932 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing STC1 Antibody Products: Assay Products for STC1:
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Protein
Domains /for STC1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry P52823 ProtoNet protein and cluster: P52823
1 Blocks protein family : IPB004978 UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 Similarity : Belongs to the stanniocalcin family
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Functionfor STC1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 Function : Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia
Genatlas biochemistry entry for STC1 stanniocalcin,homolog of a calcium regulating hormone in bony fishes,putative regulator of mineral homeostasis,likely by stimulation of phosphate uptake by the renal tubule,expressed in both endochondral and membrane bone Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STC1 (NM_003155 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STC1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005179 hormone activity
IEA --
About GeneDecksing Animal Models: Stc1 tm1Rred for STC14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stc1) :About GeneDecksing
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Pathways & Interactionsfor STC1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STC1 Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
About GeneDecksing
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Drugs & Compoundsfor STC1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for STC1 10/12 Novoseek chemical compound relationships for STC1 gene (see all 12 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
calcium
57.3
94
9458778 (5), 7829534 (5), 12663264 (4), 18828660 (3) (see all 40 )
progesterone
26.6
6
15131261 (4), 14512426 (1), 16391703 (1)
estradiol
5.83
3
15131261 (2), 11832417 (1)
gtp
4.37
1
17092635 (1)
dexamethasone
3.71
8
18187254 (3), 11739016 (1), 12933688 (1)
estrogen
1.28
4
18355956 (1), 15062564 (1), 14503913 (1)
atp
0
8
20422040 (4), 17092635 (2)
glucose
0
1
19389948 (1)
steroid
0
2
10854706 (1), 15476934 (1)
potassium
0
1
16640646 (1)
STC1
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Transcriptsfor STC1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for STC1 gene: NM_003155.2 Unigene Cluster for STC1:
Stanniocalcin 1 Hs.25590 [show with all ESTs ] Unigene Representative Sequence: U25997 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000290271 (uc003xdw.1 ) ENST00000524323 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: STC1 (NM_003155 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STC1
Additional cDNA sequence: AK297734.1 AK309366.1 AK312589.1 BC029044.1 S50179.1 S50184.1 U25997.1 U46768.1
3 DOTS entries : DT.413453 DT.203705
DT.100794624 24/186 AceView cDNA sequences (see all 186 ):
AI918535 BU729854 BE467088 BQ011910 AI702541 AI564094 AW771275 BM720350 AI245527 CD108782 CB265704 CA842388 BE219123 BM662722 CA842913 CB268374 AI521159 BM311087 CA434552 AI580273 BM686190 BQ000658 AI261899 BU732002 GeneLoc Exon Structure
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Expression for STC1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section STC1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTAATGACAG
About this image STC1 expression in embryonic tissues and stem cells About this table See STC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for STC1 SOURCE GeneReport for Unigene cluster: Hs.25590 UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 Tissue specificity : Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid.In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla SABiosciences Custom PCR Arrays for STC1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC1
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Orthologsfor STC1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for STC1 gene from 3/11 species (see all 11 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves STC11
stanniocalcin 1
80.84(n) 87.45(a)
428201 XM_425760.2 XP_425760.2
lizard Reptilia STC16
--
67(a)
1 ↔ 1
GL343422.1(68618-79216)
zebrafish Actinopterygii zgc660612
hypothetical protein MGC66061
73.53(n)
393511 BC056310.1
ENSEMBL Gene Tree for STC1 (if available)TreeFam Gene Tree for STC1 (if available)
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Paralogsfor STC1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for STC1 gene STC2 2 2 SIMAP similar genes for STC1 using alignment to 2 protein entries: STC1_HUMAN (see all proteins ):STC STC2 About GeneDecksing
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Genomic Variantsfor STC1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 8 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for STC1 (23699428 - 23712320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for STC1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor STC1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601185
OMIM disorders : --20/29 (see all 29 ): About MalaCards dwarfism breast cancer urethritis hypercalcemia ulcerative colitis fibrosarcoma pheochromocytoma constipation hepatocellular carcinoma breast carcinoma kidney disease carcinoma choroiditis colon cancer gastric cancer nasopharyngitis colorectal cancer lung cancer ischemia leukemia 1 disease from the University of Copenhagen DISEASES database for STC1 :Hypercalcemia 10/14 Novoseek disease relationships for STC1 gene (see all 14 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
hypercalcemia
58.6
10
8700837 (1), 9041047 (1), 12406069 (1), 11134638 (1) (see all 9 )
dwarfism
37.5
1
16377640 (1)
minimal residual disease
25.2
3
15383693 (2), 16637567 (1)
breast cancer
23
19
12684415 (6), 18355956 (2), 16637567 (1), 15062564 (1) (see all 8 )
fibrosarcoma
19
3
10947959 (3)
tumors
14.8
16
16109785 (3), 12684415 (2), 10717250 (2), 18355956 (1) (see all 11 )
pheochromocytoma
10.2
2
10937775 (1)
ovarian cancer
8.13
8
20484106 (3), 16109785 (1), 14503913 (1)
cancer
7.94
29
16109785 (3), 12684415 (3), 10717250 (3), 17395153 (3) (see all 12 )
metastasis
2.73
8
12684415 (1), 16330944 (1), 18355956 (1), 19515379 (1)
Human Genome Epidemiology (HuGE) Navigator: STC1 (5 documents) Export disorders for STC1 gene to outside databases
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Publicationsfor STC1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for STC1 gene, integrated from 9 sources (see all 122 ):(articles sorted by number of sources associating them with STC1) Utopia : connect your pdf to the dynamic
Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. (PubMed id 9480753) 1 , 3, 9(1998) Human stanniocalcin: a possible hormonal regulator of mineral metabolism. (PubMed id 8700837) 1 , 2 , 9(1996) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) A novel human cDNA highly homologous to the fish hormone stanniocalcin. (PubMed id 7489828) 1 , 2 (1995) Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. (PubMed id 15131261) 1 , 9(2004) Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. (PubMed id 18309109) 1 , 9(2008) Upregulated expression of stanniocalcin-1 during adipogenesis. (PubMed id 15149855) 1 , 9(2004) Stanniocalcin 1 and ovarian tumorigenesis. (PubMed id 20484106) 1 , 9(2010) Low-resolution structural studies of human Stanniocal cin-1. (PubMed id 19712479) 1 , 9(2009)
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External Searches for STC1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing STC1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing STC1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing STC1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for STC1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for STC1 gene: STC1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor STC1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for STC1 OriGene shRNA RFP for STC1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for STC1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for STC1 OriGene 3'-UTR Clone for STC1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for STC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for STC1 OriGene Custom Protein Services for STC1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STC1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STC1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for STC1
Recombinant Protein for STC1
STC1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC1
ThermoFisher Antibodies for STC1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat STC1
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Aliases for STC1
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Disorders / Diseases for STC1
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Drugs / Compounds for STC1
Expression for STC1
Function for STC1
Genomic Views for STC1
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Orthologs for STC1
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Pathways / Interactions for STC1
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Search Box for STC1
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Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
