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STC1 Gene

protein-coding   GIFtS: 55
GCID: GC08M023700

Stanniocalcin 1


(Previous symbol: STC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stanniocalcin 11 2
STC1 2 3 5
stanniocalcin-12
STC-13

External Ids:    HGNC: 113731   Entrez Gene: 67812   Ensembl: ENSG000001591677   OMIM: 6011855   UniProtKB: P528233   

Export aliases for STC1 gene to outside databases

Previous GC identifers: GC08M023432 GC08M024052 GC08M023721 GC08M023755 GC08M022244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STC1 Gene:
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have
autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded
protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its
serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate
transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in
mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered
expression in hepatocellular, ovarian, and breast cancers. (provided by RefSeq, Jul 2008)

GeneCards Summary for STC1 Gene:
STC1 (stanniocalcin 1) is a protein-coding gene. Diseases associated with STC1 include papillary tumour of the pineal region, and fibrosarcoma. GO annotations related to this gene include hormone activity. An important paralog of this gene is STC2.

UniProtKB/Swiss-Prot: STC1_HUMAN, P52823
Function: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia

Gene Wiki entry for STC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STC1 gene promoter:
         GR   GR-beta   Lmo2   Nkx2-5   NF-AT   CREB   NF-AT2   deltaCREB   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTC1 promoter sequence
   Search Chromatin IP Primers for STC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21-p11.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p22-p12

STC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M023700:  view genomic region     (about GC identifiers)

Start:
23,699,428 bp from pter      End:
23,712,320 bp from pter
Size:
12,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 (See protein sequence)
Recommended Name: Stanniocalcin-1 precursor  
Size: 247 amino acids; 27621 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Secondary accessions: Q71UE5

Explore the universe of human proteins at neXtProt for STC1: NX_P52823

Explore proteomics data for STC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn62, Thr205, Ser237
  • Modification sites at PhosphoSitePlus

  • See STC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003146.1  
    ENSEMBL proteins: 
     ENSP00000290271   ENSP00000427932  

    STC1 Human Recombinant Protein Products:

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    STC1 Antibody Products:

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    STC1 Assay Products:

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    Cloud-Clone Corp. ELISAs for STC1
    Cloud-Clone Corp. CLIAs for STC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004978 Stanniocalcin

    Graphical View of Domain Structure for InterPro Entry P52823

    ProtoNet protein and cluster: P52823

    1 Blocks protein domain: IPB004978 Stanniocalcin

    UniProtKB/Swiss-Prot: STC1_HUMAN, P52823
    Similarity: Belongs to the stanniocalcin family


    STC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STC1_HUMAN, P52823
    Function: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia

         Genatlas biochemistry entry for STC1:
    stanniocalcin,homolog of a calcium regulating hormone in bony fishes,putative regulator of mineral
    homeostasis,likely by stimulation of phosphate uptake by the renal tubule,expressed in both endochondral and
    membrane bone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    STC1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stc1):
     endocrine/exocrine gland  growth/size/body  normal  reproductive system 

    STC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stc1tm1Rred for STC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STC1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STC1

    miRNA
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    Block miRNA regulation of human, mouse, rat STC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STC1 (see all 58):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-146a hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSTC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STC1
    Predesigned siRNA for gene silencing in human, mouse, rat STC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: STC1 (NM_003155)
    Sino Biological Human cDNA Clone for STC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STC1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STC1_HUMAN, P52823: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    plasma membrane2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0016324apical plasma membrane IEA--

    STC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STC1
    Interactions:

        GeneGlobe Interaction Network for STC1

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006874cellular calcium ion homeostasis TAS8700837
    GO:0007166cell surface receptor signaling pathway TAS8700837
    GO:0007267cell-cell signaling TAS8700837
    GO:0007566embryo implantation IEA--

    STC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STC1

    Selected Novoseek inferred chemical compound relationships for STC1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 57.3 94 9458778 (5), 7829534 (5), 12663264 (4), 18828660 (3) (see all 40)
    progesterone 26.6 6 15131261 (4), 14512426 (1), 16391703 (1)
    estradiol 5.83 3 15131261 (2), 11832417 (1)
    gtp 4.37 1 17092635 (1)
    dexamethasone 3.71 8 18187254 (3), 11739016 (1), 12933688 (1)
    estrogen 1.28 4 18355956 (1), 15062564 (1), 14503913 (1)
    atp 0 8 20422040 (4), 17092635 (2)
    glucose 0 1 19389948 (1)
    steroid 0 2 10854706 (1), 15476934 (1)
    potassium 0 1 16640646 (1)



    STC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for STC1 gene: 
    NM_003155.2  

    Unigene Cluster for STC1:

    Stanniocalcin 1
    Hs.25590  [show with all ESTs]
    Unigene Representative Sequence: U25997
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290271(uc003xdw.1) ENST00000524323
    miRNA
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    Block miRNA regulation of human, mouse, rat STC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STC1 (see all 58):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-146a hsa-let-7a-2* hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSTC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STC1
    Predesigned siRNA for gene silencing in human, mouse, rat STC1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STC1 (NM_003155)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STC1
    Primer
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    OriGene qPCR primer pairs and template standards for STC1
    OriGene qSTAR qPCR primer pairs in human, mouse for STC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STC1
      QuantiTect SYBR Green Assays in human, mouse, rat STC1
      QuantiFast Probe-based Assays in human, mouse, rat STC1

    Additional mRNA sequence: 

    AK297734.1 AK309366.1 AK312589.1 BC029044.1 S50179.1 S50184.1 U25997.1 U46768.1 

    3 DOTS entries:

    DT.413453  DT.203705  DT.100794624 

    Selected AceView cDNA sequences (see all 186):

    AW136992 CA424042 BQ000658 CA842913 BM727706 BQ669764 AI367280 AI300520 
    CA455203 AI634794 AI625879 BM662762 BM720350 CB265704 BQ672018 CB126047 
    AI492382 BU729854 CA443951 BF434960 AI476245 AI245527 AI521159 BQ011910 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATGACAG
    STC1 Expression
    About this image


    STC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Fibroblasts (Uncategorized)
             Cardiac Fibroblasts Myocardium
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    STC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25590

    UniProtKB/Swiss-Prot: STC1_HUMAN, P52823
    Tissue specificity: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and
    thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and
    in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal
    medulla

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stc11 , 5 stanniocalcin 11, 5 91.63(n)1
    96.36(a)1
      14 (35.98 cM)5
    208551  NM_009285.31  NP_033311.31 
     690292895 
    chicken
    (Gallus gallus)
    Aves STC11 stanniocalcin 1 80.84(n)
    87.45(a)
      428201  XM_004947560.1  XP_004947617.1 
    lizard
    (Anolis carolinensis)
    Reptilia STC16
    stanniocalcin 1
    67(a)
    1 ↔ 1
    GL343422.1(68618-79216)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stc11 stanniocalcin 1 69.76(n)
    70.8(a)
      100497934  XM_002932554.2  XP_002932600.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc660612 hypothetical protein MGC66061 73.53(n)   393511  BC056310.1 


    ENSEMBL Gene Tree for STC1 (if available)
    TreeFam Gene Tree for STC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STC1 gene
    STC22  
    1 SIMAP similar gene for STC1 using alignment to 2 protein entries:     STC1_HUMAN (see all proteins):
    STC2

    STC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STC1 (see all 337)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349146851,2
    C--22252636(+) GAGAA-/GAATGG 1 -- int10--------
    rs106387981,2
    C--23699997(+) aaaaa-/A/AA  
            
    aaaaa
    2 -- ut31 trp32NA 4
    rs114113461,2
    C--23705668(+) ACACAT/-TTTTT 1 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs725773531,2
    C--23707492(+) TGAGA-/GAAAAT 1 -- int10--------
    rs590120391,2
    C--23709202(+) AAAAA-/AGCCCT 1 -- int10--------
    rs1117885421,2
    C--23709569(+) GTGTG-/TG    
       
    /TGTG
    CATGC
    1 -- int11CSA 2
    rs715498211,2
    C,F--23710548(+) TTAAA-/AAAG/AAAGAAAGAAA
    G
    /AAAGAAAGAAAGAAAG
    AAAGA
    2 -- int1 cds12NA CSA 4
    rs1421569391,2
    --23953328(+) AAGTAC/TTGAAG 1 -- int10--------
    rs1508677541,2
    --23953339(+) ATGCTA/GTTTTA 1 -- int10--------
    rs1910952081,2
    --23953390(+) CATCAC/TGCTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for STC1 (23699428 - 23712320 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831269CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STC1
    DNA2.0 Custom Variant and Variant Library Synthesis for STC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601185    OMIM disorders: --

    Selected diseases for STC1 (see all 34):    
    About MalaCards
    papillary tumour of the pineal region    fibrosarcoma    dwarfism    sporadic pheochromocytoma
    hypercalcemia    constipation    pheochromocytoma    urethritis
    esophageal squamous cell carcinoma    breast cancer    hypoxia    choroiditis
    ulcerative colitis    nasopharyngitis    kidney disease    endotheliitis
    ovarian cancer    esophagitis    neuroblastoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for STC1:
    Hypercalcemia

    STC1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for STC1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercalcemia 58.6 10 8700837 (1), 9041047 (1), 12406069 (1), 11134638 (1) (see all 9)
    dwarfism 37.5 1 16377640 (1)
    minimal residual disease 25.2 3 15383693 (2), 16637567 (1)
    breast cancer 23 19 12684415 (6), 18355956 (2), 16637567 (1), 15062564 (1) (see all 8)
    fibrosarcoma 19 3 10947959 (3)
    tumors 14.8 16 16109785 (3), 12684415 (2), 10717250 (2), 18355956 (1) (see all 11)
    pheochromocytoma 10.2 2 10937775 (1)
    ovarian cancer 8.13 8 20484106 (3), 16109785 (1), 14503913 (1)
    cancer 7.94 29 16109785 (3), 12684415 (3), 10717250 (3), 17395153 (3) (see all 12)
    metastasis 2.73 8 12684415 (1), 16330944 (1), 18355956 (1), 19515379 (1)

    Genetic Association Database (GAD): STC1
    Human Genome Epidemiology (HuGE) Navigator: STC1 (5 documents)

    Export disorders for STC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STC1 gene, integrated from 10 sources (see all 133):
    (articles sorted by number of sources associating them with STC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. (PubMed id 9480753)1, 3, 9 Chang A.C....Reddel R.R. (Genomics 1998)
    2. Comparative analysis of mammalian stanniocalcin genes. (PubMed id 9794484)1, 2, 9 Varghese R.... DiMattia G.E. (Endocrinology 1998)
    3. Human stanniocalcin: a possible hormonal regulator of mineral metabolism. (PubMed id 8700837)1, 2, 9 Olsen H.S....Wagner G.F. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    4. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A novel human cDNA highly homologous to the fish hormone stanniocalcin. (PubMed id 7489828)1, 2 Chang A.C.-M.... Reddel R.R. (Mol. Cell. Endocrinol. 1995)
    9. Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. (PubMed id 15131261)1, 9 Luo C.W....Hsueh A.J. (Mol. Endocrinol. 2004)
    10. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. (PubMed id 18309109)1, 9 Chen C....Yao Q. (Arterioscler. Thromb. Vasc. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6781 HGNC: 11373 AceView: STC1 Ensembl:ENSG00000159167 euGenes: HUgn6781
    ECgene: STC1 H-InvDB: STC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STC1 gene:
    Search GeneIP for patents involving STC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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