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Aliases for STBD1 Gene

Aliases for STBD1 Gene

  • Starch Binding Domain 1 2 3 5
  • Glycophagy Cargo Receptor STBD1 3 4
  • Genethonin 1 2 3
  • Starch-Binding Domain-Containing Protein 1 3
  • Genethonin-1 4
  • GENEX3414 3
  • GENX-3414 3

External Ids for STBD1 Gene

Previous GeneCards Identifiers for STBD1 Gene

  • GC04P077446
  • GC04P077227
  • GC04P072979
  • GC04P077173
  • GC04P077175

Summaries for STBD1 Gene

GeneCards Summary for STBD1 Gene

STBD1 (Starch Binding Domain 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Diurnally Regulated Genes with Circadian Orthologs. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and starch binding.

UniProtKB/Swiss-Prot for STBD1 Gene

  • Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.

Additional gene information for STBD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STBD1 Gene

Genomics for STBD1 Gene

GeneHancer (GH) Regulatory Elements for STBD1 Gene

Promoters and enhancers for STBD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I076304 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 566.7 +1.0 957 4.4 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 STBD1 CCDC158 SCARB2 FAM47E RNU6-1000P NUP54 GC04M076318 GC04M076287 FAM47E-STBD1
GH04I076299 Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.4 -4.5 -4519 3.4 PKNOX1 FOXA2 ARNT ZNF2 IRF4 YY1 ZNF766 CBX5 FOS JUNB STBD1 SCARB2 FAM47E CCDC158 FAM47E-STBD1 GC04M076287
GH04I076205 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.7 -95.2 -95232 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 FAM47E SCARB2 GC04P076210 NUP54 THAP6 SDAD1 ART3 NAAA G3BP2 STBD1
GH04I076377 Enhancer 1 Ensembl ENCODE 10.9 +71.6 71624 0.5 CTCF MEIS2 KLF1 PKNOX1 FOXA2 ZNF133 FEZF1 THRB HIC1 ZNF335 CCDC158 ENSG00000199857 RPL36AP18 RNU6-1000P STBD1 SCARB2 FAM47E SHROOM3 GC04M076357
GH04I076179 Enhancer 1 ENCODE dbSUPER 10.8 -126.0 -126003 0.1 FOXA2 RB1 RAD21 YY1 CHAMP1 ZNF121 ARID2 ZNF143 ATF7 RUNX3 NUP54 FAM47E SCARB2 CCDC158 STBD1 RNU6-1000P GC04P076210
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STBD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STBD1 gene promoter:

Genomic Locations for STBD1 Gene

Genomic Locations for STBD1 Gene
5,574 bases
Plus strand

Genomic View for STBD1 Gene

Genes around STBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STBD1 Gene

Proteins for STBD1 Gene

  • Protein details for STBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Starch-binding domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KVZ9

    Protein attributes for STBD1 Gene

    358 amino acids
    Molecular mass:
    39007 Da
    Quaternary structure:
    • Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (PubMed:20810658, PubMed:21893048). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (PubMed:24837458).

neXtProt entry for STBD1 Gene

Post-translational modifications for STBD1 Gene

Other Protein References for STBD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STBD1 Gene

Domains & Families for STBD1 Gene

Gene Families for STBD1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for STBD1 Gene

Suggested Antigen Peptide Sequences for STBD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.
  • The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.
  • The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.
genes like me logo Genes that share domains with STBD1: view

Function for STBD1 Gene

Molecular function for STBD1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.

Phenotypes From GWAS Catalog for STBD1 Gene

Gene Ontology (GO) - Molecular Function for STBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
GO:0019899 enzyme binding IPI 24837458
GO:0030246 carbohydrate binding IEA --
GO:0030247 polysaccharide binding IDA 24837458
GO:2001069 glycogen binding IDA 20810658
genes like me logo Genes that share ontologies with STBD1: view
genes like me logo Genes that share phenotypes with STBD1: view

miRNA for STBD1 Gene

miRTarBase miRNAs that target STBD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STBD1 Gene

Localization for STBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STBD1 Gene

Preautophagosomal structure membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Note=Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048). {ECO:0000269 PubMed:21893048, ECO:0000269 PubMed:9794794}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STBD1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 5
extracellular 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IGI 27358407
GO:0005783 endoplasmic reticulum IDA 9794794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with STBD1: view

Pathways & Interactions for STBD1 Gene

genes like me logo Genes that share pathways with STBD1: view

Pathways by source for STBD1 Gene

1 BioSystems pathway for STBD1 Gene
3 Reactome pathways for STBD1 Gene

Gene Ontology (GO) - Biological Process for STBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0005980 glycogen catabolic process IMP 20810658
GO:0006914 autophagy IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with STBD1: view

No data available for SIGNOR curated interactions for STBD1 Gene

Drugs & Compounds for STBD1 Gene

No Compound Related Data Available

Transcripts for STBD1 Gene

mRNA/cDNA for STBD1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(158) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STBD1 Gene

Starch binding domain 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STBD1 Gene

No ASD Table

Relevant External Links for STBD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STBD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STBD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STBD1 Gene

This gene is overexpressed in Lavage (29.5), Heart (6.7), and Liver (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STBD1 Gene

Protein tissue co-expression partners for STBD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of STBD1 Gene:


SOURCE GeneReport for Unigene cluster for STBD1 Gene:


mRNA Expression by UniProt/SwissProt for STBD1 Gene:

Tissue specificity: Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).

Evidence on tissue expression from TISSUES for STBD1 Gene

  • Muscle(4.5)
  • Liver(4.4)
  • Lung(4.2)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with STBD1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STBD1 Gene

Orthologs for STBD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STBD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STBD1 33 34
  • 99.26 (n)
(Bos Taurus)
Mammalia STBD1 33
  • 82.38 (n)
  • 70 (a)
(Canis familiaris)
Mammalia STBD1 33
  • 81.48 (n)
  • 66 (a)
(Rattus norvegicus)
Mammalia Stbd1 33
  • 79.36 (n)
(Mus musculus)
Mammalia Stbd1 33 16 34
  • 78.21 (n)
(Monodelphis domestica)
Mammalia FAM47E-STBD1 34
  • 47 (a)
(Gallus gallus)
Aves FAM47E-STBD1 34
  • 35 (a)
(Anolis carolinensis)
Reptilia FAM47E-STBD1 34
  • 21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17753 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1765 33
(Danio rerio)
Actinopterygii stbd1 34
  • 13 (a)
Species where no ortholog for STBD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STBD1 Gene

Gene Tree for STBD1 (if available)
Gene Tree for STBD1 (if available)

Paralogs for STBD1 Gene

(1) SIMAP similar genes for STBD1 Gene using alignment to 1 proteins: Pseudogenes for STBD1 Gene

genes like me logo Genes that share paralogs with STBD1: view

No data available for Paralogs for STBD1 Gene

Variants for STBD1 Gene

Sequence variations from dbSNP and Humsavar for STBD1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000182804 -- 76,305,194(+) A/T upstream_transcript_variant
rs1000466703 -- 76,308,295(+) T/A intron_variant
rs1000786600 -- 76,306,677(+) G/A 5_prime_UTR_variant
rs1000859234 -- 76,307,716(+) C/T intron_variant
rs1001119857 -- 76,308,912(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STBD1 Gene

Variant ID Type Subtype PubMed ID
esv3390912 CNV duplication 20981092
nsv7363 OTHER inversion 18451855

Variation tolerance for STBD1 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STBD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STBD1 Gene

Disorders for STBD1 Gene

Additional Disease Information for STBD1

No disorders were found for STBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STBD1 Gene

Publications for STBD1 Gene

  1. Molecular cloning and functional expression of a novel human gene encoding two 41-43 kDa skeletal muscle internal membrane proteins. (PMID: 9794794) Bouju S … Dechesne CA (The Biochemical journal 1998) 2 3 4 22 58
  2. The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein-protein interactions. (PMID: 24837458) Zhu Y … Cheng A (Bioscience reports 2014) 3 4 58
  3. Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1. (PMID: 21893048) Jiang S … Roach PJ (Biochemical and biophysical research communications 2011) 3 4 58
  4. Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism. (PMID: 20810658) Jiang S … Roach PJ (The Journal of biological chemistry 2010) 3 4 58
  5. Genome-wide association study reveals genetic risk underlying Parkinson's disease. (PMID: 19915575) Simón-Sánchez J … Gasser T (Nature genetics 2009) 3 44 58

Products for STBD1 Gene

Sources for STBD1 Gene

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