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STAU2 Gene

protein-coding   GIFtS: 56
GCID: GC08M074332

Staufen Double-Stranded RNA Binding Protein 2

(Previous names: staufen (Drosophila, RNA-binding protein) homolog 2, staufen,...)
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Aliases
for STAU2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Staufen Double-Stranded RNA Binding Protein 21 2     39K32
Staufen (Drosophila, RNA-Binding Protein) Homolog 21     Double-Stranded RNA-Binding Protein Staufen Homolog 22
Staufen, RNA Binding Protein, Homolog 2 (Drosophila)1     Staufen Homolog 22
39K22     Staufen, RNA Binding Protein, Homolog 22

External Ids:    HGNC: 113711   Entrez Gene: 270672   Ensembl: ENSG000000403417   OMIM: 6059205   UniProtKB: Q9NUL33   

Export aliases for STAU2 gene to outside databases

Previous GC identifers: GC08M073386 GC08M074273 GC08M074055 GC08M074382 GC08M074383 GC08M074495 GC08M069823


Summaries
for STAU2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAU2 Gene:
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the
transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins
are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having
double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and
human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies
of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for STAU2 Gene:
STAU2 (staufen double-stranded RNA binding protein 2) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU1.

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3
Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body
to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites
may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

Gene Wiki entry for STAU2 Gene


Genomic Views
for STAU2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAU2 gene promoter:
         GR   SREBP-1c   E2F-1   E2F   HOXA5   c-Myb   GR-alpha   En-1   RSRFC4   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAU2 promoter sequence
   Search Chromatin IP Primers for STAU2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAU2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

STAU2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAU2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M074332:  view genomic region     (about GC identifiers)

Start:
 74,332,604 bp from pter      End:
 74,659,943 bp from pter
Size:
 327,340 bases      Orientation:
 minus strand

Proteins
for STAU2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 (See protein sequence)
Recommended Name: Double-stranded RNA-binding protein Staufen homolog 2  
Size: 570 amino acids; 62641 Da
Subunit: Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules.
Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By
similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3,
PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1
Sequence caution: Sequence=BAA91766.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14522.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B7Z1I6 B7Z292 B7Z8B4 E7ER74 E9PEI3 E9PF26 E9PF50 Q6AHY7 Q96HM0 Q96HM1
Q9NVI5 Q9UGG6
Alternative splicing: 8 isoforms:  Q9NUL3-1   Q9NUL3-2   Q9NUL3-3   Q9NUL3-4   Q9NUL3-5   Q9NUL3-6   Q9NUL3-7   Q9NUL3-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAU2: NX_Q9NUL3

Explore proteomics data for STAU2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106
  • Modification sites at PhosphoSitePlus

    • See STAU2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001157852.1  NP_001157853.1  NP_001157854.1  NP_001157855.1  NP_001157856.1  NP_001157857.1  NP_055208.2  

    ENSEMBL proteins: 
     ENSP00000428456   ENSP00000428756   ENSP00000428741   ENSP00000429173   ENSP00000430511  
     ENSP00000348026   ENSP00000430907   ENSP00000429973   ENSP00000428476   ENSP00000427977  
     ENSP00000431111   ENSP00000428664   ENSP00000429005   ENSP00000428284   ENSP00000428829  
     ENSP00000430611   ENSP00000428681   ENSP00000428737  

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    Cloud-Clone Corp. Proteins for STAU2

         		 Search eBioscience for Proteins for STAU2 

         		antibodies-online proteins for STAU2 (5 products) 

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    antibodies-online kits for STAU2 (6 products) 

    Domains /
    Families
    for STAU2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    TryGeneCards Plus    		 1 InterPro protein domain:
     IPR014720 dsRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NUL3

    ProtoNet protein and cluster: Q9NUL3

    1 Blocks protein domain: IPB001159 Double-stranded RNA binding (DsRBD) domain

    UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3
    Domain: The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction
    with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)
    Similarity: Contains 4 DRBM (double-stranded RNA-binding) domains


    Find genes that share domains with STAU2           About GenesLikeMe


    Function
    for STAU2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAU2_HUMAN, Q9NUL3
    Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body
    to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites
    may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

         Genatlas biochemistry entry for STAU2:
    Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA--
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with STAU2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for STAU2:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for STAU2

    miRNA
    Products:            		miRTarBase miRNAs that target STAU2:
    hsa-mir-122-5p (MIRT023297)

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    Selected qRT-PCR Assays for microRNAs that regulate STAU2 (see all 18):
    hsa-miR-217 hsa-miR-3152-3p hsa-miR-499-5p hsa-miR-383 hsa-miR-7-1* hsa-miR-205* hsa-miR-23a hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: STAU2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STAU2

    Gene Editing
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    Localization
    for STAU2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAU2_HUMAN, Q9NUL3: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the
    nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the
    exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and
    XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in
    the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic
    reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These
    structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytoskeleton3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with STAU2           About GenesLikeMe


    Pathways & Interactions
    for STAU2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STAU2
    Interactions:

        Search GeneGlobe Interaction Network for STAU2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for STAU2 (Q9NUL31, 2, 3 ENSP000003480264) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1377Q9P2H02, 3MINT-65637 I2D: score=5 
    DHX58Q96C101, 3, ENSP000002516424EBI-722938,EBI-744193 I2D: score=1 STRING: ENSP00000251642
    EIF2AK2P195251, 3, ENSP000002330574EBI-722938,EBI-640775 I2D: score=1 STRING: ENSP00000233057
    KIF14ENSP000003563194STRING: ENSP00000356319
    NANOS1ENSP000003932754STRING: ENSP00000393275
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    Find genes that share ontologies with STAU2           About GenesLikeMe



    Drugs & Compounds
    for STAU2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for STAU2

    1 HMDB Compound for STAU2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    Transcripts
    for STAU2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAU2 gene (7 alternative transcripts): 
    NM_001164380.1  NM_001164381.1  NM_001164382.1  NM_001164383.1  NM_001164384.1  NM_001164385.1  NM_014393.2  

    Unigene Cluster for STAU2:

    Staufen, RNA binding protein, homolog 2 (Drosophila)
    Hs.561815  [show with all ESTs]
    Unigene Representative Sequence: NM_001164384
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000522695 ENST00000524300(uc011lfh.2 uc003xzn.3 uc003xzm.3 uc011lfg.2)
    ENST00000522818 ENST00000523558 ENST00000521210 ENST00000523533 ENST00000355780(uc003xzq.3 uc003xzp.3 uc011lfi.2)
    ENST00000519961(uc003xzo.3) ENST00000521727(uc010lzk.3) ENST00000521451
    ENST00000522509(uc010lzl.1) ENST00000517542 ENST00000518981 ENST00000518767
    ENST00000518502 ENST00000521293 ENST00000521447 ENST00000524104(uc003xzs.3 uc003xzr.3)

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    Selected qRT-PCR Assays for microRNAs that regulate STAU2 (see all 18):
    hsa-miR-217 hsa-miR-3152-3p hsa-miR-499-5p hsa-miR-383 hsa-miR-7-1* hsa-miR-205* hsa-miR-23a hsa-miR-103a-2*
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    Additional mRNA sequence: 

    AB210014.1 AF459097.1 AF459098.1 AK001576.1 AK002152.1 AK023314.1 AK126149.1 AK290141.1 
    AK293496.1 AK294466.1 AK303104.1 AK307841.1 AK314617.1 AL079285.1 AL079286.1 AL079288.1 
    BC008369.1 BC008370.1 BC071766.1 BC110447.1 BC110448.1 CR627442.1 Y19062.1 

    22 DOTS entries:

    DT.100793458  DT.211985  DT.97825785  DT.441481  DT.100793460  DT.121488555  DT.95219468  DT.100774335 
    DT.100793454  DT.95116497  DT.40122928  DT.95116508  DT.92440119  DT.40121513  DT.100693317  DT.454908 
    DT.92440123  DT.95116514  DT.121488516  DT.121488575  DT.100655650  DT.75194981 

    Selected AceView cDNA sequences (see all 446):

    NM_018299 BM272995 AK002152 BU178550 BC008369 BQ220156 Z40558 BM723081 
    CR618603 BX443603 BI553990 Z40600 BP339333 AW075627 CB851654 AA441931 
    AU143505 AI141962 BU754116 AW192087 BM836010 CF243154 BX538145 AW471368 

    GeneLoc Exon Structure


    Expression
    for STAU2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAU2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STAU2 Expression
    About this image

    STAU2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    STAU2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.561815
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    In Situ
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    Orthologs
    for STAU2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for STAU2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stau21 , 5 staufen (RNA binding protein) homolog 2 (Drosophila) less1, 5 90.99(n)1
    93.86(a)1    		   1 (5.05 cM)5
    298191  NM_025303.31  NP_079579.21 
     162286745 
    chicken
    (Gallus gallus)    		 Aves STAU21 staufen, RNA binding protein, homolog 2 (Drosophila) less 82.95(n)
    88.24(a)    		   420184  NM_001030941.1  NP_001026112.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STAU26
    		 staufen double-stranded RNA binding protein 2
    		 68(a)
    		 1 ↔ 1
    		 4(33551380-33770661)
    African clawed frog
    (Xenopus laevis)    		 Amphibia stau2-prov2 staufen, RNA binding protein, homolog 2 (Drosophila) less 76.78(n)    BC046732.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc552872 similar to staufen (RNA binding protein) homolog 2 (Drosophila) less 76.29(n)   393899  BC045292.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta stau6
    		 staufen
    		 19(a)
    		 1 → many
    		 2R(14005401-14013337)
    worm
    (Caenorhabditis elegans)    		 Secernentea stau-16
    		 Protein STAU-1 (stau-1) mRNA, complete cds
    		 24(a)
    		 1 → many
    		 X(1027671-1035244) WBGene00018857


    ENSEMBL Gene Tree for STAU2 (if available)
    TreeFam Gene Tree for STAU2 (if available)

    Paralogs
    for STAU2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAU2 gene
    STAU12  
    4 SIMAP similar genes for STAU2 using alignment to 14 protein entries:     STAU2_HUMAN (see all proteins):
    STAU2 variant protein    STAU1    PRKRA    TARBP2

    Find genes that share paralogs with STAU2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STAU2
    PGOHUM00000241438


    Genomic Variants
    for STAU2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAU2 (see all 5667)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1901038491,2
    		--74354313(+) GGCCAG/TGCGCA 4 -- int10--------
    rs1830917231,2
    		--74354350(+) TTTGGA/GAGGCC 4 -- int10--------
    rs1876859381,2
    		--74354456(+) TGGTGA/GCGGGT 4 -- int10--------
    rs1923527891,2
    		--74354457(+) GGTGGA/CGGGTG 4 -- int10--------
    rs1830014211,2
    		C--74354472(+) TAGTCC/G/TCAGCT 4 -- int10--------
    rs1489887931,2
    		--74354524(+) GTGGAA/GCTTGC 4 -- int10--------
    rs1434791381,2
    		C--74354567(+) CTGGGC/TGACAG 4 -- int10--------
    rs106066631,2
    		C--74354589(+) aaaaa-/A/A   
       A    /AAA    aaaaa     		8 -- int1 cds11NA 2
    rs608702631,2
    		C--74354609(+) AAAAA-/AA/AAA
                TTAAA     		8 -- int1 cds11NA 2
    rs801973581,2
    		C,F--74354693(+) ATCCTC/TATTAA 4 -- int11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for STAU2 (74332604 - 74582604 bp, first 250kb of STAU2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STAU2 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2327053CNV Deletion18987734
    esv2512239CNV Deletion19546169
    esv2670478CNV Deletion23128226
    esv2737166CNV Deletion23290073
    esv2664752CNV Deletion23128226
    esv2343023CNV Deletion18987734
    esv2737165CNV Deletion23290073
    esv2535782CNV Deletion19546169
    esv2737168CNV Deletion23290073
    esv2737167CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAU2
    DNA2.0 Custom Variant and Variant Library Synthesis for STAU2

    Disorders / Diseases
    for STAU2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 605920    OMIM disorders: --


    Find genes that share disorders with STAU2           About GenesLikeMe

    Genetic Association Database (GAD): STAU2

    Export disorders for STAU2 gene to outside databases

    Publications
    for STAU2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAU2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with STAU2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. (PubMed id 10585778)1, 2, 3 Buchner G.... Franco B. (Genomics 1999)
    2. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. (PubMed id 12140260)1, 2, 9 Duchaine T.F....DesGroseillers L. (J. Cell Sci. 2002)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. (PubMed id 23263869)1 Park E....Maquat L.E. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)

    External Searches for STAU2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing STAU2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 27067 HGNC: 11371 AceView: STAU2andFLJ11011 Ensembl:ENSG00000040341 euGenes: HUgn27067
    ECgene: STAU2 H-InvDB: STAU2

    Other Databases showing STAU2 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing STAU2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STAU2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STAU2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for STAU2 gene:
    Search GeneIP for patents involving STAU2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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