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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAU2 Gene

protein-coding GIFtS: 52
GCID: GC08M074332

staufen, RNA binding protein, homolog 2 (Drosophila)

(Previous names: staufen (Drosophila, RNA-binding protein) homolog 2 )

Explore 4 diseases affiliated with
STAU2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Staufen, RNA Binding Protein, Homolog 2 (Drosophila)¹ ²
39K2¹ ²
Staufen (Drosophila, RNA-Binding Protein) Homolog 2¹
39K3²
Double-Stranded RNA-Binding Protein Staufen Homolog 2²
Staufen Homolog 2²

External Ids:	HGNC: 11371¹	Entrez Gene: 27067²	Ensembl: ENSG00000040341⁷	OMIM: 605920⁵	UniProtKB: Q9NUL3³

Export aliases for STAU2 gene to outside databases

Previous GC identifers: GC08M073386 GC08M074273 GC08M074055 GC08M074382 GC08M074383 GC08M074495 GC08M069823

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAU2:

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport

and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized

by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary

structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The

exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it

could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have

been found for this gene. (provided by RefSeq, Aug 2009)

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3

Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to

the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be

a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

Gene Wiki entry for STAU2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAU2 gene promoter:
GR SREBP-1c E2F-1 E2F HOXA5 c-Myb GR-alpha En-1 RSRFC4 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAU2 promoter sequence

Search SABiosciences Chromatin IP Primers for STAU2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAU2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.11

STAU2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAU2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M074332: view genomic region (about GC identifiers)

Start:	74,332,604 bp from pter	End:	74,659,943 bp from pter
Size:	327,340 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 (See protein sequence)

Recommended Name: Double-stranded RNA-binding protein Staufen homolog 2

Size: 570 amino acids; 62641 Da

Subunit: Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform

2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity).

Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2,

STAU1, STAU2, SYNCRIP and YBX1

Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the

nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the

exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and

XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the

actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum.

Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are

thought to harbor housekeeping mRNAs when translation is aborted (By similarity)

Sequence caution: Sequence=BAA91766.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB14522.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B7Z1I6 B7Z292 B7Z8B4 E7ER74 E9PEI3 E9PF26 E9PF50 Q6AHY7 Q96HM0 Q96HM1 Q9NVI5

Q9UGG6

Alternative splicing: 8 isoforms: Q9NUL3-1 Q9NUL3-2 Q9NUL3-3 Q9NUL3-4 Q9NUL3-5 Q9NUL3-6 Q9NUL3-7 Q9NUL3-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAU2: NX_Q9NUL3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NUL3

STAU2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001157852.1 NP_001157853.1 NP_001157854.1 NP_001157855.1 NP_001157856.1 NP_001157857.1 NP_055208.2

ENSEMBL proteins:

ENSP00000428456 ENSP00000428756 ENSP00000428741 ENSP00000429173 ENSP00000430511

ENSP00000348026 ENSP00000430907 ENSP00000429973 ENSP00000428476 ENSP00000427977

ENSP00000431111 ENSP00000428664 ENSP00000429005 ENSP00000428284 ENSP00000428829

ENSP00000430611 ENSP00000428681 ENSP00000428737

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	Novus Biologicals STAU2 Proteins Novus Biologicals STAU2 Lysates
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	Uscn Proteins for STAU2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005730	nucleolus	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005874	microtubule	IEA	--

STAU2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for STAU2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAU2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001159 Ds-RNA-bd

IPR014720 dsRNA-bd-like_dom

Graphical View of Domain Structure for InterPro Entry Q9NUL3

ProtoNet protein and cluster: Q9NUL3

1 Blocks protein family: IPB001159 Double-stranded RNA binding (DsRBD) domain

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3

Domain: The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with

XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)

Similarity: Contains 4 DRBM (double-stranded RNA-binding) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3

Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to

the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be

a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

Genatlas biochemistry entry for STAU2:

Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation

miRNA Products:		OriGene 3'-UTR Clone (see all 7): STAU2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAU2
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate STAU2 (see all 18):
		hsa-miR-217 hsa-miR-3152-3p hsa-miR-499-5p hsa-miR-383 hsa-miR-7-1* hsa-miR-205* hsa-miR-23a hsa-miR-103a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: STAU2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAU2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	--	--
GO:0003725	double-stranded RNA binding	IEA	--
GO:0005515	protein binding	IPI	--

STAU2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for STAU2:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for STAU2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for STAU2 (Q9NUL3^{1, 2, 3} ENSP00000348026⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIAA1377	Q9P2H0²^,³	MINT-65637 I2D: score=5
DHX58	Q96C10¹^,³, ENSP00000251642⁴	EBI-722938,EBI-744193 I2D: score=1 STRING: ENSP00000251642
EIF2AK2	P19525¹^,³, ENSP00000233057⁴	EBI-722938,EBI-640775 I2D: score=1 STRING: ENSP00000233057
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--

STAU2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAU2

1 HMDB Compound for STAU2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about STAU2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAU2 gene (7 alternative transcripts):

NM_001164380.1 NM_001164381.1 NM_001164382.1 NM_001164383.1 NM_001164384.1 NM_001164385.1 NM_014393.2

Unigene Cluster for STAU2:

Staufen, RNA binding protein, homolog 2 (Drosophila)

Hs.561815 [show with all ESTs]

Unigene Representative Sequence: NM_001164384

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000522695 ENST00000524300(uc011lfh.2 uc003xzn.3 uc003xzm.3 uc011lfg.2)

ENST00000522818 ENST00000523558 ENST00000521210 ENST00000523533 ENST00000355780(uc003xzq.3 uc003xzp.3 uc011lfi.2)

ENST00000519961(uc003xzo.3) ENST00000521727(uc010lzk.3) ENST00000521451

ENST00000522509(uc010lzl.1) ENST00000517542 ENST00000518981 ENST00000518767

ENST00000518502 ENST00000521293 ENST00000521447 ENST00000524104(uc003xzs.3 uc003xzr.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 7): STAU2 Browse OriGene MicroRNA Expression Plasmids
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		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate STAU2 (see all 18):
		hsa-miR-217 hsa-miR-3152-3p hsa-miR-499-5p hsa-miR-383 hsa-miR-7-1* hsa-miR-205* hsa-miR-23a hsa-miR-103a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: STAU2 3' UTR sequence

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Additional cDNA sequence:

AB210014.1 AF459097.1 AF459098.1 AK001576.1 AK002152.1 AK023314.1 AK126149.1 AK290141.1

AK293496.1 AK294466.1 AK303104.1 AK307841.1 AK314617.1 AL079285.1 AL079286.1 AL079288.1

BC008369.1 BC008370.1 BC071766.1 BC110447.1 BC110448.1 CR627442.1 Y19062.1

22 DOTS entries:

DT.100793458 DT.211985 DT.97825785 DT.441481 DT.100793460 DT.121488555 DT.95219468 DT.100774335

DT.100793454 DT.95116497 DT.40122928 DT.95116508 DT.92440119 DT.40121513 DT.100693317 DT.454908

DT.92440123 DT.95116514 DT.121488516 DT.121488575 DT.100655650 DT.75194981

24/446 AceView cDNA sequences (see all 446):

F09321 AI741718 AW305281 BM818932 AW075627 AU133836 AL079288 AI768561

AI803713 BU159607 AA196389 BE889769 Z40558 BM723081 CD104313 AW235263

BU754116 CB160032 AI581093 D25755 CR609430 CD518764 AI802880 BQ067641

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAU2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

STAU2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STAU2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAU2

SOURCE GeneReport for Unigene cluster: Hs.561815

SABiosciences Custom PCR Arrays for STAU2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STAU2 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Stau2^{1 , 5}	staufen (RNA binding protein) homolog 2 (Drosophila) less^{1, 5}	90.99(n)¹ 93.86(a)¹		1 (5.05 cM)⁵ 29819¹ NM_025303.3¹ NP_079579.2¹ 16228674⁵
chicken (Gallus gallus)	Aves	STAU2¹	staufen, RNA binding protein, homolog 2 (Drosophila) less	82.95(n) 88.24(a)		420184 NM_001030941.1 NP_001026112.1
lizard (Anolis carolinensis)	Reptilia	STAU2⁶	--	78(a)	1 ↔ 1	4(33644939-33743024)
African clawed frog (Xenopus laevis)	Amphibia	stau2-prov²	staufen, RNA binding protein, homolog 2 (Drosophila) less	76.78(n)		BC046732.1
zebrafish (Danio rerio)	Actinopterygii	zgc55287²	similar to staufen (RNA binding protein) homolog 2 (Drosophila) less	76.29(n)		393899 BC045292.1
fruit fly (Drosophila melanogaster)	Insecta	stau¹	staufen	49.66(n) 43.99(a)		37065 NM_057403.3 NP_476751.1
worm (Caenorhabditis elegans)	Secernentea	stau-1¹	Protein STAU-1	44.13(n) 37.39(a)		180455 NM_075795.2 NP_508196.1

ENSEMBL Gene Tree for STAU2 (if available)
TreeFam Gene Tree for STAU2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAU2 gene

TARBP2² PRKRA² STAU1²

4 SIMAP similar genes for STAU2 using alignment to 14 protein entries: STAU2_HUMAN (see all proteins):

STAU2 variant protein STAU1 PRKRA TARBP2

STAU2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for STAU2
PGOHUM00000241438

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150669835^1,2		--	74332179(+)	`ACTGAC/TGGACT`	5	--	us2k¹ ds500¹		0	--	--	--	--
rs184151719^1,2		--	74332192(+)	`CCCACA/GTGGGA`	5	--	ds500¹ us2k¹		0	--	--	--	--
rs6998213^1,2	C,F,A,H,	--	74332207(+)	`TTAAAA/GACAAC`	5	--	ds500¹ us2k¹		31		EA NA NS WA CSA	2986
rs185969849^1,2		--	74332249(+)	`TTATTC/TTCCAG`	5	--	ds500¹ us2k¹		0	--	--	--	--
rs190687297^1,2		--	74332259(+)	`GTCGCA/GTGTGA`	5	--	ds500¹ us2k¹		0	--	--	--	--
rs183188190^1,2		--	74332265(+)	`TGTGAA/GTCAGC`	5	--	ds500¹ us2k¹		0	--	--	--	--
rs57122076^1,2	F,	--	74332283(+)	`TGATTT/CGTGGT`	5	--	ds500¹ us2k¹		3		WA NA EA	358
rs139930169^1,2		--	74332469(+)	`CAGTTG/TCTCAG`	5	--	ds500¹ nc-transcript-variant		0	--	--	--	--
rs187118704^1,2		--	74332694(+)	`CAACTC/TCAACA`	5	--	ut3¹ int¹		0	--	--	--	--
rs192977182^1,2		--	74332780(+)	`AAAAAC/TACTCT`	5	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for STAU2 (74332604 - 74582604 bp, first 250kb of STAU2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for STAU2
8 CNVs: 44359 65167 95497 95498 6637 100390 65166 100391
2 Indels: 47584 82643

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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STAU2 for disorders           About GeneDecksing

OMIM gene information: 605920    OMIM disorders: --

4 diseases for STAU2:    About MalaCards

becker muscular dystrophy muscular dystrophy immunodeficiency neuronitis

Export disorders for STAU2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for STAU2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with STAU2)

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Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. (PubMed id 10585778)^{1, 2, 3} Buchner G.... Franco B. (1999)
Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. (PubMed id 12140260)^{1, 2, 9} Duchaine T.F....DesGroseillers L. (2002)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S....Dorf M.E. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27067	HGNC: 11371	AceView: STAU2andFLJ11011	Ensembl:ENSG00000040341	euGenes: HUgn27067
ECgene: STAU2	H-InvDB: STAU2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAU2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STAU2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAU2 gene:
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GeneCards and IP:
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staufen, RNA binding protein, homolog 2 (Drosophila)

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STAU2 Gene

staufen, RNA binding protein, homolog 2 (Drosophila)

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