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STAU2 Gene

protein-coding GIFtS: 56
GCID: GC08M074332

Staufen Double-Stranded RNA Binding Protein 2

(Previous names: staufen (Drosophila, RNA-binding protein) homolog 2, staufen,...)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Staufen Double-Stranded RNA Binding Protein 2¹ ²		39K3²
Staufen (Drosophila, RNA-Binding Protein) Homolog 2¹		Double-Stranded RNA-Binding Protein Staufen Homolog 2²
Staufen, RNA Binding Protein, Homolog 2 (Drosophila)¹		Staufen Homolog 2²
39K2²		Staufen, RNA Binding Protein, Homolog 2²

External Ids:	HGNC: 11371¹	Entrez Gene: 27067²	Ensembl: ENSG00000040341⁷	OMIM: 605920⁵	UniProtKB: Q9NUL3³

Export aliases for STAU2 gene to outside databases

Previous GC identifers: GC08M073386 GC08M074273 GC08M074055 GC08M074382 GC08M074383 GC08M074495 GC08M069823

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAU2 Gene:

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the

transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins

are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having

double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and

human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies

of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for STAU2 Gene:

STAU2 (staufen double-stranded RNA binding protein 2) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU1.

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3

Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body

to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites

may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

Gene Wiki entry for STAU2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000008.10 NC_018919.2 NT_008183.20

Regulatory elements:

Regulatory transcription factor binding sites in the STAU2 gene promoter:
GR SREBP-1c E2F-1 E2F HOXA5 c-Myb GR-alpha En-1 RSRFC4 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAU2 promoter sequence

Search Chromatin IP Primers for STAU2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAU2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.11

STAU2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAU2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M074332: view genomic region (about GC identifiers)

Start:	74,332,604 bp from pter	End:	74,659,943 bp from pter
Size:	327,340 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 (See protein sequence)

Recommended Name: Double-stranded RNA-binding protein Staufen homolog 2

Size: 570 amino acids; 62641 Da

Subunit: Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules.

Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By

similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3,

PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1

Sequence caution: Sequence=BAA91766.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB14522.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B7Z1I6 B7Z292 B7Z8B4 E7ER74 E9PEI3 E9PF26 E9PF50 Q6AHY7 Q96HM0 Q96HM1

Q9NVI5 Q9UGG6

Alternative splicing: 8 isoforms: Q9NUL3-1 Q9NUL3-2 Q9NUL3-3 Q9NUL3-4 Q9NUL3-5 Q9NUL3-6 Q9NUL3-7 Q9NUL3-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAU2: NX_Q9NUL3

Explore proteomics data for STAU2 at MOPED

Post-translational modifications:

Ubiquitination² at Lys106

Modification sites at PhosphoSitePlus

See STAU2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (7 alternative transcripts):

NP_001157852.1 NP_001157853.1 NP_001157854.1 NP_001157855.1 NP_001157856.1 NP_001157857.1 NP_055208.2

ENSEMBL proteins:

ENSP00000428456 ENSP00000428756 ENSP00000428741 ENSP00000429173 ENSP00000430511

ENSP00000348026 ENSP00000430907 ENSP00000429973 ENSP00000428476 ENSP00000427977

ENSP00000431111 ENSP00000428664 ENSP00000429005 ENSP00000428284 ENSP00000428829

ENSP00000430611 ENSP00000428681 ENSP00000428737

STAU2 Human Recombinant Protein Products:

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	antibodies-online proteins for STAU2 (5 products)
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	antibodies-online kits for STAU2 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:

IPR014720 dsRNA-bd_dom

Graphical View of Domain Structure for InterPro Entry Q9NUL3

ProtoNet protein and cluster: Q9NUL3

1 Blocks protein domain: IPB001159 Double-stranded RNA binding (DsRBD) domain

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3

Domain: The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction

with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)

Similarity: Contains 4 DRBM (double-stranded RNA-binding) domains

Find genes that share domains with STAU2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STAU2_HUMAN, Q9NUL3

Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body

to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites

may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

Genatlas biochemistry entry for STAU2:

Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003725	double-stranded RNA binding	IDA	--
GO:0005515	protein binding	IPI	--
GO:0044822	poly(A) RNA binding	IDA	--

Find genes that share ontologies with STAU2 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for STAU2:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for STAU2

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		Selected qRT-PCR Assays for microRNAs that regulate STAU2 (see all 18):
		hsa-miR-217 hsa-miR-3152-3p hsa-miR-499-5p hsa-miR-383 hsa-miR-7-1* hsa-miR-205* hsa-miR-23a hsa-miR-103a-2*

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAU2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

STAU2_HUMAN, Q9NUL3: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the

nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the

exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and

XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in

the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic

reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These

structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
nucleus	5
cytoskeleton	3
cytosol	2

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005874	microtubule	IEA	--

Find genes that share ontologies with STAU2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for STAU2
Interactions:

Search GeneGlobe Interaction Network for STAU2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for STAU2 (Q9NUL3^{1, 2, 3} ENSP00000348026⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIAA1377	Q9P2H0²^,³	MINT-65637 I2D: score=5
DHX58	Q96C10¹^,³, ENSP00000251642⁴	EBI-722938,EBI-744193 I2D: score=1 STRING: ENSP00000251642
EIF2AK2	P19525¹^,³, ENSP00000233057⁴	EBI-722938,EBI-640775 I2D: score=1 STRING: ENSP00000233057
KIF14	ENSP00000356319⁴	STRING: ENSP00000356319
NANOS1	ENSP00000393275⁴	STRING: ENSP00000393275

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--

Find genes that share ontologies with STAU2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for STAU2

1 HMDB Compound for STAU2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for STAU2 gene (7 alternative transcripts):

NM_001164380.1 NM_001164381.1 NM_001164382.1 NM_001164383.1 NM_001164384.1 NM_001164385.1 NM_014393.2

Unigene Cluster for STAU2:

Staufen, RNA binding protein, homolog 2 (Drosophila)

Hs.561815 [show with all ESTs]

Unigene Representative Sequence: NM_001164384

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000522695 ENST00000524300(uc011lfh.2 uc003xzn.3 uc003xzm.3 uc011lfg.2)

ENST00000522818 ENST00000523558 ENST00000521210 ENST00000523533 ENST00000355780(uc003xzq.3 uc003xzp.3 uc011lfi.2)

ENST00000519961(uc003xzo.3) ENST00000521727(uc010lzk.3) ENST00000521451

ENST00000522509(uc010lzl.1) ENST00000517542 ENST00000518981 ENST00000518767

ENST00000518502 ENST00000521293 ENST00000521447 ENST00000524104(uc003xzs.3 uc003xzr.3)

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		hsa-miR-217 hsa-miR-3152-3p hsa-miR-499-5p hsa-miR-383 hsa-miR-7-1* hsa-miR-205* hsa-miR-23a hsa-miR-103a-2*

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Additional mRNA sequence:

AB210014.1 AF459097.1 AF459098.1 AK001576.1 AK002152.1 AK023314.1 AK126149.1 AK290141.1

AK293496.1 AK294466.1 AK303104.1 AK307841.1 AK314617.1 AL079285.1 AL079286.1 AL079288.1

BC008369.1 BC008370.1 BC071766.1 BC110447.1 BC110448.1 CR627442.1 Y19062.1

22 DOTS entries:

DT.100793458 DT.211985 DT.97825785 DT.441481 DT.100793460 DT.121488555 DT.95219468 DT.100774335

DT.100793454 DT.95116497 DT.40122928 DT.95116508 DT.92440119 DT.40121513 DT.100693317 DT.454908

DT.92440123 DT.95116514 DT.121488516 DT.121488575 DT.100655650 DT.75194981

Selected AceView cDNA sequences (see all 446):

NM_018299 BM272995 AK002152 BU178550 BC008369 BQ220156 Z40558 BM723081

CR618603 BX443603 BI553990 Z40600 BP339333 AW075627 CB851654 AA441931

AU143505 AI141962 BU754116 AW192087 BM836010 CF243154 BX538145 AW471368

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAU2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

STAU2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

STAU2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.561815

Custom PCR Arrays for STAU2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STAU2 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Stau2^{1 , 5}	staufen (RNA binding protein) homolog 2 (Drosophila) less^{1, 5}	90.99(n)¹ 93.86(a)¹		1 (5.05 cM)⁵ 29819¹ NM_025303.3¹ NP_079579.2¹ 16228674⁵
chicken (Gallus gallus)	Aves	STAU2¹	staufen, RNA binding protein, homolog 2 (Drosophila) less	82.95(n) 88.24(a)		420184 NM_001030941.1 NP_001026112.1
lizard (Anolis carolinensis)	Reptilia	STAU2⁶	staufen double-stranded RNA binding protein 2	68(a)	1 ↔ 1	4(33551380-33770661)
African clawed frog (Xenopus laevis)	Amphibia	stau2-prov²	staufen, RNA binding protein, homolog 2 (Drosophila) less	76.78(n)		BC046732.1
zebrafish (Danio rerio)	Actinopterygii	zgc55287²	similar to staufen (RNA binding protein) homolog 2 (Drosophila) less	76.29(n)		393899 BC045292.1
fruit fly (Drosophila melanogaster)	Insecta	stau⁶	staufen	19(a)	1 → many	2R(14005401-14013337)
worm (Caenorhabditis elegans)	Secernentea	stau-1⁶	Protein STAU-1 (stau-1) mRNA, complete cds	24(a)	1 → many	X(1027671-1035244) WBGene00018857

ENSEMBL Gene Tree for STAU2 (if available)
TreeFam Gene Tree for STAU2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for STAU2 gene

STAU1²

4 SIMAP similar genes for STAU2 using alignment to 14 protein entries: STAU2_HUMAN (see all proteins):

STAU2 variant protein STAU1 PRKRA TARBP2

Find genes that share paralogs with STAU2 About GenesLikeMe

1 Pseudogenes.org Pseudogene for STAU2
PGOHUM00000241438

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190103849^1,2		--	74354313(+)	`GGCCAG/TGCGCA`	4	--	int¹		0	--	--	--	--
rs183091723^1,2		--	74354350(+)	`TTTGGA/GAGGCC`	4	--	int¹		0	--	--	--	--
rs187685938^1,2		--	74354456(+)	`TGGTGA/GCGGGT`	4	--	int¹		0	--	--	--	--
rs192352789^1,2		--	74354457(+)	`GGTGGA/CGGGTG`	4	--	int¹		0	--	--	--	--
rs183001421^1,2	C	--	74354472(+)	`TAGTCC/G/TCAGCT`	4	--	int¹		0	--	--	--	--
rs148988793^1,2		--	74354524(+)	`GTGGAA/GCTTGC`	4	--	int¹		0	--	--	--	--
rs143479138^1,2	C	--	74354567(+)	`CTGGGC/TGACAG`	4	--	int¹		0	--	--	--	--
rs10606663^1,2	C	--	74354589(+)	`aaaaa-/A/A A/AAAaaaaa`	8	--	int¹ cds¹		1		NA	2
rs60870263^1,2	C	--	74354609(+)	`AAAAA-/AA/AAA TTAAA`	8	--	int¹ cds¹		1		NA	2
rs80197358^1,2	C,F	--	74354693(+)	`ATCCTC/TATTAA`	4	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for STAU2 (74332604 - 74582604 bp, first 250kb of STAU2)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for STAU2 (see all 22): About this table

Variant ID	Type	Subtype	PubMed ID
esv2327053	CNV	Deletion	18987734
esv2512239	CNV	Deletion	19546169
esv2670478	CNV	Deletion	23128226
esv2737166	CNV	Deletion	23290073
esv2664752	CNV	Deletion	23128226
esv2343023	CNV	Deletion	18987734
esv2737165	CNV	Deletion	23290073
esv2535782	CNV	Deletion	19546169
esv2737168	CNV	Deletion	23290073
esv2737167	CNV	Deletion	23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 605920 OMIM disorders: --

Find genes that share disorders with STAU2 About GenesLikeMe

Genetic Association Database (GAD): STAU2

Export disorders for STAU2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STAU2 gene, integrated from 10 sources (see all 39):
(articles sorted by number of sources associating them with STAU2)

Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. (PubMed id 10585778)^{1, 2, 3} Buchner G.... Franco B. (Genomics 1999)
Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. (PubMed id 12140260)^{1, 2, 9} Duchaine T.F....DesGroseillers L. (J. Cell Sci. 2002)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. (PubMed id 23263869)¹ Park E....Maquat L.E. (Proc. Natl. Acad. Sci. U.S.A. 2013)
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)¹ Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27067	HGNC: 11371	AceView: STAU2andFLJ11011	Ensembl:ENSG00000040341	euGenes: HUgn27067
ECgene: STAU2	H-InvDB: STAU2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAU2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STAU2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAU2 gene:
Search GeneIP for patents involving STAU2

GeneCards and IP:
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STAU2 Gene

Staufen Double-Stranded RNA Binding Protein 2

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Staufen Double-Stranded RNA Binding Protein 2

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