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STAU2 Gene(Protein Coding)

Staufen Double-Stranded RNA Binding Protein 2

GCID:
GC08M073386
GIFtS:
52
Genes Participants
UDN Logo

Aliases for STAU2 Gene

Aliases for STAU2 Gene

  • Staufen Double-Stranded RNA Binding Protein 2 2 3 5
  • Staufen, RNA Binding Protein, Homolog 2 (Drosophila) 2
  • Staufen (Drosophila, RNA-Binding Protein) Homolog 2 2
  • Staufen, RNA Binding Protein, Homolog 2 3
  • Staufen Homolog 2 3
  • 39K2 3
  • 39K3 3

External Ids for STAU2 Gene

Previous GeneCards Identifiers for STAU2 Gene

  • GC08M074273
  • GC08M074055
  • GC08M074382
  • GC08M074383
  • GC08M074495
  • GC08M074332
  • GC08M069823

Summaries for STAU2 Gene

Entrez Gene Summary for STAU2 Gene

  • Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for STAU2 Gene

STAU2 (Staufen Double-Stranded RNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is TARBP2.

UniProtKB/Swiss-Prot for STAU2 Gene

  • RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).

Gene Wiki entry for STAU2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAU2 Gene

Genomics for STAU2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for STAU2 Gene

Enhancers for STAU2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STAU2 on UCSC Golden Path with GeneCards custom track

Promoters for STAU2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STAU2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the STAU2 gene promoter:

Genomic Location for STAU2 Gene

Chromosome:
8
Start:
73,420,369 bp from pter
End:
73,747,708 bp from pter
Size:
327,340 bases
Orientation:
Minus strand

Genomic View for STAU2 Gene

Genes around STAU2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAU2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAU2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for STAU2 Gene

Proteins for STAU2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for STAU2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUL3-STAU2_HUMAN
    Recommended name:
    Double-stranded RNA-binding protein Staufen homolog 2
    Protein Accession:
    Q9NUL3
    Secondary Accessions:
    • B7Z1I6
    • B7Z292
    • B7Z8B4
    • E7ER74
    • E9PEI3
    • E9PF26
    • E9PF50
    • Q6AHY7
    • Q96HM0
    • Q96HM1
    • Q9NVI5
    • Q9UGG6

    Protein attributes for STAU2 Gene

    Size:
    570 amino acids
    Molecular mass:
    62641 Da
    Quaternary structure:
    • Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
    SequenceCaution:
    • Sequence=BAA91766.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14522.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for STAU2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAU2 Gene

Proteomics data for STAU2 Gene at MOPED

Protein Expression for STAU2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for STAU2 Gene

  • Ubiquitination at Lys 106
  • Modification sites at PhosphoSitePlus

Other Protein References for STAU2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STAU2 Gene

Domains & Families for STAU2 Gene

Protein Domains for STAU2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STAU2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUL3

UniProtKB/Swiss-Prot:

STAU2_HUMAN :
  • The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).
Domain:
  • The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).
  • Contains 4 DRBM (double-stranded RNA-binding) domains.
genes like me logo Genes that share domains with STAU2: view

No data available for Gene Families for STAU2 Gene

Function for STAU2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for STAU2 Gene

GENATLAS Biochemistry:
Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation
UniProtKB/Swiss-Prot Function:
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).

Phenotypes for STAU2 Gene

GenomeRNAi human phenotypes for STAU2:
genes like me logo Genes that share phenotypes with STAU2: view

miRNA for STAU2 Gene

miRTarBase miRNAs that target STAU2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAU2 Gene

Localization for STAU2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAU2 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAU2 Gene COMPARTMENTS Subcellular localization image for STAU2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for STAU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with STAU2: view

Pathways & Interactions for STAU2 Gene

SuperPathways for STAU2 Gene

PathCards logoMore details on SuperPathways for STAU2
No Data Available

Gene Ontology (GO) - Biological Process for STAU2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STAU2 Gene

Drugs & Compounds for STAU2 Gene

Products:

  1. Drug

(1) Drugs for STAU2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with STAU2: view

Transcripts for STAU2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for STAU2 Gene

(7) REFSEQ mRNAs :
(23) Additional mRNA sequences :
(446) Selected AceView cDNA sequences:
(29) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STAU2 Gene

Staufen, RNA binding protein, homolog 2 (Drosophila):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAU2 Gene

No ASD Table

Relevant External Links for STAU2 Gene

GeneLoc Exon Structure for
STAU2
ECgene alternative splicing isoforms for
STAU2

Expression for STAU2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for STAU2 Gene

mRNA expression in normal human tissues for STAU2 Gene
mRNA expression by BioGPS for STAU2 GenemRNA expression by GTEx for STAU2 Gene

Protein differential expression in normal tissues from HIPED for STAU2 Gene

This gene is overexpressed in Lung (52.6) and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAU2 Gene



SOURCE GeneReport for Unigene cluster for STAU2 Gene Hs.561815

genes like me logo Genes that share expression patterns with STAU2: view

Protein tissue co-expression partners for STAU2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STAU2 Gene

Orthologs for STAU2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAU2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia STAU2 35
  • 93.63 (n)
  • 95.88 (a)
STAU2 36
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia STAU2 35
  • 95.26 (n)
  • 96.49 (a)
STAU2 36
  • 96 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Stau2 35
  • 90.99 (n)
  • 93.86 (a)
Stau2 16
Stau2 36
  • 94 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia STAU2 35
  • 99.82 (n)
  • 99.65 (a)
rat
(Rattus norvegicus)
 Mammalia Stau2 35
  • 89.82 (n)
  • 92.46 (a)
oppossum
(Monodelphis domestica)
 Mammalia STAU2 36
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 73 (a)
 OneToMany
-- 36
  • 71 (a)
 OneToMany
-- 36
  • 25 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves STAU2 35
  • 82.95 (n)
  • 88.24 (a)
STAU2 36
  • 71 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia STAU2 36
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia stau2 35
  • 72.65 (n)
  • 73.42 (a)
Str.11080 35
African clawed frog
(Xenopus laevis)
 Amphibia stau2-prov 35
zebrafish
(Danio rerio)
 Actinopterygii stau2 35
  • 70.42 (n)
  • 73.94 (a)
zgc55287 35
stau2 36
  • 61 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007478 35
  • 52.01 (n)
  • 51.1 (a)
fruit fly
(Drosophila melanogaster)
 Insecta stau 36
  • 19 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea stau-1 36
  • 24 (a)
 OneToMany
Species with no ortholog for STAU2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAU2 Gene

ENSEMBL:
Gene Tree for STAU2 (if available)
TreeFam:
Gene Tree for STAU2 (if available)

Paralogs for STAU2 Gene

Paralogs for STAU2 Gene

(4) SIMAP similar genes for STAU2 Gene using alignment to 14 proteins:

Pseudogenes.org Pseudogenes for STAU2 Gene

genes like me logo Genes that share paralogs with STAU2: view

Variants for STAU2 Gene

Sequence variations from dbSNP and Humsavar for STAU2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs949493 - 73,615,761(+) ATCCA(C/T)ATCCT reference, missense
rs2062814 -- 73,642,455(+) gaggc(A/G)gaggt intron-variant
rs2128007 -- 73,727,663(+) atagt(A/G)atgct intron-variant
rs2128008 -- 73,727,664(+) tagta(A/C)tgcta intron-variant
rs2383905 -- 73,446,336(+) ctcat(G/T)gtgac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAU2 Gene

Variant ID Type Subtype PubMed ID
esv2737154 CNV Deletion 23290073
esv2671792 CNV Deletion 23128226
esv28754 CNV Loss 19812545
nsv524697 CNV Loss 19592680
nsv522502 CNV Loss 19592680
nsv6258 CNV Loss 18451855
nsv507473 CNV Insertion 20534489
esv270965 CNV Insertion 20981092
esv2664752 CNV Deletion 23128226
esv2535782 CNV Deletion 19546169
esv2737164 CNV Deletion 23290073
esv2737165 CNV Deletion 23290073
nsv395886 CNV Loss 16902084
esv23121 CNV Gain 19812545
esv2343023 CNV Deletion 18987734
esv2670478 CNV Deletion 23128226
esv2737166 CNV Deletion 23290073
esv2327053 CNV Deletion 18987734
esv2737167 CNV Deletion 23290073
esv2512239 CNV Deletion 19546169
esv2103697 CNV Deletion 18987734
esv2737168 CNV Deletion 23290073

Variation tolerance for STAU2 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STAU2 Gene

Disorders for STAU2 Gene

Relevant External Links for STAU2

Genetic Association Database (GAD)
STAU2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAU2

No disorders were found for STAU2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAU2 Gene

Publications for STAU2 Gene

  1. Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. (PMID: 10585778) Buchner G. … Franco B. (Genomics 1999) 2 3 4 67
  2. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. (PMID: 12140260) Duchaine T.F. … DesGroseillers L. (J. Cell Sci. 2002) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for STAU2 Gene

Sources for STAU2 Gene

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