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STAU2 Gene

protein-coding   GIFtS: 53

GC08M074332
staufen, RNA binding protein, homolog 2 (Drosophila)
(Previous names: staufen (Drosophila, RNA-binding protein) homolog 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
"" "" "" "" "" "" "" "" "" "" "" "" ""
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
staufen, RNA binding protein, homolog 2 (Drosophila)1 2     DKFZp781K03712
39K21 2     39K32
staufen (Drosophila, RNA-binding protein) homolog 21     MGC1196062
double-stranded RNA-binding protein Staufen homolog 22     staufen homolog 22

External Ids:    HGNC: 113711   Entrez Gene: 270672   Ensembl: ENSG000000403417   UniProtKB: Q9NUL33   

Search outside databases for aliases for STAU2 gene

Previous GC identifers: GC08M073386 GC08M074273 GC08M074055 GC08M074382 GC08M074383 GC08M074495

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAU2:
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport
and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized
by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary
structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The
exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it
could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3
Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to
the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be
a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

Gene Wiki entry for STAU2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the STAU2 gene upstream (promoter) region "":
FOXJ2 (long isoform)   SREBP-1c   SREBP-1b   SREBP-1a   E2F-1   E2F   GR-alpha   Hlf   RSRFC4   c-Myb   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for STAU2:  ""
MePH11628-2A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13-q21.1   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

STAU2 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M074332:  view genomic region     (about GC identifiers)

Start:
74,332,608 bp from pter
End:
74,659,075 bp from pter
Size:
326,468 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 (See protein sequence)
Recommended Name: Double-stranded RNA-binding protein Staufen homolog 2  
Size: 570 amino acids; 62641 Da
Subunit: Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform
2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity).
Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2,
STAU1, STAU2, SYNCRIP and YBX1
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the
nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the
exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and
XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the
actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum.
Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are
thought to harbor housekeeping mRNAs when translation is aborted (By similarity)
Sequence caution: Sequence=BAA91766.1; Type=Erroneous initiation; Sequence=BAB14522.1; Type=Erroneous initiation;
Secondary accessions: Q6AHY7 Q96HM0 Q96HM1 Q9NVI5 Q9UGG6
Alternative splicing: 5 isoforms:  Q9NUL3-1   Q9NUL3-2   Q9NUL3-3   Q9NUL3-4   Q9NUL3-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (7 alternative transcripts): 
    NP_001157852.1  NP_001157853.1  NP_001157854.1  NP_001157855.1  NP_001157856.1  NP_001157857.1  NP_055208.2  


    ENSEMBL proteins: 
    ENSP00000348026 ENSP00000344030 ENSP00000389932 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Browse recombinant and purified proteins available from Enzo Life Sciences
    ""HuPro® and/or Recombinant Proteins from Abnova for STAU2 ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Proteins for STAU2  ""
    Novus Biologicals Lysate for STAU2
    ""Browse Sino Biological Recombinant Proteins  ""

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005730 nucleolus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005783 endoplasmic reticulum IEA--
    About this table

    "" STAU2 for ontologies           About GeneDecksing



    Antibodies for STAU2: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for STAU2
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (STAU2)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for STAU2
    ""Browse antibodies at Epitomics

    Assays for STAU2: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Browse Enzo Life Sciences for kits & assays

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    "" STAU2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001159 Ds-RNA_bd
     IPR014720 dsRNA-bd-like

    Graphical View of Domain Structure for InterPro Entry Q9NUL3

    ProtoNet protein and cluster: Q9NUL3

    1 Blocks protein family: IPB001159 Double-stranded RNA binding (DsRBD) domain

    UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3
    Domain: The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with
    XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)
    Similarity: Contains 4 DRBM (double-stranded RNA-binding) domains

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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    Inhib.
    RNA:
    ""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (STAU2)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 7): STAU2
    Origene shRNA RFP (see all 7): STAU2
    Origene basic RS shRNA (see all 7): STAU2

    ""Applied Biosystems Silencer® siRNAs for STAU2
    ""Sigma-Aldrich siRNA for STAU2
    Sigma-Aldrich shRNA for STAU2
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 7): STAU2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): STAU2
    Origene untagged cDNA clones in CMV expression vector (see all 9): STAU2
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3
    Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to
    the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be
    a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)

    Genatlas biochemistry entry for STAU2:
    Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725 double-stranded RNA binding IEA--
    About this table

    "" STAU2 for ontologies           About GeneDecksing

    Animal Models: 2 MGI phenotypic alleles "" for Stau2 (no phenotypes)


    "" STAU2 for phenotypes           About GeneDecksing

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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    "" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STAU2

    1 Interacting protein for STAU2 (Q9NUL32) via UniProtKB, MINT, and/or STRING ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1377Q9P2H02MINT-65637
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport IEA--
    About this table

    "" STAU2 for ontologies           About GeneDecksing


    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

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    "" STAU2 for compounds           About GeneDecksing

    "" Browse drugs & compounds from Enzo Life Sciences
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for STAU2
    1 ""Novoseek chemical compound relationship for STAU2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    edta 1.27 1 12140260 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
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    Inhib.
    RNA:
    ""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (STAU2)
    ""Applied Biosystems Silencer® siRNAs:  NM_001164380  NM_001164381  NM_001164382  NM_001164383  NM_001164384  NM_001164385  NM_014393  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 7): STAU2
    Origene shRNA RFP (see all 7): STAU2
    Origene basic RS shRNA (see all 7): STAU2

    ""Sigma-Aldrich siRNA for STAU2
    Sigma-Aldrich shRNA for STAU2
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""1 SABiosciences microRNA that regulate STAU2""
    hsa-miR-139-5p
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_001164380  NM_001164381  NM_001164382  NM_001164383  NM_001164384  NM_001164385  NM_014393  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 7): STAU2
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): STAU2
    Origene untagged cDNA clones in CMV expression vector (see all 9): STAU2
    Primers:"" Origene genome-wide validated SYBR primer pairs: STAU2
    ""SABiosciences RT2 qPCR Primer Assay for STAU2: PPH23955A ""

    REFSEQ mRNAs for STAU2 gene (7 alternative transcripts): 

    NM_001164380.1  NM_001164381.1  NM_001164382.1  NM_001164383.1  NM_001164384.1  NM_001164385.1  NM_014393.2  

    Additional cDNA sequence: 

    AB210014.1 AF459097.1 AF459098.1 AK001576.1 AK001873.1 AK002152.1 AK021735.1 AK023314.1 
    AK024050.1 AK126149.1 AK225554.1 AK290141.1 AK293496.1 AK294466.1 AK295792.1 AK303104.1 
    AK307841.1 AK314617.1 AL079285.1 AL079286.1 AL079288.1 AL833723.1 AY948289.1 BC008369.1 
    BC008370.1 BC010900.1 BC016326.1 BC071766.1 BC110447.1 BC110448.1 BX538145.1 BX648427.1 
    CR457275.1 CR597814.1 CR609430.1 CR618603.1 CR627442.1 Y19062.1 

    24/30 DOTS entries (see all 30 ):

    DT.100640421  DT.100793458  DT.211985  DT.97825785  DT.100821509  DT.212257  DT.441481  DT.100793460 
    DT.102842  DT.121488555  DT.95219468  DT.100774335  DT.100793454  DT.95116497  DT.92440119  DT.40122928 
    DT.95116508  DT.100693317  DT.40121513  DT.95375728  DT.212259  DT.454908  DT.100821506  DT.92440123 

    24/446 AceView cDNA sequences (see all 446 ):

    AI741718 F09321 AW305281 CF243154 BQ432231 BC008369 BQ220156 BF448938 
    AA452968 AU130534 BC071766 BF061448 BM718979 BM979176 AA226963 BM682964 
    N51374 NM_001001482 AL710166 BM545397 BU150974 AK023314 CR597814 BM818932 

    "" highest scoring ESTs for STAU2:

    AA452968 AA918411 AI422858 AK002152 AL600984 AL705155 AL708648 BC008369 BC008370 BF574538 

    Unigene Cluster for STAU2:

    Staufen, RNA binding protein, homolog 2 (Drosophila)
    Hs.561815  [show with all ESTs]
    Unigene Representative Sequence: NM_001164384


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000355780  ENST00000343268  ENST00000418363  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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    STAU2 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for STAU2

    1""  / 2""  / 3""

    10 probe-sets matching STAU2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    49425_at2, 3 U95-B 1 1.00 1.00 0.89 1.19 AI422858 0.80 0.88 0.84 1
    84226_at2, 3 U95-D 1 1.00 1.00 0.87 1.09 AA452968 0.80 0.88 0.84 1
    38341_at2, 3 U95-A 1 0.94 1.00 -0.02 0.89 AL079286 0.60 0.83 0.73 1
    91498_at2, 3 U95-E 2 0.88 0.93 0.97 1.07 AA918411 0.80 0.88 0.84 1
    90206_at2, 3 U95-D 1 0.31 1.00 0.07 0.83 AI535972 0.40 1.00 0.76 1
    227179_at2, 3 U133-B 1 1.00 1.00 -- -- AK002152 0.80 0.88 0.84 1
    204226_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014393 0.60 0.83 0.73 1
    227179_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    204226_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1554686_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    "" STAU2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.561815

    Expression variation in blood from EXPOLDB for STAU2

    Primers:"" Origene genome-wide validated SYBR primer pairs: STAU2 ""
    ""SABiosciences RT2 qPCR Primer Assay for STAU2: PPH23955A ""
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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    Orthologs for STAU2 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    STAU21   -- staufen, RNA binding protein, homolog 2 (Drosophila) 95.75(n)
    98.54(a)
    477913  XM_844831.1  XP_849924.1 
    chimpanzee
    (Pan troglodytes)
    STAU21   -- staufen, RNA binding protein, homolog 2 (Drosophila) 99.58(n)
    99.37(a)
    464233  XM_001165116.1  XP_001165116.1 
    rat
    (Rattus norvegicus)
    Stau21   -- staufen, RNA binding protein, homolog 2 (Drosophila) 90.79(n)
    95.15(a)
    171500  NM_001007149.1  NP_001007150.1 
    mouse
    (Mus musculus)
    Stau21, 5 15
    staufen (RNA binding protein) homolog 2 (Drosophila)1, 5 90.61(n)1
    92.72(a)1
    298191  NM_025303.21  NP_079579.11 
     AF4590995  AF4591005  (see all 17)
    chicken
    (Gallus gallus)
    STAU21   -- staufen, RNA binding protein, homolog 2 (Drosophila) 81.83(n)
    87.57(a)
    420184  NM_001030941.1  NP_001026112.1 
    About this table        Species with no ortholog for STAU2

    ENSEMBL Gene Tree for STAU2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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    Paralogs for STAU2 gene
    TARBP22  PRKRAP12  STAU12  

    "" STAU2 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene


    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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    10/180 NCBI SNPs in STAU2 are shown (see all 180 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 225)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    ""
    rs9494931,2
    C,F,O,A,H70018665(+) ATCCAT/CATCCT 2 /M /V ref1 mis1 ese3""19Minor allele frequency- C:0.09MN NA NS EA WA 1566""
    --
    rs30881391,2
    C,F,A,H69953750(+) TGAAGG/TGAAAA 1 -- ut31 ese3""15Minor allele frequency- T:0.09MN NA NS EA WA 960""
    ""
    rs38086211,2
    C,F70150649(-) TAATAT/CTTTCG 1 -- ng51""12Minor allele frequency- C:0.05EA NS NA WA 2464""
    ""
    rs11321311,2
    C,F69953138(-) TAATAT/CACTCT 1 -- ut31""2Minor allele frequency- C:0.06MN WA 234""
    --
    rs45748381,2
    C69954047(+) ACTAAG/TAAATC 1 -- ut31""4Minor allele frequency- T:0.00NS EA 416""
    --
    rs69809141,2
    C74660977(+) caattC/Ttcctg 1 -- ng51""1Minor allele frequency- T:0.00NA 2""
    ""
    rs11321341,2
    C69952577(-) AATTTG/AATTTA 1 -- ut31""1Minor allele frequency- A:0.00MN 184""
    --
    rs43335891,2
    C69954171(+) AATAGA/GGGAAA 1 -- ut31 ese3 trp3""0--------
    ""
    rs69942621,2
    H70151178(+) AGTTCG/ATATTT 1 -- ng51""4Minor allele frequency- A:0.00NS EA 418""
    ""
    rs15667721,2
    C,F,O,A,H70080775(+) TACTAT/CAACAC 1 -- int1""25Minor allele frequency- C:0.38NS EA NA WA 1790""
    About this table

    HapMap Linkage Disequilibrium images for STAU2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 10 variations for STAU2
         8 CNVs: 44359 65167 95497 95498 6637 100390 65166 100391
         2 Indels: 47584 82643

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" STAU2 for disorders           About GeneDecksing

    OMIM: 605920

    2 ""Novoseek disease relationships for STAU2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    nuclear accumulation 2.04 1 15364930 (1)
    mental retardation 1.24 1 16809002 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
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      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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    10/22 PubMed articles for STAU2 gene (see all 22 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27067 HGNC: 11371 AceView: STAU2andFLJ11011 Ensembl:ENSG00000040341 euGenes: HUgn27067
    ECgene: STAU2 H-InvDB: STAU2
    (According to HUGE)
    About This Section

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      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for STAU2 gene: ""
    Search GeneIP for patents involving STAU2

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    ""
    ""
    Products for STAU2:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
     "" Free SNP selection tool

    ""
    "" Millipore Custom Antibody & Bulk Services
    "" Millipore Preclinical / Clinical Development Services
    "" Millipore Immunoassay Services
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    ""
    "" Predesigned and custom siRNAs for STAU2"" Antibodies for STAU2
    "" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
    "" Lentivirus-delivered shRNAs for STAU2"" Browse small molecules at Sigma-Aldrich
    "" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
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    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (STAU2)
    "" Antibodies (STAU2)
    "" Chimera RNAi (STAU2)
    "" Custom Service for Mouse Mab
    "" Custom Service for Rabbit Pab from Full-length Protein


    """"""""
    "" Search for Antibodies & Assays

    "" Tagged/untagged cDNA clones
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    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Search Tocris compounds for STAU2
    "" Regulatory tfbs in STAU2 upstream (promoter) region
    "" Search Chromatin IP Primers for STAU2
    "" DNA Methylation qPCR Primer Assays for STAU2
    "" RT2 qPCR Primer Assay for STAU2
    "" Search GNC Networks for STAU2
    "" microRNAs that regulate STAU2
    """"""""
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for STAU2
    "" Proteins for STAU2
    "" Lysates for STAU2
    "" Browse antibodies at Epitomics
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    "" Browse Sino Biological cDNA Clones
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
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    GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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