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Aliases & Descriptions for STAU2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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User Feedback Aliases & Descriptions staufen, RNA binding protein, homolog 2 (Drosophila)1 2 DKFZp781K03712 39K21 2 39K32 staufen (Drosophila, RNA-binding protein) homolog 21 MGC1196062 double-stranded RNA-binding protein Staufen homolog 22 staufen homolog 22
Search outside databases for aliases for STAU2 genePrevious GC identifers: GC08M073386 GC08M074273 GC08M074055 GC08M074382 GC08M074383 GC08M074495
Summaries for STAU2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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User Feedback Entrez Gene summary for STAU2 : Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq) UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 Function : RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body tothe dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity) Gene Wiki entry for STAU2
Genomic Views for STAU2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl (release 56) ,
Regulatory elements and Epigenetics data according to
SABiosciences )About This Section
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User Feedback Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STAU2 gene upstream (promoter) region :FOXJ2 (long isoform) SREBP-1c SREBP-1b SREBP-1a E2F-1 E2F GR-alpha Hlf RSRFC4 c-Myb Epigenetics: SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for STAU2: MePH11628-2A Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q13-q21.1 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.11 STAU2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M074332: view genomic region
(about GC identifiers )
Start:
74,332,608 bp from pter
End:
74,659,075 bp from pter
Size:
326,468 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000008.10 NT_008183.19 Proteins for STAU2 gene
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene ,
Novus Biologicals , and/or
Sino Biological ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 May 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abnova ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
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User Feedback UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 (See
protein sequence )Recommended Name: Double-stranded RNA-binding protein Staufen homolog 2 Size : 570 amino acids; 62641 Da
Subunit : Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1
Subcellular location : Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between thenucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity)
Sequence caution : Sequence=BAA91766.1; Type=Erroneous initiation; Sequence=BAB14522.1; Type=Erroneous initiation;
Secondary accessions : Q6AHY7 Q96HM0 Q96HM1 Q9NVI5 Q9UGG6Alternative splicing : 5 isoforms : Q9NUL3-1 Q9NUL3-2 Q9NUL3-3 Q9NUL3-4 Q9NUL3-5 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (7 alternative transcripts):
NP_001157852.1 NP_001157853.1 NP_001157854.1 NP_001157855.1 NP_001157856.1 NP_001157857.1 NP_055208.2 ENSEMBL proteins: ENSP00000348026 ENSP00000344030 ENSP00000389932 Human Recombinant Proteins 5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6
):
About this table
STAU2 for ontologies About GeneDecksing Antibodies for STAU2: Assays for STAU2:
Protein
Domains/ Families for STAU2 gene(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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STAU2 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NUL3 ProtoNet protein and cluster: Q9NUL3
1 Blocks protein family : IPB001159 Double-stranded RNA binding (DsRBD) domain UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 Domain : The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction withXPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity) Similarity : Contains 4 DRBM (double-stranded RNA-binding) domains
Gene Function for STAU2 gene
(According to MGI May 08 2010, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Millipore ,
Abnova ,
siRNAs from
Applied Biosystems ,
Sigma-Aldrich , Clones from
Millipore ,
Sigma-Aldrich ,
OriGene ,
Sino Biological ,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene .)
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User Feedback UniProtKB/Swiss-Prot: STAU2_HUMAN, Q9NUL3 Function : RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body tothe dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)
Genatlas biochemistry entry for STAU2 :Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation 1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003725 double-stranded RNA binding
IEA --
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STAU2 for ontologies About GeneDecksing Animal Models: 2 MGI phenotypic alleles for Stau2 (no phenotypes)
STAU2 for phenotypes About GeneDecksing Pathways & Interactions for STAU2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
Applied Biosystems GeneAssist ,
KEGG
and/or UniProtKB ,
(map by GeneGo ),
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene) .
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User Feedback Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STAU2 1 Interacting protein for STAU2 (Q9NUL3 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
IEA --
About this table
STAU2 for ontologies About GeneDecksing
Drugs & Compounds for STAU2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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STAU2 for compounds About GeneDecksing Browse Tocris compounds for STAU2 1 Novoseek chemical compound relationship for STAU2 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
edta
1.27
1
12140260 (1)
About this table
Transcripts for STAU2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 223 Homo sapiens; Apr 2 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Primers from
OriGene and/or
SABiosciences , Expression Assays from Applied Biosystems )About This Section
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User Feedback Assays: Applied Biosystems TaqMan® Gene Expression Assays: NM_001164380 NM_001164381 NM_001164382 NM_001164383 NM_001164384 NM_001164385 NM_014393 Clones: Origene GFP tagged cDNA clones in CMV expression vector (see all 7 ): STAU2 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7 ): STAU2 Origene untagged cDNA clones in CMV expression vector (see all 9 ): STAU2
Primers: Origene genome-wide validated SYBR primer pairs: STAU2 SABiosciences RT2 qPCR Primer Assay for STAU2: PPH23955A
REFSEQ mRNAs for STAU2 gene (7 alternative transcripts): NM_001164380.1 NM_001164381.1 NM_001164382.1 NM_001164383.1 NM_001164384.1 NM_001164385.1 NM_014393.2
Additional cDNA sequence: AB210014.1 AF459097.1 AF459098.1 AK001576.1 AK001873.1 AK002152.1 AK021735.1 AK023314.1 AK024050.1 AK126149.1 AK225554.1 AK290141.1 AK293496.1 AK294466.1 AK295792.1 AK303104.1 AK307841.1 AK314617.1 AL079285.1 AL079286.1 AL079288.1 AL833723.1 AY948289.1 BC008369.1 BC008370.1 BC010900.1 BC016326.1 BC071766.1 BC110447.1 BC110448.1 BX538145.1 BX648427.1 CR457275.1 CR597814.1 CR609430.1 CR618603.1 CR627442.1 Y19062.1
24/30 DOTS entries (see all 30
): DT.100640421 DT.100793458 DT.211985 DT.97825785 DT.100821509 DT.212257 DT.441481 DT.100793460
DT.102842 DT.121488555 DT.95219468 DT.100774335 DT.100793454 DT.95116497 DT.92440119 DT.40122928 DT.95116508 DT.100693317 DT.40121513 DT.95375728 DT.212259 DT.454908 DT.100821506 DT.92440123 24/446 AceView cDNA sequences (see all 446
):
AI741718 F09321 AW305281 CF243154 BQ432231 BC008369 BQ220156 BF448938 AA452968 AU130534 BC071766 BF061448 BM718979 BM979176 AA226963 BM682964 N51374 NM_001001482 AL710166 BM545397 BU150974 AK023314 CR597814 BM818932
highest scoring ESTs for STAU2 :AA452968 AA918411 AI422858 AK002152 AL600984 AL705155 AL708648 BC008369 BC008370 BF574538 Unigene Cluster for STAU2:
Staufen, RNA binding protein, homolog 2 (Drosophila) Hs.561815 [show with all ESTs ] Unigene Representative Sequence: NM_001164384 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000355780
ENST00000343268
ENST00000418363
Expression for STAU2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 223 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems ,
Primers from
OriGene and/or
SABiosciences
)
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User Feedback STAU2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for STAU2 1 / 2 / 3
10 probe-sets matching STAU2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
49425_at2 , 3
U95-B
1
1.00
1.00
0.89
1.19
AI422858
0.80
0.88
0.84
1
84226_at2 , 3
U95-D
1
1.00
1.00
0.87
1.09
AA452968
0.80
0.88
0.84
1
38341_at2 , 3
U95-A
1
0.94
1.00
-0.02
0.89
AL079286
0.60
0.83
0.73
1
91498_at2 , 3
U95-E
2
0.88
0.93
0.97
1.07
AA918411
0.80
0.88
0.84
1
90206_at2 , 3
U95-D
1
0.31
1.00
0.07
0.83
AI535972
0.40
1.00
0.76
1
227179_at2 , 3
U133-B
1
1.00
1.00
--
--
AK002152
0.80
0.88
0.84
1
204226_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_014393
0.60
0.83
0.73
1
227179_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
204226_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
1554686_at2
U133Plus2
1
0.27
1.00
--
--
--
--
--
--
--
About this table
STAU2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.561815 Expression variation in blood from EXPOLDB for STAU2
Primers: Origene genome-wide validated SYBR primer pairs: STAU2 SABiosciences RT2 qPCR Primer Assay for STAU2: PPH23955A
Orthologs for STAU2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI May 08 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for STAU2 gene from 5/9 species (see all 9
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
STAU21
--
staufen, RNA binding protein, homolog 2 (Drosophila)
95.75(n) 98.54(a)
477913 XM_844831.1 XP_849924.1
chimpanzee (Pan troglodytes)
STAU21
--
staufen, RNA binding protein, homolog 2 (Drosophila)
99.58(n) 99.37(a)
464233 XM_001165116.1 XP_001165116.1
rat (Rattus norvegicus)
Stau21
--
staufen, RNA binding protein, homolog 2 (Drosophila)
90.79(n) 95.15(a)
171500 NM_001007149.1 NP_001007150.1
mouse (Mus musculus)
Stau21 , 5
15
staufen (RNA binding protein) homolog 2 (Drosophila)1, 5
90.61(n) 1 92.72(a) 1
29819 1 NM_025303.2 1 NP_079579.1 1 AF459099 5 AF459100 5 (see all 17 )
chicken (Gallus gallus)
STAU21
--
staufen, RNA binding protein, homolog 2 (Drosophila)
81.83(n) 87.57(a)
420184 NM_001030941.1 NP_001026112.1
About this table Species with no ortholog for STAU2 ENSEMBL Gene Tree for STAU2 Paralogs for STAU2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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User Feedback Paralogs for STAU2 gene TARBP2 2 PRKRAP1 2 STAU1 2
STAU2 for paralogs About GeneDecksing Pseudogenes 1 related pseudogene
Genomic Variants for STAU2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for STAU2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 10 variations for STAU2 8 CNVs : 44359 65167 95497 95498 6637 100390 65166 100391 2 Indels : 47584 82643
Disorders & Mutations for STAU2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
BCGD,
and/or TGDB .)
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STAU2 for disorders About GeneDecksing
OMIM: 605920 2 Novoseek disease relationships for STAU2 gene
About this table
Medical News for STAU2 gene (Possibly Related Articles in
Doctor's Guide )
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User Feedback --
Publications for STAU2 gene (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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User Feedback 10/22 PubMed articles for STAU2 gene (see all 22
): Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. (PubMed id 10585778) 1, 2, 3 , 4 Buchner G.... Franco B. (1999) Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. (PubMed id 12140260) 1, 3 , 4 Duchaine T.F....DesGroseillers L. (2002) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3 , 4 Beausoleil S.A.... Gygi S.P. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3 , 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 , 4 Ota T....Sugano S. (2004) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330) 4 Gauci S....Mohammed S. (2009) Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303) 4 Weidensdorfer D....HA1ttelmaier S. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 4 Mayya V.... Han D.K. (2009) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008)
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User Feedback Patent Information for STAU2 gene: Search GeneIP for patents involving STAU2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search Services for STAU2 gene (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Novus Biologicals ,Epitomics , Sigma-Aldrich , R&D Systems , SABiosciences , Millipore , Abnova , Clones available from OriGene , Sigma-Aldrich , Sino Biological , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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