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STAU1 Gene

protein-coding   GIFtS: 56
GCID: GC20M047729

Staufen Double-Stranded RNA Binding Protein 1

(Previous names: staufen (Drosophila, RNA-binding protein), staufen, RNA...)
(Previous symbol: STAU)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Staufen Double-Stranded RNA Binding Protein 11 2     Staufen, RNA Binding Protein, Homolog 1 (Drosophila)1
STAU1 2 3 5     Double-Stranded RNA-Binding Protein Staufen Homolog 12
Staufen (Drosophila, RNA-Binding Protein)1     Staufen, RNA Binding Protein, Homolog 12
Staufen, RNA Binding Protein (Drosophila)1     

External Ids:    HGNC: 113701   Entrez Gene: 67802   Ensembl: ENSG000001242147   OMIM: 6017165   UniProtKB: O957933   

Export aliases for STAU1 gene to outside databases

Previous GC identifers: GC20M047164 GC20M044479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAU1 Gene:
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or
localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized
by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded
secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding
domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been
shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this
protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript
variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three
of these variants encode the same isoform, however, differ in their 5'UTR. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAU1 Gene:
STAU1 (staufen double-stranded RNA binding protein 1) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU2.

UniProtKB/Swiss-Prot: STAU1_HUMAN, O95793
Function: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific
positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in
stimulating their translation at the site

Gene Wiki entry for STAU1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAU1 gene promoter:
         AML1a   Olf-1   LUN-1   RelA   POU6F1 (c2)   NF-kappaB   MEF-2A   Ik-2   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAU1 promoter sequence
   Search Chromatin IP Primers for STAU1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1

STAU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAU1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M047729:  view genomic region     (about GC identifiers)

Start:
47,729,876 bp from pter      End:
47,804,904 bp from pter
Size:
75,029 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAU1_HUMAN, O95793 (See protein sequence)
Recommended Name: Double-stranded RNA-binding protein Staufen homolog 1  
Size: 577 amino acids; 63182 Da
Subunit: Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in
an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1,
HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with the influenza virus
nonstructural protein NS1
1 PDB 3D structure from and Proteopedia for STAU1:
4DKK (3D)    
Secondary accessions: A8K9Z4 E1P5Y1 E1P608 Q5JW29 Q6GTM4 Q9H5B4 Q9H5B5 Q9Y3Q2
Alternative splicing: 3 isoforms:  O95793-1   O95793-2   O95793-3   

Explore the universe of human proteins at neXtProt for STAU1: NX_O95793

Explore proteomics data for STAU1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STAU1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001032405.1  NP_004593.2  NP_059346.2  NP_059347.2  NP_059348.2  

    ENSEMBL proteins: 
     ENSP00000360922   ENSP00000353604   ENSP00000323443   ENSP00000345425   ENSP00000360867  
     ENSP00000360857   ENSP00000416779   ENSP00000398785   ENSP00000360893  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR014720 dsRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O95793

    ProtoNet protein and cluster: O95793

    1 Blocks protein domain: IPB001159 Double-stranded RNA binding (DsRBD) domain

    UniProtKB/Swiss-Prot: STAU1_HUMAN, O95793
    Domain: One of the DRDB could be involved in RER binding
    Domain: The C-terminal contains the tubulin binding domain (TBD) (By similarity)
    Similarity: Contains 3 DRBM (double-stranded RNA-binding) domains


    Find genes that share domains with STAU1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAU1_HUMAN, O95793
    Function: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific
    positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in
    stimulating their translation at the site

         Genatlas biochemistry entry for STAU1:
    Drosophila Staufen homolog 1,involved,in mRNA transport and localization

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IEA--
    GO:0005515protein binding IPI15121898
    GO:0008157protein phosphatase 1 binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with STAU1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAU1:
     Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stau1):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with STAU1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAU1
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    miRTarBase miRNAs that target STAU1:
    hsa-mir-16-5p (MIRT031669), hsa-mir-132-3p (MIRT021842), hsa-mir-30e-5p (MIRT044157), hsa-mir-27a-3p (MIRT028692), hsa-mir-877-5p (MIRT037250)

    Block miRNA regulation of human, mouse, rat STAU1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAU1 (see all 18):
    hsa-miR-142-5p hsa-miR-142-3p hsa-miR-181c hsa-miR-3150a-3p hsa-miR-330-3p hsa-miR-1208 hsa-miR-181b hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSTAU1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAU1_HUMAN, O95793: Cytoplasm. Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum
    endoplasmic (RER)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytoskeleton4
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19029303
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005875microtubule associated complex TAS10022909
    GO:0010494cytoplasmic stress granule ISS--
    GO:0030529ribonucleoprotein complex ----

    Find genes that share ontologies with STAU1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STAU1
    Interactions:

        GeneGlobe Interaction Network for STAU1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAU1 (O957931, 2, 3 ENSP000003609224) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q929001, 2, 3, ENSP000002628034EBI-358174,EBI-373471 MINT-8428273 I2D: score=3 STRING: ENSP00000262803
    CSNK2BP678702, 3MINT-8253649 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253649 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253649 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253649 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008298intracellular mRNA localization IEA--

    Find genes that share ontologies with STAU1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for STAU1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAU1 gene (5 alternative transcripts): 
    NM_001037328.1  NM_004602.2  NM_017452.2  NM_017453.2  NM_017454.2  

    Unigene Cluster for STAU1:

    Staufen, RNA binding protein, homolog 1 (Drosophila)
    Hs.596704  [show with all ESTs]
    Unigene Representative Sequence: NM_017453
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371856(uc002xud.3 uc002xug.3) ENST00000360426 ENST00000347458
    ENST00000340954(uc002xua.3 uc002xuc.3 uc002xue.3) ENST00000371802
    ENST00000371792 ENST00000437404 ENST00000456866 ENST00000371828(uc002xub.3 uc002xuf.3)

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    Selected qRT-PCR Assays for microRNAs that regulate STAU1 (see all 18):
    hsa-miR-142-5p hsa-miR-142-3p hsa-miR-181c hsa-miR-3150a-3p hsa-miR-330-3p hsa-miR-1208 hsa-miR-181b hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSTAU1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): STAU1 (NM_004602)
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      QuantiFast Probe-based Assays in human, mouse, rat STAU1

    Additional mRNA sequence: 

    AB209561.1 AF061938.1 AF061939.1 AF061940.1 AF061941.1 AJ132258.1 AK025519.1 AK057739.1 
    AK091405.1 AK291487.1 AK292859.1 AK298372.1 AL136601.2 AY529074.1 AY546099.1 BC000830.1 
    BC001893.1 BC007532.1 BC010169.2 BC050432.1 BC095397.1 

    Selected DOTS entries (see all 37):

    DT.92449625  DT.100827903  DT.418633  DT.95293366  DT.95325331  DT.92449630  DT.100827909  DT.101983819 
    DT.120795743  DT.100827898  DT.120795501  DT.120795675  DT.95243773  DT.100827899  DT.120795655  DT.100648489 
    DT.100658186  DT.95184160  DT.100760788  DT.100827904  DT.100827905  DT.120795605  DT.120795628  DT.120795694 

    Selected AceView cDNA sequences (see all 454):

    AI123136 BM968612 BQ649508 T30766 AW166420 AA157806 CA429519 BM142141 
    BM994617 AI917566 AI802592 BC001893 BM471665 BM751736 AA907298 BQ772722 
    AI362641 AA043331 BQ639627 AI983007 BQ225193 BU622917 BI855643 AA903609 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAU1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:        -     -     -                 -     -                                         -                       -                                             
    SP2:                    -                 -     -                                         -                       -                                             
    SP3:                    -           -     -     -                                                                 -                                             
    SP4:                    -           -     -     -                                         -                       -                                             
    SP5:                                -     -     -                                                                                                               


    ECgene alternative splicing isoforms for STAU1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGTAAGT
    STAU1 Expression
    About this image


    STAU1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    STAU1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAU1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596704

    UniProtKB/Swiss-Prot: STAU1_HUMAN, O95793
    Tissue specificity: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney
    and placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAU1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STAU1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stau11 , 5 staufen (RNA binding protein) homolog 1 (Drosophila)1, 5 87.12(n)1
    91.41(a)1
      2 (87.22 cM)5
    208531  NM_001109906.11  NP_001103376.11 
     1669475495 
    chicken
    (Gallus gallus)
    Aves STAU16
    Gallus gallus staufen, RNA binding protein, homolo...
    73(a)
    1 ↔ 1
    20(6780571-6803177)
    lizard
    (Anolis carolinensis)
    Reptilia STAU16
    staufen double-stranded RNA binding protein 1
    72(a)
    1 ↔ 1
    4(146412016-146455224)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3989372 hypothetical protein LOC398937 78.88(n)    BC060382.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stau16
    staufen, RNA binding protein, homolog 1 (Drosophil...
    59(a)
    1 ↔ 1
    6(46369038-46392004) ENSDARG00000044182
    fruit fly
    (Drosophila melanogaster)
    Insecta stau6
    staufen
    18(a)
    1 → many
    2R(14005401-14013337)
    worm
    (Caenorhabditis elegans)
    Secernentea stau-16
    Protein STAU-1 (stau-1) mRNA, complete cds
    21(a)
    1 → many
    X(1027671-1035244) WBGene00018857


    ENSEMBL Gene Tree for STAU1 (if available)
    TreeFam Gene Tree for STAU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAU1 gene
    STAU22  
    3 SIMAP similar genes for STAU1 using alignment to 5 protein entries:     STAU1_HUMAN (see all proteins):
    STAU2    STAU2 variant protein    TARBP2

    Find genes that share paralogs with STAU1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for STAU1
    PGOHUM00000234180


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAU1 (see all 1746)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390018401,2
    --47700418(+) TTCAGC/TTATTC 5 -- ds50010--------
    rs1498843001,2
    --47700457(+) AGTGAA/CGCCTT 5 -- ds50010--------
    rs1829934421,2
    --47700482(+) ACTTCC/TTCTAA 5 -- ds50010--------
    rs1465024771,2
    --47700567(+) GGTGAA/GAGATG 5 -- ds50010--------
    rs1131088031,2
    F--47700636(+) GGTAGC/TAATGT 5 -- ds50012Minor allele frequency- T:0.03CSA WA 120
    rs1878864481,2
    --47700717(+) GAGGGA/GCTGGC 5 -- ds50010--------
    rs1447965091,2
    C--47700776(+) TTTTA-/AGTTAC 5 -- ds50010--------
    rs1913047431,2
    --47700845(+) AAAGTA/TATTTC 5 -- ut310--------
    rs2022040531,2
    --47700902(+) TTTTT-/CTTAAA 5 -- ut310--------
    rs1117206641,2
    C--47700936(+) TTGGGA/G/TGGGGA 10 -- ut311CSA 1

    HapMap Linkage Disequilibrium report for STAU1 (47729876 - 47804904 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STAU1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435739CNV Deletion17901297
    esv2670489CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAU1
    DNA2.0 Custom Variant and Variant Library Synthesis for STAU1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601716    OMIM disorders: --


    Find genes that share disorders with STAU1           About GenesLikeMe


    Export disorders for STAU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAU1 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with STAU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. (PubMed id 15680326)1, 3, 9 Kim Y.K....Maquat L.E. (Cell 2005)
    2. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. (PubMed id 8884277)1, 3, 9 DesGroseillers L. and Lemieux N. (Genomics 1996)
    3. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D.... Huettelmaiery S. (RNA 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. (PubMed id 10325410)1, 2 Falcon A.M.... Ortin J. (Nucleic Acids Res. 1999)
    9. Mammalian Staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum. (PubMed id 10022909)1, 2 Wickham L.... DesGroseillers L. (Mol. Cell. Biol. 1999)
    10. The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. (PubMed id 18498651)1, 9 Chatel-Chaix L....Desgroseillers L. (Retrovirology 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6780 HGNC: 11370 AceView: STAU Ensembl:ENSG00000124214 euGenes: HUgn6780
    ECgene: STAU1 H-InvDB: STAU1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STAU1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAU1 gene:
    Search GeneIP for patents involving STAU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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