STATH Gene
protein-coding GIFtS: 51
GCID: GC04P070861
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|
statherin
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Aliases for STATH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
Export aliases for STATH gene to outside databasesPrevious GC identifers: GC04P070771 GC04P070910 GC04P071112 GC04P071177 GC04P071042 GC04P066659 |
Summaries for STATH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: STAT_HUMAN, P02808Function: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation ofcalcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface Gene Wiki entry for STATH
|
Genomic Views for STATH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the STATH gene promoter: Nkx3-1 v2 CREB Nkx3-1 v4 p53 deltaCREB Nkx3-1 v3 Nkx3-1 v1 Other transcription factors
Search SABiosciences Chromatin IP Primers for STATH
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STATH |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.3 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3STATH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P070861: view genomic region
(about GC identifiers)
Start:
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70,861,647 bp from pter |
End:
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70,868,287 bp from pter |
Size:
|
6,641 bases |
Orientation:
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plus strand |
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Proteins for STATH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: STAT_HUMAN, P02808 (See
protein sequence)Recommended Name: Statherin precursor Size: 62 amino acids; 7304 Da
Subcellular location: Secreted
Mass spectrometry: Mass=5380.0; Mass_error=0.3; Method=Electrospray; Range=20-62; Note=With phosphorylated Ser-21 andSer-22; Source=PubMed:17313100;
Mass spectrometry: Mass=5363.0; Mass_error=0.3; Method=Electrospray; Range=20-62; Note=With phosphorylated Ser-21 andSer-22 and transglutamine cross-link; Source=PubMed:17313100;
Secondary accessions: A6NKE9 B2R4F8Alternative splicing: 2 isoforms: P02808-1 P02808-2 Explore the universe of human proteins at neXtProt for STATH: NX_P02808
Post-translational modifications:
Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% iscyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva1
Sulfated on tyrosine residues1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P02808 STATH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001009181.1 NP_003145.1 ENSEMBL proteins: ENSP00000246895 ENSP00000370448 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
STATH for ontologies About GeneDecksing
STATH Antibody Products: Assay Products for STATH: |
Protein
Domains / Families for STATH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STATH for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P02808ProtoNet protein and cluster: P02808 UniProtKB/Swiss-Prot: STAT_HUMAN, P02808Similarity: Belongs to the histatin/statherin family |
Function for STATH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: STAT_HUMAN, P02808Function: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation ofcalcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface Genatlas biochemistry entry for STATH:statherin,salivary small acidic protein,calcium binding
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STATH (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STATH (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): STATH (NM_001009181) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STATH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STATH  |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
STATH for ontologies About GeneDecksing
|
Pathways & Interactions for STATH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Gastric acid secretion | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for STATH):
STATH for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STATH
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5 Interacting proteins for STATH (P028081, 3 ENSP000002468954) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
STATH for ontologies About GeneDecksing
|
Drugs & Compounds for STATH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STATH for compounds About GeneDecksing
Browse Tocris compounds for STATH
1 HMDB Compound for STATH About this table 10/12 Novoseek chemical compound relationships for STATH gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydroxyapatite |
80.3 |
94 |
16634639 (4), 18054952 (4), 1313424 (4), 19678690 (3) (see all 34) |
| trifluoroethanol |
36.3 |
2 |
1718282 (1), 9048421 (1) |
| proline |
31.5 |
2 |
19519332 (1), 8373992 (1) |
| sodium dodecylsulfate |
31.2 |
3 |
18272164 (1), 1718282 (1), 8670025 (1) |
| glutamine |
31 |
6 |
10576165 (2), 17313100 (1), 1525706 (1) |
| lysine |
25.5 |
1 |
10576165 (1) |
| citric acid |
20.9 |
1 |
7814752 (1) |
| calcium |
10.2 |
8 |
15769251 (2), 15153696 (1), 17080484 (1), 9745898 (1) (see all 6) |
| phenylalanine |
4.45 |
2 |
16620107 (1), 1663737 (1) |
| hydrogen |
0.565 |
4 |
18054952 (1), 1313424 (1), 9048421 (1) |
Search CenterWatch for drugs/clinical trials and news about STATH / STAT 
|
Transcripts for STATH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for STATH gene (2 alternative transcripts): NM_001009181.1 NM_003154.2 Unigene Cluster for STATH: Statherin Hs.654495 [show with all ESTs]Unigene Representative Sequence: CB9866517 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000246895(uc003heu.1 uc003hev.1) ENST00000507962 ENST00000510010 ENST00000381060 ENST00000507211 ENST00000511658 ENST00000506576
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STATH (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STATH (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): STATH (NM_001009181) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STATH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STATH  |
Additional cDNA sequence: AK311812.1 BC067219.1 M18078.1 M18371.1 24/28 DOTS entries (see all 28): DT.100676461 DT.100737085 DT.212626 DT.100685949 DT.100829015 DT.100829013 DT.92418592 DT.100829046 DT.100679868 DT.92420462 DT.100829038 DT.100829014 DT.121249385 DT.121249549 DT.100829034 DT.100680632 DT.100829011 DT.121249577 DT.121249581 DT.121249603 DT.444397 DT.121249572 DT.100829044 DT.121249270 24/1728 AceView cDNA sequences (see all 1728): BP334749 BP334433 BP334935 BP334069 AA376493 BP334484 BP333885 AA376694 BP334251 AA376496 BP334591 BP334762 BX486743 BP334178 BP333958 BX485098 BP334413 AA376638 BP334391 BP334166 BP335090 BX484850 BP334352 AA376574 GeneLoc Exon Structure
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Expression for STATH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STATH expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATTGGAGCTG
About this image See STATH Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for STATH
SOURCE GeneReport for Unigene cluster: Hs.654495 UniProtKB/Swiss-Prot: STAT_HUMAN, P02808Tissue specificity: Secreted by parotid and submandibular glands SABiosciences Custom PCR Arrays for STATH
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STATH Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STATH | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STATH | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STATH |
Orthologs for STATH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for STATH (if available) TreeFam Gene Tree for STATH (if available)  |
Paralogs for STATH gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for STATH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 4 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for STATH (70861647 - 70868287 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for STATH: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STATH |
|
Disorders
/ Diseases for STATH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STATH for disorders About GeneDecksing
OMIM gene information: 184470
OMIM disorders: --
12 diseases for STATH: About MalaCardsdental caries autism spectrum disorder actinomycosis periodontal disease periodontitis sjogren's syndrome rheumatoid arthritis hepatitis b narcolepsy gingivitis arthritis hepatitis 4 diseases from the University of Copenhagen DISEASES database for STATH:Actinomycosis Dental caries Denture stomatitis Atypical autism 1 Novoseek disease relationship for STATH gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| periodontal diseases |
8.26 |
1 |
17060618 (1) |
Human Genome Epidemiology (HuGE) Navigator: STATH (1 document) Export disorders for STATH gene to outside databases
|
Publications for STATH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STATH gene, integrated from 9 sources (see all 118): (articles sorted by number of sources associating them with STATH) | |  | Utopia: connect your pdf to the dynamic world of online information |
- cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva. (PubMed id 3502720)1, 2, 3 Sabatinai L.... Azen E. (1987)
- Structure and sequence determination of the gene encoding human salivary statherin. (PubMed id 2373369)1, 2, 9 Sabatini L.M.... Azen E.A. (1990)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence. (PubMed id 3426601)1, 2 Dickinson D.P.... Levine M.J. (1987)
- Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides. (PubMed id 3476566)1, 2 Oppenheim F.G.... Troxler R.F. (1987)
- Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva. (PubMed id 838735)1, 2 Schlesinger D.H. and Hay D.I. (1977)
- Statherin: a major boundary lubricant of human saliva. (PubMed id 1718282)1, 9 Douglas W.H....Levine M.J. (1991)
- Tyrosine sulfation of statherin. (PubMed id 17389930)2, 9 Kasinathan C....Ramasubbu N. (2007)
- Multiple forms of statherin in human salivary secretions. (PubMed id 1663737)2, 9 Jensen J.L....Oppenheim F.G. (1991)
- A statherin and calcium enriched layer at the air interface of human parotid saliva. (PubMed id 15769251)1, 9 Proctor G.B....Wilde P. (2005)
|
External Searches for STATH gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing STATH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STATH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STATH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for STATH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STATH gene: Search GeneIP for patents involving STATH
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for STATH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for STATH | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STATH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STATH | | OriGene Protein Over-expression Lysate for STATH | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for STATH | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STATH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STATH | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for STATH | | OriGene Custom Protein Services for STATH | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STATH | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STATH | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STATH | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STATH | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STATH | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STATH |
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 |  |  |  | |
| | | Search Tocris compounds for STATH |
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 | | STATH Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | Search ThermoFisher Antibodies for STATH |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STATH |
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