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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STATH Gene

protein-coding   GIFtS: 54
GCID: GC04P070861

Statherin

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
statherin1 2
STR2

External Ids:    HGNC: 113691   Entrez Gene: 67792   Ensembl: ENSG000001265497   OMIM: 1844705   UniProtKB: P028083   

Export aliases for STATH gene to outside databases

Previous GC identifers: GC04P070771 GC04P070910 GC04P071112 GC04P071177 GC04P071042 GC04P066659


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for STATH Gene: 
STATH (statherin) is a protein-coding gene. Diseases associated with STATH include actinomycosis, and denture stomatitis, and among its related super-pathways are Gastric acid secretion. GO annotations related to this gene include hydroxyapatite binding and structural constituent of tooth enamel.

UniProtKB/Swiss-Prot: STAT_HUMAN, P02808
Function: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the
precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface

Gene Wiki entry for STATH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STATH gene promoter:
         Nkx3-1 v2   CREB   Nkx3-1 v4   p53   deltaCREB   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTATH promoter sequence
   Search SABiosciences Chromatin IP Primers for STATH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STATH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

STATH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STATH gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P070861:  view genomic region     (about GC identifiers)

Start:
70,861,647 bp from pter      End:
70,868,287 bp from pter
Size:
6,641 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STAT_HUMAN, P02808 (See protein sequence)
Recommended Name: Statherin precursor  
Size: 62 amino acids; 7304 Da
Subcellular location: Secreted
Mass spectrometry: Mass=5380.0; Mass_error=0.3; Method=Electrospray; Range=20-62; Note=With phosphorylated Ser-21
and Ser-22; Source=PubMed:17313100;
Mass spectrometry: Mass=5363.0; Mass_error=0.3; Method=Electrospray; Range=20-62; Note=With phosphorylated Ser-21
and Ser-22 and transglutamine cross-link; Source=PubMed:17313100;
Secondary accessions: A6NKE9 B2R4F8
Alternative splicing: 2 isoforms:  P02808-1   P02808-2   

Explore the universe of human proteins at neXtProt for STATH: NX_P02808

Explore proteomics data for STATH at MOPED 

Post-translational modifications:

  • UniProtKB: Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5%
    is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva
  • UniProtKB: Sulfated on tyrosine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02808

  • STATH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STATH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001009181.1  NP_003145.1  

    ENSEMBL proteins: 
     ENSP00000246895   ENSP00000370448  

    Human Recombinant Protein Products for STATH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STATH
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for STATH
    GenScript Custom Purified and Recombinant Proteins Services for STATH
    Novus Biologicals STATH Lysate
    Sino Biological Recombinant Protein for STATH
    Sino Biological Cell Lysate for STATH 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STATH 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS1718282

    STATH for ontologies           About GeneDecksing



    STATH Antibody Products: 
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    GenScript Custom Superior Antibodies Services for STATH
    Novus Biologicals STATH Antibodies
    Abcam antibodies for STATH
    Cloud-Clone Corp. Antibodies for STATH 
    Search ThermoFisher Antibodies for STATH
    LSBio Antibodies in human, mouse, rat for STATH 

    Assay Products for STATH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STATH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STATH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STATH 
    Cloud-Clone Corp. CLIAs for STATH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005575 Statherin

    Graphical View of Domain Structure for InterPro Entry P02808

    ProtoNet protein and cluster: P02808

    UniProtKB/Swiss-Prot: STAT_HUMAN, P02808
    Similarity: Belongs to the histatin/statherin family


    STATH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT_HUMAN, P02808
    Function: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the
    precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface

         Genatlas biochemistry entry for STATH:
    statherin,salivary small acidic protein,calcium binding

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16203048
    GO:0030197extracellular matrix constituent, lubricant activity NAS1718282
    GO:0030345structural constituent of tooth enamel NAS1718282
    GO:0046848hydroxyapatite binding NAS1741693
         
    STATH for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for STATH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STATH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STATH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STATH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STATH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate STATH
    SwitchGear 3'UTR luciferase reporter plasmidSTATH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STATH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STATH

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of STATH

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STATH (NM_001009181)
    Sino Biological Human cDNA Clone for STATH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STATH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STATH
    Sirion Biotech Customized lentivirus for stable overexpression of STATH 
                         Customized lentivirus expression plasmids for stable overexpression of STATH 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for STATH
    Search LifeMap BioReagents cell lines for STATH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STATH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STATH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gastric acid secretion
    Salivary secretion0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for STATH):
        Salivary secretion


    STATH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STATH

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for STATH (P028081, 3 ENSP000002468954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX71, 3, ENSP000003020214EBI-738687,EBI-738582 I2D: score=1 STRING: ENSP00000302021
    PROL1Q999353, ENSP000003824854I2D: score=1 STRING: ENSP00000382485
    MUC5BQ9HC843, ENSP000004157934I2D: score=1 STRING: ENSP00000415793
    OVGP1Q128893, ENSP000003587474I2D: score=1 STRING: ENSP00000358747
    TP53ENSP000002693054STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification TAS1313424
    GO:0030502negative regulation of bone mineralization NAS1313424
    GO:0031214biomineral tissue development IEA--
    GO:0046541saliva secretion NAS1718282

    STATH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STATH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STATH (STAT)

    1 HMDB Compound for STATH    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/12 Novoseek inferred chemical compound relationships for STATH gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyapatite 80.3 94 16634639 (4), 18054952 (4), 1313424 (4), 19678690 (3) (see all 34)
    trifluoroethanol 36.3 2 1718282 (1), 9048421 (1)
    proline 31.5 2 19519332 (1), 8373992 (1)
    sodium dodecylsulfate 31.2 3 18272164 (1), 1718282 (1), 8670025 (1)
    glutamine 31 6 10576165 (2), 17313100 (1), 1525706 (1)
    lysine 25.5 1 10576165 (1)
    citric acid 20.9 1 7814752 (1)
    calcium 10.2 8 15769251 (2), 15153696 (1), 17080484 (1), 9745898 (1) (see all 6)
    phenylalanine 4.45 2 16620107 (1), 1663737 (1)
    hydrogen 0.565 4 18054952 (1), 1313424 (1), 9048421 (1)

    Search CenterWatch for drugs/clinical trials and news about STATH / STAT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STATH gene (2 alternative transcripts): 
    NM_001009181.1  NM_003154.2  

    Unigene Cluster for STATH:

    Statherin
    Hs.654495  [show with all ESTs]
    Unigene Representative Sequence: CB986651
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246895(uc003heu.1 uc003hev.1) ENST00000507962 ENST00000510010
    ENST00000381060 ENST00000507211 ENST00000511658 ENST00000506576

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STATH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate STATH
    SwitchGear 3'UTR luciferase reporter plasmidSTATH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STATH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STATH
    Clone
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    OriGene clones in human, mouse for STATH (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STATH (NM_001009181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STATH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STATH
    Sirion Biotech Customized lentivirus for stable overexpression of STATH 
                         Customized lentivirus expression plasmids for stable overexpression of STATH 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STATH
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STATH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STATH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STATH

    Additional mRNA sequence: 

    AK311812.1 BC067219.1 M18078.1 M18371.1 

    24/28 DOTS entries (see all 28):

    DT.100676461  DT.100737085  DT.212626  DT.100685949  DT.100829015  DT.100829013  DT.92418592  DT.100829046 
    DT.100679868  DT.92420462  DT.100829038  DT.100829014  DT.121249385  DT.121249549  DT.100829034  DT.100680632 
    DT.100829011  DT.121249577  DT.121249581  DT.121249603  DT.444397  DT.121249572  DT.100829044  DT.121249270 

    24/1728 AceView cDNA sequences (see all 1728):

    BX484850 AA376493 BP334479 BP334433 BP334749 AA376638 BP335009 BX485098 
    BP333771 BP334933 AA376709 BP334935 AA376574 BP334274 AA376694 NM_002159 
    AA376496 BP333885 AA376717 AA376710 AA376683 BP335034 BP333958 BX486743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STATH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGGAGCTG
    STATH Expression
    About this image


    See STATH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STATH

    SOURCE GeneReport for Unigene cluster: Hs.654495

    UniProtKB/Swiss-Prot: STAT_HUMAN, P02808
    Tissue specificity: Secreted by parotid and submandibular glands

        SABiosciences Custom PCR Arrays for STATH
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STATH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STATH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for STATH gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia STATH1 statherin 99.46(n)
    98.39(a)
      742648  XM_001161059.2  XP_001161059.1 


    ENSEMBL Gene Tree for STATH (if available)
    TreeFam Gene Tree for STATH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 SNPs in STATH are shown (see all 217)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399826381,2
    C--70859678(+) GTTGGA/GTAAAT 2 -- us2k10--------
    rs1448633011,2
    --70859920(+) CAGCAC/TGGGCA 2 -- us2k10--------
    rs762543441,2
    C,F--70859943(+) CAAGTC/TTCCAC 2 -- us2k13Minor allele frequency- T:0.19WA CSA 121
    rs1155259401,2
    C,F--70860036(+) CCACTT/CGAGCC 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1868462221,2
    --70860088(+) ACTCAA/CGACTG 2 -- us2k10--------
    rs1475122521,2
    --70860095(+) ACTGTA/GCTATG 2 -- us2k10--------
    rs793588971,2
    --70860115(+) CCCATC/TTCTGG 2 -- us2k10--------
    rs1443241091,2
    C--70860177(+) AAAGAG/TATTGT 2 -- us2k10--------
    rs1905394381,2
    --70860217(+) TATCTA/GTAATG 2 -- us2k10--------
    rs1836006531,2
    C--70860296(+) TTAAGA/TAATGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STATH (70861647 - 70868287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STATH:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5629n71CNV Loss21882294
    dgv5628n71CNV Loss21882294
    nsv879460CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STATH
    DNA2.0 Custom Variant and Variant Library Synthesis for STATH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 184470    OMIM disorders: --

    15 diseases for STATH:    About MalaCards
    actinomycosis    denture stomatitis    atypical autism    dental caries
    periodontal disease    narcolepsy    periodontitis    autism spectrum disorder
    stomatitis    sjogren's syndrome    gingivitis    hepatitis b
    rheumatoid arthritis    arthritis    hepatitis

    3 diseases from the University of Copenhagen DISEASES database for STATH:
    Atypical autism     Denture stomatitis     Dental caries

    STATH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for STATH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    periodontal diseases 8.26 1 17060618 (1)

    Human Genome Epidemiology (HuGE) Navigator: STATH (1 document)

    Export disorders for STATH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STATH gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with STATH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva. (PubMed id 3502720)1, 2, 3 Sabatinai L.... Azen E. (1987)
    2. Structure and sequence determination of the gene encoding human salivary statherin. (PubMed id 2373369)1, 2, 9 Sabatini L.M.... Azen E.A. (1990)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence. (PubMed id 3426601)1, 2 Dickinson D.P.... Levine M.J. (1987)
    5. Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides. (PubMed id 3476566)1, 2 Oppenheim F.G.... Troxler R.F. (1987)
    6. Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva. (PubMed id 838735)1, 2 Schlesinger D.H. and Hay D.I. (1977)
    7. Statherin: a major boundary lubricant of human saliva. (PubMed id 1718282)1, 9 Douglas W.H....Levine M.J. (1991)
    8. Tyrosine sulfation of statherin. (PubMed id 17389930)2, 9 Kasinathan C....Ramasubbu N. (2007)
    9. Multiple forms of statherin in human salivary secretions. (PubMed id 1663737)2, 9 Jensen J.L....Oppenheim F.G. (1991)
    10. A statherin and calcium enriched layer at the air interface of human parotid saliva. (PubMed id 15769251)1, 9 Proctor G.B....Wilde P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6779 HGNC: 11369 AceView: HTN3andHTN1andSTATH Ensembl:ENSG00000126549 euGenes: HUgn6779
    ECgene: STATH Kegg: 6779 H-InvDB: STATH

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for STATH Pharmacogenomics, SNPs, Pathways

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    Patent Information for STATH gene:
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