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Aliases for STATH Gene

Aliases for STATH Gene

  • Statherin 2 3
  • STR 3

External Ids for STATH Gene

Previous GeneCards Identifiers for STATH Gene

  • GC04P070771
  • GC04P070910
  • GC04P071112
  • GC04P071177
  • GC04P071042
  • GC04P066659
  • GC04P070861

Summaries for STATH Gene

GeneCards Summary for STATH Gene

STATH (Statherin) is a Protein Coding gene. Diseases associated with STATH include denture stomatitis and atypical autism. Among its related pathways are Salivary secretion. GO annotations related to this gene include structural constituent of tooth enamel and hydroxyapatite binding.

UniProtKB/Swiss-Prot for STATH Gene

  • Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface

Gene Wiki entry for STATH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STATH Gene

Genomics for STATH Gene

Regulatory Elements for STATH Gene

Genomic Location for STATH Gene

Start:
69,995,930 bp from pter
End:
70,002,570 bp from pter
Size:
6,641 bases
Orientation:
Plus strand

Genomic View for STATH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STATH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STATH Gene

Proteins for STATH Gene

  • Protein details for STATH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02808-STAT_HUMAN
    Recommended name:
    Statherin
    Protein Accession:
    P02808
    Secondary Accessions:
    • A6NKE9
    • B2R4F8

    Protein attributes for STATH Gene

    Size:
    62 amino acids
    Molecular mass:
    7304 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STATH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STATH Gene

Proteomics data for STATH Gene at MOPED

Post-translational modifications for STATH Gene

  • Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva
  • Sulfated on tyrosine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STATH Gene

No data available for DME Specific Peptides for STATH Gene

Domains for STATH Gene

Protein Domains for STATH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STATH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02808

UniProtKB/Swiss-Prot:

STAT_HUMAN :
  • P02808
Family:
  • Belongs to the histatin/statherin family.
genes like me logo Genes that share domains with STATH: view

No data available for Gene Families for STATH Gene

Function for STATH Gene

Molecular function for STATH Gene

GENATLAS Biochemistry:
statherin,salivary small acidic protein,calcium binding
UniProtKB/Swiss-Prot Function:
Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface

Gene Ontology (GO) - Molecular Function for STATH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16203048
GO:0030197 extracellular matrix constituent, lubricant activity NAS 1718282
GO:0030345 structural constituent of tooth enamel NAS 1718282
GO:0046848 hydroxyapatite binding NAS 1741693
genes like me logo Genes that share ontologies with STATH: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STATH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STATH Gene

Localization for STATH Gene

Subcellular locations from UniProtKB/Swiss-Prot for STATH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STATH Gene COMPARTMENTS Subcellular localization image for STATH gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for STATH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 1718282
genes like me logo Genes that share ontologies with STATH: view

Pathways for STATH Gene

SuperPathways for STATH Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with STATH: view

Pathways by source for STATH Gene

1 KEGG pathway for STATH Gene

Gene Ontology (GO) - Biological Process for STATH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification TAS 1313424
GO:0030502 negative regulation of bone mineralization NAS 1313424
GO:0031214 biomineral tissue development IEA --
GO:0046541 saliva secretion NAS 1718282
genes like me logo Genes that share ontologies with STATH: view

Compounds for STATH Gene

(1) HMDB Compounds for STATH Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(12) Novoseek inferred chemical compound relationships for STATH Gene

Compound -log(P) Hits PubMed IDs
hydroxyapatite 80.3 62
trifluoroethanol 36.3 2
proline 31.5 2
sodium dodecylsulfate 31.2 3
glutamine 31 4
genes like me logo Genes that share compounds with STATH: view

Transcripts for STATH Gene

Unigene Clusters for STATH Gene

Statherin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STATH

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STATH Gene

No ASD Table

Relevant External Links for STATH Gene

GeneLoc Exon Structure for
STATH
ECgene alternative splicing isoforms for
STATH

Expression for STATH Gene

mRNA expression in normal human tissues for STATH Gene

mRNA differential expression in normal tissues according to GTEx for STATH Gene

This gene is overexpressed in Minor Salivary Gland (51.4).

Protein differential expression in normal tissues for STATH Gene

This gene is overexpressed in Vitreous humor (66.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for STATH Gene

SOURCE GeneReport for Unigene cluster for STATH Gene Hs.654495

mRNA Expression by UniProt/SwissProt for STATH Gene

P02808-STAT_HUMAN
Tissue specificity: Secreted by parotid and submandibular glands
genes like me logo Genes that share expressions with STATH: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for STATH Gene

Orthologs for STATH Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for STATH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STATH 35
  • 99.46 (n)
  • 98.39 (a)
STATH 36
  • 98 (a)
OneToOne
Species with no ortholog for STATH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STATH Gene

ENSEMBL:
Gene Tree for STATH (if available)
TreeFam:
Gene Tree for STATH (if available)

Paralogs for STATH Gene

No data available for Paralogs for STATH Gene

Variants for STATH Gene

Sequence variations from dbSNP and Humsavar for STATH Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs776821 -- 69,995,141(+) TGATA(C/T)TCGTT upstream-variant-2KB
rs776822 -- 69,995,568(+) TACCA(C/T)GAGTT upstream-variant-2KB
rs776823 -- 69,995,704(+) CCAGC(A/G)TGCTT upstream-variant-2KB
rs776824 -- 69,996,257(+) TGGAG(A/G)CATAT intron-variant
rs776825 -- 69,998,122(+) CATCC(C/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STATH Gene

Variant ID Type Subtype PubMed ID
dgv5628n71 CNV Loss 21882294
dgv5629n71 CNV Loss 21882294
nsv879460 CNV Gain 21882294

Relevant External Links for STATH Gene

HapMap Linkage Disequilibrium report
STATH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STATH Gene

Disorders for STATH Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for STATH Gene in MalaCards »

(2) Diseases for STATH Gene including...

(3) University of Copenhagen DISEASES for STATH Gene

(1) Novoseek inferred disease relationships for STATH Gene

Disease -log(P) Hits PubMed IDs
periodontal diseases 8.26 1

Relevant External Links for STATH

Human Genome Epidemiology (HuGE) Navigator
STATH
genes like me logo Genes that share disorders with STATH: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for STATH Gene

Publications for STATH Gene

  1. Structure and sequence determination of the gene encoding human salivary statherin. (PMID: 2373369) Sabatini L.M. … Azen E.A. (Gene 1990) 3 4 23
  2. cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva. (PMID: 3502720) Sabatinai L. … Azen E. (Am. J. Hum. Genet. 1987) 2 3 4
  3. Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence. (PMID: 3426601) Dickinson D.P. … Levine M.J. (Biochem. Biophys. Res. Commun. 1987) 3 4
  4. Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides. (PMID: 3476566) Oppenheim F.G. … Troxler R.F. (J. Dent. Res. 1987) 3 4
  5. Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva. (PMID: 838735) Schlesinger D.H. … Hay D.I. (J. Biol. Chem. 1977) 3 4

Products for STATH Gene

Sources for STATH Gene

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