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STAT6 Gene

protein-coding   GIFtS: 73
GCID: GC12M057489

Signal Transducer And Activator Of Transcription 6, Interleukin-4...

  See STAT6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducer And Activator Of Transcription 6, Interleukin-4
Induced1 2
     STAT, Interleukin4-Induced2
D12S16442     Transcription Factor IL-4 STAT2
IL-4-STAT2     IL-4 Stat3
STAT6B2     EC 2.4.1.2278
STAT6C2     EC 2.7.7.68
Signal Transducer And Activator Of Transcription 62     

External Ids:    HGNC: 113681   Entrez Gene: 67782   Ensembl: ENSG000001668887   OMIM: 6015125   UniProtKB: P422263   

Export aliases for STAT6 gene to outside databases

Previous GC identifers: GC12M057464 GC12M057713 GC12M057205 GC12M055775 GC12M054527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAT6 Gene:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines
and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form
homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This
protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression
of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice
suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface
markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, May 2010)

GeneCards Summary for STAT6 Gene:
STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced) is a protein-coding gene. Diseases associated with STAT6 include solitary fibrous tumor, and urinary schistosomiasis. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT6_HUMAN, P42226
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in
IL4/interleukin-4- and IL3/interleukin-3-mediated signaling

Gene Wiki entry for STAT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAT6 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   NF-kappaB   STAT3   AP-2alpha isoform 4   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAT6 promoter sequence
   Search Chromatin IP Primers for STAT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

STAT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057489:  view genomic region     (about GC identifiers)

Start:
57,489,187 bp from pter      End:
57,525,922 bp from pter
Size:
36,736 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAT6_HUMAN, P42226 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 6  
Size: 847 amino acids; 94135 Da
Subunit: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via
its C-terminal LXXLL motif
1 PDB 3D structure from and Proteopedia for STAT6:
1OJ5 (3D)    
Secondary accessions: A8K316 B7ZA27 F5GXI9 Q5FBW5 Q71UP4
Alternative splicing: 3 isoforms:  P42226-1   P42226-2   P42226-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAT6: NX_P42226

Explore proteomics data for STAT6 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3 (By similarity).
    Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling1
  • Ubiquitination2 at Lys319, Lys647
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for STAT6 (P42226)
     GGSLGAQ  GRGYVPA 


    See STAT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171549.1  NP_001171550.1  NP_001171551.1  NP_001171552.1  NP_003144.3  

    ENSEMBL proteins: 
     ENSP00000300134   ENSP00000445409   ENSP00000438451   ENSP00000451742   ENSP00000444530  
     ENSP00000401486   ENSP00000451909   ENSP00000450428   ENSP00000450921   ENSP00000451546  
     ENSP00000452394   ENSP00000452373   ENSP00000451074   ENSP00000452203   ENSP00000450510  
     ENSP00000450665   ENSP00000451209   ENSP00000450747   ENSP00000450732  
    Reactome Protein details: P42226

    STAT6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAT6
    OriGene Protein Over-expression Lysate for STAT6
    OriGene MassSpec for STAT6
    OriGene Custom Protein Services for STAT6
    GenScript Custom Purified and Recombinant Proteins Services for STAT6
    Novus Biologicals STAT6 Proteins
    Novus Biologicals STAT6 Lysates
    Sino Biological Recombinant Protein for STAT6
    Sino Biological Cell Lysate for STAT6
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT6

     
    Search eBioscience for Proteins for STAT6 

    STAT6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT6
    R&D Systems Antibodies for STAT6
    Cell Signaling Technology (CST) Antibodies for STAT6 
    OriGene Antibodies for STAT6
    OriGene Custom Antibody Services for STAT6
    Novus Biologicals STAT6 Antibodies
    Abcam antibodies for STAT6
    Cloud-Clone Corp. Antibodies for STAT6
    ThermoFisher Antibodies for STAT6
    LSBio Antibodies in human, mouse, rat for STAT6

    STAT6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAT6
    R&D Systems ELISAs for STAT6         (see all)
    GenScript Custom Assay Services for STAT6
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT6
    Cloud-Clone Corp. CLIAs for STAT6
    Search eBioscience for ELISAs for STAT6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 10):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-dom_pair
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P42226

    ProtoNet protein and cluster: P42226

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT6_HUMAN, P42226
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with STAT6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT6_HUMAN, P42226
    Function: Carries out a dual function: signal transduction and activation of transcription. Involved in
    IL4/interleukin-4- and IL3/interleukin-3-mediated signaling

         Genatlas biochemistry entry for STAT6:
    signal transducer and activator of transcription 6,specifically activated by IL4 and IL13,overlapping
    D12S1644,with several alternatively spliced variants,expressed at higher levels in pancreatic beta cells

         Enzyme Numbers (IUBMB): EC 2.7.7.62 EC 2.4.1.2272

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with STAT6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for STAT6:
     Cell cycle / mitosis defect  Decreased nuclei size in G2M 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Stat6):
     cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
     reproductive system  respiratory system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with STAT6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for STAT6: Stat6tm1Gru Stat6tm1Aki Stat6tm1Jni

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAT6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT6

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ANTTCTTAAGAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT6:
    hsa-mir-26b-5p (MIRT028991), hsa-mir-335-5p (MIRT017016)

    Block miRNA regulation of human, mouse, rat STAT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAT6 (see all 18):
    hsa-miR-3673 hsa-let-7a-2* hsa-miR-144 hsa-miR-649 hsa-let-7g* hsa-miR-651 hsa-miR-18b* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSTAT6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAT6
    Predesigned siRNA for gene silencing in human, mouse, rat STAT6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT6

    Clone
    Products:
         
    OriGene clones in human, mouse for STAT6 (see all 23)
    OriGene ORF clones in mouse, rat for STAT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STAT6 (NM_003153)
    Sino Biological Human cDNA Clone for STAT6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT6
    Addgene plasmids for STAT6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT6
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAT6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT6

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13159) for STAT6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAT6_HUMAN, P42226: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with STAT6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAT6 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1CNTF Signaling
    CNTF Signaling0.50
    IL-3 Pathway0.46
    FLT3 Signaling0.50
    2Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    STING mediated induction of host immune responses0.00
    STAT6-mediated induction of chemokines0.00
    3IL-9 Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    4Signaling by FGFR
    Downstream signal transduction0.90
    Signaling by PDGF0.87
    5GPCR Pathway
    GPCR Pathway0.62
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with STAT6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for STAT6
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-4 Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STAT6 (see all 12)
        ErbB2-ErbB3 Heterodimers
    FLT3 Signaling
    MAPK Signaling
    IL-4 Pathway
    CNTF Signaling

    1 Cell Signaling Technology (CST) Pathway for STAT6
        Jak/Stat Pathway

    2 GeneGo (Thomson Reuters) Pathways for STAT6
        Immune response IL-4 signaling pathway
    Development PDGF signaling via STATs and NF-kB

    Selected BioSystems Pathways for STAT6 (see all 7)
        Adipogenesis
    IL-4 signaling Pathway
    IL-3 Signaling Pathway
    TSLP Signaling Pathway
    IL4-mediated signaling events


    2 Reactome Pathways for STAT6
        Downstream signal transduction
    STAT6-mediated induction of chemokines


    3 Kegg Pathways  (Kegg details for STAT6):
        Jak-STAT signaling pathway
    Hepatitis B
    Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT6 (see all 10): 
              Fibrosis in human mouse rat
              Notch Signaling Pathway in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAT6 (P422261, 2, 3 ENSP000003001344) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL4RP243941, 2, 3, ENSP000001706304EBI-1186478,EBI-367009 MINT-8035396 MINT-8038145 MINT-8037219 MINT-8038160 I2D: score=4 STRING: ENSP00000170630
    HIST2H3DQ71DI33, ENSP000003332774I2D: score=1 STRING: ENSP00000333277
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    EP300Q094721, 3, ENSP000002632534EBI-1186478,EBI-447295 I2D: score=3 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002296T-helper 1 cell lineage commitment IEA--
    GO:0002829negative regulation of type 2 immune response IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with STAT6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    5 ApexBio Compounds for STAT6     About this table
    CompoundAction CAS #
    FludarabineChemotherapy agent[21679-14-1]
    NSC 74859STAT3 inhibitor, binds to STAT3 SH2 domain, inhibits STAT3-DNA binding[501919-59-1]
    SD 1008JAK2/STAT3 signaling pathway inhibitor[960201-81-4]
    StatticSmall molecule inhibitor of STAT3[19983-44-9]
    WP1066Cell permeable STAT3 inhibitor[857064-38-1]

    Browse Tocris compounds for STAT6

    Selected Novoseek inferred chemical compound relationships for STAT6 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 63 87 12459556 (5), 9545332 (4), 10627454 (3), 7760829 (3) (see all 47)
    ifn-alpha 40.3 2 11991671 (1), 19707593 (1)
    pd 98,059 37.2 2 12801927 (1), 17264307 (1)
    mg 132 35.5 1 10654938 (1)
    sb 203580 26.8 1 17264307 (1)
    phosphatidylinositol 19.4 4 15684740 (1), 10452990 (1), 18716132 (1), 15733066 (1)
    cycloheximide 17.9 2 8703030 (1), 12459556 (1)
    4-hydroxytamoxifen 17.8 4 9686563 (1), 10626890 (1)
    cytidine 16.3 2 14978013 (1), 14767694 (1)
    wortmannin 12.1 1 9312117 (1)



    Find genes that share compounds with STAT6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAT6 gene (5 alternative transcripts): 
    NM_001178078.1  NM_001178079.1  NM_001178080.1  NM_001178081.1  NM_003153.4  

    Unigene Cluster for STAT6:

    Signal transducer and activator of transcription 6, interleukin-4 induced
    Hs.524518  [show with all ESTs]
    Unigene Representative Sequence: NM_001178078
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000300134(uc009zpe.3 uc001sna.3 uc009zpf.3 uc010srb.2 uc010src.2 uc010srd.2 uc009zpg.3)
    ENST00000555222 ENST00000538913 ENST00000557563 ENST00000543873 ENST00000556155
    ENST00000537215 ENST00000454075 ENST00000554764 ENST00000555318 ENST00000554202
    ENST00000555375 ENST00000553533 ENST00000557781 ENST00000555641 ENST00000555849
    ENST00000556259 ENST00000553499
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STAT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAT6 (see all 18):
    hsa-miR-3673 hsa-let-7a-2* hsa-miR-144 hsa-miR-649 hsa-let-7g* hsa-miR-651 hsa-miR-18b* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSTAT6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAT6
    Predesigned siRNA for gene silencing in human, mouse, rat STAT6
    Clone
    Products:
         
    OriGene clones in human, mouse for STAT6 (see all 23)
    OriGene ORF clones in mouse, rat for STAT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STAT6 (NM_003153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT6
    Addgene plasmids for STAT6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAT6
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT6
      QuantiTect SYBR Green Assays in human, mouse, rat STAT6
      QuantiFast Probe-based Assays in human, mouse, rat STAT6
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13159) for STAT6 

    Additional mRNA sequence: 

    AB103088.1 AB103089.1 AK290431.1 AK291044.1 AK298721.1 AK299094.1 AK308751.1 AK312471.1 
    AK316142.1 AK316236.1 BC004973.1 BC005823.2 BC075852.1 BT007380.1 NR_033659.1 U16031.1 

    Selected DOTS entries (see all 29):

    DT.97767371  DT.100797695  DT.448512  DT.433641  DT.95360334  DT.92405869  DT.97767424  DT.92010490 
    DT.100797683  DT.121175368  DT.92455115  DT.95337090  DT.121175338  DT.92455144  DT.121175323  DT.92455129 
    DT.95337051  DT.91825079  DT.92455137  DT.100728718  DT.40227500  DT.100033662  DT.91711641  DT.91765782 

    Selected AceView cDNA sequences (see all 444):

    BU728372 BQ896446 AI560607 BU177016 BM791381 CA390764 BF594093 BF063795 
    AW874307 BQ218833 CK430393 AA548159 AI311850 BM472885 CR603613 BE302269 
    AI026142 AI306736 BQ059735 CR606877 BC004973 AI344587 AI538610 AI092443 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAT6 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                          -     -     -     -     -                                                     -                 -     -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -                 -     -     -                       -                                                   
    SP5:                                                                                                        -                                                   

    ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:        -     -                       -                             -     -                                             
    SP2:        -     -                                                                                                         
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for STAT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCCTCCA
    STAT6 Expression
    About this image


    STAT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    STAT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524518
        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT6 (see all 10): 
              Fibrosis in human mouse rat
              Notch Signaling Pathway in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STAT6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat61 , 5 signal transducer and activator of transcription 61, 5 85.46(n)1
    86.02(a)1
      10 (74.59 cM)5
    208521  NM_009284.21  NP_033310.21 
     1276429865 
    chicken
    (Gallus gallus)
    Aves STAT66
    signal transducer and activator of transcription 6...
    83(a)
    1 ↔ 1
    AADN03024934.1(21-1263)
    lizard
    (Anolis carolinensis)
    Reptilia STAT66
    signal transducer and activator of transcription 6...
    59(a)
    1 ↔ 1
    GL343212.1(2609909-2645790)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stat61 signal transducer and activator of transcription 6, interleukin-4 induced less 58.02(n)
    53.14(a)
      100485184  XM_002939709.2  XP_002939755.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stat61 signal transducer and activator of transcription 6, interleukin-4 induced less 51.72(n)
    41.78(a)
      337413  NM_001130590.1  NP_001124062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stat92E3 signal transduction transcription
    factor
    35(a)   3 92F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H4A.173   -- 29(a)   IV(16664481-16671418)   --


    ENSEMBL Gene Tree for STAT6 (if available)
    TreeFam Gene Tree for STAT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAT6 gene
    STAT5B2  STAT12  STAT42  STAT22  STAT32  STAT5A2  
    6 SIMAP similar genes for STAT6 using alignment to 13 protein entries:     STAT6_HUMAN (see all proteins):
    STAT6B    STAT3    STAT4    STAT5A    STAT5B    STAT2

    Find genes that share paralogs with STAT6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAT6 (see all 581)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30249851,2
    C,F,H--57322499(-) ACCACG/ACACCC 6 -- ds50016Minor allele frequency- A:0.03NS NA 328
    rs1495211261,2
    C--57322551(+) TCCAGA/GGCATC 6 -- ds50010--------
    rs1141831101,2
    C,F--57322572(+) CCCTCC/TCTCAC 6 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1831704171,2
    C--57322573(+) CCTCCC/TTCACA 6 -- ds50010--------
    rs30249841,2
    C,H--57322584(-) GGAGTG/CTGTTG 6 -- ds50017Minor allele frequency- C:0.01NS EA NA 380
    rs1873525651,2
    --57322655(+) AAGGGA/GGACTT 6 -- ds50010--------
    rs1922066811,2
    C--57322705(+) CAGAAC/TTGGGG 6 -- ds50010--------
    rs798296051,2
    C,F--57322740(+) TTCTCC/TCCTCT 6 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1439505371,2
    --57322753(+) TTCCCC/TGTTTT 6 -- ds50010--------
    rs1831763111,2
    --57322837(+) AAGTCA/CTTTGC 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for STAT6 (57489187 - 57525922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STAT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832428CNV Gain17160897

    Human Gene Mutation Database (HGMD): STAT6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT6
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601512    OMIM disorders: --

    5 diseases for STAT6:    
    About MalaCards
    solitary fibrous tumor    urinary schistosomiasis    brain glioma    primary mediastinal large b-cell lymphoma
    schistosomiasis

    4 diseases from the University of Copenhagen DISEASES database for STAT6:
    Asthma     Eosinophilia     Hypersensitivity reaction type I disease     Atopic dermatitis

    Find genes that share disorders with STAT6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for STAT6 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 61.9 8 11295643 (2), 19247692 (1), 15235025 (1), 12759487 (1) (see all 6)
    asthma 59.7 32 15637551 (3), 19175798 (2), 11692112 (2), 9768594 (2) (see all 19)
    atopy 51.7 5 11678849 (1), 15105161 (1), 11069563 (1), 11912010 (1)
    severe combined immunodeficiency, x-linked 45.4 2 8557662 (1)
    inflammation 45.3 11 15297269 (1), 19175798 (1), 18691065 (1), 19494273 (1) (see all 10)
    allergy 40 6 15080810 (2), 18154619 (1), 15536416 (1), 10353570 (1) (see all 5)
    airways disease 36.3 2 11839568 (2)
    dermatitis atopic 33.7 2 11912010 (1), 12759487 (1)
    lymphoma b-cell 32.6 5 19423726 (2), 18401415 (1), 17210636 (1), 15044251 (1)
    hodgkin disease 28 3 17652621 (1), 19440213 (1), 15044251 (1)

    Genetic Association Database (GAD): STAT6
    Human Genome Epidemiology (HuGE) Navigator: STAT6 (50 documents)

    Export disorders for STAT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAT6 gene, integrated from 10 sources (see all 556):
    (articles sorted by number of sources associating them with STAT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An interleukin-4-induced transcription factor: IL-4 Stat. (PubMed id 8085155)1, 2, 3 Hou J.... McKnight S.L. (Science 1994)
    2. Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. (PubMed id 17362266)1, 4, 9 Yabiku K....Takasu N. (Clin. Exp. Immunol. 2007)
    3. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. (PubMed id 12759487)1, 4, 9 Tamura K....Morikawa A. (Int. Arch. Allergy Immunol. 2003)
    4. Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. (PubMed id 19282076)1, 4, 9 Sperati C.J....Kao W.H. (Am. J. Kidney Dis. 2009)
    5. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. (PubMed id 17210636)1, 2, 9 Lu X....Lossos I.S. (Mol. Cell. Biol. 2007)
    6. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PubMed id 14757047)1, 2, 9 Razeto A....Becker S. (J. Mol. Biol. 2004)
    7. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. (PubMed id 12138096)1, 2, 9 Litterst C.M. and Pfitzner E. (J. Biol. Chem. 2002)
    8. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. (PubMed id 15637551)1, 4, 9 PykAolAoinen M....Lahesmaa R. (J. Allergy Clin. Immunol. 2005)
    9. Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. (PubMed id 15342695)1, 4, 9 Weidinger S....Illig T. (J. Med. Genet. 2004)
    10. The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. (PubMed id 15888279)1, 4, 9 Klein W....Griga T. (Dig Liver Dis 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6778 HGNC: 11368 AceView: STAT6 Ensembl:ENSG00000166888 euGenes: HUgn6778
    ECgene: STAT6 Kegg: 6778 H-InvDB: STAT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STAT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT6 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/stat6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAT6 gene:
    Search GeneIP for patents involving STAT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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