Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAT6 Gene

protein-coding   GIFtS: 71
GCID: GC12M057489

Signal Transducer And Activator Of Transcription 6, Interleukin-4...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 6, Interleukin-4
Induced1 2
     STAT, Interleukin4-Induced2
D12S16442     Transcription Factor IL-4 STAT2
IL-4-STAT2     IL-4 Stat3
STAT6B2     EC 2.4.1.2278
STAT6C2     EC 2.7.7.68
Signal Transducer And Activator Of Transcription 62     

External Ids:    HGNC: 113681   Entrez Gene: 67782   Ensembl: ENSG000001668887   OMIM: 6015125   UniProtKB: P422263   

Export aliases for STAT6 gene to outside databases

Previous GC identifers: GC12M057464 GC12M057713 GC12M057205 GC12M055775 GC12M054527


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT6 Gene:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines
and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form
homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This
protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression
of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice
suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface
markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, May 2010)

GeneCards Summary for STAT6 Gene: 
STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced) is a protein-coding gene. Diseases associated with STAT6 include solitary fibrous tumor, and urinary schistosomiasis, and among its related super-pathways are CNTF Signaling and IL-9 Signaling Pathways. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT6_HUMAN, P42226
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in
interleukin-4 signalling

Gene Wiki entry for STAT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAT6 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   NF-kappaB   STAT3   AP-2alpha isoform 4   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for STAT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

STAT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057489:  view genomic region     (about GC identifiers)

Start:
57,489,187 bp from pter      End:
57,525,922 bp from pter
Size:
36,736 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STAT6_HUMAN, P42226 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 6  
Size: 847 amino acids; 94135 Da
Subunit: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via
its C-terminal LXXLL motif
Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
1 PDB 3D structure from and Proteopedia for STAT6:
1OJ5 (3D)    
Secondary accessions: A8K316 B7ZA27 F5GXI9 Q5FBW5 Q71UP4
Alternative splicing: 3 isoforms:  P42226-1   P42226-2   P42226-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAT6: NX_P42226

Explore proteomics data for STAT6 at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine phosphorylated following stimulation by IL-4 and IL-3 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42226

  • 2 DME Specific Peptides for STAT6 (P42226)
     GGSLGAQ  GRGYVPA 

    STAT6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STAT6 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001171549.1  NP_001171550.1  NP_001171551.1  NP_001171552.1  NP_003144.3  

    ENSEMBL proteins: 
     ENSP00000300134   ENSP00000445409   ENSP00000438451   ENSP00000451742   ENSP00000444530  
     ENSP00000401486   ENSP00000451909   ENSP00000450428   ENSP00000450921   ENSP00000451546  
     ENSP00000452394   ENSP00000452373   ENSP00000451074   ENSP00000452203   ENSP00000450510  
     ENSP00000450665   ENSP00000451209   ENSP00000450747   ENSP00000450732  
    Reactome Protein details: P42226
    Human Recombinant Protein Products for STAT6: 
    EMD Millipore Purified and/or Recombinant STAT6 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAT6
    OriGene Protein Over-expression Lysate for STAT6
    OriGene MassSpec for STAT6 
    OriGene Custom Protein Services for STAT6
    GenScript Custom Purified and Recombinant Proteins Services for STAT6
    Novus Biologicals STAT6 Proteins
    Novus Biologicals STAT6 Lysates
    Sino Biological Recombinant Protein for STAT6
    Sino Biological Cell Lysate for STAT6 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT6 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    STAT6 for ontologies           About GeneDecksing



    STAT6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT6
    R&D Systems Antibodies for STAT6
    Cell Signaling Technology (CST) Antibodies for STAT6 
    OriGene Antibodies for STAT6
    OriGene Custom Antibody Services for STAT6
    GenScript Custom Superior Antibodies Services for STAT6
    Novus Biologicals STAT6 Antibodies
    Abcam antibodies for STAT6
    Cloud-Clone Corp. Antibodies for STAT6 
    ThermoFisher Antibodies for STAT6
    LSBio Antibodies in human, mouse, rat for STAT6 

    Assay Products for STAT6: 
    EMD Millipore Kits and Assays for the Analysis of STAT6
    OriGene Custom Assay Services for STAT6
    R&D Systems ELISAs for STAT6         (see all)
    GenScript Custom Assay Services for STAT6
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT6 
    Cloud-Clone Corp. CLIAs for STAT6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    5/9 InterPro protein domains (see all 9):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-like_dom
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P42226

    ProtoNet protein and cluster: P42226

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT6_HUMAN, P42226
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    STAT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT6_HUMAN, P42226
    Function: Carries out a dual function: signal transduction and activation of transcription. Involved in
    interleukin-4 signalling

         Genatlas biochemistry entry for STAT6:
    signal transducer and activator of transcription 6,specifically activated by IL4 and IL13,overlapping
    D12S1644,with several alternatively spliced variants,expressed at higher levels in pancreatic beta cells

         Enzyme Numbers (IUBMB): EC 2.7.7.62 EC 2.4.1.2272

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
         
    STAT6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for STAT6:
     Cell cycle / mitosis defect  Decreased nuclei size in G2M 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Stat6):
     cellular  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
     reproductive system  respiratory system  tumorigenesis  vision/eye 

    STAT6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STAT6: Stat6tm1Gru Stat6tm1Aki Stat6tm1Jni

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STAT6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT6 

    10/87 SABiosciences Target genes for STAT6 (see all 87):
    ACCSL ALG1 ASRGL1 ATG16L1 AZFP C14orf2 CCDC63 CLDN8 CNOT2 CTAGE1

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT6
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT6 (see all 18):
    hsa-miR-3673 hsa-let-7a-2* hsa-miR-144 hsa-miR-649 hsa-let-7g* hsa-miR-651 hsa-miR-18b* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSTAT6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STAT6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT6
    Sirion Biotech Customized adenovirus for overexpression of STAT6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STAT6 (see all 19)
    OriGene ORF clones in mouse, rat for STAT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STAT6 (NM_003153)
    Sino Biological Human cDNA Clone for STAT6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT6
    Sirion Biotech Customized lentivirus for stable overexpression of STAT6 
                         Customized lentivirus expression plasmids for stable overexpression of STAT6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT6
    Search LifeMap BioReagents cell lines for STAT6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STAT6 About   (see all 28)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CNTF Signaling
    CNTF Signaling0.50
    IL-3 Pathway0.46
    FLT3 Signaling0.50
    2Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    3Signaling by FGFR
    Downstream signal transduction0.90
    Signaling by PDGF0.85
    4GPCR Pathway
    GPCR Pathway0.62
    Pancreatic Adenocarcinoma0.59
    5IRF3-mediated induction of type I IFN
    STAT6-mediated induction of chemokines0.50
    STING mediated induction of host immune responses0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for STAT6
        Development PDGF signaling via STATs and NF-kB
    Immune response IL-4 signaling pathway

    3 R&D Systems Pathways for STAT6
        IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-4 Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT6 (see all 12)
        ErbB2-ErbB3 Heterodimers
    FLT3 Signaling
    MAPK Signaling
    IL-4 Pathway
    CNTF Signaling

    1 Cell Signaling Technology (CST) Pathway for STAT6
        Jak/Stat Pathway

    2 GeneGo (Thomson Reuters) Pathways for STAT6
        Immune response IL-4 signaling pathway
    Development PDGF signaling via STATs and NF-kB

    5/7 BioSystems Pathways for STAT6 (see all 7)
        Adipogenesis
    IL-4 signaling Pathway
    IL-3 Signaling Pathway
    TSLP Signaling Pathway
    IL12-mediated signaling events


    5/8        Reactome Pathways for STAT6 (see all 8)
        Cytosolic sensors of pathogen-associated DNA
    Downstream signal transduction
    Signal Transduction
    STING mediated induction of host immune responses
    Signaling by PDGF


    3         Kegg Pathways  (Kegg details for STAT6):
        Jak-STAT signaling pathway
    Hepatitis B
    Inflammatory bowel disease (IBD)


    STAT6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for STAT6 (P422261, 2, 3 ENSP000003001344) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL4RP243942, 3, ENSP000001706304MINT-8035396 MINT-8038145 MINT-8037219 MINT-8038160 I2D: score=4 STRING: ENSP00000170630
    HIST2H3DQ71DI33, ENSP000003332774I2D: score=1 STRING: ENSP00000333277
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    CREBBPQ927933, ENSP000002623674I2D: score=4 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002296T-helper 1 cell lineage commitment IEA--
    GO:0002829negative regulation of type 2 immune response IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    STAT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STAT6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STAT6

    10/28 Novoseek inferred chemical compound relationships for STAT6 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 63 87 12459556 (5), 9545332 (4), 10627454 (3), 7760829 (3) (see all 47)
    ifn-alpha 40.3 2 11991671 (1), 19707593 (1)
    pd 98,059 37.2 2 12801927 (1), 17264307 (1)
    mg 132 35.5 1 10654938 (1)
    sb 203580 26.8 1 17264307 (1)
    phosphatidylinositol 19.4 4 15684740 (1), 10452990 (1), 18716132 (1), 15733066 (1)
    cycloheximide 17.9 2 8703030 (1), 12459556 (1)
    4-hydroxytamoxifen 17.8 4 9686563 (1), 10626890 (1)
    cytidine 16.3 2 14978013 (1), 14767694 (1)
    wortmannin 12.1 1 9312117 (1)

    Search CenterWatch for drugs/clinical trials and news about STAT6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STAT6 gene (5 alternative transcripts): 
    NM_001178078.1  NM_001178079.1  NM_001178080.1  NM_001178081.1  NM_003153.4  

    Unigene Cluster for STAT6:

    Signal transducer and activator of transcription 6, interleukin-4 induced
    Hs.524518  [show with all ESTs]
    Unigene Representative Sequence: NM_001178078
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000300134(uc009zpe.3 uc001sna.3 uc009zpf.3 uc010srb.2 uc010src.2 uc010srd.2 uc009zpg.3)
    ENST00000555222 ENST00000538913 ENST00000557563 ENST00000543873 ENST00000556155
    ENST00000537215 ENST00000454075 ENST00000554764 ENST00000555318 ENST00000554202
    ENST00000555375 ENST00000553533 ENST00000557781 ENST00000555641 ENST00000555849
    ENST00000556259 ENST00000553499
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT6
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT6 (see all 18):
    hsa-miR-3673 hsa-let-7a-2* hsa-miR-144 hsa-miR-649 hsa-let-7g* hsa-miR-651 hsa-miR-18b* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidSTAT6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STAT6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT6
    Clone
    Products:
         
    OriGene clones in human, mouse for STAT6 (see all 19)
    OriGene ORF clones in mouse, rat for STAT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): STAT6 (NM_003153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT6
    Sirion Biotech Customized lentivirus for stable overexpression of STAT6 
                         Customized lentivirus expression plasmids for stable overexpression of STAT6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAT6
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAT6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT6

    Additional mRNA sequence: 

    AB103088.1 AB103089.1 AK290431.1 AK291044.1 AK298721.1 AK299094.1 AK308751.1 AK312471.1 
    AK316142.1 AK316236.1 BC004973.1 BC005823.2 BC075852.1 BT007380.1 NR_033659.1 U16031.1 

    24/29 DOTS entries (see all 29):

    DT.97767371  DT.100797695  DT.448512  DT.433641  DT.95360334  DT.92405869  DT.97767424  DT.92010490 
    DT.100797683  DT.121175368  DT.92455115  DT.95337090  DT.121175338  DT.92455144  DT.121175323  DT.92455129 
    DT.95337051  DT.91825079  DT.92455137  DT.100728718  DT.40227500  DT.100033662  DT.91711641  DT.91765782 

    24/444 AceView cDNA sequences (see all 444):

    BC075852 AA836835 AI829821 BM991084 AI092443 BU728372 AI678739 AI660041 
    CR606877 BF063795 BQ059735 BX349303 BM993461 BM921687 AI817516 AI888031 
    BM791381 AA465315 BF594093 AI344587 BE298694 BU543479 AI811628 U16031 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for STAT6 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                          -     -     -     -     -                                                     -                 -     -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -                 -     -     -                       -                                                   
    SP5:                                                                                                        -                                                   

    ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:        -     -                       -                             -     -                                             
    SP2:        -     -                                                                                                         
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for STAT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAT6 expression in normal human tissues (normalized intensities)      STAT6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCCTCCA
    STAT6 Expression
    About this image


    STAT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             cervix, uterine ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See STAT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAT6

    SOURCE GeneReport for Unigene cluster: Hs.524518
        SABiosciences Expression via Pathway-Focused PCR Arrays including STAT6 (see all 10): 
              Fibrosis in human mouse rat
              Notch Signaling Pathway in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STAT6
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAT6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STAT6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat61 , 5 signal transducer and activator of transcription 61, 5 85.78(n)1
    86.62(a)1
      10 (74.59 cM)5
    208521  NM_009284.21  NP_033310.21 
     1276429865 
    chicken
    (Gallus gallus)
    Aves LOC1008591961 signal transducer and transcription activator 6-like less 78.81(n)
    83(a)
      100859196  XM_003643566.1  XP_003643614.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAT66
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343212.1(2609909-2645790)
    zebrafish
    (Danio rerio)
    Actinopterygii stat61 signal transducer and activator of transcription 6, interleukin-4 induced less 51.56(n)
    41.36(a)
      337413  NM_001130590.1  NP_001124062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stat92E3 signal transduction transcription
    factor
    35(a)   3 92F1   --


    ENSEMBL Gene Tree for STAT6 (if available)
    TreeFam Gene Tree for STAT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAT6 gene
    STAT5B2  STAT12  STAT42  STAT22  STAT32  STAT5A2  
    5 SIMAP similar genes for STAT6 using alignment to 13 protein entries:     STAT6_HUMAN (see all proteins):
    STAT6B    STAT3    STAT4    STAT5A    STAT5B

    STAT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/581 SNPs in STAT6 are shown (see all 581)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30249851,2
    C,F,H--57322499(-) ACCACG/ACACCC 6 -- ds50016Minor allele frequency- A:0.03NS NA 328
    rs1495211261,2
    C--57322551(+) TCCAGA/GGCATC 6 -- ds50010--------
    rs1141831101,2
    C,F--57322572(+) CCCTCC/TCTCAC 6 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1831704171,2
    C--57322573(+) CCTCCC/TTCACA 6 -- ds50010--------
    rs30249841,2
    C,H--57322584(-) GGAGTG/CTGTTG 6 -- ds50017Minor allele frequency- C:0.01NS EA NA 380
    rs1873525651,2
    --57322655(+) AAGGGA/GGACTT 6 -- ds50010--------
    rs1922066811,2
    C--57322705(+) CAGAAC/TTGGGG 6 -- ds50010--------
    rs798296051,2
    C,F--57322740(+) TTCTCC/TCCTCT 6 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1439505371,2
    --57322753(+) TTCCCC/TGTTTT 6 -- ds50010--------
    rs1831763111,2
    --57322837(+) AAGTCA/CTTTGC 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for STAT6 (57489187 - 57525922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STAT6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832428CNV Gain17160897


    Human Gene Mutation Database (HGMD): STAT6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT6
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601512    OMIM disorders: --

    20/63 diseases for STAT6 (see all 63):    About MalaCards
    solitary fibrous tumor    urinary schistosomiasis    primary mediastinal large b-cell lymphoma    brain glioma
    schistosomiasis    eosinophilic esophagitis    mediastinitis    food allergy
    severe combined immunodeficiency    atopy    ischemic heart disease    graves' disease
    allergic rhinitis    eosinophilia    allergic asthma    gigantism
    rhinitis    eczema    hematopoietic stem cell transplantation    glioblastoma

    4 diseases from the University of Copenhagen DISEASES database for STAT6:
    Asthma     Eosinophilia     Hypersensitivity reaction type I disease     Atopic dermatitis

    STAT6 for disorders           About GeneDecksing

    10/41 Novoseek inferred disease relationships for STAT6 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 61.9 8 11295643 (2), 19247692 (1), 15235025 (1), 12759487 (1) (see all 6)
    asthma 59.7 32 15637551 (3), 19175798 (2), 11692112 (2), 9768594 (2) (see all 19)
    atopy 51.7 5 11678849 (1), 15105161 (1), 11069563 (1), 11912010 (1)
    severe combined immunodeficiency, x-linked 45.4 2 8557662 (1)
    inflammation 45.3 11 15297269 (1), 19175798 (1), 18691065 (1), 19494273 (1) (see all 10)
    allergy 40 6 15080810 (2), 18154619 (1), 15536416 (1), 10353570 (1) (see all 5)
    airways disease 36.3 2 11839568 (2)
    dermatitis atopic 33.7 2 11912010 (1), 12759487 (1)
    lymphoma b-cell 32.6 5 19423726 (2), 18401415 (1), 17210636 (1), 15044251 (1)
    hodgkin disease 28 3 17652621 (1), 19440213 (1), 15044251 (1)

    Genetic Association Database (GAD): STAT6
    Human Genome Epidemiology (HuGE) Navigator: STAT6 (50 documents)

    Export disorders for STAT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAT6 gene, integrated from 9 sources (see all 547):
    (articles sorted by number of sources associating them with STAT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An interleukin-4-induced transcription factor: IL-4 Stat. (PubMed id 8085155)1, 2, 3 Hou J....McKnight S.L. (1994)
    2. Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. (PubMed id 17362266)1, 4, 9 Yabiku K....Takasu N. (2007)
    3. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. (PubMed id 12759487)1, 4, 9 Tamura K....Morikawa A. (2003)
    4. Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. (PubMed id 19282076)1, 4, 9 Sperati C.J....Kao W.H. (2009)
    5. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PubMed id 14757047)1, 2, 9 Razeto A....Becker S. (2004)
    6. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. (PubMed id 12138096)1, 2, 9 Litterst C.M. and Pfitzner E. (2002)
    7. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. (PubMed id 15637551)1, 4, 9 Pykalainen M....Lahesmaa R. (2005)
    8. Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. (PubMed id 15342695)1, 4, 9 Weidinger S....Illig T. (2004)
    9. The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. (PubMed id 15888279)1, 4, 9 Klein W....Griga T. (2005)
    10. Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome. (PubMed id 19011907)1, 4, 9 Ikeuchi Y....Morikawa A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6778 HGNC: 11368 AceView: STAT6 Ensembl:ENSG00000166888 euGenes: HUgn6778
    ECgene: STAT6 Kegg: 6778 H-InvDB: STAT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT6 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/stat6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STAT6 gene:
    Search GeneIP for patents involving STAT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT6
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of STAT6
     EMD Millipore Purified and/or Recombinant STAT6 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for STAT6 (STAT6)   Browse Cell Culture Products  
     ELISAs for STAT6 (STAT6)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for STAT6 (STAT6)  
     OriGene Antibodies for STAT6   OriGene RNAi products in human, mouse, rat for STAT6  
     OriGene qPCR primer pairs and template standards for STAT6   OriGene Protein Over-expression Lysate for STAT6  
     OriGene MassSpec something-or-other for STAT6   OriGene clones in human, mouse for STAT6  
     OriGene qSTAR qPCR primer pairs in human, mouse for STAT6   OriGene Purified Protein for STAT6  
     OriGene ORF clones in mouse, rat for STAT6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STAT6   OriGene Custom Protein Services for STAT6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAT6
     QIAGEN SeqTarget long-range PCR primers for resequencing STAT6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT6
     GenScript Custom Purified and Recombinant Proteins Services for STAT6 GenScript cDNA clones with any tag delivered in your preferred vector for STAT6
     GenScript Custom Assay Services for STAT6 GenScript Custom Superior Antibodies Services for STAT6
     GenScript Custom overexpressing Cell Line Services for STAT6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for STAT6 

     Regulatory tfbs in STAT6 promoter
     Search Chromatin IP Primers for STAT6
     RT2 qPCR Primer Assay in human, mouse, rat STAT6
     GNC Network for STAT6
     SABiosciences PCR Arrays including human, mouse, rat STAT6
     Search Tocris compounds for STAT6
     Proteins and Antibodies for STAT6
     Cell Lysates for STAT6
     cDNA Clones for STAT6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STAT6 antibodies
     STAT6 proteins
     STAT6 lysates
     Antibodies for STAT6
     See all of Abcam's Antibodies, Kits and Proteins for STAT6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STAT6
     Antibodies for STAT6
     ELISAs for STAT6
     CLIAs for STAT6
     Search LifeMap BioReagents cell lines for STAT6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT6
     SwitchGear 3'UTR luciferase reporter plasmids for STAT6
     SwitchGear Promoter luciferase reporter plasmids for STAT6
     ThermoFisher Antibodies for STAT6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STAT6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAT6
    Customized:
     lentivirus for stable overexpression of STAT6
     lentivirus expression plasmids for stable overexpression of STAT6
     adenovirus for overexpression of STAT6
     LSBio Antibodies in human, mouse, rat for STAT6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STAT6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4