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Aliases for STAT6 Gene

Aliases for STAT6 Gene

  • Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced 2 3
  • Signal Transducer And Activator Of Transcription 6 3
  • Transcription Factor IL-4 STAT 3
  • STAT, Interleukin4-Induced 3
  • EC 2.4.1.227 63
  • EC 2.7.7.6 63
  • IL-4-STAT 3
  • IL-4 Stat 4
  • D12S1644 3
  • STAT6B 3
  • STAT6C 3

External Ids for STAT6 Gene

Previous GeneCards Identifiers for STAT6 Gene

  • GC12M057464
  • GC12M057713
  • GC12M057205
  • GC12M055775
  • GC12M054527
  • GC12M057489

Summaries for STAT6 Gene

Entrez Gene Summary for STAT6 Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for STAT6 Gene

STAT6 (Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced) is a Protein Coding gene. Diseases associated with STAT6 include hemangiopericytoma and urinary schistosomiasis. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot for STAT6 Gene

  • Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Gene Wiki entry for STAT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT6 Gene

Genomics for STAT6 Gene

Genomic Location for STAT6 Gene

Start:
57,095,404 bp from pter
End:
57,132,139 bp from pter
Size:
36,736 bases
Orientation:
Minus strand

Genomic View for STAT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT6 Gene

Proteins for STAT6 Gene

  • Protein details for STAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42226-STAT6_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 6
    Protein Accession:
    P42226
    Secondary Accessions:
    • A8K316
    • B7ZA27
    • F5GXI9
    • Q5FBW5
    • Q71UP4

    Protein attributes for STAT6 Gene

    Size:
    847 amino acids
    Molecular mass:
    94135 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.

    Three dimensional structures from OCA and Proteopedia for STAT6 Gene

    Alternative splice isoforms for STAT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT6 Gene

Proteomics data for STAT6 Gene at MOPED

Selected DME Specific Peptides for STAT6 Gene

Post-translational modifications for STAT6 Gene

  • Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.
  • Ubiquitination at Lys319 and Lys647
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STAT6 (STAT6)

Domains for STAT6 Gene

Gene Families for STAT6 Gene

HGNC:
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for STAT6 Gene

Graphical View of Domain Structure for InterPro Entry

P42226

UniProtKB/Swiss-Prot:

STAT6_HUMAN :
  • P42226
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT6: view

Function for STAT6 Gene

Molecular function for STAT6 Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription 6,specifically activated by IL4 and IL13,overlapping D12S1644,with several alternatively spliced variants,expressed at higher levels in pancreatic beta cells
UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Enzyme Numbers (IUBMB) for STAT6 Gene

Gene Ontology (GO) - Molecular Function for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding --
genes like me logo Genes that share ontologies with STAT6: view
genes like me logo Genes that share phenotypes with STAT6: view

Animal Models for STAT6 Gene

MGI Knock Outs for STAT6:

Animal Model Products

miRNA for STAT6 Gene

miRTarBase miRNAs that target STAT6
Targeting motifs for STAT6 Gene
HOMER Transcription Factor Regulatory Elements motif STAT6
  • Consensus sequence: ANTTCTTAAGAA Submotif: canonical Cell Type: CD4 GeoId: GSE22104

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT6

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting for STAT6 Gene

Localization for STAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT6 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT6 Gene COMPARTMENTS Subcellular localization image for STAT6 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAT6: view

Pathways for STAT6 Gene

genes like me logo Genes that share pathways with STAT6: view

PCR Array Products

Gene Ontology (GO) - Biological Process for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002296 T-helper 1 cell lineage commitment IEA --
GO:0002829 negative regulation of type 2 immune response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with STAT6: view

Compounds for STAT6 Gene

(28) Novoseek inferred chemical compound relationships for STAT6 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 63 69
ifn-alpha 40.3 2
pd 98,059 37.2 2
mg 132 35.5 1
sb 203580 26.8 1
genes like me logo Genes that share compounds with STAT6: view

Transcripts for STAT6 Gene

Unigene Clusters for STAT6 Gene

Signal transducer and activator of transcription 6, interleukin-4 induced:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - -
SP2:
SP3:
SP4: - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - -
SP8: - - -
SP9:
SP10:
SP11: - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - - -
SP14:
SP15:

ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1: - - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - - - -
SP14:
SP15:

Relevant External Links for STAT6 Gene

GeneLoc Exon Structure for
STAT6
ECgene alternative splicing isoforms for
STAT6

Expression for STAT6 Gene

mRNA expression in normal human tissues for STAT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT6 Gene

This gene is overexpressed in Whole Blood (4.8).

Protein differential expression in normal tissues for STAT6 Gene

This gene is overexpressed in Lymph node (17.0) and Stomach (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAT6 Gene

SOURCE GeneReport for Unigene cluster for STAT6 Gene Hs.524518

genes like me logo Genes that share expressions with STAT6: view

Expression partners for STAT6 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAT6 Gene

Orthologs for STAT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAT6 35
  • 91.34 (n)
  • 92.8 (a)
STAT6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAT6 35
  • 90.4 (n)
  • 91.82 (a)
STAT6 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stat6 35
  • 85.46 (n)
  • 86.02 (a)
Stat6 16
Stat6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAT6 35
  • 98.58 (n)
  • 98.44 (a)
STAT6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stat6 35
  • 85.37 (n)
  • 85.73 (a)
oppossum
(Monodelphis domestica)
Mammalia STAT6 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAT6 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAT6 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stat6 35
  • 58.02 (n)
  • 53.14 (a)
zebrafish
(Danio rerio)
Actinopterygii stat6 35
  • 51.72 (n)
  • 41.78 (a)
stat6 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 37
  • 35 (a)
Stat92E 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 37
  • 29 (a)
sta-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for STAT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT6 Gene

ENSEMBL:
Gene Tree for STAT6 (if available)
TreeFam:
Gene Tree for STAT6 (if available)

Paralogs for STAT6 Gene

Paralogs for STAT6 Gene

genes like me logo Genes that share paralogs with STAT6: view

Variants for STAT6 Gene

Sequence variations from dbSNP and Humsavar for STAT6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs167769 -- 57,109,992(+) CTGGA(C/T)GTTTC intron-variant, utr-variant-5-prime
rs324011 -- 57,108,399(+) GGGAC(C/T)GTCCC intron-variant
rs324012 -- 57,109,198(+) ctctg(C/T)ctcaa intron-variant
rs324015 -- 57,096,317(-) GACAC(A/G)CCCCA utr-variant-3-prime, nc-transcript-variant
rs399685 -- 57,103,056(+) agtag(G/T)gcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAT6 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV Gain 17160897

Relevant External Links for STAT6 Gene

HapMap Linkage Disequilibrium report
STAT6
Human Gene Mutation Database (HGMD)
STAT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT6 Gene

Disorders for STAT6 Gene

(41) Novoseek inferred disease relationships for STAT6 Gene

Disease -log(P) Hits PubMed IDs
asthma allergic 61.9 7
asthma 59.7 29
atopy 51.7 4
severe combined immunodeficiency, x-linked 45.4 1
inflammation 45.3 10

Relevant External Links for STAT6

Genetic Association Database (GAD)
STAT6
Human Genome Epidemiology (HuGE) Navigator
STAT6
genes like me logo Genes that share disorders with STAT6: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for STAT6 Gene

Publications for STAT6 Gene

  1. STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. (PMID: 11912176) Duetsch G. … Wjst M. (Hum. Mol. Genet. 2002) 3 23 48
  2. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. (PMID: 12138096) Litterst C.M. … Pfitzner E. (J. Biol. Chem. 2002) 3 4 23
  3. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. (PMID: 12759487) Tamura K. … Morikawa A. (Int. Arch. Allergy Immunol. 2003) 3 23 48
  4. Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease. (PMID: 12605697) Xia B. … PeA+a A.S. (Clin. Exp. Immunol. 2003) 3 23 48
  5. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PMID: 14757047) Razeto A. … Becker S. (J. Mol. Biol. 2004) 3 4 23

Products for STAT6 Gene

  • Addgene plasmids for STAT6

Sources for STAT6 Gene

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