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Aliases for STAT5B Gene

Aliases for STAT5B Gene

  • Signal Transducer And Activator Of Transcription 5B 2 3
  • Transcription Factor STAT5B 3
  • STAT5 3

External Ids for STAT5B Gene

Previous GeneCards Identifiers for STAT5B Gene

  • GC17U990099
  • GC17M042509
  • GC17M040259
  • GC17M040726
  • GC17M040724
  • GC17M037604
  • GC17M040351
  • GC17M036116

Summaries for STAT5B Gene

Entrez Gene Summary for STAT5B Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAT5B Gene

STAT5B (Signal Transducer And Activator Of Transcription 5B) is a Protein Coding gene. Diseases associated with STAT5B include growth hormone insensitivity with immunodeficiency and laron syndrome with immunodeficiency. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot for STAT5B Gene

  • Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

Gene Wiki entry for STAT5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT5B Gene

Genomics for STAT5B Gene

Regulatory Elements for STAT5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STAT5B Gene

Start:
42,199,168 bp from pter
End:
42,276,707 bp from pter
Size:
77,540 bases
Orientation:
Minus strand

Genomic View for STAT5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT5B Gene

Proteins for STAT5B Gene

  • Protein details for STAT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51692-STA5B_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 5B
    Protein Accession:
    P51692
    Secondary Accessions:
    • Q8WWS8

    Protein attributes for STAT5B Gene

    Size:
    787 amino acids
    Molecular mass:
    89866 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR.

neXtProt entry for STAT5B Gene

Proteomics data for STAT5B Gene at MOPED

Post-translational modifications for STAT5B Gene

  • Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.
  • Ubiquitination at Lys527
  • Modification sites at PhosphoSitePlus

Other Protein References for STAT5B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STAT5B (STAT5B)

No data available for DME Specific Peptides for STAT5B Gene

Domains for STAT5B Gene

Gene Families for STAT5B Gene

HGNC:
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for STAT5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51692

UniProtKB/Swiss-Prot:

STA5B_HUMAN :
  • P51692
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT5B: view

Function for STAT5B Gene

Molecular function for STAT5B Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription 5B,constitutively expressed in peripheral blood lymphocyte,activated by interleukin 2,also expressed in liver fibroblast,activated by GH,maybe involved in GH binding protein positive Laron syndrome children,interacting with T cell receptor and stimulating T cell proliferation
UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

Gene Ontology (GO) - Molecular Function for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding ISS --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with STAT5B: view
genes like me logo Genes that share phenotypes with STAT5B: view

Animal Models for STAT5B Gene

MGI Knock Outs for STAT5B:

Animal Model Products

miRNA for STAT5B Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT5B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STAT5B Gene

Localization for STAT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT5B Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT5B Gene COMPARTMENTS Subcellular localization image for STAT5B gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAT5B: view

Pathways for STAT5B Gene

genes like me logo Genes that share pathways with STAT5B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000255 allantoin metabolic process ISS --
GO:0001553 luteinization IEA --
GO:0001666 response to hypoxia IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with STAT5B: view

Compounds for STAT5B Gene

(1) Drugbank Compounds for STAT5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dasatinib
302962-49-8 target inhibitor

(24) Novoseek inferred chemical compound relationships for STAT5B Gene

Compound -log(P) Hits PubMed IDs
tyrosine 76.8 122
imatinib 46.4 4
aurintricarboxylic acid 46.4 1
gp 130 43.9 2
phosphotyrosine 37 4
genes like me logo Genes that share compounds with STAT5B: view

Transcripts for STAT5B Gene

Unigene Clusters for STAT5B Gene

Signal transducer and activator of transcription 5B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT5B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT5B Gene

No ASD Table

Relevant External Links for STAT5B Gene

GeneLoc Exon Structure for
STAT5B
ECgene alternative splicing isoforms for
STAT5B

Expression for STAT5B Gene

mRNA expression in normal human tissues for STAT5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT5B Gene

This gene is overexpressed in Whole Blood (7.2).

Protein differential expression in normal tissues for STAT5B Gene

This gene is overexpressed in Lymph node (9.4), Peripheral blood mononuclear cells (7.8), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAT5B Gene

SOURCE GeneReport for Unigene cluster for STAT5B Gene Hs.595276

genes like me logo Genes that share expressions with STAT5B: view

Expression partners for STAT5B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAT5B Gene

Orthologs for STAT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAT5B 35
  • 92.59 (n)
  • 97.46 (a)
STAT5B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAT5B 35
  • 92.63 (n)
  • 97.08 (a)
STAT5B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stat5b 35
  • 90.42 (n)
  • 96.95 (a)
Stat5b 16
Stat5b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAT5B 35
  • 96.42 (n)
  • 95.4 (a)
STAT5B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stat5b 35
  • 90.67 (n)
  • 97.46 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves STAT5B 35
  • 82.38 (n)
  • 91.23 (a)
STAT5 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia stat5b 35
  • 77.56 (n)
  • 87.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12087 35
zebrafish
(Danio rerio)
Actinopterygii stat5.1 35
  • 73.03 (n)
  • 79.87 (a)
stat5b 35
stat5.1 36
  • 79 (a)
ManyToMany
stat5.2 36
  • 74 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 37
  • 41 (a)
Stat92E 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 37
  • 29 (a)
sta-1 35
  • 42.12 (n)
  • 32.73 (a)
sta-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3791 36
  • 49 (a)
OneToMany
Species with no ortholog for STAT5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT5B Gene

ENSEMBL:
Gene Tree for STAT5B (if available)
TreeFam:
Gene Tree for STAT5B (if available)

Paralogs for STAT5B Gene

Paralogs for STAT5B Gene

Selected SIMAP similar genes for STAT5B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STAT5B: view

Variants for STAT5B Gene

Sequence variations from dbSNP and Humsavar for STAT5B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15456 -- 42,199,379(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs986254 -- 42,272,983(+) ACATA(A/G)GCTTT intron-variant
rs986255 -- 42,273,048(+) AATAA(A/G)GCCAC intron-variant
rs986256 -- 42,273,308(+) TTTGA(A/G)GACAG intron-variant
rs1046104 -- 42,199,311(-) TAGCC(A/C)CCAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STAT5B Gene

Variant ID Type Subtype PubMed ID
dgv3169n71 CNV Loss 21882294
esv2450397 CNV Deletion 19546169
dgv3170n71 CNV Loss 21882294
nsv908247 CNV Loss 21882294
nsv908248 CNV Loss 21882294
nsv833449 CNV Loss 17160897
esv24591 CNV Loss 19812545

Relevant External Links for STAT5B Gene

HapMap Linkage Disequilibrium report
STAT5B
Human Gene Mutation Database (HGMD)
STAT5B
Locus Specific Mutation Databases (LSDB)
STAT5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT5B Gene

Disorders for STAT5B Gene

(1) OMIM Diseases for STAT5B Gene (604260)

UniProtKB/Swiss-Prot

STA5B_HUMAN
  • Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. {ECO:0000269 PubMed:13679528, ECO:0000269 PubMed:15827093, ECO:0000269 PubMed:22419735}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for STAT5B Gene

(39) Novoseek inferred disease relationships for STAT5B Gene

Disease -log(P) Hits PubMed IDs
laron syndrome 62.8 2
growth failure 60.5 1
idiopathic myelofibrosis 47.6 1
leukemia 46.1 9
leukemia promyelocytic acute 42.8 1

Relevant External Links for STAT5B

Genetic Association Database (GAD)
STAT5B
Human Genome Epidemiology (HuGE) Navigator
STAT5B
genes like me logo Genes that share disorders with STAT5B: view

No data available for Genatlas for STAT5B Gene

Publications for STAT5B Gene

  1. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PMID: 8631883) Lin J.-X. … Leonard W.J. (J. Biol. Chem. 1996) 2 3 4 23
  2. Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. (PMID: 8732682) Silva C.M. … Day R.N. (Mol. Endocrinol. 1996) 3 4 23
  3. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. (PMID: 17639043) Vaclavicek A. … FAPrsti A. (Endocr. Relat. Cancer 2007) 3 23 48
  4. Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PMID: 17997837) Weaver A.M. … Silva C.M. (Breast Cancer Res. 2007) 3 4 23
  5. S731 in the transactivation domain modulates STAT5b activity. (PMID: 17822672) Weaver A.M. … Silva C.M. (Biochem. Biophys. Res. Commun. 2007) 3 23

Products for STAT5B Gene

Sources for STAT5B Gene

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