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Aliases for STAT5B Gene

Aliases for STAT5B Gene

  • Signal Transducer And Activator Of Transcription 5B 2 3
  • Transcription Factor STAT5B 3
  • STAT5 3

External Ids for STAT5B Gene

Previous GeneCards Identifiers for STAT5B Gene

  • GC17U990099
  • GC17M042509
  • GC17M040259
  • GC17M040726
  • GC17M040724
  • GC17M037604
  • GC17M040351
  • GC17M036116

Summaries for STAT5B Gene

Entrez Gene Summary for STAT5B Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAT5B Gene

STAT5B (Signal Transducer And Activator Of Transcription 5B) is a Protein Coding gene. Diseases associated with STAT5B include laron syndrome with immunodeficiency and leukemia, acute promyelocytic, somatic. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot for STAT5B Gene

  • Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

Gene Wiki entry for STAT5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT5B Gene

Genomics for STAT5B Gene

Regulatory Elements for STAT5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STAT5B Gene

Chromosome:
17
Start:
42,199,168 bp from pter
End:
42,276,707 bp from pter
Size:
77,540 bases
Orientation:
Minus strand

Genomic View for STAT5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT5B Gene

Proteins for STAT5B Gene

  • Protein details for STAT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51692-STA5B_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 5B
    Protein Accession:
    P51692
    Secondary Accessions:
    • Q8WWS8

    Protein attributes for STAT5B Gene

    Size:
    787 amino acids
    Molecular mass:
    89866 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR.

neXtProt entry for STAT5B Gene

Proteomics data for STAT5B Gene at MOPED

Post-translational modifications for STAT5B Gene

  • Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAT5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STAT5B (STAT5B)

No data available for DME Specific Peptides for STAT5B Gene

Domains & Families for STAT5B Gene

Gene Families for STAT5B Gene

Suggested Antigen Peptide Sequences for STAT5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51692

UniProtKB/Swiss-Prot:

STA5B_HUMAN :
  • Contains 1 SH2 domain.
  • Belongs to the transcription factor STAT family.
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT5B: view

Function for STAT5B Gene

Molecular function for STAT5B Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription 5B,constitutively expressed in peripheral blood lymphocyte,activated by interleukin 2,also expressed in liver fibroblast,activated by GH,maybe involved in GH binding protein positive Laron syndrome children,interacting with T cell receptor and stimulating T cell proliferation
UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

Gene Ontology (GO) - Molecular Function for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding ISS --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 9989503
genes like me logo Genes that share ontologies with STAT5B: view
genes like me logo Genes that share phenotypes with STAT5B: view

Animal Models for STAT5B Gene

MGI Knock Outs for STAT5B:

Animal Model Products

Transcription Factor Targets for STAT5B Gene

Selected GeneGlobe predicted Target genes for STAT5B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT5B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for STAT5B Gene

Localization for STAT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT5B Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT5B Gene COMPARTMENTS Subcellular localization image for STAT5B gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAT5B: view

Pathways & Interactions for STAT5B Gene

genes like me logo Genes that share pathways with STAT5B: view

PCR Array Products

SIGNOR curated interactions for STAT5B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000255 allantoin metabolic process ISS --
GO:0006101 citrate metabolic process ISS --
GO:0006103 2-oxoglutarate metabolic process ISS --
GO:0006105 succinate metabolic process ISS --
GO:0006107 oxaloacetate metabolic process ISS --
genes like me logo Genes that share ontologies with STAT5B: view

Drugs & Compounds for STAT5B Gene

(14) Drugs for STAT5B Gene - From: NovoSeek, FDA Approved Drugs, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Inhibition, inhibitor, Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 250
Sprycel Approved June 2006 Pharma 0
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 567
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Zinc Approved Pharma 1404

(12) Additional Compounds for STAT5B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
AURINTRICARBOXYLIC ACID
Cycloheximide
Fatty acid
glucose
genes like me logo Genes that share compounds with STAT5B: view

Transcripts for STAT5B Gene

Unigene Clusters for STAT5B Gene

Signal transducer and activator of transcription 5B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT5B Gene

No ASD Table

Relevant External Links for STAT5B Gene

GeneLoc Exon Structure for
STAT5B
ECgene alternative splicing isoforms for
STAT5B

Expression for STAT5B Gene

mRNA expression in normal human tissues for STAT5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT5B Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for STAT5B Gene

This gene is overexpressed in Lymph node (9.4), Peripheral blood mononuclear cells (7.8), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAT5B Gene



SOURCE GeneReport for Unigene cluster for STAT5B Gene Hs.595276

genes like me logo Genes that share expression patterns with STAT5B: view

Protein tissue co-expression partners for STAT5B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAT5B Gene

Orthologs for STAT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAT5B 35
  • 92.59 (n)
  • 97.46 (a)
STAT5B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAT5B 35
  • 92.63 (n)
  • 97.08 (a)
STAT5B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stat5b 35
  • 90.42 (n)
  • 96.95 (a)
Stat5b 16
Stat5b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAT5B 35
  • 96.42 (n)
  • 95.4 (a)
STAT5B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stat5b 35
  • 90.67 (n)
  • 97.46 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves STAT5B 35
  • 82.38 (n)
  • 91.23 (a)
STAT5 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia stat5b 35
  • 77.56 (n)
  • 87.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12087 35
zebrafish
(Danio rerio)
Actinopterygii stat5.1 35
  • 73.03 (n)
  • 79.87 (a)
stat5b 35
stat5.1 36
  • 79 (a)
ManyToMany
stat5.2 36
  • 74 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 37
  • 41 (a)
Stat92E 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 37
  • 29 (a)
sta-1 35
  • 42.12 (n)
  • 32.73 (a)
sta-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3791 36
  • 49 (a)
OneToMany
Species with no ortholog for STAT5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT5B Gene

ENSEMBL:
Gene Tree for STAT5B (if available)
TreeFam:
Gene Tree for STAT5B (if available)

Paralogs for STAT5B Gene

Paralogs for STAT5B Gene

(5) SIMAP similar genes for STAT5B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STAT5B: view

Variants for STAT5B Gene

Sequence variations from dbSNP and Humsavar for STAT5B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15456 -- 42,199,379(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs986256 -- 42,273,308(+) TTTGA(A/G)GACAG intron-variant
rs1046104 -- 42,199,311(-) TAGCC(A/C)CCAAA utr-variant-3-prime
rs1057936 -- 42,207,676(-) TCCAT(C/T)CGGTC synonymous-codon, reference
rs1065376 -- 42,210,256(-) CTACT(C/G)ATTAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for STAT5B Gene

Variant ID Type Subtype PubMed ID
dgv3169n71 CNV Loss 21882294
esv2450397 CNV Deletion 19546169
dgv3170n71 CNV Loss 21882294
nsv908247 CNV Loss 21882294
nsv908248 CNV Loss 21882294
nsv833449 CNV Loss 17160897
esv24591 CNV Loss 19812545

Variation tolerance for STAT5B Gene

Residual Variation Intolerance Score: 13.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAT5B Gene

HapMap Linkage Disequilibrium report
STAT5B
Human Gene Mutation Database (HGMD)
STAT5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT5B Gene

Disorders for STAT5B Gene

MalaCards: The human disease database

(17) MalaCards diseases for STAT5B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
laron syndrome with immunodeficiency
  • laron-like syndrome
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
growth hormone insensitivity with immunodeficiency
  • laron syndrome
chronic leukemia
laron dwarfism
  • laron syndrome
- elite association

UniProtKB/Swiss-Prot

STA5B_HUMAN
  • Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. {ECO:0000269 PubMed:13679528, ECO:0000269 PubMed:15827093, ECO:0000269 PubMed:22419735}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STAT5B

Genetic Association Database (GAD)
STAT5B
Human Genome Epidemiology (HuGE) Navigator
STAT5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAT5B
genes like me logo Genes that share disorders with STAT5B: view

No data available for Genatlas for STAT5B Gene

Publications for STAT5B Gene

  1. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PMID: 8631883) Lin J.-X. … Leonard W.J. (J. Biol. Chem. 1996) 2 23 67
  2. Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells. (PMID: 20372799) Lim E.J. … Yang Y.M. (Int. J. Oncol. 2010) 23 67
  3. Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function. (PMID: 20128689) Wohlmann A. … Friedrich K. (Biol. Chem. 2010) 23 67
  4. Activation of JAK2-V617F by components of heterodimeric cytokine receptors. (PMID: 20363735) Pradhan A. … Reuther G.W. (J. Biol. Chem. 2010) 23 67
  5. Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. (PMID: 20385773) Creamer B.A. … Wagner K.U. (Mol. Cell. Biol. 2010) 23 67

Products for STAT5B Gene

Sources for STAT5B Gene

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