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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAT5B Gene

protein-coding GIFtS: 69
GCID: GC17M040351

signal transducer and activator of transcription 5B

Explore 72 diseases affiliated with
STAT5B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 5B¹ ²
STAT5²
Transcription Factor STAT5B²

External Ids:	HGNC: 11367¹	Entrez Gene: 6777²	Ensembl: ENSG00000173757⁷	OMIM: 604260⁵	UniProtKB: P51692³

Export aliases for STAT5B gene to outside databases

Previous GC identifers: GC17U990099 GC17M042509 GC17M040259 GC17M040726 GC17M040724 GC17M037604 GC17M036116

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT5B:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and

growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or

heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates

the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It

has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland

development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid

receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the

signaling pathways mediated by this protein may be the cause of the APLL. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692

Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses

to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription

Gene Wiki entry for STAT5B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAT5B gene promoter:
GR c-Fos NF-1 NF-1/L AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAT5B promoter sequence

Search SABiosciences Chromatin IP Primers for STAT5B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q11.2

STAT5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT5B gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M040351: view genomic region (about GC identifiers)

Start:	40,351,186 bp from pter	End:	40,428,725 bp from pter
Size:	77,540 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692 (See protein sequence)

Recommended Name: Signal transducer and activator of transcription 5B

Size: 787 amino acids; 89866 Da

Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with

NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in

response to phosphorylation (By similarity)

Secondary accessions: Q8WWS8

Explore the universe of human proteins at neXtProt for STAT5B: NX_P51692

Post-translational modifications:

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine

phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than

constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6

or HCK leads to an increase of its transcriptional activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51692

STAT5B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036580.2

ENSEMBL proteins:

ENSP00000293328 ENSP00000398379

Reactome Protein details: P51692
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant STAT5B Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: STAT5B Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for STAT5B
	GenScript Custom Purified and Recombinant Proteins Services for STAT5B
	Novus Biologicals STAT5B Proteins Novus Biologicals STAT5B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STAT5B

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

STAT5B for ontologies About GeneDecksing

STAT5B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT5B
	R&D Systems Antibodies for STAT5B
	Cell Signaling Technology (CST) Antibodies for STAT5B
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	GenScript Custom Superior Antibodies Services for STAT5B
	Novus Biologicals STAT5B Antibodies
	Abcam antibodies for STAT5B
	Uscn Antibodies for STAT5B
	ThermoFisher Antibodies for STAT5B

Assay Products for STAT5B:

	EMD Millipore Kits and Assays for the Analysis of STAT5B
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for STAT5B (see all)
	GenScript Custom Assay Services for STAT5B
	Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT5B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STAT5B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAT5B for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR013801 STAT_TF_DNA-bd

IPR008967 p53-like_TF_DNA-bd

IPR011992 EF-hand-like_dom

IPR013800 STAT_TF_alpha

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry P51692

ProtoNet protein and cluster: P51692

1 Blocks protein family: IPB001217 STAT protein

UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692

Similarity: Belongs to the transcription factor STAT family

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692

Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses

to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription

Genatlas biochemistry entry for STAT5B:

signal transducer and activator of transcription 5B,constitutively expressed in peripheral blood lymphocyte,activated

by interleukin 2,also expressed in liver fibroblast,activated by GH,maybe involved in GH binding protein positive

Laron syndrome children,interacting with T cell receptor and stimulating T cell proliferation

		10/497 SABiosciences Target genes for STAT5B (see all 497):
		ACAP2 ACAT2 ACOT13 ACOT2 ACP1 ACSM2A ACVR2B ADAD2 ALB ALG1

miRNA Products:		OriGene 3'-UTR Clone: STAT5B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT5B
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT5B (see all 47):
		hsa-miR-3164 hsa-miR-631 hsa-miR-134 hsa-miR-938 hsa-miR-200a hsa-let-7a-2* hsa-miR-507 hsa-miR-548l

		SwitchGear 3'UTR luciferase reporter plasmid: STAT5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT5B (see all 4) OriGene shRNA RFP: STAT5B OriGene siRNA: STAT5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT5B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for STAT5B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAT5B (NM_012448)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STAT5B
		Search LifeMap BioReagents cell lines for STAT5B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT5B

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA	--
GO:0003677	DNA binding	--	--
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004871	signal transducer activity	IEA	--

STAT5B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for STAT5B:

Increased G1 DNA content

Animal Models:
Mouse knock-outs for STAT5B: Stat5b^tm1Jni Stat5a/Stat5b^{Stat5a/tm2.1Mam} Stat5b^tm1Hwd Stat5b^tm2Jni
15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Stat5b) (see all 16):

adipose tissue	behavior/neurological	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	normal	renal/urinary system	reproductive system	respiratory system

STAT5B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/61 super-pathways (see all 61) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IL-9 Signaling Pathways

8/12 pathways (see all 12)
IL-9 Signaling Pathways	1.00	IL-4 Signaling Pathways	0.80
IL-21 Signaling Pathways	0.90	IL-9 Signaling Pathway	0.42
IL-7 Signaling Pathways	0.90	Immune response_IL-9 signaling pathway	0.42
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	0.90	Immune response IL-9 signaling pathway	0.42

Development_PDGF signaling via STATs and NF-kB

8/10 pathways (see all 10)
Development_PDGF signaling via STATs and NF-kB	1.00	Development Angiopoietin - Tie2 signaling	0.38
Development PDGF signaling via STATs and NF-kB	1.00	Immune response_IL-10 signaling pathway	0.28
Immune response_IL-23 signaling pathway	0.44	Immune response IL-10 signaling pathway	0.28
Immune response IL-23 signaling pathway	0.41	Angiopoietin-TIE2 Signaling	0.13

ErbB4 Pathway

Prolactin Signaling	0.54	Thrombopoietin Pathway	0.43
ErbB2-ErbB3 Heterodimers	0.47	Growth Hormone Signaling	0.32
IL-2 Pathway	0.46

Development_Prolactin receptor signaling

	Development_Prolactin receptor signaling	1.00			Prolactin Signaling Pathway	0.39
	Development Prolactin receptor signaling	1.00			Leptin signaling pathway	0.32

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 EMD Millipore Pathways for STAT5B (see all 15)

	Development Angiopoietin - Tie2 signaling
	Immune response IL-23 signaling pathway
	Immune response IL-9 signaling pathway
	Development EPO-induced Jak-STAT pathway
	Immune response IL-3 activation and signaling pathway

5/9 R&D Systems Pathways for STAT5B (see all 9)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-4 Signaling Pathways
	IL-7 Signaling Pathways
	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT5B (see all 21)

	FLT3 Signaling
	MAPK Signaling
	PDGF Pathway
	IL-2 Pathway
	Tec Kinases Signaling

1 Cell Signaling Technology (CST) Pathway for STAT5B

Jak/Stat Pathway

5/15 GeneGo (Thomson Reuters) Pathways for STAT5B (see all 15)

	Development Endothelin-1/EDNRA transactivation of EGFR
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Immune response IL-9 signaling pathway
	Immune response IL-10 signaling pathway
	Immune response IL-2 activation and signaling pathway

5/27 BioSystems Pathways for STAT5B (see all 27)

	Oncostatin M Signaling Pathway
	AGE/RAGE pathway
	EPO Receptor Signaling
	Adipogenesis
	EGFR1 Signaling Pathway

5/22 Reactome Pathways for STAT5B (see all 22)

	Prolactin receptor signaling
	Signaling by FGFR1 mutants
	Disease
	Downstream signal transduction
	Signal Transduction

1 PharmGKB Pathway for STAT5B

EGFR Inhibitor Pathway, Pharmacodynamics

5/7 Kegg Pathways (Kegg details for STAT5B) (see all 7):

	ErbB signaling pathway
	Chemokine signaling pathway
	Jak-STAT signaling pathway
	Measles
	Pathways in cancer

STAT5B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STAT5B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/78 Interacting proteins for STAT5B (P51692^{1, 2, 3} ENSP00000293328⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 78)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAP2	Q9UGK3²^,³, ENSP00000317912⁴	MINT-58271 MINT-58270 MINT-58259 MINT-58256 MINT-58275 MINT-58255 MINT-58269 MINT-58268 MINT-58276 MINT-58260 I2D: score=2 STRING: ENSP00000317912
NMI	Q13287¹^,³, ENSP00000243346⁴	EBI-1186119,EBI-372942 I2D: score=5 STRING: ENSP00000243346
IL2RB	P14784²^,³, ENSP00000216223⁴	MINT-8035171 I2D: score=4 STRING: ENSP00000216223
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-61485 MINT-61490 I2D: score=6 STRING: ENSP00000275493
INSR	P06213²^,³, ENSP00000303830⁴	MINT-8026203 I2D: score=3 STRING: ENSP00000303830

About this table

Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000255	allantoin metabolic process	ISS	--
GO:0001553	luteinization	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0001779	natural killer cell differentiation	IEA	--
GO:0001889	liver development	IEA	--

STAT5B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

STAT5B for compounds About GeneDecksing

EMD Millipore small molecules for STAT5B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAT5B

1 DrugBank Compound for STAT5B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dasatinib	--	302962-49-8	target	inhibitor	17431118 17020995

10/24 Novoseek chemical compound relationships for STAT5B gene (see all 24) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	76.8	154	8923468 (4), 10421786 (3), 9122188 (3), 10428824 (3) (see all 97)
imatinib	46.4	5	14604282 (1), 14646349 (1), 15790786 (1), 11675355 (1)
aurintricarboxylic acid	46.4	1	9417042 (1)
gp 130	43.9	2	7559477 (1), 18430728 (1)
phosphotyrosine	37	6	8943229 (1), 18258175 (1), 11896598 (1), 16584384 (1)
serine	36.6	26	9804779 (4), 11731617 (3), 12407017 (2), 9182578 (2) (see all 13)
retinoic acid	29.2	4	17951529 (1), 11929748 (1), 11929749 (1), 9218607 (1)
estrogen	24.4	15	12642867 (3), 12411447 (2), 16954437 (2), 12459712 (2) (see all 8)
rapamycin	23.1	3	15514005 (1), 17005643 (1)
ly294002	19	4	18325115 (1), 15514005 (1), 16840725 (1)

Search CenterWatch for drugs/clinical trials and news about STAT5B / STA5B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAT5B gene:

NM_012448.3

Unigene Cluster for STAT5B:

Signal transducer and activator of transcription 5B

Hs.743995 [show with all ESTs]

Unigene Representative Sequence: NM_012448

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000293328(uc002hzh.3) ENST00000498674 ENST00000481253 ENST00000468496

ENST00000481517 ENST00000468312(uc002hzi.3) ENST00000415845

miRNA Products:		OriGene 3'-UTR Clone: STAT5B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT5B
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT5B (see all 47):
		hsa-miR-3164 hsa-miR-631 hsa-miR-134 hsa-miR-938 hsa-miR-200a hsa-let-7a-2* hsa-miR-507 hsa-miR-548l

		SwitchGear 3'UTR luciferase reporter plasmid: STAT5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT5B (see all 4) OriGene shRNA RFP: STAT5B OriGene siRNA: STAT5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT5B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAT5B (NM_012448)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT5B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STAT5B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT5B

Additional cDNA sequence:

AB208920.1 AK308163.1 AL080218.1 BC020868.1 BC029072.1 BC065227.1 U47686.1 U48730.2

12 DOTS entries:

DT.92408299 DT.97839095 DT.100831942 DT.92030713 DT.92057069 DT.100648005 DT.100710021 DT.120933990

DT.91852995 DT.95174042 DT.99932448 DT.316707

24/278 AceView cDNA sequences (see all 278):

CD679012 AL602639 BE252109 BQ932442 BU726298 BM825216 BE906444 NM_012448

AI362731 AL049139 BM450408 CB215020 AI082457 BM449533 AL598273 T90203

BM989804 BC065227 BQ436112 BX401753 BQ706430 BE859047 AL601551 CD515883

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAT5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGATGGGTG

About this image
See STAT5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAT5B

SOURCE GeneReport for Unigene cluster: Hs.743995

SABiosciences Expression via Pathway-Focused PCR Arrays including STAT5B (see all 6):

NFKB Signaling Targets in human mouse rat

Leukemia in human mouse rat

Transcription Factors in human mouse rat

Apoptosis 384HT in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT5B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STAT5B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT5B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT5B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STAT5B gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STAT5B¹	signal transducer and activator of transcription 5B	82.38(n) 91.23(a)		395556 NM_204779.1 NP_990110.1
lizard (Anolis carolinensis)	Reptilia	--	--	87(a)	1 → many	6(72644312-72675710)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12087²	Xenopus laevis STAT5 mRNA, complete cds	77.9(n)		AF382190.1
zebrafish (Danio rerio)	Actinopterygii	stat5b²	signal transducer and activator of transcription 5B	77.14(n)		369197 AF338447.1
fruit fly (Drosophila melanogaster)	Insecta	Stat92E³	signal transduction transcription factor	41(a)		3 92F1 --
worm (Caenorhabditis elegans)	Secernentea	Y51H4A.17³ sta-1¹	Protein STA-1¹	29(a)³ 42.2(n)¹ 31.7(a)¹		IV(16664481-16671418)³ 178465¹ NM_001129343.1¹ NP_001122815.1¹

ENSEMBL Gene Tree for STAT5B (if available)
TreeFam Gene Tree for STAT5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAT5B gene

STAT1² STAT4² STAT2² STAT6² STAT3² STAT5A²

5 SIMAP similar genes for STAT5B using alignment to 2 protein entries: STA5B_HUMAN (see all proteins):

STAT5A STAT4 STAT1 STAT3 STAT6

STAT5B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150471741^1,2	C,	unknown	38160889(+)	`ACTTAC/TTCTCA`	1	--	int¹		0	--	--	--	--
rs1046104^1,2	C,H	--	36116364(-)	`TAGCCA/CCCAAA`	1	--	ut3¹ ese³		6		NS EA NA	422
rs15456^1,2	C	--	36116432(+)	`AAAAAG/AAAAAA`	1	--	ut3¹		1		NA	2
rs113234237^1,2	C,F,	--	36116623(+)	`GAACAA/GGGAGG`	1	--	ut3¹		3		CSA WA	122
rs112972196^1,2	C	--	36117102(+)	`AGCCTA/C/GCTCCT`	2	--	ut3¹		1		CSA	1
rs78682061^1,2	C,F,	--	36117616(+)	`GACCCG/ACTAAG`	1	--	ut3¹		1		WA	118
rs113824843^1,2	C,	--	36117897(+)	`CAGCCG/AGAACA`	1	--	ut3¹		2		CSA WA	120
rs75341760^1,2	C,F,	--	36118460(+)	`CTTCAC/TGAAAC`	1	--	ut3¹		1		WA	118
rs34320895^1,2	C	--	36118722(+)	`CATGGA/GATTAA`	1	--	ut3¹		0	--	--	--	--
rs80230274^1,2	F,	--	36119094(+)	`AATACC/TCTCCC`	1	--	int¹		3		CSA WA	122

HapMap Linkage Disequilibrium report for STAT5B (40351186 - 40428725 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STAT5B
2 CNVs: 67200 102459
Human Gene Mutation Database (HGMD): STAT5B

Locus Specific Mutation Databases (LSDB): STAT5B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAT5B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STAT5B for disorders           About GeneDecksing

OMIM gene information: 604260
OMIM disorders: 245590
UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692

Defects in STAT5B are the cause of growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]. A

disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating

concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections

20/72 diseases for STAT5B (see all 72): About MalaCards

acute promyelocytic leukemia insulin-like growth factor i deficiency estrogen-receptor positive breast cancer leukemia

human t-cell leukemia virus type 1 cleft lip/palate growth hormone insensitivity with immunodeficiency severe combined immunodeficiency

non-small cell lung carcinoma short stature growth hormone deficiency laron syndrome

anaplastic large cell lymphoma cleft lip combined immunodeficiency myeloid leukemia

pediatric crohns disease myeloproliferative disorder essential thrombocythemia lymphoblastic leukemia

2 diseases from the University of Copenhagen DISEASES database for STAT5B:

Leukemia Laron syndrome

10/39 Novoseek disease relationships for STAT5B gene (see all 39) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
laron syndrome	62.8	2	17030597 (1), 17986822 (1)
growth failure	60.5	2	15827093 (1)
idiopathic myelofibrosis	47.6	1	17376889 (1)
leukemia	46.1	10	18638462 (1), 20201032 (1), 15677477 (1), 16532027 (1) (see all 9)
leukemia promyelocytic acute	42.8	1	11929749 (1)
hematopoietic malignancies	41.1	7	15298729 (1), 12459712 (1), 11973644 (1), 12642867 (1)
thrombocythemia essential	41	2	16923108 (1), 17376889 (1)
myeloproliferative disorders	39.2	1	17218386 (1)
breast cancer	38	92	17997837 (7), 19630967 (7), 15169792 (5), 16954437 (5) (see all 23)
leukemogenesis	35.1	3	10706877 (1), 11929748 (1), 16585210 (1)

Human Genome Epidemiology (HuGE) Navigator: STAT5B (14 documents)

Export disorders for STAT5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STAT5B gene, integrated from 9 sources (see all 523):
(articles sorted by number of sources associating them with STAT5B)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PubMed id 8631883)^{1, 2, 3, 9} Lin J.-X.... Leonard W.J. (1996)
Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PubMed id 17997837)^{1, 2, 9} Weaver A.M. and Silva C.M. (2007)
Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. (PubMed id 8732682)^{1, 2, 9} Silva C.M.... Day R.N. (1996)
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)^{1, 2, 9} Litterst C.M.... Pfitzner E. (2003)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)^{1, 2} Martens N....Gertler A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Growth hormone insensitivity associated with a STAT5b mutation. (PubMed id 13679528)^{1, 2} Kofoed E.M....Rosenfeld R.G. (2003)
The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter. (PubMed id 12039059)^{1, 2} Ambrosio R.... Ursini M.V. (2002)
Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. (PubMed id 9989503)^{1, 2} Zhu M.-H.... Leonard W.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6777	HGNC: 11367	AceView: STAT5B	Ensembl:ENSG00000173757	euGenes: HUgn6777
ECgene: STAT5B	Kegg: 6777	H-InvDB: STAT5B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAT5B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for STAT5B	Genetics and Cytogenetics in Oncology and Haematology
STAT5Bbase	http://bioinf.uta.fi/STAT5Bbase/
Wikipedia	http://en.wikipedia.org/wiki/STAT5

Intellectual Property for STAT5B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAT5B gene:
Search GeneIP for patents involving STAT5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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signal transducer and activator of transcription 5B

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STAT5B Gene

signal transducer and activator of transcription 5B

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