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STAT5B Gene

protein-coding   GIFtS: 73
GCID: GC17M040351

Signal Transducer And Activator Of Transcription 5B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducer And Activator Of Transcription 5B1 2
STAT52
Transcription Factor STAT5B2

External Ids:    HGNC: 113671   Entrez Gene: 67772   Ensembl: ENSG000001737577   OMIM: 6042605   UniProtKB: P516923   

Export aliases for STAT5B gene to outside databases

Previous GC identifers: GC17U990099 GC17M042509 GC17M040259 GC17M040726 GC17M040724 GC17M037604 GC17M036116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAT5B Gene:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines
and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form
homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This
protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different
growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling,
apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found
to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).
The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. (provided by
RefSeq, Jul 2008)

GeneCards Summary for STAT5B Gene:
STAT5B (signal transducer and activator of transcription 5B) is a protein-coding gene. Diseases associated with STAT5B include leukemia, acute promyelocytic, stat5b/rara type, and growth hormone insensitivity with immunodeficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692
Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular
responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced
transcription

Gene Wiki entry for STAT5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAT5B gene promoter:
         GR   c-Fos   NF-1   NF-1/L   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAT5B promoter sequence
   Search Chromatin IP Primers for STAT5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q11.2

STAT5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT5B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040351:  view genomic region     (about GC identifiers)

Start:
40,351,186 bp from pter      End:
40,428,725 bp from pter
Size:
77,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 5B  
Size: 787 amino acids; 89866 Da
Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts
with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR
Secondary accessions: Q8WWS8

Explore the universe of human proteins at neXtProt for STAT5B: NX_P51692

Explore proteomics data for STAT5B at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus.
    Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker
    phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2.
    Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation
    on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway1
  • Ubiquitination2 at Lys527
  • Modification sites at PhosphoSitePlus

  • See STAT5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036580.2  
    ENSEMBL proteins: 
     ENSP00000293328   ENSP00000398379  
    Reactome Protein details: P51692

    STAT5B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAT5B
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for STAT5B
    OriGene Custom Protein Services for STAT5B
    GenScript Custom Purified and Recombinant Proteins Services for STAT5B
    Novus Biologicals STAT5B Proteins
    Novus Biologicals STAT5B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT5B

    STAT5B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT5B
    R&D Systems Antibodies for STAT5B
    Cell Signaling Technology (CST) Antibodies for STAT5B 
    OriGene Antibodies for STAT5B
    OriGene Custom Antibody Services for STAT5B
    Novus Biologicals STAT5B Antibodies
    Abcam antibodies for STAT5B (P51692, P42229)
    Cloud-Clone Corp. Antibodies for STAT5B
    ThermoFisher Antibodies for STAT5B
    LSBio Antibodies in human, mouse, rat for STAT5B

    STAT5B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAT5B
    R&D Systems ELISAs for STAT5B         (see all)
    GenScript Custom Assay Services for STAT5B
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT5B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT5B
    Cloud-Clone Corp. CLIAs for STAT5B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 9):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-dom_pair
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P51692

    ProtoNet protein and cluster: P51692

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    STAT5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STA5B_HUMAN, P51692
    Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular
    responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced
    transcription

         Genatlas biochemistry entry for STAT5B:
    signal transducer and activator of transcription 5B,constitutively expressed in peripheral blood
    lymphocyte,activated by interleukin 2,also expressed in liver fibroblast,activated by GH,maybe involved in GH
    binding protein positive Laron syndrome children,interacting with T cell receptor and stimulating T cell
    proliferation

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding ISS--
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    STAT5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STAT5B:
     Increased G1 DNA content 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Stat5b) (see all 16):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  normal  renal/urinary system  reproductive system  respiratory system 

    STAT5B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STAT5B: Stat5btm1Jni Stat5a/Stat5bStat5a/tm2.1Mam Stat5btm1Hwd Stat5btm2Jni Stat5btm1(KOMP)Vlcg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAT5B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAT5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT5B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT5B

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT5B:
    hsa-mir-23b-3p (MIRT023476), hsa-mir-324-3p (MIRT042849), hsa-mir-1229-3p (MIRT036362), hsa-mir-93-3p (MIRT038811)

    Block miRNA regulation of human, mouse, rat STAT5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAT5B (see all 47):
    hsa-miR-3164 hsa-miR-631 hsa-miR-134 hsa-miR-938 hsa-miR-200a hsa-let-7a-2* hsa-miR-507 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSTAT5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAT5B
    Predesigned siRNA for gene silencing in human, mouse, rat STAT5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT5B

    Clone
    Products:
         
    OriGene clones in human, mouse for STAT5B (see all 7)
    OriGene ORF clones in mouse, rat for STAT5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAT5B (NM_012448)
    Sino Biological Human cDNA Clone for STAT5B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT5B
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAT5B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STA5B_HUMAN, P51692: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in
    response to phosphorylation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--

    STAT5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAT5B About   (see all 63)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    2Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    Immune response IL 10 signaling pathway0.38
    Development PDGF signaling via STATs and NF kB0.41
    Angiopoietin-TIE2 Signaling0.36
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    3Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    4Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    EPO Receptor Signaling0.42
    5ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for STAT5B (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    IL-7 Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STAT5B (see all 21)
        FLT3 Signaling
    MAPK Signaling
    PDGF Pathway
    IL-2 Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for STAT5B
        Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for STAT5B (see all 15)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway
    Immune response IL-10 signaling pathway
    Immune response IL-2 activation and signaling pathway

    Selected BioSystems Pathways for STAT5B (see all 28)
        EGFR1 Signaling Pathway
    Adipogenesis
    EPO Receptor Signaling
    AGE/RAGE pathway
    Oncostatin M Signaling Pathway


    Selected Reactome Pathways for STAT5B (see all 9)
        Prolactin receptor signaling
    Interleukin-7 signaling
    Downstream signal transduction
    Interleukin-2 signaling
    Interleukin-3, 5 and GM-CSF signaling

    1 PharmGKB Pathway for STAT5B
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for STAT5B) (see all 11):
        ErbB signaling pathway
    Chemokine signaling pathway
    Jak-STAT signaling pathway
    Prolactin signaling pathway
    Hepatitis B


    STAT5B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT5B (see all 6): 
              NFKB Signaling Targets in human mouse rat
              Leukemia in human mouse rat
              Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAT5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAT5B (P516921, 2, 3 ENSP000002933284) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAP2Q9UGK32, 3MINT-58271 MINT-58270 MINT-58259 MINT-58275 MINT-58256 MINT-58255 MINT-58269 MINT-58268 MINT-58276 MINT-58260 I2D: score=2 
    NMIQ132871, 3, ENSP000002433464EBI-1186119,EBI-372942 I2D: score=5 STRING: ENSP00000243346
    IL2RBP147842, 3, ENSP000002162234MINT-8035171 I2D: score=4 STRING: ENSP00000216223
    EGFRP005332, 3, ENSP000002754934MINT-61485 MINT-61490 I2D: score=6 STRING: ENSP00000275493
    INSRP062132, 3, ENSP000003038304MINT-8026203 I2D: score=3 STRING: ENSP00000303830
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 65):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000255allantoin metabolic process ISS--
    GO:0001553luteinization IEA--
    GO:0001666response to hypoxia IEA--
    GO:0001779natural killer cell differentiation IEA--
    GO:0001889liver development IEA--

    STAT5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAT5B (STA5B)

    1 DrugBank Compound for STAT5B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetinhibitor17431118 17020995

    Selected Novoseek inferred chemical compound relationships for STAT5B gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.8 154 8923468 (4), 10421786 (3), 9122188 (3), 10428824 (3) (see all 97)
    imatinib 46.4 5 14604282 (1), 14646349 (1), 15790786 (1), 11675355 (1)
    aurintricarboxylic acid 46.4 1 9417042 (1)
    gp 130 43.9 2 7559477 (1), 18430728 (1)
    phosphotyrosine 37 6 8943229 (1), 18258175 (1), 11896598 (1), 16584384 (1)
    serine 36.6 26 9804779 (4), 11731617 (3), 12407017 (2), 9182578 (2) (see all 13)
    retinoic acid 29.2 4 17951529 (1), 11929748 (1), 11929749 (1), 9218607 (1)
    estrogen 24.4 15 12642867 (3), 12411447 (2), 16954437 (2), 12459712 (2) (see all 8)
    rapamycin 23.1 3 15514005 (1), 17005643 (1)
    ly294002 19 4 18325115 (1), 15514005 (1), 16840725 (1)



    STAT5B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for STAT5B gene: 
    NM_012448.3  

    Unigene Cluster for STAT5B:

    Signal transducer and activator of transcription 5B
    Hs.595276  [show with all ESTs]
    Unigene Representative Sequence: NM_012448
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293328(uc002hzh.3) ENST00000498674 ENST00000481253 ENST00000468496
    ENST00000481517 ENST00000468312(uc002hzi.3) ENST00000415845
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STAT5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAT5B (see all 47):
    hsa-miR-3164 hsa-miR-631 hsa-miR-134 hsa-miR-938 hsa-miR-200a hsa-let-7a-2* hsa-miR-507 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSTAT5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAT5B
    Predesigned siRNA for gene silencing in human, mouse, rat STAT5B
    Clone
    Products:
         
    OriGene clones in human, mouse for STAT5B (see all 7)
    OriGene ORF clones in mouse, rat for STAT5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAT5B (NM_012448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAT5B
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT5B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT5B
      QuantiTect SYBR Green Assays in human, mouse, rat STAT5B
      QuantiFast Probe-based Assays in human, mouse, rat STAT5B

    Additional mRNA sequence: 

    AB208920.1 AK308163.1 AL080218.1 BC020868.1 BC029072.1 BC065227.1 U47686.1 U48730.2 

    12 DOTS entries:

    DT.92408299  DT.97839095  DT.92057069  DT.100831942  DT.92030713  DT.100648005  DT.100710021  DT.120933990 
    DT.91852995  DT.95174042  DT.99932448  DT.316707 

    Selected AceView cDNA sequences (see all 278):

    BX427446 BQ941072 AI149535 NM_012448 BU726298 BM449533 BX401753 BM450408 
    AL049139 AI362731 AI218242 BE252109 AA985088 BQ436112 CD679012 BC029072 
    BM825216 AL598273 AI436810 AI082457 CB215020 T90203 BQ932442 BQ706430 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    STAT5B expression in normal human tissues (normalized intensities)      STAT5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGGGTG
    STAT5B Expression
    About this image


    STAT5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)
     
     Uterus (Reproductive System)
    STAT5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAT5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595276
        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT5B (see all 6): 
              NFKB Signaling Targets in human mouse rat
              Leukemia in human mouse rat
              Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STAT5B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat5b1 , 5 signal transducer and activator of transcription 5B1, 5 90.42(n)1
    96.95(a)1
      11 (63.63 cM)5
    208511  NM_011489.31  NP_035619.31 
     1007807315 
    chicken
    (Gallus gallus)
    Aves STAT5B1 signal transducer and activator of transcription 5B 82.38(n)
    91.23(a)
      395556  NM_204779.1  NP_990110.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 → many
    6(72573138-72675710)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120872 Xenopus laevis STAT5 mRNA, complete cds 77.9(n)    AF382190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stat5b2 signal transducer and activator of transcription 5B 77.14(n)   369197  AF338447.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stat92E3 signal transduction transcription
    factor
    41(a)   3 92F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H4A.173
    sta-11
    sta-11 29(a)3
    42.12(n)1
    32.73(a)1
      IV(16664481-16671418)3
    1784651  NM_070573.41  NP_502974.21 


    ENSEMBL Gene Tree for STAT5B (if available)
    TreeFam Gene Tree for STAT5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAT5B gene
    STAT12  STAT42  STAT22  STAT32  STAT62  STAT5A2  
    5 SIMAP similar genes for STAT5B using alignment to 2 protein entries:     STA5B_HUMAN (see all proteins):
    STAT5A    STAT4    STAT1    STAT3    STAT6

    STAT5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAT5B (see all 1451)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0187284
    Growth hormone insensitivity with immunodeficiency (GHII)4--see VAR_0187282 A P mis40--------
    VAR_0673684
    Growth hormone insensitivity with immunodeficiency (GHII)4--see VAR_0673682 F S mis40--------
    rs1504717411,2
    Cuntested141190655(+) ACTTAC/TTCTCA 1 -- int10--------
    rs113462491,2
    C--36160065(+) AGGGT-/CCCTCT 1 -- int10--------
    rs114434741,2
    C--36160236(+) TACTT-/TAAAAA 1 -- int10--------
    rs1882312611,2
    --36160984(+) ATGGAA/TTTGCG 1 -- int10--------
    rs2013126931,2
    C--36161155(+) TTTTC-/TTTTTT 1 -- int10--------
    rs1996710711,2
    C--36165015(+) TCTCT-/AAAAAA 1 -- int10--------
    rs30481661,2
    C--36170170(-) GAAAG-/AAAG  
            
    GTTCA
    1 -- int10--------
    rs567023791,2
    C--36174442(+) CAAAC-/AGGGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for STAT5B (40351186 - 40428725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for STAT5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2450397CNV Deletion19546169
    esv24591CNV Loss19812545
    nsv908248CNV Loss21882294
    dgv3170n71CNV Loss21882294
    dgv3169n71CNV Loss21882294
    nsv833449CNV Loss17160897
    nsv908247CNV Loss21882294

    Human Gene Mutation Database (HGMD): STAT5B
    Locus Specific Mutation Databases (LSDB): STAT5B

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604260   
    OMIM disorders: 245590  
    UniProtKB/Swiss-Prot: STA5B_HUMAN, P51692
  • Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short
    stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth
    hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • Selected diseases for STAT5B (see all 68):    About MalaCards
    leukemia, acute promyelocytic, stat5b/rara type    growth hormone insensitivity with immunodeficiency    primary cutaneous anaplastic large cell lymphoma    laron syndrome
    acute promyelocytic leukemia    estrogen-receptor positive breast cancer    chronic myeloproliferative disease    myelofibrosis
    systemic mastocytosis    lymphoblastic lymphoma    hyperprolactinemia    paroxysmal nocturnal hemoglobinuria
    hemoglobinuria    mastocytosis    large granular lymphocyte leukemia    short stature
    anaplastic large cell lymphoma    essential thrombocythemia    severe combined immunodeficiency    myeloproliferative disorder

    2 diseases from the University of Copenhagen DISEASES database for STAT5B:
    Leukemia     Laron syndrome

    STAT5B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for STAT5B gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laron syndrome 62.8 2 17030597 (1), 17986822 (1)
    growth failure 60.5 2 15827093 (1)
    idiopathic myelofibrosis 47.6 1 17376889 (1)
    leukemia 46.1 10 18638462 (1), 20201032 (1), 15677477 (1), 16532027 (1) (see all 9)
    leukemia promyelocytic acute 42.8 1 11929749 (1)
    hematopoietic malignancies 41.1 7 15298729 (1), 12459712 (1), 11973644 (1), 12642867 (1)
    thrombocythemia essential 41 2 16923108 (1), 17376889 (1)
    myeloproliferative disorders 39.2 1 17218386 (1)
    breast cancer 38 92 17997837 (7), 19630967 (7), 15169792 (5), 16954437 (5) (see all 23)
    leukemogenesis 35.1 3 10706877 (1), 11929748 (1), 16585210 (1)

    Genetic Association Database (GAD): STAT5B
    Human Genome Epidemiology (HuGE) Navigator: STAT5B (14 documents)

    Export disorders for STAT5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAT5B gene, integrated from 10 sources (see all 551):
    (articles sorted by number of sources associating them with STAT5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PubMed id 8631883)1, 2, 3, 9 Lin J.-X.... Leonard W.J. (J. Biol. Chem. 1996)
    2. Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PubMed id 17997837)1, 2, 9 Weaver A.M. and Silva C.M. (Breast Cancer Res. 2007)
    3. Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. (PubMed id 8732682)1, 2, 9 Silva C.M.... Day R.N. (Mol. Endocrinol. 1996)
    4. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon I+. (PubMed id 20065083)1, 4, 9 Kreil S....Cross N.C. (Haematologica 2010)
    5. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. (PubMed id 17639043)1, 4, 9 Vaclavicek A....FAPrsti A. (Endocr. Relat. Cancer 2007)
    6. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)1, 2, 9 Litterst C.M.... Pfitzner E. (J. Biol. Chem. 2003)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia. (PubMed id 20716621)1, 4 Chang J.S....Buffler P.A. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6777 HGNC: 11367 AceView: STAT5B Ensembl:ENSG00000173757 euGenes: HUgn6777
    ECgene: STAT5B Kegg: 6777 H-InvDB: STAT5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAT5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT5B Genetics and Cytogenetics in Oncology and Haematology
    STAT5Bbasehttp://bioinf.uta.fi/STAT5Bbase/
    Wikipedia http://en.wikipedia.org/wiki/STAT5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAT5B gene:
    Search GeneIP for patents involving STAT5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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