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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAT5A Gene

protein-coding GIFtS: 70
GCID: GC17P040439

signal transducer and activator of transcription 5A

(Previous symbol: STAT5)

Explore 84 diseases affiliated with
STAT5A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 5A¹ ²
STAT5¹ ² ³
MGF¹ ²

External Ids:	HGNC: 11366¹	Entrez Gene: 6776²	Ensembl: ENSG00000126561⁷	OMIM: 601511⁵	UniProtKB: P42229³

Export aliases for STAT5A gene to outside databases

Previous GC identifers: GC17M039918 GC17P042595 GC17P040348 GC17P040812 GC17P037694 GC17P036204

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT5A:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and

growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or

heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is

activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin,

thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a

TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The

mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic

function of this gene in cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229

Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses

to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular

responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced

transcription. Regulates the expression of milk proteins during lactation

Gene Wiki entry for STAT5A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAT5A gene promoter:
GR c-Fos NF-1 NF-1/L AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STAT5A promoter sequence

Search SABiosciences Chromatin IP Primers for STAT5A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT5A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q11.2

STAT5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT5A gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P040439: view genomic region (about GC identifiers)

Start:	40,439,565 bp from pter	End:	40,463,961 bp from pter
Size:	24,397 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229 (See protein sequence)

Recommended Name: Signal transducer and activator of transcription 5A

Size: 794 amino acids; 90647 Da

Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with

NCOA1 and SOCS7. Interacts with ERBB4

Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation

Explore the universe of human proteins at neXtProt for STAT5A: NX_P42229

Post-translational modifications:

Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated

KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated

in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for

DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity

(By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much

weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at

Tyr-694¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P42229

STAT5A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003143.2

ENSEMBL proteins:

ENSP00000341208 ENSP00000468749 ENSP00000443107 ENSP00000464730 ENSP00000407327

ENSP00000465437 ENSP00000466320 ENSP00000400320

Reactome Protein details: P42229
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant STAT5A Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: STAT5A OriGene Protein Over-expression Lysate: STAT5A OriGene Custom Protein Services for STAT5A
	GenScript Custom Purified and Recombinant Proteins Services for STAT5A
	Novus Biologicals STAT5A Proteins Novus Biologicals STAT5A Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STAT5A

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--

STAT5A for ontologies About GeneDecksing

STAT5A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT5A
	R&D Systems Antibodies for STAT5A
	Cell Signaling Technology (CST) Antibodies for STAT5A
	OriGene Antibodies (see all 21): STAT5A OriGene Custom Antibody Services for STAT5A
	GenScript Custom Superior Antibodies Services for STAT5A
	Novus Biologicals STAT5A Antibodies
	Abcam antibodies for STAT5A
	Uscn Antibodies for STAT5A
	ThermoFisher Antibodies for STAT5A

Assay Products for STAT5A:

	EMD Millipore Kits and Assays for the Analysis of STAT5A
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for STAT5A (see all)
	GenScript Custom Assay Services for STAT5A
	Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT5A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STAT5A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAT5A for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR013801 STAT_TF_DNA-bd

IPR008967 p53-like_TF_DNA-bd

IPR011992 EF-hand-like_dom

IPR013800 STAT_TF_alpha

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry P42229

ProtoNet protein and cluster: P42229

1 Blocks protein family: IPB001217 STAT protein

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229

Similarity: Belongs to the transcription factor STAT family

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229

Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses

to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular

responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced

transcription. Regulates the expression of milk proteins during lactation

Genatlas biochemistry entry for STAT5A:

signal transducer and activator of transcription 5A of the GH JAK/STAT pathway,constitutively expressed in peripheral

blood lymphocytes,activated by a variety of hormones and cytokines including interleukin 2,interacting with T cell

receptor and stimulating T cell proliferation

		10/998 SABiosciences Target genes for STAT5A (see all 998):
		A2M ABHD13 ACAP3 ACCSL ACO2 ACP5 ACRBP ACSL5 ACSM2A ACSS1

miRNA Products:		miRTarBase miRNAs that target STAT5A: hsa-mir-222 (MIRT000018)

		OriGene 3'-UTR Clone: STAT5A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT5A
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT5A:
		hsa-miR-3163 hsa-miR-466 hsa-miR-520d-5p hsa-miR-548k hsa-miR-524-5p hsa-miR-3941
		SwitchGear 3'UTR luciferase reporter plasmid: STAT5A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT5A (see all 4) OriGene shRNA RFP: STAT5A OriGene siRNA: STAT5A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT5A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for STAT5A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAT5A (NM_003152)
		Sino Biological Human cDNA Clone for STAT5A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STAT5A
		Search LifeMap BioReagents cell lines for STAT5A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT5A

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA	--
GO:0003677	DNA binding	--	--
GO:0003690	double-stranded DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004871	signal transducer activity	IEA	--

STAT5A for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for STAT5A:

Decreased Wnt reporter activit

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for STAT5A: Stat5a^tm1Mam Stat5a/Stat5b^{Stat5a/tm2.1Mam} Stat5a^tm1Jni
15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Stat5a):

adipose tissue	behavior/neurological	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	normal	reproductive system	respiratory system	tumorigenesis

STAT5A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/65 super-pathways (see all 65) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_PDGF signaling via STATs and NF-kB

8/11 pathways (see all 11)
Development_PDGF signaling via STATs and NF-kB	1.00	Immune response_IL-10 signaling pathway	0.28
Development PDGF signaling via STATs and NF-kB	1.00	Immune response IL-10 signaling pathway	0.28
Immune response_IL-23 signaling pathway	0.44	IL23-mediated signaling events	0.15
Immune response IL-23 signaling pathway	0.41	Angiopoietin-TIE2 Signaling	0.13

IL-9 Signaling Pathways

8/11 pathways (see all 11)
IL-9 Signaling Pathways	1.00	IL-9 Signaling Pathway	0.42
IL-21 Signaling Pathways	0.90	Immune response_IL-9 signaling pathway	0.42
IL-7 Signaling Pathways	0.90	Immune response IL-9 signaling pathway	0.42
IL-2 Signaling Pathways	0.88	IL-7 Signaling Pathway	0.38

ErbB4 Pathway

Prolactin Signaling	0.54	Thrombopoietin Pathway	0.43
ErbB2-ErbB3 Heterodimers	0.47	Growth Hormone Signaling	0.32
IL-2 Pathway	0.46

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Development_EPO-induced Jak-STAT pathway

	Development_EPO-induced Jak-STAT pathway	1.00			EPO Receptor Signaling	0.42
	Development EPO-induced Jak-STAT pathway	1.00			EPO signaling pathway	0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

5/16 EMD Millipore Pathways for STAT5A (see all 16)

	Immune response IL-9 signaling pathway
	Immune response IL-12 signaling pathway
	Immune response IL-2 activation and signaling pathway
	Development PDGF signaling via STATs and NF-kB
	Immune response IL-22 signaling pathway

5/8 R&D Systems Pathways for STAT5A (see all 8)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-9 Signaling Pathways
	IL-4 Signaling Pathways
	Th1 Differentiation

5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT5A (see all 21)

	FLT3 Signaling
	MAPK Signaling
	PDGF Pathway
	IL-2 Pathway
	Tec Kinases Signaling

1 Cell Signaling Technology (CST) Pathway for STAT5A

Jak/Stat Pathway

5/16 GeneGo (Thomson Reuters) Pathways for STAT5A (see all 16)

	Development Endothelin-1/EDNRA transactivation of EGFR
	Immune response Oncostatin M signaling via JAK-Stat in human cells
	Immune response IL-9 signaling pathway
	Immune response IL-10 signaling pathway
	Immune response IL-2 activation and signaling pathway

5/34 BioSystems Pathways for STAT5A (see all 34)

	ErbB signaling pathway
	AGE/RAGE pathway
	EPO Receptor Signaling
	Adipogenesis
	EGFR1 Signaling Pathway

5/22 Reactome Pathways for STAT5A (see all 22)

	Prolactin receptor signaling
	Signaling by FGFR1 mutants
	Disease
	Downstream signal transduction
	Signal Transduction

1 PharmGKB Pathway for STAT5A

EGFR Inhibitor Pathway, Pharmacodynamics

5/6 Kegg Pathways (Kegg details for STAT5A) (see all 6):

	ErbB signaling pathway
	Jak-STAT signaling pathway
	Measles
	Pathways in cancer
	Chronic myeloid leukemia

STAT5A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STAT5A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/100 Interacting proteins for STAT5A (P42229^{2, 3} ENSP00000341208⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 100)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAP2	Q9UGK3²^,³, ENSP00000317912⁴	MINT-58264 MINT-58265 MINT-58273 MINT-58274 MINT-58254 MINT-58266 MINT-58261 MINT-58267 MINT-58272 MINT-58258 MINT-58257 I2D: score=2 STRING: ENSP00000317912
CRKL	P46109²^,³, ENSP00000346300⁴	MINT-8025839 MINT-8025854 I2D: score=6 STRING: ENSP00000346300
PRTFDC1	Q9NRG1²^,³, ENSP00000318602⁴	MINT-68247 I2D: score=5 STRING: ENSP00000318602
IL2RB	P14784²^,³, ENSP00000216223⁴	MINT-8035160 I2D: score=4 STRING: ENSP00000216223
PTEN	P60484²^,³, ENSP00000361021⁴	MINT-8288542 I2D: score=1 STRING: ENSP00000361021

About this table

Gene Ontology (GO): 5/60 biological process terms (GO ID links to tree view) (see all 60): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000255	allantoin metabolic process	ISS	--
GO:0001553	luteinization	IEA	--
GO:0001779	natural killer cell differentiation	IEA	--
GO:0006101	citrate metabolic process	ISS	--
GO:0006103	2-oxoglutarate metabolic process	ISS	--

STAT5A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

STAT5A for compounds About GeneDecksing

EMD Millipore small molecules for STAT5A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAT5A
10/70 Novoseek chemical compound relationships for STAT5A gene (see all 70) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	83.1	424	11413148 (8), 12764361 (8), 10617656 (6), 8977232 (5) (see all 99)
pkc 412	73.7	3	15178581 (1), 17827387 (1), 15345593 (1)
adaphostin	67.1	2	17252018 (1), 16481037 (1)
imatinib	65	24	12764361 (5), 17533047 (2), 12804638 (2), 15539083 (1) (see all 16)
ag-1296	55	1	11753614 (1)
phosphatidylinositol	54	28	11779872 (3), 11279166 (2), 11756417 (2), 14660677 (1) (see all 21)
gmps	51	1	19179468 (1), 17090651 (1)
phosphotyrosine	47.5	11	8843168 (2), 8943229 (1), 11122381 (1), 12543077 (1) (see all 7)
dasatinib	47.5	13	17431118 (6), 18986703 (1)
ly294002	42.9	9	11756417 (2), 8955182 (1), 11435425 (1)

Search CenterWatch for drugs/clinical trials and news about STAT5A / STA5A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAT5A gene:

NM_003152.3

Unigene Cluster for STAT5A:

Signal transducer and activator of transcription 5A

Hs.437058 [show with all ESTs]

Unigene Representative Sequence: NM_003152

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000345506(uc002hzj.2 uc010cya.2 uc010cyb.2 uc010cyc.2)

ENST00000590949 ENST00000546010 ENST00000590726 ENST00000469124 ENST00000444283

ENST00000588868 ENST00000478897 ENST00000479417 ENST00000468096(uc010cyd.1 uc010cye.1)

ENST00000591556 ENST00000587646 ENST00000452307

miRNA Products:		OriGene 3'-UTR Clone: STAT5A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT5A
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT5A:
		hsa-miR-3163 hsa-miR-466 hsa-miR-520d-5p hsa-miR-548k hsa-miR-524-5p hsa-miR-3941
		SwitchGear 3'UTR luciferase reporter plasmid: STAT5A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT5A (see all 4) OriGene shRNA RFP: STAT5A OriGene siRNA: STAT5A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT5A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT5A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAT5A (NM_003152)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT5A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STAT5A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT5A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT5A

Additional cDNA sequence:

AB208972.1 AK291650.1 AK301457.1 AK310632.1 AK310713.1 BC027036.1 DQ471288.1 L41142.1

U43185.1

11 DOTS entries:

DT.316707 DT.100779483 DT.95079933 DT.100713260 DT.91654479 DT.40106275 DT.100776932 DT.120981769

DT.92440802 DT.100669389 DT.97839095

24/192 AceView cDNA sequences (see all 192):

AI492573 CD676251 CA431848 BM781479 AI090798 AA627581 AA353734 BF772337

BM704538 BQ575850 AW338174 BQ012727 CD742899 CA306440 BU740521 BM760246

BM841493 AI138488 AL602575 CF528761 BM841086 BE272275 BI861645 AI765409

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for STAT5A (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·
SP1:
SP2:																																									-
SP3:									-		-		-						-
SP4:									-										-
SP5:																			-

ExUns:	13b	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20
SP1:							-								-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for STAT5A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAT5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGATTGAG

About this image

STAT5A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Yolk Sac

Definitive Yolk Sac

Definitive Hematopoietic Stem Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STAT5A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAT5A

SOURCE GeneReport for Unigene cluster: Hs.437058

SABiosciences Expression via Pathway-Focused PCR Arrays including STAT5A (see all 11):

Leukemia in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Adipogenesis in human mouse rat

Th17 Response in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STAT5A gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	Q9PWP7_CHICK⁶	signal transducer and activator of transcription 5...	88(a)	1 → many	27(4528273-4536785)
lizard (Anolis carolinensis)	Reptilia	--	--	85(a)	1 → many	6(72644312-72675710)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.17235²	Transcribed sequence with moderate similarity to protein more	81.19(n)		AL896415.2
zebrafish (Danio rerio)	Actinopterygii	stat5.1⁶ stat5.2⁶	signal transducer and activator of transcription 5... signal transducer and activator of transcription 5...	78(a) 74(a)	many ↔ many many ↔ many	3(16895409-16975786) 12(14670401-14756344)
fruit fly (Drosophila melanogaster)	Insecta	Stat92E^{1 , 3}	signal transduction transcription factor³ Signal-transducer and activator of transcription protein more¹	41(a)³ 52.85(n)¹ 45.43(a)¹		3 92F1³ 42428¹ NM_169899.2¹ NP_732516.2¹

ENSEMBL Gene Tree for STAT5A (if available)
TreeFam Gene Tree for STAT5A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAT5A gene

STAT5B² STAT1² STAT4² STAT2² STAT6² STAT3²

6 SIMAP similar genes for STAT5A using alignment to 7 protein entries: STA5A_HUMAN (see all proteins):

STAT5B STAT4 STAT1 STAT2 STAT6 STAT3

STAT5A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187300683^1,2		--	40437575(+)	`TCCCGC/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs144736543^1,2		--	40437693(+)	`CCAAAC/TTTGAC`	1	--	us2k¹		0	--	--	--	--
rs116027674^1,2	C,F,	--	40437951(+)	`CCAGAG/ATGGGG`	1	--	us2k¹		1		WA	118
rs142582094^1,2		--	40438004(+)	`AGGCCA/GAGGCG`	1	--	us2k¹		0	--	--	--	--
rs146024005^1,2		--	40438036(+)	`AGTTCA/GAGACC`	1	--	us2k¹		0	--	--	--	--
rs192148841^1,2		--	40438232(+)	`GGCAAC/TGAGAG`	1	--	us2k¹		0	--	--	--	--
rs28395853^1,2	C,	--	40438526(+)	`AAGACA/GGATGT`	1	--	us2k¹		4		WA	300
rs2948177^1,2	H	--	40438563(-)	`GAGGCC/ATGTTG`	1	--	us2k¹		4		NS EA	418
rs182028426^1,2		--	40438637(+)	`CTCTTA/CAGCAG`	1	--	us2k¹		0	--	--	--	--
rs139989333^1,2		--	40438761(+)	`ACTTCC/TACACC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for STAT5A (40439565 - 40463961 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STAT5A: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for STAT5A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STAT5A for disorders           About GeneDecksing

OMIM gene information: 601511    OMIM disorders: --

20/84 diseases for STAT5A (see all 84):    About MalaCards

interleukin-7 receptor alpha deficiency myeloma estrogen-receptor positive breast cancer spinal muscular atrophy

human t-cell leukemia virus type 2 human t-cell leukemia virus type 1 polycythemia vera aggressive systemic mastocytosis

functioning pituitary adenoma systemic mastocytosis mastocytosis severe congenital neutropenia

juvenile myelomonocytic leukemia mycosis fungoides myeloid leukemia polycythemia

muscular atrophy myelomonocytic leukemia myeloproliferative disorder erythrocytosis

1 disease from the University of Copenhagen DISEASES database for STAT5A:

Breast cancer

10/50 Novoseek disease relationships for STAT5A gene (see all 50) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloproliferative disorders	66.8	7	11030348 (1), 18088232 (1), 7589339 (1), 18694336 (1) (see all 6)
leukemogenesis	63.1	14	10729993 (2), 15652752 (2), 12688363 (1), 17485261 (1) (see all 11)
myeloid leukemia chronic	62.7	8	17503465 (2), 15820062 (1), 8710363 (1), 17431118 (1) (see all 8)
polycythemia vera	61.9	5	7589339 (1), 18694336 (1), 7689483 (1), 17255768 (1) (see all 5)
erythrocytosis, familial	60.1	3	9923445 (2)
leukemia	57.3	28	15652752 (3), 18347089 (2), 17169805 (1), 19363496 (1) (see all 23)
chronic leukemia	39.2	1	20352702 (1)
erythroleukemia	38	2	8861946 (1), 9079629 (1)
thrombocythemia essential	37.9	3	20113333 (2), 17255768 (1)
myeloid leukemia	36.9	6	9606990 (2), 17038539 (2), 10851050 (1), 9240457 (1)

Genetic Association Database (GAD): STAT5A
Human Genome Epidemiology (HuGE) Navigator: STAT5A (16 documents)

Export disorders for STAT5A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STAT5A gene, integrated from 9 sources (see all 962):
(articles sorted by number of sources associating them with STAT5A)

Utopia: connect your pdf to the dynamic
world of online information

Identification and purification of human Stat proteins activated in response to interleukin-2. (PubMed id 7719937)^{1, 2, 3} Hou J.... McKnight S.L. (1995)
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)^{1, 2, 9} Litterst C.M.... Pfitzner E. (2003)
Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)^{1, 2, 9} Martens N....Gertler A. (2005)
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PubMed id 8631883)^{1, 3, 9} Lin J.-X.... Leonard W.J. (1996)
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. (PubMed id 15534001)^{1, 2} Williams C.C....Jones F.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. (PubMed id 7925280)^{1, 9} Gouilleux F....Groner B. (1994)
Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells. (PubMed id 11413148)^{1, 9} Mahajan S....Uckun F.M. (2001)
Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. (PubMed id 8977232)^{1, 9} Chin H....Miura O. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6776	HGNC: 11366	AceView: STAT5A	Ensembl:ENSG00000126561	euGenes: HUgn6776
ECgene: STAT5A	Kegg: 6776	H-InvDB: STAT5A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAT5A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for STAT5A	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/STAT5

Intellectual Property for STAT5A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAT5A gene:
Search GeneIP for patents involving STAT5A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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signal transducer and activator of transcription 5A

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STAT5A Gene

signal transducer and activator of transcription 5A

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