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Aliases for STAT5A Gene

Aliases for STAT5A Gene

  • Signal Transducer And Activator Of Transcription 5A 2 3 5
  • STAT5 3 4
  • MGF 3

External Ids for STAT5A Gene

Previous HGNC Symbols for STAT5A Gene

  • STAT5

Previous GeneCards Identifiers for STAT5A Gene

  • GC17M039918
  • GC17P042595
  • GC17P040348
  • GC17P040812
  • GC17P037694
  • GC17P036204
  • GC17P040439

Summaries for STAT5A Gene

Entrez Gene Summary for STAT5A Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for STAT5A Gene

STAT5A (Signal Transducer And Activator Of Transcription 5A) is a Protein Coding gene. Diseases associated with STAT5A include myeloma and myeloid leukemia. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is STAT2.

UniProtKB/Swiss-Prot for STAT5A Gene

  • Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

Gene Wiki entry for STAT5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT5A Gene

Genomics for STAT5A Gene

Regulatory Elements for STAT5A Gene

Promoters for STAT5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STAT5A on UCSC Golden Path with GeneCards custom track

Genomic Location for STAT5A Gene

Chromosome:
17
Start:
42,287,547 bp from pter
End:
42,311,943 bp from pter
Size:
24,397 bases
Orientation:
Plus strand

Genomic View for STAT5A Gene

Genes around STAT5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT5A Gene

Proteins for STAT5A Gene

  • Protein details for STAT5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42229-STA5A_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 5A
    Protein Accession:
    P42229
    Secondary Accessions:
    • Q1KLZ6

    Protein attributes for STAT5A Gene

    Size:
    794 amino acids
    Molecular mass:
    90647 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.

    Alternative splice isoforms for STAT5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT5A Gene

Proteomics data for STAT5A Gene at MOPED

Post-translational modifications for STAT5A Gene

  • ISGylated.
  • Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway.
  • Ubiquitination at Lys 644, Lys 675, and Lys 689
  • Modification sites at PhosphoSitePlus

Assay Products

  • Cloud-Clone Corp Assay Kits for STAT5A

No data available for DME Specific Peptides for STAT5A Gene

Domains & Families for STAT5A Gene

Gene Families for STAT5A Gene

Graphical View of Domain Structure for InterPro Entry

P42229

UniProtKB/Swiss-Prot:

STA5A_HUMAN :
  • Contains 1 SH2 domain.
  • Belongs to the transcription factor STAT family.
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT5A: view

Function for STAT5A Gene

Molecular function for STAT5A Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription 5A of the GH JAK/STAT pathway,constitutively expressed in peripheral blood lymphocytes,activated by a variety of hormones and cytokines including interleukin 2,interacting with T cell receptor and stimulating T cell proliferation
UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

Gene Ontology (GO) - Molecular Function for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005515 protein binding IPI 12237455
genes like me logo Genes that share ontologies with STAT5A: view
genes like me logo Genes that share phenotypes with STAT5A: view

Animal Models for STAT5A Gene

MGI Knock Outs for STAT5A:

Animal Model Products

Transcription Factor Targets for STAT5A Gene

Selected GeneGlobe predicted Target genes for STAT5A
Targeted motifs for STAT5A Gene
HOMER Transcription Factor Regulatory Elements motif STAT5A
  • Consensus sequence: ATTTCTNAGAAA Submotif: canonical Cell Type: mCD4+ GEO ID: GSE12346

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for STAT5A Gene

Localization for STAT5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT5A Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT5A Gene COMPARTMENTS Subcellular localization image for STAT5A gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with STAT5A: view

Pathways & Interactions for STAT5A Gene

genes like me logo Genes that share pathways with STAT5A: view

SIGNOR curated interactions for STAT5A Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 20489169
GO:0006101 citrate metabolic process ISS --
GO:0006103 2-oxoglutarate metabolic process ISS --
GO:0006105 succinate metabolic process ISS --
GO:0006107 oxaloacetate metabolic process ISS --
genes like me logo Genes that share ontologies with STAT5A: view

Drugs & Compounds for STAT5A Gene

(39) Drugs for STAT5A Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niclosamide Approved Pharma 6
SH-4-54 Pharma 0

(33) Additional Compounds for STAT5A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STAT5A: view

Transcripts for STAT5A Gene

Unigene Clusters for STAT5A Gene

Signal transducer and activator of transcription 5A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAT5A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1:
SP2: -
SP3: - - - -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: - - -
SP9:
SP10: -
SP11:
SP12: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STAT5A Gene

GeneLoc Exon Structure for
STAT5A
ECgene alternative splicing isoforms for
STAT5A

Expression for STAT5A Gene

mRNA expression in normal human tissues for STAT5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT5A Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for STAT5A Gene

This gene is overexpressed in Lymph node (15.6), Peripheral blood mononuclear cells (15.3), and Tlymphocyte (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAT5A Gene



SOURCE GeneReport for Unigene cluster for STAT5A Gene Hs.437058

genes like me logo Genes that share expression patterns with STAT5A: view

Protein tissue co-expression partners for STAT5A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAT5A Gene

Orthologs for STAT5A Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAT5A 36
  • 100 (a)
OneToOne
STAT5A 35
  • 99.54 (n)
  • 99.87 (a)
cow
(Bos Taurus)
Mammalia STAT5A 35
  • 91.65 (n)
  • 96.6 (a)
STAT5A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAT5A 35
  • 91.86 (n)
  • 96.85 (a)
STAT5A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stat5a 16
Stat5a 35
  • 90.54 (n)
  • 96.47 (a)
Stat5a 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAT5A 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Stat5a 35
  • 90.37 (n)
  • 95.96 (a)
chicken
(Gallus gallus)
Aves STAT5 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17235 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11837 35
zebrafish
(Danio rerio)
Actinopterygii stat5.1 36
  • 78 (a)
ManyToMany
stat5.2 36
  • 74 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta STAT2 35
  • 53.55 (n)
  • 41.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 37
  • 41 (a)
Stat92E 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 37
  • 28 (a)
sta-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3791 36
  • 50 (a)
OneToMany
Species with no ortholog for STAT5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT5A Gene

ENSEMBL:
Gene Tree for STAT5A (if available)
TreeFam:
Gene Tree for STAT5A (if available)

Paralogs for STAT5A Gene

Paralogs for STAT5A Gene

(6) SIMAP similar genes for STAT5A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with STAT5A: view

Variants for STAT5A Gene

Sequence variations from dbSNP and Humsavar for STAT5A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2230134 - 42,301,451(+) CACCC(A/G/T)CAAGT reference, missense
rs2230124 -- 42,306,423(+) CTGTC(C/T)GTGTC reference, synonymous-codon
rs2230135 -- 42,310,522(+) GTACT(C/T)GATCA reference, synonymous-codon, missense
rs2067694 -- 42,310,513(+) CCTGA(C/T)CATGT reference, synonymous-codon, missense
rs2948177 -- 42,286,545(-) GAGGC(A/C)TGTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STAT5A Gene

Variant ID Type Subtype PubMed ID
nsv908248 CNV Loss 21882294
nsv833449 CNV Loss 17160897

Variation tolerance for STAT5A Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 50.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAT5A Gene

HapMap Linkage Disequilibrium report
STAT5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT5A Gene

Disorders for STAT5A Gene

MalaCards: The human disease database

(15) MalaCards diseases for STAT5A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloma
  • multiple myeloma
myeloid leukemia
  • leukemia myelogenous
polycythemia vera, somatic
  • primary polycythemia
leukemia, chronic myeloid, somatic
  • chronic myeloid leukemia
myelofibrosis
  • agnogenic myeloid metaplasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STAT5A

Genetic Association Database (GAD)
STAT5A
Human Genome Epidemiology (HuGE) Navigator
STAT5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAT5A
genes like me logo Genes that share disorders with STAT5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAT5A Gene

Publications for STAT5A Gene

  1. Identification and purification of human Stat proteins activated in response to interleukin-2. (PMID: 7719937) Hou J. … McKnight S.L. (Immunity 1995) 2 3 4 67
  2. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PMID: 8631883) Lin J.-X. … Leonard W.J. (J. Biol. Chem. 1996) 2 3 23
  3. Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. (PMID: 20415542) Sobti R.C. … Das B.C. (J. Recept. Signal Transduct. Res. 2010) 3 23
  4. Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation. (PMID: 19923221) Ross J.A. … Kirken R.A. (J. Biol. Chem. 2010) 3 23
  5. Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. (PMID: 20124477) Tran T.H. … Rui H. (Cancer Res. 2010) 3 23

Products for STAT5A Gene

Sources for STAT5A Gene

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