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STAT5A Gene

protein-coding   GIFtS: 72
GCID: GC17P040439

Signal Transducer And Activator Of Transcription 5A


(Previous symbol: STAT5)
  See STAT5A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducer And Activator Of Transcription 5A1 2
STAT51 2 3
MGF2

External Ids:    HGNC: 113661   Entrez Gene: 67762   Ensembl: ENSG000001265617   OMIM: 6015115   UniProtKB: P422293   

Export aliases for STAT5A gene to outside databases

Previous GC identifers: GC17M039918 GC17P042595 GC17P040348 GC17P040812 GC17P037694 GC17P036204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAT5A Gene:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines
and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form
homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This
protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF,
erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma
associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for
tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which
suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
found for this gene. (provided by RefSeq, Dec 2013)

GeneCards Summary for STAT5A Gene:
STAT5A (signal transducer and activator of transcription 5A) is a protein-coding gene. Diseases associated with STAT5A include aggressive systemic mastocytosis, and human t-cell leukemia virus type 2. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229
Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular
responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate
cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced
transcription. Regulates the expression of milk proteins during lactation

Gene Wiki entry for STAT5A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAT5A gene promoter:
         GR   c-Fos   NF-1   NF-1/L   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STAT5A promoter sequence
   Search Chromatin IP Primers for STAT5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q11.2

STAT5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT5A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040439:  view genomic region     (about GC identifiers)

Start:
40,439,565 bp from pter      End:
40,463,961 bp from pter
Size:
24,397 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 5A  
Size: 794 amino acids; 90647 Da
Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts
with NCOA1 and SOCS7. Interacts with ERBB4
Secondary accessions: Q1KLZ6
Alternative splicing: 2 isoforms:  P42229-1   P42229-2   

Explore the universe of human proteins at neXtProt for STAT5A: NX_P42229

Explore proteomics data for STAT5A at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO.
    Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine
    phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is
    required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal
    transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3;
    wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively,
    can be phosphorylated by JAK2 at Tyr-694. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates
    prolactin signaling pathway1
  • ISGylated (By similarity)1
  • Ubiquitination2 at Lys527, Lys644, Lys675, Lys689
  • Modification sites at PhosphoSitePlus

  • See STAT5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001275647.1  NP_001275648.1  NP_001275649.1  NP_003143.2  

    ENSEMBL proteins: 
     ENSP00000341208   ENSP00000468749   ENSP00000443107   ENSP00000464730   ENSP00000407327  
     ENSP00000465437   ENSP00000466320   ENSP00000400320  
    Reactome Protein details: P42229

    STAT5A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAT5A
    OriGene Protein Over-expression Lysate for STAT5A
    OriGene MassSpec for STAT5A
    OriGene Custom Protein Services for STAT5A
    GenScript Custom Purified and Recombinant Proteins Services for STAT5A
    Novus Biologicals STAT5A Proteins
    Novus Biologicals STAT5A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT5A

     
    Search eBioscience for Proteins for STAT5A 

    STAT5A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT5A
    R&D Systems Antibodies for STAT5A
    Cell Signaling Technology (CST) Antibodies for STAT5A 
    OriGene Antibodies for STAT5A
    OriGene Custom Antibody Services for STAT5A
    Novus Biologicals STAT5A Antibodies
    Abcam antibodies for STAT5A (P51692, P42229)
    Cloud-Clone Corp. Antibodies for STAT5A
    ThermoFisher Antibody for STAT5A
    LSBio Antibodies in human, mouse, rat for STAT5A

    STAT5A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAT5A
    R&D Systems ELISAs for STAT5A         (see all)
    GenScript Custom Assay Services for STAT5A
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT5A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT5A
    Cloud-Clone Corp. CLIAs for STAT5A
    Search eBioscience for ELISAs for STAT5A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 9):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-dom_pair
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P42229

    ProtoNet protein and cluster: P42229

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with STAT5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STA5A_HUMAN, P42229
    Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular
    responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate
    cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced
    transcription. Regulates the expression of milk proteins during lactation

         Genatlas biochemistry entry for STAT5A:
    signal transducer and activator of transcription 5A of the GH JAK/STAT pathway,constitutively expressed in
    peripheral blood lymphocytes,activated by a variety of hormones and cytokines including interleukin 2,interacting
    with T cell receptor and stimulating T cell proliferation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with STAT5A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for STAT5A:
     Decreased Wnt reporter activit  Upregulation of Wnt/beta-caten 

         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Stat5a):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  normal  reproductive system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with STAT5A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for STAT5A: Stat5atm1Mam Stat5a/Stat5bStat5a/tm2.1Mam Stat5atm1Jni

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAT5A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAT5A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT5A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT5A

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATTTCTNAGAAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT5A:
    hsa-mir-124-3p (MIRT023082), hsa-mir-222-3p (MIRT000018)

    Block miRNA regulation of human, mouse, rat STAT5A using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate STAT5A:
    hsa-miR-3163 hsa-miR-466 hsa-miR-520d-5p hsa-miR-548k hsa-miR-524-5p hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidSTAT5A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAT5A
    Predesigned siRNA for gene silencing in human, mouse, rat STAT5A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT5A

    Clone
    Products:
         
    OriGene clones in human, mouse for STAT5A (see all 7)
    OriGene ORF clones in mouse, rat for STAT5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAT5A (NM_003152)
    Sino Biological Human cDNA Clone for STAT5A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT5A
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAT5A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STA5A_HUMAN, P42229: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with STAT5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAT5A About   (see all 68)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    IL-2 Signaling Pathways0.88
    IL-7 Signaling Pathway0.40
    2Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    Development PDGF signaling via STATs and NF kB0.41
    Angiopoietin-TIE2 Signaling0.36
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Immune response IL 10 signaling pathway0.38
    3ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    4Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    EPO Receptor Signaling0.42
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Prolactin Signaling Pathway0.39


    Find genes that share SuperPaths with STAT5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for STAT5A (see all 8)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-9 Signaling Pathways
    IL-4 Signaling Pathways
    Th1 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STAT5A (see all 21)
        FLT3 Signaling
    MAPK Signaling
    PDGF Pathway
    IL-2 Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for STAT5A
        Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for STAT5A (see all 16)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway
    Immune response IL-10 signaling pathway
    Immune response IL-2 activation and signaling pathway

    Selected BioSystems Pathways for STAT5A (see all 35)
        EGFR1 Signaling Pathway
    Adipogenesis
    ErbB signaling pathway
    EPO Receptor Signaling
    AGE/RAGE pathway


    Selected Reactome Pathways for STAT5A (see all 10)
        Prolactin receptor signaling
    Interleukin-7 signaling
    Downstream signal transduction
    Interleukin-2 signaling
    Interleukin-3, 5 and GM-CSF signaling

    1 PharmGKB Pathway for STAT5A
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for STAT5A) (see all 10):
        ErbB signaling pathway
    Jak-STAT signaling pathway
    Prolactin signaling pathway
    Hepatitis B
    Measles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT5A (see all 11): 
              Leukemia in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Adipogenesis in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAT5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAT5A (P422291, 2, 3 ENSP000003412084) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAP2Q9UGK32, 3MINT-58264 MINT-58265 MINT-58273 MINT-58274 MINT-58254 MINT-58266 MINT-58261 MINT-58267 MINT-58272 MINT-58258 MINT-58257 I2D: score=2 
    CRKLP461092, 3, ENSP000003463004MINT-8025839 MINT-8025854 I2D: score=6 STRING: ENSP00000346300
    PRTFDC1Q9NRG12, 3, ENSP000003186024MINT-68247 I2D: score=5 STRING: ENSP00000318602
    IL2RBP147842, 3, ENSP000002162234MINT-8035160 I2D: score=4 STRING: ENSP00000216223
    PTENP604842, 3, ENSP000003610214MINT-8288542 I2D: score=1 STRING: ENSP00000361021
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000255allantoin metabolic process ISS--
    GO:0001553luteinization IEA--
    GO:0001779natural killer cell differentiation IEA--
    GO:0006101citrate metabolic process ISS--
    GO:00061032-oxoglutarate metabolic process ISS--

    Find genes that share ontologies with STAT5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAT5A (STA5A)

    Selected Novoseek inferred chemical compound relationships for STAT5A gene (see all 70)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.1 424 11413148 (8), 12764361 (8), 10617656 (6), 8977232 (5) (see all 99)
    pkc 412 73.7 3 15178581 (1), 17827387 (1), 15345593 (1)
    adaphostin 67.1 2 17252018 (1), 16481037 (1)
    imatinib 65 24 12764361 (5), 17533047 (2), 12804638 (2), 15539083 (1) (see all 16)
    ag-1296 55 1 11753614 (1)
    phosphatidylinositol 54 28 11779872 (3), 11279166 (2), 11756417 (2), 14660677 (1) (see all 21)
    gmps 51 1 19179468 (1), 17090651 (1)
    phosphotyrosine 47.5 11 8843168 (2), 8943229 (1), 11122381 (1), 12543077 (1) (see all 7)
    dasatinib 47.5 13 17431118 (6), 18986703 (1)
    ly294002 42.9 9 11756417 (2), 8955182 (1), 11435425 (1)



    Find genes that share compounds with STAT5A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAT5A gene (4 alternative transcripts): 
    NM_001288718.1  NM_001288719.1  NM_001288720.1  NM_003152.3  

    Unigene Cluster for STAT5A:

    Signal transducer and activator of transcription 5A
    Hs.437058  [show with all ESTs]
    Unigene Representative Sequence: NM_003152
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345506(uc002hzj.2 uc010cya.2 uc010cyb.2 uc010cyc.2)
    ENST00000590949 ENST00000546010 ENST00000590726 ENST00000469124 ENST00000444283
    ENST00000588868 ENST00000478897 ENST00000479417 ENST00000468096(uc010cyd.1 uc010cye.1)
    ENST00000591556 ENST00000587646 ENST00000452307
    miRNA
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    Block miRNA regulation of human, mouse, rat STAT5A using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate STAT5A:
    hsa-miR-3163 hsa-miR-466 hsa-miR-520d-5p hsa-miR-548k hsa-miR-524-5p hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidSTAT5A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAT5A
    Predesigned siRNA for gene silencing in human, mouse, rat STAT5A
    Clone
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    OriGene clones in human, mouse for STAT5A (see all 7)
    OriGene ORF clones in mouse, rat for STAT5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAT5A (NM_003152)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT5A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAT5A
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT5A
      QuantiTect SYBR Green Assays in human, mouse, rat STAT5A
      QuantiFast Probe-based Assays in human, mouse, rat STAT5A

    Additional mRNA sequence: 

    AB208972.1 AK291650.1 AK301457.1 AK310632.1 AK310713.1 BC027036.1 DQ471288.1 L41142.1 
    U43185.1 

    11 DOTS entries:

    DT.316707  DT.100779483  DT.95079933  DT.100713260  DT.91654479  DT.40106275  DT.100776932  DT.120981769 
    DT.92440802  DT.100669389  DT.97839095 

    Selected AceView cDNA sequences (see all 192):

    AI138488 BF001604 BM683593 BF056492 CB306548 AW338174 AA353734 BM760246 
    AI765409 AA430676 AA627581 CA306440 CD676251 BM841086 BM704538 CA422369 
    BX431739 AI189521 BQ772831 AI492573 BM841493 BQ012727 CF528761 BM781479 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAT5A (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                          -                                 
    SP3:                          -     -     -                 -                                                                                                   
    SP4:                          -                             -                                                                                                   
    SP5:                                                        -                                                                                                   

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
    SP1:                    -                       -               
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for STAT5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAT5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGATTGAG
    STAT5A Expression
    About this image


    STAT5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Erythroblasts Hematopoietic Bone Marrow
     
     Adipose (Muscoskeletal System)
             Subcutaneous White Preadipocytes Body Subcutaneous White Adipose
     
     Thymus (Hematopoietic System)
             Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    STAT5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAT5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437058
        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT5A (see all 11): 
              Leukemia in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Adipogenesis in human mouse rat
              Th17 Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STAT5A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat5a1 , 5 signal transducer and activator of transcription 5A1, 5 90.54(n)1
    96.47(a)1
      11 (63.77 cM)5
    208501  NM_011488.31  NP_035618.11 
     1008593515 
    chicken
    (Gallus gallus)
    Aves STAT56
    Gallus gallus signal transducer and activator of t...
    88(a)
    1 → many
    27(4875164-4886606)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    86(a)
    1 → many
    6(72573138-72675710)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172352 Transcribed sequence with moderate similarity to protein more 81.19(n)    AL896415.2 
    zebrafish
    (Danio rerio)
    Actinopterygii stat5.16
    stat5.26
    signal transducer and activator of transcription 5...
    signal transducer and activator of transcription 5...
    78(a)
    74(a)
    many ↔ many
    many ↔ many
    3(16895409-16975786) ENSDARG00000019392
    12(14670401-14756388) ENSDARG00000055588
    fruit fly
    (Drosophila melanogaster)
    Insecta Stat92E3 signal transduction transcription
    factor
    41(a)   3 92F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H4A.173   -- 28(a)   IV(16664481-16671418)   --


    ENSEMBL Gene Tree for STAT5A (if available)
    TreeFam Gene Tree for STAT5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAT5A gene
    STAT5B2  STAT12  STAT42  STAT22  STAT32  STAT62  
    6 SIMAP similar genes for STAT5A using alignment to 6 protein entries:     STA5A_HUMAN (see all proteins):
    STAT5B    STAT4    STAT1    STAT2    STAT6    STAT3

    Find genes that share paralogs with STAT5A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAT5A (see all 607)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387986931,2
    --36202278(+) TCCCAC/TCTCAG 1 -- us2k10--------
    rs1816045541,2
    --36202443(+) GGACCA/GCAGCT 1 -- us2k10--------
    rs1493639681,2
    --36202483(+) CCTGAA/GCCCCC 1 -- us2k10--------
    rs1873006831,2
    --40437575(+) TCCCGC/TGGCCT 1 -- us2k10--------
    rs1447365431,2
    --40437693(+) CCAAAC/TTTGAC 1 -- us2k10--------
    rs1160276741,2
    C,F--40437951(+) CCAGAG/ATGGGG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1425820941,2
    --40438004(+) AGGCCA/GAGGCG 1 -- us2k10--------
    rs1460240051,2
    --40438036(+) AGTTCA/GAGACC 1 -- us2k10--------
    rs1921488411,2
    --40438232(+) GGCAAC/TGAGAG 1 -- us2k10--------
    rs283958531,2
    C,F--40438526(+) AAGACA/GGATGT 1 -- us2k14Minor allele frequency- G:0.03WA 300

    HapMap Linkage Disequilibrium report for STAT5A (40439565 - 40463961 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STAT5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908248CNV Loss21882294
    nsv833449CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT5A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601511    OMIM disorders: --

    6 diseases for STAT5A:    
    About MalaCards
    aggressive systemic mastocytosis    human t-cell leukemia virus type 2    myeloma    polycythemia vera
    chronic myeloid leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for STAT5A:
    Breast cancer

    Find genes that share disorders with STAT5A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for STAT5A gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloproliferative disorders 66.8 7 11030348 (1), 18088232 (1), 7589339 (1), 18694336 (1) (see all 6)
    leukemogenesis 63.1 14 10729993 (2), 15652752 (2), 12688363 (1), 17485261 (1) (see all 11)
    myeloid leukemia chronic 62.7 8 17503465 (2), 15820062 (1), 8710363 (1), 17431118 (1) (see all 8)
    polycythemia vera 61.9 5 7589339 (1), 18694336 (1), 7689483 (1), 17255768 (1) (see all 5)
    erythrocytosis, familial 60.1 3 9923445 (2)
    leukemia 57.3 28 15652752 (3), 18347089 (2), 17169805 (1), 19363496 (1) (see all 23)
    chronic leukemia 39.2 1 20352702 (1)
    erythroleukemia 38 2 8861946 (1), 9079629 (1)
    thrombocythemia essential 37.9 3 20113333 (2), 17255768 (1)
    myeloid leukemia 36.9 6 9606990 (2), 17038539 (2), 10851050 (1), 9240457 (1)

    Genetic Association Database (GAD): STAT5A
    Human Genome Epidemiology (HuGE) Navigator: STAT5A (16 documents)

    Export disorders for STAT5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAT5A gene, integrated from 10 sources (see all 991):
    (articles sorted by number of sources associating them with STAT5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and purification of human Stat proteins activated in response to interleukin-2. (PubMed id 7719937)1, 2, 3 Hou J.... McKnight S.L. (Immunity 1995)
    2. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)1, 2, 9 Litterst C.M.... Pfitzner E. (J. Biol. Chem. 2003)
    3. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1, 2, 9 Martens N....Gertler A. (J. Biol. Chem. 2005)
    4. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon I+. (PubMed id 20065083)1, 4, 9 Kreil S....Cross N.C. (Haematologica 2010)
    5. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. (PubMed id 17639043)1, 4, 9 Vaclavicek A....FAPrsti A. (Endocr. Relat. Cancer 2007)
    6. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PubMed id 8631883)1, 3, 9 Lin J.-X.... Leonard W.J. (J. Biol. Chem. 1996)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    9. Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients. (PubMed id 20530519)1, 4 Yu H.H....Chiang B.L. (Lupus 2010)
    10. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6776 HGNC: 11366 AceView: STAT5A Ensembl:ENSG00000126561 euGenes: HUgn6776
    ECgene: STAT5A Kegg: 6776 H-InvDB: STAT5A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STAT5A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT5A Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/STAT5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAT5A gene:
    Search GeneIP for patents involving STAT5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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