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STAT5A Gene

protein-coding GIFtS: 71

GC17P037694

signal transducer and activator of transcription 5A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: STAT5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGF ^¹, ²
STAT5 ^², ³

Descriptions
signal transducer and activator of transcription 5A ^²

External Ids
HGNC: 11366¹
Entrez Gene: 6776²
UniProtKB: P42229³
Ensembl: ENSG00000126561⁷

Search outside databases for aliases for STAT5A gene

Previous GC identifers: GC17M039918 GC17P042595 GC17P040348 GC17P040812

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for STAT5A:

The protein encoded by this gene is a member of the STAT family of transcription factors. In

response to cytokines and growth factors, STAT family members are phosphorylated by the receptor

associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where

they act as transcription activators. This protein is activated by, and mediates the responses of

many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different

growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2

gene fusion is independent of cell stimulus and has been shown to be essential for the

tumorigenesis. The mouse counterpart of this gene is found to induce the expression of

BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by

RefSeq]

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229

Function: Carries out a dual function: signal transduction and activation of transcription. Binds

to the GAS element and activates PRL-induced transcription

Gene Wiki entry for STAT5A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the STAT5A gene

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q11.2

STAT5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P037694: (about GC identifiers)

Start:	37,693,091 bp from pter
End:	37,717,484 bp from pter
Size:	24,394 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229 (See protein sequence)

Recommended Name: Signal transducer and activator of transcription 5A

Size: 794 amino acids; 90647 Da

Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By

similarity). Interacts with NCOA1 and SOCS7

Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to

phosphorylation

Post-translational modifications:

Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin,

erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity

and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By

similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003143.2

ENSEMBL proteins:

ENSP00000341208

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (STAT 5A + B, STAT5a, STAT5)
	Human Recombinant Proteins from Abnova (STAT5A)

OriGene Purified Recombinant Human Protein: STAT5A

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for STAT5A:

	Invitrogen Antibodies for STAT5A
	Millipore Mono- and Polyclonal Antibodies for the study of STAT5A
	Sigma-Aldrich Antibodies for STAT5A
	R&D Systems Antibodies for STAT5A
	Cell Signaling Technology (CST) Antibodies for STAT5A (Stat5 alpha)
	Antibodies from Abcam (STAT 5A + B, STAT5a, STAT5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (STAT5A)
	Novus Biologicals Antibodies for STAT5A

Assays for STAT5A:

	Invitrogen Assays for STAT5A
	Millipore Kits and Assays for the Analysis of STAT5A
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT5A (Stat5 alpha)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P42229

ProtoNet protein and cluster: P42229

1 Blocks protein family: IPB001217 STAT protein

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229

Similarity: Belongs to the transcription factor STAT family

Similarity: Contains 1 SH2 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (STAT5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (STAT5A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003152

Applied Biosystems Silencer® siRNAs for STAT5A

Sigma-Aldrich siRNA for STAT5A

Sigma-Aldrich shRNA Panels and shRNA for STAT5A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for STAT5A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003152
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003152
untagged cDNA clone in CMV expression vector: NM_003152

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003152

UniProtKB/Swiss-Prot: STA5A_HUMAN, P42229

Function: Carries out a dual function: signal transduction and activation of transcription. Binds

to the GAS element and activates PRL-induced transcription

Genatlas biochemistry entry for STAT5A:

signal transducer and activator of transcription 5A of the GH JAK/STAT pathway,constitutively

expressed in peripheral blood lymphocytes,activated by a variety of hormones and cytokines

including interleukin 2,interacting with T cell receptor and stimulating T cell proliferation

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Stat5a):

adipose tissue	endocrine/exocrine gland	growth/size	hematopoietic system	immune system
lethality-prenatal/perinatal	liver/biliary system	normal	reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	7719937 8631883
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	16819511
GO:0042301	phosphate binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/21 Sigma-Aldrich "Your Favorite Gene" Pathways for STAT5A (Your Favorite Gene powered by Ingenuity) (see all 21 )

PPAR Signaling
JAK/Stat Signaling
IL-3 Signaling
Acute Myeloid Leukemia Signaling
TREM1 Signaling

GeneDecks STAT5A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for STAT5A

5/142 Interacting proteins for STAT5A (P42229^{1, 2} ENSP00000341208³) via UniProtKB, MINT, and/or STRING (see all 142 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR1	P03372², ENSP00000206249³	MINT-50647 MINT-50646 STRING (score=.983)
PTPN1	P18031², ENSP00000360683³	MINT-6793989 MINT-6793891 STRING (score=.976)
NMI	Q13287¹	EBI-749537, EBI-372942
STAP2	Q9UGK3²	MINT-58264 MINT-58265 MINT-58273 MINT-58274 MINT-58254 MINT-58266 MINT-58261 MINT-58267 MINT-58272 MINT-58258 MINT-58257
MAGEA12	P43365²	MINT-67540

About this table

5/42 Gene Ontology (GO) biological process terms (links to tree view) (see all 42 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000255	allantoin metabolic process	ISS	--
GO:0001553	luteinization	IEA	--
GO:0001779	natural killer cell differentiation	IEA	--
GO:0006101	citrate metabolic process	ISS	--
GO:0006103	2-oxoglutarate metabolic process	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for STAT5A

Browse Small Molecules at Sigma-Aldrich

Compounds for STAT5A available from Tocris Bioscience
10/37 Novoseek chemical compound relationships for STAT5A gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	83.50	416	11413148 (8), 12764361 (8), 10617656 (6), 8977232 (5) (see all 99)
adaphostin	69.35	2	17252018 (1), 16481037 (1)
ag-1296	56.39	1	11753614 (1)
phosphatidylinositol	54.82	28	11779872 (3), 11279166 (2), 11756417 (2), 14660677 (1) (see all 21)
gmps	53.84	1	19179468 (1), 17090651 (1)
phosphotyrosine	45.12	11	8843168 (2), 8943229 (1), 11122381 (1), 12543077 (1) (see all 7)
pd 98,059	43.35	7	9804779 (2), 8943229 (1), 11796503 (1)
gp 130	40.98	6	8843168 (3), 10858439 (1), 11152572 (1), 11481050 (1)
phenylalanine	25.52	3	10372132 (1), 9516478 (1), 9447970 (1)
wortmannin	24.35	5	8955182 (1), 9694701 (1), 9804779 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (STAT5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (STAT5A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003152

Sigma-Aldrich siRNA for STAT5A

Sigma-Aldrich shRNA Panels and shRNA for STAT5A

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for STAT5A gene:

NM_003152.3

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003152
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003152
                                 untagged cDNA clone in CMV expression vector: NM_003152

Additional cDNA sequence:

AB208972.1 AK291650.1 AK301457.1 AK310632.1 AK310713.1 BC027036.1 CR597393.1 DQ471288.1

L41142.1 U43185.1

11 DOTS entries:

DT.316707 DT.100779483 DT.95079933 DT.100713260 DT.91654479 DT.40106275 DT.100669389 DT.100776932

DT.120981769 DT.92440802 DT.97839095

24/192 AceView cDNA sequences (see all 192 ):

BM700541 BF056492 AA595053 BQ012727 BI861645 CA422369 AI376005 CA431848

CR597393 BM683593 BM781479 AI244210 AI189521 BM760246 BE272275 AI866398

AW293703 CF528761 BM841086 AW338174 AL602575 BM704538 AI765409 BQ893695

highest scoring ESTs for STAT5A:

U43185 AA130179 AA227215 AA346384 AA353734 AA430676 AA595053 AI201471 AI572105 AI834335

Unigene Cluster for STAT5A:

Signal transducer and activator of transcription 5A

Hs.437058 [show with all ESTs]

Unigene Representative Sequence: NM_003152

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for STAT5A (see all 12 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·
SP1:
SP2:																																									-
SP3:									-		-		-						-
SP4:									-										-
SP5:																			-

ExUns:	13b	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20
SP1:							-								-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for STAT5A

1 Ensembl transcript including schematic representation:

ENST00000345506

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

STAT5A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for STAT5A

¹ / ² / ³

5 probe-sets matching STAT5A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75183_at²^{, 3}	U95-D	1	1.00	1.00	0.97	1.08	AI990633	0.80	1.00	0.91	1
506_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.07	U43185	1.00	1.00	1.00	1
40458_at²^{, 3}	U95-A	1	0.62	1.00	0.87	0.87	U43185	1.00	1.00	1.00	1
203010_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003152	0.60	1.00	0.82	1
203010_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks STAT5A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGATTGAG

SOURCE GeneReport for Unigene cluster: Hs.437058
Expression variation in blood from EXPOLDB for STAT5A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for STAT5A gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	STAT5A¹	--	signal transducer and activator of transcription 5A	91.86(n) 96.85(a)	490968 XM_854813.1 XP_859906.1
chimpanzee (Pan troglodytes)	STAT5A¹	--	signal transducer and activator of transcription 5A	99.54(n) 99.87(a)	454681 XM_001165870.1 XP_001165870.1
cow (Bos taurus)	STAT5A¹	--	signal transducer and activator of transcription 5A	91.65(n) 96.6(a)	282375 NM_001012673.1 NP_001012691.1
rat (Rattus norvegicus)	Stat5a¹	--	signal transducer and activator of transcription 5A	90.37(n) 95.96(a)	24918 NM_017064.1 NP_058760.1
mouse (Mus musculus)	Stat5a^{1, 5}	11 (60.50 cM)⁵	signal transducer and activator of transcription 5A^{1, 5}	90.54(n)¹ 96.47(a)¹	20850¹ NM_011488.2¹ NP_035618.1¹ AA959963⁵ AF049104⁵ (see all 20)

About this table Species with no ortholog for STAT5A

ENSEMBL Gene Tree for STAT5A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for STAT5A gene

STAT5B² STAT6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/138 NCBI SNPs in STAT5A are shown (see all 138 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3198502^1,2	A,C,F,O	37716520(+)	`TCCTGG/TGCCCC`	1	--	ut3¹ ese³		4	MN NA	316
	rs994607^1,2	C,H	37692535(+)	`GCTCAG/TAGTGG`	1	--	ng5¹		7	EA NA EU WA	472
--	rs2230123^1,2	F	37705370(+)	`GCAGGT/CGTCTC`	1	A/V	mis¹ ese³		2	MN	92
	rs2948177^1,2	H	37692089(-)	`GAGGCC/ATGTTG`	1	--	ng5¹		4	EU EA WA	418
	rs28395853^1,2	F	37692052(+)	`AAGACA/GGATGT`	1	--	ng5¹		1	--	90
--	rs2230134^1,2	F	37706995(+)	`CACCCG/ACAACG`	1	H/R	mis¹		1	MN	64
	rs1135669^1,2	C,F,O	37713263(+)	`TTTGAC/TTCCCG`	1	D/D	syn¹		5	EA NA	1690
	rs2067694^1,2	C,H	37716057(+)	`CCTGAC/TCATGT`	1	D/D	syn¹ ese³		5	EU EA WA	510
--	rs2230124^1,2	F	37711967(+)	`CTGTCC/TGTGTC`	1	S/S	syn¹ ese³		2	MN	100
--	rs2230125^1,2	F	37713041(+)	`GATGGG/TGCCAT`	1	G/G	syn¹		2	MN	102

About this table

HapMap Linkage Disequilibrium images for STAT5A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601511

10/46 Novoseek disease relationships for STAT5A gene (see all 46 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloproliferative disorders	66.79	6	11030348 (1), 18088232 (1), 7589339 (1), 18694336 (1) (see all 5)
leukemogenesis	64.46	14	10729993 (2), 15652752 (2), 12688363 (1), 17485261 (1) (see all 11)
myeloid leukemia chronic	63.62	8	17503465 (2), 15820062 (1), 8710363 (1), 17431118 (1) (see all 8)
erythrocytosis, familial	61.24	3	9923445 (2)
polycythemia vera	57.99	4	7589339 (1), 18694336 (1), 7689483 (1), 17255768 (1)
leukemia	57.60	25	15652752 (3), 18347089 (2), 17169805 (1), 19363496 (1) (see all 21)
myeloid leukemia	38.43	6	9606990 (2), 17038539 (2), 10851050 (1), 9240457 (1)
idiopathic myelofibrosis	36.88	3	12842707 (1), 7589339 (1), 17255768 (1)
erythroleukemia	35.71	2	8861946 (1), 9079629 (1)
leukemia myelomonocytic chronic	33.58	1	7514248 (1)

About this table

Genetic Association Database: STAT5A
Human Genome Epidemiology Navigator: STAT5A (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/828 PubMed articles for STAT5A gene (see all 828 ):

Identification and purification of human Stat proteins activated in response to interleukin-2. (PubMed id 7719937)^{2, 3, 4} Hou J.... McKnight S.L. (1995)
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PubMed id 12954634)^{1, 3, 4} Litterst C.M.... Pfitzner E. (2003)
Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)^{1, 3, 4} Martens N....Gertler A. (2005)
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PubMed id 8631883)^{1, 2, 3} Lin J.X....Leonard W.J. (1996)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{3, 6} Saito T....Kawata S. (2004)
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. (PubMed id 7925280)^{1, 3} Gouilleux F....Groner B. (1994)
Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells. (PubMed id 11413148)^{1, 3} Mahajan S....Uckun F.M. (2001)
Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. (PubMed id 8977232)^{1, 3} Chin H....Miura O. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6776	HGNC: 11366	AceView: STAT5A	Ensembl:ENSG00000126561	euGenes: HUgn6776
ECgene: STAT5A	H-InvDB: STAT5A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for STAT5A	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/STAT5

Licensable Technologies for STAT5A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for STAT5A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for STAT5A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for STAT5A		Antibodies for STAT5A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for STAT5A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (STAT5A)
	Antibodies (STAT5A)
	Chimera RNAi (STAT5A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for STAT5A (Stat5 alpha)

	Recombinant Proteins (STAT 5A + B, STAT5a, STAT5)
	Antibodies (STAT 5A + B, STAT5a, STAT5)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for STAT5A

	Drugs for STAT5A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for STAT5A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
STAT5A Gene at Home site.
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STAT5A Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for STAT5A

Summaries
for STAT5A

Genomic Location
for STAT5A

Proteins
for STAT5A

Protein Domains/
Families
for STAT5A

Gene Function
for STAT5A

Pathways & Interactions
for STAT5A

Drugs & Compounds
for STAT5A

Transcripts
for STAT5A

Expression
for STAT5A

Orthologs
for STAT5A

Paralogs
for STAT5A

SNPs/Variants
for STAT5A

Disorders & Mutations
for STAT5A

Medical News
for STAT5A

Publications
for STAT5A

Search for STAT5A

Genome Databases showing STAT5A

Other Databases showing STAT5A

Specialized Databases showing STAT5A

Licensable Technologies
for STAT5A

Services
for STAT5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

STAT5A Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor STAT5A

Summariesfor STAT5A

Genomic Locationfor STAT5A

Proteinsfor STAT5A

Protein Domains/Familiesfor STAT5A

Gene Functionfor STAT5A

Pathways & Interactionsfor STAT5A

Drugs & Compoundsfor STAT5A

Transcriptsfor STAT5A

Expression for STAT5A

Orthologsfor STAT5A

Paralogsfor STAT5A

SNPs/Variantsfor STAT5A

Disorders & Mutationsfor STAT5A

Medical Newsfor STAT5A

Publicationsfor STAT5A

Search for STAT5A

Genome Databases showing STAT5A

Other Databases showing STAT5A

Specialized Databases showing STAT5A

Licensable Technologiesfor STAT5A

Servicesfor STAT5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for STAT5A

Summaries
for STAT5A

Genomic Location
for STAT5A

Proteins
for STAT5A

Protein Domains/
Families
for STAT5A

Gene Function
for STAT5A

Pathways & Interactions
for STAT5A

Drugs & Compounds
for STAT5A

Transcripts
for STAT5A

Expression
for STAT5A

Orthologs
for STAT5A

Paralogs
for STAT5A

SNPs/Variants
for STAT5A

Disorders & Mutations
for STAT5A

Medical News
for STAT5A

Publications
for STAT5A

Licensable Technologies
for STAT5A

Services
for STAT5A