External Ids for STAT4 Gene
Previous GeneCards Identifiers for STAT4 Gene
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
GeneCards Summary for STAT4 Gene
STAT4 (Signal Transducer And Activator Of Transcription 4) is a Protein Coding gene. Diseases associated with STAT4 include Systemic Lupus Erythematosus 11 and Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis. Among its related pathways are IL-2 Pathway and Th2 Differentiation Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is STAT1.
UniProtKB/Swiss-Prot for STAT4 Gene
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.