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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAT4 Gene

protein-coding GIFtS: 66
GCID: GC02M191894

signal transducer and activator of transcription 4

Explore 42 diseases affiliated with
STAT4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 4¹ ²
SLEB11² ⁵

External Ids:	HGNC: 11365¹	Entrez Gene: 6775²	Ensembl: ENSG00000138378⁷	OMIM: 600558⁵	UniProtKB: Q14765³

Export aliases for STAT4 gene to outside databases

Previous GC identifers: GC02M190088 GC02M190596 GC02M191858 GC02M192096 GC02M191719 GC02M191602 GC02M183754

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT4:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and

growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or

heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is

essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate

splicing results in multiple transcript variants that encode the same protein. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765

Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAT4 gene promoter:
c-Fos Bach1 GR AP-1 GATA-3 IRF-1 POU2F1 POU2F1a GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAT4 promoter sequence

Search SABiosciences Chromatin IP Primers for STAT4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2-q32.3 Ensembl cytogenetic band: 2q32.3 HGNC cytogenetic band: 2q32.2-q32.3

STAT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M191894: view genomic region (about GC identifiers)

Start:	191,894,302 bp from pter	End:	192,016,322 bp from pter
Size:	122,021 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765 (See protein sequence)

Recommended Name: Signal transducer and activator of transcription 4

Size: 748 amino acids; 85941 Da

Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The

SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain

Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation

Secondary accessions: Q96NZ6

Explore the universe of human proteins at neXtProt for STAT4: NX_Q14765

Post-translational modifications:

Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14765

STAT4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230764.1 NP_003142.1

ENSEMBL proteins:

ENSP00000351255 ENSP00000376134 ENSP00000403238 ENSP00000386288 ENSP00000412397

ENSP00000414322

Human Recombinant Protein Products for STAT4:

	EMD Millipore Purified and/or Recombinant STAT4 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: STAT4 OriGene Protein Over-expression Lysate: STAT4 OriGene Custom Protein Services for STAT4
	GenScript Custom Purified and Recombinant Proteins Services for STAT4
	Novus Biologicals STAT4 Protein Novus Biologicals STAT4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STAT4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

STAT4 for ontologies About GeneDecksing

STAT4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for STAT4
	Cell Signaling Technology (CST) Antibodies for STAT4
	OriGene Antibodies (see all 19): STAT4 OriGene Custom Antibody Services for STAT4
	GenScript Custom Superior Antibodies Services for STAT4
	Novus Biologicals STAT4 Antibodies
	Abcam antibodies for STAT4
	Uscn Antibodies for STAT4
	ThermoFisher Antibodies for STAT4

Assay Products for STAT4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for STAT4
	GenScript Custom Assay Services for STAT4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STAT4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAT4 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR013801 STAT_TF_DNA-bd

IPR008967 p53-like_TF_DNA-bd

IPR011992 EF-hand-like_dom

IPR013800 STAT_TF_alpha

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry Q14765

ProtoNet protein and cluster: Q14765

1 Blocks protein family: IPB001217 STAT protein

UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765

Similarity: Belongs to the transcription factor STAT family

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STAT4_HUMAN, Q14765

Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling

Genatlas biochemistry entry for STAT4:

signal transducer and activator of transcription 4,involved in IL12 signal transduction,expressed in spleen,heart,brain

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

STAT4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for STAT4:

Synthetic lethal with gemcitab

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Stat4):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	renal/urinary system

STAT4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for STAT4: Stat4^tm1Jni Stat4^tm1Gru

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STAT4

		10/175 SABiosciences Target genes for STAT4 (see all 175):
		ACCSL ACSM2A ADIG ADORA1 ADRB3 ALB ALG1 APBB2 ARID3B ASPHD2

miRNA Products:		OriGene 3'-UTR Clone: STAT4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT4
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT4:
		hsa-miR-141 hsa-miR-520d-5p hsa-miR-200a hsa-miR-524-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-29b-1*
		SwitchGear 3'UTR luciferase reporter plasmid: STAT4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT4 (see all 7) OriGene shRNA RFP: STAT4 OriGene siRNA: STAT4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT4
		Sirion Biotech Custom design and validation of potent shRNA sequences against STAT4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for STAT4
			Sirion Biotech Customized adenovirus for overexpression of STAT4 Sirion Biotech Customized adenovirus for potent knockdown of STAT4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAT4 (NM_003151)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STAT4
		Search LifeMap BioReagents cell lines for STAT4
		Sirion Biotech Customized stable knockdown cell line services for STAT4 Sirion Biotech Customized inducible knockdown cell line services for STAT4 Sirion Biotech Customized stable overexpressing cell line services for STAT4 Sirion Biotech Customized inducible overexpressing cell line services for STAT4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

CNTF Signaling

	CNTF Signaling	1.00			IL-3 Pathway	0.46
	FLT3 Signaling	0.50

Development_PDGF signaling via STATs and NF-kB

	Immune response_IL-23 signaling pathway	0.44			IL23-mediated signaling events	0.15
	Immune response IL-23 signaling pathway	0.41

Immune response IL-12 signaling pathway

Immune response IL-12 signaling pathway

1.00

Immune response_IL-12 signaling pathway

0.96

Immune response IL-22 signaling pathway

Immune response IL-22 signaling pathway

1.00

Immune response_IL-22 signaling pathway

0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for STAT4

	Immune response IL-23 signaling pathway
	Immune response IL-12-induced IFN-gamma production
	Immune response IL-22 signaling pathway
	Immune response IL-12 signaling pathway

2 R&D Systems Pathways for STAT4

	Th1 Differentiation
	Th17 Differentiation

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT4 (see all 12)

	ErbB2-ErbB3 Heterodimers
	FLT3 Signaling
	MAPK Signaling
	CNTF Signaling
	JAK-STAT Pathway

1 Cell Signaling Technology (CST) Pathway for STAT4

Jak/Stat Pathway

4 GeneGo (Thomson Reuters) Pathways for STAT4

	Immune response IL-12 signaling pathway
	Immune response IL-22 signaling pathway
	Immune response IL-12-induced IFN-gamma production
	Immune response IL-23 signaling pathway

5/6 BioSystems Pathways for STAT4 (see all 6)

	TSLP Signaling Pathway
	IL23-mediated signaling events
	IL12 signaling mediated by STAT4
	Downstream signaling in naive CD8+ T cells
	IL27-mediated signaling events

1 PharmGKB Pathway for STAT4

EGFR Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for STAT4):

Jak-STAT signaling pathway

STAT4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STAT4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for STAT4 (Q14765^{2, 3} ENSP00000351255⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL12RB2	Q99665²^,³, ENSP00000262345⁴	MINT-8033462 MINT-8033447 I2D: score=4 STRING: ENSP00000262345
NMI	Q13287³, ENSP00000243346⁴	I2D: score=4 STRING: ENSP00000243346
JUN	P05412³, ENSP00000360266⁴	I2D: score=3 STRING: ENSP00000360266
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=2 STRING: ENSP00000262367
MAP2K6	P52564³, ENSP00000351997⁴	I2D: score=2 STRING: ENSP00000351997

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006468	protein phosphorylation	IEA	--
GO:0007259	JAK-STAT cascade	TAS	9284918
GO:0008283	cell proliferation	IEA	--

STAT4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

STAT4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAT4
7 Novoseek chemical compound relationships for STAT4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il-12	57.1	5	15087447 (4), 15688366 (1)
tyrosine	50.9	49	8943379 (5), 9454765 (3), 10491012 (3), 10982828 (3) (see all 30)
serine	11.2	19	8943379 (3), 10820390 (2), 12407017 (2), 15004198 (2) (see all 6)
phosphotyrosine	7.73	3	9890938 (1), 10415122 (1)
allergens	0	1	15744455 (1)
phosphatidylinositol	0	2	10820390 (2)
dexamethasone	0	5	16670125 (2), 10657623 (2)

Search CenterWatch for drugs/clinical trials and news about STAT4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAT4 gene (2 alternative transcripts):

NM_001243835.1 NM_003151.3

Unigene Clusters for STAT4:

Signal transducer and activator of transcription 4

Hs.80642 [show with all ESTs], Hs.735572 [show with all ESTs]

Unigene Representative Sequences: NM_003151, AK001864

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000358470(uc010zgk.1 uc002usn.2) ENST00000392320(uc002usm.2)

ENST00000463951 ENST00000495849(uc002uso.2) ENST00000470708 ENST00000495326(uc002usp.4 uc010zgm.1 uc010zgn.1 uc010zgo.1)

ENST00000413064 ENST00000409995 ENST00000450994(uc010zgl.2) ENST00000432798

miRNA Products:		OriGene 3'-UTR Clone: STAT4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT4
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT4:
		hsa-miR-141 hsa-miR-520d-5p hsa-miR-200a hsa-miR-524-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-29b-1*
		SwitchGear 3'UTR luciferase reporter plasmid: STAT4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT4 (see all 7) OriGene shRNA RFP: STAT4 OriGene siRNA: STAT4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT4
		Sirion Biotech Custom design and validation of potent shRNA sequences against STAT4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAT4 (NM_003151)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STAT4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT4

Additional cDNA sequence:

AK001864.1 EU304791.1

8 DOTS entries:

DT.210252 DT.40117013 DT.120978346 DT.91830250 DT.92051150 DT.91757396 DT.97837346 DT.101962272

24/43 AceView cDNA sequences (see all 43):

BM918571 L78440 BC031212 NM_003151 AA310885 BM674243 AL046004 CB961839

BF056246 CD106642 AI669013 AW663965 BM715926 AW269424 CD521538 BG722188

CB993972 BG506572 BC016694 BX506073 BG718225 AL705314 BG057365 BX480276

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTTACAAT

About this image

STAT4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See STAT4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAT4

SOURCE GeneReport for Unigene clusters: Hs.80642 Hs.735572

SABiosciences Expression via Pathway-Focused PCR Arrays including STAT4 (see all 9):

Lymphoma in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Innate & Adaptive Immune Responses in human mouse rat

Th17 Response in human mouse rat

Neurotrophins & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat STAT4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STAT4 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STAT4¹	signal transducer and activator of transcription 4	80.21(n) 84.49(a)		768406 XM_001231298.2 XP_001231299.2
zebrafish (Danio rerio)	Actinopterygii	stat4¹	signal transducer and activator of transcription 4	64.6(n) 65.11(a)		368519 NM_001004510.1 NP_001004510.1
worm (Caenorhabditis elegans)	Secernentea	sta-1⁶ sta-2⁶	Signal transducer and activator of transcription 1... Signal transducer and activator of transcription b...	19(a) 16(a)	1 ↔ many possible ortholog	IV(16664287-16671437) V(9741198-9744206)

ENSEMBL Gene Tree for STAT4 (if available)
TreeFam Gene Tree for STAT4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAT4 gene

STAT5B² STAT1² STAT2² STAT6² STAT3² STAT5A²

8 SIMAP similar genes for STAT4 using alignment to 9 protein entries: STAT4_HUMAN (see all proteins):

STAT1 Stat2 STAT3 STAT2 STAT6 DKFZp686H05229

STAT5B STAT5A

STAT4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182079428^1,2		--	191893831(+)	`TTCTCC/GTAGTC`	2	--	ds500¹		0	--	--	--	--
rs3024910^1,2	C,F	--	191893871(-)	`AATTTA/TAAAAA`	2	--	ds500¹		3		NS WA	210
rs3024909^1,2	C,F	--	191893881(-)	`aaaaaA/-taata`	2	--	ds500¹		2		NS	94
rs73981213^1,2	C	--	191893935(+)	`TTGCCC/TAAGAT`	2	--	ds500¹		2		WA	120
rs145938013^1,2		--	191894012(+)	`ATAACA/GTTGAC`	2	--	ds500¹		0	--	--	--	--
rs113629611^1,2		--	191894059(+)	`GCCCCG/ATGAAT`	2	--	ds500¹		1		CSA	2
rs187220955^1,2		--	191894084(+)	`CATCAC/TGACTT`	2	--	ds500¹		0	--	--	--	--
rs143115571^1,2		--	191894092(+)	`CTTTCC/TTCTTG`	2	--	ds500¹		0	--	--	--	--
rs76353538^1,2	C	--	191894123(+)	`CCTGCC/TAGCGT`	2	--	ds500¹		0	--	--	--	--
rs3024908^1,2	C,F,H	--	191894141(-)	`AGCCAA/GTCAGT`	2	--	ds500¹		23		NS EA NA WA	2838

HapMap Linkage Disequilibrium report for STAT4 (191894302 - 192016322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STAT4
2 CNVs: 90190 63264
Human Gene Mutation Database (HGMD): STAT4

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STAT4 for disorders           About GeneDecksing

OMIM gene information: 600558
OMIM disorders: 180300  612253
UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765

Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11

(SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic

basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally

by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the

regulatory mechanisms of the autoimmune system

Genetic variations in STAT4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a

systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the

joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread

fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony

structures

20/42 diseases for STAT4 (see all 42): About MalaCards

systemic lupus erythematosus rheumatoid arthritis lupus erythematosus arthritis

inflammatory bowel disease sle susceptibility wegener's granulomatosis rheumatoid arthritis, association with

primary biliary cirrhosis chronic obstructive pulmonary disease allergic encephalomyelitis encephalomyelitis

acute lymphoblastic leukemia systemic scleroderma lymphoblastic leukemia lupus nephritis

antiphospholipid syndrome nephritis bronchiolitis pulmonary disease

2 diseases from the University of Copenhagen DISEASES database for STAT4:

Systemic lupus erythematosus Rheumatoid arthritis

10/16 Novoseek disease relationships for STAT4 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	55	12	18703106 (2), 18576330 (2), 19500629 (2), 20176035 (1) (see all 8)
rheumatoid arthritis	48.5	25	16760256 (2), 17932559 (2), 18432273 (2), 18576330 (2) (see all 20)
sezary syndrome	46.3	1	10491012 (1)
encephalomyelitis	27.9	1	17979888 (1)
colitis ulcerative	26.5	5	20176035 (1), 20454450 (1), 18759272 (1), 20153791 (1) (see all 5)
inflammatory bowel diseases	24.2	2	20454450 (1), 18759272 (1)
lupus erythematosus systemic	19.7	8	18432273 (2), 18803832 (2), 18576330 (2), 19717398 (2) (see all 18)
multiple sclerosis	15.7	1	17979888 (1)
inflammation	9.1	7	10779770 (2), 19359411 (1), 20176035 (1), 19796080 (1) (see all 6)
asthma	0	6	15744455 (2), 17404323 (1), 16301617 (1)

Genetic Association Database (GAD): STAT4
Human Genome Epidemiology (HuGE) Navigator: STAT4 (109 documents)

Export disorders for STAT4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STAT4 gene, integrated from 9 sources (see all 307):
(articles sorted by number of sources associating them with STAT4)

Utopia: connect your pdf to the dynamic
world of online information

Direct interaction of STAT4 with the IL-12 receptor. (PubMed id 10415122)^{1, 2, 9} Yao B.B.... Faltynek C.R. (1999)
Association analysis of signal transducer and activator of transcription 4 (STAT4) polymorphisms with asthma. (PubMed id 15744455)^{1, 4, 9} Park B.L....Shin H.D. (2005)
Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. (PubMed id 9890938)^{1, 2, 9} Naeger L.K.... Hoey T. (1999)
Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. (PubMed id 19109131)^{1, 2} Kariuki S.N....Niewold T.B. (2009)
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 17804842)^{1, 2} Remmers E.F....Gregersen P.K. (2007)
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. (PubMed id 15637551)^{1, 4} Pykalainen M....Lahesmaa R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. (PubMed id 8700208)^{1, 3} Thierfelder W.E....Ihle J.N. (1996)
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. (PubMed id 8007943)^{1, 3} Yamamoto K....Ihle J.N. (1994)
STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism. (PubMed id 16301617)^{1, 9} Shin H.J....Lee C.W. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6775	HGNC: 11365	AceView: STAT4	Ensembl:ENSG00000138378	euGenes: HUgn6775
ECgene: STAT4	Kegg: 6775	H-InvDB: STAT4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAT4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for STAT4	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/stat4/

Intellectual Property for STAT4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAT4 gene:
Search GeneIP for patents involving STAT4

GeneCards and IP:
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signal transducer and activator of transcription 4

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STAT4 Gene

signal transducer and activator of transcription 4

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