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STAT4 Gene

protein-coding   GIFtS: 66
GCID: GC02M191894

Signal Transducer And Activator Of Transcription 4

  See STAT4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducer And Activator Of Transcription 41 2
SLEB112 5

External Ids:    HGNC: 113651   Entrez Gene: 67752   Ensembl: ENSG000001383787   OMIM: 6005585   UniProtKB: Q147653   

Export aliases for STAT4 gene to outside databases

Previous GC identifers: GC02M190088 GC02M190596 GC02M191858 GC02M192096 GC02M191719 GC02M191602 GC02M183754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAT4 Gene:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines
and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form
homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This
protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T
helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid
arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. (provided by
RefSeq, Aug 2011)

GeneCards Summary for STAT4 Gene:
STAT4 (signal transducer and activator of transcription 4) is a protein-coding gene. Diseases associated with STAT4 include systemic lupus erythematosus, susceptitbility to, 11, and pediatric systemic lupus erythematosus. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12
signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAT4 gene promoter:
         c-Fos   Bach1   GR   AP-1   GATA-3   IRF-1   POU2F1   POU2F1a   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAT4 promoter sequence
   Search Chromatin IP Primers for STAT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2-q32.3   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q32.2-q32.3

STAT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M191894:  view genomic region     (about GC identifiers)

Start:
191,894,302 bp from pter      End:
192,016,322 bp from pter
Size:
122,021 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 4  
Size: 748 amino acids; 85941 Da
Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity).
The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain
Secondary accessions: Q96NZ6

Explore the universe of human proteins at neXtProt for STAT4: NX_Q14765

Explore proteomics data for STAT4 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STAT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230764.1  NP_003142.1  

    ENSEMBL proteins: 
     ENSP00000351255   ENSP00000376134   ENSP00000403238   ENSP00000386288   ENSP00000412397  
     ENSP00000414322  

    STAT4 Human Recombinant Protein Products:

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    OriGene MassSpec for STAT4
    OriGene Custom Protein Services for STAT4
    GenScript Custom Purified and Recombinant Proteins Services for STAT4
    Novus Biologicals STAT4 Protein
    Novus Biologicals STAT4 Lysates
    Sino Biological Recombinant Protein for STAT4
    Sino Biological Cell Lysate for STAT4
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT4

     
    Search eBioscience for Proteins for STAT4 

     
    antibodies-online proteins for STAT4 (4 products) 

     
    antibodies-online peptides for STAT4

    STAT4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for STAT4
    Cloud-Clone Corp. Antibodies for STAT4
    ThermoFisher Antibodies for STAT4
    antibodies-online antibodies for STAT4 (178 products) 

    STAT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STAT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT4
    Cloud-Clone Corp. CLIAs for STAT4
    Search eBioscience for ELISAs for STAT4 
    antibodies-online kits for STAT4 (28 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 9):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-dom_pair
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q14765

    ProtoNet protein and cluster: Q14765

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with STAT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT4_HUMAN, Q14765
    Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12
    signaling

         Genatlas biochemistry entry for STAT4:
    signal transducer and activator of transcription 4,involved in IL12 signal transduction,expressed in
    spleen,heart,brain

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with STAT4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAT4:
     Synthetic lethal with gemcitab 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stat4):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with STAT4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for STAT4: Stat4tm1Jni Stat4tm1Gru

       genOway: Develop your customized and physiologically relevant rodent model for STAT4

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NTTTCCAGGAAA 

    miRNA
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    Block miRNA regulation of human, mouse, rat STAT4 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate STAT4:
    hsa-miR-141 hsa-miR-520d-5p hsa-miR-200a hsa-miR-524-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSTAT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAT4
    Predesigned siRNA for gene silencing in human, mouse, rat STAT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT4

    Clone
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    OriGene clones in human, mouse for STAT4 (see all 6)
    OriGene ORF clones in mouse, rat for STAT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAT4 (NM_003151)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for STAT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAT4_HUMAN, Q14765: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with STAT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAT4 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    2Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    3IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33
    4CNTF Signaling
    CNTF Signaling0.50
    IL-3 Pathway0.46
    FLT3 Signaling0.50
    5GPCR Pathway
    GPCR Pathway0.62
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with STAT4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for STAT4
        Th1 Differentiation
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STAT4 (see all 12)
        ErbB2-ErbB3 Heterodimers
    FLT3 Signaling
    MAPK Signaling
    CNTF Signaling
    JAK-STAT Pathway

    1 Cell Signaling Technology (CST) Pathway for STAT4
        Jak/Stat Pathway

    4 GeneGo (Thomson Reuters) Pathways for STAT4
        Immune response IL-12 signaling pathway
    Immune response IL-22 signaling pathway
    Immune response IL-12-induced IFN-gamma production
    Immune response IL-23 signaling pathway

    Selected BioSystems Pathways for STAT4 (see all 7)
        Interferon type I
    TSLP Signaling Pathway
    IL27-mediated signaling events
    IL12-mediated signaling events
    IL12 signaling mediated by STAT4


    1 PharmGKB Pathway for STAT4
        EGFR Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for STAT4):
        Jak-STAT signaling pathway
    Hepatitis B
    Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT4 (see all 9): 
              Lymphoma in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAT4 (Q147652, 3 ENSP000003512554) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL12RB2Q996652, 3, ENSP000002623454MINT-8033462 MINT-8033447 I2D: score=4 STRING: ENSP00000262345
    NMIQ132873, ENSP000002433464I2D: score=4 STRING: ENSP00000243346
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    MAP2K6P525643, ENSP000003519974I2D: score=2 STRING: ENSP00000351997
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006468protein phosphorylation IEA--
    GO:0007165signal transduction ----
    GO:0007259JAK-STAT cascade TAS9284918

    Find genes that share ontologies with STAT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAT4

    7 Novoseek inferred chemical compound relationships for STAT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il-12 57.1 5 15087447 (4), 15688366 (1)
    tyrosine 50.9 49 8943379 (5), 9454765 (3), 10491012 (3), 10982828 (3) (see all 30)
    serine 11.2 19 8943379 (3), 10820390 (2), 12407017 (2), 15004198 (2) (see all 6)
    phosphotyrosine 7.73 3 9890938 (1), 10415122 (1)
    allergens 0 1 15744455 (1)
    phosphatidylinositol 0 2 10820390 (2)
    dexamethasone 0 5 16670125 (2), 10657623 (2)



    Find genes that share compounds with STAT4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAT4 gene (2 alternative transcripts): 
    NM_001243835.1  NM_003151.3  

    Unigene Cluster for STAT4:

    Signal transducer and activator of transcription 4
    Hs.80642  [show with all ESTs]
    Unigene Representative Sequence: NM_003151
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358470(uc010zgk.1 uc002usn.2) ENST00000392320(uc002usm.2)
    ENST00000463951 ENST00000495849(uc002uso.2) ENST00000470708 ENST00000495326(uc002usp.4 uc010zgm.1 uc010zgn.1 uc010zgo.1)
    ENST00000413064 ENST00000409995 ENST00000450994(uc010zgl.2) ENST00000432798

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate STAT4:
    hsa-miR-141 hsa-miR-520d-5p hsa-miR-200a hsa-miR-524-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSTAT4 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat STAT4
      QuantiFast Probe-based Assays in human, mouse, rat STAT4

    Additional mRNA sequence: 

    AB209043.1 AK299976.1 AK300868.1 AK301172.1 BC031212.1 EU304788.1 EU304789.1 EU304790.1 
    EU304792.1 EU304793.1 L78440.1 

    7 DOTS entries:

    DT.210252  DT.40117013  DT.120978346  DT.91757396  DT.92051150  DT.97837346  DT.101962272 

    Selected AceView cDNA sequences (see all 43):

    NM_003151 AA310885 L78440 BC031212 BM918571 BX506073 BM674243 CB993972 
    AI669013 AL705314 AL046004 BG718225 AW269424 BG722188 BG506572 AW663965 
    CD521538 CB961839 BC016694 BF056246 CD106642 BM715926 AA906053 BG057365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTACAAT
    STAT4 Expression
    About this image


    STAT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
    STAT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80642
        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT4 (see all 9): 
              Lymphoma in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat STAT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STAT4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat41 , 5 signal transducer and activator of transcription 41, 5 88.37(n)1
    94.79(a)1
      1 (26.67 cM)5
    208491  NM_011487.41  NP_035617.11 
     520082445 
    chicken
    (Gallus gallus)
    Aves STAT41 signal transducer and activator of transcription 4 80.04(n)
    84.22(a)
      768406  NM_001267555.1  NP_001254484.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stat41 signal transducer and activator of transcription 4 69.75(n)
    72.42(a)
      100496013  XM_002937442.2  XP_002937488.2 
    zebrafish
    (Danio rerio)
    Actinopterygii stat41 signal transducer and activator of transcription 4 64.55(n)
    65.11(a)
      368519  NM_001004510.1  NP_001004510.1 


    ENSEMBL Gene Tree for STAT4 (if available)
    TreeFam Gene Tree for STAT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAT4 gene
    STAT5B2  STAT12  STAT22  STAT32  STAT62  STAT5A2  
    8 SIMAP similar genes for STAT4 using alignment to 9 protein entries:     STAT4_HUMAN (see all proteins):
    STAT1    Stat2    STAT3    STAT2    STAT6    DKFZp686H05229
    STAT5B    STAT5A

    Find genes that share paralogs with STAT4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAT4 (see all 2492)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360024
    A breast cancer sample4--see VAR_0360022 E Q mis40--------
    rs1820794281,2
    --191279753(+) TTCTCC/GTAGTC 2 -- ds50010--------
    rs30249101,2
    C,F--191279793(-) AATTTA/TAAAAA 2 -- ds50013Minor allele frequency- T:0.05NS WA 210
    rs30249091,2
    C,F--191279803(-) aaaaaA/-taata 2 -- ds50012Minor allele frequency- -:0.03NS 94
    rs739812131,2
    C--191279857(+) TTGCCC/TAAGAT 2 -- ds50012Minor allele frequency- T:0.11WA 120
    rs1459380131,2
    --191279934(+) ATAACA/GTTGAC 2 -- ds50010--------
    rs1136296111,2
    F--191279981(+) GCCCCG/ATGAAT 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1872209551,2
    --191280006(+) CATCAC/TGACTT 2 -- ds50010--------
    rs1431155711,2
    --191280014(+) CTTTCC/TTCTTG 2 -- ds50010--------
    rs763535381,2
    C--191280045(+) CCTGCC/TAGCGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for STAT4 (191894302 - 192016322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for STAT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721280CNV Deletion23290073
    esv2721279CNV Deletion23290073
    esv2676475CNV Deletion23128226
    esv2721278CNV Deletion23290073
    esv2657029CNV Deletion23128226
    esv25901CNV Loss19812545
    nsv834493CNV Gain17160897
    nsv875623CNV Gain21882294

    Human Gene Mutation Database (HGMD): STAT4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT4
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600558   
    OMIM disorders: 612253  
    UniProtKB/Swiss-Prot: STAT4_HUMAN, Q14765
  • Systemic lupus erythematosus 11 (SLEB11) [MIM:612253]: A chronic, relapsing, inflammatory, and often
    febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin,
    joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the
    regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an
    elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 10 diseases for STAT4:    
    About MalaCards
    systemic lupus erythematosus, susceptitbility to, 11    pediatric systemic lupus erythematosus    oligoarticular juvenile arthritis    polyarticular onset juvenile idiopathic arthritis
    lupus erythematosus    behcet's disease    systemic lupus erythematosus    sle susceptibility
    rheumatoid arthritis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for STAT4:
    Systemic lupus erythematosus     Rheumatoid arthritis

    Find genes that share disorders with STAT4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for STAT4 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 55 12 18703106 (2), 18576330 (2), 19500629 (2), 20176035 (1) (see all 8)
    rheumatoid arthritis 48.5 25 16760256 (2), 17932559 (2), 18432273 (2), 18576330 (2) (see all 20)
    sezary syndrome 46.3 1 10491012 (1)
    encephalomyelitis 27.9 1 17979888 (1)
    colitis ulcerative 26.5 5 20176035 (1), 20454450 (1), 18759272 (1), 20153791 (1) (see all 5)
    inflammatory bowel diseases 24.2 2 20454450 (1), 18759272 (1)
    lupus erythematosus systemic 19.7 8 18432273 (2), 18803832 (2), 18576330 (2), 19717398 (2) (see all 18)
    multiple sclerosis 15.7 1 17979888 (1)
    inflammation 9.1 7 10779770 (2), 19359411 (1), 20176035 (1), 19796080 (1) (see all 6)
    asthma 0 6 15744455 (2), 17404323 (1), 16301617 (1)

    Genetic Association Database (GAD): STAT4
    Human Genome Epidemiology (HuGE) Navigator: STAT4 (109 documents)

    Export disorders for STAT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAT4 gene, integrated from 10 sources (see all 332):
    (articles sorted by number of sources associating them with STAT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 17804842)1, 2, 4 Remmers E.F.... Gregersen P.K. (N. Engl. J. Med. 2007)
    2. Direct interaction of STAT4 with the IL-12 receptor. (PubMed id 10415122)1, 2, 9 Yao B.B.... Faltynek C.R. (Arch. Biochem. Biophys. 1999)
    3. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. (PubMed id 18576330)1, 4, 9 Kobayashi S....Momohara S. (Arthritis Rheum. 2008)
    4. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. (PubMed id 18579578)1, 4, 9 Sigurdsson S....RAPnnblom L. (Hum. Mol. Genet. 2008)
    5. Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. (PubMed id 19404967)1, 4, 9 Daha N.A....Toes R.E. (Arthritis Rheum. 2009)
    6. High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. (PubMed id 19333953)1, 4, 9 Namjou B....Jacob C.O. (Arthritis Rheum. 2009)
    7. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. (PubMed id 18759272)1, 4, 9 MartA-nez A....Urcelay E. (Arthritis Rheum. 2008)
    8. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. (PubMed id 18803832)1, 4, 9 Kawasaki A....Tsuchiya N. (amp 2008)
    9. Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort. (PubMed id 19717398)1, 4, 9 Hellquist A....Kere J. (Ann. Rheum. Dis. 2010)
    10. A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus. (PubMed id 19762360)1, 4, 9 Svenungsson E....RAPnnblom L. (Ann. Rheum. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6775 HGNC: 11365 AceView: STAT4 Ensembl:ENSG00000138378 euGenes: HUgn6775
    ECgene: STAT4 Kegg: 6775 H-InvDB: STAT4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/stat4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAT4 gene:
    Search GeneIP for patents involving STAT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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