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Aliases for STAT4 Gene

Aliases for STAT4 Gene

  • Signal Transducer And Activator Of Transcription 4 2 3 5
  • SLEB11 3

External Ids for STAT4 Gene

Previous GeneCards Identifiers for STAT4 Gene

  • GC02M190088
  • GC02M190596
  • GC02M191858
  • GC02M192096
  • GC02M191719
  • GC02M191602
  • GC02M183754
  • GC02M191894

Summaries for STAT4 Gene

Entrez Gene Summary for STAT4 Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

GeneCards Summary for STAT4 Gene

STAT4 (Signal Transducer And Activator Of Transcription 4) is a Protein Coding gene. Diseases associated with STAT4 include systemic lupus erythematosus 11 and oligoarticular juvenile arthritis. Among its related pathways are Integrin Pathway and ERK Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is STAT2.

UniProtKB/Swiss-Prot for STAT4 Gene

  • Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT4 Gene

Genomics for STAT4 Gene

Regulatory Elements for STAT4 Gene

Genomic Location for STAT4 Gene

Chromosome:
2
Start:
191,029,576 bp from pter
End:
191,246,172 bp from pter
Size:
216,597 bases
Orientation:
Minus strand

Genomic View for STAT4 Gene

Genes around STAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT4 Gene

Proteins for STAT4 Gene

  • Protein details for STAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14765-STAT4_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 4
    Protein Accession:
    Q14765
    Secondary Accessions:
    • Q96NZ6

    Protein attributes for STAT4 Gene

    Size:
    748 amino acids
    Molecular mass:
    85941 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.

neXtProt entry for STAT4 Gene

Proteomics data for STAT4 Gene at MOPED

Post-translational modifications for STAT4 Gene

  • Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAT4 Gene

No data available for DME Specific Peptides for STAT4 Gene

Domains & Families for STAT4 Gene

Gene Families for STAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q14765

UniProtKB/Swiss-Prot:

STAT4_HUMAN :
  • Contains 1 SH2 domain.
  • Belongs to the transcription factor STAT family.
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT4: view

Function for STAT4 Gene

Molecular function for STAT4 Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription 4,involved in IL12 signal transduction,expressed in spleen,heart,brain
UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Gene Ontology (GO) - Molecular Function for STAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22740693
genes like me logo Genes that share ontologies with STAT4: view
genes like me logo Genes that share phenotypes with STAT4: view

Human Phenotype Ontology for STAT4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STAT4 Gene

MGI Knock Outs for STAT4:

Animal Model Products

miRNA for STAT4 Gene

miRTarBase miRNAs that target STAT4

Transcription Factor Targets for STAT4 Gene

Selected GeneGlobe predicted Target genes for STAT4
Targeted motifs for STAT4 Gene
HOMER Transcription Factor Regulatory Elements motif STAT4
  • Consensus sequence: NTTTCCAGGAAA Submotif: canonical Cell Type: CD4 GEO ID: GSE22104

No data available for Enzyme Numbers (IUBMB) for STAT4 Gene

Localization for STAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT4 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT4 Gene COMPARTMENTS Subcellular localization image for STAT4 gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 2
cytoskeleton 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with STAT4: view

Pathways & Interactions for STAT4 Gene

genes like me logo Genes that share pathways with STAT4: view

SIGNOR curated interactions for STAT4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with STAT4: view

Drugs & Compounds for STAT4 Gene

(4) Drugs for STAT4 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lisofylline Pharma 3

(4) Additional Compounds for STAT4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STAT4: view

Transcripts for STAT4 Gene

Unigene Clusters for STAT4 Gene

Signal transducer and activator of transcription 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAT4 Gene

No ASD Table

Relevant External Links for STAT4 Gene

GeneLoc Exon Structure for
STAT4
ECgene alternative splicing isoforms for
STAT4

Expression for STAT4 Gene

mRNA expression in normal human tissues for STAT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT4 Gene

This gene is overexpressed in Whole Blood (x5.6) and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for STAT4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.0), CD8 Tcells (15.2), Lymph node (9.4), and NK cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAT4 Gene



SOURCE GeneReport for Unigene cluster for STAT4 Gene Hs.80642

genes like me logo Genes that share expression patterns with STAT4: view

Protein tissue co-expression partners for STAT4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAT4 Gene

Orthologs for STAT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAT4 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia STAT4 36
  • 97 (a)
OneToOne
STAT4 35
  • 91.89 (n)
  • 96.66 (a)
dog
(Canis familiaris)
Mammalia STAT4 35
  • 91.8 (n)
  • 97.33 (a)
mouse
(Mus musculus)
Mammalia Stat4 35
  • 88.37 (n)
  • 94.79 (a)
Stat4 36
  • 95 (a)
OneToOne
Stat4 16
oppossum
(Monodelphis domestica)
Mammalia STAT4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAT4 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stat4 35
  • 88.24 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves STAT4 35
  • 80.04 (n)
  • 84.22 (a)
STAT4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stat4 35
  • 69.75 (n)
  • 72.42 (a)
zebrafish
(Danio rerio)
Actinopterygii stat4 36
  • 60 (a)
OneToOne
stat4 35
  • 64.55 (n)
  • 65.11 (a)
Species with no ortholog for STAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAT4 Gene

ENSEMBL:
Gene Tree for STAT4 (if available)
TreeFam:
Gene Tree for STAT4 (if available)

Paralogs for STAT4 Gene

Paralogs for STAT4 Gene

genes like me logo Genes that share paralogs with STAT4: view

Variants for STAT4 Gene

Sequence variations from dbSNP and Humsavar for STAT4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3024839 - 191,076,256(-) GGAGA(A/G)TATTG reference, missense
VAR_036002 A breast cancer sample
rs3024933 - 191,033,592(-) AGGAA(C/T)GGCTG reference, missense
rs921738 -- 191,225,505(+) TTCTA(C/T)TTTTA intron-variant
rs897200 -- 191,153,045(-) GCTAA(A/G)TAAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for STAT4 Gene

Variant ID Type Subtype PubMed ID
nsv834493 CNV Gain 17160897
esv2721278 CNV Deletion 23290073
esv2721279 CNV Deletion 23290073
esv2721280 CNV Deletion 23290073
esv2657029 CNV Deletion 23128226
esv2676475 CNV Deletion 23128226
esv25901 CNV Loss 19812545
nsv875623 CNV Gain 21882294

Variation tolerance for STAT4 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAT4 Gene

HapMap Linkage Disequilibrium report
STAT4
Human Gene Mutation Database (HGMD)
STAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT4 Gene

Disorders for STAT4 Gene

MalaCards: The human disease database

(14) MalaCards diseases for STAT4 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus 11
  • sleb11
oligoarticular juvenile arthritis
  • pauciarticular chronic arthritis
behcet's disease
  • adamantiades-behcet disease
lupus erythematosus
  • lupus
polyarticular onset juvenile idiopathic arthritis
  • juvenile polyarthritis rheumatoid factor negative
- elite association - COSMIC cancer census association via MalaCards
Search STAT4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STAT4_HUMAN
  • Systemic lupus erythematosus 11 (SLEB11) [MIM:612253]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:19109131}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17804842}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for STAT4

Genetic Association Database (GAD)
STAT4
Human Genome Epidemiology (HuGE) Navigator
STAT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAT4
genes like me logo Genes that share disorders with STAT4: view

No data available for Genatlas for STAT4 Gene

Publications for STAT4 Gene

  1. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. (PMID: 17804842) Remmers E.F. … Gregersen P.K. (N. Engl. J. Med. 2007) 3 4 48 67
  2. Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort. (PMID: 19717398) Hellquist A. … Kere J. (Ann. Rheum. Dis. 2010) 3 23
  3. A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus. (PMID: 19762360) Svenungsson E. … RAPnnblom L. (Ann. Rheum. Dis. 2010) 3 23
  4. Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. (PMID: 20454450) Glas J. … Brand S. (PLoS ONE 2010) 3 23
  5. Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis. (PMID: 19588142) Lee Y.H. … Song G.G. (Rheumatol. Int. 2010) 3 23

Products for STAT4 Gene

Sources for STAT4 Gene

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