Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAT3 Gene

protein-coding   GIFtS: 72
GCID: GC17M040465

signal transducer and activator of transcription 3 (acute-phase...
 Explore 210 diseases affiliated with
STAT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STAT3    

Aliases
for STAT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response
Factor)1 2
APRF1 2 3 5
Acute-Phase Response Factor2 3
HIES2 5
DNA-Binding Protein APRF2
Signal Transducer And Activator Of Transcription 32

External Ids:    HGNC: 113641   Entrez Gene: 67742   Ensembl: ENSG000001686107   OMIM: 1025825   UniProtKB: P407633   

Export aliases for STAT3 gene to outside databases

Previous GC identifers: GC17M040032 GC17M042622 GC17M040375 GC17M040840 GC17M037718 GC17M036231


Summaries
for STAT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STAT3:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,
STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that
translocate to the cell nucleus where they act as transcription activators. This protein is activated through
phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2.
This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in
many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate
the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced
transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
Function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and
other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the
interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated
by IL31 through IL31RA

summary for STAT3:
STATs (signal transducers and activators of transcription) are a family of 7 transcription factors that form
part of the JAK-STAT signaling cascade. This cascade is the basis of the signal transduction mechanism for
many cytokine receptors. Once activated by phosphorylation by JAKs, STATs translocate to the nucleus.
Accumulation of STATs in the nucleus is both rapid and tightly controlled. A number of factors regulate the
JAK-STAT pathway including STAT dephosphorylation by phosphatases, altered nuclear import-export dynamics of
STAT, and STAT gene activation antagonists such as SOCS (suppressors of cytokine signaling) and PIAS
(Protein Inhibitors of Activated STATs).

Gene Wiki entry for STAT3


Genomic Views
for STAT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAT3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STAT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for STAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

STAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040465:  view genomic region     (about GC identifiers)

Start:
 40,465,342 bp from pter      End:
 40,540,586 bp from pter
Size:
 75,245 bases      Orientation:
 minus strand

Proteins
for STAT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 3  
Size: 770 amino acids; 88068 Da
Subunit: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA,
NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence of
IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1
expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By
similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and
leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with
NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3.
Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity
of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3. Interacts with
STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the 'Lys-129' acetylated form of
BIRC5/survivin. Interacts with FER
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the
nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or
FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the
cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex
composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a
complex with LYN and PAG1
Miscellaneous: Involved in the gp130-mediated signaling pathway
Secondary accessions: A8K7B8 O14916 Q9BW54
Alternative splicing: 2 isoforms:  P40763-1   P40763-2   (Contains a phosphotyrosine at position 704)

Explore the universe of human proteins at neXtProt for STAT3: NX_P40763

Post-translational modifications:

  • Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated
    • FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine
    phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT
    promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine
    upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding
    STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of
    STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin
    treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphoryation at Tyr-705 by PTK6 or FER leads to an increase of its
    transcriptional activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40763

    • STAT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_003141.2  NP_644805.1  NP_998827.1  

    ENSEMBL proteins: 
     ENSP00000264657   ENSP00000467000   ENSP00000373923   ENSP00000467985   ENSP00000384943  
     ENSP00000467173  
    Reactome Protein details: P40763
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant STAT3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): STAT3
    OriGene Protein Over-expression Lysate (see all 2): STAT3
    OriGene Custom Protein Services for STAT3 
    GenScript Custom Purified and Recombinant Proteins Services for STAT3
    Novus Biologicals STAT3 Proteins
    Novus Biologicals STAT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STAT3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--


    STAT3 for ontologies           About GeneDecksing



    STAT3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT3
    R&D Systems Antibodies for STAT3
    Cell Signaling Technology (CST) Antibodies for STAT3 
    OriGene Antibodies (see all 9): STAT3
    OriGene Custom Antibody Services for STAT3 
    GenScript Custom Superior Antibodies Services for STAT3
    Novus Biologicals STAT3 Antibodies
    Abcam antibodies for STAT3 
    Uscn Antibodies for STAT3
    ThermoFisher Antibody for STAT3

    Assay Products for STAT3: 
    EMD Millipore Kits and Assays for the Analysis of STAT3
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for STAT3         (see all)
    GenScript Custom Assay Services for STAT3
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for STAT3

    Protein Domains /
    Families
    for STAT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STAT3 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-like_dom
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P40763

    ProtoNet protein and cluster: P40763

    1 Blocks protein family: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    Function
    for STAT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
    Function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and
    other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the
    interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated
    by IL31 through IL31RA

         Genatlas biochemistry entry for STAT3:
    signal transducer and activator of transcription 3,homologous to p91,component of the interferon stimulated gene factor
    3 complexes,involved in IL6 and related cytokines induced signal transduction by JAK kinases,also involved in the G1
    to S cell cycle transition,induced by IL6ST (GP130),playing a critical role in the maintenance of an undifferentiated
    ES phenotype,widely expressed,located in the cytoplasm and translocated to the nucleus after tyrosine
    phosphorylation,inhibited by protein phosphatase 2D,persistently activated in many cancers and transformed cell lines
    and required in cell culture for transformation and blocking of apoptosis

    10/1386 SABiosciences Target genes for STAT3 (see all 1386):
    A1BG A1CF AADACL3 ABCB4 ABHD1 ABHD3 ABL1 ACAA1 ACAD11 ACCS

    miRNA
    Products:            		miRTarBase miRNAs that target STAT3:
    hsa-mir-125b (MIRT005006), hsa-mir-20b (MIRT000497)

    OriGene 3'-UTR Clone (see all 3): STAT3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT3
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT3 (see all 80):
    hsa-miR-548j hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-629* hsa-miR-93 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: STAT3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT3 (see all 7)
    OriGene shRNA RFP: STAT3
    OriGene siRNA: STAT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STAT3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT3 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): STAT3 (NM_139276)
    Sino Biological Human cDNA Clone for STAT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for STAT3
    Search LifeMap BioReagents cell lines for STAT3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT3

    Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0001103RNA polymerase II repressing transcription factor binding IPI--
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7512451
    GO:0004871signal transducer activity TAS7512451


    STAT3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STAT3:
     Upregulation of NF-kappaB path 

    Animal Models:
         Mouse knock-outs for STAT3: Stat3tm1Aki Stat3tm1.1Xyfu Stat3tm2Vpo Stat3tm3Vpo Stat3tm1Desi
         15/23 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Stat3) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    STAT3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STAT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/94 super-pathways (see all 94) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IL-9 Signaling Pathways
    8/11 pathways (see all 11)
    		IL-9 Signaling Pathways1.00
    		IL-9 Signaling Pathway0.42
    		IL-21 Signaling Pathways0.90
    		Immune response_IL-9 signaling pathway0.42
    		IL-7 Signaling Pathways0.90
    		Immune response IL-9 signaling pathway0.42
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		IL-7 Signaling Pathway0.38
    2Development_PDGF signaling via STATs and NF-kB
    8/10 pathways (see all 10)
    		Development_PDGF signaling via STATs and NF-kB1.00
    		Development Angiopoietin - Tie2 signaling0.38
    		Development PDGF signaling via STATs and NF-kB1.00
    		Immune response_IL-10 signaling pathway0.28
    		Immune response_IL-23 signaling pathway0.44
    		Immune response IL-10 signaling pathway0.28
    		Immune response IL-23 signaling pathway0.41
    		IL23-mediated signaling events0.15
    3Development_CNTF receptor signaling
    		Development_CNTF receptor signaling1.00
    		Immune response IL-6 signaling pathway0.30
    		Development CNTF receptor signaling1.00
    		Development_Leptin signaling via JAK/STAT and MAPK cascades0.25
    		ErbB2/ErbB3 signaling events0.31
    		Development Leptin signaling via JAK/STAT and MAPK cascades0.25
    		Immune response_IL-6 signaling pathway0.30
    4Signaling by FGFR
    		Signaling by FGFR in disease0.91
    		NGF signalling via TRKA from the plasma membrane0.70
    		Downstream signal transduction0.84
    		Signalling by NGF0.52
    		Signaling by PDGF0.72
    5Development_Prolactin receptor signaling
    		Development_Prolactin receptor signaling1.00
    		Prolactin Signaling Pathway0.39
    		Development Prolactin receptor signaling1.00
    		Leptin signaling pathway0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/21 EMD Millipore Pathways for STAT3 (see all 21)
        Chemotaxis CXCR4 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response IL-9 signaling pathway
    Immune response IL-12 signaling pathway

    5/9 R&D Systems Pathways for STAT3 (see all 9)
        IL-21 Signaling Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling Pathways
    IL-7 Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT3 (see all 34)
        MAPK Signaling
    FLT3 Signaling
    IL-10 Pathway
    G-AlphaI Signaling
    PDGF Pathway

    1 Cell Signaling Technology (CST) Pathway for STAT3
        Jak/Stat Pathway

    1 Tocris Bioscience Pathway for STAT3
        MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for STAT3 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway

    5/43 BioSystems Pathways for STAT3 (see all 43) 
        Oncostatin M Signaling Pathway
    AGE/RAGE pathway
    EPO Receptor Signaling
    Adipogenesis
    EGFR1 Signaling Pathway

    5/20        Reactome Pathways for STAT3 (see all 20)
        Serine phosphorylation of STATs
    Signaling by FGFR1 mutants
    Disease
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for STAT3
        Busulfan Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics

    5/9         Kegg Pathways  (Kegg details for STAT3) (see all 9):
        Chemokine signaling pathway
    Jak-STAT signaling pathway
    Adipocytokine signaling pathway
    Toxoplasmosis
    Hepatitis C


    STAT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/795 Interacting proteins for STAT3 (P407631, 2, 3 ENSP000002646574) via UniProtKB, MINT, STRING, and/or I2D (see all 795)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GADD45GIP1Q8TAE82, 3, ENSP000003230654MINT-6492422 MINT-6492551 MINT-6492512 MINT-6492537 I2D: score=1 STRING: ENSP00000323065
    CSF3RQ990622, 3MINT-8037913 MINT-8037928 MINT-8035782 MINT-8035767 I2D: score=3 
    ERBB2P046262, 3, ENSP000002695714MINT-74756 MINT-8025768 MINT-8026372 I2D: score=2 STRING: ENSP00000269571
    STAT1P422242, 3, ENSP000003543944MINT-8034934 MINT-8034919 I2D: score=5 STRING: ENSP00000354394
    HDAC1Q135472, 3, ENSP000003626494MINT-8383061 MINT-7947479 I2D: score=4 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8675499
    GO:0001659temperature homeostasis ISS--
    GO:0001754eye photoreceptor cell differentiation ISS--
    GO:0006355regulation of transcription, DNA-dependent IDA15664994
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--


    STAT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for STAT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STAT3 for compounds           About GeneDecksing

    EMD Millipore small molecules for STAT3:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for STAT3

    Compounds for STAT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CryptotanshinoneSTAT3 inhibitor. Also displays multiple other activities[35825-57-1]
    StatticSelective STAT3 inhibitor[19983-44-9]
    Cucurbitacin ISelective inhibitor of STAT3/JAK2 signaling[2222-07-3]
    10/122 Novoseek chemical compound relationships for STAT3 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 92 215 19885008 (5), 18292512 (4), 7624343 (4), 10383440 (3) (see all 99)
    tyrosine 83.7 741 11751994 (5), 17531096 (5), 12738762 (4), 9344858 (4) (see all 99)
    cucurbitacin i 81.8 13 18200050 (3), 16707113 (3), 16939498 (1), 19843642 (1) (see all 9)
    atiprimod 73.2 7 17237271 (3), 16828865 (2), 15970928 (1), 15844657 (1)
    pd180970 67.5 3 10815799 (2), 12833138 (1)
    pd 98,059 61.1 38 17370312 (5), 12913253 (2), 18786965 (2), 10727406 (1) (see all 18)
    vegf 60.8 281 11960372 (7), 15312322 (7), 17937859 (7), 19020709 (6) (see all 87)
    ly294002 59.6 13 17234779 (2), 8955182 (1), 15514005 (1), 17237271 (1) (see all 11)
    phosphatidylinositol 56.9 39 9162009 (2), 17008315 (2), 15590660 (2), 12440226 (1) (see all 33)
    cucurbitacins 56.3 1 16707113 (1)

    Search CenterWatch for drugs/clinical trials and news about STAT3 

    Transcripts
    for STAT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STAT3 gene (3 alternative transcripts): 
    NM_003150.3  NM_139276.2  NM_213662.1  

    Unigene Cluster for STAT3:

    Signal transducer and activator of transcription 3 (acute-phase response factor)
    Hs.463059  [show with all ESTs]
    Unigene Representative Sequence: NM_139276
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264657(uc002hzk.1 uc002hzl.1 uc002hzm.1 uc010wgh.1 uc002hzn.1)
    ENST00000585517 ENST00000462286 ENST00000389272 ENST00000588969 ENST00000491272
    ENST00000404395 ENST00000462269 ENST00000471989 ENST00000498330 ENST00000478276
    ENST00000585360 ENST00000588065 ENST00000590776

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): STAT3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT3
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT3 (see all 80):
    hsa-miR-548j hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-629* hsa-miR-93 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: STAT3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT3 (see all 7)
    OriGene shRNA RFP: STAT3
    OriGene siRNA: STAT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT3 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): STAT3 (NM_139276)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT3
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT3

    Additional cDNA sequence: 

    AB451232.1 AF029311.1 AJ012463.1 AK024535.1 AK291933.1 AK297994.1 AK301200.1 AK316139.1 
    BC000627.2 BC008044.2 BC014482.1 BC067119.1 BC107775.1 

    24/29 DOTS entries (see all 29):

    DT.211127  DT.100031562  DT.95165134  DT.95165127  DT.100662067  DT.97810673  DT.95165131  DT.101963163 
    DT.40106148  DT.75112737  DT.91921971  DT.95376389  DT.121008645  DT.91700570  DT.95165138  DT.100655225 
    DT.100801462  DT.100831275  DT.121008511  DT.121008515  DT.121008542  DT.40295982  DT.75122302  DT.92010195 

    24/522 AceView cDNA sequences (see all 522):

    BX441253 BQ881070 AW152057 BM746435 CB216860 BQ889550 CA396565 BE908460 
    AI276576 BM550353 BQ670453 AA255469 BM912742 CB122210 BQ672301 AA374078 
    BG617189 AA057655 AI571562 CB215513 NM_139276 BX096773 CA394550 AA383745 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STAT3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                    -                                                                                               -                                       
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c · 24d · 24e
    SP1:                    -                                                   
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -           -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for STAT3

    Expression
    for STAT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCTGGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    STAT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneAutopod Long BoneBone
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    LimbAutopodLimb
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See STAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAT3

    SOURCE GeneReport for Unigene cluster: Hs.463059

    UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
    Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including STAT3 (see all 26): 
              Neurogenesis in human mouse rat
              HIV Host Response in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAT3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT3
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT3

    Orthologs
    for STAT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for STAT3 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves STAT31 signal transducer and activator of transcription 3 more 83.53(n)
    97.4(a)    		   420027  NM_001030931.1  NP_001026102.1 
    lizard
    (Anolis carolinensis)    		 Reptilia STAT36
    		 --
    		 96(a)
    		 1 ↔ 1
    		 6(72499188-72521804)
    African clawed frog
    (Xenopus laevis)    		 Amphibia stat3-A2 signal transducer and activator of transcription 3 more 78.25(n)    AB017701.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii stat32 signal transduction and activation of transcription more 77.75(n)   30767  AJ005693.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea sta-16
    sta-26
    		 Signal transducer and activator of transcription 1...
    Signal transducer and activator of transcription b...
    		 22(a)
    16(a)
    		 1 ↔ many
    possible ortholog
    		 IV(16664287-16671437)
    V(9741198-9744206)


    ENSEMBL Gene Tree for STAT3 (if available)
    TreeFam Gene Tree for STAT3 (if available) 

    Paralogs
    for STAT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAT3 gene
    STAT5B2  STAT12  STAT42  STAT22  STAT62  STAT5A2  
    8 SIMAP similar genes for STAT3 using alignment to 6 protein entries:     STAT3_HUMAN (see all proteins):
    STAT1    Stat2    STAT4    STAT6    STAT2    DKFZp686H05229
    STAT5B    STAT5A

    STAT3 for paralogs           About GeneDecksing



    Genomic Variants
    for STAT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1213 NCBI SNPs in STAT3 are shown (see all 1213)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs178820691,2
    		C,F,H,non-pathogenic38073195(-) ACGGAC/TGAGGA 6 D syn1 ese315Minor allele frequency- T:0.01NS NA EU 7071
    rs178820351,2
    		C,F,non-pathogenic38087385(-) TTACTC/GTTTTC 3 -- int1 trp34Minor allele frequency- G:0.02NS WA 270
    rs1139941351,2
    		Cpathogenic38081107(-) GATCCC/TGGAAA 6 R W mis10--------
    rs1139941361,2
    		Cpathogenic38081108(-) ATCCCA/G/TGAAAT 9 Q R L mis10--------
    rs1139941371,2
    		Cpathogenic38081327(-) GGGCCA/GAGCCA 6 Q R mis10--------
    rs1139941381,2
    		Cpathogenic38085712(-) TTGTG-/GTGATCTC 3 -- cds10--------
    rs1139941391,2
    		Cpathogenic38088276(-) AGTCCA/GTGGAA 6 M V mis10--------
    rs803505411,2
    		F,--36229544(+) TAGCTG/CAGGTT 3 -- ds50011Minor allele frequency- C:0.02WA 118
    rs2000297541,2
    		C--36230101(-) TTTGTC/TTNNNN 3 -- ut310--------
    rs107751,2
    		C--36230610(+) CTCCCC/ACTTAA 3 -- ut311Minor allele frequency- A:0.00MN 184

    HapMap Linkage Disequilibrium report for STAT3 (40465342 - 40540586 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for STAT3
         1 CNV: 102460
         2 Indels: 25843 67201
    Human Gene Mutation Database (HGMD): STAT3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAT3
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT3

    Disorders / Diseases
    for STAT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STAT3 for disorders           About GeneDecksing

    OMIM gene information: 102582   
    OMIM disorders: 147060  
    UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
  • Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant
    • (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and
    connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased
    serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints,
    and bone fractures

    20/210 diseases for STAT3 (see all 210):    About MalaCards
    hyper-ige syndrome    estrogen-receptor positive breast cancer    chronic inflammatory demyelinating polyradiculoneuropathy    eccrine porocarcinoma
    anaplastic large cell lymphoma    diffuse large b-cell lymphoma    cleft lip/palate    polycythemia vera
    gastrointestinal stromal tumor    mycosis fungoides    squamous cell carcinoma    non-small cell lung carcinoma
    actinic cheilitis    b-cell lymphomas    salivary gland cancer    cleft lip
    chronic myeloproliferative disease    familial medullary thyroid carcinoma    primitive neuroectodermal tumor    non-hodgkin lymphoma

    4 diseases from the University of Copenhagen DISEASES database for STAT3:
    Cancer     Job's syndrome     Vascular disease     Inflammatory bowel disease

    10/93 Novoseek disease relationships for STAT3 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyper-ige syndrome 74.6 23 17881745 (4), 20093388 (3), 19648655 (2), 18841165 (2) (see all 16)
    tumors 67.9 693 17824789 (5), 16536977 (5), 17015686 (5), 19244102 (5) (see all 99)
    response acute phase 66.5 51 7876144 (2), 17461989 (2), 7678052 (2), 8164674 (2) (see all 32)
    cancer 65.7 392 20072652 (5), 14659041 (5), 20026083 (5), 17311011 (5) (see all 99)
    leukemia 64.8 74 19074878 (5), 20133729 (4), 11337018 (3), 18047677 (2) (see all 57)
    hnscc 59.7 73 12782602 (7), 19638453 (7), 18172861 (5), 16642480 (4) (see all 22)
    myeloma 58.6 37 15958645 (3), 10023775 (3), 12953802 (3), 18824601 (2) (see all 21)
    anaplastic large cell lymphoma 53.5 13 17439836 (2), 14506160 (2), 15161657 (1), 18509351 (1) (see all 10)
    prostate cancer 51.3 167 18483213 (7), 20167868 (6), 10728680 (5), 12438264 (5) (see all 60)
    carcinoma squamous cell 47.4 66 12873986 (3), 17822622 (3), 17013800 (3), 18813829 (3) (see all 41)

    Genetic Association Database (GAD): STAT3
    Human Genome Epidemiology (HuGE) Navigator: STAT3 (76 documents)

    Export disorders for STAT3 gene to outside databases

    Publications
    for STAT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAT3 gene, integrated from 9 sources (see all 2648):
    (articles sorted by number of sources associating them with STAT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91- related transcription factor involved in the gp130-mediated signaling pathway. (PubMed id 7512451)1, 2, 3, 9 Akira S.... Kishimoto T. (1994)
    2. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PubMed id 12763138)1, 2, 9 Wierenga A.T....Vellenga E. (2003)
    3. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. (PubMed id 12873986)1, 2, 9 Shao H....Tweardy D.J. (2003)
    4. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1, 2, 9 Martens N....Gertler A. (2005)
    5. STAT3 mutations in the hyper-IgE syndrome. (PubMed id 17881745)1, 2, 9 Holland S.M.... Grimbacher B. (2007)
    6. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PubMed id 19147545)1, 2, 9 Zoubeidi A....Chevalier S. (2009)
    7. The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. (PubMed id 17956865)1, 2, 9 Hou T....Brasier A.R. (2007)
    8. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. (PubMed id 10688651)1, 2, 9 Tsai Y.T....Chen R.H. (2000)
    9. Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. (PubMed id 17875724)1, 2, 9 Aziz M.H....Verma A.K. (2007)
    10. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. (PubMed id 17676033)1, 2, 9 Minegishi Y....Karasuyama H. (2007)

    External Searches for STAT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STAT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6774 HGNC: 11364 AceView: STAT3 Ensembl:ENSG00000168610 euGenes: HUgn6774
    ECgene: STAT3 Kegg: 6774 H-InvDB: STAT3

    Other Databases showing STAT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STAT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/STAT3
    STAT3basehttp://bioinf.uta.fi/STAT3base/
    SeattleSNPshttp://pga.gs.washington.edu/data/stat3/

    Intellectual Property
    for STAT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STAT3 gene:
    Search GeneIP for patents involving STAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for STAT3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore small molecules (inhibitor) for STAT3
     EMD Millipore Kits and Assays for the Analysis of STAT3
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT3
     EMD Millipore Purified and/or Recombinant STAT3 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for STAT3 (STAT3)   Browse Cell Culture Products  
     ELISAs for STAT3 (STAT3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays for STAT3 (STAT3)  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for STAT3 (STAT3)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for STAT3   OriGene shRNA RFP for STAT3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT3  
     OriGene Protein Over-expression Lysate for STAT3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for STAT3   OriGene 3'-UTR Clone for STAT3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for STAT3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STAT3   OriGene Custom Protein Services for STAT3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAT3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAT3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT3
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT3
     GenScript Custom Purified and Recombinant Proteins Services for STAT3 GenScript cDNA clones with any tag delivered in your preferred vector for STAT3
     GenScript Custom Assay Services for STAT3 GenScript Custom Superior Antibodies Services for STAT3
     GenScript Custom overexpressing Cell Line Services for STAT3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for STAT3 

     Regulatory tfbs in STAT3 promoter
     Search Chromatin IP Primers for STAT3
     RT2 qPCR Primer Assay in human, mouse, rat STAT3
     GNC Network for STAT3
     SABiosciences PCR Arrays including human, mouse, rat STAT3
     Tocris compounds for STAT3
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for STAT3
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for STAT3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     STAT3 antibodies
     STAT3 proteins
     STAT3 lysates
     Antibodies for STAT3
     See all of Abcam's Antibodies, Kits and Proteins for STAT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     STAT3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for STAT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT3
     SwitchGear 3'UTR luciferase reporter plasmids for STAT3
     SwitchGear Promoter luciferase reporter plasmids for STAT3
     ThermoFisher Antibody for STAT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      STAT3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4