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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAT3 Gene

protein-coding   GIFtS: 72
GCID: GC17M040465

Signal Transducer And Activator Of Transcription 3 (Acute-Phase...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 3 (Acute-Phase
Response Factor)1 2
APRF2 3 5
Acute-Phase Response Factor2 3
HIES2 5
DNA-Binding Protein APRF2
Signal Transducer And Activator Of Transcription 32

External Ids:    HGNC: 113641   Entrez Gene: 67742   Ensembl: ENSG000001686107   OMIM: 1025825   UniProtKB: P407633   

Export aliases for STAT3 gene to outside databases

Previous GC identifers: GC17M040032 GC17M042622 GC17M040375 GC17M040840 GC17M037718 GC17M036231


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT3 Gene:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth
factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or
heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is
activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5,
IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli,
and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has
been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this
protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
(provided by RefSeq, Jul 2008)

GeneCards Summary for STAT3 Gene: 
STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor)) is a protein-coding gene. Diseases associated with STAT3 include hyper ige syndrome, and autosomal dominant hyper ige syndrome, and among its related super-pathways are IL-9 Signaling Pathways and Immune response IL-23 signaling pathway. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
Function: Signal transducer and transcription activator that mediates cellular responses to interleukins,
KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein
genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR
activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating
the expression of the antimicrobial lectin REG3G (By similarity)

summary for STAT3 Gene:
STATs (signal transducers and activators of transcription) are a family of 7 transcription factors that form
part of the JAK-STAT signaling cascade. This cascade is the basis of the signal transduction mechanism for
many cytokine receptors. Once activated by phosphorylation by JAKs, STATs translocate to the nucleus.
Accumulation of STATs in the nucleus is both rapid and tightly controlled. A number of factors regulate the
JAK-STAT pathway including STAT dephosphorylation by phosphatases, altered nuclear import-export dynamics of
STAT, and STAT gene activation antagonists such as SOCS (suppressors of cytokine signaling) and PIAS
(Protein Inhibitors of Activated STATs).

Gene Wiki entry for STAT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAT3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STAT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for STAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

STAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040465:  view genomic region     (about GC identifiers)

Start:
40,465,342 bp from pter      End:
40,540,586 bp from pter
Size:
75,245 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 3  
Size: 770 amino acids; 88068 Da
Subunit: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA,
NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with HCV core protein. Interacts with IL23R in presence
of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1
expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import
(By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of
CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2.
Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with
ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA
binding activity of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of
STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the 'Lys-129'
acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the
kinase catalytic domain)
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into
the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2,
FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present
in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus.
The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of
STAT3. Identified in a complex with LYN and PAG1
Miscellaneous: Involved in the gp130-mediated signaling pathway
Secondary accessions: A8K7B8 O14916 Q9BW54
Alternative splicing: 2 isoforms:  P40763-1   P40763-2   (Contains a phosphotyrosine at position 704)

Explore the universe of human proteins at neXtProt for STAT3: NX_P40763

Explore proteomics data for STAT3 at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated
    FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine
    phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT
    promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on
    serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable
    DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the
    phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1.
    Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphoryation at Tyr-705 by PTK6 or FER
    leads to an increase of its transcriptional activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40763

  • STAT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STAT3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_003141.2  NP_644805.1  NP_998827.1  

    ENSEMBL proteins: 
     ENSP00000264657   ENSP00000467000   ENSP00000373923   ENSP00000467985   ENSP00000384943  
     ENSP00000467173  
    Reactome Protein details: P40763
    Human Recombinant Protein Products for STAT3: 
    EMD Millipore Purified and/or Recombinant STAT3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for STAT3
    OriGene Protein Over-expression Lysate for STAT3
    OriGene MassSpec for STAT3 
    OriGene Custom Protein Services for STAT3
    GenScript Custom Purified and Recombinant Proteins Services for STAT3
    Novus Biologicals STAT3 Proteins
    Novus Biologicals STAT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--

    STAT3 for ontologies           About GeneDecksing



    STAT3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT3
    R&D Systems Antibodies for STAT3
    Cell Signaling Technology (CST) Antibodies for STAT3 
    OriGene Antibodies for STAT3
    OriGene Custom Antibody Services for STAT3
    GenScript Custom Superior Antibodies Services for STAT3
    Novus Biologicals STAT3 Antibodies
    Abcam antibodies for STAT3
    Cloud-Clone Corp. Antibodies for STAT3 
    ThermoFisher Antibody for STAT3
    LSBio Antibodies in human, mouse, rat for STAT3 

    Assay Products for STAT3: 
    EMD Millipore Kits and Assays for the Analysis of STAT3
    OriGene Custom Assay Services for STAT3
    R&D Systems ELISAs for STAT3         (see all)
    GenScript Custom Assay Services for STAT3
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT3 
    Cloud-Clone Corp. CLIAs for STAT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    5/9 InterPro protein domains (see all 9):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-like_dom
     IPR013800 STAT_TF_alpha
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P40763

    ProtoNet protein and cluster: P40763

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    STAT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT3_HUMAN, P40763
    Function: Signal transducer and transcription activator that mediates cellular responses to interleukins,
    KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
    Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein
    genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR
    activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating
    the expression of the antimicrobial lectin REG3G (By similarity)

         Genatlas biochemistry entry for STAT3:
    signal transducer and activator of transcription 3,homologous to p91,component of the interferon stimulated gene
    factor 3 complexes,involved in IL6 and related cytokines induced signal transduction by JAK kinases,also involved
    in the G1 to S cell cycle transition,induced by IL6ST (GP130),playing a critical role in the maintenance of an
    undifferentiated ES phenotype,widely expressed,located in the cytoplasm and translocated to the nucleus after
    tyrosine phosphorylation,inhibited by protein phosphatase 2D,persistently activated in many cancers and
    transformed cell lines and required in cell culture for transformation and blocking of apoptosis

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0001103RNA polymerase II repressing transcription factor binding IPI--
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7512451
    GO:0004871signal transducer activity TAS7512451
         
    STAT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STAT3:
     Upregulation of NF-kappaB path 

         15/23 MGI mutant phenotypes (inferred from 13 alleles(MGI details for Stat3) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    STAT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STAT3: Stat3tm1Aki Stat3tm1.1Xyfu Stat3tm2Vpo Stat3tm3Vpo Stat3tm1Desi

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STAT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT3 

    10/1368 SABiosciences Target genes for STAT3 (see all 1368):
    A1BG A1CF AADACL3 ABCB4 ABHD1 ABHD3 ABL1 ACAA1 ACAD11 ACCS

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT3:
    hsa-mir-125b (MIRT005006), hsa-mir-20b (MIRT000497)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT3
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT3 (see all 80):
    hsa-miR-548j hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-629* hsa-miR-93 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidSTAT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STAT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT3
    Sirion Biotech Customized adenovirus for overexpression of STAT3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STAT3 (see all 19)
    OriGene ORF clones in mouse, rat for STAT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): STAT3 (NM_139276)
    Sino Biological Human cDNA Clone for STAT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT3
    Sirion Biotech Customized lentivirus for stable overexpression of STAT3 
                         Customized lentivirus expression plasmids for stable overexpression of STAT3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT3
    Search LifeMap BioReagents cell lines for STAT3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STAT3 About   (see all 106)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    Immune response IL-9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    2Development PDGF signaling via STATs and NF-kB
    Immune response IL-23 signaling pathway0.91
    Immune response IL-10 signaling pathway0.38
    Development PDGF signaling via STATs and NF-kB0.44
    IL23-mediated signaling events0.38
    Development Angiopoietin - Tie2 signaling0.38
    Angiopoietin-TIE2 Signaling0.36
    3Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    4Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    EGF Pathway0.41
    5IL-2 Signaling pathway
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/21 EMD Millipore Pathways for STAT3 (see all 21)
        Chemotaxis CXCR4 signaling pathway
    Transcription Androgen Receptor nuclear signaling
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response IL-9 signaling pathway
    Immune response IL-12 signaling pathway

    5/10 R&D Systems Pathways for STAT3 (see all 10)
        IL-21 Signaling Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling Pathways
    IL-7 Signaling Pathways
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT3 (see all 34)
        MAPK Signaling
    FLT3 Signaling
    IL-10 Pathway
    G-AlphaI Signaling
    PDGF Pathway

    1 Cell Signaling Technology (CST) Pathway for STAT3
        Jak/Stat Pathway

    1 Tocris Bioscience Pathway for STAT3
        MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for STAT3 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway

    5/46 BioSystems Pathways for STAT3 (see all 46)
        MicroRNAs in cardiomyocyte hypertrophy
    TGF Beta Signaling Pathway
    EGFR1 Signaling Pathway
    Adipogenesis
    EPO Receptor Signaling

    1 Sino Biological Pathway for STAT3 
        EGFR Signaling Pathway

    5/17        Reactome Pathways for STAT3 (see all 17)
        Signaling by FGFR1 mutants
    Disease
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF

    2 PharmGKB Pathways for STAT3
        Busulfan Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics

    5/17         Kegg Pathways  (Kegg details for STAT3) (see all 17):
        Chemokine signaling pathway
    HIF-1 signaling pathway
    Jak-STAT signaling pathway
    Prolactin signaling pathway
    Adipocytokine signaling pathway


    STAT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/827 Interacting proteins for STAT3 (P407631, 2, 3 ENSP000002646574) via UniProtKB, MINT, STRING, and/or I2D (see all 827)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206206Q9UER71, 3EBI-518675,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-518675,EBI-77321 I2D: score=2 
    ENSG00000227046Q9UER71, 3EBI-518675,EBI-77321 I2D: score=2 
    ENSG00000231617Q9UER71, 3EBI-518675,EBI-77321 I2D: score=2 
    GADD45GIP1Q8TAE82, 3, ENSP000003230654MINT-6492422 MINT-6492551 MINT-6492512 MINT-6492537 I2D: score=1 STRING: ENSP00000323065
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8675499
    GO:0001659temperature homeostasis ISS--
    GO:0001754eye photoreceptor cell differentiation ISS--
    GO:0006355regulation of transcription, DNA-dependent IDA15664994
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--

    STAT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STAT3 for compounds           About GeneDecksing

    EMD Millipore small molecules for STAT3:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for STAT3

    Compounds for STAT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 74859Selective STAT3 inhibitor[501919-59-1]
    StatticSelective STAT3 inhibitor[19983-44-9]
    SD 1008JAK2/STAT3 signaling pathway inhibitor[960201-81-4]
    NiclosamideSTAT3 inhibitor; also inhibits mTORC1 signaling[50-65-7]
    Cucurbitacin ISelective inhibitor of STAT3/JAK2 signaling[2222-07-3]

    10/122 Novoseek inferred chemical compound relationships for STAT3 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 92 215 19885008 (5), 18292512 (4), 7624343 (4), 10383440 (3) (see all 99)
    tyrosine 83.7 741 11751994 (5), 17531096 (5), 12738762 (4), 9344858 (4) (see all 99)
    cucurbitacin i 81.8 13 18200050 (3), 16707113 (3), 16939498 (1), 19843642 (1) (see all 9)
    atiprimod 73.2 7 17237271 (3), 16828865 (2), 15970928 (1), 15844657 (1)
    pd180970 67.5 3 10815799 (2), 12833138 (1)
    pd 98,059 61.1 38 17370312 (5), 12913253 (2), 18786965 (2), 10727406 (1) (see all 18)
    vegf 60.8 281 11960372 (7), 15312322 (7), 17937859 (7), 19020709 (6) (see all 87)
    ly294002 59.6 13 17234779 (2), 8955182 (1), 15514005 (1), 17237271 (1) (see all 11)
    phosphatidylinositol 56.9 39 9162009 (2), 17008315 (2), 15590660 (2), 12440226 (1) (see all 33)
    cucurbitacins 56.3 1 16707113 (1)

    Search CenterWatch for drugs/clinical trials and news about STAT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STAT3 gene (3 alternative transcripts): 
    NM_003150.3  NM_139276.2  NM_213662.1  

    Unigene Cluster for STAT3:

    Signal transducer and activator of transcription 3 (acute-phase response factor)
    Hs.463059  [show with all ESTs]
    Unigene Representative Sequence: NM_139276
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264657(uc002hzk.1 uc002hzl.1 uc002hzm.1 uc010wgh.1 uc002hzn.1)
    ENST00000585517 ENST00000462286 ENST00000389272 ENST00000588969 ENST00000491272
    ENST00000404395 ENST00000462269 ENST00000471989 ENST00000498330 ENST00000478276
    ENST00000585360 ENST00000588065 ENST00000590776
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-548j hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-629* hsa-miR-93 hsa-miR-298
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    Additional mRNA sequence: 

    AB451232.1 AF029311.1 AJ012463.1 AK024535.1 AK291933.1 AK297994.1 AK301200.1 AK316139.1 
    BC000627.2 BC008044.2 BC014482.1 BC067119.1 BC107775.1 

    24/29 DOTS entries (see all 29):

    DT.211127  DT.100031562  DT.95165134  DT.95165127  DT.100662067  DT.97810673  DT.95165131  DT.101963163 
    DT.40106148  DT.75112737  DT.91921971  DT.95376389  DT.121008645  DT.91700570  DT.95165138  DT.100655225 
    DT.100801462  DT.100831275  DT.121008511  DT.121008515  DT.121008542  DT.40295982  DT.75122302  DT.92010195 

    24/522 AceView cDNA sequences (see all 522):

    AW152057 AA057655 BM558257 NM_213662 BU949932 AI276576 BQ881070 BQ955437 
    BE908460 NM_003150 AA383066 Z43321 AA065195 AI571562 BQ962161 BX441253 
    AJ012463 BU153877 CB215513 AA405488 H42927 BQ221473 AI867300 N51554 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STAT3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                    -                                                                                               -                                       
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c · 24d · 24e
    SP1:                    -                                                   
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -           -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for STAT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAT3 expression in normal human tissues (normalized intensities)      STAT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGGTCT
    STAT3 Expression
    About this image


    STAT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive Streak Cells Primitive Streak
             Primitive Streak
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             spinal/ganglion/dorsal root ganglion   

    See STAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAT3

    SOURCE GeneReport for Unigene cluster: Hs.463059

    UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
    Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including STAT3 (see all 26): 
              Neurogenesis in human mouse rat
              HIV Host Response in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STAT3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat31 , 5 signal transducer and activator of transcription 31, 5 91.37(n)1
    99.87(a)1
      11 (63.82 cM)5
    208481  NM_213660.21  NP_998825.11 
     1008850985 
    chicken
    (Gallus gallus)
    Aves STAT31 signal transducer and activator of transcription 3 more 83.53(n)
    97.4(a)
      420027  NM_001030931.1  NP_001026102.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAT36
    Uncharacterized protein
    96(a)
    1 ↔ 1
    6(72499174-72521804)
    African clawed frog
    (Xenopus laevis)
    Amphibia stat3-A2 signal transducer and activator of transcription 3 more 78.25(n)    AB017701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stat32 signal transduction and activation of transcription more 77.75(n)   30767  AJ005693.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sta-16
    Signal transducer and activator of transcription 1...
    20(a)
    1 → many
    IV(16664320-16671470)


    ENSEMBL Gene Tree for STAT3 (if available)
    TreeFam Gene Tree for STAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAT3 gene
    STAT5B2  STAT12  STAT42  STAT22  STAT62  STAT5A2  
    8 SIMAP similar genes for STAT3 using alignment to 6 protein entries:     STAT3_HUMAN (see all proteins):
    STAT1    Stat2    STAT4    STAT6    STAT2    DKFZp686H05229
    STAT5B    STAT5A

    STAT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1468 SNPs in STAT3 are shown (see all 1468)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0373694
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373692 F S mis40--------
    VAR_0373664
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373662 R Q mis40--------
    VAR_0373794
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373792 V M mis40--------
    VAR_0373724
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373722 H Y mis40--------
    VAR_0373674
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373672 R W mis40--------
    VAR_0373754
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373752 S N mis40--------
    VAR_0373684
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373682 F L mis40--------
    VAR_0373704
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373702 T I mis40--------
    VAR_0373654
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373652 R L mis40--------
    VAR_0373784
    Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES)4--see VAR_0373782 V L mis40--------

    HapMap Linkage Disequilibrium report for STAT3 (40465342 - 40540586 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for STAT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715948CNV Deletion23290073
    esv1069815CNV Deletion17803354
    nsv820731CNV Deletion20802225
    esv2667141CNV Deletion23128226
    esv2561210CNV Deletion19546169
    nsv908249CNV Loss21882294
    esv22090CNV Loss19812545
    nsv833449CNV Loss17160897
    nsv512487CNV Loss21212237
    nsv470586CNV Gain18288195


    Human Gene Mutation Database (HGMD): STAT3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 102582   
    OMIM disorders: 147060  
    UniProtKB/Swiss-Prot: STAT3_HUMAN, P40763
  • Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant (AD-HIES) [MIM:147060]: A rare
    disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent
    Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal
    dentition, hyperextensibility of the joints, and bone fractures. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/200 diseases for STAT3 (see all 200):    About MalaCards
    hyper ige syndrome    autosomal dominant hyper ige syndrome    primary cutaneous anaplastic large cell lymphoma    eccrine porocarcinoma
    chronic myeloproliferative disease    job's syndrome    familial medullary thyroid carcinoma    polyradiculoneuropathy
    chronic inflammatory demyelinating polyradiculoneuropathy    alk-positive anaplastic large cell lymphoma    cheilitis    actinic cheilitis
    anaplastic large cell lymphoma    primary immunodeficiency disease    lymphadenitis    salivary gland cancer
    pyogenic granuloma    chronic leukemia    follicular adenoma    hepatocellular adenoma

    5 diseases from the University of Copenhagen DISEASES database for STAT3:
    Cancer     Job's syndrome     Vascular disease     Inflammatory bowel disease
    Arthritis

    STAT3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for STAT3 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyper-ige syndrome 74.6 23 17881745 (4), 20093388 (3), 19648655 (2), 18841165 (2) (see all 16)
    tumors 67.9 693 17824789 (5), 16536977 (5), 17015686 (5), 19244102 (5) (see all 99)
    response acute phase 66.5 51 7876144 (2), 17461989 (2), 7678052 (2), 8164674 (2) (see all 32)
    cancer 65.7 392 20072652 (5), 14659041 (5), 20026083 (5), 17311011 (5) (see all 99)
    leukemia 64.8 74 19074878 (5), 20133729 (4), 11337018 (3), 18047677 (2) (see all 57)
    hnscc 59.7 73 12782602 (7), 19638453 (7), 18172861 (5), 16642480 (4) (see all 22)
    myeloma 58.6 37 15958645 (3), 10023775 (3), 12953802 (3), 18824601 (2) (see all 21)
    anaplastic large cell lymphoma 53.5 13 17439836 (2), 14506160 (2), 15161657 (1), 18509351 (1) (see all 10)
    prostate cancer 51.3 167 18483213 (7), 20167868 (6), 10728680 (5), 12438264 (5) (see all 60)
    carcinoma squamous cell 47.4 66 12873986 (3), 17822622 (3), 17013800 (3), 18813829 (3) (see all 41)

    Genetic Association Database (GAD): STAT3
    Human Genome Epidemiology (HuGE) Navigator: STAT3 (76 documents)

    Export disorders for STAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAT3 gene, integrated from 9 sources (see all 2775):
    (articles sorted by number of sources associating them with STAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91- related transcription factor involved in the gp130-mediated signaling pathway. (PubMed id 7512451)1, 2, 3, 9 Akira S.... Kishimoto T. (1994)
    2. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PubMed id 12763138)1, 2, 9 Wierenga A.T....Vellenga E. (2003)
    3. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. (PubMed id 12873986)1, 2, 9 Shao H....Tweardy D.J. (2003)
    4. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PubMed id 15677474)1, 2, 9 Martens N....Gertler A. (2005)
    5. Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the J apanese population. (PubMed id 19653082)1, 4, 9 Sato K....Tsukamoto K. (2009)
    6. STAT3 mutations in the hyper-IgE syndrome. (PubMed id 17881745)1, 2, 9 Holland S.M.... Grimbacher B. (2007)
    7. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PubMed id 19147545)1, 2, 9 Zoubeidi A....Chevalier S. (2009)
    8. STAT3 single-nucleotide polymorphisms and STAT3 mutations associated with hyper-IgE syndrome are not responsible for increased serum IgE serum levels in asthma families. (PubMed id 18841165)1, 4, 9 Wjst M....Grimbacher B. (2008)
    9. The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. (PubMed id 17956865)1, 2, 9 Hou T....Brasier A.R. (2007)
    10. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. (PubMed id 10688651)1, 2, 9 Tsai Y.T....Chen R.H. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6774 HGNC: 11364 AceView: STAT3 Ensembl:ENSG00000168610 euGenes: HUgn6774
    ECgene: STAT3 Kegg: 6774 H-InvDB: STAT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/STAT3
    STAT3basehttp://bioinf.uta.fi/STAT3base/
    SeattleSNPshttp://pga.gs.washington.edu/data/stat3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STAT3 gene:
    Search GeneIP for patents involving STAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     STAT3 lysates
     Antibodies for STAT3
     See all of Abcam's Antibodies, Kits and Proteins for STAT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for STAT3
     Antibodies for STAT3
     ELISAs for STAT3
     CLIAs for STAT3
     Search LifeMap BioReagents cell lines for STAT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT3
     SwitchGear 3'UTR luciferase reporter plasmids for STAT3
     SwitchGear Promoter luciferase reporter plasmids for STAT3
     ThermoFisher Antibody for STAT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STAT3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAT3
    Customized:
     lentivirus for stable overexpression of STAT3
     lentivirus expression plasmids for stable overexpression of STAT3
     adenovirus for overexpression of STAT3
     LSBio Antibodies in human, mouse, rat for STAT3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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