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STAT2 Gene

protein-coding   GIFtS: 68
GCID: GC12M056735

Signal Transducer And Activator Of Transcription 2, 113kDa

(Previous names: signal transducer and activator of transcription 2, 113kD)
  See STAT2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducer And Activator Of Transcription 2, 113kDa1 2     STAT1132
Signal Transducer And Activator Of Transcription 2, 113kD1     Interferon Alpha Induced Transcriptional Activator2
ISGF-32     Signal Transducer And Activator Of Transcription 22
P1132     p1133

External Ids:    HGNC: 113631   Entrez Gene: 67732   Ensembl: ENSG000001705817   OMIM: 6005565   UniProtKB: P526303   

Export aliases for STAT2 gene to outside databases

Previous GC identifers: GC12P056573 GC12P056545 GC12M056453 GC12M055022 GC12M055021 GC12M053774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAT2 Gene:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth
factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or
heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to
interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G),
in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor
P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be
involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

GeneCards Summary for STAT2 Gene:
STAT2 (signal transducer and activator of transcription 2, 113kDa) is a protein-coding gene. Diseases associated with STAT2 include mumps, and venezuelan equine encephalitis. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630
Function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and
IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated,
leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with
IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN
stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the
cell in an antiviral state

Gene Wiki entry for STAT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAT2 gene promoter:
         SRF   AML1a   Sp1   p53   SRF (504 AA)   Pax-2   Pax-2a   POU2F1   Pax-2b   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAT2 promoter sequence
   Search Chromatin IP Primers for STAT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2

STAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056735:  view genomic region     (about GC identifiers)

Start:
56,735,381 bp from pter      End:
56,754,037 bp from pter
Size:
18,657 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 2  
Size: 851 amino acids; 97916 Da
Subunit: Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the
interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts
with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the
interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with ARL2BP.
Interacts with dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral
proteins are present (polyprotein), targets STAT2 for degradation. Interacts with human cytomegalovirus/HHV-5
protein UL123; this interaction promotes viral growth. Interacts with Simian virus 5 protein V and rabies virus
phosphoprotein
Sequence caution: Sequence=AAB36226.1; Type=Erroneous gene model prediction; Sequence=AAB36227.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for STAT2:
2KA4 (3D)    
Secondary accessions: B4DLC7 G3V2M6 Q16430 Q16431 Q9UDL4
Alternative splicing: 2 isoforms:  P52630-3   P52630-4   (No experimental confirmation available. May be due to competing acceptor splice site)

Explore the universe of human proteins at neXtProt for STAT2: NX_P52630

Explore proteomics data for STAT2 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the
    transcriptional response1
  • Ubiquitination2 at Lys384, Lys523, Lys681
  • Modification sites at PhosphoSitePlus

  • See STAT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005410.1  NP_938146.1  

    ENSEMBL proteins: 
     ENSP00000315768   ENSP00000450751   ENSP00000387354   ENSP00000450985  
    Reactome Protein details: P52630

    STAT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STAT2
    OriGene Protein Over-expression Lysate for STAT2
    OriGene MassSpec for STAT2
    OriGene Custom Protein Services for STAT2
    GenScript Custom Purified and Recombinant Proteins Services for STAT2
    Novus Biologicals STAT2 Protein
    Novus Biologicals STAT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAT2

     
    Search eBioscience for Proteins for STAT2 

    STAT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT2
    R&D Systems Antibodies for STAT2
    OriGene Antibodies for STAT2
    OriGene Custom Antibody Services for STAT2
    Novus Biologicals STAT2 Antibodies
    Search for Antibodies for STAT2 at Abcam
    Cloud-Clone Corp. Antibodies for STAT2
    ThermoFisher Antibody for STAT2
    LSBio Antibodies in human, mouse, rat for STAT2

    STAT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAT2
    R&D Systems ELISAs for STAT2         (see all)
    GenScript Custom Assay Services for STAT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT2
    Cloud-Clone Corp. CLIAs for STAT2
    Search eBioscience for ELISAs for STAT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 10):
     IPR022756 STAT2_C
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-dom_pair
     IPR013800 STAT_TF_alpha

    Graphical View of Domain Structure for InterPro Entry P52630

    ProtoNet protein and cluster: P52630

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with STAT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT2_HUMAN, P52630
    Function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and
    IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated,
    leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with
    IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN
    stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the
    cell in an antiviral state

         Genatlas biochemistry entry for STAT2:
    signal transducer and activator of transcription,interacting specifically with CBP/p300 in signaling induced by
    interferon-alpha

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12220192
         
    Find genes that share ontologies with STAT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAT2:
     Upregulation of NF-kappaB path 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Stat2):
     hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with STAT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stat2tm1Shnd for STAT2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT2

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for STAT2 (see all 308):
    ABCD1,  ACAD11,  ACSM4,  AHCYL1,  AHSA1,  APLNR,  APOL4,  ARHGEF10,  ASB5,  ATF5

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT2:
    hsa-mir-125a-5p (MIRT045759), hsa-mir-335-5p (MIRT017906)

    Block miRNA regulation of human, mouse, rat STAT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAT2 (see all 10):
    hsa-miR-875-3p hsa-miR-767-3p hsa-miR-432 hsa-miR-1270 hsa-miR-587 hsa-miR-214 hsa-miR-620 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidSTAT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAT2
    Predesigned siRNA for gene silencing in human, mouse, rat STAT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT2

    Clone
    Products:
         
    OriGene clones in human, mouse for STAT2 (see all 10)
    OriGene ORF clones in mouse, rat for STAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STAT2 (NM_005419)
    Sino Biological Human cDNA Clone for STAT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT2
    Addgene plasmids for STAT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAT2_HUMAN, P52630: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with STAT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAT2 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    2Jak-STAT signaling pathway
    Jak-STAT signaling pathway
    Type III interferon signaling0.00
    3CNTF Signaling
    CNTF Signaling0.50
    IL-3 Pathway0.46
    FLT3 Signaling0.50
    4Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    5GPCR Pathway
    GPCR Pathway0.62
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with STAT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STAT2 (see all 12)
        ErbB2-ErbB3 Heterodimers
    FLT3 Signaling
    MAPK Signaling
    CNTF Signaling
    Interferon Pathway

    1 Cell Signaling Technology (CST) Pathway for STAT2
        Jak/Stat Pathway

    2 GeneGo (Thomson Reuters) Pathways for STAT2
        Immune response IFN gamma signaling pathway
    Immune response IFN alpha/beta signaling pathway

    Selected BioSystems Pathways for STAT2 (see all 7)
        EGFR1 Signaling Pathway
    Adipogenesis
    Type II interferon signaling (IFNG)
    Interferon type I
    Type III interferon signaling


    2 Reactome Pathways for STAT2
        Regulation of IFNA signaling
    Interferon alpha/beta signaling

    1 PharmGKB Pathway for STAT2
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for STAT2) (see all 8):
        Chemokine signaling pathway
    Osteoclast differentiation
    Jak-STAT signaling pathway
    Hepatitis C
    Hepatitis B

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT2: 
              Lung Cancer in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Transcription Factors in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAT2 (P526301, 2, 3 ENSP000003157684) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT1P422241, 2, 3, ENSP000003543944EBI-1546963,EBI-1057697 MINT-8030233 MINT-8030218 MINT-8030203 MINT-8033507 MINT-8033492 MINT-8033522 I2D: score=6 STRING: ENSP00000354394
    IFNAR1P171811, 2, 3, ENSP000002701394EBI-1546963,EBI-1547250 MINT-8029458 MINT-8029443 MINT-8029473 MINT-8029488 MINT-8029503 I2D: score=5 STRING: ENSP00000270139
    STAT2P526301, 2EBI-1546963,EBI-1546963 MINT-8033567 MINT-8033552 MINT-8033537
    IRF9Q009781, 3, ENSP000003800734EBI-1546963,EBI-626526 I2D: score=6 STRING: ENSP00000380073
    IFNAR2P485511, 3, ENSP000003439574EBI-1546963,EBI-958408 I2D: score=5 STRING: ENSP00000343957
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9020188
    GO:0007165signal transduction ----
    GO:0007259JAK-STAT cascade TAS9020188

    Find genes that share ontologies with STAT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    5 ApexBio Compounds for STAT2     About this table
    CompoundAction CAS #
    FludarabineChemotherapy agent[21679-14-1]
    NSC 74859STAT3 inhibitor, binds to STAT3 SH2 domain, inhibits STAT3-DNA binding[501919-59-1]
    SD 1008JAK2/STAT3 signaling pathway inhibitor[960201-81-4]
    StatticSmall molecule inhibitor of STAT3[19983-44-9]
    WP1066Cell permeable STAT3 inhibitor[857064-38-1]

    Browse Tocris compounds for STAT2

    Selected Novoseek inferred chemical compound relationships for STAT2 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    p113 87.4 15 7529187 (5), 7847880 (3), 7813427 (1), 8306959 (1) (see all 5)
    ifn-alpha 83.5 24 9576923 (3), 9804758 (3), 15175343 (2), 16571725 (2) (see all 12)
    tyrosine 70.4 85 15175343 (4), 8780896 (4), 8524306 (3), 17442890 (3) (see all 57)
    2',5'-oligoadenylate 70.1 2 19407486 (1), 11316742 (1)
    mumps 39.3 5 16051811 (2)
    retinoic acid 21.7 12 9186002 (3), 16918696 (2), 20137113 (2), 9028332 (1) (see all 5)
    phenylalanine 20.5 2 8605876 (1), 17442890 (1)
    genistein 19.2 1 17559358 (1)
    vanadate 10.4 1 11278370 (1)
    phosphotyrosine 7.37 1 7529187 (1)



    Find genes that share compounds with STAT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAT2 gene (2 alternative transcripts): 
    NM_005419.3  NM_198332.1  

    Unigene Cluster for STAT2:

    Signal transducer and activator of transcription 2, 113kDa
    Hs.530595  [show with all ESTs]
    Unigene Representative Sequence: NM_005419
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556539(uc001slb.3) ENST00000314128(uc001sld.3 uc001slc.3)
    ENST00000557235 ENST00000555488 ENST00000557199 ENST00000418572(uc010sqn.2)
    ENST00000555519 ENST00000557252 ENST00000556140 ENST00000557156 ENST00000557417
    ENST00000555646
    miRNA
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    Block miRNA regulation of human, mouse, rat STAT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAT2 (see all 10):
    hsa-miR-875-3p hsa-miR-767-3p hsa-miR-432 hsa-miR-1270 hsa-miR-587 hsa-miR-214 hsa-miR-620 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidSTAT2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for STAT2
    Predesigned siRNA for gene silencing in human, mouse, rat STAT2
    Clone
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    OriGene clones in human, mouse for STAT2 (see all 10)
    OriGene ORF clones in mouse, rat for STAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STAT2 (NM_005419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT2
    Addgene plasmids for STAT2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAT2
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT2
      QuantiTect SYBR Green Assays in human, mouse, rat STAT2
      QuantiFast Probe-based Assays in human, mouse, rat STAT2

    Additional mRNA sequence: 

    AK295052.1 AK295114.1 AK296939.1 AK296940.1 AK308051.1 AK310727.1 AK316516.1 BC006092.1 
    BC051284.1 BX640607.1 M97934.1 

    16 DOTS entries:

    DT.310717  DT.75117618  DT.40131255  DT.101984229  DT.121161045  DT.91785304  DT.100782911  DT.92046517 
    DT.95358195  DT.121161062  DT.75159957  DT.92421979  DT.95150985  DT.95265447  DT.97844110  DT.121196305 

    Selected AceView cDNA sequences (see all 236):

    AA983252 BQ421363 AI677742 AI650947 BG116555 BE766138 CA430537 AL702131 
    AI381287 AI866170 BM990571 BQ716359 BF434822 AI275630 AU121446 BU192342 
    AI685762 CR621797 AI720385 T29102 NM_005419 BM988418 AA974188 AI682359 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAT2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
    SP1:                                                  -     -                       -     -                 -                 -                             -   
    SP2:                          -                       -     -                                                                                                   
    SP3:                                                  -     -                                                                                                   
    SP4:                                                                                                                          -                                 
    SP5:                                                                                                                                                            

    ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:              -     -                 -                 -                                             
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                          -     -     -                                                               


    ECgene alternative splicing isoforms for STAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAACTCTA
    STAT2 Expression
    About this image


    STAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    STAT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530595
        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT2: 
              Lung Cancer in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Transcription Factors in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for STAT2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat21 , 5 signal transducer and activator of transcription 21, 5 77.17(n)1
    73.15(a)1
      10 (76.50 cM)5
    208471  NM_019963.11  NP_064347.11 
     1282705765 
    chicken
    (Gallus gallus)
    Aves STAT26
    signal transducer and activator of transcription 2...
    51(a)
    1 ↔ 1
    AADN03022145.1(191-2670)
    lizard
    (Anolis carolinensis)
    Reptilia STAT26
    signal transducer and activator of transcription 2...
    43(a)
    1 ↔ 1
    2(93300027-93335722)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia stat21 signal transducer and activator of transcription 2, more 56.03(n)
    47.64(a)
      100170174  NM_001129930.1  NP_001123402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stat26
    signal transducer and activator of transcription 2...
    37(a)
    1 ↔ 1
    6(39054408-39091286) ENSDARG00000031647
    fruit fly
    (Drosophila melanogaster)
    Insecta Stat92E6
    Signal-transducer and activator of transcription p...
    21(a)
    1 → many
    3R(16361405-16378034)
    worm
    (Caenorhabditis elegans)
    Secernentea sta-16
    Protein STA-1, isoform a (sta-1) mRNA, complete cd...
    19(a)
    1 → many
    IV(16664320-16671470) WBGene00013111


    ENSEMBL Gene Tree for STAT2 (if available)
    TreeFam Gene Tree for STAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAT2 gene
    STAT5B2  STAT12  STAT42  STAT32  STAT62  STAT5A2  
    7 SIMAP similar genes for STAT2 using alignment to 25 protein entries:     STAT2_HUMAN (see all proteins):
    DKFZp686H05229    Stat2    STAT1    STAT4    STAT3    STAT5A
    STAT6

    Find genes that share paralogs with STAT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAT2 (see all 502)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152003521,2
    C,F--56734964(+) CAAGGG/ATAGCT 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs115752521,2
    C,F--56735190(-) TTCTAG/CGGGTG 2 -- ds50018Minor allele frequency- C:0.02NS WA 960
    rs1915757701,2
    --56735213(+) CAGGAA/GGGGCT 2 -- ds50010--------
    rs79776921,2
    C,F--56735249(+) ATATGA/GCAAGA 2 -- ds50014Minor allele frequency- G:0.24NS WA CSA 302
    rs1477523191,2
    --56735270(+) GGGGTA/GGATGG 2 -- ds50010--------
    rs115752511,2
    C,H--56735382(-) CTGGAA/CATGTC 2 -- ut317Minor allele frequency- C:0.00NS EA NA 592
    rs1997147711,2
    C--56735456(-) GTTATG/TTCAGA 2 -- ut310--------
    rs1124169391,2
    C--56735465(+) ACAGAA/C/GAAGAA 4 -- ut311CSA 1
    rs1180648211,2
    F--56735578(+) GGTGTG/AAGATT 2 -- ut311Minor allele frequency- A:0.01NA 120
    rs562394201,2
    C,F--56735604(+) ACAGAC/TCTTCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for STAT2 (56735381 - 56754037 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STAT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482992CNV Complex15286789

    Human Gene Mutation Database (HGMD): STAT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600556    OMIM disorders: --

    3 diseases for STAT2:    
    About MalaCards
    mumps    venezuelan equine encephalitis    skin squamous cell carcinoma


    Find genes that share disorders with STAT2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for STAT2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parainfluenza 63.5 5 15604442 (2), 12504558 (1), 14698661 (1), 16051811 (1)
    mumps 35.6 5 16051811 (2)
    virus infection 32.9 2 17182562 (1), 16840335 (1)
    fibrosarcoma 32.4 3 7539922 (1), 15883164 (1)
    myeloid leukemia 23.1 3 9186002 (2), 9028332 (1)
    melanoma 15.6 9 9748142 (4), 15668815 (2), 9353349 (1), 20103601 (1)
    vesicular stomatitis 12 1 9915996 (1)
    metastasis 3.38 2 15668815 (1)
    tumors 2.79 10 9748142 (3), 15668815 (2), 15187113 (1), 17442890 (1) (see all 6)
    colon cancer 0 2 12972432 (1)

    Genetic Association Database (GAD): STAT2
    Human Genome Epidemiology (HuGE) Navigator: STAT2 (16 documents)

    Export disorders for STAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAT2 gene, integrated from 10 sources (see all 313):
    (articles sorted by number of sources associating them with STAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (PubMed id 7885841)1, 2, 3, 9 Yan R.... Darnell J.E. Jr. (Nucleic Acids Res. 1995)
    2. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. (PubMed id 9121453)1, 2, 9 Li X.... Stark G.R. (Mol. Cell. Biol. 1997)
    3. Role of metazoan mediator proteins in interferon-responsive transcription. (PubMed id 12509459)1, 2, 9 Lau J.F.... Horvath C.M. (Mol. Cell. Biol. 2003)
    4. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. (PubMed id 9020188)1, 2, 9 Bluyssen H.A. and Levy D.E. (J. Biol. Chem. 1997)
    5. Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. (PubMed id 18701593)1, 2, 9 Huh Y.H.... Ahn J.H. (J. Virol. 2008)
    6. Arginine/lysine-rich structural element is involved in interferon- induced nuclear import of STATs. (PubMed id 11150296)1, 2, 9 Melen K.... Julkunen I. (J. Biol. Chem. 2001)
    7. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. (PubMed id 1502204)1, 2, 9 Fu X.-Y.... Darnell J.E. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    8. Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses. (PubMed id 23139419)1, 2 Steen H.C.... Gamero A.M. (J. Biol. Chem. 2013)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6773 HGNC: 11363 AceView: STAT2 Ensembl:ENSG00000170581 euGenes: HUgn6773
    ECgene: STAT2 Kegg: 6773 H-InvDB: STAT2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/stat2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAT2 gene:
    Search GeneIP for patents involving STAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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