STAT2 Gene
protein-coding GIFtS: 66
GCID: GC12M056735
|
|
signal transducer and activator of transcription 2, 113kDa(Previous names: signal transducer and activator of transcription 2, 113kD...)
| |
Aliases
for STAT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Signal Transducer And Activator Of Transcription 2, 113kDa1 2 | | P1132 | | STAT1131 2 | | Interferon Alpha Induced Transcriptional Activator2 | | Signal Transducer And Activator Of Transcription 2, 113kD1 | | Signal Transducer And Activator Of Transcription 22 | | ISGF-32 | | P1132 |
Export aliases for STAT2 gene to outside databasesPrevious GC identifers: GC12P056573 GC12P056545 GC12M056453 GC12M055022 GC12M055021 GC12M053774 |
Summaries
for STAT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STAT2:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers thattranslocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), thisprotein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein actsas a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blockingIFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for thisgene. (provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630Function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha andIFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leadingto tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to forma complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated responseelement (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviralstate
Gene Wiki entry for STAT2
|
Genomic Views
for STAT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STAT2 gene promoter:
SRF AML1a Sp1 p53 SRF (504 AA) Pax-2 Pax-2a POU2F1 Pax-2b POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for STAT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.2STAT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M056735: view genomic region
(about GC identifiers)
Start:
|
56,735,381 bp from pter |
End:
|
56,754,037 bp from pter |
Size:
|
18,657 bases |
Orientation:
|
minus strand |
|
Proteins
for STAT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630 (See
protein sequence)Recommended Name: Signal transducer and activator of transcription 2 Size: 851 amino acids; 97916 Da
Subunit: Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta inducedphosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virusphosphoprotein (By similarity). Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1;the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with denguevirus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present(polyprotein), targets STAT2 for degradation. Interacts with human cytomegalovirus/HHV-5 protein UL123; thisinteraction promotes viral growth
Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta
Sequence caution: Sequence=AAB36226.1; Type=Erroneous gene model prediction; Sequence=AAB36227.1; Type=Erroneous genemodel prediction;
1 PDB 3D structure from  and Proteopedia  for STAT2:2KA4 (3D)
Secondary accessions: Q16430 Q16431 Q9UDL4Explore the universe of human proteins at neXtProt for STAT2: NX_P52630
Post-translational modifications:
Tyrosine phosphorylated in response to IFN-alpha1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52630
STAT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005410.1 NP_938146.1
ENSEMBL proteins: ENSP00000315768 ENSP00000450489 ENSP00000450751 ENSP00000387354 ENSP00000450985 Reactome Protein details: P52630
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
STAT2 for ontologies About GeneDecksing
STAT2 Antibody Products:
Assay Products for STAT2: |
Protein
Domains /
Families
for STAT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STAT2 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry P52630ProtoNet protein and cluster: P52630 1 Blocks protein family: IPB001217 STAT protein
UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630Similarity: Belongs to the transcription factor STAT familySimilarity: Contains 1 SH2 domain |
Function
for STAT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STAT2_HUMAN, P52630Function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha andIFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leadingto tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to forma complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated responseelement (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviralstate Genatlas biochemistry entry for STAT2:signal transducer and activator of transcription,interacting specifically with CBP/p300 in signaling induced byinterferon-alpha
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): STAT2 (NM_005419) | |  | Sino Biological Human cDNA Clone for STAT2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0004871 | signal transducer activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
STAT2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for STAT2:
Animal Models:
Mouse knock-out Stat2tm1Shnd for STAT2
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Stat2):
STAT2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STAT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | CNTF Signaling | | | 2 | Regulation of IFNA signaling | | | 3 | Immune response_IFN gamma signaling pathway | | | 4 | Cytokine Signaling in Immune system | | | 5 | GPCR Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for STAT2
5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT2 (see all 12)
1 
Cell Signaling Technology (CST) Pathway for STAT2
2  GeneGo (Thomson Reuters) Pathways for STAT2
5  BioSystems Pathways for STAT2
5 
Reactome Pathways for STAT2
1  PharmGKB Pathway for STAT2
5/6 
Kegg Pathways (Kegg details for STAT2) (see all 6):
STAT2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/101 Interacting proteins for STAT2 (P526301, 2, 3 ENSP000003157684) via UniProtKB, MINT, STRING, and/or I2D (see all 101)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| STAT1 | P422241, 2, 3, ENSP000003543944 | EBI-1546963,EBI-1057697 MINT-8030233 MINT-8030218 MINT-8030203 MINT-8033507 MINT-8033492 MINT-8033522 I2D:
score=6 STRING: ENSP00000354394 | | IFNAR1 | P171812, 3, ENSP000002701394 | MINT-8029458 MINT-8029443 MINT-8029473 MINT-8029488 MINT-8029503 I2D:
score=5 STRING: ENSP00000270139 | | IRF9 | Q009781, 3, ENSP000003800734 | EBI-1546963,EBI-626526 I2D:
score=6 STRING: ENSP00000380073 | | IFNAR2 | P485511, 3, ENSP000003439574 | EBI-1546963,EBI-958408 I2D:
score=5 STRING: ENSP00000343957 | | STAT2 | P526302 | MINT-8033567 MINT-8033552 MINT-8033537 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
STAT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for STAT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
STAT2 for compounds About GeneDecksing
 Browse Tocris compounds for STAT2
10/11 Novoseek chemical compound relationships for STAT2 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| p113 |
87.4 |
15 |
7529187 (5), 7847880 (3), 7813427 (1), 8306959 (1) (see all 5) |
| ifn-alpha |
83.5 |
24 |
9576923 (3), 9804758 (3), 15175343 (2), 16571725 (2) (see all 12) |
| tyrosine |
70.4 |
85 |
15175343 (4), 8780896 (4), 8524306 (3), 17442890 (3) (see all 57) |
| 2',5'-oligoadenylate |
70.1 |
2 |
19407486 (1), 11316742 (1) |
| mumps |
39.3 |
5 |
16051811 (2) |
| retinoic acid |
21.7 |
12 |
9186002 (3), 16918696 (2), 20137113 (2), 9028332 (1) (see all 5) |
| phenylalanine |
20.5 |
2 |
8605876 (1), 17442890 (1) |
| genistein |
19.2 |
1 |
17559358 (1) |
| vanadate |
10.4 |
1 |
11278370 (1) |
| phosphotyrosine |
7.37 |
1 |
7529187 (1) |
Search CenterWatch for drugs/clinical trials and news about STAT2
|
Transcripts
for STAT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STAT2 gene (2 alternative transcripts): NM_005419.3 NM_198332.1 Unigene Cluster for STAT2: Signal transducer and activator of transcription 2, 113kDa Hs.530595 [show with all ESTs]Unigene Representative Sequence: NM_00541913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000556539(uc001slb.3) ENST00000314128(uc001sld.3 uc001slc.3)
ENST00000555665 ENST00000557235 ENST00000555488 ENST00000557199 ENST00000418572(uc010sqn.2)
ENST00000555519 ENST00000557252 ENST00000556140 ENST00000557156 ENST00000557417
ENST00000555646
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): STAT2 (NM_005419) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT2 |
Additional cDNA sequence: AK295052.1 AK295114.1 AK296939.1 AK296940.1 AK308051.1 AK310727.1 AK316516.1 BC006092.1 BC051284.1 BX640607.1 M97934.1 16 DOTS entries: DT.310717 DT.75117618 DT.40131255 DT.101984229 DT.121161045 DT.91785304 DT.100782911 DT.92046517 DT.95358195 DT.121161062 DT.75159957 DT.92421979 DT.95150985 DT.95265447 DT.97844110 DT.121196305 24/236 AceView cDNA sequences (see all 236): AI720385 BC006092 AI685762 BU192342 BM988418 BE766138 AI650947 AA974188 BG116555 BP349518 CR621797 BM704003 AI268465 NM_005419 AI192822 AI682359 BQ775830 BC051284 AI381287 BM990571 M97934 AI677742 BQ716359 AI866170
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for STAT2 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STAT2
|
Expression
for STAT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STAT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAACTCTA
About this image
See STAT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAT2
SOURCE GeneReport for Unigene cluster: Hs.530595
SABiosciences Expression via Pathway-Focused PCR Arrays including STAT2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT2 |
Orthologs
for STAT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STAT2 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
55(a)37(a) |
1 ↔ many1 ↔ many |
2(93322838-93332719) 2(93304660-93322192) |
zebrafish
(Danio rerio) |
Actinopterygii |
stat26 |
signal transducer and activator of transcription 2... |
36(a) |
1 ↔ 1 |
6(39054408-39091286) |
worm
(Caenorhabditis elegans) |
Secernentea |
sta-16sta-26 |
Signal transducer and activator of transcription 1...Signal transducer and activator of transcription b... |
17(a)14(a) |
1 ↔ manypossible ortholog |
IV(16664287-16671437) V(9741198-9744206) |
ENSEMBL Gene Tree for STAT2 (if available)
TreeFam Gene Tree for STAT2 (if available) |
Paralogs
for STAT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STAT2 gene
- STAT5B2 STAT12 STAT42 STAT62 STAT32 STAT5A2
6 SIMAP similar genes for STAT2 using alignment to 6 protein entries: STAT2_HUMAN (see all proteins):DKFZp686H05229 Stat2 STAT1 STAT4 STAT3 STAT5A
STAT2 for paralogs About GeneDecksing
|
Genomic Variants
for STAT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STAT2 (56735381 - 56754037 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STAT2
1 CNV: 0164
Human Gene Mutation Database (HGMD): STAT2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAT2 |
|
Disorders
/ Diseases
for STAT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STAT2 for disorders About GeneDecksing
OMIM gene information: 600556
OMIM disorders: --
20/44  diseases for STAT2 (see all 44): About MalaCardsvenezuelan equine encephalitis human t-cell leukemia virus type 1 west nile virus dengue hemorrhagic fever
hemorrhagic fever skin squamous cell carcinoma mumps acute promyelocytic leukemia
squamous cell carcinoma stomatitis myeloid leukemia kaposi's sarcoma
cutaneous t cell lymphoma carcinoid tumors fibrosarcoma encephalitis
myxoma t-cell leukemia keratitis multiple sclerosis
10/12 Novoseek disease relationships for STAT2 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| parainfluenza |
63.5 |
5 |
15604442 (2), 12504558 (1), 14698661 (1), 16051811 (1) |
| mumps |
35.6 |
5 |
16051811 (2) |
| virus infection |
32.9 |
2 |
17182562 (1), 16840335 (1) |
| fibrosarcoma |
32.4 |
3 |
7539922 (1), 15883164 (1) |
| myeloid leukemia |
23.1 |
3 |
9186002 (2), 9028332 (1) |
| melanoma |
15.6 |
9 |
9748142 (4), 15668815 (2), 9353349 (1), 20103601 (1) |
| vesicular stomatitis |
12 |
1 |
9915996 (1) |
| metastasis |
3.38 |
2 |
15668815 (1) |
| tumors |
2.79 |
10 |
9748142 (3), 15668815 (2), 15187113 (1), 17442890 (1) (see all 6) |
| colon cancer |
0 |
2 |
12972432 (1) |
Human Genome Epidemiology (HuGE) Navigator: STAT2 (16 documents)
Export disorders for STAT2 gene to outside databases
|
Publications
for STAT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STAT2 gene, integrated from 9 sources (see all 301):
(articles sorted by number of sources associating them with STAT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (PubMed id 7885841)1, 2, 3, 9 Yan R.... Darnell J.E. Jr. (1995)
- Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. (PubMed id 9121453)1, 2, 9 Li X....Stark G.R. (1997)
- Role of metazoan mediator proteins in interferon-responsive transcription. (PubMed id 12509459)1, 2, 9 Lau J.F.... Horvath C.M. (2003)
- Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. (PubMed id 9020188)1, 2, 9 Bluyssen H.A. and Levy D.E. (1997)
- Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. (PubMed id 18701593)1, 2, 9 Huh Y.H....Ahn J.H. (2008)
- Arginine/lysine-rich structural element is involved in interferon- induced nuclear import of STATs. (PubMed id 11150296)1, 2, 9 Melen K.... Julkunen I. (2001)
- The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. (PubMed id 1502204)1, 2, 9 Fu X.-Y.... Darnell J.E. Jr. (1992)
- NS5 of dengue virus mediates STAT2 binding and degrad ation. (PubMed id 19279106)1, 2 Ashour J....GarcA-a-Sastre A. (2009)
- Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation. (PubMed id 19754307)1, 2 Mazzon M....Jacobs M. (2009)
- Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1. (PubMed id 16227264)1, 2 Precious B....Randall R.E. (2005)
|
External Searches for STAT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STAT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STAT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STAT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for STAT2 gene:
Search GeneIP for patents involving STAT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STAT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for STAT2 | | OriGene shRNA RFP for STAT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAT2 | | | OriGene Protein Over-expression Lysate for STAT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STAT2 | | OriGene 3'-UTR Clone for STAT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for STAT2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for STAT2 | | OriGene Custom Protein Services for STAT2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAT2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAT2 |
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| | | | Search Tocris compounds for STAT2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT2 |
|  |  |  | | | | ThermoFisher Antibody for STAT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT2 |
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