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Aliases for STAT2 Gene

Aliases for STAT2 Gene

  • Signal Transducer And Activator Of Transcription 2, 113kDa 2 3
  • Signal Transducer And Activator Of Transcription 2, 113kD 2 3
  • P113 3 4
  • Interferon Alpha Induced Transcriptional Activator 3
  • Signal Transducer And Activator Of Transcription 2 3
  • STAT113 3
  • ISGF-3 3

External Ids for STAT2 Gene

Previous GeneCards Identifiers for STAT2 Gene

  • GC12P056573
  • GC12P056545
  • GC12M056453
  • GC12M055022
  • GC12M055021
  • GC12M056735
  • GC12M053774

Summaries for STAT2 Gene

Entrez Gene Summary for STAT2 Gene

  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for STAT2 Gene

STAT2 (Signal Transducer And Activator Of Transcription 2, 113kDa) is a Protein Coding gene. Diseases associated with STAT2 include mumps and venezuelan equine encephalitis. Among its related pathways are Akt Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and identical protein binding. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot for STAT2 Gene

  • Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Gene Wiki entry for STAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT2 Gene

Genomics for STAT2 Gene

Regulatory Elements for STAT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STAT2 Gene

Start:
56,341,597 bp from pter
End:
56,360,271 bp from pter
Size:
18,675 bases
Orientation:
Minus strand

Genomic View for STAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT2 Gene

Proteins for STAT2 Gene

  • Protein details for STAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52630-STAT2_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 2
    Protein Accession:
    P52630
    Secondary Accessions:
    • B4DLC7
    • G3V2M6
    • Q16430
    • Q16431
    • Q9UDL4

    Protein attributes for STAT2 Gene

    Size:
    851 amino acids
    Molecular mass:
    97916 Da
    Quaternary structure:
    • Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at Tyr-466. Interacts with IFNAR2. Interacts with ARL2BP. Interacts with dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation. Interacts with human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.
    SequenceCaution:
    • Sequence=AAB36226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAB36227.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STAT2 Gene

    Alternative splice isoforms for STAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT2 Gene

Proteomics data for STAT2 Gene at MOPED

Post-translational modifications for STAT2 Gene

  • Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.
  • Ubiquitination at Lys384, Lys523, and Lys681
  • Modification sites at PhosphoSitePlus

Other Protein References for STAT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STAT2 Gene

Domains for STAT2 Gene

Gene Families for STAT2 Gene

HGNC:
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for STAT2 Gene

Graphical View of Domain Structure for InterPro Entry

P52630

UniProtKB/Swiss-Prot:

STAT2_HUMAN :
  • P52630
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT2: view

Function for STAT2 Gene

Molecular function for STAT2 Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription,interacting specifically with CBP/p300 in signaling induced by interferon-alpha
UniProtKB/Swiss-Prot Function:
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Gene Ontology (GO) - Molecular Function for STAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 12220192
genes like me logo Genes that share ontologies with STAT2: view

Phenotypes for STAT2 Gene

genes like me logo Genes that share phenotypes with STAT2: view

Animal Models for STAT2 Gene

MGI Knock Outs for STAT2:

Animal Model Products

miRNA for STAT2 Gene

miRTarBase miRNAs that target STAT2

Transcription Factor Targeting for STAT2 Gene

Selected GeneGlobe predicted Target genes for STAT2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for STAT2 Gene

Localization for STAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT2 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT2 Gene COMPARTMENTS Subcellular localization image for STAT2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for STAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with STAT2: view

Pathways for STAT2 Gene

genes like me logo Genes that share pathways with STAT2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for STAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9020188
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with STAT2: view

Compounds for STAT2 Gene

(11) Novoseek inferred chemical compound relationships for STAT2 Gene

Compound -log(P) Hits PubMed IDs
p113 87.4 11
ifn-alpha 83.5 20
tyrosine 70.4 68
2,5-oligoadenylate 70.1 2
mumps 39.3 2
genes like me logo Genes that share compounds with STAT2: view

Transcripts for STAT2 Gene

Unigene Clusters for STAT2 Gene

Signal transducer and activator of transcription 2, 113kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:

ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for STAT2 Gene

GeneLoc Exon Structure for
STAT2
ECgene alternative splicing isoforms for
STAT2

Expression for STAT2 Gene

mRNA expression in normal human tissues for STAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for STAT2 Gene

This gene is overexpressed in Monocytes (13.5), Bone marrow stromal cell (9.1), Lymph node (8.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAT2 Gene

SOURCE GeneReport for Unigene cluster for STAT2 Gene Hs.530595

genes like me logo Genes that share expressions with STAT2: view

Expression partners for STAT2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STAT2 Gene

Orthologs for STAT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAT2 35
  • 85.33 (n)
  • 81.42 (a)
STAT2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAT2 35
  • 87.65 (n)
  • 87.41 (a)
-- 36
  • 86 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Stat2 35
  • 77.17 (n)
  • 73.15 (a)
Stat2 16
Stat2 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAT2 35
  • 99.73 (n)
  • 99.53 (a)
STAT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stat2 35
  • 78.52 (n)
  • 74.82 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia STAT2 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAT2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAT2 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stat2 35
  • 56.03 (n)
  • 47.64 (a)
zebrafish
(Danio rerio)
Actinopterygii stat2 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sta-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
Species with no ortholog for STAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT2 Gene

ENSEMBL:
Gene Tree for STAT2 (if available)
TreeFam:
Gene Tree for STAT2 (if available)

Paralogs for STAT2 Gene

Paralogs for STAT2 Gene

genes like me logo Genes that share paralogs with STAT2: view

Variants for STAT2 Gene

Sequence variations from dbSNP and Humsavar for STAT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs762615 -- 56,356,090(-) GGAGC(A/T)GAGCA intron-variant
rs762616 -- 56,356,041(-) GGTGG(A/C)AAGGG intron-variant
rs762617 -- 56,355,409(-) GACAG(C/T)GTTCA intron-variant
rs762618 -- 56,351,534(-) TCTTC(A/T)CATAT intron-variant
rs762619 -- 56,351,525(-) ATTTA(C/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAT2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for STAT2 Gene

HapMap Linkage Disequilibrium report
STAT2
Human Gene Mutation Database (HGMD)
STAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT2 Gene

Disorders for STAT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for STAT2 Gene in MalaCards »

(3) Diseases for STAT2 Gene including...

(12) Novoseek inferred disease relationships for STAT2 Gene

Disease -log(P) Hits PubMed IDs
parainfluenza 63.5 5
mumps 35.6 2
virus infection 32.9 2
fibrosarcoma 32.4 2
myeloid leukemia 23.1 3

Relevant External Links for STAT2

Genetic Association Database (GAD)
STAT2
Human Genome Epidemiology (HuGE) Navigator
STAT2
genes like me logo Genes that share disorders with STAT2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for STAT2 Gene

Publications for STAT2 Gene

  1. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (PMID: 7885841) Yan R. … Darnell J.E. Jr. (Nucleic Acids Res. 1995) 2 3 4 23
  2. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. (PMID: 9020188) Bluyssen H.A. … Levy D.E. (J. Biol. Chem. 1997) 3 4 23
  3. Arginine/lysine-rich structural element is involved in interferon- induced nuclear import of STATs. (PMID: 11150296) Melen K. … Julkunen I. (J. Biol. Chem. 2001) 3 4 23
  4. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 4 23
  5. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. (PMID: 9121453) Li X. … Stark G.R. (Mol. Cell. Biol. 1997) 3 4 23

Products for STAT2 Gene

  • Addgene plasmids for STAT2

Sources for STAT2 Gene

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