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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAT1 Gene

protein-coding   GIFtS: 74
GCID: GC02M191829

Signal Transducer And Activator Of Transcription 1, 91kDa

(Previous names: signal transducer and activator of transcription 1, 91kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Transducer And Activator Of Transcription 1, 91kDa1 2     ISGF-32
Transcription Factor ISGF-3 Components P91/P841 2 3     STAT912
Signal Transducer And Activator Of Transcription 1, 91kD1     Signal Transducer And Activator Of Transcription 1-Alpha/Beta2
CANDF72     Signal Transducer And Activator Of Transcription-12

External Ids:    HGNC: 113621   Entrez Gene: 67722   Ensembl: ENSG000001154157   OMIM: 6005555   UniProtKB: P422243   

Export aliases for STAT1 gene to outside databases

Previous GC identifers: GC02M190028 GC02M190536 GC02M191797 GC02M192036 GC02M191659 GC02M191542 GC02M183693


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAT1 Gene:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth
factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or
heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be
activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein
mediates the expression of a variety of genes, which is thought to be important for cell viability in response to
different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAT1 Gene: 
STAT1 (signal transducer and activator of transcription 1, 91kDa) is a protein-coding gene. Diseases associated with STAT1 include human t-cell leukemia virus type 2, and candidiasis familial chronic mucocutaneous, autosomal recessive, and among its related super-pathways are IL-9 Signaling Pathways and Development Prolactin receptor signaling. GO annotations related to this gene include protein homodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224
Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),
cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding
to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and
to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to
form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated
response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an
antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then
forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma
activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1,
FGFR2, FGFR3 and FGFR4

Gene Wiki entry for STAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAT1 gene promoter:
         STAT5B   Max1   AP-1   IRF-1   S8   COMP1   FOXO1a   RSRFC4   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STAT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for STAT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2   Ensembl cytogenetic band:  2q32.2   HGNC cytogenetic band: 2q32.2-q32.3

STAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M191829:  view genomic region     (about GC identifiers)

Start:
191,829,084 bp from pter      End:
191,885,686 bp from pter
Size:
56,603 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 1-alpha/beta  
Size: 750 amino acids; 87335 Da
Subunit: Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon
IFN-alpha/beta induced phosphorylation. Interacts with NMI. Interacts with Sendai virus C', C, Y1 and Y2
proteins, Nipah virus P, V and W proteins, and rabies virus phosphoprotein preventing activation of ISRE and GAS
promoter (By similarity). Interacts with HCV core protein; the interaction results in STAT1 degradation.
Interacts with PIAS1; the interaction requires phosphorylation on Ser-727 and inhibits STAT1 activation.
Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with
IFNAR2. Interacts with PIAS1 (dimethylated on arginine); the interaction results in release of STAT1 from its
target gene. Interacts with SRC (By similarity). Interacts with ERBB4 (phosphorylated). Interacts with PTK2/FAK1
Subcellular location: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and
dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4
3 PDB 3D structures from and Proteopedia for STAT1:
1BF5 (3D)        1YVL (3D)        2KA6 (3D)    
Secondary accessions: A8K989 B2RCA0 D2KFR8 D3DPI7 Q53S88 Q53XW4 Q68D00 Q9UDL5
Alternative splicing: 2 isoforms:  P42224-1   P42224-2   

Explore the universe of human proteins at neXtProt for STAT1: NX_P42224

Explore proteomics data for STAT1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including
    IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent
    translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3
    and FGFR4. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes
    dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via
    JAK2. PHosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation,
    regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing
    interaction with PIAS. Phosphorylation on Ser-727 by PKCdelta induces apoptosis in response to DNA-damaging
    agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC
    family kinase
  • UniProtKB: Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727,
    and by interaction with PIAS proteins. Enhances the transactivation activity
  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42224

  • STAT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STAT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_009330.1  NP_644671.1  

    ENSEMBL proteins: 
     ENSP00000388240   ENSP00000354394   ENSP00000386244   ENSP00000388772   ENSP00000376136  
     ENSP00000394512   ENSP00000376137   ENSP00000402548   ENSP00000411398   ENSP00000416019  
     ENSP00000438703  
    Reactome Protein details: P42224
    Human Recombinant Protein Products for STAT1: 
    EMD Millipore Purified and/or Recombinant STAT1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for STAT1
    OriGene Protein Over-expression Lysate for STAT1
    OriGene MassSpec for STAT1 
    OriGene Custom Protein Services for STAT1
    GenScript Custom Purified and Recombinant Proteins Services for STAT1
    Novus Biologicals STAT1 Proteins
    Novus Biologicals STAT1 Lysates
    Sino Biological Recombinant Protein for STAT1
    Sino Biological Cell Lysate for STAT1 
    ProSpec Recombinant Protein for STAT1
    Cloud-Clone Corp. Proteins for STAT1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA18035482
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    STAT1 for ontologies           About GeneDecksing



    STAT1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT1
    R&D Systems Antibodies for STAT1
    Cell Signaling Technology (CST) Antibodies for STAT1 
    OriGene Antibodies for STAT1
    OriGene Custom Antibody Services for STAT1
    GenScript Custom Superior Antibodies Services for STAT1
    Novus Biologicals STAT1 Antibodies
    Abcam antibodies for STAT1
    Cloud-Clone Corp. Antibodies for STAT1 
    ThermoFisher Antibody for STAT1
    LSBio Antibodies in human, mouse, rat for STAT1 

    Assay Products for STAT1: 
    EMD Millipore Kits and Assays for the Analysis of STAT1
    OriGene Custom Assay Services for STAT1
    R&D Systems ELISAs for STAT1         (see all)
    GenScript Custom Assay Services for STAT1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT1 
    Cloud-Clone Corp. CLIAs for STAT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    5/10 InterPro protein domains (see all 10):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-like_dom
     IPR013800 STAT_TF_alpha
     IPR022752 STAT1_TAZ2-bd_C

    Graphical View of Domain Structure for InterPro Entry P42224

    ProtoNet protein and cluster: P42224

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    STAT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT1_HUMAN, P42224
    Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),
    cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding
    to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and
    to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to
    form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated
    response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an
    antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then
    forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma
    activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
    Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1,
    FGFR2, FGFR3 and FGFR4

         Genatlas biochemistry entry for STAT1:
    signal transducer and activator of transcription 1,91kDa,activated during monocyte to macrophage differentiation
    as an early transcription factor initially activated by adherence and then able to modulate the expression of
    functional genes such as ICAM1 and FCGR1

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA18035482
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA--
    GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IDA--
    GO:0003690double-stranded DNA binding IDA9630226
    GO:0003700NOT sequence-specific DNA binding transcription factor activity IDA10820245
         
    STAT1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for STAT1:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         15/19 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Stat1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  no phenotypic analysis 

    STAT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STAT1: Stat1tm1.2Mmul Stat1tm1Rds Stat1tm1Dlv

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STAT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT1 

    10/1062 SABiosciences Target genes for STAT1 (see all 1062):
    A3GALT2 ABCA1 ABCA4 ABCC13 ABI3BP ABL1 ACAA1 ACACB ACAP2 ACBD6

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT1:
    hsa-mir-145 (MIRT000626)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAT1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT1:
    hsa-miR-124* hsa-miR-495 hsa-miR-607 hsa-miR-186* hsa-miR-1252 hsa-miR-3182 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSTAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STAT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT1
    Sirion Biotech Customized adenovirus for overexpression of STAT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STAT1 (see all 13)
    OriGene ORF clones in mouse, rat for STAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STAT1 (NM_139266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT1
    Sirion Biotech Customized lentivirus for stable overexpression of STAT1 
                         Customized lentivirus expression plasmids for stable overexpression of STAT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT1
    Search LifeMap BioReagents cell lines for STAT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STAT1 About   (see all 87)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-7 Signaling Pathways0.90
    Immune response IL-9 signaling pathway0.42
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-9 Pathway0.36
    2Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    3Development EPO-induced Jak-STAT pathway
    Development EPO-induced Jak-STAT pathway0.42
    EPO signaling pathway0.34
    EPO Receptor Signaling0.42
    4Development PDGF signaling via STATs and NF-kB
    Immune response IL-23 signaling pathway0.91
    Immune response IL-10 signaling pathway0.38
    Development PDGF signaling via STATs and NF-kB0.44
    IL23-mediated signaling events0.38
    Development Angiopoietin - Tie2 signaling0.38
    5Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/16 EMD Millipore Pathways for STAT1 (see all 16)
        Cell adhesion PLAU signaling
    Immune response IL-9 signaling pathway
    Immune response IL-1 signaling pathway
    Development PDGF signaling via STATs and NF-kB
    Immune response IFN alpha/beta signaling pathway

    5/7 R&D Systems Pathways for STAT1 (see all 7)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-9 Signaling Pathways
    Th1 Differentiation
    IL-7 Signaling Pathways

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for STAT1 (see all 28)
        FLT3 Signaling
    MAPK Signaling
    BRCA1 Pathway
    Interferon Pathway
    PDGF Pathway

    1 Cell Signaling Technology (CST) Pathway for STAT1
        Jak/Stat Pathway

    1 Tocris Bioscience Pathway for STAT1
        MAPK Pathway

    5/19 GeneGo (Thomson Reuters) Pathways for STAT1 (see all 19)
        Immune response Bacterial infections in normal airways
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway

    5/47 BioSystems Pathways for STAT1 (see all 47)
        TGF Beta Signaling Pathway
    EGFR1 Signaling Pathway
    Adipogenesis
    p38 MAPK Signaling Pathway
    EPO Receptor Signaling

    1 Sino Biological Pathway for STAT1 
        EGFR Signaling Pathway

    5/21        Reactome Pathways for STAT1 (see all 21)
        Regulation of IFNA signaling
    Antiviral mechanism by IFN-stimulated genes
    Interferon alpha/beta signaling
    Signaling by FGFR1 mutants
    Disease

    1 PharmGKB Pathway for STAT1
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/16         Kegg Pathways  (Kegg details for STAT1) (see all 16):
        Chemokine signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway
    Prolactin signaling pathway


    STAT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/246 Interacting proteins for STAT1 (P422241, 2, 3 ENSP000003543944) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401892, 3, ENSP000003387994MINT-8030726 MINT-8028344 MINT-8028329 I2D: score=1 STRING: ENSP00000338799
    EGFRP005332, 3, ENSP000002754934MINT-8026146 MINT-8026130 I2D: score=5 STRING: ENSP00000275493
    STAT3P407632, 3, ENSP000002646574MINT-8034934 MINT-8034919 I2D: score=5 STRING: ENSP00000264657
    ERBB2P046262, 3, ENSP000002695714MINT-74754 MINT-74755 I2D: score=2 STRING: ENSP00000269571
    E2F1Q010941, 3, ENSP000003455714EBI-1057697,EBI-448924 I2D: score=1 STRING: ENSP00000345571
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001937negative regulation of endothelial cell proliferation IMP16585190
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--
    GO:0003340negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS--
    GO:0006351transcription, DNA-dependent ----

    STAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STAT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for STAT1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for STAT1

    Browse Tocris compounds for STAT1

    10/102 Novoseek inferred chemical compound relationships for STAT1 gene (see all 102)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 81.5 66 9804758 (5), 12967644 (3), 16169484 (3), 9576923 (2) (see all 35)
    tyrosine 81 490 7591091 (5), 8780896 (5), 9344858 (4), 18591661 (4) (see all 99)
    gp 130 76.9 33 8662591 (4), 8662795 (3), 18431520 (2), 18292512 (2) (see all 21)
    2',5'-oligoadenylate 71.1 6 20014458 (1), 16297951 (1), 19407486 (1), 11316742 (1) (see all 6)
    serine 57.3 149 10940874 (5), 9399961 (4), 12018856 (4), 11839738 (3) (see all 70)
    cgp77675 56.2 2 11840778 (1), 14521054 (1)
    15-deoxy-delta-12,14-prostaglandin j2 49.8 18 12517740 (4), 12847270 (3), 11971025 (1), 12584205 (1) (see all 6)
    piceatannol 48.7 8 10777558 (2), 18664717 (2), 15022320 (1), 19796718 (1) (see all 6)
    sam 486a 47.7 1 15547724 (1)
    ly294002 47.4 12 15728510 (2), 12807916 (2), 15994321 (1), 19103208 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about STAT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STAT1 gene (2 alternative transcripts): 
    NM_007315.3  NM_139266.2  

    Unigene Cluster for STAT1:

    Signal transducer and activator of transcription 1, 91kDa
    Hs.743244  [show with all ESTs]
    Unigene Representative Sequence: NM_007315
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415035 ENST00000361099(uc021vue.1 uc010fse.2 uc002usj.2 uc010fsf.1)
    ENST00000409465 ENST00000423282 ENST00000392322(uc002usk.2) ENST00000452281
    ENST00000392323(uc002usl.2) ENST00000464072 ENST00000424722 ENST00000454414
    ENST00000432058 ENST00000540176
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate STAT1:
    hsa-miR-124* hsa-miR-495 hsa-miR-607 hsa-miR-186* hsa-miR-1252 hsa-miR-3182 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSTAT1 3' UTR sequence
    Inhib. RNA
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    OriGene clones in human, mouse for STAT1 (see all 13)
    OriGene ORF clones in mouse, rat for STAT1
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    GenScript: all cDNA clones in your preferred vector (see all 2): STAT1 (NM_139266)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT1
    Sirion Biotech Customized lentivirus for stable overexpression of STAT1 
                         Customized lentivirus expression plasmids for stable overexpression of STAT1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAT1

    Additional mRNA sequence: 

    AK096686.1 AK225853.1 AK292604.1 AK315002.1 BC002704.2 BC141921.1 BT007241.1 CR749636.1 
    GU211347.1 GU211348.1 

    24/29 DOTS entries (see all 29):

    DT.100739821  DT.92455188  DT.452728  DT.100035277  DT.97864339  DT.100643442  DT.95365803  DT.95079173 
    DT.95255474  DT.100675080  DT.100675074  DT.95365811  DT.95365817  DT.92411698  DT.100857914  DT.92455176 
    DT.100675077  DT.120972049  DT.97825859  DT.99939433  DT.120972126  DT.120972162  DT.40308326  DT.75155917 

    24/557 AceView cDNA sequences (see all 557):

    BM726325 BF002752 AI253770 BF942160 AA478534 BQ957446 AL047386 CB529176 
    AI690563 AU122512 BQ434711 BM977450 AA465005 BQ710422 AI364640 BU615695 
    AI470989 BQ937947 CB148144 BM712397 BQ929939 BG678000 AW243715 AI859876 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for STAT1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                                                                                                                                                            
    SP2:                                      -                                                                                                                     
    SP3:                                      -                                                                                                                     
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
    SP1:              -                       -                                       
    SP2:              -                       -                       -               
    SP3:              -                       -                                       
    SP4:                                                                              
    SP5:              -                                                               


    ECgene alternative splicing isoforms for STAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAT1 expression in normal human tissues (normalized intensities)      STAT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATGCTGT
    STAT1 Expression
    About this image


    STAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Chondrocytes Sacral Vertebrae
     
     Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
             Chondrocytes Sacral Vertebrae
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See STAT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAT1

    SOURCE GeneReport for Unigene cluster: Hs.743244
        SABiosciences Expression via Pathway-Focused PCR Arrays including STAT1 (see all 22): 
              Lung Cancer in human mouse rat
              HIV Host Response in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Antiviral Response in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STAT1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat11 , 5 signal transducer and activator of transcription 11, 5 86.74(n)1
    93.59(a)1
      1 (26.81 cM)5
    208461  NM_001205313.11  NP_001192242.11 
     521194385 
    chicken
    (Gallus gallus)
    Aves STAT11 signal transducer and activator of transcription 1, more 76.24(n)
    84.3(a)
      424044  NM_001012914.1  NP_001012932.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAT16
    Uncharacterized protein
    42(a)
    1 ↔ 1
    2(134110585-134219572)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983242 Stat1 76.56(n)    AY101602.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stat12 signal transduction and activation of transcription more 75.46(n)   30768  BC060933.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sta-16
    Signal transducer and activator of transcription 1...
    21(a)
    1 → many
    IV(16664320-16671470)


    ENSEMBL Gene Tree for STAT1 (if available)
    TreeFam Gene Tree for STAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAT1 gene
    STAT5B2  STAT42  STAT22  STAT32  STAT62  STAT5A2  
    7 SIMAP similar genes for STAT1 using alignment to 10 protein entries:     STAT1_HUMAN (see all proteins):
    STAT4    STAT3    Stat2    STAT2    DKFZp686H05229    STAT5A
    STAT5B

    STAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1154 SNPs in STAT1 are shown (see all 1154)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659414
    Familial candidiasis 7 (CANDF7)4--see VAR_0659412 Q P mis40--------
    VAR_0360014
    A breast cancer sample4--see VAR_0360012 P A mis40--------
    VAR_0659364
    Familial candidiasis 7 (CANDF7)4--see VAR_0659362 Y N mis40--------
    VAR_0658174
    Mendelian susceptibility to mycobacterial disease (MSMD)4--see VAR_0658172 Q H mis40--------
    VAR_0659404
    Familial candidiasis 7 (CANDF7)4--see VAR_0659402 A V mis40--------
    VAR_0659374
    Familial candidiasis 7 (CANDF7)4--see VAR_0659372 C R mis40--------
    VAR_0659384
    Familial candidiasis 7 (CANDF7)4--see VAR_0659382 M I mis40--------
    VAR_0659354
    Familial candidiasis 7 (CANDF7)4--see VAR_0659352 D H mis40--------
    VAR_0659434
    Familial candidiasis 7 (CANDF7)4--see VAR_0659432 R W mis40--------
    VAR_0182654
    STAT1 deficiency complete (STAT1D)4--see VAR_0182652 L P mis40--------

    HapMap Linkage Disequilibrium report for STAT1 (191829084 - 191885686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STAT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834493CNV Gain17160897


    Human Gene Mutation Database (HGMD): STAT1

    Locus Specific Mutation Databases (LSDB): STAT1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600555   
    OMIM disorders: 209950  
    UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224
  • STAT1 deficiency complete (STAT1D) [MIM:613796]: A disorder characterized by susceptibility to severe
    mycobacterial and viral infections. Affected individuals can develop disseminated infections and die of viral
    illness. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers
    predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin
    (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium
    tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to
    mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The
    pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity
    determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like
    lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with
    tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant
    or X-linked inheritance. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Familial candidiasis 7 (CANDF7) [MIM:614162]: A primary immunodeficiency disorder with altered immune
    responses and impaired clearance of fungal infections, selective against Candida. It is characterized by
    persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus
    Candida, mainly Candida albicans. Note=The disease is caused by mutations affecting the gene represented in this
    entry. STAT1 mutations in patients with autosomal dominant candidiasis lead to defective responses of type 1 and
    type 17 helper T-cells, characterized by reduced production of interferon-alpha, interleukin-17, and
    interleukin-22. These cytokines are crucial for the antifungal defense of skin and mucosa (PubMed:21714643)

  • 20/139 diseases for STAT1 (see all 139):    About MalaCards
    human t-cell leukemia virus type 2    candidiasis familial chronic mucocutaneous, autosomal recessive    familial atypical mycobacteriosis, stat1-related    campylobacteriosis
    thanatophoric dysplasia    polyradiculoneuropathy    chronic inflammatory demyelinating polyradiculoneuropathy    mumps
    chronic mucocutaneous candidiasis    parainfluenza virus type 3    venezuelan equine encephalitis    salmonellosis
    pouchitis    cervical squamous cell carcinoma    skeletal dysplasias    measles
    dwarfism    achondroplasia    west nile virus    viral hepatitis

    5 diseases from the University of Copenhagen DISEASES database for STAT1:
    Cancer     Chronic mucocutaneous candidiasis     Hepatitis C     Thanatophoric dysplasia
    Multiple sclerosis

    STAT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for STAT1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thanatophoric dysplasia 59 3 15843401 (1), 9069288 (1), 12624096 (1)
    virus infection 46.4 23 16934001 (2), 12917439 (1), 17182562 (1), 20033640 (1) (see all 18)
    tumors 44.7 124 16449678 (8), 11971185 (6), 17680769 (4), 15668815 (3) (see all 64)
    parainfluenza 44.7 7 15604442 (2), 12504558 (1), 16051811 (1), 17640695 (1) (see all 5)
    fibrosarcoma 42.5 15 12589807 (2), 7539922 (1), 10201928 (1), 11971185 (1) (see all 11)
    inflammation 42 17 18620071 (1), 15947106 (1), 16734720 (1), 19796080 (1) (see all 14)
    necrosis 40.1 12 18492658 (1), 19651857 (1), 12856330 (1), 16735457 (1) (see all 12)
    leukemia 35.1 13 8662645 (1), 9633897 (1), 16799645 (1), 9399961 (1) (see all 12)
    hepatitis c chronic 35 8 14699505 (2), 16162158 (1), 14690454 (1), 16306605 (1) (see all 5)
    dwarfism 34.3 2 9069288 (1), 17561467 (1)

    Genetic Association Database (GAD): STAT1
    Human Genome Epidemiology (HuGE) Navigator: STAT1 (50 documents)

    Export disorders for STAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAT1 gene, integrated from 9 sources (see all 1587):
    (articles sorted by number of sources associating them with STAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (PubMed id 7885841)1, 2, 3, 9 Yan R.... Darnell J.E. Jr. (1995)
    2. Protein kinase Cdelta regulates apoptosis via activation of STAT1. (PubMed id 15322115)1, 2, 9 DeVries T.A....Reyland M.E. (2004)
    3. Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. (PubMed id 16934001)1, 2, 9 Chapgier A....Casanova J.L. (2006)
    4. PIAS proteins promote SUMO-1 conjugation to STAT1. (PubMed id 12855578)1, 2, 9 Ungureanu D.... Silvennoinen O. (2003)
    5. MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. (PubMed id 17897103)1, 2, 9 Vanhatupa S.... Silvennoinen O. (2008)
    6. Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. (PubMed id 12590259)1, 2, 9 Dupuis S.... Casanova J.L. (2003)
    7. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. (PubMed id 9121453)1, 2, 9 Li X....Stark G.R. (1997)
    8. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. (PubMed id 7657660)1, 2, 9 Quelle F.W....Ihle J.N. (1995)
    9. Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy. (PubMed id 20045654)1, 4, 9 Hahn W.H....Kim S.D. (2010)
    10. High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. (PubMed id 19333953)1, 4, 9 Namjou B....Jacob C.O. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6772 HGNC: 11362 AceView: STAT1 Ensembl:ENSG00000115415 euGenes: HUgn6772
    ECgene: STAT1 Kegg: 6772 H-InvDB: STAT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/stat1/
    STAT1basehttp://bioinf.uta.fi/STAT1base/
    Wikipedia http://en.wikipedia.org/wiki/STAT1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STAT1 gene:
    Search GeneIP for patents involving STAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Antibodies for STAT1
     See all of Abcam's Antibodies, Kits and Proteins for STAT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for STAT1




     Proteins for STAT1
     Antibodies for STAT1
     ELISAs for STAT1
     CLIAs for STAT1
     Search LifeMap BioReagents cell lines for STAT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT1
     SwitchGear 3'UTR luciferase reporter plasmids for STAT1
     SwitchGear Promoter luciferase reporter plasmids for STAT1
     ThermoFisher Antibody for STAT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for STAT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAT1
    Customized:
     lentivirus for stable overexpression of STAT1
     lentivirus expression plasmids for stable overexpression of STAT1
     adenovirus for overexpression of STAT1
     LSBio Antibodies in human, mouse, rat for STAT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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