Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STAT1 Gene

protein-coding   GIFtS: 72
GCID: GC02M191829

Signal Transducer And Activator Of Transcription 1, 91kDa

(Previous names: signal transducer and activator of transcription 1, 91kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Signal Transducer And Activator Of Transcription 1, 91kDa1 2     ISGF-32
Transcription Factor ISGF-3 Components P91/P841 2 3     STAT912
CANDF72 5     Signal Transducer And Activator Of Transcription 1-Alpha/Beta2
Signal Transducer And Activator Of Transcription 1, 91kD1     Signal Transducer And Activator Of Transcription-12

External Ids:    HGNC: 113621   Entrez Gene: 67722   Ensembl: ENSG000001154157   OMIM: 6005555   UniProtKB: P422243   

Export aliases for STAT1 gene to outside databases

Previous GC identifers: GC02M190028 GC02M190536 GC02M191797 GC02M192036 GC02M191659 GC02M191542 GC02M183693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for STAT1 Gene:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth
factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or
heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be
activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein
mediates the expression of a variety of genes, which is thought to be important for cell viability in response to
different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAT1 Gene:
STAT1 (signal transducer and activator of transcription 1, 91kDa) is a protein-coding gene. Diseases associated with STAT1 include atypical mycobacteriosis, familial, and mendelian susceptibility to mycobacterial diseases due to partial stat1 deficiency. GO annotations related to this gene include protein homodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224
Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),
cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta)
binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and
JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with
ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN
stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the
cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.
It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN
gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1,
FGFR2, FGFR3 and FGFR4

Gene Wiki entry for STAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the STAT1 gene promoter:
         STAT5B   Max1   AP-1   IRF-1   S8   COMP1   FOXO1a   RSRFC4   c-Myc   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STAT1 promoter sequence
   Search Chromatin IP Primers for STAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2   Ensembl cytogenetic band:  2q32.2   HGNC cytogenetic band: 2q32.2-q32.3

STAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAT1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M191829:  view genomic region     (about GC identifiers)

Start:
191,829,084 bp from pter      End:
191,885,686 bp from pter
Size:
56,603 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224 (See protein sequence)
Recommended Name: Signal transducer and activator of transcription 1-alpha/beta  
Size: 750 amino acids; 87335 Da
Subunit: Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon
IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3
complex (ISGF3) with IRF9. Interacts (phosphorylated at Ser 727) with PIAS1 (dimethylated on arginine); the
interaction results in release of STAT1 from its target gene. Interacts with IFNAR1; the interaction requires the
phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2, NMI, PTK2/FAK1 and SRC. Interacts with ERBB4
(phosphorylated). Interacts with Sendai virus C', C, Y1 and Y2 proteins, Nipah virus P, V and W proteins, and
rabies virus phosphoprotein preventing activation of ISRE and GAS promoter. Interacts with HCV core protein; the
interaction results in STAT1 degradation
3 PDB 3D structures from and Proteopedia for STAT1:
1BF5 (3D)        1YVL (3D)        2KA6 (3D)    
Secondary accessions: A8K989 B2RCA0 D2KFR8 D3DPI7 Q53S88 Q53XW4 Q68D00 Q9UDL5
Alternative splicing: 2 isoforms:  P42224-1   P42224-2   

Explore the universe of human proteins at neXtProt for STAT1: NX_P42224

Explore proteomics data for STAT1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including
    IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent
    translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1,
    JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates
    STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2,
    FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma
    stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though
    increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to
    DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is
    catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates
    interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much
    later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of
    IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive,
    phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-7011
  • Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727,
    and by interaction with PIAS proteins. Enhances the transactivation activity1
  • ISGylated1
  • Ubiquitination2 at Lys592, Lys652
  • Modification sites at PhosphoSitePlus

  • See STAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_009330.1  NP_644671.1  

    ENSEMBL proteins: 
     ENSP00000388240   ENSP00000354394   ENSP00000386244   ENSP00000388772   ENSP00000376136  
     ENSP00000394512   ENSP00000376137   ENSP00000402548   ENSP00000411398   ENSP00000416019  
     ENSP00000438703  
    Reactome Protein details: P42224

    STAT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for STAT1
    OriGene Protein Over-expression Lysate for STAT1
    OriGene MassSpec for STAT1
    OriGene Custom Protein Services for STAT1
    GenScript Custom Purified and Recombinant Proteins Services for STAT1
    Novus Biologicals STAT1 Proteins
    Novus Biologicals STAT1 Lysates
    Sino Biological Recombinant Protein for STAT1
    Sino Biological Cell Lysate for STAT1
    ProSpec Recombinant Protein for STAT1
    Cloud-Clone Corp. Proteins for STAT1

    STAT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT1
    R&D Systems Antibodies for STAT1
    Cell Signaling Technology (CST) Antibodies for STAT1 
    OriGene Antibodies for STAT1
    OriGene Custom Antibody Services for STAT1
    Novus Biologicals STAT1 Antibodies
    Abcam antibodies for STAT1
    Cloud-Clone Corp. Antibodies for STAT1
    ThermoFisher Antibody for STAT1
    LSBio Antibodies in human, mouse, rat for STAT1

    STAT1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of STAT1
    OriGene Custom Assay Services for STAT1
    R&D Systems ELISAs for STAT1
    GenScript Custom Assay Services for STAT1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAT1
    Cloud-Clone Corp. CLIAs for STAT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 10):
     IPR013801 STAT_TF_DNA-bd
     IPR008967 p53-like_TF_DNA-bd
     IPR011992 EF-hand-dom_pair
     IPR013800 STAT_TF_alpha
     IPR022752 STAT1_TAZ2-bd_C

    Graphical View of Domain Structure for InterPro Entry P42224

    ProtoNet protein and cluster: P42224

    1 Blocks protein domain: IPB001217 STAT protein

    UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224
    Similarity: Belongs to the transcription factor STAT family
    Similarity: Contains 1 SH2 domain


    STAT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAT1_HUMAN, P42224
    Function: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),
    cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta)
    binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and
    JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with
    ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN
    stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the
    cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.
    It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN
    gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
    Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1,
    FGFR2, FGFR3 and FGFR4

         Genatlas biochemistry entry for STAT1:
    signal transducer and activator of transcription 1,91kDa,activated during monocyte to macrophage differentiation
    as an early transcription factor initially activated by adherence and then able to modulate the expression of
    functional genes such as ICAM1 and FCGR1

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA18035482
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA--
    GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IDA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IDA9630226
         
    STAT1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for STAT1:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 10 alleles(MGI details for Stat1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  no phenotypic analysis 

    STAT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for STAT1: Stat1tm1.2Mmul Stat1tm1Rds Stat1tm1Dlv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAT1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for STAT1 (see all 308):
    ABCD1,  ACAD11,  ACSM4,  AHCYL1,  AHSA1,  APLNR,  APOL4,  ARHGEF10,  ASB5,  ATF5

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NATTTCCNGGAAAT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAT1:
    hsa-mir-146a-5p (MIRT021229), hsa-mir-34a-5p (MIRT025278), hsa-mir-145-5p (MIRT000626), hsa-mir-615-3p (MIRT040456)

    Block miRNA regulation of human, mouse, rat STAT1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate STAT1:
    hsa-miR-124* hsa-miR-495 hsa-miR-607 hsa-miR-186* hsa-miR-1252 hsa-miR-3182 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSTAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAT1
    Predesigned siRNA for gene silencing in human, mouse, rat STAT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAT1

    Clone
    Products:
         
    OriGene clones in human, mouse for STAT1 (see all 12)
    OriGene ORF clones in mouse, rat for STAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STAT1 (NM_139266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STAT1_HUMAN, P42224: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and
    dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA18035482
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    STAT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STAT1 About   (see all 86)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-7 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-9 Pathway0.36
    2Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    3Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    EPO Receptor Signaling0.42
    4Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    Immune response IL 10 signaling pathway0.38
    Development PDGF signaling via STATs and NF kB0.41
    IL23-mediated signaling events0.38
    Development Angiopoietin Tie2 signaling0.38
    5Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for STAT1 (see all 7)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-9 Signaling Pathways
    Th1 Differentiation
    IL-7 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for STAT1 (see all 28)
        FLT3 Signaling
    MAPK Signaling
    BRCA1 Pathway
    Interferon Pathway
    PDGF Pathway

    1 Cell Signaling Technology (CST) Pathway for STAT1
        Jak/Stat Pathway

    1 Tocris Bioscience Pathway for STAT1
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for STAT1 (see all 19)
        Immune response Bacterial infections in normal airways
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for STAT1 (see all 49)
        TGF Beta Signaling Pathway
    EGFR1 Signaling Pathway
    Adipogenesis
    p38 MAPK Signaling Pathway
    EPO Receptor Signaling

    1 Sino Biological Pathway for STAT1
        EGFR Signaling Pathway

    Selected Reactome Pathways for STAT1 (see all 10)
        Regulation of IFNA signaling
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Regulation of IFNG signaling
    Downstream signal transduction

    1 PharmGKB Pathway for STAT1
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for STAT1) (see all 17):
        Chemokine signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    Jak-STAT signaling pathway
    Prolactin signaling pathway


    STAT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT1 (see all 22): 
              Lung Cancer in human mouse rat
              HIV Host Response in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Antiviral Response in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAT1 (P422241, 2, 3 ENSP000003543944) via UniProtKB, MINT, STRING, and/or I2D (see all 254)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1057697,EBI-641062 MINT-74754 MINT-74755 I2D: score=2 STRING: ENSP00000269571
    IL6STP401892, 3, ENSP000003387994MINT-8030726 MINT-8028344 MINT-8028329 I2D: score=1 STRING: ENSP00000338799
    STAT1P422241, 2EBI-1057697,EBI-1057697 MINT-8030248 MINT-8030173 MINT-8030158 MINT-8030188
    EGFRP005332, 3, ENSP000002754934MINT-8026146 MINT-8026130 I2D: score=5 STRING: ENSP00000275493
    STAT3P407632, 3, ENSP000002646574MINT-8034934 MINT-8034919 I2D: score=5 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001937negative regulation of endothelial cell proliferation IMP16585190
    GO:0002053positive regulation of mesenchymal cell proliferation ISS--
    GO:0003340negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS--
    GO:0006351transcription, DNA-templated ----

    STAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for STAT1
    5 ApexBio Compounds for STAT1     About this table
    CompoundAction CAS #
    FludarabineChemotherapy agent[21679-14-1]
    NSC 74859STAT3 inhibitor, binds to STAT3 SH2 domain, inhibits STAT3-DNA binding[501919-59-1]
    SD 1008JAK2/STAT3 signaling pathway inhibitor[960201-81-4]
    StatticSmall molecule inhibitor of STAT3[19983-44-9]
    WP1066Cell permeable STAT3 inhibitor[857064-38-1]

    Browse Tocris compounds for STAT1

    Selected Novoseek inferred chemical compound relationships for STAT1 gene (see all 102)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ifn-alpha 81.5 66 9804758 (5), 12967644 (3), 16169484 (3), 9576923 (2) (see all 35)
    tyrosine 81 490 7591091 (5), 8780896 (5), 9344858 (4), 18591661 (4) (see all 99)
    gp 130 76.9 33 8662591 (4), 8662795 (3), 18431520 (2), 18292512 (2) (see all 21)
    2',5'-oligoadenylate 71.1 6 20014458 (1), 16297951 (1), 19407486 (1), 11316742 (1) (see all 6)
    serine 57.3 149 10940874 (5), 9399961 (4), 12018856 (4), 11839738 (3) (see all 70)
    cgp77675 56.2 2 11840778 (1), 14521054 (1)
    15-deoxy-delta-12,14-prostaglandin j2 49.8 18 12517740 (4), 12847270 (3), 11971025 (1), 12584205 (1) (see all 6)
    piceatannol 48.7 8 10777558 (2), 18664717 (2), 15022320 (1), 19796718 (1) (see all 6)
    sam 486a 47.7 1 15547724 (1)
    ly294002 47.4 12 15728510 (2), 12807916 (2), 15994321 (1), 19103208 (1) (see all 5)



    STAT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STAT1 gene (2 alternative transcripts): 
    NM_007315.3  NM_139266.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415035 ENST00000361099(uc021vue.1 uc010fse.2 uc002usj.2 uc010fsf.1)
    ENST00000409465 ENST00000423282 ENST00000392322(uc002usk.2) ENST00000452281
    ENST00000392323(uc002usl.2) ENST00000464072 ENST00000424722 ENST00000454414
    ENST00000432058 ENST00000540176
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STAT1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate STAT1:
    hsa-miR-124* hsa-miR-495 hsa-miR-607 hsa-miR-186* hsa-miR-1252 hsa-miR-3182 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSTAT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAT1
    Predesigned siRNA for gene silencing in human, mouse, rat STAT1
    Clone
    Products:
         
    OriGene clones in human, mouse for STAT1 (see all 12)
    OriGene ORF clones in mouse, rat for STAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): STAT1 (NM_139266)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT1
      QuantiTect SYBR Green Assays in human, mouse, rat STAT1
      QuantiFast Probe-based Assays in human, mouse, rat STAT1

    Selected AceView cDNA sequences (see all 557):

    N34420 BM917131 CB216794 AI273207 CR618286 AI470989 AI859876 BQ441149 
    CB158922 AI610730 AA488075 AW317081 AI589026 BM726325 BE891509 BQ219209 
    BG252684 BI092633 BX490196 BM856100 BF942207 AI262969 AU122512 T29152 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STAT1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                                                                                                                                                            
    SP2:                                      -                                                                                                                     
    SP3:                                      -                                                                                                                     
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
    SP1:              -                       -                                       
    SP2:              -                       -                       -               
    SP3:              -                       -                                       
    SP4:                                                                              
    SP5:              -                                                               


    ECgene alternative splicing isoforms for STAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STAT1 expression in normal human tissues (normalized intensities)      STAT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATGCTGT
    STAT1 Expression
    About this image


    STAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Brain (Nervous System)
             Cerebral Cortex
    STAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAT1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including STAT1 (see all 22): 
              Lung Cancer in human mouse rat
              HIV Host Response in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Antiviral Response in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for STAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for STAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT1
    QuantiTect SYBR Green Assays in human, mouse, rat STAT1
    QuantiFast Probe-based Assays in human, mouse, rat STAT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for STAT1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stat11 , 5 signal transducer and activator of transcription 11, 5 86.74(n)1
    93.59(a)1
      1 (26.81 cM)5
    208461  NM_001205313.11  NP_001192242.11 
     521194385 
    chicken
    (Gallus gallus)
    Aves STAT11 signal transducer and activator of transcription 1, more 76.24(n)
    84.3(a)
      424044  NM_001012914.1  NP_001012932.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAT16
    signal transducer and activator of transcription 1...
    42(a)
    1 ↔ 1
    2(134110585-134219572)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983242 Stat1 76.56(n)    AY101602.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stat12 signal transduction and activation of transcription more 75.46(n)   30768  BC060933.1 


    ENSEMBL Gene Tree for STAT1 (if available)
    TreeFam Gene Tree for STAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STAT1 gene
    STAT5B2  STAT42  STAT22  STAT32  STAT62  STAT5A2  
    7 SIMAP similar genes for STAT1 using alignment to 10 protein entries:     STAT1_HUMAN (see all proteins):
    STAT4    STAT3    Stat2    STAT2    DKFZp686H05229    STAT5A
    STAT5B

    STAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STAT1 (see all 1154)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659414
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659412 Q P mis40--------
    VAR_0360014
    A breast cancer sample4--see VAR_0360012 P A mis40--------
    VAR_0659364
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659362 Y N mis40--------
    VAR_0658174
    Mendelian susceptibility to mycobacterial disease (MSMD)4--see VAR_0658172 Q H mis40--------
    VAR_0659404
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659402 A V mis40--------
    VAR_0659374
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659372 C R mis40--------
    VAR_0659384
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659382 M I mis40--------
    VAR_0659354
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659352 D H mis40--------
    VAR_0659434
    Candidiasis, familial, 7 (CANDF7)4--see VAR_0659432 R W mis40--------
    VAR_0182654
    STAT1 deficiency complete (STAT1D)4--see VAR_0182652 L P mis40--------

    HapMap Linkage Disequilibrium report for STAT1 (191829084 - 191885686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for STAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834493CNV Gain17160897

    Human Gene Mutation Database (HGMD): STAT1
    Locus Specific Mutation Databases (LSDB): STAT1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for STAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600555   
    OMIM disorders: 209950  613796  614162  
    UniProtKB/Swiss-Prot: STAT1_HUMAN, P42224
  • STAT1 deficiency complete (STAT1D) [MIM:613796]: A disorder characterized by susceptibility to severe
    mycobacterial and viral infections. Affected individuals can develop disseminated infections and die of viral
    illness. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers
    predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin
    (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium
    tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to
    mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The
    pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity
    determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like
    lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with
    tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant
    or X-linked inheritance. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Candidiasis, familial, 7 (CANDF7) [MIM:614162]: A primary immunodeficiency disorder with altered immune
    responses and impaired clearance of fungal infections, selective against Candida. It is characterized by
    persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus
    Candida, mainly Candida albicans. Note=The disease is caused by mutations affecting the gene represented in this
    entry. STAT1 mutations in patients with autosomal dominant candidiasis lead to defective responses of type 1 and
    type 17 helper T-cells, characterized by reduced production of interferon-alpha, interleukin-17, and
    interleukin-22. These cytokines are crucial for the antifungal defense of skin and mucosa (PubMed:21714643)

  • Selected diseases for STAT1 (see all 159):    About MalaCards
    atypical mycobacteriosis, familial    mendelian susceptibility to mycobacterial diseases due to partial stat1 deficiency    mycobacterial and viral infections autosomal recessive    candidiasis, familial, 7
    familial atypical mycobacteriosis, stat1-related    campylobacteriosis    candidiasis familial chronic mucocutaneous, autosomal recessive    thanatophoric dysplasia
    human t-cell leukemia virus type 2    mumps    polyradiculoneuropathy    chronic inflammatory demyelinating polyradiculoneuropathy
    candidiasis, familial, 2, autosomal recessive    candidiasis    chronic mucocutaneous candidiasis    parainfluenza virus type 3
    venezuelan equine encephalitis    coccidioidomycosis    pouchitis    fanconi anemia, complementation group c

    5 diseases from the University of Copenhagen DISEASES database for STAT1:
    Cancer     Chronic mucocutaneous candidiasis     Hepatitis C     Thanatophoric dysplasia
    Multiple sclerosis

    STAT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for STAT1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thanatophoric dysplasia 59 3 15843401 (1), 9069288 (1), 12624096 (1)
    virus infection 46.4 23 16934001 (2), 12917439 (1), 17182562 (1), 20033640 (1) (see all 18)
    tumors 44.7 124 16449678 (8), 11971185 (6), 17680769 (4), 15668815 (3) (see all 64)
    parainfluenza 44.7 7 15604442 (2), 12504558 (1), 16051811 (1), 17640695 (1) (see all 5)
    fibrosarcoma 42.5 15 12589807 (2), 7539922 (1), 10201928 (1), 11971185 (1) (see all 11)
    inflammation 42 17 18620071 (1), 15947106 (1), 16734720 (1), 19796080 (1) (see all 14)
    necrosis 40.1 12 18492658 (1), 19651857 (1), 12856330 (1), 16735457 (1) (see all 12)
    leukemia 35.1 13 8662645 (1), 9633897 (1), 16799645 (1), 9399961 (1) (see all 12)
    hepatitis c chronic 35 8 14699505 (2), 16162158 (1), 14690454 (1), 16306605 (1) (see all 5)
    dwarfism 34.3 2 9069288 (1), 17561467 (1)

    Genetic Association Database (GAD): STAT1
    Human Genome Epidemiology (HuGE) Navigator: STAT1 (50 documents)

    Export disorders for STAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STAT1 gene, integrated from 10 sources (see all 1611):
    (articles sorted by number of sources associating them with STAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (PubMed id 7885841)1, 2, 3, 9 Yan R.... Darnell J.E. Jr. (Nucleic Acids Res. 1995)
    2. Protein kinase Cdelta regulates apoptosis via activation of STAT1. (PubMed id 15322115)1, 2, 9 DeVries T.A.... Reyland M.E. (J. Biol. Chem. 2004)
    3. Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. (PubMed id 16934001)1, 2, 9 Chapgier A.... Casanova J.L. (PLoS Genet. 2006)
    4. PIAS proteins promote SUMO-1 conjugation to STAT1. (PubMed id 12855578)1, 2, 9 Ungureanu D.... Silvennoinen O. (Blood 2003)
    5. MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. (PubMed id 17897103)1, 2, 9 Vanhatupa S.... Silvennoinen O. (Biochem. J. 2008)
    6. Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. (PubMed id 12590259)1, 2, 9 Dupuis S.... Casanova J.L. (Nat. Genet. 2003)
    7. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. (PubMed id 9121453)1, 2, 9 Li X.... Stark G.R. (Mol. Cell. Biol. 1997)
    8. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. (PubMed id 7657660)1, 2, 9 Quelle F.W....Ihle J.N. (J. Biol. Chem. 1995)
    9. Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy. (PubMed id 20045654)1, 4, 9 Hahn W.H....Kim S.D. (Cytokine 2010)
    10. High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. (PubMed id 19333953)1, 4, 9 Namjou B....Jacob C.O. (Arthritis Rheum. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6772 HGNC: 11362 AceView: STAT1 Ensembl:ENSG00000115415 euGenes: HUgn6772
    ECgene: STAT1 Kegg: 6772 H-InvDB: STAT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STAT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STAT1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/stat1/
    STAT1basehttp://bioinf.uta.fi/STAT1base/
    Wikipedia http://en.wikipedia.org/wiki/STAT1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STAT1 gene:
    Search GeneIP for patents involving STAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of STAT1
     EMD Millipore Mono- and Polyclonal Antibodies for the study of STAT1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for STAT1 (STAT1)   Browse Cell Culture Products  
     ELISAs for STAT1 (STAT1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STAT1   OriGene RNAi products in human, mouse, rat for STAT1  
     OriGene qPCR primer pairs and template standards for STAT1   OriGene Protein Over-expression Lysate for STAT1  
     OriGene MassSpec something-or-other for STAT1   OriGene clones in human, mouse for STAT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for STAT1   OriGene Purified Protein for STAT1  
     OriGene ORF clones in mouse, rat for STAT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STAT1   OriGene Custom Protein Services for STAT1  

     
     
     Block miRNA regulation of human, mouse, rat STAT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STAT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAT1 Predesigned siRNA for gene silencing in human, mouse, rat STAT1
     QuantiFast Probe-based Assays in human, mouse, rat STAT1 QuantiTect SYBR Green Assays in human, mouse, rat STAT1
     PCR Arrays including human, mouse, rat STAT1 Search Chromatin IP Primers for STAT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAT1  GeneGlobe Interaction Network for STAT1
     Regulatory tfbs in STAT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for STAT1 GenScript cDNA clones with any tag delivered in your preferred vector for STAT1
     GenScript Custom Assay Services for STAT1 GenScript Custom overexpressing Cell Line Services for STAT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for STAT1 

     Search Tocris compounds for STAT1
     Proteins for STAT1
     Cell Lysates for STAT1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for STAT1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STAT1 antibodies
     STAT1 proteins
     STAT1 lysates
     Antibodies for STAT1
     See all of Abcam's Antibodies, Kits and Proteins for STAT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for STAT1
     Proteins for STAT1
     Antibodies for STAT1
     ELISAs for STAT1
     CLIAs for STAT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for STAT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAT1
     SwitchGear 3'UTR luciferase reporter plasmids for STAT1
     SwitchGear Promoter luciferase reporter plasmids for STAT1
     ThermoFisher Antibody for STAT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAT1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAT1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAT1
     LSBio Antibodies in human, mouse, rat for STAT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for STAT1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STAT1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4