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Aliases for STARD9 Gene

Aliases for STARD9 Gene

  • StAR Related Lipid Transfer Domain Containing 9 2 3 5
  • START Domain-Containing Protein 9 3 4
  • START Domain Containing 9 2 3
  • StAR-Related Lipid Transfer (START) Domain Containing 9 3
  • StAR-Related Lipid Transfer Protein 9 3
  • KIAA1300 4
  • KIF16A 3
  • StARD9 4

External Ids for STARD9 Gene

Previous GeneCards Identifiers for STARD9 Gene

  • GC15P038350
  • GC15P035878
  • GC15P040561
  • GC15P040590
  • GC15P040692
  • GC15P040661
  • GC15P040714
  • GC15P042867
  • GC15P019716

Summaries for STARD9 Gene

GeneCards Summary for STARD9 Gene

STARD9 (StAR Related Lipid Transfer Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and lipid binding. An important paralog of this gene is KIF16B.

UniProtKB/Swiss-Prot for STARD9 Gene

  • Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD9 Gene

Genomics for STARD9 Gene

Regulatory Elements for STARD9 Gene

Enhancers for STARD9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F042607 1 Ensembl ENCODE 12.3 +33.0 32967 2.4 HDGF MTA2 TAL1 BHLHE40 MAX EBF1 EP300 ARID1B NCOR1 EED STARD9 HAUS2 LRRC57 EIF4EBP2P2 PIR61026
GH15F042604 1 Ensembl ENCODE 12.3 +30.2 30244 2.6 PKNOX1 WRNIP1 MAX EBF1 ZBTB40 RELA FOXK2 ZNF362 MTA2 ZEB2 LRRC57 STARD9 HAUS2 EIF4EBP2P2 PIR61026
GH15F042619 0.5 ENCODE 13 +44.1 44103 1.1 RAD51 ZBTB33 FEZF1 STARD9 HAUS2 LRRC57 SNAP23 GANC TMEM87A EIF4EBP2P2 PIR61026
GH15F042583 1.1 Ensembl ENCODE 5.2 +8.6 8578 1.2 HDAC1 PKNOX1 TBL1XR1 GATA2 ETV6 CREM ZBTB2 NCOA1 ZEB2 KLF16 LRRC57 HAUS2 CAPN3 STARD9 ADAL EIF4EBP2P2 PIR61026
GH15F042860 0.3 FANTOM5 3.2 +284.8 284836 0.4 TTBK2 STARD9 KRT8P50
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STARD9 on UCSC Golden Path with GeneCards custom track

Promoters for STARD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001451744 166 2001 HDGF ATF1 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48

Genomic Location for STARD9 Gene

Chromosome:
15
Start:
42,575,634 bp from pter
End:
42,720,998 bp from pter
Size:
145,365 bases
Orientation:
Plus strand

Genomic View for STARD9 Gene

Genes around STARD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD9 Gene

Proteins for STARD9 Gene

  • Protein details for STARD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2P6-STAR9_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 9
    Protein Accession:
    Q9P2P6
    Secondary Accessions:
    • Q68DG2
    • Q6AI01
    • Q6ZWK0
    • Q9UF70

    Protein attributes for STARD9 Gene

    Size:
    4700 amino acids
    Molecular mass:
    516343 Da
    Quaternary structure:
    • Interacts with ATAD3A.
    SequenceCaution:
    • Sequence=CAH18258.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18258.1; Type=Erroneous termination; Positions=2903; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for STARD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD9 Gene

Post-translational modifications for STARD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD9 Gene

Domains & Families for STARD9 Gene

Suggested Antigen Peptide Sequences for STARD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2P6

UniProtKB/Swiss-Prot:

STAR9_HUMAN :
  • Contains 1 FHA domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
  • Contains 1 START domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with STARD9: view

Function for STARD9 Gene

Molecular function for STARD9 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).

Gene Ontology (GO) - Molecular Function for STARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA,IDA 22153075
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IDA 22153075
GO:0008289 lipid binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with STARD9: view

Phenotypes for STARD9 Gene

GenomeRNAi human phenotypes for STARD9:
genes like me logo Genes that share phenotypes with STARD9: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STARD9 Gene

Localization for STARD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD9 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD9 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for STARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22153075
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 22153075
GO:0005794 Golgi apparatus IDA --
GO:0005814 centriole IEA,IDA 22153075
genes like me logo Genes that share ontologies with STARD9: view

Pathways & Interactions for STARD9 Gene

SuperPathways for STARD9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,IBA --
GO:0008152 metabolic process IDA 22153075
GO:0030705 cytoskeleton-dependent intracellular transport IBA --
GO:0051225 spindle assembly IMP 22153075
genes like me logo Genes that share ontologies with STARD9: view

No data available for Pathways by source and SIGNOR curated interactions for STARD9 Gene

Transcripts for STARD9 Gene

mRNA/cDNA for STARD9 Gene

(15) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STARD9 Gene

StAR-related lipid transfer (START) domain containing 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD9 Gene

No ASD Table

Relevant External Links for STARD9 Gene

GeneLoc Exon Structure for
STARD9
ECgene alternative splicing isoforms for
STARD9

Expression for STARD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STARD9 Gene

Protein differential expression in normal tissues from HIPED for STARD9 Gene

This gene is overexpressed in Lung (16.6), Pancreas (13.5), Fetal gut (10.6), and Colon muscle (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STARD9 Gene



NURSA nuclear receptor signaling pathways regulating expression of STARD9 Gene:

STARD9

SOURCE GeneReport for Unigene cluster for STARD9 Gene:

Hs.122061

mRNA Expression by UniProt/SwissProt for STARD9 Gene:

Q9P2P6-STAR9_HUMAN
Tissue specificity: Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas, prostate and lung.
genes like me logo Genes that share expression patterns with STARD9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for STARD9 Gene

Orthologs for STARD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD9 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia STARD9 34 35
  • 80.16 (n)
cow
(Bos Taurus)
Mammalia STARD9 34
  • 75.95 (n)
-- 35
  • 65 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Stard9 34 16 35
  • 73.73 (n)
oppossum
(Monodelphis domestica)
Mammalia STARD9 35
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves STARD9 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD9 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stard9 35
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-104 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-104 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for STARD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STARD9 Gene

ENSEMBL:
Gene Tree for STARD9 (if available)
TreeFam:
Gene Tree for STARD9 (if available)

Paralogs for STARD9 Gene

Paralogs for STARD9 Gene

(8) SIMAP similar genes for STARD9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STARD9: view

Variants for STARD9 Gene

Sequence variations from dbSNP and Humsavar for STARD9 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152932 -- 42,649,003(+) agtag(C/G)tgaga intron-variant
rs10162619 -- 42,587,488(+) TCCAC(G/T)GAGTC intron-variant
rs10162744 -- 42,587,185(+) AAGGA(A/C)CAACA intron-variant
rs10162939 -- 42,638,579(+) GATCA(A/T)TGCCT intron-variant, upstream-variant-2KB
rs10163044 -- 42,611,258(+) agatg(C/G)agttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD9 Gene

Variant ID Type Subtype PubMed ID
nsv984060 CNV duplication 23825009
nsv976927 CNV duplication 23825009
nsv952615 CNV deletion 24416366
nsv569238 CNV loss 21841781
nsv528725 CNV gain 19592680
nsv517553 CNV gain+loss 19592680
nsv475437 CNV novel sequence insertion 20440878
nsv457122 CNV loss 19166990
nsv1509 CNV insertion 18451855
nsv1160288 CNV deletion 26073780
esv3892679 CNV loss 25118596
esv3636280 CNV loss 21293372
esv3636278 CNV loss 21293372
esv3325908 CNV duplication 20981092
esv2763096 CNV loss 21179565
esv2749624 CNV deletion 23290073
esv2662746 CNV deletion 23128226
esv2657104 CNV deletion 23128226
esv25347 CNV loss 19812545
esv1651282 CNV insertion 17803354

Variation tolerance for STARD9 Gene

Gene Damage Index Score: 14.35; 96.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD9 Gene

Human Gene Mutation Database (HGMD)
STARD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD9 Gene

Disorders for STARD9 Gene

Relevant External Links for STARD9

Genetic Association Database (GAD)
STARD9
Human Genome Epidemiology (HuGE) Navigator
STARD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD9

No disorders were found for STARD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD9 Gene

Publications for STARD9 Gene

  1. Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods. (PMID: 16964419) Halama N. … Jager D. (Int. J. Mol. Med. 2006) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. (PMID: 22153075) Torres J.Z. … Jackson P.K. (Cell 2011) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64

Products for STARD9 Gene

Sources for STARD9 Gene

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