STARD9 Gene
protein-coding GIFtS: 46
GCID: GC15P042867
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StAR-related lipid transfer (START) domain containing 9(Previous name: START domain containing 9 )
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Aliases
for STARD9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| StAR-Related Lipid Transfer (START) Domain Containing 91 2 | | START Domain Containing 91 2 | | KIAA13001 3 | | START Domain-Containing Protein 92 3 | | StAR-Related Lipid Transfer Protein 92 | | StARD93 |
| External Ids: | HGNC: 191621 | Entrez Gene: 575192 | Ensembl: ENSG000001594337 | OMIM: 6146425 | UniProtKB: Q9P2P63 |
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| | ORGUL members: | |
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| NONCODE:n382508 n382509 | |
Export aliases for STARD9 gene to outside databasesPrevious GC identifers: GC15P038350 GC15P035878 GC15P040561 GC15P040590 GC15P040692 GC15P040661 GC15P040714 GC15P019716
Summaries
for STARD9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STAR9_HUMAN, Q9P2P6Function: Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilizethe pericentriolar material (PCM)
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Genomic Views
for STARD9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STARD9 gene promoter:
Max1 HOXA9 HOXA9B FOXF2 LCR-F1 Meis-1b E2F-1 E2F c-Myc Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STARD9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STARD9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q14STARD9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P042867: view genomic region
(about GC identifiers)
Start:
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42,867,857 bp from pter |
End:
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43,013,196 bp from pter |
Size:
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145,340 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
42867856 42916576 42965295 chr15
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Proteins
for STARD9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAR9_HUMAN, Q9P2P6 (See
protein sequence)Recommended Name: StAR-related lipid transfer protein 9 Size: 4700 amino acids; 516343 Da
Subunit: Interacts with ATAD3A
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Nucleus. Note=Localizes throughout the cytoplasmand nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis
Sequence caution: Sequence=CAH18258.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH18258.1; Type=Erroneous termination; Positions=2903; Note=Translated as Gln;
Secondary accessions: Q68DG2 Q6AI01 Q6ZWK0 Q9UF70Alternative splicing: 3 isoforms: Q9P2P6-1 Q9P2P6-2 Q9P2P6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for STARD9: NX_Q9P2P6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2P6
STARD9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065810.2
ENSEMBL proteins: ENSP00000290607 ENSP00000454594 ENSP00000454648
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
STARD9 for ontologies About GeneDecksing
STARD9 Antibody Products:
Assay Products for STARD9: |
Protein
Domains /
Families
for STARD9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STARD9 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9P2P6ProtoNet protein and cluster: Q9P2P6 1 Blocks protein family: IPB002913 Lipid-binding START
UniProtKB/Swiss-Prot: STAR9_HUMAN, Q9P2P6Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 FHA domainSimilarity: Contains 1 kinesin-motor domainSimilarity: Contains 1 START domain |
Function
for STARD9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STAR9_HUMAN, Q9P2P6Function: Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilizethe pericentriolar material (PCM)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD9 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
STARD9 for ontologies About GeneDecksing
|
Pathways & Interactions
for STARD9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STARD9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/8 Interacting proteins for STARD9 (Q9P2P62, 3 ENSP000002906074) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
STARD9 for ontologies About GeneDecksing
|
Drugs & Compounds
for STARD9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STARD9
Search CenterWatch for drugs/clinical trials and news about STARD9 / STAR9 
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Transcripts
for STARD9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STARD9 gene (2 alternative transcripts): NM_020759.2 NM_032381.1 Unigene Cluster for STARD9: StAR-related lipid transfer (START) domain containing 9 Hs.122061 [show with all ESTs]Unigene Representative Sequence: NM_0207597 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000564158 ENST00000290607(uc010udj.2 uc010bcw.3) ENST00000563872
ENST00000568493 ENST00000569419 ENST00000562139 ENST00000562619
Additional cDNA sequence: AB037721.1 AK025589.1 AK122666.1 AK124695.1 AK297603.1 AL133579.1 BX648326.1 CR627426.1 CR749416.1 CR936665.1 13 DOTS entries: DT.121018973 DT.100746854 DT.101967974 DT.95263959 DT.101961066 DT.113144 DT.101963523 DT.121068419 DT.91707017 DT.95262157 DT.121018971 DT.121068427 DT.91961079 2 AceView cDNA sequences: AK025589 BX645665
GeneLoc Exon Structure
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Expression
for STARD9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STARD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STARD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STARD9
SOURCE GeneReport for Unigene cluster: Hs.122061
UniProtKB/Swiss-Prot: STAR9_HUMAN, Q9P2P6Tissue specificity: Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas,prostate and lung
SABiosciences Custom PCR Arrays for STARD9
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STARD9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STARD9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD9 |
Orthologs
for STARD9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STARD9 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1BZ58_CHICK6 |
Uncharacterized protein |
53(a) |
1 ↔ 1 |
5(27912992-27991506) |
lizard
(Anolis carolinensis) |
Reptilia |
STARD96 |
-- |
30(a) |
1 ↔ 1 |
1(39700213-39803463) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1001495551 |
stAR-related lipid transfer protein 9-like |
53.93(n)
47.28(a) |
|
100149555 XM_001921870.3 XP_001921905.3 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
52(a) |
1 ↔ 1 |
Group5.19(153234-172377) |
worm
(Caenorhabditis elegans) |
Secernentea |
klp-196 |
Kinesin-Like Protein family member (klp-19) |
15(a) |
possible ortholog |
III(13302642-13307158) |
ENSEMBL Gene Tree for STARD9 (if available)
TreeFam Gene Tree for STARD9 (if available) |
Paralogs
for STARD9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for STARD9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STARD9 (42867857 - 43013196 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for STARD9
6 CNVs: 87662 66779 87661 87660 76956 49555 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STARD9 |
|
Disorders
/ Diseases
for STARD9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STARD9 for disorders About GeneDecksing
OMIM gene information: 614642
OMIM disorders: --
4  diseases for STARD9: About MalaCardslimb-girdle muscular dystrophy muscular dystrophy malaria prostatitis
Human Genome Epidemiology (HuGE) Navigator: STARD9 (3 documents)
Export disorders for STARD9 gene to outside databases
|
Publications
for STARD9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STARD9 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with STARD9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods. (PubMed id 16964419)1, 2, 9 Halama N.... Jager D. (2006)
- The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. (PubMed id 22153075)1, 2 Torres J.Z.... Jackson P.K. (2011)
- Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. (PubMed id 22453275)2 He J....Holt I.J. (2012)
- Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)1 Smith T.C....Luna E.J. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1 Melzer D....Ferrucci L. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
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External Searches for STARD9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing STARD9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STARD9 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing STARD9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STARD9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STARD9 gene:
Search GeneIP for patents involving STARD9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STARD9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STARD9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STARD9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STARD9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STARD9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STARD9 |
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 |  |  |  | |
| | | | Search Tocris compounds for STARD9 |
| |  |  |  |  | | | | |
 |
 |
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 | | | STARD9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD9 |
|  |  |  | | | | Search ThermoFisher Antibodies for STARD9 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat STARD9 |
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