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Aliases for STARD9 Gene

Aliases for STARD9 Gene

  • StAR Related Lipid Transfer Domain Containing 9 2 3 5
  • START Domain-Containing Protein 9 3 4
  • START Domain Containing 9 2 3
  • StAR-Related Lipid Transfer (START) Domain Containing 9 3
  • StAR-Related Lipid Transfer Domain Containing 9 3
  • KIAA1300 4
  • KIF16A 3
  • StARD9 4

External Ids for STARD9 Gene

Previous GeneCards Identifiers for STARD9 Gene

  • GC15P038350
  • GC15P035878
  • GC15P040561
  • GC15P040590
  • GC15P040692
  • GC15P040661
  • GC15P040714
  • GC15P042867
  • GC15P019716

Summaries for STARD9 Gene

GeneCards Summary for STARD9 Gene

STARD9 (StAR Related Lipid Transfer Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and lipid binding.

UniProtKB/Swiss-Prot for STARD9 Gene

  • Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD9 Gene

Genomics for STARD9 Gene

Regulatory Elements for STARD9 Gene

Promoters for STARD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STARD9 on UCSC Golden Path with GeneCards custom track

Genomic Location for STARD9 Gene

Chromosome:
15
Start:
42,575,634 bp from pter
End:
42,720,998 bp from pter
Size:
145,365 bases
Orientation:
Plus strand

Genomic View for STARD9 Gene

Genes around STARD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD9 Gene

Proteins for STARD9 Gene

  • Protein details for STARD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2P6-STAR9_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 9
    Protein Accession:
    Q9P2P6
    Secondary Accessions:
    • Q68DG2
    • Q6AI01
    • Q6ZWK0
    • Q9UF70

    Protein attributes for STARD9 Gene

    Size:
    4700 amino acids
    Molecular mass:
    516343 Da
    Quaternary structure:
    • Interacts with ATAD3A.
    SequenceCaution:
    • Sequence=CAH18258.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18258.1; Type=Erroneous termination; Positions=2903; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for STARD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD9 Gene

Proteomics data for STARD9 Gene at MOPED

Post-translational modifications for STARD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD9 Gene

Domains & Families for STARD9 Gene

Suggested Antigen Peptide Sequences for STARD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2P6

UniProtKB/Swiss-Prot:

STAR9_HUMAN :
  • Contains 1 FHA domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
  • Contains 1 START domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with STARD9: view

Function for STARD9 Gene

Molecular function for STARD9 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).

Gene Ontology (GO) - Molecular Function for STARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008289 lipid binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with STARD9: view

Phenotypes for STARD9 Gene

GenomeRNAi human phenotypes for STARD9:
genes like me logo Genes that share phenotypes with STARD9: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STARD9 Gene

Localization for STARD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD9 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD9 Gene COMPARTMENTS Subcellular localization image for STARD9 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for STARD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22153075
GO:0005737 cytoplasm IDA 22153075
genes like me logo Genes that share ontologies with STARD9: view

Pathways & Interactions for STARD9 Gene

SuperPathways for STARD9 Gene

No Data Available

Interacting Proteins for STARD9 Gene

Gene Ontology (GO) - Biological Process for STARD9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STARD9 Gene

Drugs & Compounds for STARD9 Gene

No Compound Related Data Available

Transcripts for STARD9 Gene

mRNA/cDNA for STARD9 Gene

(11) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STARD9 Gene

StAR-related lipid transfer (START) domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD9 Gene

No ASD Table

Relevant External Links for STARD9 Gene

GeneLoc Exon Structure for
STARD9
ECgene alternative splicing isoforms for
STARD9

Expression for STARD9 Gene

mRNA expression in normal human tissues for STARD9 Gene

Protein differential expression in normal tissues from HIPED for STARD9 Gene

This gene is overexpressed in Lung (16.6), Pancreas (13.5), Fetal gut (10.6), and Colon muscle (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STARD9 Gene



SOURCE GeneReport for Unigene cluster for STARD9 Gene Hs.122061

mRNA Expression by UniProt/SwissProt for STARD9 Gene

Q9P2P6-STAR9_HUMAN
Tissue specificity: Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas, prostate and lung.
genes like me logo Genes that share expression patterns with STARD9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for STARD9 Gene

Orthologs for STARD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD9 35
  • 75.95 (n)
  • 63.27 (a)
-- 36
  • 63 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia STARD9 35
  • 80.16 (n)
  • 68.88 (a)
STARD9 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard9 35
  • 73.73 (n)
  • 60.94 (a)
Stard9 16
Stard9 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD9 35
  • 99.29 (n)
  • 98.72 (a)
STARD9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STARD9 36
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves STARD9 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD9 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stard9 36
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-104 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-104 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for STARD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STARD9 Gene

ENSEMBL:
Gene Tree for STARD9 (if available)
TreeFam:
Gene Tree for STARD9 (if available)

Paralogs for STARD9 Gene

(8) SIMAP similar genes for STARD9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STARD9: view

No data available for Paralogs for STARD9 Gene

Variants for STARD9 Gene

Sequence variations from dbSNP and Humsavar for STARD9 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs12594837 -, - 42,685,092(+) ACAAC(C/T)GTGGC nc-transcript-variant, reference, missense
rs7161810 - 42,686,737(+) CCTTC(C/T)TTCAG nc-transcript-variant, reference, missense
rs16957055 - 42,688,192(+) GAAAG(C/T)ATTGG nc-transcript-variant, reference, missense
rs8030587 - 42,689,608(+) GAAAC(A/G)TCGTA nc-transcript-variant, reference, missense
rs8031218 - 42,690,142(+) AGATA(C/T)CATTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STARD9 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV Gain 19592680
esv2749624 CNV Deletion 23290073
nsv1509 CNV Insertion 18451855
esv2657104 CNV Deletion 23128226
nsv457122 CNV Loss 19166990
nsv517553 CNV Gain+Loss 19592680
esv2662746 CNV Deletion 23128226
esv25347 CNV Loss 19812545
esv1651282 CNV Insertion 17803354

Variation tolerance for STARD9 Gene

Gene Damage Index Score: 14.35; 96.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD9 Gene

HapMap Linkage Disequilibrium report
STARD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD9 Gene

Disorders for STARD9 Gene

Relevant External Links for STARD9

Genetic Association Database (GAD)
STARD9
Human Genome Epidemiology (HuGE) Navigator
STARD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD9

No disorders were found for STARD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD9 Gene

Publications for STARD9 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods. (PMID: 16964419) Halama N. … Jager D. (Int. J. Mol. Med. 2006) 3 23
  3. A unique insertion in STARD9's motor domain regulates its stability. (PMID: 25501367) Senese S. … Torres J.Z. (Mol. Biol. Cell 2015) 3
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for STARD9 Gene

Sources for STARD9 Gene

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