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Aliases for STARD8 Gene

Aliases for STARD8 Gene

  • StAR-Related Lipid Transfer (START) Domain Containing 8 2 3
  • DLC3 3 4 6
  • Deleted In Liver Cancer 3 Protein 3 4
  • START Domain Containing 8 2 3
  • STARTGAP3 3 6
  • KIAA0189 4 6
  • StAR-Related Lipid Transfer Protein 8 3
  • START Domain-Containing Protein 8 4
  • START-GAP3 4
  • ARHGAP38 3
  • StARD8 4
  • DLC-3 4

External Ids for STARD8 Gene

Previous GeneCards Identifiers for STARD8 Gene

  • GC0XP064091
  • GC0XP065390
  • GC0XP066100
  • GC0XP066734
  • GC0XP067650
  • GC0XP067784
  • GC0XP067867
  • GC0XP061695

Summaries for STARD8 Gene

Entrez Gene Summary for STARD8 Gene

  • This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]

GeneCards Summary for STARD8 Gene

STARD8 (StAR-Related Lipid Transfer (START) Domain Containing 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for STARD8 Gene

  • Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.

Gene Wiki entry for STARD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD8 Gene

Genomics for STARD8 Gene

Regulatory Elements for STARD8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STARD8 Gene

Start:
68,647,666 bp from pter
End:
68,725,842 bp from pter
Size:
78,177 bases
Orientation:
Plus strand

Genomic View for STARD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STARD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD8 Gene

Proteins for STARD8 Gene

  • Protein details for STARD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92502-STAR8_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 8
    Protein Accession:
    Q92502
    Secondary Accessions:
    • A8K6T2
    • D3DVT9
    • Q5JST0
    • Q68DG7

    Protein attributes for STARD8 Gene

    Size:
    1023 amino acids
    Molecular mass:
    112601 Da
    Quaternary structure:
    • Binds both the SH2 and PTB domains of TNS1
    SequenceCaution:
    • Sequence=BAA11506.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STARD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD8 Gene

Proteomics data for STARD8 Gene at MOPED

Post-translational modifications for STARD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD8 Gene

Domains for STARD8 Gene

Gene Families for STARD8 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • StARD :StAR-related lipid transfer (START) domain containing

Suggested Antigen Peptide Sequences for STARD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92502

UniProtKB/Swiss-Prot:

STAR8_HUMAN :
  • Q92502
Domain:
  • Contains 1 Rho-GAP domain.
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD8: view

Function for STARD8 Gene

Molecular function for STARD8 Gene

UniProtKB/Swiss-Prot Function: Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.

Gene Ontology (GO) - Molecular Function for STARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD8: view

Phenotypes for STARD8 Gene

genes like me logo Genes that share phenotypes with STARD8: view

Animal Model Products

CRISPR Products

miRNA for STARD8 Gene

miRTarBase miRNAs that target STARD8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STARD8 Gene

Localization for STARD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD8 Gene

Cell junction, focal adhesion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD8 Gene COMPARTMENTS Subcellular localization image for STARD8 gene
Compartment Confidence
cytosol 4
nucleus 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for STARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IEA --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with STARD8: view

Pathways for STARD8 Gene

genes like me logo Genes that share pathways with STARD8: view

Pathways by source for STARD8 Gene

3 Reactome pathways for STARD8 Gene

Interacting Proteins for STARD8 Gene

Gene Ontology (GO) - Biological Process for STARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with STARD8: view

Transcripts for STARD8 Gene

Unigene Clusters for STARD8 Gene

StAR-related lipid transfer (START) domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STARD8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5: -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for STARD8 Gene

GeneLoc Exon Structure for
STARD8
ECgene alternative splicing isoforms for
STARD8

Expression for STARD8 Gene

mRNA expression in normal human tissues for STARD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STARD8 Gene

SOURCE GeneReport for Unigene cluster for STARD8 Gene Hs.95140

mRNA Expression by UniProt/SwissProt for STARD8 Gene

Q92502-STAR8_HUMAN
Tissue specificity: Widely expressed with highest levels in kidney, lung and placenta.
genes like me logo Genes that share expressions with STARD8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for STARD8 Gene

Orthologs for STARD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STARD8 35
  • 86.86 (n)
  • 86.14 (a)
STARD8 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD8 35
  • 86.5 (n)
  • 85.9 (a)
STARD8 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard8 35
  • 83.58 (n)
  • 85.26 (a)
Stard8 16
Stard8 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STARD8 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD8 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard8 35
  • 83.48 (n)
  • 85.03 (a)
chicken
(Gallus gallus)
Aves STARD8 35
  • 68.71 (n)
  • 65.01 (a)
STARD8 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD8 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stard8 35
  • 58.34 (n)
  • 57.08 (a)
stard8 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for STARD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD8 Gene

ENSEMBL:
Gene Tree for STARD8 (if available)
TreeFam:
Gene Tree for STARD8 (if available)

Paralogs for STARD8 Gene

Selected SIMAP similar genes for STARD8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STARD8: view

Variants for STARD8 Gene

Sequence variations from dbSNP and Humsavar for STARD8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs947543 -- 68,717,367(+) CTCAC(C/T)GAGCT reference, synonymous-codon
rs1342133 -- 68,702,886(-) AGTTA(A/T)ACAGT intron-variant
rs1539284 -- 68,688,484(-) TGCCA(C/T)GGCCT intron-variant
rs1539285 -- 68,688,269(-) CCTCA(A/G)AGGCC intron-variant
rs1539286 -- 68,688,247(-) TCGGA(A/G)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD8 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv2669195 CNV Deletion 23128226
nsv6943 CNV Insertion 18451855
nsv516469 CNV Gain 19592680
nsv6944 CNV Loss 18451855

Relevant External Links for STARD8 Gene

HapMap Linkage Disequilibrium report
STARD8
Locus Specific Mutation Databases (LSDB)
STARD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD8 Gene

Disorders for STARD8 Gene

(1) University of Copenhagen DISEASES for STARD8 Gene

Relevant External Links for STARD8

Genetic Association Database (GAD)
STARD8
Human Genome Epidemiology (HuGE) Navigator
STARD8
genes like me logo Genes that share disorders with STARD8: view

No data available for UniProtKB/Swiss-Prot for STARD8 Gene

Publications for STARD8 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. (PMID: 17297465) Durkin M.E. … Popescu N.C. (Oncogene 2007) 3 4
  5. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. (PMID: 17517630) Qian X. … Lowy D.R. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4

Products for STARD8 Gene

Sources for STARD8 Gene

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