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Aliases for STARD7 Gene

Aliases for STARD7 Gene

  • StAR Related Lipid Transfer Domain Containing 7 2 3 5
  • Gestational Trophoblastic Tumor Protein 1 3 4
  • START Domain-Containing Protein 7 3 4
  • START Domain Containing 7 2 3
  • GTT1 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 7 3
  • StAR-Related Lipid Transfer Protein 7, Mitochondrial 3
  • StARD7 4

External Ids for STARD7 Gene

Previous GeneCards Identifiers for STARD7 Gene

  • GC02M094722
  • GC02M095304
  • GC02M096318
  • GC02M096335
  • GC02M096272
  • GC02M096850
  • GC02M090811

Summaries for STARD7 Gene

GeneCards Summary for STARD7 Gene

STARD7 (StAR Related Lipid Transfer Domain Containing 7) is a Protein Coding gene. Diseases associated with STARD7 include Gestational Trophoblastic Tumor. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is PCTP.

UniProtKB/Swiss-Prot for STARD7 Gene

  • May play a protective role in mucosal tissues by preventing exaggerated allergic responses.

Gene Wiki entry for STARD7 Gene

Additional gene information for STARD7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD7 Gene

Genomics for STARD7 Gene

GeneHancer (GH) Regulatory Elements for STARD7 Gene

Promoters and enhancers for STARD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I096206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 108 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B STARD7-AS1 STARD7 KANSL3 SNRNP200 ANKRD36 LMAN2L CNNM3 SEMA4C GPAT2 CIAO1
GH02I096255 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 13 -50.4 -50427 7.2 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ZNF766 DUSP2 CIAO1 STARD7 STARD7-AS1 ASTL ITPRIPL1 ENSG00000230747 SNRNP200 TMEM127 ARID5A
GH02I096161 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +45.4 45406 4.1 HDGF PKNOX1 SMAD1 BATF KLF5 IRF4 ZNF143 ATF7 ETV6 FOS ASTL ADRA2B ITPRIPL1 STARD7-AS1 STARD7 ENSG00000230747 KCNIP3 DUSP2 ARID5A KANSL3
GH02I096249 Enhancer 1.3 Ensembl ENCODE dbSUPER 13 -43.2 -43213 5.7 PKNOX1 FOXA2 ARID4B NEUROD1 ZNF48 SLC30A9 ATF7 RXRA SP5 MIER2 PIR47017 PIR39280 GC02M096255 GC02M096251 ITPRIPL1 STARD7 STARD7-AS1 ASTL DUSP2 ENSG00000230747
GH02I096186 Enhancer 1 ENCODE dbSUPER 12.7 +21.4 21392 1.4 FOXA2 MLX ARID4B RAD21 ZSCAN9 RARA MIXL1 MIER2 PPARG KAT8 STARD7-AS1 STARD7 ASTL DUSP2 ADRA2B GC02P096183
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STARD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STARD7 gene promoter:

Genomic Locations for STARD7 Gene

Genomic Locations for STARD7 Gene
chr2:96,184,859-96,208,846
(GRCh38/hg38)
Size:
23,988 bases
Orientation:
Minus strand
chr2:96,850,597-96,874,573
(GRCh37/hg19)

Genomic View for STARD7 Gene

Genes around STARD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD7 Gene

Proteins for STARD7 Gene

  • Protein details for STARD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ5-STAR7_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 7, mitochondrial
    Protein Accession:
    Q9NQZ5
    Secondary Accessions:
    • D3DXG9
    • Q53T44
    • Q6GU43
    • Q969M6

    Protein attributes for STARD7 Gene

    Size:
    370 amino acids
    Molecular mass:
    43113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF81750.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=AAH07894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH08894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09998.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12774.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12793.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13279.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14076.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14274.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH32106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for STARD7 Gene

Post-translational modifications for STARD7 Gene

No Post-translational modifications

Other Protein References for STARD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD7 Gene

Domains & Families for STARD7 Gene

Gene Families for STARD7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for STARD7 Gene

Suggested Antigen Peptide Sequences for STARD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STARD7: view

No data available for UniProtKB/Swiss-Prot for STARD7 Gene

Function for STARD7 Gene

Molecular function for STARD7 Gene

UniProtKB/Swiss-Prot Function:
May play a protective role in mucosal tissues by preventing exaggerated allergic responses.

Phenotypes From GWAS Catalog for STARD7 Gene

Gene Ontology (GO) - Molecular Function for STARD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD7: view
genes like me logo Genes that share phenotypes with STARD7: view

Animal Models for STARD7 Gene

MGI Knock Outs for STARD7:

Animal Model Products

miRNA for STARD7 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD7 Gene

Localization for STARD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD7 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD7 gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STARD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with STARD7: view

Pathways & Interactions for STARD7 Gene

genes like me logo Genes that share pathways with STARD7: view

Gene Ontology (GO) - Biological Process for STARD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with STARD7: view

No data available for SIGNOR curated interactions for STARD7 Gene

Drugs & Compounds for STARD7 Gene

No Compound Related Data Available

Transcripts for STARD7 Gene

Unigene Clusters for STARD7 Gene

StAR-related lipid transfer (START) domain containing 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for STARD7 Gene

GeneLoc Exon Structure for
STARD7
ECgene alternative splicing isoforms for
STARD7

Expression for STARD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STARD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD7 Gene

This gene is overexpressed in Neutrophil (29.3), Breast (10.8), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STARD7 Gene



Protein tissue co-expression partners for STARD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD7 Gene:

STARD7

SOURCE GeneReport for Unigene cluster for STARD7 Gene:

Hs.469331

mRNA Expression by UniProt/SwissProt for STARD7 Gene:

Q9NQZ5-STAR7_HUMAN
Tissue specificity: Expressed in nasal epithelial cells. Down-regulated in nasal epithelial cells in patients experiencing an asthma exacerbation as compared to stable asthmatics and healthy controls.

Evidence on tissue expression from TISSUES for STARD7 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Lung(3.3)
  • Heart(2.4)
  • Liver(2.4)
  • Muscle(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with STARD7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD7 Gene

Orthologs for STARD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD7 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia STARD7 33 34
  • 92.58 (n)
rat
(Rattus norvegicus)
Mammalia Stard7 33
  • 89.72 (n)
mouse
(Mus musculus)
Mammalia Stard7 33 16 34
  • 89.1 (n)
cow
(Bos Taurus)
Mammalia STARD7 33 34
  • 88.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STARD7 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STARD7 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD7 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard7 33
  • 67.01 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-200l5.5 33
  • 64.58 (n)
STARD7 34
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004792 33
  • 45.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6565 35 33
  • 45.59 (n)
worm
(Caenorhabditis elegans)
Secernentea C06H2.2 34
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7984 34
  • 30 (a)
OneToOne
Species where no ortholog for STARD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD7 Gene

ENSEMBL:
Gene Tree for STARD7 (if available)
TreeFam:
Gene Tree for STARD7 (if available)

Paralogs for STARD7 Gene

Paralogs for STARD7 Gene

genes like me logo Genes that share paralogs with STARD7: view

Variants for STARD7 Gene

Sequence variations from dbSNP and Humsavar for STARD7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000072413 -- 96,203,793(-) T/C intron_variant
rs1000179463 -- 96,209,214(-) C/T upstream_transcript_variant
rs1000190977 -- 96,201,659(-) A/G intron_variant
rs1000286581 -- 96,196,784(-) T/A/C intron_variant
rs1000292372 -- 96,196,626(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STARD7 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv525780 CNV loss 19592680
nsv834305 CNV gain 17160897

Variation tolerance for STARD7 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD7 Gene

Disorders for STARD7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STARD7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gestational trophoblastic tumor
  • gestational trophoblastic disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STARD7

genes like me logo Genes that share disorders with STARD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STARD7 Gene

Publications for STARD7 Gene

  1. GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization. (PMID: 15013637) Durand S … Genti-Raimondi S (Placenta 2004) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  5. Suppression of StarD7 promotes endoplasmic reticulum stress and induces ROS production. (PMID: 27554972) Flores-Martín J … Genti-Raimondi S (Free radical biology & medicine 2016) 3 58

Products for STARD7 Gene

Sources for STARD7 Gene

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