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Aliases for STARD7 Gene

Aliases for STARD7 Gene

  • StAR Related Lipid Transfer Domain Containing 7 2 3 5
  • Gestational Trophoblastic Tumor Protein 1 3 4
  • START Domain-Containing Protein 7 3 4
  • START Domain Containing 7 2 3
  • GTT1 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 7 3
  • StAR-Related Lipid Transfer Domain Containing 7 3
  • StARD7 4

External Ids for STARD7 Gene

Previous GeneCards Identifiers for STARD7 Gene

  • GC02M094722
  • GC02M095304
  • GC02M096318
  • GC02M096335
  • GC02M096272
  • GC02M096850
  • GC02M090811

Summaries for STARD7 Gene

Entrez Gene Summary for STARD7 Gene

  • Although the function of this gene is not known, its existence is supported by mRNA and EST data. The predicted gene product contains a region similar to the STAR-related lipid transfer (START) domain, which is often present in proteins involved in the cell signaling mediated by lipid binding. Alternatively spliced transcript variants have been described, although some transcripts occur only in cancer cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for STARD7 Gene

STARD7 (StAR Related Lipid Transfer Domain Containing 7) is a Protein Coding gene. Diseases associated with STARD7 include Gestational Trophoblastic Tumor. GO annotations related to this gene include lipid binding. An important paralog of this gene is PCTP.

UniProtKB/Swiss-Prot for STARD7 Gene

  • May play a protective role in mucosal tissues by preventing exaggerated allergic responses.

Gene Wiki entry for STARD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD7 Gene

Genomics for STARD7 Gene

Regulatory Elements for STARD7 Gene

Enhancers for STARD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STARD7 on UCSC Golden Path with GeneCards custom track

Promoters for STARD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STARD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for STARD7 Gene

Chromosome:
2
Start:
96,184,859 bp from pter
End:
96,208,846 bp from pter
Size:
23,988 bases
Orientation:
Minus strand

Genomic View for STARD7 Gene

Genes around STARD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD7 Gene

Proteins for STARD7 Gene

  • Protein details for STARD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ5-STAR7_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 7, mitochondrial
    Protein Accession:
    Q9NQZ5
    Secondary Accessions:
    • D3DXG9
    • Q53T44
    • Q6GU43
    • Q969M6

    Protein attributes for STARD7 Gene

    Size:
    370 amino acids
    Molecular mass:
    43113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF81750.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305}; Sequence=AAH07894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH08894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09998.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12774.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12793.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13279.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14076.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14274.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH32106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for STARD7 Gene

Proteomics data for STARD7 Gene at MOPED

Post-translational modifications for STARD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD7 Gene

Domains & Families for STARD7 Gene

Gene Families for STARD7 Gene

Protein Domains for STARD7 Gene

Suggested Antigen Peptide Sequences for STARD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ5

UniProtKB/Swiss-Prot:

STAR7_HUMAN :
  • Contains 1 START domain.
Domain:
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD7: view

Function for STARD7 Gene

Molecular function for STARD7 Gene

UniProtKB/Swiss-Prot Function:
May play a protective role in mucosal tissues by preventing exaggerated allergic responses.
genes like me logo Genes that share phenotypes with STARD7: view

Animal Model Products

miRNA for STARD7 Gene

miRTarBase miRNAs that target STARD7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STARD7 Gene

Localization for STARD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD7 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD7 Gene COMPARTMENTS Subcellular localization image for STARD7 gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for STARD7 Gene

Pathways & Interactions for STARD7 Gene

SuperPathways for STARD7 Gene

No Data Available

Interacting Proteins for STARD7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338030%0d%0a9606.ENSP00000358081%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000338030 Q9NQZ5-STAR7_HUMAN for STARD7 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for STARD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STARD7 Gene

Drugs & Compounds for STARD7 Gene

No Compound Related Data Available

Transcripts for STARD7 Gene

Unigene Clusters for STARD7 Gene

StAR-related lipid transfer (START) domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for STARD7 Gene

GeneLoc Exon Structure for
STARD7
ECgene alternative splicing isoforms for
STARD7

Expression for STARD7 Gene

mRNA expression in normal human tissues for STARD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD7 Gene

This gene is overexpressed in Neutrophil (29.3), Breast (10.8), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STARD7 Gene



SOURCE GeneReport for Unigene cluster for STARD7 Gene Hs.469331

mRNA Expression by UniProt/SwissProt for STARD7 Gene

Q9NQZ5-STAR7_HUMAN
Tissue specificity: Expressed in nasal epithelial cells. Down-regulated in nasal epithelial cells in patients experiencing an asthma exacerbation as compared to stable asthmatics and healthy controls.
genes like me logo Genes that share expression patterns with STARD7: view

Protein tissue co-expression partners for STARD7 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for STARD7 Gene

Orthologs for STARD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD7 35
  • 88.85 (n)
  • 91.82 (a)
STARD7 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD7 35
  • 92.58 (n)
  • 95.66 (a)
STARD7 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard7 35
  • 89.1 (n)
  • 92.16 (a)
Stard7 16
Stard7 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD7 35
  • 99.46 (n)
  • 99.73 (a)
STARD7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard7 35
  • 89.72 (n)
  • 96.28 (a)
oppossum
(Monodelphis domestica)
Mammalia STARD7 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD7 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD7 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard7 35
  • 67.01 (n)
  • 71.18 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-200l5.5 35
  • 64.58 (n)
  • 65 (a)
STARD7 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6565 37
  • 37 (a)
CG6565 35
  • 45.59 (n)
  • 34.27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004792 35
  • 45.97 (n)
  • 36.93 (a)
worm
(Caenorhabditis elegans)
Secernentea C06H2.2 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7984 36
  • 30 (a)
OneToOne
Species with no ortholog for STARD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD7 Gene

ENSEMBL:
Gene Tree for STARD7 (if available)
TreeFam:
Gene Tree for STARD7 (if available)

Paralogs for STARD7 Gene

Paralogs for STARD7 Gene

genes like me logo Genes that share paralogs with STARD7: view

Variants for STARD7 Gene

Sequence variations from dbSNP and Humsavar for STARD7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2276650 - 96,195,421(-) GCAAC(C/G)TTGGG reference, missense
rs1808802 -- 96,189,561(-) cgcct(A/G)gctaa intron-variant
rs1898342 -- 96,205,079(+) CATTA(A/G)ATTTG intron-variant
rs997547 -- 96,193,296(-) GTGAT(C/T)GAGAG reference, synonymous-codon
rs997548 -- 96,193,176(-) CCTGC(C/G/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD7 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv834305 CNV Gain 17160897
nsv525780 CNV Loss 19592680
nsv874679 CNV Gain 21882294

Variation tolerance for STARD7 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STARD7 Gene

Disorders for STARD7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STARD7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gestational trophoblastic tumor
  • gestational trophoblastic neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for STARD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD7
genes like me logo Genes that share disorders with STARD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STARD7 Gene

Publications for STARD7 Gene

  1. GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization. (PMID: 15013637) Durand S. … Genti-Raimondi S. (Placenta 2004) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PMID: 23247143) Yu B. … Boerwinkle E. (Circ Cardiovasc Genet 2013) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for STARD7 Gene

Sources for STARD7 Gene

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