STARD6 Gene
protein-coding GIFtS: 47
GCID: GC18M051850
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StAR-related lipid transfer (START) domain containing 6(Previous name: START domain containing 6 )
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Aliases
for STARD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| StAR-Related Lipid Transfer (START) Domain Containing 61 2 | | START Domain Containing 61 2 | | START Domain-Containing Protein 62 3 | | StAR-Related Lipid Transfer Protein 62 | | StARD63 |
Export aliases for STARD6 gene to outside databasesPrevious GC identifers: GC18M052021 GC18M051786 GC18M050103 GC18M050105 GC18M048706 |
Summaries
for STARD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STARD6:
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g.,SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive andSREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis anduptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acuteregulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acidSTAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 (PubMed 12011452)).(supplied byOMIM, Mar 2008)
UniProtKB/Swiss-Prot: STAR6_HUMAN, P59095Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or othersterols (By similarity)
|
Genomic Views
for STARD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STARD6 gene promoter:
TBP AML1a Nkx2-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) CUTL1 STAT5A POU3F2 GATA-1 RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for STARD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STARD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.2 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21.2STARD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M051850: view genomic region
(about GC identifiers)
Start:
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51,850,964 bp from pter |
End:
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51,884,334 bp from pter |
Size:
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33,371 bases |
Orientation:
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minus strand |
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Proteins
for STARD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAR6_HUMAN, P59095 (See
protein sequence)Recommended Name: StAR-related lipid transfer protein 6 Size: 220 amino acids; 25022 DaExplore the universe of human proteins at neXtProt for STARD6: NX_P59095
STARD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_631910.1
ENSEMBL proteins: ENSP00000463611 ENSP00000462349 ENSP00000464406 ENSP00000464377 ENSP00000310814 Reactome Protein details: P59095
Human Recombinant Protein Products:
STARD6 Antibody Products:
Assay Products for STARD6: |
Protein
Domains /
Families
for STARD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STARD6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59095ProtoNet protein and cluster: P59095 UniProtKB/Swiss-Prot: STAR6_HUMAN, P59095Similarity: Contains 1 START domain |
Function
for STARD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STAR6_HUMAN, P59095Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or othersterols (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STARD6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008289 | lipid binding |
IEA | -- |
STARD6 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for STARD6:
|
Pathways & Interactions
for STARD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Vitamin D (calciferol) metabolism | | | 3 | Pregnenolone biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for STARD6
STARD6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STARD6
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006869 | lipid transport |
IEA | -- |
STARD6 for ontologies About GeneDecksing
|
Drugs & Compounds
for STARD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STARD6
Search CenterWatch for drugs/clinical trials and news about STARD6 / STAR6
|
Transcripts
for STARD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STARD6 gene: NM_139171.1 Unigene Cluster for STARD6: StAR-related lipid transfer (START) domain containing 6 Hs.438779 [show with all ESTs]Unigene Representative Sequence: DB4563415 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000580990 ENST00000581310 ENST00000577499 ENST00000584040 ENST00000307844(uc010xdt.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STARD6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STARD6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STARD6 (NM_139171) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STARD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD6 |
Additional cDNA sequence: AF480305.1 4 DOTS entries: DT.97825299 DT.40203344 DT.40306660 DT.107695 10 AceView cDNA sequences: AF480305 NM_139171 BX281825 AA813687 BX119548 AI215441 AW873635 AA968431 BQ435863 AI914982
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for STARD6 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for STARD6
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Expression
for STARD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STARD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STARD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STARD6
SOURCE GeneReport for Unigene cluster: Hs.438779
SABiosciences Custom PCR Arrays for STARD6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STARD6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STARD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STARD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD6 |
Orthologs
for STARD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STARD6 gene from 2/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
STARD66 |
-- |
40(a) |
1 ↔ 1 |
GL343213.1(130093-141750) |
worm
(Caenorhabditis elegans) |
Secernentea |
K02D3.26 |
Protein K02D3.2 |
18(a) |
1 → many |
X(13708652-13711895) |
ENSEMBL Gene Tree for STARD6 (if available)
TreeFam Gene Tree for STARD6 (if available) |
Paralogs
for STARD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STARD6 gene
- STARD42 STARD52
3 SIMAP similar genes for STARD6 using alignment to 3 protein entries: STAR6_HUMAN (see all proteins):DDX39A STARD5 STARD4
STARD6 for paralogs About GeneDecksing
|
Genomic Variants
for STARD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STARD6 (51850964 - 51884334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STARD6
2 CNVs: 88857 77892 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STARD6 |
|
Disorders
/ Diseases
for STARD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STARD6 for disorders About GeneDecksing
OMIM gene information: 607051
OMIM disorders: --
1  disease for STARD6: About MalaCardscholesterol
Human Genome Epidemiology (HuGE) Navigator: STARD6 (3 documents)
Export disorders for STARD6 gene to outside databases
|
Publications
for STARD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STARD6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with STARD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PubMed id 12011452)1, 2, 3 Soccio R.E....Breslow J.L. (2002)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- StAR-like activity and molten globule behavior of StARD6, a male germ-line protein. (PubMed id 18211099)9 Bose H.S....Miller W.L. (2008)
- Human StarD5, a cytosolic StAR-related lipid binding protein. (PubMed id 15897605)9 Rodriguez-Agudo D....Pandak W.M. (2005)
|
External Searches for STARD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STARD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STARD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STARD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STARD6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STARD6 gene:
Search GeneIP for patents involving STARD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STARD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STARD6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STARD6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STARD6 | | | OriGene Protein Over-expression Lysate for STARD6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STARD6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STARD6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STARD6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |  |  |  | |
| | | | Search Tocris compounds for STARD6 |
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 | | | STARD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD6 |
|  |  |  | | | | Search ThermoFisher Antibodies for STARD6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD6 |
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