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Aliases for STARD6 Gene

Aliases for STARD6 Gene

  • StAR Related Lipid Transfer Domain Containing 6 2 3 5
  • START Domain-Containing Protein 6 4
  • START Domain Containing 6 2
  • StARD6 4

External Ids for STARD6 Gene

Previous GeneCards Identifiers for STARD6 Gene

  • GC18M052021
  • GC18M051786
  • GC18M050103
  • GC18M050105
  • GC18M048706
  • GC18M051850

Summaries for STARD6 Gene

Entrez Gene Summary for STARD6 Gene

  • Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STARD6 Gene

STARD6 (StAR Related Lipid Transfer Domain Containing 6) is a Protein Coding gene. Among its related pathways are Metabolism of steroid hormones and Metabolism. GO annotations related to this gene include lipid binding. An important paralog of this gene is STARD5.

UniProtKB/Swiss-Prot for STARD6 Gene

  • May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD6 Gene

Genomics for STARD6 Gene

Regulatory Elements for STARD6 Gene

Enhancers for STARD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around STARD6 on UCSC Golden Path with GeneCards custom track

Promoters for STARD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for STARD6 Gene

54,324,358 bp from pter
54,357,964 bp from pter
33,607 bases
Minus strand

Genomic View for STARD6 Gene

Genes around STARD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD6 Gene

Proteins for STARD6 Gene

  • Protein details for STARD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    StAR-related lipid transfer protein 6
    Protein Accession:

    Protein attributes for STARD6 Gene

    220 amino acids
    Molecular mass:
    25022 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STARD6 Gene

neXtProt entry for STARD6 Gene

Post-translational modifications for STARD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD6 Gene

No data available for DME Specific Peptides for STARD6 Gene

Domains & Families for STARD6 Gene

Gene Families for STARD6 Gene

Protein Domains for STARD6 Gene

Suggested Antigen Peptide Sequences for STARD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 START domain.
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD6: view

Function for STARD6 Gene

Molecular function for STARD6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Ontology (GO) - Molecular Function for STARD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD6: view
genes like me logo Genes that share phenotypes with STARD6: view

Animal Model Products

CRISPR Products

miRNA for STARD6 Gene

miRTarBase miRNAs that target STARD6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STARD6 Gene

Localization for STARD6 Gene

Subcellular locations from

Jensen Localization Image for STARD6 Gene COMPARTMENTS Subcellular localization image for STARD6 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STARD6 Gene

Pathways & Interactions for STARD6 Gene

genes like me logo Genes that share pathways with STARD6: view

Pathways by source for STARD6 Gene

Interacting Proteins for STARD6 Gene

Selected Interacting proteins: P59095-STAR6_HUMAN for STARD6 Gene via IID

Gene Ontology (GO) - Biological Process for STARD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with STARD6: view

No data available for SIGNOR curated interactions for STARD6 Gene

Drugs & Compounds for STARD6 Gene

No Compound Related Data Available

Transcripts for STARD6 Gene

mRNA/cDNA for STARD6 Gene

(5) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for STARD6 Gene

StAR-related lipid transfer (START) domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -

Relevant External Links for STARD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STARD6 Gene

mRNA expression in normal human tissues for STARD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STARD6 Gene

This gene is overexpressed in Testis (x38.7).

Protein differential expression in normal tissues from HIPED for STARD6 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STARD6 Gene

Protein tissue co-expression partners for STARD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD6 Gene:


SOURCE GeneReport for Unigene cluster for STARD6 Gene:

genes like me logo Genes that share expression patterns with STARD6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for STARD6 Gene

Orthologs for STARD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STARD6 34
  • 85.55 (n)
  • 73.99 (a)
  • 74 (a)
(Canis familiaris)
Mammalia STARD6 34
  • 87.42 (n)
  • 79.55 (a)
  • 78 (a)
(Mus musculus)
Mammalia Stard6 34
  • 81.43 (n)
  • 71.69 (a)
Stard6 16
Stard6 35
  • 67 (a)
(Pan troglodytes)
Mammalia STARD6 34
  • 99.09 (n)
  • 97.73 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Stard6 34
  • 80.52 (n)
  • 72.15 (a)
(Monodelphis domestica)
Mammalia STARD6 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia STARD6 35
  • 59 (a)
(Anolis carolinensis)
Reptilia STARD6 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496774 34
  • 59.97 (n)
  • 50.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
-- 35
  • 26 (a)
Species where no ortholog for STARD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STARD6 Gene

Gene Tree for STARD6 (if available)
Gene Tree for STARD6 (if available)

Paralogs for STARD6 Gene

Paralogs for STARD6 Gene

(3) SIMAP similar genes for STARD6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STARD6: view

Variants for STARD6 Gene

Sequence variations from dbSNP and Humsavar for STARD6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2917782 - 54,329,351(-) CAATG(A/G)AAGAG reference, missense
rs7240948 -- 54,338,086(+) AGCCA(C/T)ATTCA intron-variant
rs1344885 -- 54,338,134(-) TACTT(A/T)TGTCC intron-variant
rs1344886 -- 54,337,975(-) TGCTC(A/G/T)TAGTG intron-variant
rs1344887 -- 54,354,392(+) cctgg(A/C)acaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD6 Gene

Variant ID Type Subtype PubMed ID
esv2670481 CNV deletion 23128226
esv2717126 CNV deletion 23290073
esv2717127 CNV deletion 23290073
esv3555418 CNV deletion 23714750
esv3642579 CNV loss 21293372
nsv962973 CNV deletion 23825009

Variation tolerance for STARD6 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD6 Gene

Disorders for STARD6 Gene

Relevant External Links for STARD6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STARD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD6 Gene

Publications for STARD6 Gene

  1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PMID: 12011452) Soccio R.E. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism. (PMID: 24440759) Calderon-Dominguez M. … RodrA-guez-Agudo D. (Int. J. Biochem. Cell Biol. 2014) 3 65
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 65
  5. StAR-like activity and molten globule behavior of StARD6, a male germ-line protein. (PMID: 18211099) Bose H.S. … Miller W.L. (Biochemistry 2008) 22 65

Products for STARD6 Gene

Sources for STARD6 Gene

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