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Aliases for STARD5 Gene

Aliases for STARD5 Gene

  • StAR Related Lipid Transfer Domain Containing 5 2 3 5
  • START Domain-Containing Protein 5 4
  • START Domain Containing 5 2
  • StARD5 4

External Ids for STARD5 Gene

Previous GeneCards Identifiers for STARD5 Gene

  • GC15M077563
  • GC15M074762
  • GC15M079180
  • GC15M079320
  • GC15M079392
  • GC15M081601
  • GC15M058363

Summaries for STARD5 Gene

Entrez Gene Summary for STARD5 Gene

  • Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for STARD5 Gene

STARD5 (StAR Related Lipid Transfer Domain Containing 5) is a Protein Coding gene. Among its related pathways are Metabolism of steroid hormones and Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF). GO annotations related to this gene include lipid binding and bile acid binding. An important paralog of this gene is STARD6.

UniProtKB/Swiss-Prot for STARD5 Gene

  • May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Wiki entry for STARD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD5 Gene

Genomics for STARD5 Gene

Regulatory Elements for STARD5 Gene

Enhancers for STARD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around STARD5 on UCSC Golden Path with GeneCards custom track

Promoters for STARD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for STARD5 Gene

Chromosome:
15
Start:
81,309,053 bp from pter
End:
81,324,183 bp from pter
Size:
15,131 bases
Orientation:
Minus strand

Genomic View for STARD5 Gene

Genes around STARD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD5 Gene

Proteins for STARD5 Gene

  • Protein details for STARD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY2-STAR5_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 5
    Protein Accession:
    Q9NSY2
    Secondary Accessions:
    • P59094

    Protein attributes for STARD5 Gene

    Size:
    213 amino acids
    Molecular mass:
    23794 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STARD5 Gene

    Alternative splice isoforms for STARD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD5 Gene

Post-translational modifications for STARD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD5 Gene

Domains & Families for STARD5 Gene

Gene Families for STARD5 Gene

Protein Domains for STARD5 Gene

Suggested Antigen Peptide Sequences for STARD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSY2

UniProtKB/Swiss-Prot:

STAR5_HUMAN :
  • Contains 1 START domain.
Domain:
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD5: view

Function for STARD5 Gene

Molecular function for STARD5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Ontology (GO) - Molecular Function for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015485 cholesterol binding IDA 18403318
GO:0032052 bile acid binding IEA --
genes like me logo Genes that share ontologies with STARD5: view
genes like me logo Genes that share phenotypes with STARD5: view

Animal Models for STARD5 Gene

MGI Knock Outs for STARD5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD5 Gene

Localization for STARD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD5 Gene COMPARTMENTS Subcellular localization image for STARD5 gene
Compartment Confidence
cytosol 5
extracellular 2
endoplasmic reticulum 1
endosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STARD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STARD5 Gene

Pathways & Interactions for STARD5 Gene

genes like me logo Genes that share pathways with STARD5: view

Interacting Proteins for STARD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304032%0d%0a9606.ENSP00000276449%0d%0a
Selected Interacting proteins: ENSP00000304032 Q9NSY2-STAR5_HUMAN for STARD5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with STARD5: view

No data available for SIGNOR curated interactions for STARD5 Gene

Drugs & Compounds for STARD5 Gene

No Compound Related Data Available

Transcripts for STARD5 Gene

Unigene Clusters for STARD5 Gene

StAR-related lipid transfer (START) domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:
SP6: - -

Relevant External Links for STARD5 Gene

GeneLoc Exon Structure for
STARD5
ECgene alternative splicing isoforms for
STARD5

Expression for STARD5 Gene

mRNA expression in normal human tissues for STARD5 Gene

mRNA differential expression in normal tissues according to GTEx for STARD5 Gene

This gene is overexpressed in Liver (x6.7), Skin - Sun Exposed (Lower leg) (x5.6), and Skin - Not Sun Exposed (Suprapubic) (x5.6).

Protein differential expression in normal tissues from HIPED for STARD5 Gene

This gene is overexpressed in Oral epithelium (21.0), Gallbladder (11.6), Esophagus (7.2), Liver (6.8), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STARD5 Gene



NURSA nuclear receptor signaling pathways regulating expression of STARD5 Gene:

STARD5

SOURCE GeneReport for Unigene cluster for STARD5 Gene:

Hs.513075
genes like me logo Genes that share expression patterns with STARD5: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for STARD5 Gene

Orthologs for STARD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD5 34
  • 84.99 (n)
  • 81.52 (a)
STARD5 35
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD5 34
  • 84.82 (n)
  • 82.16 (a)
STARD5 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD5 34
  • 99.37 (n)
  • 99.06 (a)
STARD5 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard5 34
  • 84.12 (n)
  • 84.43 (a)
oppossum
(Monodelphis domestica)
Mammalia STARD5 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD5 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard5 35
  • 84 (a)
OneToOne
Stard5 16
Stard5 34
  • 83.96 (n)
  • 83.96 (a)
chicken
(Gallus gallus)
Aves STARD5 34
  • 66.18 (n)
  • 60.68 (a)
STARD5 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD5 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard5 34
  • 64.24 (n)
  • 63.11 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC796844 34
  • 59.75 (n)
  • 63.52 (a)
STARD5 35
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for STARD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD5 Gene

ENSEMBL:
Gene Tree for STARD5 (if available)
TreeFam:
Gene Tree for STARD5 (if available)

Paralogs for STARD5 Gene

Paralogs for STARD5 Gene

(2) SIMAP similar genes for STARD5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for STARD5 Gene

genes like me logo Genes that share paralogs with STARD5: view

Variants for STARD5 Gene

Sequence variations from dbSNP and Humsavar for STARD5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_052071 -
rs4238527 -- 81,318,045(+) ACAGA(A/C)CCTGC intron-variant
rs4384571 -- 81,314,908(+) AAAAA(A/C)AAAAA intron-variant
rs4396495 -- 81,320,590(+) CGGGC(A/G)GCAAT intron-variant
rs4503751 -- 81,318,251(+) TGCAG(A/C)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD5 Gene

Variant ID Type Subtype PubMed ID
esv2749949 CNV deletion 23290073
nsv1048788 CNV loss 25217958

Variation tolerance for STARD5 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD5 Gene

Disorders for STARD5 Gene

Relevant External Links for STARD5

Genetic Association Database (GAD)
STARD5
Human Genome Epidemiology (HuGE) Navigator
STARD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD5

No disorders were found for STARD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD5 Gene

Publications for STARD5 Gene

  1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PMID: 12011452) Soccio R.E. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PMID: 15760897) Soccio R.E. … Breslow J.L. (J. Biol. Chem. 2005) 3 22 65
  4. Human StarD5, a cytosolic StAR-related lipid binding protein. (PMID: 15897605) Rodriguez-Agudo D. … Pandak W.M. (J. Lipid Res. 2005) 3 22 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for STARD5 Gene

Sources for STARD5 Gene

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