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Aliases for STARD5 Gene

Aliases for STARD5 Gene

  • StAR Related Lipid Transfer Domain Containing 5 2 3 5
  • START Domain-Containing Protein 5 4
  • START Domain Containing 5 2
  • StARD5 4

External Ids for STARD5 Gene

Previous GeneCards Identifiers for STARD5 Gene

  • GC15M077563
  • GC15M074762
  • GC15M079180
  • GC15M079320
  • GC15M079392
  • GC15M081601
  • GC15M058363

Summaries for STARD5 Gene

Entrez Gene Summary for STARD5 Gene

  • Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for STARD5 Gene

STARD5 (StAR Related Lipid Transfer Domain Containing 5) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) and Metabolism of steroid hormones. GO annotations related to this gene include lipid binding and bile acid binding. An important paralog of this gene is STARD4.

UniProtKB/Swiss-Prot for STARD5 Gene

  • May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Wiki entry for STARD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD5 Gene

Genomics for STARD5 Gene

Regulatory Elements for STARD5 Gene

Enhancers for STARD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STARD5 on UCSC Golden Path with GeneCards custom track

Promoters for STARD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STARD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for STARD5 Gene

81,309,053 bp from pter
81,324,183 bp from pter
15,131 bases
Minus strand

Genomic View for STARD5 Gene

Genes around STARD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD5 Gene

Proteins for STARD5 Gene

  • Protein details for STARD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    StAR-related lipid transfer protein 5
    Protein Accession:
    Secondary Accessions:
    • P59094

    Protein attributes for STARD5 Gene

    213 amino acids
    Molecular mass:
    23794 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STARD5 Gene

    Alternative splice isoforms for STARD5 Gene


neXtProt entry for STARD5 Gene

Proteomics data for STARD5 Gene at MOPED

Post-translational modifications for STARD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD5 Gene

Domains & Families for STARD5 Gene

Gene Families for STARD5 Gene

Protein Domains for STARD5 Gene

Suggested Antigen Peptide Sequences for STARD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 START domain.
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD5: view

Function for STARD5 Gene

Molecular function for STARD5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Ontology (GO) - Molecular Function for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD5: view
genes like me logo Genes that share phenotypes with STARD5: view

Animal Models for STARD5 Gene

MGI Knock Outs for STARD5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD5 Gene

Localization for STARD5 Gene

Subcellular locations from

Jensen Localization Image for STARD5 Gene COMPARTMENTS Subcellular localization image for STARD5 gene
Compartment Confidence
cytosol 5
extracellular 2
endoplasmic reticulum 1
endosome 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STARD5 Gene

Pathways & Interactions for STARD5 Gene

genes like me logo Genes that share pathways with STARD5: view

Interacting Proteins for STARD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000304032 for STARD5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with STARD5: view

No data available for SIGNOR curated interactions for STARD5 Gene

Drugs & Compounds for STARD5 Gene

No Compound Related Data Available

Transcripts for STARD5 Gene

Unigene Clusters for STARD5 Gene

StAR-related lipid transfer (START) domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP6: - -

Relevant External Links for STARD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STARD5 Gene

mRNA expression in normal human tissues for STARD5 Gene

mRNA differential expression in normal tissues according to GTEx for STARD5 Gene

This gene is overexpressed in Liver (x6.7), Skin - Sun Exposed (Lower leg) (x5.6), and Skin - Not Sun Exposed (Suprapubic) (x5.6).

Protein differential expression in normal tissues from HIPED for STARD5 Gene

This gene is overexpressed in Oral epithelium (21.0), Gallbladder (11.6), Esophagus (7.2), Liver (6.8), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STARD5 Gene

SOURCE GeneReport for Unigene cluster for STARD5 Gene Hs.513075

genes like me logo Genes that share expression patterns with STARD5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STARD5 Gene

Orthologs for STARD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STARD5 35
  • 84.99 (n)
  • 81.52 (a)
  • 81 (a)
(Canis familiaris)
Mammalia STARD5 35
  • 84.82 (n)
  • 82.16 (a)
  • 82 (a)
(Mus musculus)
Mammalia Stard5 35
  • 83.96 (n)
  • 83.96 (a)
Stard5 16
Stard5 36
  • 84 (a)
(Pan troglodytes)
Mammalia STARD5 35
  • 99.37 (n)
  • 99.06 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Stard5 35
  • 84.12 (n)
  • 84.43 (a)
(Monodelphis domestica)
Mammalia STARD5 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia STARD5 36
  • 71 (a)
(Gallus gallus)
Aves STARD5 35
  • 66.18 (n)
  • 60.68 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia STARD5 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stard5 35
  • 64.24 (n)
  • 63.11 (a)
(Danio rerio)
Actinopterygii LOC796844 35
  • 59.75 (n)
  • 63.52 (a)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
-- 36
  • 23 (a)
Species with no ortholog for STARD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD5 Gene

Gene Tree for STARD5 (if available)
Gene Tree for STARD5 (if available)

Paralogs for STARD5 Gene

Paralogs for STARD5 Gene

(2) SIMAP similar genes for STARD5 Gene using alignment to 2 proteins: Pseudogenes for STARD5 Gene

genes like me logo Genes that share paralogs with STARD5: view

Variants for STARD5 Gene

Sequence variations from dbSNP and Humsavar for STARD5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_052071 -
rs5814055 -- 81,314,915(+) AAAAA(-/A)GAATC intron-variant
rs6495559 -- 81,314,254(+) ATAAT(C/T)TGAGC intron-variant
rs6495560 -- 81,315,162(+) GCTAG(A/G)GCCTT intron-variant
rs6495561 -- 81,319,657(+) GACAC(A/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD5 Gene

Variant ID Type Subtype PubMed ID
esv2749949 CNV Deletion 23290073

Variation tolerance for STARD5 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STARD5 Gene

Disorders for STARD5 Gene

Relevant External Links for STARD5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STARD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD5 Gene

Publications for STARD5 Gene

  1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PMID: 12011452) Soccio R.E. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 67
  2. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PMID: 15760897) Soccio R.E. … Breslow J.L. (J. Biol. Chem. 2005) 3 23
  3. Human StarD5, a cytosolic StAR-related lipid binding protein. (PMID: 15897605) Rodriguez-Agudo D. … Pandak W.M. (J. Lipid Res. 2005) 3 23
  4. The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism. (PMID: 24440759) Calderon-Dominguez M. … RodrA-guez-Agudo D. (Int. J. Biochem. Cell Biol. 2014) 3
  5. Thermodynamic and solution state NMR characterization of the binding of secondary and conjugated bile acids to STARD5. (PMID: 23872533) LActourneau D. … LeHoux J.G. (Biochim. Biophys. Acta 2013) 3

Products for STARD5 Gene

Sources for STARD5 Gene