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Aliases for STARD5 Gene

Aliases for STARD5 Gene

  • StAR-Related Lipid Transfer (START) Domain Containing 5 2 3
  • START Domain-Containing Protein 5 4
  • START Domain Containing 5 2
  • StARD5 4

External Ids for STARD5 Gene

Previous GeneCards Identifiers for STARD5 Gene

  • GC15M077563
  • GC15M074762
  • GC15M079180
  • GC15M079320
  • GC15M079392
  • GC15M081601
  • GC15M058363

Summaries for STARD5 Gene

Entrez Gene Summary for STARD5 Gene

  • Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STARD5 Gene

STARD5 (StAR-Related Lipid Transfer (START) Domain Containing 5) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of steroid hormones and vitamin D. GO annotations related to this gene include lipid binding and bile acid binding. An important paralog of this gene is STARD4.

UniProtKB/Swiss-Prot for STARD5 Gene

  • May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Wiki entry for STARD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD5 Gene

Genomics for STARD5 Gene

Regulatory Elements for STARD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STARD5 Gene

Chromosome:
15
Start:
81,309,053 bp from pter
End:
81,324,183 bp from pter
Size:
15,131 bases
Orientation:
Minus strand

Genomic View for STARD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for STARD5 Gene

Proteins for STARD5 Gene

  • Protein details for STARD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY2-STAR5_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 5
    Protein Accession:
    Q9NSY2
    Secondary Accessions:
    • P59094

    Protein attributes for STARD5 Gene

    Size:
    213 amino acids
    Molecular mass:
    23794 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STARD5 Gene

    Alternative splice isoforms for STARD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD5 Gene

Proteomics data for STARD5 Gene at MOPED

Post-translational modifications for STARD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD5 Gene

Domains & Families for STARD5 Gene

Gene Families for STARD5 Gene

Protein Domains for STARD5 Gene

Suggested Antigen Peptide Sequences for STARD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSY2

UniProtKB/Swiss-Prot:

STAR5_HUMAN :
  • Contains 1 START domain.
Domain:
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD5: view

Function for STARD5 Gene

Molecular function for STARD5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Ontology (GO) - Molecular Function for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding --
GO:0032052 bile acid binding IEA --
genes like me logo Genes that share ontologies with STARD5: view
genes like me logo Genes that share phenotypes with STARD5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STARD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for STARD5 Gene

Localization for STARD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD5 Gene COMPARTMENTS Subcellular localization image for STARD5 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STARD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STARD5 Gene

Pathways & Interactions for STARD5 Gene

genes like me logo Genes that share pathways with STARD5: view

Interacting Proteins for STARD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304032%0d%0a9606.ENSP00000276449%0d%0a
Selected Interacting proteins: ENSP00000304032 for STARD5 Gene via STRING

Symbol External ID(s) Details
STAR

Gene Ontology (GO) - Biological Process for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0006869 lipid transport IEA --
GO:0008202 steroid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with STARD5: view

No data available for SIGNOR curated interactions for STARD5 Gene

Drugs & Compounds for STARD5 Gene

No Compound Related Data Available

Transcripts for STARD5 Gene

Unigene Clusters for STARD5 Gene

StAR-related lipid transfer (START) domain containing 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STARD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:
SP6: - -

Relevant External Links for STARD5 Gene

GeneLoc Exon Structure for
STARD5
ECgene alternative splicing isoforms for
STARD5

Expression for STARD5 Gene

mRNA expression in normal human tissues for STARD5 Gene

mRNA differential expression in normal tissues according to GTEx for STARD5 Gene

This gene is overexpressed in Liver (x6.7), Skin - Sun Exposed (Lower leg) (x5.6), and Skin - Not Sun Exposed (Suprapubic) (x5.6).

Protein differential expression in normal tissues from HIPED for STARD5 Gene

This gene is overexpressed in Oral epithelium (21.0), Gallbladder (11.6), Esophagus (7.2), Liver (6.8), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STARD5 Gene



SOURCE GeneReport for Unigene cluster for STARD5 Gene Hs.513075

genes like me logo Genes that share expression patterns with STARD5: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STARD5 Gene

Orthologs for STARD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD5 35
  • 84.99 (n)
  • 81.52 (a)
STARD5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD5 35
  • 84.82 (n)
  • 82.16 (a)
STARD5 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard5 35
  • 83.96 (n)
  • 83.96 (a)
Stard5 16
Stard5 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD5 35
  • 99.37 (n)
  • 99.06 (a)
STARD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard5 35
  • 84.12 (n)
  • 84.43 (a)
oppossum
(Monodelphis domestica)
Mammalia STARD5 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD5 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD5 35
  • 66.18 (n)
  • 60.68 (a)
STARD5 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD5 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard5 35
  • 64.24 (n)
  • 63.11 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC796844 35
  • 59.75 (n)
  • 63.52 (a)
STARD5 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for STARD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD5 Gene

ENSEMBL:
Gene Tree for STARD5 (if available)
TreeFam:
Gene Tree for STARD5 (if available)

Paralogs for STARD5 Gene

Paralogs for STARD5 Gene

(2) SIMAP similar genes for STARD5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for STARD5 Gene

genes like me logo Genes that share paralogs with STARD5: view

Variants for STARD5 Gene

Sequence variations from dbSNP and Humsavar for STARD5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs752522644 -- 81,321,215(+) AAAGA(C/T)GCAAA intron-variant
rs752233551 -- 81,314,306(+) AGGAC(A/G)GCAGG intron-variant
rs752202810 -- 81,313,267(+) TGGAA(-/T)TTGCT reference, frameshift-variant
rs752058856 -- 81,316,097(+) CTGCT(A/C)CCACT intron-variant
rs752015446 -- 81,314,421(+) TCAAC(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD5 Gene

Variant ID Type Subtype PubMed ID
esv2749949 CNV Deletion 23290073

Variation tolerance for STARD5 Gene

Residual Variation Intolerance Score: 78.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD5 Gene

HapMap Linkage Disequilibrium report
STARD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD5 Gene

Disorders for STARD5 Gene

Relevant External Links for STARD5

Genetic Association Database (GAD)
STARD5
Human Genome Epidemiology (HuGE) Navigator
STARD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD5
genes like me logo Genes that share disorders with STARD5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD5 Gene

Publications for STARD5 Gene

  1. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PMID: 15760897) Soccio R.E. … Breslow J.L. (J. Biol. Chem. 2005) 23 67
  2. Human StarD5, a cytosolic StAR-related lipid binding protein. (PMID: 15897605) Rodriguez-Agudo D. … Pandak W.M. (J. Lipid Res. 2005) 23 67
  3. Sertoli cell expression of steroidogenic acute regulatory protein-related lipid transfer 1 and 5 domain-containing proteins and sterol regulatory element binding protein-1 are interleukin-1beta regulated by activation of c-Jun N-terminal kinase and cyclooxygenase-2 and cytokine induction. (PMID: 16123165) Ishikawa T. … Morris P.L. (Endocrinology 2005) 23 67
  4. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PMID: 12011452) Soccio R.E. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  5. The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism. (PMID: 24440759) Calderon-Dominguez M. … RodrA-guez-Agudo D. (Int. J. Biochem. Cell Biol. 2014) 67

Products for STARD5 Gene

Sources for STARD5 Gene

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