Aliases for STARD5 Gene
External Ids for STARD5 Gene
Previous GeneCards Identifiers for STARD5 Gene
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
GeneCards Summary for STARD5 Gene
STARD5 (StAR-Related Lipid Transfer (START) Domain Containing 5) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of steroid hormones and vitamin D. GO annotations related to this gene include lipid binding and bile acid binding. An important paralog of this gene is STARD4.
UniProtKB/Swiss-Prot for STARD5 Gene
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).