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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STARD4 Gene

protein-coding   GIFtS: 52
GCID: GC05M110861

StAR-Related Lipid Transfer (START) Domain Containing 4

(Previous names: START domain containing 4, sterol regulated)
  Search for STARD4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
StAR-Related Lipid Transfer (START) Domain Containing 41 2
START Domain Containing 4, Sterol Regulated1 2
START Domain-Containing Protein 42 3
StAR-Related Lipid Transfer Protein 42
START Domain Containing 4 Sterol-Regulated2
StARD43

External Ids:    HGNC: 180581   Entrez Gene: 1344292   Ensembl: ENSG000001642117   OMIM: 6070495   UniProtKB: Q96DR43   

Export aliases for STARD4 gene to outside databases

Previous GC identifers: GC05M110457 GC05M111277 GC05M110864 GC05M110910 GC05M106012


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STARD4 Gene:
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g.,
SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive
and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol
biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as
steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing
a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002
(PubMed 12011452)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STARD4 Gene: 
STARD4 (StAR-related lipid transfer (START) domain containing 4) is a protein-coding gene. Among its related super-pathways are Steroid hormones and Metabolic pathways. GO annotations related to this gene include lipid binding. An important paralog of this gene is STARD6.

UniProtKB/Swiss-Prot: STAR4_HUMAN, Q96DR4
Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other
sterols (By similarity)

Gene Wiki entry for STARD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STARD4 gene promoter:
         FOXO3   CUTL1   NF-E2 p45   FOXL1   Gfi-1   FOXO3b   RORalpha1   FOXO3a   NF-E2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTARD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for STARD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STARD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22

STARD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STARD4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M110861:  view genomic region     (about GC identifiers)

Start:
110,831,731 bp from pter      End:
110,848,288 bp from pter
Size:
16,558 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STAR4_HUMAN, Q96DR4 (See protein sequence)
Recommended Name: StAR-related lipid transfer protein 4  
Size: 205 amino acids; 23517 Da

Explore the universe of human proteins at neXtProt for STARD4: NX_Q96DR4

Explore proteomics data for STARD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DR4

  • STARD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STARD4 Protein Expression
    REFSEQ proteins: NP_631903.1  
    ENSEMBL proteins: 
     ENSP00000296632   ENSP00000426148   ENSP00000425014   ENSP00000427478   ENSP00000427639  
     ENSP00000425308   ENSP00000407063  
    Reactome Protein details: Q96DR4
    Human Recombinant Protein Products for STARD4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STARD4
    OriGene Protein Over-expression Lysate for STARD4
    OriGene MassSpec for STARD4 
    OriGene Custom Protein Services for STARD4
    GenScript Custom Purified and Recombinant Proteins Services for STARD4
    Novus Biologicals STARD4 Proteins
    Novus Biologicals STARD4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STARD4 


    STARD4 Antibody Products: 
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    Novus Biologicals STARD4 Antibodies
    Abcam antibodies for STARD4
    Cloud-Clone Corp. Antibodies for STARD4 
    Search ThermoFisher Antibodies for STARD4
    LSBio Antibodies in human, mouse, rat for STARD4 

    Assay Products for STARD4: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STARD4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STARD4 
    Cloud-Clone Corp. CLIAs for STARD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    StARD: StAR-related lipid transfer (START) domain containing

    2 InterPro protein domains:
     IPR023393 START-like_dom
     IPR002913 START_lipid-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96DR4

    ProtoNet protein and cluster: Q96DR4

    UniProtKB/Swiss-Prot: STAR4_HUMAN, Q96DR4
    Similarity: Contains 1 START domain


    STARD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAR4_HUMAN, Q96DR4
    Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other
    sterols (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
         
    STARD4 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stard4):
     behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system  no phenotypic analysis 

    STARD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stard4tm1.2Bres for STARD4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STARD4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STARD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STARD4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STARD4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STARD4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate STARD4:
    hsa-miR-3163 hsa-miR-129-3p hsa-miR-938 hsa-miR-3662 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSTARD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STARD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STARD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STARD4
    Sirion Biotech Customized adenovirus for overexpression of STARD4

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for STARD4 (see all 7)
    OriGene ORF clones in mouse, rat for STARD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STARD4 (NM_139164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STARD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD4
    Sirion Biotech Customized lentivirus for stable overexpression of STARD4 
                         Customized lentivirus expression plasmids for stable overexpression of STARD4 

    Cell Line
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    Search LifeMap BioReagents cell lines for STARD4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STARD4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of steroid hormones and vitamin D
    Metabolism of steroid hormones and vitamin D1.00
    Steroid hormones1.00
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
    Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
    4Pregnenolone biosynthesis
    Pregnenolone biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STARD4
        Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

    5        Reactome Pathways for STARD4
        Metabolism of steroid hormones and vitamin D
    Metabolism
    Pregnenolone biosynthesis
    Steroid hormones
    Metabolism of lipids and lipoproteins



    STARD4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STARD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for STARD4 (ENSP000002966324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    STARD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STARD4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STARD4 (STAR4)

    3 Novoseek inferred chemical compound relationships for STARD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterol 56.7 5 15760897 (3)
    lipid 39.8 5 12011453 (2), 15760897 (1), 15897605 (1)
    cholesterol 39.3 4 15760897 (3), 18211099 (1)

    Search CenterWatch for drugs/clinical trials and news about STARD4 / STAR4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STARD4 gene: 
    NM_139164.1  

    Unigene Cluster for STARD4:

    StAR-related lipid transfer (START) domain containing 4
    Hs.93842  [show with all ESTs]
    Unigene Representative Sequence: AL832599
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296632(uc003kph.1 uc010jbw.1 uc010jbx.1) ENST00000512160(uc003kpi.1)
    ENST00000511137 ENST00000502931 ENST00000505803 ENST00000502322(uc003kpj.2)
    ENST00000509887 ENST00000511569 ENST00000511436 ENST00000510346 ENST00000455172
    ENST00000508215
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STARD4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate STARD4:
    hsa-miR-3163 hsa-miR-129-3p hsa-miR-938 hsa-miR-3662 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSTARD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for STARD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STARD4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STARD4 (NM_139164)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STARD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD4
    Sirion Biotech Customized lentivirus for stable overexpression of STARD4 
                         Customized lentivirus expression plasmids for stable overexpression of STARD4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for STARD4
    OriGene qSTAR qPCR primer pairs in human, mouse for STARD4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STARD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STARD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD4

    Additional mRNA sequence: 

    AF480299.1 AK026207.1 AK054566.1 AK125317.1 AK290312.1 AK308851.1 AK310848.1 AK315863.1 
    AK315869.1 AL832599.2 BC019632.1 BC042956.1 

    9 DOTS entries:

    DT.454068  DT.100008098  DT.100789542  DT.91722634  DT.92052567  DT.120846847  DT.102826406  DT.120846864 
    DT.91913018 

    24/135 AceView cDNA sequences (see all 135):

    AA765040 CB127783 BC042956 AI738637 AA252621 AW073854 BQ774229 NM_139164 
    BQ025780 AA255607 CB045787 AI439656 AA807553 AI763053 AK054566 AA243410 
    AA808192 AA125867 BM700581 BP364500 AI888300 BU607573 CA443880 CB241696 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for STARD4 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -                       -     -     -     -                                 
    SP2:                                      -                       -     -     -     -                                 
    SP3:                                      -                                                                           
    SP4:                                      -     -                 -     -     -     -                                 
    SP5:                          -           -                       -     -     -     -                                 


    ECgene alternative splicing isoforms for STARD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STARD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGTTAAA
    STARD4 Expression
    About this image


    See STARD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STARD4

    SOURCE GeneReport for Unigene cluster: Hs.93842
        SABiosciences Custom PCR Arrays for STARD4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for STARD4 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stard41 , 5 StAR-related lipid transfer (START) domain containing more1, 5 85.69(n)1
    86.83(a)1
      18 (18.18 cM)5
    1704591  NM_133774.41  NP_598535.11 
     331993555 
    chicken
    (Gallus gallus)
    Aves STARD41 StAR-related lipid transfer (START) domain containing more 72.03(n)
    75.61(a)
      769322  NM_001079742.1  NP_001073210.1 
    lizard
    (Anolis carolinensis)
    Reptilia STARD46
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343193.1(6432183-6442387)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189082 Xenopus laevis transcribed sequence with weak similarity more 74.77(n)    BX849020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1124661 zgc:112466 60.91(n)
    61.78(a)
      550374  NM_001017679.1  NP_001017679.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K02D3.26
    Protein K02D3.2
    21(a)
    1 → many
    X(13708721-13711964)


    ENSEMBL Gene Tree for STARD4 (if available)
    TreeFam Gene Tree for STARD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STARD4 gene
    STARD62  STARD52  
    3 SIMAP similar genes for STARD4 using alignment to 6 protein entries:     STAR4_HUMAN (see all proteins):
    DKFZp451B0517    STARD5    STARD6

    STARD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/237 SNPs in STARD4 are shown (see all 237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838116271,2
    --106028825(+) TGAGGA/GTTTAG 1 -- us2k10--------
    rs1428762701,2
    --110833525(+) TTCCTA/GAGCTT 1 -- ds50010--------
    rs1890364621,2
    --110833848(+) CATCTA/GGAAGC 1 -- ds50010--------
    rs100757621,2
    C,F,H--110833953(+) TCCATG/ATTTAA 1 -- ds500115Minor allele frequency- A:0.02NS EA NA 2082
    rs1824766281,2
    --110833959(+) TTTAAC/TGGTGA 1 -- ds50010--------
    rs1862902071,2
    --110833992(+) GTATAA/TGTTGA 1 -- ds50010--------
    rs1891060261,2
    --110834010(+) AAAGAC/GAGCAC 1 -- ds50010--------
    rs1410564781,2
    --110834025(+) GTAGAC/GATAGT 1 -- ut310--------
    rs1468950571,2
    --110834083(+) CCTTAC/TAGTAA 1 -- ut310--------
    rs171333221,2
    C,F,H--110834097(+) GTACTA/GTCTTG 1 -- ut3113Minor allele frequency- G:0.07NA NS EA WA 1446

    HapMap Linkage Disequilibrium report for STARD4 (110831731 - 110848288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STARD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518727CNV Gain19592680
    nsv830449CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STARD4 for disorders           About MalaCards
    OMIM gene information: 607049    OMIM disorders: --


    STARD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): STARD4
    Human Genome Epidemiology (HuGE) Navigator: STARD4 (4 documents)

    Export disorders for STARD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STARD4 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with STARD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PubMed id 12011452)1, 2, 3 Soccio R.E....Breslow J.L. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PubMed id 15760897)1, 9 Soccio R.E....Breslow J.L. (2005)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. STARD4 knockdown in HepG2 cells disrupts cholesterol t rafficking associated with the plasma membrane, ER, and ERC. (PubMed id 23033213)1 Garbarino J....Breslow J.L. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. STARD4 abundance regulates sterol transport and sensin g. (PubMed id 21900492)1 Mesmin B....Maxfield F.R. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134429 HGNC: 18058 AceView: STARD4 Ensembl:ENSG00000164211 euGenes: HUgn134429
    ECgene: STARD4 H-InvDB: STARD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STARD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STARD4 gene:
    Search GeneIP for patents involving STARD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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