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Aliases for STARD4 Gene

Aliases for STARD4 Gene

  • StAR Related Lipid Transfer Domain Containing 4 2 3 5
  • START Domain Containing 4, Sterol Regulated 2
  • START Domain-Containing Protein 4 4
  • StARD4 4

External Ids for STARD4 Gene

Previous GeneCards Identifiers for STARD4 Gene

  • GC05M110457
  • GC05M111277
  • GC05M110864
  • GC05M110910
  • GC05M110861
  • GC05M106012

Summaries for STARD4 Gene

Entrez Gene Summary for STARD4 Gene

  • Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

GeneCards Summary for STARD4 Gene

STARD4 (StAR Related Lipid Transfer Domain Containing 4) is a Protein Coding gene. Among its related pathways are Metabolism of steroid hormones and Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF). GO annotations related to this gene include lipid binding. An important paralog of this gene is STARD5.

UniProtKB/Swiss-Prot for STARD4 Gene

  • May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Wiki entry for STARD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD4 Gene

Genomics for STARD4 Gene

Regulatory Elements for STARD4 Gene

Enhancers for STARD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around STARD4 on UCSC Golden Path with GeneCards custom track

Promoters for STARD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STARD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for STARD4 Gene

Chromosome:
5
Start:
111,496,033 bp from pter
End:
111,512,590 bp from pter
Size:
16,558 bases
Orientation:
Minus strand

Genomic View for STARD4 Gene

Genes around STARD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD4 Gene

Proteins for STARD4 Gene

  • Protein details for STARD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR4-STAR4_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 4
    Protein Accession:
    Q96DR4
    Secondary Accessions:
    • Q86TN9

    Protein attributes for STARD4 Gene

    Size:
    205 amino acids
    Molecular mass:
    23517 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STARD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD4 Gene

Post-translational modifications for STARD4 Gene

  • Ubiquitination at Lys 13 and Lys 28
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STARD4 Gene

Domains & Families for STARD4 Gene

Gene Families for STARD4 Gene

Protein Domains for STARD4 Gene

Suggested Antigen Peptide Sequences for STARD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DR4

UniProtKB/Swiss-Prot:

STAR4_HUMAN :
  • Contains 1 START domain.
Domain:
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD4: view

Function for STARD4 Gene

Molecular function for STARD4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Ontology (GO) - Molecular Function for STARD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0015485 cholesterol binding IDA 18403318
genes like me logo Genes that share ontologies with STARD4: view
genes like me logo Genes that share phenotypes with STARD4: view

Animal Models for STARD4 Gene

MGI Knock Outs for STARD4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD4 Gene

Localization for STARD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD4 Gene COMPARTMENTS Subcellular localization image for STARD4 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STARD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic, membrane-bounded vesicle IDA 21767660
genes like me logo Genes that share ontologies with STARD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STARD4 Gene

Pathways & Interactions for STARD4 Gene

genes like me logo Genes that share pathways with STARD4: view

Interacting Proteins for STARD4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296632%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000296632 Q96DR4-STAR4_HUMAN for STARD4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for STARD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0010873 positive regulation of cholesterol esterification IDA 18403318
GO:0070859 positive regulation of bile acid biosynthetic process IDA 18403318
genes like me logo Genes that share ontologies with STARD4: view

No data available for SIGNOR curated interactions for STARD4 Gene

Drugs & Compounds for STARD4 Gene

(1) Drugs for STARD4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for STARD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STARD4: view

Transcripts for STARD4 Gene

Unigene Clusters for STARD4 Gene

StAR-related lipid transfer (START) domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - -
SP8: - -
SP9: - - - - - - -
SP10: - - -
SP11:

Relevant External Links for STARD4 Gene

GeneLoc Exon Structure for
STARD4
ECgene alternative splicing isoforms for
STARD4

Expression for STARD4 Gene

mRNA expression in normal human tissues for STARD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD4 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STARD4 Gene



Protein tissue co-expression partners for STARD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD4 Gene:

STARD4

SOURCE GeneReport for Unigene cluster for STARD4 Gene:

Hs.93842
genes like me logo Genes that share expression patterns with STARD4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STARD4 Gene

Orthologs for STARD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD4 34
  • 90.24 (n)
  • 88.78 (a)
STARD4 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD4 34
  • 87.48 (n)
  • 86.34 (a)
STARD4 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard4 34
  • 85.69 (n)
  • 86.83 (a)
Stard4 16
Stard4 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD4 34
  • 99.67 (n)
  • 99.51 (a)
STARD4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard4 34
  • 84.72 (n)
  • 88.78 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia STARD4 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD4 34
  • 72.03 (n)
  • 75.61 (a)
STARD4 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD4 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490743 34
  • 65.17 (n)
  • 66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18908 34
zebrafish
(Danio rerio)
Actinopterygii zgc:112466 34
  • 60.23 (n)
  • 60.4 (a)
STARD4 35
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for STARD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD4 Gene

ENSEMBL:
Gene Tree for STARD4 (if available)
TreeFam:
Gene Tree for STARD4 (if available)

Paralogs for STARD4 Gene

Paralogs for STARD4 Gene

(3) SIMAP similar genes for STARD4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with STARD4: view

Variants for STARD4 Gene

Sequence variations from dbSNP and Humsavar for STARD4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1643539 -- 111,503,564(-) GCAGC(C/T)TCCGA intron-variant
rs1643540 -- 111,503,552(-) tacct(A/G)gttca intron-variant
rs368896 -- 111,501,722(+) TTAAG(C/G)AGCAA intron-variant
rs2059040 -- 111,498,639(-) CTTTT(C/T)TAAAT nc-transcript-variant, utr-variant-3-prime
rs2059041 -- 111,498,481(-) AGAGT(A/G)GGAAG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for STARD4 Gene

Variant ID Type Subtype PubMed ID
nsv518727 CNV gain 19592680
nsv830449 CNV gain+loss 17160897
nsv950113 CNV duplication 24416366

Variation tolerance for STARD4 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD4 Gene

Disorders for STARD4 Gene

Relevant External Links for STARD4

Genetic Association Database (GAD)
STARD4
Human Genome Epidemiology (HuGE) Navigator
STARD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD4

No disorders were found for STARD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD4 Gene

Publications for STARD4 Gene

  1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PMID: 12011452) Soccio R.E. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PMID: 15760897) Soccio R.E. … Breslow J.L. (J. Biol. Chem. 2005) 3 22 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for STARD4 Gene

Sources for STARD4 Gene

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