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STARD4 Gene

protein-coding   GIFtS: 53
GCID: GC05M110861

StAR-Related Lipid Transfer (START) Domain Containing 4

(Previous names: START domain containing 4, sterol regulated)
  Search for STARD4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
StAR-Related Lipid Transfer (START) Domain Containing 41 2
START Domain Containing 4, Sterol Regulated1 2
START Domain-Containing Protein 42 3
StAR-Related Lipid Transfer Protein 42
START Domain Containing 4 Sterol-Regulated2
StARD43

External Ids:    HGNC: 180581   Entrez Gene: 1344292   Ensembl: ENSG000001642117   OMIM: 6070495   UniProtKB: Q96DR43   

Export aliases for STARD4 gene to outside databases

Previous GC identifers: GC05M110457 GC05M111277 GC05M110864 GC05M110910 GC05M106012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STARD4 Gene:
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g.,
SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive
and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol
biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as
steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing
a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002
(PubMed 12011452)).(supplied by OMIM, Mar 2008)

GeneCards Summary for STARD4 Gene:
STARD4 (StAR-related lipid transfer (START) domain containing 4) is a protein-coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is STARD6.

UniProtKB/Swiss-Prot: STAR4_HUMAN, Q96DR4
Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other
sterols (By similarity)

Gene Wiki entry for STARD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STARD4 gene promoter:
         FOXO3   CUTL1   NF-E2 p45   FOXL1   Gfi-1   FOXO3b   RORalpha1   FOXO3a   NF-E2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTARD4 promoter sequence
   Search Chromatin IP Primers for STARD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STARD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22

STARD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STARD4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M110861:  view genomic region     (about GC identifiers)

Start:
110,831,731 bp from pter      End:
110,848,288 bp from pter
Size:
16,558 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAR4_HUMAN, Q96DR4 (See protein sequence)
Recommended Name: StAR-related lipid transfer protein 4  
Size: 205 amino acids; 23517 Da

Explore the universe of human proteins at neXtProt for STARD4: NX_Q96DR4

Explore proteomics data for STARD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys28
  • Modification sites at PhosphoSitePlus

  • See STARD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_631903.1  
    ENSEMBL proteins: 
     ENSP00000296632   ENSP00000426148   ENSP00000425014   ENSP00000427478   ENSP00000427639  
     ENSP00000425308   ENSP00000407063  
    Reactome Protein details: Q96DR4

    STARD4 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for STARD4

     
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    Cloud-Clone Corp. CLIAs for STARD4
    Search eBioscience for ELISAs for STARD4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    StARD: StAR-related lipid transfer (START) domain containing

    2 InterPro protein domains:
     IPR023393 START-like_dom
     IPR002913 START_lipid-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96DR4

    ProtoNet protein and cluster: Q96DR4

    UniProtKB/Swiss-Prot: STAR4_HUMAN, Q96DR4
    Similarity: Contains 1 START domain


    Find genes that share domains with STARD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAR4_HUMAN, Q96DR4
    Function: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other
    sterols (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with STARD4           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stard4):
     behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system  no phenotypic analysis 

    Find genes that share phenotypes with STARD4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stard4tm1.2Bres for STARD4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STARD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STARD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STARD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STARD4

    miRNA
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    Block miRNA regulation of human, mouse, rat STARD4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate STARD4:
    hsa-miR-3163 hsa-miR-129-3p hsa-miR-938 hsa-miR-3662 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSTARD4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for STARD4
    Predesigned siRNA for gene silencing in human, mouse, rat STARD4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: STARD4 (NM_139164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STARD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STARD4 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    2Metabolism of steroid hormones and vitamin D
    Pregnenolone biosynthesis0.00
    Metabolism of steroid hormones and vitamin D
    3Cholesterol and Sphingolipids transport Distribution to the intracellular membrane compartments normal and CF
    Cholesterol and Sphingolipids transport Distribution to the intracellular membrane compartments normal and CF


    Find genes that share SuperPaths with STARD4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STARD4
        Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

    1 Reactome Pathway for STARD4
        Pregnenolone biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STARD4
    Interactions:

        GeneGlobe Interaction Network for STARD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for STARD4 (ENSP000002966324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    Find genes that share ontologies with STARD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STARD4 (STAR4)

    3 Novoseek inferred chemical compound relationships for STARD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterol 56.7 5 15760897 (3)
    lipid 39.8 5 12011453 (2), 15760897 (1), 15897605 (1)
    cholesterol 39.3 4 15760897 (3), 18211099 (1)



    Find genes that share compounds with STARD4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STARD4 gene: 
    NM_139164.1  

    Unigene Cluster for STARD4:

    StAR-related lipid transfer (START) domain containing 4
    Hs.93842  [show with all ESTs]
    Unigene Representative Sequence: AL832599
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296632(uc003kph.1 uc010jbw.1 uc010jbx.1) ENST00000512160(uc003kpi.1)
    ENST00000511137 ENST00000502931 ENST00000505803 ENST00000502322(uc003kpj.2)
    ENST00000509887 ENST00000511569 ENST00000511436 ENST00000510346 ENST00000455172
    ENST00000508215
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate STARD4:
    hsa-miR-3163 hsa-miR-129-3p hsa-miR-938 hsa-miR-3662 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSTARD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STARD4
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    GenScript: all cDNA clones in your preferred vector: STARD4 (NM_139164)
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    OriGene qPCR primer pairs and template standards for STARD4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STARD4
      QuantiTect SYBR Green Assays in human, mouse, rat STARD4
      QuantiFast Probe-based Assays in human, mouse, rat STARD4

    Additional mRNA sequence: 

    AF480299.1 AK026207.1 AK054566.1 AK125317.1 AK290312.1 AK308851.1 AK310848.1 AK315863.1 
    AK315869.1 AL832599.2 BC019632.1 BC042956.1 

    9 DOTS entries:

    DT.454068  DT.100008098  DT.100789542  DT.91722634  DT.92052567  DT.120846847  DT.102826406  DT.120846864 
    DT.91913018 

    Selected AceView cDNA sequences (see all 135):

    CA443880 BM700581 CB127783 AA256736 AI888300 BU607573 BC042956 AA907326 
    AA252621 BC019632 BP364500 AA808192 AW297675 AK125317 AA125867 AA481998 
    CA430325 AA287449 AA287450 AI439656 D30969 AK054566 CB045787 BQ722914 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STARD4 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -                       -     -     -     -                                 
    SP2:                                      -                       -     -     -     -                                 
    SP3:                                      -                                                                           
    SP4:                                      -     -                 -     -     -     -                                 
    SP5:                          -           -                       -     -     -     -                                 


    ECgene alternative splicing isoforms for STARD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STARD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGTTAAA
    STARD4 Expression
    About this image


    STARD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Oviduct
             Mature follicles
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    STARD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STARD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93842
        Custom PCR Arrays for STARD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for STARD4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stard41 , 5 StAR-related lipid transfer (START) domain containing more1, 5 85.69(n)1
    86.83(a)1
      18 (18.18 cM)5
    1704591  NM_133774.41  NP_598535.11 
     331993555 
    chicken
    (Gallus gallus)
    Aves STARD41 StAR-related lipid transfer (START) domain containing more 72.03(n)
    75.61(a)
      769322  NM_001079742.1  NP_001073210.1 
    lizard
    (Anolis carolinensis)
    Reptilia STARD46
    StAR-related lipid transfer (START) domain contain...
    74(a)
    1 ↔ 1
    GL343193.1(6432183-6442387)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189082 Xenopus laevis transcribed sequence with weak similarity more 74.77(n)    BX849020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1124661 zgc:112466 60.23(n)
    60.4(a)
      550374  NM_001017679.1  NP_001017679.2 


    ENSEMBL Gene Tree for STARD4 (if available)
    TreeFam Gene Tree for STARD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STARD4 gene
    STARD62  STARD52  
    3 SIMAP similar genes for STARD4 using alignment to 6 protein entries:     STAR4_HUMAN (see all proteins):
    DKFZp451B0517    STARD5    STARD6

    Find genes that share paralogs with STARD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STARD4 (see all 237)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838116271,2
    --106028825(+) TGAGGA/GTTTAG 1 -- us2k10--------
    rs1428762701,2
    --110833525(+) TTCCTA/GAGCTT 1 -- ds50010--------
    rs1890364621,2
    --110833848(+) CATCTA/GGAAGC 1 -- ds50010--------
    rs100757621,2
    C,F,H--110833953(+) TCCATG/ATTTAA 1 -- ds500115Minor allele frequency- A:0.02NS EA NA 2082
    rs1824766281,2
    --110833959(+) TTTAAC/TGGTGA 1 -- ds50010--------
    rs1862902071,2
    --110833992(+) GTATAA/TGTTGA 1 -- ds50010--------
    rs1891060261,2
    --110834010(+) AAAGAC/GAGCAC 1 -- ds50010--------
    rs1410564781,2
    --110834025(+) GTAGAC/GATAGT 1 -- ut310--------
    rs1468950571,2
    --110834083(+) CCTTAC/TAGTAA 1 -- ut310--------
    rs171333221,2
    C,F,H--110834097(+) GTACTA/GTCTTG 1 -- ut3113Minor allele frequency- G:0.07NA NS EA WA 1446

    HapMap Linkage Disequilibrium report for STARD4 (110831731 - 110848288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STARD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518727CNV Gain19592680
    nsv830449CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STARD4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607049    OMIM disorders: --


    Find genes that share disorders with STARD4           About GenesLikeMe

    Genetic Association Database (GAD): STARD4
    Human Genome Epidemiology (HuGE) Navigator: STARD4 (4 documents)

    Export disorders for STARD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STARD4 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with STARD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PubMed id 12011452)1, 2, 3 Soccio R.E....Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PubMed id 15760897)1, 9 Soccio R.E....Breslow J.L. (J. Biol. Chem. 2005)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC. (PubMed id 23033213)1 Garbarino J....Breslow J.L. (J. Lipid Res. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. STARD4 abundance regulates sterol transport and sensing. (PubMed id 21900492)1 Mesmin B....Maxfield F.R. (Mol. Biol. Cell 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134429 HGNC: 18058 AceView: STARD4 Ensembl:ENSG00000164211 euGenes: HUgn134429
    ECgene: STARD4 H-InvDB: STARD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STARD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STARD4 gene:
    Search GeneIP for patents involving STARD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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