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Aliases for STARD3NL Gene

Aliases for STARD3NL Gene

  • STARD3 N-Terminal Like 2 3 5
  • STARD3 N-Terminal-Like Protein 3 4
  • MENTHO 3 4
  • MLN64 N-Terminal Domain Homolog 3

External Ids for STARD3NL Gene

Previous GeneCards Identifiers for STARD3NL Gene

  • GC07P037865
  • GC07P037958
  • GC07P037991
  • GC07P038184

Summaries for STARD3NL Gene

Entrez Gene Summary for STARD3NL Gene

  • This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]

GeneCards Summary for STARD3NL Gene

STARD3NL (STARD3 N-Terminal Like) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) and Metabolism of steroid hormones. An important paralog of this gene is STARD3.

Gene Wiki entry for STARD3NL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD3NL Gene

Genomics for STARD3NL Gene

Regulatory Elements for STARD3NL Gene

Enhancers for STARD3NL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G038177 1.1 ENCODE 49.3 +1.1 1147 4.3 PKNOX1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 FOS KLF13 STARD3NL TRGC2
GH07G038215 1.4 Ensembl ENCODE dbSUPER 25.4 +41.1 41111 8.2 ELF3 ATF1 PKNOX1 FOXA2 CBX3 RB1 ARNT ZSCAN4 ZBTB40 RAD21 STARD3NL TRGC2 SFRP4
GH07G038185 0.6 ENCODE 48.3 +8.2 8238 2.1 PKNOX1 EBF1 TBX21 EP300 FOSL1 JUND POLR2A PRDM10 SPI1 STARD3NL TRGC1 TRGC2
GH07G038329 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +152.9 152870 2.6 HDAC1 YBX1 RAD21 ZNF143 IKZF2 CREM CAVIN1 JUNB ELF4 ELF1 ENSG00000272908 STARD3NL TRGV5P TARP TRGV8 TRGV7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STARD3NL on UCSC Golden Path with GeneCards custom track

Promoters for STARD3NL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211095 294 1801 PKNOX1 ZFP64 WRNIP1 SIN3A DMAP1 ZNF143 FOS KLF13 SP3 ZHX2

Genomic Location for STARD3NL Gene

38,178,206 bp from pter
38,230,671 bp from pter
52,466 bases
Plus strand

Genomic View for STARD3NL Gene

Genes around STARD3NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD3NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD3NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD3NL Gene

Proteins for STARD3NL Gene

  • Protein details for STARD3NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MLN64 N-terminal domain homolog
    Protein Accession:
    Secondary Accessions:
    • A4D1X0

    Protein attributes for STARD3NL Gene

    234 amino acids
    Molecular mass:
    26655 Da
    Quaternary structure:
    • Can form homodimers. Interacts with STARD3.

    Alternative splice isoforms for STARD3NL Gene


neXtProt entry for STARD3NL Gene

Post-translational modifications for STARD3NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD3NL Gene

Domains & Families for STARD3NL Gene

Protein Domains for STARD3NL Gene


Suggested Antigen Peptide Sequences for STARD3NL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STARD3NL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STARD3NL Gene

Function for STARD3NL Gene

Gene Ontology (GO) - Molecular Function for STARD3NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015485 cholesterol binding IBA --
genes like me logo Genes that share ontologies with STARD3NL: view
genes like me logo Genes that share phenotypes with STARD3NL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STARD3NL

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STARD3NL Gene

Localization for STARD3NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD3NL Gene

Late endosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD3NL gene
Compartment Confidence
cytosol 5
lysosome 5
endosome 5
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STARD3NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STARD3NL: view

Pathways & Interactions for STARD3NL Gene

genes like me logo Genes that share pathways with STARD3NL: view

Interacting Proteins for STARD3NL Gene

Gene Ontology (GO) - Biological Process for STARD3NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006700 C21-steroid hormone biosynthetic process TAS --
genes like me logo Genes that share ontologies with STARD3NL: view

No data available for SIGNOR curated interactions for STARD3NL Gene

Drugs & Compounds for STARD3NL Gene

No Compound Related Data Available

Transcripts for STARD3NL Gene

Unigene Clusters for STARD3NL Gene

STARD3 N-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD3NL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - - -
SP10: - -

Relevant External Links for STARD3NL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STARD3NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STARD3NL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD3NL Gene

This gene is overexpressed in Breast (20.4), Bone (13.8), Pancreas (12.1), and Fetal Brain (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STARD3NL Gene

Protein tissue co-expression partners for STARD3NL Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD3NL Gene:


SOURCE GeneReport for Unigene cluster for STARD3NL Gene:


Evidence on tissue expression from TISSUES for STARD3NL Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with STARD3NL: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD3NL Gene

Orthologs for STARD3NL Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD3NL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STARD3NL 34 35
  • 99.57 (n)
(Bos Taurus)
Mammalia STARD3NL 34 35
  • 92.88 (n)
(Canis familiaris)
Mammalia STARD3NL 34 35
  • 92.45 (n)
(Ornithorhynchus anatinus)
Mammalia STARD3NL 35
  • 91 (a)
(Mus musculus)
Mammalia Stard3nl 34 16 35
  • 89.03 (n)
(Rattus norvegicus)
Mammalia Stard3nl 34
  • 88.75 (n)
(Monodelphis domestica)
Mammalia STARD3NL 35
  • 78 (a)
(Gallus gallus)
Aves STARD3NL 34 35
  • 80.6 (n)
(Anolis carolinensis)
Reptilia STARD3NL 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stard3nl 34
  • 69.92 (n)
(Danio rerio)
Actinopterygii stard3nl 34 35
  • 66.81 (n)
wufa01c03 34
fruit fly
(Drosophila melanogaster)
Insecta Start1 35
  • 13 (a)
(Caenorhabditis elegans)
Secernentea tag-340 35
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 1 (a)
Species where no ortholog for STARD3NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD3NL Gene

Gene Tree for STARD3NL (if available)
Gene Tree for STARD3NL (if available)

Paralogs for STARD3NL Gene

Paralogs for STARD3NL Gene

(1) SIMAP similar genes for STARD3NL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with STARD3NL: view

Variants for STARD3NL Gene

Sequence variations from dbSNP and Humsavar for STARD3NL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000159862 -- 38,231,061(+) GAATG(C/T)AGTAG downstream-variant-500B
rs1000225633 -- 38,212,773(+) TGATA(A/G)GCCGA intron-variant
rs1000232655 -- 38,187,849(+) TCACT(A/C)AATAG intron-variant
rs1000356124 -- 38,216,173(+) CTATC(C/T)CTCTC intron-variant
rs1000437193 -- 38,226,794(+) TGAGC(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD3NL Gene

Variant ID Type Subtype PubMed ID
dgv89n68 CNV gain 17160897
esv1010248 CNV deletion 20482838
esv2734274 CNV deletion 23290073
esv2759524 CNV loss 17122850
esv2762664 CNV loss 21179565
esv29985 CNV loss 17803354
esv32671 CNV loss 17666407
esv3571746 CNV loss 25503493
nsv1128311 CNV deletion 24896259

Variation tolerance for STARD3NL Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD3NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD3NL Gene

Disorders for STARD3NL Gene

Relevant External Links for STARD3NL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STARD3NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD3NL Gene

Publications for STARD3NL Gene

  1. MENTHO, a MLN64 homologue devoid of the START domain. (PMID: 12393907) Alpy F. … Tomasetto C. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. MLN64 and MENTHO, two mediators of endosomal cholesterol transport. (PMID: 16709157) Alpy F. … Tomasetto C. (Biochem. Soc. Trans. 2006) 3 4 22 64
  3. TouchAc! STARD3 and STARD3NL tether the ER to endosomes. (PMID: 27068960) Wilhelm L.P. … Alpy F. (Biochem. Soc. Trans. 2016) 2 3 64
  4. STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. (PMID: 24105263) Alpy F. … Tomasetto C. (J. Cell. Sci. 2013) 2 3 64
  5. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. (PMID: 22310353) Man M. … Garcia J.G. (Pharmacogenomics J. 2013) 3 46 64

Products for STARD3NL Gene

Sources for STARD3NL Gene

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