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Aliases for STARD3NL Gene

Aliases for STARD3NL Gene

  • STARD3 N-Terminal Like 2 3 5
  • STARD3 N-Terminal-Like Protein 3 4
  • MENTHO 3 4

External Ids for STARD3NL Gene

Previous GeneCards Identifiers for STARD3NL Gene

  • GC07P037865
  • GC07P037958
  • GC07P037991
  • GC07P038184

Summaries for STARD3NL Gene

Entrez Gene Summary for STARD3NL Gene

  • This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). [provided by RefSeq, Sep 2011]

GeneCards Summary for STARD3NL Gene

STARD3NL (STARD3 N-Terminal Like) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF). An important paralog of this gene is STAR.

Gene Wiki entry for STARD3NL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD3NL Gene

Genomics for STARD3NL Gene

Regulatory Elements for STARD3NL Gene

Enhancers for STARD3NL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STARD3NL on UCSC Golden Path with GeneCards custom track

Promoters for STARD3NL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STARD3NL on UCSC Golden Path with GeneCards custom track

Genomic Location for STARD3NL Gene

Chromosome:
7
Start:
38,178,206 bp from pter
End:
38,230,671 bp from pter
Size:
52,466 bases
Orientation:
Plus strand

Genomic View for STARD3NL Gene

Genes around STARD3NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD3NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD3NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD3NL Gene

Proteins for STARD3NL Gene

  • Protein details for STARD3NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95772-MENTO_HUMAN
    Recommended name:
    MLN64 N-terminal domain homolog
    Protein Accession:
    O95772
    Secondary Accessions:
    • A4D1X0

    Protein attributes for STARD3NL Gene

    Size:
    234 amino acids
    Molecular mass:
    26655 Da
    Quaternary structure:
    • Can form homodimers. Interacts with STARD3.

    Alternative splice isoforms for STARD3NL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD3NL Gene

Proteomics data for STARD3NL Gene at MOPED

Post-translational modifications for STARD3NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD3NL Gene

No data available for DME Specific Peptides for STARD3NL Gene

Domains & Families for STARD3NL Gene

Protein Domains for STARD3NL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STARD3NL Gene

Graphical View of Domain Structure for InterPro Entry

O95772

UniProtKB/Swiss-Prot:

MENTO_HUMAN :
  • Contains 1 MENTAL domain.
Domain:
  • Contains 1 MENTAL domain.
genes like me logo Genes that share domains with STARD3NL: view

No data available for Gene Families for STARD3NL Gene

Function for STARD3NL Gene

genes like me logo Genes that share phenotypes with STARD3NL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for STARD3NL

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STARD3NL Gene

Localization for STARD3NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD3NL Gene

Late endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD3NL Gene COMPARTMENTS Subcellular localization image for STARD3NL gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STARD3NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with STARD3NL: view

Pathways & Interactions for STARD3NL Gene

genes like me logo Genes that share pathways with STARD3NL: view

Pathways by source for STARD3NL Gene

Interacting Proteins for STARD3NL Gene

Gene Ontology (GO) - Biological Process for STARD3NL Gene

None

No data available for SIGNOR curated interactions for STARD3NL Gene

Drugs & Compounds for STARD3NL Gene

No Compound Related Data Available

Transcripts for STARD3NL Gene

Unigene Clusters for STARD3NL Gene

STARD3 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD3NL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - - -
SP10: - -
SP11:

Relevant External Links for STARD3NL Gene

GeneLoc Exon Structure for
STARD3NL
ECgene alternative splicing isoforms for
STARD3NL

Expression for STARD3NL Gene

mRNA expression in normal human tissues for STARD3NL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD3NL Gene

This gene is overexpressed in Breast (20.4), Bone (13.8), Pancreas (12.1), and Fetal Brain (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STARD3NL Gene



SOURCE GeneReport for Unigene cluster for STARD3NL Gene Hs.744885

genes like me logo Genes that share expression patterns with STARD3NL: view

Protein tissue co-expression partners for STARD3NL Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STARD3NL Gene

Orthologs for STARD3NL Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD3NL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD3NL 35
  • 92.88 (n)
  • 97.44 (a)
STARD3NL 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD3NL 35
  • 92.45 (n)
  • 94.44 (a)
STARD3NL 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard3nl 35
  • 89.03 (n)
  • 94.44 (a)
Stard3nl 16
Stard3nl 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD3NL 35
  • 99.57 (n)
  • 100 (a)
STARD3NL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard3nl 35
  • 88.75 (n)
  • 95.3 (a)
oppossum
(Monodelphis domestica)
Mammalia STARD3NL 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD3NL 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD3NL 35
  • 80.6 (n)
  • 83.19 (a)
STARD3NL 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD3NL 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard3nl 35
  • 69.92 (n)
  • 72.09 (a)
zebrafish
(Danio rerio)
Actinopterygii stard3nl 35
  • 66.81 (n)
  • 68.44 (a)
wufa01c03 35
stard3nl 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Start1 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-340 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 1 (a)
OneToMany
Species with no ortholog for STARD3NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD3NL Gene

ENSEMBL:
Gene Tree for STARD3NL (if available)
TreeFam:
Gene Tree for STARD3NL (if available)

Paralogs for STARD3NL Gene

Paralogs for STARD3NL Gene

(1) SIMAP similar genes for STARD3NL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with STARD3NL: view

Variants for STARD3NL Gene

Sequence variations from dbSNP and Humsavar for STARD3NL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1014136 -- 38,189,505(-) CTTCA(C/T)TTGTT intron-variant
rs1019179 -- 38,179,374(+) ACAAT(A/G)TGTTG intron-variant
rs1019180 -- 38,179,410(+) ATCTA(A/T)CTGTC intron-variant
rs6959603 -- 38,217,337(+) TGAGG(C/T)GGACT intron-variant
rs6962982 -- 38,199,073(+) TCAGA(A/G)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD3NL Gene

Variant ID Type Subtype PubMed ID
dgv89n68 CNV Gain 17160897
dgv2076e1 CNV Complex 17122850
esv32671 CNV Loss 17666407
esv1010248 CNV Deletion 20482838
esv2734274 CNV Deletion 23290073
esv29985 CNV Loss 17803354

Variation tolerance for STARD3NL Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STARD3NL Gene

Disorders for STARD3NL Gene

Relevant External Links for STARD3NL

Genetic Association Database (GAD)
STARD3NL
Human Genome Epidemiology (HuGE) Navigator
STARD3NL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD3NL

No disorders were found for STARD3NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD3NL Gene

Publications for STARD3NL Gene

  1. MENTHO, a MLN64 homologue devoid of the START domain. (PMID: 12393907) Alpy F. … Tomasetto C. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. MLN64 and MENTHO, two mediators of endosomal cholesterol transport. (PMID: 16709157) Alpy F. … Tomasetto C. (Biochem. Soc. Trans. 2006) 3 23
  3. Functional characterization of the MENTAL domain. (PMID: 15718238) Alpy F. … Tomasetto C. (J. Biol. Chem. 2005) 3 23
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. (PMID: 22310353) Man M. … Garcia J.G. (Pharmacogenomics J. 2013) 3

Products for STARD3NL Gene

Sources for STARD3NL Gene

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