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Aliases for STARD3 Gene

Aliases for STARD3 Gene

  • StAR Related Lipid Transfer Domain Containing 3 2 3 5
  • Metastatic Lymph Node Gene 64 Protein 3 4
  • START Domain-Containing Protein 3 3 4
  • MLN 64 3 4
  • MLN64 3 4
  • CAB1 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 3 3
  • StAR-Related Lipid Transfer Domain Containing 3 3
  • Steroidogenic Acute Regulatory Protein Related 3
  • Metastatic Lymph Node Protein 64 3
  • START Domain Containing 3 2
  • Protein CAB1 4
  • StARD3 4
  • Es64 3

External Ids for STARD3 Gene

Previous GeneCards Identifiers for STARD3 Gene

  • GC17P037292
  • GC17P039791
  • GC17P037703
  • GC17P038168
  • GC17P035046
  • GC17P037793
  • GC17P033587

Summaries for STARD3 Gene

Entrez Gene Summary for STARD3 Gene

  • This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for STARD3 Gene

STARD3 (StAR Related Lipid Transfer Domain Containing 3) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF). GO annotations related to this gene include lipid binding and cholesterol transporter activity. An important paralog of this gene is STAR.

UniProtKB/Swiss-Prot for STARD3 Gene

  • Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD3 Gene

Genomics for STARD3 Gene

Regulatory Elements for STARD3 Gene

Enhancers for STARD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STARD3 on UCSC Golden Path with GeneCards custom track

Promoters for STARD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STARD3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the STARD3 gene promoter:

Genomic Location for STARD3 Gene

Chromosome:
17
Start:
39,637,065 bp from pter
End:
39,664,201 bp from pter
Size:
27,137 bases
Orientation:
Plus strand

Genomic View for STARD3 Gene

Genes around STARD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD3 Gene

Proteins for STARD3 Gene

  • Protein details for STARD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14849-STAR3_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 3
    Protein Accession:
    Q14849
    Secondary Accessions:
    • A8MXA4
    • B4DUY1
    • F5H0G2
    • Q53Y53
    • Q96HM9

    Protein attributes for STARD3 Gene

    Size:
    445 amino acids
    Molecular mass:
    50502 Da
    Quaternary structure:
    • Can form homodimers. Interacts with STARD3NL.

    Three dimensional structures from OCA and Proteopedia for STARD3 Gene

    Alternative splice isoforms for STARD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD3 Gene

Proteomics data for STARD3 Gene at MOPED

Post-translational modifications for STARD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD3 Gene

Domains & Families for STARD3 Gene

Gene Families for STARD3 Gene

Suggested Antigen Peptide Sequences for STARD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14849

UniProtKB/Swiss-Prot:

STAR3_HUMAN :
  • Contains 1 MENTAL domain.
Domain:
  • Contains 1 MENTAL domain.
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD3: view

Function for STARD3 Gene

Molecular function for STARD3 Gene

UniProtKB/Swiss-Prot Function:
Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.

Gene Ontology (GO) - Molecular Function for STARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24105263
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD3: view
genes like me logo Genes that share phenotypes with STARD3: view

Animal Models for STARD3 Gene

MGI Knock Outs for STARD3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD3 Gene

Localization for STARD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD3 Gene

Late endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD3 Gene COMPARTMENTS Subcellular localization image for STARD3 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
mitochondrion 3
plasma membrane 3
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9139840
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with STARD3: view

Pathways & Interactions for STARD3 Gene

genes like me logo Genes that share pathways with STARD3: view

Pathways by source for STARD3 Gene

Interacting Proteins for STARD3 Gene

Gene Ontology (GO) - Biological Process for STARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006839 mitochondrial transport TAS 9270027
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with STARD3: view

No data available for SIGNOR curated interactions for STARD3 Gene

Drugs & Compounds for STARD3 Gene

(2) Drugs for STARD3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for STARD3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STARD3: view

Transcripts for STARD3 Gene

Unigene Clusters for STARD3 Gene

StAR-related lipid transfer (START) domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - -
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - -
SP18:
SP19: - - - - - - -
SP20:
SP21:
SP22:
SP23: - - - - - -
SP24:

ExUns: 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:

ExUns: 17b ^ 18
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for STARD3 Gene

GeneLoc Exon Structure for
STARD3
ECgene alternative splicing isoforms for
STARD3

Expression for STARD3 Gene

mRNA expression in normal human tissues for STARD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD3 Gene

This gene is overexpressed in Plasma (20.4), Lung (19.0), and Cervix (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STARD3 Gene



SOURCE GeneReport for Unigene cluster for STARD3 Gene Hs.728838

genes like me logo Genes that share expression patterns with STARD3: view

Protein tissue co-expression partners for STARD3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STARD3 Gene

Orthologs for STARD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STARD3 35
  • 90.86 (n)
  • 95.28 (a)
STARD3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD3 35
  • 91.57 (n)
  • 95.94 (a)
STARD3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard3 35
  • 88.39 (n)
  • 93.71 (a)
Stard3 16
Stard3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STARD3 35
  • 98.58 (n)
  • 97.98 (a)
STARD3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard3 35
  • 88.31 (n)
  • 93.03 (a)
oppossum
(Monodelphis domestica)
Mammalia STARD3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD3 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD3 35
  • 76.37 (n)
  • 81.49 (a)
STARD3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard3 35
  • 70.98 (n)
  • 73.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68989 35
zebrafish
(Danio rerio)
Actinopterygii mln64-pen 35
stard3 35
  • 67.82 (n)
  • 72.7 (a)
stard3 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007057 35
  • 49.48 (n)
  • 39.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Start1 35
  • 48.85 (n)
  • 35.64 (a)
Start1 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-340 35
  • 41.76 (n)
  • 30.65 (a)
tag-340 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for STARD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD3 Gene

ENSEMBL:
Gene Tree for STARD3 (if available)
TreeFam:
Gene Tree for STARD3 (if available)

Paralogs for STARD3 Gene

Paralogs for STARD3 Gene

Pseudogenes.org Pseudogenes for STARD3 Gene

genes like me logo Genes that share paralogs with STARD3: view

Variants for STARD3 Gene

Sequence variations from dbSNP and Humsavar for STARD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1877031 - 39,657,827(-) GGAGC(C/T)GCAGC nc-transcript-variant, reference, missense
rs11556624 - 39,659,051(+) TGCAG(C/G)GTCTG nc-transcript-variant, reference, missense
rs8442 -- 39,661,060(+) GTGCC(C/T)AGCCC nc-transcript-variant, downstream-variant-500B, reference, missense, stop-gained
rs15968 -- 39,663,082(-) GTCCA(C/G)TGCTC nc-transcript-variant, utr-variant-3-prime
rs427103 -- 39,645,882(-) aaaaa(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD3 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV Loss 17160897
nsv521294 CNV Loss 19592680
dgv3162n71 CNV Loss 21882294
nsv908207 CNV Loss 21882294
nsv2047 CNV Insertion 18451855
nsv457738 CNV Loss 19166990
nsv516757 CNV Loss 19592680
nsv908213 CNV Loss 21882294
nsv528093 CNV Loss 19592680
nsv908214 CNV Loss 21882294
nsv908215 CNV Loss 21882294

Variation tolerance for STARD3 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.10; 96.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STARD3 Gene

Disorders for STARD3 Gene

Relevant External Links for STARD3

Genetic Association Database (GAD)
STARD3
Human Genome Epidemiology (HuGE) Navigator
STARD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD3

No disorders were found for STARD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD3 Gene

Publications for STARD3 Gene

  1. The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein. (PMID: 11053434) Alpy F. … Rio M.-C. (J. Biol. Chem. 2001) 3 4 23 67
  2. Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages. (PMID: 19272380) Borthwick F. … Graham A. (FEBS Lett. 2009) 3 23
  3. Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer (START) domains of StAR (STARD1) and MLN64 (STARD3). (PMID: 18331352) Reitz J. … Gimpl G. (FEBS J. 2008) 3 23
  4. MLN64 and MENTHO, two mediators of endosomal cholesterol transport. (PMID: 16709157) Alpy F. … Tomasetto C. (Biochem. Soc. Trans. 2006) 3 23
  5. Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol. (PMID: 16990645) Murcia M. … Roux B. (J. Lipid Res. 2006) 3 23

Products for STARD3 Gene

Sources for STARD3 Gene

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