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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STARD13 Gene

protein-coding GIFtS: 57
GCID: GC13M033677

StAR-related lipid transfer (START) domain containing 13

(Previous names: START domain containing 13, long intergenic non-protein...)
(Previous symbol: LINC00464)

Explore 10 diseases affiliated with
STARD13 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
StAR-Related Lipid Transfer (START) Domain Containing 13¹ ²		DLC-2² ³
DLC2¹ ² ³ ⁵		START Domain Containing 13¹
GT650¹ ² ³		Rho GTPase Activating Protein On Chromosome 13q12²
ARHGAP37¹ ²		StAR-Related Lipid Transfer Protein 13²
LINC00464¹ ²		StARD13³
Long Intergenic Non-Protein Coding RNA 464¹ ²		Rho GTPase-Activating Protein³
Deleted In Liver Cancer 2 Protein² ³		START Domain-Containing Protein 13³
46H23.2² ³

External Ids:	HGNC: 19164¹	Entrez Gene: 90627²	Ensembl: ENSG00000133121⁷	OMIM: 609866⁵	UniProtKB: Q9Y3M8³

Export aliases for STARD13 gene to outside databases

Previous GC identifers: GC13M031663 GC13M027663 GC13M032613 GC13M031475 GC13M032575 GC13M014489

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STARD13:

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions,

followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid

transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell

motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is

associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants

encoding different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8

Function: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal

reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells

Gene Wiki entry for STARD13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STARD13 gene promoter:
E2F-4 E2F-3a E2F-1 E2F E2F-2 CUTL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STARD13 promoter sequence

Search SABiosciences Chromatin IP Primers for STARD13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STARD13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12-q13 Ensembl cytogenetic band: 13q13.1 HGNC cytogenetic band: 13q12-q13

STARD13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STARD13 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M033677: view genomic region (about GC identifiers)

Start:	33,677,272 bp from pter	End:	33,924,767 bp from pter
Size:	247,496 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8 (See protein sequence)

Recommended Name: StAR-related lipid transfer protein 13

Size: 1113 amino acids; 124967 Da

Subunit: Homodimer. Interacts with TAX1BP1

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane;

Peripheral membrane protein; Cytoplasmic side. Lipid droplet

3 PDB 3D structures from and Proteopedia for STARD13:

2H80 (3D)

2JW2 (3D)

2PSO (3D)

Secondary accessions: A2A309 A2A310 Q5HYH1 Q5TAE3 Q6UN61 Q86TP6 Q86WQ3 Q86XT1

Alternative splicing: 5 isoforms: Q9Y3M8-1 Q9Y3M8-2 Q9Y3M8-3 Q9Y3M8-4 Q9Y3M8-5

Explore the universe of human proteins at neXtProt for STARD13: NX_Q9Y3M8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y3M8

STARD13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001230395.1 NP_001230403.1 NP_001230405.1 NP_443083.1 NP_821074.1 NP_821075.1

ENSEMBL proteins:

ENSP00000255486 ENSP00000382300 ENSP00000338785 ENSP00000456233 ENSP00000457840

Reactome Protein details: Q9Y3M8
Human Recombinant Protein Products for STARD13:

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	Novus Biologicals STARD13 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STARD13

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005811	lipid particle	IEA	--
GO:0005829	cytosol	TAS	--
GO:0031966	mitochondrial membrane	IEA	--

STARD13 for ontologies About GeneDecksing

STARD13 Antibody Products:

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Assay Products for STARD13:

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	Uscn ELISAs and CLIAs for STARD13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STARD13 for domains About GeneDecksing

5 InterPro domains/families:

IPR011510 SAM_2

IPR023393 START-like_dom

IPR008936 Rho_GTPase_activation_prot

IPR002913 START_lipid-bd_dom

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q9Y3M8

ProtoNet protein and cluster: Q9Y3M8

3 Blocks protein families:

IPB000198 RhoGAP domain

IPB002913 Lipid-binding START

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

Similarity: Contains 1 START domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STA13_HUMAN, Q9Y3M8

Function: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal

reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	14697242

STARD13 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for STARD13:

High actin ratio cells

10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Stard13):

adipose tissue	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	mortality/aging	tumorigenesis

STARD13 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for STARD13: Stard13^tm1.2Fms Stard13^tm1Ioln

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STARD13

miRNA Products:		OriGene 3'-UTR Clone (see all 3): STARD13 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STARD13
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate STARD13 (see all 88):
		hsa-miR-3938 hsa-miR-15a hsa-miR-877* hsa-miR-298 hsa-miR-200b hsa-miR-92b hsa-miR-130b hsa-miR-374b*

		SwitchGear 3'UTR luciferase reporter plasmid: STARD13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STARD13 (see all 7) OriGene shRNA RFP: STARD13 OriGene siRNA: STARD13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STARD13
		Sirion Biotech Custom design and validation of potent shRNA sequences against STARD13

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for STARD13
			Sirion Biotech Customized adenovirus for overexpression of STARD13 Sirion Biotech Customized adenovirus for potent knockdown of STARD13

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STARD13 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STARD13 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): STARD13 (NM_052851)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STARD13
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		Sirion Biotech Customized stable knockdown cell line services for STARD13 Sirion Biotech Customized inducible knockdown cell line services for STARD13 Sirion Biotech Customized stable overexpressing cell line services for STARD13 Sirion Biotech Customized inducible overexpressing cell line services for STARD13

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD13

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for STARD13

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

STARD13 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STARD13

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/18 Interacting proteins for STARD13 (Q9Y3M8^{1, 2, 3} ENSP00000338785⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAX1BP1	Q86VP1¹^,³, ENSP00000379612⁴	EBI-465487,EBI-529518 I2D: score=5 STRING: ENSP00000379612
SMAD1	Q15797²^,³	MINT-62010 I2D: score=3
EPB41L1	Q9H4G0³, ENSP00000337168⁴	I2D: score=5 STRING: ENSP00000337168
CNTN2	Q02246³, ENSP00000330633⁴	I2D: score=1 STRING: ENSP00000330633
BAI2	O60241³, ENSP00000362762⁴	I2D: score=5 STRING: ENSP00000362762

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	--

STARD13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STARD13
Search CenterWatch for drugs/clinical trials and news about STARD13 / STA13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STARD13 gene (7 alternative transcripts):

NM_001243466.1 NM_001243474.1 NM_001243476.1 NM_052851.2 NM_178006.3 NM_178007.2 NM_178008.1

Unigene Cluster for STARD13:

StAR-related lipid transfer (START) domain containing 13

Hs.507704 [show with all ESTs]

Unigene Representative Sequence: NM_001243476

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000255486(uc001uuu.3 uc021rhz.1) ENST00000399365(uc001uuv.3 uc001uux.3 uc021ria.1)

ENST00000336934(uc001uuw.3) ENST00000491333 ENST00000567873(uc010abh.1)

ENST00000487412 ENST00000498019 ENST00000439831

miRNA Products:		OriGene 3'-UTR Clone (see all 3): STARD13 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STARD13
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate STARD13 (see all 88):
		hsa-miR-3938 hsa-miR-15a hsa-miR-877* hsa-miR-298 hsa-miR-200b hsa-miR-92b hsa-miR-130b hsa-miR-374b*

		SwitchGear 3'UTR luciferase reporter plasmid: STARD13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STARD13 (see all 7) OriGene shRNA RFP: STARD13 OriGene siRNA: STARD13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STARD13
		Sirion Biotech Custom design and validation of potent shRNA sequences against STARD13

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STARD13 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STARD13 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): STARD13 (NM_052851)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STARD13 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STARD13
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD13

Additional cDNA sequence:

AK091804.1 AK094704.1 AK095114.1 AK308430.1 AK308453.1 AK312888.1 AL049801.1 AY082589.1

AY082590.1 AY082591.1 AY082592.1 AY366448.1 BC046563.1 BX641149.1 BX647695.1

14 DOTS entries:

DT.102831428 DT.100766864 DT.315494 DT.100714251 DT.100766865 DT.101981886 DT.100766860 DT.101981884

DT.40131005 DT.40251259 DT.207700 DT.97812694 DT.92004352 DT.92021481

24/164 AceView cDNA sequences (see all 164):

AA568180 BU180161 AI082579 AW474925 BM713913 BQ691857 BE293955 BE349319

AW295469 CA445183 BF059253 BI906055 AW628581 AW014281 AI381181 AK095114

H53015 H49574 CA389255 BX118018 NM_052851 CR597966 AY082591 BQ688299

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for STARD13 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	·	15c	·	15d	^	16	^	17	^	18a	·
SP1:									-		-		-		-		-						-		-				-														-		-
SP2:																							-		-				-														-		-
SP3:									-		-		-		-		-						-		-				-														-		-
SP4:																	-						-		-				-														-		-
SP5:																							-		-				-										-

ExUns:	18b	^	19a	·	19b	^	20	^	21	^	22a	·	22b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for STARD13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STARD13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATTTTTA

About this image

STARD13 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STARD13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STARD13

SOURCE GeneReport for Unigene cluster: Hs.507704

UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8

Tissue specificity: Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer

cell lines

SABiosciences Custom PCR Arrays for STARD13

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STARD13 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STARD13

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for STARD13 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STARD13¹	StAR-related lipid transfer (START) domain containing more	75.79(n) 79.35(a)		418908 XM_417104.3 XP_417104.2
lizard (Anolis carolinensis)	Reptilia	STARD13⁶	--	74(a)	1 ↔ 1	GL344040.1(22036-64435)
African clawed frog (Xenopus laevis)	Amphibia	BJ631133.1²	--	75.14(n)		BJ631133.1
zebrafish (Danio rerio)	Actinopterygii	BI562852.1²	--	78.81(n)		BI562852.1
fruit fly (Drosophila melanogaster)	Insecta	cv-c¹	crossveinless c	52.3(n) 45.16(a)		41749 NM_001104316.1 NP_001097786.1
worm (Caenorhabditis elegans)	Secernentea	gei-1⁶	GEX Interacting protein family member (gei-1)	15(a)	1 → many	III(3344867-3363419)

ENSEMBL Gene Tree for STARD13 (if available)
TreeFam Gene Tree for STARD13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STARD13 gene

ARHGAP36² ARHGAP6² ARHGAP40² ARHGAP18² ARHGAP11A² DLC1² ARHGAP28² ARHGAP11B²

STARD8²

3 SIMAP similar genes for STARD13 using alignment to 4 protein entries: STA13_HUMAN (see all proteins):

DKFZp686I04252 DLC1 STARD8

STARD13 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7330351^1,2	C,H	--	14488848(+)	`TTTAAG/AGACAA`	4	--	ds500¹		5	NS EA CSA	420
rs74637050^1,2	F	--	14489087(+)	`TTTTAT/CAGAAA`	4	--	ut3¹		1	WA	118
rs486763^1,2	C,F,H	--	14489181(-)	`TGTATA/CTTTTT`	4	--	ut3¹ ese³		7	MN NS EA NA WA	710
rs1325362^1,2	C,F,O,H	--	14489796(-)	`CTTCTG/TCCATA`	4	--	ut3¹ ese³		14	MN NA NS EA WA	1254
rs117848662^1,2	C,F	--	14490326(+)	`NNNNTC/TTAAAA`	4	--	ut3¹		1	NA	120
rs113768203^1,2		--	14490476(+)	`TTGAAC/TGGAAT`	4	--	ut3¹		1	CSA	2
rs9568845^1,2	C,H	--	14490523(+)	`ATTCAG/ATGCAA`	4	--	ut3¹		4	NS EA	420
rs61941365^1,2		--	14490924(+)	`AAAGCG/ATTAAC`	4	--	ut3¹		1	NA	2
rs7991053^1,2	C,F,H	--	14490937(+)	`ATAAGT/ACTCCT`	4	--	ut3¹ ese³		8	NS EA NA WA	544
rs79417570^1,2	C,F	--	14491069(+)	`ACTTGG/AAAAGA`	4	--	ut3¹		1	WA	118

HapMap Linkage Disequilibrium report for STARD13 (33677272 - 33924767 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STARD13
1 CNV: 101697
2 Indels: 45159 58622

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STARD13 for disorders           About GeneDecksing

OMIM gene information: 609866    OMIM disorders: --

10 diseases for STARD13:    About MalaCards

hepatocellular carcinoma liver cancer carcinoma intellectual disability

intrahepatic cholangiocarcinoma fibrosarcoma of bone fibrosarcoma cholangiocarcinoma

breast carcinoma breast cancer

1 disease from the University of Copenhagen DISEASES database for STARD13:

Intellectual disability

2 Novoseek disease relationships for STARD13 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	53.6	4	18651974 (3), 17016643 (1)
tumors	14.2	8	17016643 (3), 12531887 (2), 16217026 (2), 18651974 (1)

Human Genome Epidemiology (HuGE) Navigator: STARD13 (6 documents)

Export disorders for STARD13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STARD13 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with STARD13)

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Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. (PubMed id 12531887)^{1, 2, 9} Ching Y.-P.... Ng I.O. (2003)
Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. (PubMed id 16217026)^{1, 2, 9} Leung T.H.-Y.... Ng I.O. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)^{1, 2} Nagaraja G.M. and Kandpal R.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)^{1, 3} Couch F.J.... Simard J. (1996)
Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma. (PubMed id 18651974)^{1, 9} Xiaorong L....Kaiyan Y. (2008)
Rho signalling restriction by the RhoGAP Stard13 integ rates growth and morphogenesis in the pancreas. (PubMed id 23175628)¹ Petzold K.M....Spagnoli F.M. (2013)
MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. (PubMed id 22693547)¹ Tang F....Xi T. (2012)
DLC2/StarD13 plays a role of a tumor suppressor in ast rocytoma. (PubMed id 22614672)¹ El-Sitt S....El-Sibai M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90627	HGNC: 19164	AceView: STARD13	Ensembl:ENSG00000133121	euGenes: HUgn90627
ECgene: STARD13	H-InvDB: STARD13

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STARD13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STARD13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STARD13 gene:
Search GeneIP for patents involving STARD13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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StAR-related lipid transfer (START) domain containing 13

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STARD13 Gene

StAR-related lipid transfer (START) domain containing 13

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