Aliases for STARD13 Gene
External Ids for STARD13 Gene
Previous HGNC Symbols for STARD13 Gene
Previous GeneCards Identifiers for STARD13 Gene
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for STARD13 Gene
STARD13 (StAR-Related Lipid Transfer (START) Domain Containing 13) is a Protein Coding gene. Diseases associated with STARD13 include fibrosarcoma of bone and intracranial aneurysm. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and lipid binding. An important paralog of this gene is ARHGAP11A.
UniProtKB/Swiss-Prot for STARD13 Gene
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.