Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STARD13 Gene

Aliases for STARD13 Gene

  • StAR-Related Lipid Transfer (START) Domain Containing 13 2 3
  • Dlc2 3 4 6
  • Long Intergenic Non-Protein Coding RNA 464 2 3
  • Deleted In Liver Cancer 2 Protein 3 4
  • GT650 3 4
  • Rho GTPase Activating Protein On Chromosome 13q12 3
  • StAR-Related Lipid Transfer Protein 13 3
  • START Domain-Containing Protein 13 4
  • Rho GTPase-Activating Protein 4
  • START Domain Containing 13 2
  • LINC00464 3
  • ARHGAP37 3
  • 46H23.2 4
  • StARD13 4
  • DLC-2 4

External Ids for STARD13 Gene

Previous HGNC Symbols for STARD13 Gene

  • LINC00464

Previous GeneCards Identifiers for STARD13 Gene

  • GC13M031663
  • GC13M027663
  • GC13M032613
  • GC13M031475
  • GC13M032575
  • GC13M033677
  • GC13M014489

Summaries for STARD13 Gene

Entrez Gene Summary for STARD13 Gene

  • This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for STARD13 Gene

STARD13 (StAR-Related Lipid Transfer (START) Domain Containing 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for STARD13 Gene

  • GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.

Gene Wiki entry for STARD13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD13 Gene

Genomics for STARD13 Gene

Regulatory Elements for STARD13 Gene

Genomic Location for STARD13 Gene

Start:
33,103,135 bp from pter
End:
33,676,807 bp from pter
Size:
573,673 bases
Orientation:
Minus strand

Genomic View for STARD13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STARD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD13 Gene

Proteins for STARD13 Gene

  • Protein details for STARD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3M8-STA13_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 13
    Protein Accession:
    Q9Y3M8
    Secondary Accessions:
    • A2A309
    • A2A310
    • Q5HYH1
    • Q5TAE3
    • Q6UN61
    • Q86TP6
    • Q86WQ3
    • Q86XT1

    Protein attributes for STARD13 Gene

    Size:
    1113 amino acids
    Molecular mass:
    124967 Da
    Quaternary structure:
    • Homodimer. Interacts with TAX1BP1.

    Three dimensional structures from OCA and Proteopedia for STARD13 Gene

    Alternative splice isoforms for STARD13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD13 Gene

Proteomics data for STARD13 Gene at MOPED

Post-translational modifications for STARD13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD13 Gene

No data available for DME Specific Peptides for STARD13 Gene

Domains for STARD13 Gene

Gene Families for STARD13 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • StARD :StAR-related lipid transfer (START) domain containing

Graphical View of Domain Structure for InterPro Entry

Q9Y3M8

UniProtKB/Swiss-Prot:

STA13_HUMAN :
  • Q9Y3M8
Domain:
  • Contains 1 Rho-GAP domain.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 START domain.
genes like me logo Genes that share domains with STARD13: view

Function for STARD13 Gene

Molecular function for STARD13 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.

Gene Ontology (GO) - Molecular Function for STARD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 14697242
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD13: view
genes like me logo Genes that share phenotypes with STARD13: view

Animal Models for STARD13 Gene

MGI Knock Outs for STARD13:

miRNA for STARD13 Gene

miRTarBase miRNAs that target STARD13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STARD13 Gene

Localization for STARD13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD13 Gene

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STARD13 Gene COMPARTMENTS Subcellular localization image for STARD13 gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 3
cytoskeleton 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for STARD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005811 lipid particle IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with STARD13: view

Pathways for STARD13 Gene

genes like me logo Genes that share pathways with STARD13: view

Pathways by source for STARD13 Gene

3 Reactome pathways for STARD13 Gene

Gene Ontology (GO) - Biological Process for STARD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with STARD13: view

Transcripts for STARD13 Gene

Unigene Clusters for STARD13 Gene

StAR-related lipid transfer (START) domain containing 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STARD13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9:
SP10: - -
SP11:
SP12: -

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for STARD13 Gene

GeneLoc Exon Structure for
STARD13
ECgene alternative splicing isoforms for
STARD13

Expression for STARD13 Gene

mRNA expression in normal human tissues for STARD13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STARD13 Gene

SOURCE GeneReport for Unigene cluster for STARD13 Gene Hs.507704

mRNA Expression by UniProt/SwissProt for STARD13 Gene

Q9Y3M8-STA13_HUMAN
Tissue specificity: Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
genes like me logo Genes that share expressions with STARD13: view

No data available for mRNA differential expression in normal tissues for STARD13 Gene

Orthologs for STARD13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD13 35
  • 99.46 (n)
  • 99.53 (a)
STARD13 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STARD13 35
  • 86.29 (n)
  • 89.36 (a)
STARD13 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STARD13 35
  • 87.59 (n)
  • 90.29 (a)
STARD13 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stard13 35
  • 85.88 (n)
  • 89.66 (a)
Stard13 16
Stard13 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STARD13 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD13 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stard13 35
  • 85 (n)
  • 88.03 (a)
chicken
(Gallus gallus)
Aves STARD13 35
  • 75.41 (n)
  • 79.07 (a)
STARD13 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD13 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard13 35
  • 69.32 (n)
  • 71.54 (a)
Str.6797 35
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-23e4.3 36
  • 41 (a)
ManyToMany
stard13a 35
  • 66.35 (n)
  • 68.54 (a)
stard13a 36
  • 65 (a)
ManyToMany
stard13b 36
  • 49 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for STARD13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD13 Gene

ENSEMBL:
Gene Tree for STARD13 (if available)
TreeFam:
Gene Tree for STARD13 (if available)

Paralogs for STARD13 Gene

Selected SIMAP similar genes for STARD13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STARD13: view

Variants for STARD13 Gene

Sequence variations from dbSNP and Humsavar for STARD13 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs471400 -- 33,460,207(-) cccgg(C/G)cCAAT intron-variant
rs475303 -- 33,105,907(-) TGACA(A/G)CATGA intron-variant
rs477259 -- 33,131,149(+) TTGCA(C/T)AGCCT intron-variant
rs480207 -- 33,377,762(+) AAGGT(A/G)TGTGA intron-variant
rs484881 -- 33,378,271(-) TGGAC(A/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD13 Gene

Variant ID Type Subtype PubMed ID
nsv526667 CNV Loss 19592680
nsv819300 CNV Gain 19587683
nsv63989 CNV Loss 16902084
esv1518161 CNV Insertion 17803354
esv2609362 CNV Deletion 19546169
esv2410834 CNV Deletion 18987734
esv2747244 CNV Deletion 23290073
esv2747245 CNV Deletion 23290073
nsv991 CNV Loss 18451855
nsv899971 CNV Loss 21882294
nsv519343 CNV Loss 19592680
nsv992 CNV Insertion 18451855
nsv899972 CNV Loss 21882294
esv259516 OTHER Complex 20981092
nsv510328 CNV Loss 20534489
nsv993 CNV Loss 18451855
esv2661972 CNV Deletion 23128226
esv1005893 CNV Deletion 20482838
nsv899973 CNV Loss 21882294
nsv832578 CNV Gain 17160897
esv275565 CNV Loss 21479260
nsv994 CNV Loss 18451855
nsv9065 CNV Gain 18304495
nsv899974 CNV Loss 21882294
dgv345e199 CNV Deletion 23128226
esv2747246 CNV Deletion 23290073
nsv514693 CNV Loss 21397061
esv27387 CNV Loss 19812545
esv2421478 CNV Deletion 20811451
nsv437163 CNV Loss 16327808
dgv320n67 CNV Loss 20364138
nsv436167 CNV Deletion 17901297
nsv820553 CNV Deletion 20802225
esv2747247 CNV Deletion 23290073
dgv346e199 CNV Deletion 23128226
esv21834 CNV Gain 19812545
esv32975 CNV Loss 17666407
nsv510578 CNV Loss 20534489
nsv438249 CNV Loss 16468122
esv2661694 CNV Deletion 23128226
esv29481 CNV Loss 19812545

Relevant External Links for STARD13 Gene

HapMap Linkage Disequilibrium report
STARD13
Human Gene Mutation Database (HGMD)
STARD13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD13 Gene

Disorders for STARD13 Gene

(2) Novoseek inferred disease relationships for STARD13 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 53.6 4
tumors 14.2 8

Relevant External Links for STARD13

Genetic Association Database (GAD)
STARD13
Human Genome Epidemiology (HuGE) Navigator
STARD13
genes like me logo Genes that share disorders with STARD13: view

No data available for UniProtKB/Swiss-Prot for STARD13 Gene

Publications for STARD13 Gene

  1. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. (PMID: 16217026) Leung T.H.-Y. … Ng I.O. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  2. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. (PMID: 12531887) Ching Y.-P. … Ng I.O. (J. Biol. Chem. 2003) 3 4 23
  3. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PMID: 14697242) Nagaraja G.M. … Kandpal R.P. (Biochem. Biophys. Res. Commun. 2004) 3 4
  4. Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. (PMID: 17016643) Ullmannova V. … Popescu N.C. (Int. J. Oncol. 2006) 3 23
  5. Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma. (PMID: 18651974) Xiaorong L. … Kaiyan Y. (BMC Cancer 2008) 3 23

Products for STARD13 Gene

Sources for STARD13 Gene

Back to Top

Content