Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STARD13 Gene

protein-coding   GIFtS: 59
GCID: GC13M033677

StAR-Related Lipid Transfer (START) Domain Containing 13

(Previous names: START domain containing 13, long intergenic non-protein...)
(Previous symbol: LINC00464)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
StAR-Related Lipid Transfer (START) Domain Containing 131 2     START Domain Containing 131
DLC22 3 5     ARHGAP372
LINC004641 2     Rho GTPase Activating Protein On Chromosome 13q122
Long Intergenic Non-Protein Coding RNA 4641 2     StAR-Related Lipid Transfer Protein 132
Deleted In Liver Cancer 2 Protein2 3     StARD133
46H23.22 3     Rho GTPase-Activating Protein3
DLC-22 3     START Domain-Containing Protein 133
GT6502 3     

External Ids:    HGNC: 191641   Entrez Gene: 906272   Ensembl: ENSG000001331217   OMIM: 6098665   UniProtKB: Q9Y3M83   

Export aliases for STARD13 gene to outside databases

Previous GC identifers: GC13M031663 GC13M027663 GC13M032613 GC13M031475 GC13M032575 GC13M014489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for STARD13 Gene:
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein
interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal
STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell
proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a
region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Aug 2011)

GeneCards Summary for STARD13 Gene:
STARD13 (StAR-related lipid transfer (START) domain containing 13) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP36.

UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8
Function: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal
reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells

Gene Wiki entry for STARD13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STARD13 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): STARD13 promoter sequence
   Search Chromatin IP Primers for STARD13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STARD13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.1   Ensembl cytogenetic band:  13q13.1   HGNC cytogenetic band: 13q13.1

STARD13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STARD13 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M033677:  view genomic region     (about GC identifiers)

Start:
33,677,272 bp from pter      End:
33,924,767 bp from pter
Size:
247,496 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8 (See protein sequence)
Recommended Name: StAR-related lipid transfer protein 13  
Size: 1113 amino acids; 124967 Da
Subunit: Homodimer. Interacts with TAX1BP1
3 PDB 3D structures from and Proteopedia for STARD13:
2H80 (3D)        2JW2 (3D)        2PSO (3D)    
Secondary accessions: A2A309 A2A310 Q5HYH1 Q5TAE3 Q6UN61 Q86TP6 Q86WQ3 Q86XT1
Alternative splicing: 5 isoforms:  Q9Y3M8-1   Q9Y3M8-2   Q9Y3M8-3   Q9Y3M8-4   Q9Y3M8-5   

Explore the universe of human proteins at neXtProt for STARD13: NX_Q9Y3M8

Explore proteomics data for STARD13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See STARD13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001230395.1  NP_001230403.1  NP_001230405.1  NP_443083.1  NP_821074.1  NP_821075.1  

    ENSEMBL proteins: 
     ENSP00000338785   ENSP00000255486   ENSP00000382300   ENSP00000456233   ENSP00000457840  
    Reactome Protein details: Q9Y3M8

    STARD13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for STARD13
    OriGene Protein Over-expression Lysate for STARD13
    OriGene MassSpec for STARD13
    OriGene Custom Protein Services for STARD13
    GenScript Custom Purified and Recombinant Proteins Services for STARD13
    Novus Biologicals STARD13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STARD13

     
    Search eBioscience for Proteins for STARD13 

    STARD13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for STARD13
    OriGene Custom Antibody Services for STARD13
    Novus Biologicals STARD13 Antibody
    Abcam antibodies for STARD13
    Cloud-Clone Corp. Antibodies for STARD13
    Search ThermoFisher Antibodies for STARD13
    LSBio Antibodies in human, mouse, rat for STARD13

    STARD13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STARD13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STARD13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STARD13
    Cloud-Clone Corp. CLIAs for STARD13
    Search eBioscience for ELISAs for STARD13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    StARD: StAR-related lipid transfer (START) domain containing
    ARHGAP: Rho GTPase activating proteins

    Selected InterPro protein domains (see all 6):
     IPR013761 SAM/pointed
     IPR011510 SAM_2
     IPR023393 START-like_dom
     IPR008936 Rho_GTPase_activation_prot
     IPR002913 START_lipid-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y3M8

    ProtoNet protein and cluster: Q9Y3M8

    3 Blocks protein domains:
    IPB000198 RhoGAP domain
    IPB002913 Lipid-binding START
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain
    Similarity: Contains 1 START domain


    Find genes that share domains with STARD13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STA13_HUMAN, Q9Y3M8
    Function: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal
    reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI14697242
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with STARD13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STARD13:
     High actin ratio cells 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Stard13):
     adipose tissue  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with STARD13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for STARD13: Stard13tm1.2Fms Stard13tm1Ioln

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STARD13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STARD13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STARD13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STARD13

    miRNA
    Products:
        
    miRTarBase miRNAs that target STARD13:
    hsa-mir-122-5p (MIRT023222)

    Block miRNA regulation of human, mouse, rat STARD13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STARD13 (see all 88):
    hsa-miR-3938 hsa-miR-15a hsa-miR-877* hsa-miR-298 hsa-miR-200b hsa-miR-92b hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidSTARD13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STARD13
    Predesigned siRNA for gene silencing in human, mouse, rat STARD13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STARD13

    Clone
    Products:
         
    OriGene clones in human, mouse for STARD13 (see all 17)
    OriGene ORF clones in mouse, rat for STARD13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): STARD13 (NM_052851)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STARD13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STARD13
    Browse ESI BIO Cell Lines and PureStem Progenitors for STARD13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STA13_HUMAN, Q9Y3M8: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane;
    Peripheral membrane protein; Cytoplasmic side. Lipid droplet
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    nucleus3
    cytoskeleton2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005811lipid particle IEA--
    GO:0005829cytosol TAS--
    GO:0031966mitochondrial membrane IEA--

    Find genes that share ontologies with STARD13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STARD13 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with STARD13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for STARD13
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STARD13
    Interactions:

        GeneGlobe Interaction Network for STARD13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for STARD13 (Q9Y3M81, 2, 3 ENSP000003387854) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAX1BP1Q86VP11, 3, ENSP000003796124EBI-465487,EBI-529518 I2D: score=5 STRING: ENSP00000379612
    SMAD1Q157972, 3MINT-62010 I2D: score=3 
    EPB41L1Q9H4G03, ENSP000003371684I2D: score=5 STRING: ENSP00000337168
    CNTN2Q022463, ENSP000003306334I2D: score=1 STRING: ENSP00000330633
    BAI2O602413, ENSP000003627624I2D: score=5 STRING: ENSP00000362762
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with STARD13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STARD13 (STA13)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STARD13 gene (7 alternative transcripts): 
    NM_001243466.1  NM_001243474.1  NM_001243476.1  NM_052851.2  NM_178006.3  NM_178007.2  NM_178008.1  

    Unigene Cluster for STARD13:

    StAR-related lipid transfer (START) domain containing 13
    Hs.507704  [show with all ESTs]
    Unigene Representative Sequence: NM_001243476
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336934(uc001uuw.3) ENST00000255486(uc001uuu.3 uc021rhz.1)
    ENST00000399365(uc001uuv.3 uc001uux.3 uc021ria.1) ENST00000491333
    ENST00000567873(uc010abh.1) ENST00000487412 ENST00000498019 ENST00000344312
    ENST00000439831
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STARD13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STARD13 (see all 88):
    hsa-miR-3938 hsa-miR-15a hsa-miR-877* hsa-miR-298 hsa-miR-200b hsa-miR-92b hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidSTARD13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STARD13
    Predesigned siRNA for gene silencing in human, mouse, rat STARD13
    Clone
    Products:
         
    OriGene clones in human, mouse for STARD13 (see all 17)
    OriGene ORF clones in mouse, rat for STARD13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): STARD13 (NM_052851)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STARD13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD13
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STARD13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STARD13
      QuantiTect SYBR Green Assays in human, mouse, rat STARD13
      QuantiFast Probe-based Assays in human, mouse, rat STARD13

    Additional mRNA sequence: 

    AK091804.1 AK094704.1 AK095114.1 AK308430.1 AK308453.1 AK312888.1 AL049801.1 AY082589.1 
    AY082590.1 AY082591.1 AY082592.1 AY366448.1 BC046563.1 BX641149.1 BX647695.1 

    14 DOTS entries:

    DT.102831428  DT.100766864  DT.315494  DT.100714251  DT.100766865  DT.101981886  DT.100766860  DT.101981884 
    DT.40131005  DT.40251259  DT.207700  DT.97812694  DT.92004352  DT.92021481 

    Selected AceView cDNA sequences (see all 164):

    BE349319 AW295469 AW014281 H53015 AI381181 H49574 CA389255 AK095114 
    AW628581 NM_052851 BX118018 CR597966 BE293955 AW474925 BM713913 BQ691857 
    AA568180 AI082579 BU180161 BI906055 BF059253 CA445183 AI627680 AA128066 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for STARD13 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a ·
    SP1:                          -     -     -     -     -                 -     -           -                                         -     -                     
    SP2:                                                                    -     -           -                                         -     -                     
    SP3:                          -     -     -     -     -                 -     -           -                                         -     -                     
    SP4:                                                  -                 -     -           -                                         -     -                     
    SP5:                                                                    -     -           -                             -                                       

    ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for STARD13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STARD13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATTTTTA
    STARD13 Expression
    About this image


    STARD13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    STARD13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STARD13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507704

    UniProtKB/Swiss-Prot: STA13_HUMAN, Q9Y3M8
    Tissue specificity: Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast
    cancer cell lines

        Custom PCR Arrays for STARD13
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STARD13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STARD13
    QuantiTect SYBR Green Assays in human, mouse, rat STARD13
    QuantiFast Probe-based Assays in human, mouse, rat STARD13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for STARD13 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stard131 , 5 StAR-related lipid transfer (START) domain containing more1, 5 85.88(n)1
    89.66(a)1
      5 (89.82 cM)5
    2433621  NM_146258.21  NP_666370.31 
     1510376285 
    chicken
    (Gallus gallus)
    Aves STARD131 StAR-related lipid transfer (START) domain containing more 75.41(n)
    79.07(a)
      418908  XM_004938758.1  XP_004938815.1 
    lizard
    (Anolis carolinensis)
    Reptilia STARD136
    StAR-related lipid transfer (START) domain contain...
    76(a)
    1 ↔ 1
    GL344040.1(22905-63940)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ631133.12   -- 75.14(n)    BJ631133.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI562852.12   -- 78.81(n)    BI562852.1 


    ENSEMBL Gene Tree for STARD13 (if available)
    TreeFam Gene Tree for STARD13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STARD13 gene
    ARHGAP362  ARHGAP62  ARHGAP402  ARHGAP182  DLC12  ARHGAP11A2  ARHGAP282  ARHGAP11B2  
    STARD82  
    3 SIMAP similar genes for STARD13 using alignment to 4 protein entries:     STA13_HUMAN (see all proteins):
    DKFZp686I04252    DLC1    STARD8

    Find genes that share paralogs with STARD13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STARD13 (see all 11920)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996746941,2
    C--14507522(+) AAAAA-/GAAAAA 6 -- int10--------
    rs113118131,2
    C--14513789(+) AGAGC-/AAGCTG 6 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs1443601701,2
    C--14517375(+) ATATG-/ATTTTTT 6 -- int10--------
    rs347094291,2
    C--14517376(+) TATGA-/TTTTTT 6 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs752244481,2
    F--14518236(-) GGTCCC/TTCCTA 6 -- int11Minor allele frequency- T:0.33NA 6
    rs580440721,2
    C,F--14519592(+) AAAAA-/A/AA  
            
    TTTAT
    6 -- int12NA CSA 4
    rs357310081,2
    C--14519593(+) AAAGC-/AAAAAA 6 -- int10--------
    rs105778931,2
    C--14520158(+) AAGAA-/GAATTGTC 6 -- int10--------
    rs1419819891,2
    C--14522104(+) TCAAA-/GTGCTT 6 -- int10--------
    rs718757971,2
    C--14524352(+) TTGGC-/T/T   
       T
    /TTT
    TTTTT
    12 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for STARD13 (33677272 - 33924767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STARD13 (see all 41):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2609362CNV Deletion19546169
    esv2661694CNV Deletion23128226
    esv1005893CNV Deletion20482838
    nsv436167CNV Deletion17901297
    esv2410834CNV Deletion18987734
    esv2747244CNV Deletion23290073
    esv2747247CNV Deletion23290073
    esv2747245CNV Deletion23290073
    nsv820553CNV Deletion20802225
    dgv346e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STARD13
    DNA2.0 Custom Variant and Variant Library Synthesis for STARD13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609866    OMIM disorders: --


    Find genes that share disorders with STARD13           About GenesLikeMe

    2 Novoseek inferred disease relationships for STARD13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 53.6 4 18651974 (3), 17016643 (1)
    tumors 14.2 8 17016643 (3), 12531887 (2), 16217026 (2), 18651974 (1)

    Genetic Association Database (GAD): STARD13
    Human Genome Epidemiology (HuGE) Navigator: STARD13 (6 documents)

    Export disorders for STARD13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STARD13 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with STARD13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. (PubMed id 12531887)1, 2, 9 Ching Y.-P.... Ng I.O. (J. Biol. Chem. 2003)
    2. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. (PubMed id 16217026)1, 2, 9 Leung T.H.-Y.... Ng I.O. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    3. Genome-wide association study of intracranial aneurysm identifies three new risk loci. (PubMed id 20364137)1, 4 Yasuno K....GA1nel M. (Nat. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    7. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)1, 2 Nagaraja G.M. and Kandpal R.P. (Biochem. Biophys. Res. Commun. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 3 Couch F.J.... Simard J. (Genomics 1996)
    10. Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma. (PubMed id 18651974)1, 9 Xiaorong L....Kaiyan Y. (BMC Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 90627 HGNC: 19164 AceView: STARD13 Ensembl:ENSG00000133121 euGenes: HUgn90627
    ECgene: STARD13 H-InvDB: STARD13

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STARD13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for STARD13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STARD13 gene:
    Search GeneIP for patents involving STARD13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for STARD13   OriGene RNAi products in human, mouse, rat for STARD13  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for STARD13  
     OriGene MassSpec something-or-other for STARD13   OriGene clones in human, mouse for STARD13  
     OriGene qSTAR qPCR primer pairs in human, mouse for STARD13   OriGene Purified Protein for STARD13  
     OriGene ORF clones in mouse, rat for STARD13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STARD13   OriGene Custom Protein Services for STARD13  

     
     
     Block miRNA regulation of human, mouse, rat STARD13 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STARD13
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STARD13 Predesigned siRNA for gene silencing in human, mouse, rat STARD13
     QuantiFast Probe-based Assays in human, mouse, rat STARD13 QuantiTect SYBR Green Assays in human, mouse, rat STARD13
     Custom PCR Arrays for STARD13 Search Chromatin IP Primers for STARD13
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STARD13  GeneGlobe Interaction Network for STARD13
     Regulatory tfbs in STARD13 promoter
     GenScript Custom Purified and Recombinant Proteins Services for STARD13 GenScript cDNA clones with any tag delivered in your preferred vector for STARD13
     GenScript Custom Assay Services for STARD13 GenScript Custom overexpressing Cell Line Services for STARD13
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STARD13 (STA13)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STARD13 antibodies
     STARD13 lysates
     Antibodies for STARD13
     See all of Abcam's Antibodies, Kits and Proteins for STARD13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for STARD13
     Antibodies for STARD13
     ELISAs for STARD13
     CLIAs for STARD13



     Browse ESI BIO Cell Lines and PureStem Progenitors for STARD13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STARD13
     SwitchGear 3'UTR luciferase reporter plasmids for STARD13
     SwitchGear Promoter luciferase reporter plasmids for STARD13
     Search ThermoFisher Antibodies for STARD13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STARD13
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STARD13
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STARD13
     LSBio Antibodies in human, mouse, rat for STARD13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for STARD13
      Search eBioscience for proteins for STARD13
      Search eBioscience for elisas for STARD13
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STARD13 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4