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Aliases for STARD10 Gene

Aliases for STARD10 Gene

  • StAR Related Lipid Transfer Domain Containing 10 2 3 5
  • Serologically Defined Colon Cancer Antigen 28 2 3 4
  • StAR-Related Lipid Transfer Protein 10 3 4
  • START Domain-Containing Protein 10 3 4
  • START Domain Containing 10 2 3
  • Antigen NY-CO-28 3 4
  • SDCCAG28 3 4
  • PCTP-L 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 10 3
  • PCTP-Like Protein 3
  • NY-CO-28 3
  • StARD10 4
  • CGI-52 3
  • PCTP2 3

External Ids for STARD10 Gene

Previous HGNC Symbols for STARD10 Gene

  • SDCCAG28

Previous GeneCards Identifiers for STARD10 Gene

  • GC11M074005
  • GC11M072192
  • GC11M072143
  • GC11M072465
  • GC11M068761

Summaries for STARD10 Gene

GeneCards Summary for STARD10 Gene

STARD10 (StAR Related Lipid Transfer Domain Containing 10) is a Protein Coding gene. Among its related pathways are Synthesis of PC and Glycerophospholipid biosynthesis. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for STARD10 Gene

  • May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Gene Wiki entry for STARD10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD10 Gene

Genomics for STARD10 Gene

Regulatory Elements for STARD10 Gene

Enhancers for STARD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G072775 2 FANTOM5 Ensembl ENCODE dbSUPER 29.7 +11.1 11095 15.3 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 STARD10 ARAP1 MIR4692 ENSG00000202522
GH11G072811 1.4 ENCODE dbSUPER 40.2 -20.0 -20043 5.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A STARD10 LOC100133315 ENSG00000248671 ARAP1 RNU6-672P ARAP1-AS1 ATG16L2
GH11G072792 1.4 ENCODE dbSUPER 24.5 +0.1 107 3.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 STARD10 ARAP1 LOC105369380
GH11G072771 1.4 Ensembl ENCODE dbSUPER 24 +20.8 20758 3.4 HDAC1 FOXA2 SIN3A ZBTB40 YY1 EGR1 SCRT2 FOS EGR2 CEBPB STARD10 ARAP1 ATG16L2 ENSG00000202522 MIR4692
GH11G072826 1.2 Ensembl ENCODE dbSUPER 27.9 -33.7 -33728 3.6 HDGF TFAP4 MAX RARA FOXK2 POLR2A NR2F6 NR2F1 BHLHE40 NR2F2 STARD10 RNU6-672P ARAP1 RPS12P20 ARAP1-AS2 ATG16L2 GC11M072870
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STARD10 on UCSC Golden Path with GeneCards custom track

Promoters for STARD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041772 168 801 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B
ENSR00000041772 -295 801 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for STARD10 Gene

Chromosome:
11
Start:
72,754,729 bp from pter
End:
72,794,168 bp from pter
Size:
39,440 bases
Orientation:
Minus strand

Genomic View for STARD10 Gene

Genes around STARD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD10 Gene

Proteins for STARD10 Gene

  • Protein details for STARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y365-PCTL_HUMAN
    Recommended name:
    PCTP-like protein
    Protein Accession:
    Q9Y365
    Secondary Accessions:
    • O60532

    Protein attributes for STARD10 Gene

    Size:
    291 amino acids
    Molecular mass:
    33049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC18045.1; Type=Miscellaneous discrepancy; Note=Various sequencing problems as well as a translation in a wrong frame.; Evidence={ECO:0000305}; Sequence=AAD34047.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for STARD10 Gene

Post-translational modifications for STARD10 Gene

  • Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD10 Gene

Domains & Families for STARD10 Gene

Gene Families for STARD10 Gene

Protein Domains for STARD10 Gene

Suggested Antigen Peptide Sequences for STARD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STARD10: view

No data available for UniProtKB/Swiss-Prot for STARD10 Gene

Function for STARD10 Gene

Molecular function for STARD10 Gene

UniProtKB/Swiss-Prot Function:
May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Gene Ontology (GO) - Molecular Function for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD10: view
genes like me logo Genes that share phenotypes with STARD10: view

Animal Models for STARD10 Gene

MGI Knock Outs for STARD10:

Animal Model Products

CRISPR Products

miRNA for STARD10 Gene

miRTarBase miRNAs that target STARD10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD10 Gene

Localization for STARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD10 Gene

Cell projection, cilium, flagellum. Cytoplasm. Membrane. Note=In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD10 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005902 microvillus IBA --
GO:0016020 membrane IBA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STARD10: view

Pathways & Interactions for STARD10 Gene

genes like me logo Genes that share pathways with STARD10: view

Pathways by source for STARD10 Gene

Interacting Proteins for STARD10 Gene

SIGNOR curated interactions for STARD10 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0032782 bile acid secretion IEA --
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with STARD10: view

Drugs & Compounds for STARD10 Gene

No Compound Related Data Available

Transcripts for STARD10 Gene

Unigene Clusters for STARD10 Gene

StAR-related lipid transfer (START) domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD10 Gene

No ASD Table

Relevant External Links for STARD10 Gene

GeneLoc Exon Structure for
STARD10
ECgene alternative splicing isoforms for
STARD10

Expression for STARD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STARD10 Gene

This gene is overexpressed in Liver (x9.6).

Protein differential expression in normal tissues from HIPED for STARD10 Gene

This gene is overexpressed in Breast (14.2) and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STARD10 Gene



Protein tissue co-expression partners for STARD10 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD10 Gene:

STARD10

SOURCE GeneReport for Unigene cluster for STARD10 Gene:

Hs.188606

Evidence on tissue expression from TISSUES for STARD10 Gene

  • Liver(4.4)
  • Nervous system(3.9)
  • Intestine(3.4)
  • Gall bladder(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with STARD10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD10 Gene

Orthologs for STARD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD10 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia STARD10 34 35
  • 92.9 (n)
cow
(Bos Taurus)
Mammalia STARD10 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Stard10 34 16 35
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Stard10 34
  • 90.46 (n)
oppossum
(Monodelphis domestica)
Mammalia STARD10 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD10 34 35
  • 71.41 (n)
lizard
(Anolis carolinensis)
Reptilia STARD10 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard10 34
  • 73.28 (n)
Str.11784 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8320 34
zebrafish
(Danio rerio)
Actinopterygii zgc:77147 34
  • 72.28 (n)
STARD10 35
  • 43 (a)
OneToOne
zgc56270 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5576 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008308 34
  • 50.73 (n)
worm
(Caenorhabditis elegans)
Secernentea T28D6.7 34 35
  • 47.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9553 35
  • 40 (a)
OneToOne
Species where no ortholog for STARD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD10 Gene

ENSEMBL:
Gene Tree for STARD10 (if available)
TreeFam:
Gene Tree for STARD10 (if available)

Paralogs for STARD10 Gene

No data available for Paralogs for STARD10 Gene

Variants for STARD10 Gene

Sequence variations from dbSNP and Humsavar for STARD10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024933 -- 72,755,537(+) AACTC(C/T)CGACC intron-variant
rs1000045807 -- 72,762,753(+) CAGGA(G/T)GTAGG intron-variant
rs1000186800 -- 72,755,757(+) GCCTG(A/T)GAGGG intron-variant
rs1000269491 -- 72,761,395(+) TGAAC(A/G)TGATC intron-variant
rs1000345065 -- 72,775,320(+) TACAG(C/T)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STARD10 Gene

Variant ID Type Subtype PubMed ID
esv2744771 CNV deletion 23290073
nsv1070051 CNV deletion 25765185
nsv1118220 CNV deletion 24896259
nsv825992 CNV gain 20364138
nsv832207 CNV loss 17160897

Variation tolerance for STARD10 Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STARD10 Gene

Human Gene Mutation Database (HGMD)
STARD10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD10 Gene

Disorders for STARD10 Gene

Relevant External Links for STARD10

Genetic Association Database (GAD)
STARD10
Human Genome Epidemiology (HuGE) Navigator
STARD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STARD10

No disorders were found for STARD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD10 Gene

Publications for STARD10 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. (PMID: 17561512) Olayioye M.A. … Pomorski T. (J. Biol. Chem. 2007) 3 4 64
  4. StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein. (PMID: 15911624) Olayioye M.A. … Pomorski T. (J. Biol. Chem. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for STARD10 Gene

Sources for STARD10 Gene

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