STAP2 Gene
protein-coding GIFtS: 52
GCID: GC19M004324
|
|
signal transducing adaptor family member 2
| |
Aliases
for STAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Signal Transducing Adaptor Family Member 21 2 | | BRK Substrate2 3 | | BKS1 2 3 | | Brk Kinase Substrate2 | | STAP-21 3 | | Signal-Transducing Adaptor Protein 22 | | Breast Tumor Kinase Substrate2 3 | | Signal-Transducing Adaptor Protein-22 |
Export aliases for STAP2 gene to outside databasesPrevious GC identifers: GC19M004264 GC19M004275 GC19M004086 |
Summaries
for STAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STAP2:
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded proteinpossesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate theinteractions linking proteins involved in signal transduction pathways. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: STAP2_HUMAN, Q9UGK3Function: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemicinflammation and may modulate STAT3 activity
Gene Wiki entry for STAP2
|
Genomic Views
for STAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STAP2 gene promoter:
USF2 STAT3 STAT5A NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for STAP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3STAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M004324: view genomic region
(about GC identifiers)
Start:
|
4,324,040 bp from pter |
End:
|
4,338,847 bp from pter |
Size:
|
14,808 bases |
Orientation:
|
minus strand |
|
Proteins
for STAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAP2_HUMAN, Q9UGK3 (See
protein sequence)Recommended Name: Signal-transducing adaptor protein 2 Size: 403 amino acids; 44894 Da
Subunit: Interacts with PTK6 and CSF1R
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for STAP2:2EL8 (3D)
Secondary accessions: A6NKK3 Q9NXI2Alternative splicing: 2 isoforms: Q9UGK3-1 Q9UGK3-2 (Alu insert from position 358 to 403)Explore the universe of human proteins at neXtProt for STAP2: NX_Q9UGK3
Post-translational modifications:
Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGK3
STAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001013863.1 NP_060190.2
ENSEMBL proteins: ENSP00000317912 ENSP00000411838
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
STAP2 for ontologies About GeneDecksing
STAP2 Antibody Products:
Assay Products for STAP2: |
Protein
Domains /
Families
for STAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STAP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UGK3ProtoNet protein and cluster: Q9UGK3 2 Blocks protein families: IPB000980 SH2 domain signature IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: STAP2_HUMAN, Q9UGK3Similarity: Contains 1 PH domainSimilarity: Contains 1 SH2 domain |
Function
for STAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STAP2_HUMAN, Q9UGK3Function: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemicinflammation and may modulate STAT3 activity
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAP2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
STAP2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Stap2tm1Ayos for STAP2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Stap2):
STAP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for STAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/14 Interacting proteins for STAP2 (Q9UGK31, 2, 3 ENSP000003179124) via UniProtKB, MINT, STRING, and/or I2D (see all 14)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| STAT5A | P422292, 3, ENSP000003412084 | MINT-58264 MINT-58265 MINT-58273 MINT-58274 MINT-58254 MINT-58266 MINT-58261 MINT-58267 MINT-58258 MINT-58272 MINT-58257 I2D:
score=2 STRING: ENSP00000341208 | | STAT5B | P516922, 3, ENSP000002933284 | MINT-58271 MINT-58270 MINT-58259 MINT-58256 MINT-58275 MINT-58255 MINT-58269 MINT-58268 MINT-58276 MINT-58260 I2D:
score=2 STRING: ENSP00000293328 | | MYD88 | Q998361, 3, ENSP000003796254 | EBI-1553984,EBI-447677 I2D:
score=3 STRING: ENSP00000379625 | | IKBKB | O149201, 3, ENSP000003391514 | EBI-1553984,EBI-81266 I2D:
score=3 STRING: ENSP00000339151 | | CHUK | O151113, ENSP000003594244 | I2D:
score=2 STRING: ENSP00000359424 |
About this table
|
Drugs & Compounds
for STAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STAP2
Search CenterWatch for drugs/clinical trials and news about STAP2
|
Transcripts
for STAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STAP2 gene (2 alternative transcripts): NM_001013841.1 NM_017720.2 Unigene Cluster for STAP2: Signal transducing adaptor family member 2 Hs.194385 [show with all ESTs]Unigene Representative Sequence: AK1257742 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314714(uc002mac.3 uc021unc.1 uc002mad.3) ENST00000424810(uc002mab.3 uc021unb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): STAP2 (NM_001013841) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAP2 |
Additional cDNA sequence: AJ245719.1 AK000241.1 AK125774.1 BC000795.1 8 DOTS entries: DT.210774 DT.100812875 DT.95169797 DT.91663291 DT.100803756 DT.40111859 DT.95169798 DT.100812877 24/123 AceView cDNA sequences (see all 123): BM980638 BC000795 BM666369 CB850669 BG752660 BF515055 BM552002 BG740811 AI190504 CB161171 AK125774 AJ245719 BX107197 CB116885 BU956623 AI832281 BM695192 BM820456 CR596893 AW152661 BI765700 BI859367 BG821254 BE222663
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for STAP2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STAP2
|
Expression
for STAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCAGCGGC
About this image
See STAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAP2
SOURCE GeneReport for Unigene cluster: Hs.194385
UniProtKB/Swiss-Prot: STAP2_HUMAN, Q9UGK3Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for STAP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAP2 |
Orthologs
for STAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for STAP2 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for STAP2 (if available)
TreeFam Gene Tree for STAP2 (if available) |
Paralogs
for STAP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STAP2 gene
- STAP12
1 SIMAP similar gene for STAP2 using alignment to 5 protein entries: STAP2_HUMAN (see all proteins):STAP1
STAP2 for paralogs About GeneDecksing
|
Genomic Variants
for STAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STAP2 (4324040 - 4338847 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for STAP2
1 CNV: 5075
2 Indels: 41443 60270 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAP2 |
|
Disorders
/ Diseases
for STAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STAP2 for disorders About GeneDecksing
OMIM gene information: 607881
OMIM disorders: --
3  diseases for STAP2: About MalaCardsbreast cancer leukemia sepsis
1 disease from the University of Copenhagen DISEASES database for STAP2:Diabetes mellitus Human Genome Epidemiology (HuGE) Navigator: STAP2 (1 document)
Export disorders for STAP2 gene to outside databases
|
Publications
for STAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STAP2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with STAP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel adaptor-like protein which is a substrate for the non- receptor tyrosine kinase, BRK. (PubMed id 10980601)1, 2, 3, 9 Mitchell P.J.... Crompton M.R. (2000)
- STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. (PubMed id 19393627)1, 2, 9 Ikeda O....Matsuda T. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. (PubMed id 12540842)1, 2 Minoguchi M.... Yoshimura A. (2003)
- Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (2001)
- The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. (PubMed id 19401194)1, 9 Sekine Y....Matsuda T. (2009)
- Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase. (PubMed id 17675501)1, 9 Sekine Y....Matsuda T. (2007)
- Signal-transducing adaptor protein-2 regulates stroma l cell-derived factor-1 alpha-induced chemotaxis in T cells. (PubMed id 19933863)1, 9 Sekine Y....Matsuda T. (2009)
- Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. (PubMed id 16365431)1, 9 Sekine Y....Matsuda T. (2006)
|
External Searches for STAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STAP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STAP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STAP2 gene:
Search GeneIP for patents involving STAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAP2 |
| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAP2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAP2 |
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