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Aliases for STAP2 Gene

Aliases for STAP2 Gene

  • Signal Transducing Adaptor Family Member 2 2 3 5
  • Breast Tumor Kinase Substrate 3 4
  • BRK Substrate 3 4
  • BKS 3 4
  • Signal-Transducing Adaptor Protein 2 3
  • Brk Kinase Substrate 3
  • STAP-2 4

External Ids for STAP2 Gene

Previous GeneCards Identifiers for STAP2 Gene

  • GC19M004264
  • GC19M004275
  • GC19M004086

Summaries for STAP2 Gene

Entrez Gene Summary for STAP2 Gene

  • This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAP2 Gene

STAP2 (Signal Transducing Adaptor Family Member 2) is a Protein Coding gene. Among its related pathways are Signaling by PTK6 and Signaling by GPCR. An important paralog of this gene is STAP1.

UniProtKB/Swiss-Prot for STAP2 Gene

  • Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.

Gene Wiki entry for STAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAP2 Gene

Genomics for STAP2 Gene

Regulatory Elements for STAP2 Gene

Enhancers for STAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G004340 1.2 ENCODE 33.8 +0.3 346 3.5 HDGF PKNOX1 MLX WRNIP1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF766 STAP2 SH3GL1 DAPK3 ENSG00000267255 FSD1 TMIGD2 SHD CHAF1A TBXA2R ENSG00000269425
GH19G004337 1 ENCODE 34.8 +4.1 4068 2.1 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B GATA2 MXD4 STAP2 ENSG00000269425 FSD1
GH19G004326 1 ENCODE 13.5 +14.6 14568 2.9 HDGF ATF1 PKNOX1 CREB3L1 AGO1 SIN3A TCF12 ZNF143 FOS KLF13 STAP2 ENSG00000269425 FSD1
GH19G004300 1.1 Ensembl ENCODE 12 +39.9 39913 4.5 RB1 CREB3L1 ZNF493 ZNF76 ETS1 ZNF335 ZNF121 ZNF143 KDM4B CREM ENSG00000267205 STAP2 FSD1 TMIGD2
GH19G004347 0.4 ENCODE 26.1 -4.7 -4695 0.8 FOXM1 ZNF10 STAP2 TMIGD2 FSD1 SHD SH3GL1 CHAF1A EIF1P6 MPND
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STAP2 on UCSC Golden Path with GeneCards custom track

Promoters for STAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106191 -514 1801 HDGF PKNOX1 MLX WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1

Genomic Location for STAP2 Gene

Chromosome:
19
Start:
4,324,043 bp from pter
End:
4,342,786 bp from pter
Size:
18,744 bases
Orientation:
Minus strand

Genomic View for STAP2 Gene

Genes around STAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAP2 Gene

Proteins for STAP2 Gene

  • Protein details for STAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGK3-STAP2_HUMAN
    Recommended name:
    Signal-transducing adaptor protein 2
    Protein Accession:
    Q9UGK3
    Secondary Accessions:
    • A6NKK3
    • Q9NXI2

    Protein attributes for STAP2 Gene

    Size:
    403 amino acids
    Molecular mass:
    44894 Da
    Quaternary structure:
    • Interacts with PTK6 and CSF1R.

    Three dimensional structures from OCA and Proteopedia for STAP2 Gene

    Alternative splice isoforms for STAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAP2 Gene

Post-translational modifications for STAP2 Gene

  • Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STAP2 Gene

Domains & Families for STAP2 Gene

Protein Domains for STAP2 Gene

Suggested Antigen Peptide Sequences for STAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STAP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for STAP2 Gene

Function for STAP2 Gene

Molecular function for STAP2 Gene

UniProtKB/Swiss-Prot Function:
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.

Gene Ontology (GO) - Molecular Function for STAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16365431
genes like me logo Genes that share ontologies with STAP2: view

Phenotypes for STAP2 Gene

genes like me logo Genes that share phenotypes with STAP2: view

Animal Models for STAP2 Gene

MGI Knock Outs for STAP2:

Animal Model Products

CRISPR Products

miRNA for STAP2 Gene

miRTarBase miRNAs that target STAP2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STAP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAP2 Gene

Localization for STAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for STAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with STAP2: view

Pathways & Interactions for STAP2 Gene

genes like me logo Genes that share pathways with STAP2: view

Pathways by source for STAP2 Gene

3 Reactome pathways for STAP2 Gene

SIGNOR curated interactions for STAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein TAS --
genes like me logo Genes that share ontologies with STAP2: view

Drugs & Compounds for STAP2 Gene

No Compound Related Data Available

Transcripts for STAP2 Gene

Unigene Clusters for STAP2 Gene

Signal transducing adaptor family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for STAP2

Alternative Splicing Database (ASD) splice patterns (SP) for STAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for STAP2 Gene

GeneLoc Exon Structure for
STAP2
ECgene alternative splicing isoforms for
STAP2

Expression for STAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAP2 Gene

This gene is overexpressed in Colon - Transverse (x6.5), Esophagus - Mucosa (x5.6), Skin - Sun Exposed (Lower leg) (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for STAP2 Gene

This gene is overexpressed in Breast (49.4), Colon (9.4), and Pancreas (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAP2 Gene



Protein tissue co-expression partners for STAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STAP2 Gene:

STAP2

SOURCE GeneReport for Unigene cluster for STAP2 Gene:

Hs.194385

mRNA Expression by UniProt/SwissProt for STAP2 Gene:

Q9UGK3-STAP2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for STAP2 Gene

  • Intestine(4.4)
  • Liver(2.4)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with STAP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STAP2 Gene

Orthologs for STAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAP2 34 35
  • 80.64 (n)
dog
(Canis familiaris)
Mammalia STAP2 34 35
  • 79.21 (n)
rat
(Rattus norvegicus)
Mammalia Stap2 34
  • 75.18 (n)
mouse
(Mus musculus)
Mammalia Stap2 34 16 35
  • 74.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STAP2 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAP2 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAP2 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stap2 34
  • 50.07 (n)
zebrafish
(Danio rerio)
Actinopterygii stap2a 34 35
  • 55.51 (n)
stap2b 35
  • 31 (a)
OneToMany
Species where no ortholog for STAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAP2 Gene

ENSEMBL:
Gene Tree for STAP2 (if available)
TreeFam:
Gene Tree for STAP2 (if available)

Paralogs for STAP2 Gene

Paralogs for STAP2 Gene

(1) SIMAP similar genes for STAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STAP2: view

Variants for STAP2 Gene

Sequence variations from dbSNP and Humsavar for STAP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000014372 -- 4,340,845(+) TGGCA(G/T)AATTC upstream-variant-2KB
rs1000174572 -- 4,330,647(+) GAAAC(-/AG)GGAAA intron-variant
rs1000275526 -- 4,325,280(+) GGCTT(C/T)AGGAT reference, synonymous-codon
rs1000327813 -- 4,336,512(+) GTTTC(A/G)TCATG intron-variant
rs1000443785 -- 4,336,765(+) AAGTA(G/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAP2 Gene

Variant ID Type Subtype PubMed ID
dgv496e201 CNV deletion 23290073
esv2718005 CNV deletion 23290073
esv2718008 CNV deletion 23290073
esv2718010 CNV deletion 23290073
esv2718011 CNV deletion 23290073
esv3361218 CNV duplication 20981092
esv3643498 CNV loss 21293372
esv3643499 CNV loss 21293372
esv4291 CNV loss 18987735
esv9292 CNV gain 19470904
nsv1071895 CNV deletion 25765185
nsv458328 CNV gain 19166990
nsv578443 CNV gain 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897
nsv833719 CNV loss 17160897

Variation tolerance for STAP2 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAP2 Gene

Disorders for STAP2 Gene

Relevant External Links for STAP2

Genetic Association Database (GAD)
STAP2
Human Genome Epidemiology (HuGE) Navigator
STAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAP2

No disorders were found for STAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAP2 Gene

Publications for STAP2 Gene

  1. A novel adaptor-like protein which is a substrate for the non- receptor tyrosine kinase, BRK. (PMID: 10980601) Mitchell P.J. … Crompton M.R. (Oncogene 2000) 2 3 4 22 64
  2. STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk- mediated STAT3 activation. (PMID: 19393627) Ikeda O. … Matsuda T. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  4. The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. (PMID: 19401194) Sekine Y. … Matsuda T. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  5. Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. (PMID: 19933863) Sekine Y. … Matsuda T. (J. Immunol. 2009) 3 22 64

Products for STAP2 Gene

  • Addgene plasmids for STAP2

Sources for STAP2 Gene

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