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Aliases for STAP2 Gene

Aliases for STAP2 Gene

  • Signal Transducing Adaptor Family Member 2 2 3 5
  • Breast Tumor Kinase Substrate 3 4
  • BRK Substrate 3 4
  • BKS 3 4
  • Signal-Transducing Adaptor Protein-2 3
  • Brk Kinase Substrate 3
  • STAP-2 4

External Ids for STAP2 Gene

Previous GeneCards Identifiers for STAP2 Gene

  • GC19M004264
  • GC19M004275
  • GC19M004086

Summaries for STAP2 Gene

Entrez Gene Summary for STAP2 Gene

  • This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAP2 Gene

STAP2 (Signal Transducing Adaptor Family Member 2) is a Protein Coding gene. Among its related pathways are Signaling by PTK6 and Signaling by GPCR. An important paralog of this gene is STAP1.

UniProtKB/Swiss-Prot for STAP2 Gene

  • Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.

Gene Wiki entry for STAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAP2 Gene

Genomics for STAP2 Gene

Regulatory Elements for STAP2 Gene

Enhancers for STAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STAP2 on UCSC Golden Path with GeneCards custom track

Promoters for STAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for STAP2 Gene

4,324,043 bp from pter
4,342,786 bp from pter
18,744 bases
Minus strand

Genomic View for STAP2 Gene

Genes around STAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAP2 Gene

Proteins for STAP2 Gene

  • Protein details for STAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-transducing adaptor protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NKK3
    • Q9NXI2

    Protein attributes for STAP2 Gene

    403 amino acids
    Molecular mass:
    44894 Da
    Quaternary structure:
    • Interacts with PTK6 and CSF1R.

    Three dimensional structures from OCA and Proteopedia for STAP2 Gene

    Alternative splice isoforms for STAP2 Gene


neXtProt entry for STAP2 Gene

Proteomics data for STAP2 Gene at MOPED

Post-translational modifications for STAP2 Gene

  • Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAP2 Gene

No data available for DME Specific Peptides for STAP2 Gene

Domains & Families for STAP2 Gene

Protein Domains for STAP2 Gene

Suggested Antigen Peptide Sequences for STAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with STAP2: view

No data available for Gene Families for STAP2 Gene

Function for STAP2 Gene

Molecular function for STAP2 Gene

UniProtKB/Swiss-Prot Function:
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.

Phenotypes for STAP2 Gene

genes like me logo Genes that share phenotypes with STAP2: view

Animal Models for STAP2 Gene

MGI Knock Outs for STAP2:

Animal Model Products

CRISPR Products

miRNA for STAP2 Gene

miRTarBase miRNAs that target STAP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAP2 Gene

Localization for STAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAP2 Gene


Subcellular locations from

Jensen Localization Image for STAP2 Gene COMPARTMENTS Subcellular localization image for STAP2 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for STAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with STAP2: view

Pathways & Interactions for STAP2 Gene

genes like me logo Genes that share pathways with STAP2: view

Pathways by source for STAP2 Gene

3 Reactome pathways for STAP2 Gene

SIGNOR curated interactions for STAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STAP2 Gene


Drugs & Compounds for STAP2 Gene

No Compound Related Data Available

Transcripts for STAP2 Gene

Unigene Clusters for STAP2 Gene

Signal transducing adaptor family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: - -

Relevant External Links for STAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STAP2 Gene

mRNA expression in normal human tissues for STAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAP2 Gene

This gene is overexpressed in Colon - Transverse (x6.5), Esophagus - Mucosa (x5.6), Skin - Sun Exposed (Lower leg) (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for STAP2 Gene

This gene is overexpressed in Breast (49.4), Colon (9.4), and Pancreas (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for STAP2 Gene

SOURCE GeneReport for Unigene cluster for STAP2 Gene Hs.194385

mRNA Expression by UniProt/SwissProt for STAP2 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with STAP2: view

Protein tissue co-expression partners for STAP2 Gene

Primer Products

Orthologs for STAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STAP2 35
  • 80.64 (n)
  • 77.45 (a)
STAP2 36
  • 76 (a)
(Canis familiaris)
Mammalia STAP2 35
  • 79.21 (n)
  • 75.25 (a)
STAP2 36
  • 74 (a)
(Mus musculus)
Mammalia Stap2 35
  • 74.86 (n)
  • 69.98 (a)
Stap2 16
Stap2 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Stap2 35
  • 75.18 (n)
  • 70.97 (a)
(Monodelphis domestica)
Mammalia STAP2 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia STAP2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia STAP2 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stap2 35
  • 50.07 (n)
  • 42.17 (a)
(Danio rerio)
Actinopterygii stap2a 35
  • 55.51 (n)
  • 50 (a)
stap2a 36
  • 37 (a)
stap2b 36
  • 31 (a)
Species with no ortholog for STAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAP2 Gene

Gene Tree for STAP2 (if available)
Gene Tree for STAP2 (if available)

Paralogs for STAP2 Gene

Paralogs for STAP2 Gene

(1) SIMAP similar genes for STAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STAP2: view

Variants for STAP2 Gene

Sequence variations from dbSNP and Humsavar for STAP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7247504 - 4,333,714(+) CTGAT(A/C/G/T)CCGGA reference, missense
rs7257674 -- 4,331,624(+) gactc(A/T)gtctc intron-variant
rs7257776 -- 4,331,707(+) gcggg(C/T)ggatc intron-variant
rs7257778 -- 4,331,718(+) acgag(G/T)tcagg intron-variant
rs7258060 -- 4,332,108(+) ATCCA(A/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAP2 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
dgv3675n71 CNV Loss 21882294
nsv910824 CNV Gain 21882294
nsv458328 CNV Gain 19166990
nsv833719 CNV Loss 17160897
esv2718005 CNV Deletion 23290073
dgv537e201 CNV Deletion 23290073
esv2718008 CNV Deletion 23290073
esv2718010 CNV Deletion 23290073
esv2718011 CNV Deletion 23290073
esv4291 CNV Deletion 18987735
esv9292 CNV Gain 19470904

Variation tolerance for STAP2 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STAP2 Gene

Disorders for STAP2 Gene

Relevant External Links for STAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAP2 Gene

Publications for STAP2 Gene

  1. A novel adaptor-like protein which is a substrate for the non- receptor tyrosine kinase, BRK. (PMID: 10980601) Mitchell P.J. … Crompton M.R. (Oncogene 2000) 2 3 4 23 67
  2. STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk- mediated STAT3 activation. (PMID: 19393627) Ikeda O. … Matsuda T. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. (PMID: 19401194) Sekine Y. … Matsuda T. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. (PMID: 19933863) Sekine Y. … Matsuda T. (J. Immunol. 2009) 3 23
  5. STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1. (PMID: 18573890) Ikeda O. … Matsuda T. (Mol. Cell. Biol. 2008) 3 23

Products for STAP2 Gene

Sources for STAP2 Gene