Free for academic non-profit institutions. Other users need a Commercial license

Aliases for STAP2 Gene

Aliases for STAP2 Gene

  • Signal Transducing Adaptor Family Member 2 2 3
  • Breast Tumor Kinase Substrate 3 4
  • BRK Substrate 3 4
  • BKS 3 4
  • Signal-Transducing Adaptor Protein 2 3
  • Signal-Transducing Adaptor Protein-2 3
  • Brk Kinase Substrate 3
  • STAP-2 4

External Ids for STAP2 Gene

Summaries for STAP2 Gene

Entrez Gene Summary for STAP2 Gene

  • This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAP2 Gene

STAP2 (Signal Transducing Adaptor Family Member 2) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is STAP1.

UniProtKB/Swiss-Prot for STAP2 Gene

  • Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.

Gene Wiki entry for STAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAP2 Gene

Genomics for STAP2 Gene

Genomic Location for STAP2 Gene

Start:
4,324,043 bp from pter
End:
4,342,786 bp from pter
Size:
18,744 bases
Orientation:
Minus strand

Genomic View for STAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAP2 Gene

Regulatory Elements for STAP2 Gene

Proteins for STAP2 Gene

  • Protein details for STAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGK3-STAP2_HUMAN
    Recommended name:
    Signal-transducing adaptor protein 2
    Protein Accession:
    Q9UGK3
    Secondary Accessions:
    • A6NKK3
    • Q9NXI2

    Protein attributes for STAP2 Gene

    Size:
    403 amino acids
    Molecular mass:
    44894 Da
    Quaternary structure:
    • Interacts with PTK6 and CSF1R.

    Three dimensional structures from OCA and Proteopedia for STAP2 Gene

    Alternative splice isoforms for STAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAP2 Gene

Proteomics data for STAP2 Gene at MOPED

Post-translational modifications for STAP2 Gene

  • Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAP2 Gene

No data available for DME Specific Peptides for STAP2 Gene

Domains for STAP2 Gene

Protein Domains for STAP2 Gene

UniProtKB/Swiss-Prot:

STAP2_HUMAN
Domain:
  • Contains 1 PH domain.:
    • Q9UGK3
  • Contains 1 SH2 domain.:
    • Q9UGK3
genes like me logo Genes that share domains with STAP2: view

No data available for Gene Families for STAP2 Gene

Function for STAP2 Gene

Molecular function for STAP2 Gene

UniProtKB/Swiss-Prot Function: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.

Gene Ontology (GO) - Molecular Function for STAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16365431
genes like me logo Genes that share ontologies with STAP2: view

Phenotypes for STAP2 Gene

MGI mutant phenotypes for STAP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with STAP2: view

Animal Models for STAP2 Gene

MGI Knock Outs for STAP2:

miRNA for STAP2 Gene

miRTarBase miRNAs that target STAP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STAP2 Gene

Localization for STAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAP2 Gene COMPARTMENTS Subcellular localization image for STAP2 gene
Compartment Confidence
nucleus 4
mitochondrion 2
plasma membrane 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for STAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with STAP2: view

Pathways for STAP2 Gene

SuperPathways for STAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAP2 Gene

None

No data available for Pathways by source for STAP2 Gene

Transcripts for STAP2 Gene

Unigene Clusters for STAP2 Gene

Signal transducing adaptor family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for STAP2 Gene

GeneLoc Exon Structure for
STAP2
ECgene alternative splicing isoforms for
STAP2

Expression for STAP2 Gene

mRNA expression in normal human tissues for STAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAP2 Gene

This gene is overexpressed in Colon - Transverse (6.5), Esophagus - Mucosa (5.6), Skin - Sun Exposed (Lower leg) (4.5), and Skin - Not Sun Exposed (Suprapubic) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for STAP2 Gene

SOURCE GeneReport for Unigene cluster for STAP2 Gene Hs.194385

mRNA Expression by UniProt/SwissProt for STAP2 Gene

Q9UGK3-STAP2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with STAP2: view

Orthologs for STAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAP2 36
  • 80.64 (n)
  • 77.45 (a)
STAP2 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAP2 36
  • 79.21 (n)
  • 75.25 (a)
STAP2 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stap2 36
  • 74.86 (n)
  • 69.98 (a)
Stap2 16
Stap2 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAP2 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAP2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stap2 36
  • 75.18 (n)
  • 70.97 (a)
lizard
(Anolis carolinensis)
Reptilia STAP2 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stap2 36
  • 50.07 (n)
  • 42.17 (a)
zebrafish
(Danio rerio)
Actinopterygii stap2a 36
  • 55.51 (n)
  • 50 (a)
stap2a 37
  • 37 (a)
OneToMany
stap2b 37
  • 31 (a)
OneToMany
Species with no ortholog for STAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAP2 Gene

ENSEMBL:
Gene Tree for STAP2 (if available)
TreeFam:
Gene Tree for STAP2 (if available)

Paralogs for STAP2 Gene

Paralogs for STAP2 Gene

Selected SIMAP similar genes for STAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STAP2: view

Variants for STAP2 Gene

Sequence variations from dbSNP and Humsavar for STAP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1138253 -- 4,325,436(-) ACCCC(C/T)ATTGG reference, synonymous-codon
rs2002349 -- 4,325,118(-) TCTGT(C/T)GCCCA intron-variant
rs2002350 -- 4,324,917(-) GACCT(C/T)GTGAT intron-variant
rs2002351 -- 4,324,862(-) CCACC(A/G)CACCC intron-variant
rs3834985 -- 4,338,590(-) CACCT(-/CTCT)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAP2 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
dgv3675n71 CNV Loss 21882294
nsv910824 CNV Gain 21882294
nsv458328 CNV Gain 19166990
nsv833719 CNV Loss 17160897
esv2718005 CNV Deletion 23290073
dgv537e201 CNV Deletion 23290073
esv2718008 CNV Deletion 23290073
esv2718010 CNV Deletion 23290073
esv2718011 CNV Deletion 23290073
esv4291 CNV Deletion 18987735
esv9292 CNV Gain 19470904

Relevant External Links for STAP2 Gene

HapMap Linkage Disequilibrium report
STAP2

Disorders for STAP2 Gene

(1) University of Copenhagen DISEASES for STAP2 Gene

Relevant External Links for STAP2

Genetic Association Database (GAD)
STAP2
Human Genome Epidemiology (HuGE) Navigator
STAP2
genes like me logo Genes that share disorders with STAP2: view

No data available for UniProtKB/Swiss-Prot for STAP2 Gene

Publications for STAP2 Gene

  1. A novel adaptor-like protein which is a substrate for the non- receptor tyrosine kinase, BRK. (PMID: 10980601) Mitchell P.J. … Crompton M.R. (Oncogene 2000) 2 3 4 23
  2. STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk- mediated STAT3 activation. (PMID: 19393627) Ikeda O. … Matsuda T. (Biochem. Biophys. Res. Commun. 2009) 3 4 23
  3. The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. (PMID: 19401194) Sekine Y. … Matsuda T. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. (PMID: 19933863) Sekine Y. … Matsuda T. (J. Immunol. 2009) 3 23
  5. Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. (PMID: 16365431) Sekine Y. … Matsuda T. (J. Immunol. 2006) 3 23

Products for STAP2 Gene

Sources for STAP2 Gene

Back to Top

Content