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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAP1 Gene

protein-coding GIFtS: 57
GCID: GC04P068424

signal transducing adaptor family member 1

Explore 1 disease affiliated with
STAP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Transducing Adaptor Family Member 1¹ ²		BCR Downstream-Signaling Protein 1² ³
BRDG1¹ ² ³		BCR Downstream Signaling 1²
STAP-1¹ ² ³		Signal-Transducing Adaptor Protein 1²
Docking Protein BRDG1² ³		Signal-Transducing Adaptor Protein-1²
Stem Cell Adaptor Protein 1² ³

External Ids:	HGNC: 24133¹	Entrez Gene: 26228²	Ensembl: ENSG00000035720⁷	OMIM: 604298⁵	UniProtKB: Q9ULZ2³

Export aliases for STAP1 gene to outside databases

Previous GC identifers: GC04P068108 GC04P064337

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAP1:

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell

antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive

feedback loop, increasing Tec activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STAP1_HUMAN, Q9ULZ2

Function: In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a

positive feedback loop by increasing the activity of TEC

Gene Wiki entry for STAP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAP1 gene promoter:
HSF1 (long) FOXD1 STAT5A HNF-1A MEF-2A S8 HNF-1 HSF1short aMEF-2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAP1 promoter sequence

Search SABiosciences Chromatin IP Primers for STAP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2 Ensembl cytogenetic band: 4q13.2 HGNC cytogenetic band: 4q13.2

STAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAP1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P068424: view genomic region (about GC identifiers)

Start:	68,424,446 bp from pter	End:	68,473,055 bp from pter
Size:	48,610 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAP1_HUMAN, Q9ULZ2 (See protein sequence)

Recommended Name: Signal-transducing adaptor protein 1

Size: 295 amino acids; 34291 Da

Subunit: Interacts with KIT and CSF1R (By similarity). Interacts with URI1; the interaction is

phosphorylation-dependent and occurs in a growth-dependent manner

Subcellular location: Nucleus. Cytoplasm. Mitochondrion

2 PDB 3D structures from and Proteopedia for STAP1:

1X1F (3D)

3MAZ (3D)

Secondary accessions: B2R980

Explore the universe of human proteins at neXtProt for STAP1: NX_Q9ULZ2

Post-translational modifications:

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULZ2

STAP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036240.1

ENSEMBL proteins:

ENSP00000265404 ENSP00000379527

Human Recombinant Protein Products for STAP1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals STAP1 Proteins Novus Biologicals STAP1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for STAP1
	Uscn Proteins for STAP1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	17936702
GO:0005739	mitochondrion	IDA	17936702

STAP1 for ontologies About GeneDecksing

STAP1 Antibody Products:

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Assay Products for STAP1:

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	GenScript Custom Assay Services for STAP1
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	Uscn ELISAs and CLIAs for STAP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAP1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR000980 SH2

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q9ULZ2

ProtoNet protein and cluster: Q9ULZ2

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: STAP1_HUMAN, Q9ULZ2

Similarity: Contains 1 PH domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: STAP1_HUMAN, Q9ULZ2

Function: In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a

positive feedback loop by increasing the activity of TEC

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	IEA	--
GO:0005515	protein binding	IPI	17936702
GO:0005543	phospholipid binding	IEA	--

STAP1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for STAP1:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STAP1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAP1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate STAP1:
		hsa-miR-708*
		SwitchGear 3'UTR luciferase reporter plasmid: STAP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for STAP1
			Sirion Biotech Customized adenovirus for overexpression of STAP1 Sirion Biotech Customized adenovirus for potent knockdown of STAP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAP1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling events mediated by Stem cell factor receptor (c-Kit)

Signaling events mediated by Stem cell factor receptor (c-Kit)

1.00

Kit Receptor Signaling Pathway

0.37

B Cell Receptor Signaling Pathway

B Cell Receptor Signaling Pathway

1.00

3 BioSystems Pathways for STAP1

	B Cell Receptor Signaling Pathway
	Kit Receptor Signaling Pathway
	Signaling events mediated by Stem cell factor receptor (c-Kit)

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STAP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for STAP1 (Q9ULZ2^{2, 3} ENSP00000265404⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3KBP1	Q96B97²^,³, ENSP00000380921⁴	MINT-8109771 MINT-8109802 MINT-8109784 I2D: score=2 STRING: ENSP00000380921
KIT	P10721³, ENSP00000288135⁴	I2D: score=2 STRING: ENSP00000288135
URI1	O94763³, ENSP00000376097⁴	I2D: score=2 STRING: ENSP00000376097
PFDN4	Q9NQP4³, ENSP00000360473⁴	I2D: score=1 STRING: ENSP00000360473
POLR2E	P19388³, ENSP00000215587⁴	I2D: score=1 STRING: ENSP00000215587

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	TAS	10518561
GO:0006944	cellular membrane fusion	TAS	10518561
GO:0007165	signal transduction	TAS	10518561
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--

STAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAP1
Search CenterWatch for drugs/clinical trials and news about STAP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAP1 gene:

NM_012108.2

Unigene Cluster for STAP1:

Signal transducing adaptor family member 1

Hs.435579 [show with all ESTs]

Unigene Representative Sequence: NM_012108

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265404(uc003hde.4) ENST00000396225(uc003hdf.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAP1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate STAP1:
		hsa-miR-708*
		SwitchGear 3'UTR luciferase reporter plasmid: STAP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against STAP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAP1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAP1 (NM_012108)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAP1

Additional cDNA sequence:

AB023483.1 AK313676.1 BC014958.1

4 DOTS entries:

DT.103284 DT.100737067 DT.70105368 DT.92418725

24/45 AceView cDNA sequences (see all 45):

BQ027647 BQ061797 BI261386 BQ065848 AI864505 BC014958 BQ065638 BQ003940

AI796408 BU183172 AI289185 BE326685 BG213994 BU166201 BG755532 NM_012108

AI627673 BG759723 BG190231 AI799271 BP368621 AA760861 BQ003527 AI241023

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATACAATG

About this image

STAP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAP1

SOURCE GeneReport for Unigene cluster: Hs.435579

SABiosciences Custom PCR Arrays for STAP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAP1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for STAP1 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STAP1¹	signal transducing adaptor family member 1	62.89(n) 54.72(a)		428761 XM_426317.3 XP_426317.3
zebrafish (Danio rerio)	Actinopterygii	stap2b¹	signal transducing adaptor family member 2b	48.81(n) 39.33(a)		406601 NM_213309.1 NP_998474.1

ENSEMBL Gene Tree for STAP1 (if available)
TreeFam Gene Tree for STAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAP1 gene

STAP2²

1 SIMAP similar gene for STAP1 using alignment to 1 protein entry: STAP1_HUMAN:

STAP2

STAP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189237152^1,2		--	68422506(+)	`TGAAGG/TTTGGG`	1	--	us2k¹		0	--	--	--	--
rs192145204^1,2		--	68422523(+)	`GAAGCA/GGGTCT`	1	--	us2k¹		0	--	--	--	--
rs184988465^1,2		--	68422656(+)	`GTTCTA/GCCTCA`	1	--	us2k¹		0	--	--	--	--
rs76156437^1,2		--	68422671(+)	`GTAGAC/GAATTT`	1	--	us2k¹		2		CSA WA	120
rs189892756^1,2		--	68422832(+)	`TTCTAA/CATCTA`	1	--	us2k¹		0	--	--	--	--
rs113944457^1,2		--	68422880(+)	`GTAGAT/AATTCT`	1	--	us2k¹		1		CSA	2
rs139066068^1,2		--	68422884(+)	`AAATTC/TTTAGG`	1	--	us2k¹		0	--	--	--	--
rs3806810^1,2	C,F,H	--	68422952(-)	`GTAGCA/GCAGTG`	1	--	us2k¹		15		NS EA WA NA	2334
rs186180776^1,2		--	68422953(+)	`ACTGTA/GCTACG`	1	--	us2k¹		0	--	--	--	--
rs111808697^1,2		--	68423043(+)	`CACTAG/AATAAC`	1	--	us2k¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for STAP1 (68424446 - 68473055 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STAP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAP1

DNA2.0 Custom Variant and Variant Library Synthesis for STAP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STAP1 for disorders           About GeneDecksing

OMIM gene information: 604298    OMIM disorders: --

1 disease for STAP1:    About MalaCards

parkinson's disease

Human Genome Epidemiology (HuGE) Navigator: STAP1 (2 documents)

Export disorders for STAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for STAP1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with STAP1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (PubMed id 10518561)^{1, 2, 3, 9} Ohya K.... Mano H. (1999)
S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PubMed id 17936702)^{1, 2} Djouder N....Krek W. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. (PubMed id 10679268)^{1, 3} Masuhara M....Osawa M. (2000)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Blood pressure is regulated by an alpha1D-adrenergic r eceptor/dystrophin signalosome. (PubMed id 18468998)¹ Lyssand J.S....Hague C. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PubMed id 16806233)¹ Ma J....Liew C.C. (2007)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26228	HGNC: 24133	AceView: BRDG1	Ensembl:ENSG00000035720	euGenes: HUgn26228
ECgene: STAP1	H-InvDB: STAP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STAP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAP1 gene:
Search GeneIP for patents involving STAP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
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	Antibodies for STAP1 (BRDG1)		Browse Cell Culture Products
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	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for STAP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAP1
	OriGene Protein Over-expression Lysate for STAP1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for STAP1		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAP1
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	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for STAP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for STAP1		OriGene Custom Protein Services for STAP1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAP1

	GenScript Custom Purified and Recombinant Proteins Services for STAP1		GenScript cDNA clones with any tag delivered in your preferred vector for STAP1
	GenScript Custom Assay Services for STAP1		GenScript Custom Superior Antibodies Services for STAP1
	GenScript Custom overexpressing Cell Line Services for STAP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search for Antibodies & Assays

	Regulatory tfbs in STAP1 promoter
	Search Chromatin IP Primers for STAP1
	RT² qPCR Primer Assay in human, mouse / rat STAP1
	GNC Network for STAP1
	SABiosciences Custom PCR Arrays for STAP1

Search Tocris compounds for STAP1

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for STAP1
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	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	STAP1 antibodies
	STAP1 proteins
	STAP1 lysates

	Antibodies for STAP1
	See all of Abcam's Antibodies, Kits and Proteins for STAP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for STAP1

STAP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for STAP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAP1

	SwitchGear 3'UTR luciferase reporter plasmids for STAP1
	SwitchGear Promoter luciferase reporter plasmids for STAP1

ThermoFisher Antibodies for STAP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAP1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for STAP1

Sirion Biotech Customized:

	stable knockdown cell line services for STAP1
	inducible knockdown cell line services for STAP1
	design and validation of potent shRNA sequences against STAP1
	adenovirus for potent knockdown of STAP1
	adenovirus for overexpression of STAP1
	stable overexpressing cell line services for STAP1
	inducible overexpressing cell line services for STAP1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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STAP1 Gene

signal transducing adaptor family member 1

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STAP1 Gene

signal transducing adaptor family member 1

Aliasesfor STAP1 gene

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Specialized Databases showing STAP1 gene

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for STAP1 gene

Summaries
for STAP1 gene

Genomic Views
for STAP1 gene

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for STAP1 gene

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Families
for STAP1 gene

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for STAP1 gene

Pathways & Interactions
for STAP1 gene

Drugs & Compounds
for STAP1 gene

Transcripts
for STAP1 gene

Expression
for STAP1 gene

Orthologs
for STAP1 gene

Paralogs
for STAP1 gene

Genomic Variants
for STAP1 gene

Disorders / Diseases
for STAP1 gene

Publications
for STAP1 gene

Intellectual Property
for STAP1 gene

Products
for STAP1 gene