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Aliases for STAP1 Gene

Aliases for STAP1 Gene

  • Signal Transducing Adaptor Family Member 1 2 3
  • BCR Downstream-Signaling Protein 1 3 4
  • Stem Cell Adaptor Protein 1 3 4
  • BCR Downstream Signaling 1 2 3
  • Docking Protein BRDG1 3 4
  • STAP-1 3 4
  • BRDG1 3 4
  • Signal-Transducing Adaptor Protein 1 3
  • Signal-Transducing Adaptor Protein-1 3

External Ids for STAP1 Gene

Previous GeneCards Identifiers for STAP1 Gene

  • GC04P068108
  • GC04P068424
  • GC04P064337

Summaries for STAP1 Gene

Entrez Gene Summary for STAP1 Gene

  • The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAP1 Gene

STAP1 (Signal Transducing Adaptor Family Member 1) is a Protein Coding gene. Among its related pathways are Kit Receptor Signaling Pathway and B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include phospholipid binding and SH3/SH2 adaptor activity. An important paralog of this gene is STAP2.

UniProtKB/Swiss-Prot for STAP1 Gene

  • In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.

Gene Wiki entry for STAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAP1 Gene

Genomics for STAP1 Gene

Regulatory Elements for STAP1 Gene

Genomic Location for STAP1 Gene

Start:
67,558,728 bp from pter
End:
67,607,341 bp from pter
Size:
48,614 bases
Orientation:
Plus strand

Genomic View for STAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAP1 Gene

Proteins for STAP1 Gene

  • Protein details for STAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULZ2-STAP1_HUMAN
    Recommended name:
    Signal-transducing adaptor protein 1
    Protein Accession:
    Q9ULZ2
    Secondary Accessions:
    • B2R980

    Protein attributes for STAP1 Gene

    Size:
    295 amino acids
    Molecular mass:
    34291 Da
    Quaternary structure:
    • Interacts with KIT and CSF1R (By similarity). Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.

    Three dimensional structures from OCA and Proteopedia for STAP1 Gene

neXtProt entry for STAP1 Gene

Proteomics data for STAP1 Gene at MOPED

Post-translational modifications for STAP1 Gene

  • Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STAP1 Gene

Domains for STAP1 Gene

Gene Families for STAP1 Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for STAP1 Gene

Suggested Antigen Peptide Sequences for STAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULZ2

UniProtKB/Swiss-Prot:

STAP1_HUMAN :
  • Q9ULZ2
Domain:
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with STAP1: view

Function for STAP1 Gene

Molecular function for STAP1 Gene

UniProtKB/Swiss-Prot Function: In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.

Gene Ontology (GO) - Molecular Function for STAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20442417
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity ISS --
GO:0005070 SH3/SH2 adaptor activity IPI 10518561
GO:0005515 protein binding IPI 15090612
GO:0005543 phospholipid binding NAS 10518561
genes like me logo Genes that share ontologies with STAP1: view

Phenotypes for STAP1 Gene

GenomeRNAi human phenotypes for STAP1:
genes like me logo Genes that share phenotypes with STAP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for STAP1 Gene

Localization for STAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAP1 Gene

Nucleus. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAP1 Gene COMPARTMENTS Subcellular localization image for STAP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for STAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17936702
GO:0005737 cytoplasm IDA 17936702
GO:0005739 mitochondrion IDA 17936702
GO:0043234 protein complex IDA 18468998
genes like me logo Genes that share ontologies with STAP1: view

Pathways for STAP1 Gene

genes like me logo Genes that share pathways with STAP1: view

Gene Ontology (GO) - Biological Process for STAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0007165 signal transduction --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS --
GO:0009967 positive regulation of signal transduction --
GO:0010628 positive regulation of gene expression ISS --
genes like me logo Genes that share ontologies with STAP1: view

Transcripts for STAP1 Gene

mRNA/cDNA for STAP1 Gene

Unigene Clusters for STAP1 Gene

Signal transducing adaptor family member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAP1 Gene

No ASD Table

Relevant External Links for STAP1 Gene

GeneLoc Exon Structure for
STAP1
ECgene alternative splicing isoforms for
STAP1

Expression for STAP1 Gene

mRNA expression in normal human tissues for STAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAP1 Gene

This gene is overexpressed in Spleen (7.8) and Kidney - Cortex (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for STAP1 Gene

SOURCE GeneReport for Unigene cluster for STAP1 Gene Hs.435579

genes like me logo Genes that share expressions with STAP1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for STAP1 Gene

Orthologs for STAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAP1 35
  • 99.55 (n)
  • 99.66 (a)
STAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAP1 35
  • 90.96 (n)
  • 87.91 (a)
STAP1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAP1 35
  • 88.28 (n)
  • 85.86 (a)
STAP1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stap1 35
  • 84.52 (n)
  • 83.73 (a)
Stap1 16
Stap1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAP1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAP1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stap1 35
  • 85.42 (n)
  • 85.42 (a)
chicken
(Gallus gallus)
Aves STAP1 35
  • 62.8 (n)
  • 54.31 (a)
STAP1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stap1 35
  • 55.56 (n)
  • 45.59 (a)
Species with no ortholog for STAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STAP1 Gene

ENSEMBL:
Gene Tree for STAP1 (if available)
TreeFam:
Gene Tree for STAP1 (if available)

Paralogs for STAP1 Gene

Paralogs for STAP1 Gene

Selected SIMAP similar genes for STAP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STAP1: view

Variants for STAP1 Gene

Sequence variations from dbSNP and Humsavar for STAP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs354874 -- 67,601,836(+) tgagt(G/T)aaatc intron-variant
rs354875 -- 67,601,935(+) tctac(A/G)ttgat intron-variant
rs354876 -- 67,601,967(+) aagac(C/T)agtaa intron-variant
rs354877 -- 67,602,302(+) tttac(C/T)gtctg intron-variant
rs354878 -- 67,602,510(+) aaaaa(A/G)aattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAP1 Gene

Variant ID Type Subtype PubMed ID
nsv879214 CNV Gain 21882294
nsv879215 CNV Loss 21882294
nsv879216 CNV Loss 21882294
esv2660163 CNV Deletion 23128226

Relevant External Links for STAP1 Gene

HapMap Linkage Disequilibrium report
STAP1
Human Gene Mutation Database (HGMD)
STAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAP1 Gene

Disorders for STAP1 Gene

Relevant External Links for STAP1

Genetic Association Database (GAD)
STAP1
Human Genome Epidemiology (HuGE) Navigator
STAP1
genes like me logo Genes that share disorders with STAP1: view

No data available for UniProtKB/Swiss-Prot for STAP1 Gene

Publications for STAP1 Gene

  1. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (PMID: 10518561) Ohya K. … Mano H. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. (PMID: 10679268) Masuhara M. … Osawa M. (Biochem. Biophys. Res. Commun. 2000) 2 3
  4. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PMID: 17052657) Fung H.C. … Singleton A. (Lancet Neurol 2006) 3 48
  5. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PMID: 17936702) Djouder N. … Krek W. (Mol. Cell 2007) 3 4

Products for STAP1 Gene

Sources for STAP1 Gene

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