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Aliases for STAMBPL1 Gene

Aliases for STAMBPL1 Gene

  • STAM Binding Protein Like 1 2 3 5
  • Associated Molecule With The SH3 Domain Of STAM (AMSH) - Family Protein 2 3
  • Associated Molecule With The SH3 Domain Of STAM (AMSH) Like Protein 2 3
  • AMSH-LP 3 4
  • STAM Binding Protein-Like 1 2
  • STAM-Binding Protein-Like 1 4
  • AMSH-Like Protease 3
  • EC 3.1.2.15 61
  • EC 3.4.19.- 4
  • BA399O19.2 3
  • ALMalpha 3
  • KIAA1373 4
  • AMSH-FP 3
  • AMSHLP 4

External Ids for STAMBPL1 Gene

Previous GeneCards Identifiers for STAMBPL1 Gene

  • GC10P090630
  • GC10P084274

Summaries for STAMBPL1 Gene

GeneCards Summary for STAMBPL1 Gene

STAMBPL1 (STAM Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is STAMBP.

UniProtKB/Swiss-Prot for STAMBPL1 Gene

  • Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains.

Gene Wiki entry for STAMBPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAMBPL1 Gene

Genomics for STAMBPL1 Gene

Regulatory Elements for STAMBPL1 Gene

Enhancers for STAMBPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G088878 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +4.8 4848 10.9 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 STAMBPL1 FAS ACTA2-AS1 RPL11P3 RNLS ENSG00000201548 LIPJ LIPM LIPN ANKRD22
GH10G088840 1.1 FANTOM5 Ensembl ENCODE 17.8 -38.6 -38612 1.5 JUND ATF3 TAF1 MAX ZBTB33 GABPA YY1 ANKRD22 STAMBPL1 ACTA2-AS1 FAS LIPM IFIT3 IFIT2 LIPN
GH10G088892 1.5 Ensembl ENCODE dbSUPER 11.6 +19.0 18962 12.6 HDGF PKNOX1 FEZF1 FOS JUNB PPARG TBX21 GLIS1 STAT3 NBN STAMBPL1 ACTA2-AS1 ANKRD22 FAS LIPM LIPJ RNLS ENSG00000201548 IFIT1B
GH10G088850 1.4 FANTOM5 Ensembl ENCODE 11.7 -27.3 -27268 4.2 SIX4 PKNOX1 MAX RFX5 CTBP1 NFYB EED FOSL2 FOS ZNF600 ANKRD22 STAMBPL1 IFIT3 IFIT2 PTCD2P2
GH10G088931 1.4 Ensembl ENCODE dbSUPER 11.5 +53.2 53205 2.6 PKNOX1 BRCA1 ZNF2 RAD21 RFX5 YY1 SCRT2 ZNF143 RCOR1 DEK STAMBPL1 LIPN LIPM ACTA2-AS1 FAS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STAMBPL1 on UCSC Golden Path with GeneCards custom track

Promoters for STAMBPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000031253 1432 2001 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for STAMBPL1 Gene

Chromosome:
10
Start:
88,879,368 bp from pter
End:
88,975,153 bp from pter
Size:
95,786 bases
Orientation:
Plus strand

Genomic View for STAMBPL1 Gene

Genes around STAMBPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAMBPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAMBPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAMBPL1 Gene

Proteins for STAMBPL1 Gene

  • Protein details for STAMBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FJ0-STALP_HUMAN
    Recommended name:
    AMSH-like protease
    Protein Accession:
    Q96FJ0
    Secondary Accessions:
    • B3KPA7
    • Q5T9N4
    • Q5T9N9
    • Q7Z420
    • Q9P2H4

    Protein attributes for STAMBPL1 Gene

    Size:
    436 amino acids
    Molecular mass:
    49783 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92611.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STAMBPL1 Gene

    Alternative splice isoforms for STAMBPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAMBPL1 Gene

Selected DME Specific Peptides for STAMBPL1 Gene

Q96FJ0:
  • ETCGILCGKL
  • SSVDLHTHCSYQ

Post-translational modifications for STAMBPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for STAMBPL1 Gene

Protein Domains for STAMBPL1 Gene

Suggested Antigen Peptide Sequences for STAMBPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FJ0

UniProtKB/Swiss-Prot:

STALP_HUMAN :
  • The JAMM motif is essential for the protease activity.
  • Belongs to the peptidase M67C family.
Domain:
  • The JAMM motif is essential for the protease activity.
Family:
  • Belongs to the peptidase M67C family.
genes like me logo Genes that share domains with STAMBPL1: view

No data available for Gene Families for STAMBPL1 Gene

Function for STAMBPL1 Gene

Molecular function for STAMBPL1 Gene

UniProtKB/Swiss-Prot Function:
Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for STAMBPL1 Gene

Gene Ontology (GO) - Molecular Function for STAMBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAMBPL1: view
genes like me logo Genes that share phenotypes with STAMBPL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAMBPL1 Gene

Localization for STAMBPL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAMBPL1 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for STAMBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with STAMBPL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STAMBPL1 Gene

Pathways & Interactions for STAMBPL1 Gene

genes like me logo Genes that share pathways with STAMBPL1: view

Pathways by source for STAMBPL1 Gene

1 BioSystems pathway for STAMBPL1 Gene

Gene Ontology (GO) - Biological Process for STAMBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination TAS --
GO:0070536 protein K63-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with STAMBPL1: view

No data available for SIGNOR curated interactions for STAMBPL1 Gene

Drugs & Compounds for STAMBPL1 Gene

No Compound Related Data Available

Transcripts for STAMBPL1 Gene

Unigene Clusters for STAMBPL1 Gene

STAM binding protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAMBPL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for STAMBPL1 Gene

GeneLoc Exon Structure for
STAMBPL1
ECgene alternative splicing isoforms for
STAMBPL1

Expression for STAMBPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAMBPL1 Gene

Protein differential expression in normal tissues from HIPED for STAMBPL1 Gene

This gene is overexpressed in Breast (57.9) and Heart (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STAMBPL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of STAMBPL1 Gene:

STAMBPL1

SOURCE GeneReport for Unigene cluster for STAMBPL1 Gene:

Hs.16229

mRNA Expression by UniProt/SwissProt for STAMBPL1 Gene:

Q96FJ0-STALP_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for STAMBPL1 Gene

  • Nervous system(4.4)
  • Pancreas(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with STAMBPL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAMBPL1 Gene

Orthologs for STAMBPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAMBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAMBPL1 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia STAMBPL1 34 35
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Stambpl1 34 16 35
  • 86.85 (n)
rat
(Rattus norvegicus)
Mammalia Stambpl1 34
  • 86.24 (n)
dog
(Canis familiaris)
Mammalia STAMBPL1 34 35
  • 80.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STAMBPL1 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAMBPL1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAMBPL1 34 35
  • 77.39 (n)
lizard
(Anolis carolinensis)
Reptilia STAMBPL1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stambpl1 34
  • 71.87 (n)
MGC75962 34
zebrafish
(Danio rerio)
Actinopterygii stambpl1 35
  • 67 (a)
OneToOne
LOC570542 34
  • 64.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2224 35
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for STAMBPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAMBPL1 Gene

ENSEMBL:
Gene Tree for STAMBPL1 (if available)
TreeFam:
Gene Tree for STAMBPL1 (if available)

Paralogs for STAMBPL1 Gene

Paralogs for STAMBPL1 Gene

(1) SIMAP similar genes for STAMBPL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STAMBPL1: view

Variants for STAMBPL1 Gene

Sequence variations from dbSNP and Humsavar for STAMBPL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000047198 -- 88,887,278(+) ATCAT(G/T)GGTGG intron-variant
rs1000066976 -- 88,887,818(+) CACCC(A/G)ACAGC intron-variant
rs1000253674 -- 88,907,059(+) GACTA(C/T)TCTCT intron-variant, utr-variant-5-prime
rs1000320145 -- 88,921,098(+) AATTG(C/T)AGTTA intron-variant
rs1000467854 -- 88,894,331(+) GGAAC(A/G)AAAGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for STAMBPL1 Gene

Variant ID Type Subtype PubMed ID
esv3624139 CNV gain 21293372
esv3624143 CNV loss 21293372
esv3624144 CNV gain 21293372
nsv831942 CNV gain 17160897
nsv831943 CNV gain 17160897

Variation tolerance for STAMBPL1 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAMBPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAMBPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAMBPL1 Gene

Disorders for STAMBPL1 Gene

Relevant External Links for STAMBPL1

Genetic Association Database (GAD)
STAMBPL1
Human Genome Epidemiology (HuGE) Navigator
STAMBPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAMBPL1

No disorders were found for STAMBPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAMBPL1 Gene

Publications for STAMBPL1 Gene

  1. Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif. (PMID: 12810066) Kikuchi K. … Sugamura K. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. (PMID: 18758443) Sato Y. … Fukai S. (Nature 2008) 3 4 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. (PMID: 16716190) Nakamura M. … Komada M. (Genes Cells 2006) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for STAMBPL1 Gene

Sources for STAMBPL1 Gene

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