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Aliases for STAMBPL1 Gene

Aliases for STAMBPL1 Gene

  • STAM Binding Protein Like 1 2 3 5
  • Associated Molecule With The SH3 Domain Of STAM (AMSH) - Family Protein 2 3
  • Associated Molecule With The SH3 Domain Of STAM (AMSH) Like Protein 2 3
  • STAM Binding Protein-Like 1 2 3
  • AMSH-LP 3 4
  • STAM-Binding Protein-Like 1 4
  • EC 3.1.2.15 63
  • EC 3.4.19.- 4
  • BA399O19.2 3
  • ALMalpha 3
  • KIAA1373 4
  • AMSH-FP 3
  • AMSHLP 4

External Ids for STAMBPL1 Gene

Previous GeneCards Identifiers for STAMBPL1 Gene

  • GC10P090630
  • GC10P084274

Summaries for STAMBPL1 Gene

GeneCards Summary for STAMBPL1 Gene

STAMBPL1 (STAM Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is STAMBP.

UniProtKB/Swiss-Prot for STAMBPL1 Gene

  • Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains.

Gene Wiki entry for STAMBPL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAMBPL1 Gene

Genomics for STAMBPL1 Gene

Regulatory Elements for STAMBPL1 Gene

Enhancers for STAMBPL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STAMBPL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for STAMBPL1 Gene

Chromosome:
10
Start:
88,879,368 bp from pter
End:
88,975,153 bp from pter
Size:
95,786 bases
Orientation:
Plus strand

Genomic View for STAMBPL1 Gene

Genes around STAMBPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAMBPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAMBPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAMBPL1 Gene

Proteins for STAMBPL1 Gene

  • Protein details for STAMBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FJ0-STALP_HUMAN
    Recommended name:
    AMSH-like protease
    Protein Accession:
    Q96FJ0
    Secondary Accessions:
    • B3KPA7
    • Q5T9N4
    • Q5T9N9
    • Q7Z420
    • Q9P2H4

    Protein attributes for STAMBPL1 Gene

    Size:
    436 amino acids
    Molecular mass:
    49783 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92611.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STAMBPL1 Gene

    Alternative splice isoforms for STAMBPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAMBPL1 Gene

Proteomics data for STAMBPL1 Gene at MOPED

Selected DME Specific Peptides for STAMBPL1 Gene

Post-translational modifications for STAMBPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAMBPL1 Gene

Domains & Families for STAMBPL1 Gene

Protein Domains for STAMBPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STAMBPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FJ0

UniProtKB/Swiss-Prot:

STALP_HUMAN :
  • The JAMM motif is essential for the protease activity.
  • Belongs to the peptidase M67C family.
Domain:
  • The JAMM motif is essential for the protease activity.
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the peptidase M67C family.
genes like me logo Genes that share domains with STAMBPL1: view

No data available for Gene Families for STAMBPL1 Gene

Function for STAMBPL1 Gene

Molecular function for STAMBPL1 Gene

UniProtKB/Swiss-Prot Function:
Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for STAMBPL1 Gene

Gene Ontology (GO) - Molecular Function for STAMBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with STAMBPL1: view
genes like me logo Genes that share phenotypes with STAMBPL1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAMBPL1 Gene

Localization for STAMBPL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAMBPL1 Gene COMPARTMENTS Subcellular localization image for STAMBPL1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
endosome 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STAMBPL1 Gene

Pathways & Interactions for STAMBPL1 Gene

genes like me logo Genes that share pathways with STAMBPL1: view

Pathways by source for STAMBPL1 Gene

1 BioSystems pathway for STAMBPL1 Gene

Gene Ontology (GO) - Biological Process for STAMBPL1 Gene

None

No data available for SIGNOR curated interactions for STAMBPL1 Gene

Drugs & Compounds for STAMBPL1 Gene

No Compound Related Data Available

Transcripts for STAMBPL1 Gene

Unigene Clusters for STAMBPL1 Gene

STAM binding protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAMBPL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for STAMBPL1 Gene

GeneLoc Exon Structure for
STAMBPL1
ECgene alternative splicing isoforms for
STAMBPL1

Expression for STAMBPL1 Gene

mRNA expression in normal human tissues for STAMBPL1 Gene

Protein differential expression in normal tissues from HIPED for STAMBPL1 Gene

This gene is overexpressed in Breast (57.9) and Heart (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAMBPL1 Gene



SOURCE GeneReport for Unigene cluster for STAMBPL1 Gene Hs.16229

mRNA Expression by UniProt/SwissProt for STAMBPL1 Gene

Q96FJ0-STALP_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with STAMBPL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for STAMBPL1 Gene

Orthologs for STAMBPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAMBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAMBPL1 35
  • 90.06 (n)
  • 92.66 (a)
STAMBPL1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAMBPL1 35
  • 80.66 (n)
  • 88.07 (a)
STAMBPL1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stambpl1 35
  • 86.85 (n)
  • 91.06 (a)
Stambpl1 16
Stambpl1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAMBPL1 35
  • 99.85 (n)
  • 99.77 (a)
STAMBPL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stambpl1 35
  • 86.24 (n)
  • 90.83 (a)
oppossum
(Monodelphis domestica)
Mammalia STAMBPL1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAMBPL1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAMBPL1 35
  • 77.39 (n)
  • 79.08 (a)
STAMBPL1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAMBPL1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75962 35
stambpl1 35
  • 71.87 (n)
  • 79.25 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570542 35
  • 64.67 (n)
  • 69.62 (a)
stambpl1 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2224 36
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for STAMBPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAMBPL1 Gene

ENSEMBL:
Gene Tree for STAMBPL1 (if available)
TreeFam:
Gene Tree for STAMBPL1 (if available)

Paralogs for STAMBPL1 Gene

Paralogs for STAMBPL1 Gene

(1) SIMAP similar genes for STAMBPL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STAMBPL1: view

Variants for STAMBPL1 Gene

Sequence variations from dbSNP and Humsavar for STAMBPL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12254856 - 88,913,267(+) GCGAA(A/G)TCAGC reference, missense
rs34270879 - 88,913,290(-) CTGCT(C/T)TGACA reference, missense
rs9988723 - 88,913,308(+) GGAGC(A/G)CTTTG reference, missense
rs1441738 -- 88,917,829(-) ACTTT(A/C)CAGTC intron-variant
rs1441742 -- 88,880,053(+) GTGCA(C/G)GGTTT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for STAMBPL1 Gene

Variant ID Type Subtype PubMed ID
nsv831942 CNV Gain 17160897
nsv831943 CNV Gain 17160897

Variation tolerance for STAMBPL1 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STAMBPL1 Gene

Disorders for STAMBPL1 Gene

Relevant External Links for STAMBPL1

Genetic Association Database (GAD)
STAMBPL1
Human Genome Epidemiology (HuGE) Navigator
STAMBPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAMBPL1

No disorders were found for STAMBPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAMBPL1 Gene

Publications for STAMBPL1 Gene

  1. Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif. (PMID: 12810066) Kikuchi K. … Sugamura K. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. (PMID: 16716190) Nakamura M. … Komada M. (Genes Cells 2006) 3 23
  3. A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells. (PMID: 12943674) Kitajima K. … Nakamura T. (Biochem. Biophys. Res. Commun. 2003) 2 3
  4. Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes. (PMID: 26256234) Zhu W. … Ling B. (Biochemistry 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for STAMBPL1 Gene

Sources for STAMBPL1 Gene

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