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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAMBP Gene

protein-coding   GIFtS: 61
GCID: GC02P074056

STAM binding protein

 Explore 3 diseases affiliated with
STAMBP via our new
 Human Malady Compendium 
Biological research products
for STAMBP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
STAM Binding Protein1 2     STAM-Binding Protein2
AMSH1 2 3 5     EC 3.4.19.-3
Associated Molecule With The SH3 Domain Of STAM2 3     EC 3.1.2.158
Endosome-Associated Ubiquitin Isopeptidase2 3     

External Ids:    HGNC: 169501   Entrez Gene: 106172   Ensembl: ENSG000001243567   OMIM: 6062475   UniProtKB: O956303   

Export aliases for STAMBP gene to outside databases

Previous GC identifers: GC02P074030 GC02P073968 GC02P073791


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAMBP:
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such
signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The
protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical
role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced
transcript variants encoding the same protein isoform have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STABP_HUMAN, O95630
Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave
'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the
ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC
induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the
inhibitory action of SMAD6 and SMAD7

Gene Wiki entry for STAMBP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAMBP gene promoter:
         AML1a   Ik-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAMBP promoter sequence
   Search SABiosciences Chromatin IP Primers for STAMBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAMBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p24.3-p24.1

STAMBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAMBP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074056:  view genomic region     (about GC identifiers)

Start:
74,056,086 bp from pter      End:
74,100,786 bp from pter
Size:
44,701 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STABP_HUMAN, O95630 (See protein sequence)
Recommended Name: STAM-binding protein  
Size: 424 amino acids; 48077 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subunit: Interacts with STAM1. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve
the autoinhibition of CHMP3. Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination
Subcellular location: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome
Miscellaneous: X-ray crystallography studies of STAMBPL1, another member of the peptidase M67C family, has shown that
Glu-280 binds zinc indirectly via a water molecule. Nevertheless, this residue is essential for catalytic activity
3 PDB 3D structures from and Proteopedia for STAMBP:
2XZE (3D)        3RZU (3D)        3RZV (3D)    
Secondary accessions: D6W5H7 Q3MJE7

Explore the universe of human proteins at neXtProt for STAMBP: NX_O95630

Post-translational modifications:

  • Phosphorylated after BMP type I receptor activation1
  • Ubiquitinated by SMURF2 in the presence of RNF111
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95630

  • 4/5 DME Specific Peptides for STAMBP (O95630) (see all 5)
     CRQKGFHPH  ETCGILCGKL  SSVDLHTHCSYQ  AIVCSPKFQETGFFKLTD 

    STAMBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_006454.1  NP_964010.1  NP_998787.1  

    ENSEMBL proteins: 
     ENSP00000386548   ENSP00000413291   ENSP00000413874   ENSP00000390921   ENSP00000377633  
     ENSP00000443502   ENSP00000344742   ENSP00000377636  

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    Uscn Proteins for STAMBP

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane IDA--


    STAMBP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STAMBP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000555 JAB1_Mov34_MPN_PAD1

    Graphical View of Domain Structure for InterPro Entry O95630

    ProtoNet protein and cluster: O95630

    1 Blocks protein family: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: STABP_HUMAN, O95630
    Domain: The JAMM motif is essential for the protease activity (By similarity)
    Similarity: Belongs to the peptidase M67C family
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: STABP_HUMAN, O95630
    Function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave
    'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the
    ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC
    induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the
    inhibitory action of SMAD6 and SMAD7
    Enzyme regulation: Inhibited by N-ethylmaleimide

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.-1

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA18388320
    GO:0005515protein binding IPI--
    GO:0008237metallopeptidase activity IEA--
    GO:0046872metal ion binding IEA--


    STAMBP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for STAMBP:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Stambptm1Sug for STAMBP
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stambp):
     behavior/neurological  growth/size  immune system  mortality/aging  nervous system 
     vision/eye 

    STAMBP for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Internalization of ErbB1
    Internalization of ErbB11.00
    2Endocytosis
    Endocytosis1.00
    3Protein Stability
    Protein Stability1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for STAMBP
        Protein Stability

    1 BioSystems Pathway for STAMBP 
        Internalization of ErbB1


    1         Kegg Pathway  (Kegg details for STAMBP):
        Endocytosis


    STAMBP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAMBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for STAMBP (O956301, 2, 3 ENSP000003447424) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP3Q9Y3E71, 3, ENSP000002638564EBI-396676,EBI-2563192 I2D: score=8 STRING: ENSP00000263856
    GRB2P629931, 3, ENSP000003390074EBI-396676,EBI-401755 I2D: score=4 STRING: ENSP00000339007
    CHMP1AQ9HD421, 3, ENSP000002534754EBI-396676,EBI-1057156 I2D: score=2 STRING: ENSP00000253475
    CHMP5Q9NZZ31, 3, ENSP000002235004EBI-396676,EBI-751303 I2D: score=1 STRING: ENSP00000223500
    RECQL5O947622, 3MINT-63230 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281cytokinesis after mitosis IMP18388320
    GO:0006508proteolysis IEA--
    GO:0007259JAK-STAT cascade TAS10383417
    GO:0008284positive regulation of cell proliferation TAS10383417
    GO:0016579protein deubiquitination IMP18388320


    STAMBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STAMBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for STAMBP

    1 HMDB Compound for STAMBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    1 Novoseek chemical compound relationship for STAMBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 96.2 18 17078930 (4), 15314065 (2), 16716190 (2), 16520378 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about STAMBP / STABP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STAMBP gene (3 alternative transcripts): 
    NM_006463.4  NM_201647.2  NM_213622.2  

    Unigene Cluster for STAMBP:

    STAM binding protein
    Hs.469018  [show with all ESTs]
    Unigene Representative Sequence: NM_213622
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409707 ENST00000452725 ENST00000432295 ENST00000424659 ENST00000394070(uc002sjs.3 uc002sju.3 uc002sjv.3)
    ENST00000536064 ENST00000478946 ENST00000486458 ENST00000487811 ENST00000339566
    ENST00000394073

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    hsa-miR-607 hsa-miR-938 hsa-miR-3916 hsa-miR-3148 hsa-miR-490-3p hsa-miR-548b-3p hsa-miR-224* hsa-miR-645
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    Additional cDNA sequence: 

    AF052135.1 AK023768.1 BC007682.1 BC065574.1 BC101467.1 BC101469.1 EU927390.1 U73522.1 

    11 DOTS entries:

    DT.86853374  DT.448971  DT.409248  DT.101964211  DT.437226  DT.100026770  DT.100806523  DT.91682782 
    DT.91860569  DT.92439811  DT.40124680 

    24/55 AceView cDNA sequences (see all 55):

    AI421353 BU624695 AI051561 AW955215 CB131723 AL702850 AW294318 AA156537 
    CA447246 BM998025 CR604826 CA423304 AA324651 AI560177 BU622410 BX432968 
    BX432967 AL705488 BE743911 BX502127 BE898388 AL516207 CB132205 BM473469 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for STAMBP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                  -                                                                 -               
    SP2:                                                  -                                                                                 
    SP3:                                                                                                                                    
    SP4:        -     -     -                             -                                                                                 
    SP5:                    -                             -                                                                                 


    ECgene alternative splicing isoforms for STAMBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAMBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCACCCAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See STAMBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAMBP

    SOURCE GeneReport for Unigene cluster: Hs.469018

    UniProtKB/Swiss-Prot: STABP_HUMAN, O95630
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including STAMBP: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STAMBP gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves STAMBP6
    Uncharacterized protein
    74(a)
    1 ↔ 1
    22(2822645-2835389)
    lizard
    (Anolis carolinensis)
    Reptilia STAMBP6
    --
    72(a)
    1 ↔ 1
    GL343608.1(264381-279894)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35272 Xenopus laevis transcribed sequence with weak similarity more 74.44(n)    CA792378.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661472 hypothetical protein MGC66147 74.19(n)   393470  AY398309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22241 CG2224 52.6(n)
    48.08(a)
      43617  NM_143539.2  NP_651796.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AMSH26
    AMSH36
    (see all 3)
    AMSH-like ubiquitin thiolesterase 3
    (see all 3)
    35(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(3503704-3505502)
    4(9137789-9141572)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 4)
    mov34/MPN/PAD-1 family protein, expressed
    (see all 4)
    29(a)
    25(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    1(27007759-27011070)
    1(17209209-17217264)


    ENSEMBL Gene Tree for STAMBP (if available)
    TreeFam Gene Tree for STAMBP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAMBP gene
    STAMBPL12  
    1 SIMAP similar gene for STAMBP using alignment to 7 protein entries:     STABP_HUMAN (see all proteins):
    STAMBPL1

    STAMBP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for STAMBP
    PGOHUM00000233524


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/647 NCBI SNPs in STAMBP are shown (see all 647    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906484231,2
    --74054115(+) ATTTTC/TACCTT 2 -- us2k10--------
    rs1834834941,2
    --74054163(+) AGTATC/TGAACT 3 -- us2k10--------
    rs729154811,2
    C,--74054174(+) TTGCCC/TCAGAT 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1474152381,2
    --74054254(+) TTAGCG/TATTAC 3 -- us2k10--------
    rs170093961,2
    C,F,H,--74054272(+) ACTGCT/CAGCAA 3 -- us2k122Minor allele frequency- C:0.15NA NS EA WA CSA 2359
    rs1880778341,2
    --74054337(+) GTTTAC/TGACTA 3 -- us2k10--------
    rs1912944851,2
    --74054340(+) TACGAC/TTATGC 3 -- us2k10--------
    rs1829343721,2
    --74054343(+) GACTAG/TGCACA 3 -- us2k10--------
    rs1879824011,2
    --74054392(+) CTTCTA/CATCAT 3 -- us2k10--------
    rs1914202701,2
    --74054397(+) CATCAC/TAATCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for STAMBP (74056086 - 74100786 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for STAMBP
         2 CNVs: 3365 35853

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    DNA2.0 Custom Variant and Variant Library Synthesis for STAMBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STAMBP for disorders           About GeneDecksing

    OMIM gene information: 606247    OMIM disorders: --

    3 diseases for STAMBP:    About MalaCards
    breast cancer    cerebritis    neuronitis


    Export disorders for STAMBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAMBP gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with STAMBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines. (PubMed id 10383417)1, 2, 3 Tanaka N.... Sugamura K. (1999)
    2. AMSH is an endosome-associated ubiquitin isopeptidase. (PubMed id 15314065)1, 2, 9 McCullough J.... Urbe S. (2004)
    3. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PubMed id 17261583)1, 2, 9 Ma Y.M.... Kirchhausen T. (2007)
    4. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. (PubMed id 11483516)1, 2, 9 Itoh F.... Itoh S. (2001)
    5. Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding. (PubMed id 17146056)1, 2 Zamborlini A....Gottlinger H. (2006)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    7. An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. (PubMed id 14755250)1, 2 Li H. and Seth A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. (PubMed id 12370088)1, 2 Maytal-Kivity V.... Glickman M.H. (2002)
    10. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. (PubMed id 16716190)1, 9 Nakamura M....Komada M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10617 HGNC: 16950 AceView: STAMBP.1 Ensembl:ENSG00000124356 euGenes: HUgn10617
    ECgene: STAMBP Kegg: 10617 H-InvDB: STAMBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAMBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STAMBP gene:
    Search GeneIP for patents involving STAMBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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