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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

STAM2 Gene

protein-coding GIFtS: 61
GCID: GC02M152939

signal transducing adaptor molecule (SH3 domain and ITAM...

Explore 2 diseases affiliated with
STAM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 2¹ ²		STAM2B²
Hbp¹ ²		HSE1 Homolog²
STAM-2² ³		Signal Transducing Adapter Molecule 2²
Hrs-Binding Protein² ³		STAM-Like Protein Containing SH3 And ITAM Domains 2²
STAM2A²		HBP³

External Ids:	HGNC: 11358¹	Entrez Gene: 10254²	Ensembl: ENSG00000115145⁷	OMIM: 606244⁵	UniProtKB: O75886³

Export aliases for STAM2 gene to outside databases

Previous GC identifers: GC02M150726 GC02M151504 GC02M153177 GC02M152800 GC02M152683 GC02M144859

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAM2:

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of

cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM).

Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine

stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway

downstream of JAK kinases upon cytokine stimulation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886

Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL

stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell

development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed

with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes

ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By

similarity)

Gene Wiki entry for STAM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STAM2 gene promoter:
HFH-3 CUTL1 LCR-F1 Evi-1 E47 c-Ets-1 FOXI1 POU2F1 POU2F1a Hand1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAM2 promoter sequence

Search SABiosciences Chromatin IP Primers for STAM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q23.3

STAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAM2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M152939: view genomic region (about GC identifiers)

Start:	152,973,315 bp from pter	End:	153,032,506 bp from pter
Size:	59,192 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886 (See protein sequence)

Recommended Name: Signal transducing adapter molecule 2

Size: 525 amino acids; 58164 Da

Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of

HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating

enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct.

Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct

Subcellular location: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side

3 PDB 3D structures from and Proteopedia for STAM2:

1X2Q (3D)

1X5B (3D)

2L0T (3D)

Secondary accessions: A8K8A0 D3DPA1 Q7LDQ0 Q9UF58

Alternative splicing: 2 isoforms: O75886-1 O75886-2

Explore the universe of human proteins at neXtProt for STAM2: NX_O75886

Post-translational modifications:

Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75886

STAM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005834.4

ENSEMBL proteins:

ENSP00000263904

Reactome Protein details: O75886
Human Recombinant Protein Products:

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	Novus Biologicals STAM2 Proteins Novus Biologicals STAM2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for STAM2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0031901	early endosome membrane	IEA	--

STAM2 for ontologies About GeneDecksing

STAM2 Antibody Products:

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	ThermoFisher Antibodies for STAM2

Assay Products for STAM2:

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	Uscn ELISAs and CLIAs for STAM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STAM2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR002014 VHS

IPR018205 VHS_subgr

IPR008942 ENTH_VHS

IPR000108 p67phox

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry O75886

ProtoNet protein and cluster: O75886

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB002014 VHS

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886

Domain: The VHS and UIM domains mediate the interaction with ubiquitinated proteins

Domain: The SH3 domain mediates the interaction with USP8

Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains.

This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain

Similarity: Belongs to the STAM family

Similarity: Contains 1 ITAM domain

Similarity: Contains 1 SH3 domain

Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat

Similarity: Contains 1 VHS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886

Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL

stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell

development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed

with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes

ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By

similarity)

miRNA Products:		miRTarBase miRNAs that target STAM2: hsa-mir-218 (MIRT005005)

		OriGene 3'-UTR Clone: STAM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAM2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate STAM2 (see all 36):
		hsa-miR-219-1-3p hsa-miR-607 hsa-miR-218 hsa-miR-570 hsa-miR-298 hsa-miR-2113 hsa-miR-3163 hsa-miR-548e

		SwitchGear 3'UTR luciferase reporter plasmid: STAM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAM2 (see all 7) OriGene shRNA RFP: STAM2 OriGene siRNA: STAM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for STAM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAM2 (NM_005843)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for STAM2
		Search LifeMap BioReagents cell lines for STAM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAM2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19060904

STAM2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for STAM2:

Decreased TP53 protein express

Animal Models:
Mouse knock-out Stam2^tm1Sug for STAM2
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Stam2):

cellular

hematopoietic system

immune system

mortality/aging

normal

STAM2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IL-2 Signaling Pathway

IL-2 Signaling Pathway

1.00

IL2-mediated signaling events

0.42

Signaling by FGFR

Signaling by EGFR

0.84

Signaling by EGFR in Cancer

0.83

Disease

Disease

1.00

Membrane Trafficking

Membrane Trafficking

1.00

Endocytosis

Endocytosis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 GeneGo (Thomson Reuters) Pathways for STAM2

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / Sorting endosome formation in CF

3 BioSystems Pathways for STAM2

	IL-7 Signaling Pathway
	IL-2 Signaling Pathway
	IL2-mediated signaling events

5/7 Reactome Pathways for STAM2 (see all 7)

	Membrane Trafficking
	Signal Transduction
	Signaling by EGFR in Cancer
	Endosomal Sorting Complex Required For Transport (ESCRT)
	Signaling by EGFR

2 Kegg Pathways (Kegg details for STAM2):

	Endocytosis
	Jak-STAT signaling pathway

STAM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STAM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for STAM2 (O75886^{1, 2, 3} ENSP00000263904⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LCP2	Q13094²^,³, ENSP00000046794⁴	MINT-4302592 MINT-4302576 MINT-4302608 I2D: score=1 STRING: ENSP00000046794
RIN1	Q13671¹^,³, ENSP00000310406⁴	EBI-373258,EBI-366017 I2D: score=1 STRING: ENSP00000310406
STAMBP	O95630¹^,²^,³, ENSP00000344742⁴	EBI-373258,EBI-396676 MINT-68431 I2D: score=6 STRING: ENSP00000344742
JAK1	P23458²^,³, ENSP00000343204⁴	MINT-49798 MINT-15831 I2D: score=4 STRING: ENSP00000343204
UBC	P0CG48²^,³, ENSP00000344818⁴	MINT-50279 I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0016044	cellular membrane organization	TAS	--
GO:0016197	endosomal transport	TAS	--
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	TAS	--

STAM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STAM2
Search CenterWatch for drugs/clinical trials and news about STAM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for STAM2 gene:

NM_005843.4

Unigene Cluster for STAM2:

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Hs.17200 [show with all ESTs]

Unigene Representative Sequence: NM_005843

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263904(uc002tyc.4 uc010foa.1 uc002tyd.3) ENST00000489389

ENST00000482997 ENST00000463854 ENST00000465460 ENST00000494589

miRNA Products:		OriGene 3'-UTR Clone: STAM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAM2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate STAM2 (see all 36):
		hsa-miR-219-1-3p hsa-miR-607 hsa-miR-218 hsa-miR-570 hsa-miR-298 hsa-miR-2113 hsa-miR-3163 hsa-miR-548e

		SwitchGear 3'UTR luciferase reporter plasmid: STAM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAM2 (see all 7) OriGene shRNA RFP: STAM2 OriGene siRNA: STAM2
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: STAM2 (NM_005843)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAM2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAM2

Additional cDNA sequence:

AF042273.1 AK023490.1 AK292265.1 AK292847.1 AK310863.1 AL133600.1 AL161997.1 BC028740.2

11 DOTS entries:

DT.310958 DT.100781149 DT.97822278 DT.91744471 DT.100781150 DT.100781151 DT.86846475 DT.91685997

DT.91744464 DT.99948248 DT.91951421

24/145 AceView cDNA sequences (see all 145):

BE468246 AI271656 BC028740 BM129542 BM129846 BU162399 AL602373 CK819737

W42638 AI342997 CA397988 CA311217 AI357027 BM974568 AA504242 AI332445

AL709155 AI858871 Z40338 AI445912 AJ709063 AA680397 AK023490 AU279676

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

STAM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

STAM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See STAM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAM2

SOURCE GeneReport for Unigene cluster: Hs.17200

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for STAM2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for STAM2 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	STAM2¹	signal transducing adaptor molecule (SH3 domain and more	79.66(n) 80.28(a)		424317 NM_001012922.1 NP_001012940.1
lizard (Anolis carolinensis)	Reptilia	STAM2⁶	--	75(a)	1 ↔ 1	GL343296.1(1349302-1363212)
African clawed frog (Xenopus laevis)	Amphibia	stam2-prov²	signal transducing adaptor molecule (SH3 domain and more	76.62(n)		BC043767.1
zebrafish (Danio rerio)	Actinopterygii	stam2¹	signal transducing adaptor molecule (SH3 domain and more	65.36(n) 67.77(a)		492497 NM_001007369.1 NP_001007370.1
fruit fly (Drosophila melanogaster)	Insecta	Stam³	regulation of JAK-STAT cascade JAK pathway signal more	43(a)		32B1 --
worm (Caenorhabditis elegans)	Secernentea	stam-1⁶	Signal transducing adapter molecule 1	26(a)	1 → many	I(5902098-5904700)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G32760⁶ AT3G08790⁶ (see all 9)	ENTH/VHS/GAT family protein (see all 9)	9(a) 9(a) (see all 9)	many ↔ many many ↔ many (see all 9)	4(15799077-15804175) 3(2667881-2671001)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	VHS and GAT domain containing protein, expressed (see all 10)	9(a) 9(a) (see all 10)	many ↔ many many ↔ many (see all 10)	11(4989236-5002099) 1(35313316-35317802)

ENSEMBL Gene Tree for STAM2 (if available)
TreeFam Gene Tree for STAM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for STAM2 gene

STAM²

2 SIMAP similar genes for STAM2 using alignment to 1 protein entry: STAM2_HUMAN:

STAM SH3GL2

STAM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60990857^1,2	C	--	152972936(+)	`TTTTT-/TGAGAT`	1	--	ds500¹		2		NA CSA	4
rs188830806^1,2		--	152973181(+)	`TGCCTC/TGGCCT`	1	--	ds500¹		0	--	--	--	--
rs148873151^1,2		--	152973222(+)	`ACCACA/GCCCGG`	1	--	ds500¹		0	--	--	--	--
rs143533240^1,2		--	152973317(+)	`ACATAC/TATTTT`	1	--	ut3¹		0	--	--	--	--
rs79298907^1,2		--	152973500(+)	`TGTATC/TCACCA`	1	--	ut3¹		0	--	--	--	--
rs140751906^1,2		--	152973576(+)	`AAATTA/TGGAGG`	1	--	ut3¹		0	--	--	--	--
rs13005388^1,2	C,F,	--	152973623(+)	`CTCTTT/CTGACA`	1	--	ut3¹		9		NA WA EA	506
rs144684480^1,2		--	152973640(+)	`GATTTA/TAAAAA`	1	--	ut3¹		0	--	--	--	--
rs138523241^1,2		--	152973862(+)	`AGAGAC/TAGGGT`	1	--	ut3¹		0	--	--	--	--
rs181465390^1,2		--	152973868(+)	`AGGGTC/TTTGCC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for STAM2 (152973315 - 153032506 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for STAM2
2 CNVs: 90079 8961

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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STAM2 for disorders           About GeneDecksing

OMIM gene information: 606244    OMIM disorders: --

2 diseases for STAM2:    About MalaCards

ataxia neuronitis

Export disorders for STAM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for STAM2 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with STAM2)

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STAM2, a new member of the STAM family, binding to the Janus kinases. (PubMed id 10899310)^{1, 2, 3} Endo K.... Sugamura K. (2000)
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)^{1, 2, 9} Bache K.G.... Stenmark H. (2003)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. (PubMed id 15882967)^{1, 2} Lechner M.S.... Rauscher F.J. III (2005)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. (PubMed id 10993906)^{1, 3} Pandey A....Lodish H.F. (2000)
Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PubMed id 15113837)^{1, 9} Mizuno E....Komada M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10254	HGNC: 11358	AceView: STAM2	Ensembl:ENSG00000115145	euGenes: HUgn10254
ECgene: STAM2	Kegg: 10254	H-InvDB: STAM2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for STAM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for STAM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for STAM2 gene:
Search GeneIP for patents involving STAM2

GeneCards and IP:
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