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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAM2 Gene

protein-coding   GIFtS: 60
GCID: GC02M152939

Signal Transducing Adaptor Molecule (SH3 Domain And ITAM...

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 21 2     STAM2B2
STAM-22 3     HSE1 Homolog2
Hrs-Binding Protein2 3     Signal Transducing Adapter Molecule 22
HSE1 Homolog (S. Cerevisiae)1     STAM-Like Protein Containing SH3 And ITAM Domains 22
Hbp2     HBP3
STAM2A2     

External Ids:    HGNC: 113581   Entrez Gene: 102542   Ensembl: ENSG000001151457   OMIM: 6062445   UniProtKB: O758863   

Export aliases for STAM2 gene to outside databases

Previous GC identifers: GC02M150726 GC02M151504 GC02M153177 GC02M152800 GC02M152683 GC02M144859


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STAM2 Gene:
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream
signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based
activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in
response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the
signaling pathway downstream of JAK kinases upon cytokine stimulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAM2 Gene: 
STAM2 (signal transducing adaptor molecule (SH3 domain and ITAM motif) 2) is a protein-coding gene. Diseases associated with STAM2 include neuronitis, and among its related super-pathways are Signaling by FGFR and Normal wtCFTR traffic / Sorting endosome formation. GO annotations related to this gene include protein binding. An important paralog of this gene is TOM1L2.

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and
GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role
in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs)
when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that
recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking
processes (By similarity)

Gene Wiki entry for STAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAM2 gene promoter:
         HFH-3   CUTL1   LCR-F1   Evi-1   E47   c-Ets-1   FOXI1   POU2F1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for STAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

STAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAM2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M152939:  view genomic region     (about GC identifiers)

Start:
152,973,315 bp from pter      End:
153,032,506 bp from pter
Size:
59,192 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886 (See protein sequence)
Recommended Name: Signal transducing adapter molecule 2  
Size: 525 amino acids; 58164 Da
Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed
of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the
deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the
interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct
Subcellular location: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein; Cytoplasmic
side
3 PDB 3D structures from and Proteopedia for STAM2:
1X2Q (3D)        1X5B (3D)        2L0T (3D)    
Secondary accessions: A8K8A0 D3DPA1 Q7LDQ0 Q9UF58
Alternative splicing: 2 isoforms:  O75886-1   O75886-2   

Explore the universe of human proteins at neXtProt for STAM2: NX_O75886

Explore proteomics data for STAM2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75886

  • STAM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    STAM2 Protein Expression
    REFSEQ proteins: NP_005834.4  
    ENSEMBL proteins: 
     ENSP00000263904  
    Reactome Protein details: O75886
    Human Recombinant Protein Products for STAM2: 
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    Novus Biologicals STAM2 Proteins
    Novus Biologicals STAM2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAM2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0031901early endosome membrane IEA--

    STAM2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR002014 VHS
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS
     IPR000108 p67phox
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry O75886

    ProtoNet protein and cluster: O75886

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB002014 VHS


    UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886
    Domain: The VHS and UIM domains mediate the interaction with ubiquitinated proteins
    Domain: The SH3 domain mediates the interaction with USP8
    Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow
    domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the
    chromoshadow domain
    Similarity: Belongs to the STAM family
    Similarity: Contains 1 ITAM domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat
    Similarity: Contains 1 VHS domain


    STAM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAM2_HUMAN, O75886
    Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and
    GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role
    in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs)
    when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that
    recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking
    processes (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    STAM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for STAM2:
     Decreased TP53 protein express 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stam2):
     cellular  hematopoietic system  immune system  mortality/aging  normal 

    STAM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Stam2tm1Sug for STAM2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for STAM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for STAM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAM2 

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    miRTarBase miRNAs that target STAM2:
    hsa-mir-218 (MIRT005005)

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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate STAM2 (see all 36):
    hsa-miR-219-1-3p hsa-miR-607 hsa-miR-218 hsa-miR-570 hsa-miR-298 hsa-miR-2113 hsa-miR-3163 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidSTAM2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for STAM2 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.84
    Signaling by EGFR in Cancer0.83
    2Normal wtCFTR traffic / Sorting endosome formation
    Delta508-CFTR traffic / Sorting endosome formation in CF0.77
    3Endosomal Sorting Complex Required For Transport (ESCRT)
    Endosomal Sorting Complex Required For Transport (ESCRT)0.71
    4Signaling by GPCR
    Signal Transduction0.55
    5IL-2 Signaling pathway
    IL2-mediated signaling events0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for STAM2
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF

    2 BioSystems Pathways for STAM2
        IL-7 Signaling Pathway
    IL2-mediated signaling events

    5/7        Reactome Pathways for STAM2 (see all 7)
        Membrane Trafficking
    Signal Transduction
    Signaling by EGFR in Cancer
    Endosomal Sorting Complex Required For Transport (ESCRT)
    Signaling by EGFR


    2         Kegg Pathways  (Kegg details for STAM2):
        Endocytosis
    Jak-STAT signaling pathway


    STAM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/72 Interacting proteins for STAM2 (O758861, 2, 3 ENSP000002639044) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-4302592 MINT-4302576 MINT-4302608 I2D: score=1 STRING: ENSP00000046794
    RIN1Q136711, 3, ENSP000003104064EBI-373258,EBI-366017 I2D: score=1 STRING: ENSP00000310406
    ENSG00000206468O152053I2D: score=1 
    ENSG00000228913O152053I2D: score=1 
    ENSG00000231968O152053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0016197endosomal transport TAS--
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway TAS--

    STAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STAM2

    Search CenterWatch for drugs/clinical trials and news about STAM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for STAM2 gene: 
    NM_005843.4  

    Unigene Cluster for STAM2:

    Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
    Hs.17200  [show with all ESTs]
    Unigene Representative Sequence: NM_005843
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263904(uc002tyc.4 uc010foa.1 uc002tyd.3) ENST00000489389
    ENST00000482997 ENST00000463854 ENST00000465460 ENST00000494589
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate STAM2 (see all 36):
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    Additional mRNA sequence: 

    AF042273.1 AK023490.1 AK292265.1 AK292847.1 AK310863.1 AL133600.1 AL161997.1 BC028740.2 

    11 DOTS entries:

    DT.310958  DT.100781149  DT.97822278  DT.91744471  DT.100781150  DT.100781151  DT.86846475  DT.91685997 
    DT.91744464  DT.99948248  DT.91951421 

    24/145 AceView cDNA sequences (see all 145):

    BU619301 BM129846 CK819737 AI332445 AA504242 AU279676 Z44409 AL602373 
    CA311217 AJ709063 AA612905 AL709155 AA807752 CA397988 BM129542 AI342997 
    AI445912 BQ029983 Z40338 AI271656 BM974558 BU162399 AK023490 CK819738 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAM2 expression in normal human tissues (normalized intensities)      STAM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STAM2 Expression
    About this image


    STAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             bronchial epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Renal Collecting Duct System
             kidney ; cells in tubules   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See STAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAM2

    SOURCE GeneReport for Unigene cluster: Hs.17200

    UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STAM2 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stam21 , 5 signal transducing adaptor molecule (SH3 domain and more1, 5 86.11(n)1
    86.81(a)1
      2 (30.41 cM)5
    563241  NM_019667.21  NP_062641.11 
     526916645 
    chicken
    (Gallus gallus)
    Aves STAM21 signal transducing adaptor molecule (SH3 domain and more 79.66(n)
    80.28(a)
      424317  NM_001012922.1  NP_001012940.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAM26
    signal transducing adaptor molecule (SH3 domain an...
    78(a)
    1 ↔ 1
    GL343296.1(1338833-1367056)
    African clawed frog
    (Xenopus laevis)
    Amphibia stam2-prov2 signal transducing adaptor molecule (SH3 domain and more 76.62(n)    BC043767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stam21 signal transducing adaptor molecule (SH3 domain and more 65.36(n)
    67.77(a)
      492497  NM_001007369.1  NP_001007370.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stam3 regulation of JAK-STAT cascade JAK
    pathway signal more
    43(a)   32B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea stam-16
    Signal transducing adapter molecule 1
    30(a)
    1 → many
    I(5902095-5904697)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSE1(YHL002W)4 Subunit of the endosomal Vps27p-Hse1p complex required more   --   8(102612-103970) 856387  NP_011861.1 


    ENSEMBL Gene Tree for STAM2 (if available)
    TreeFam Gene Tree for STAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAM2 gene
    TOM1L22  TOM1L12  TOM12  STAM2  
    2 SIMAP similar genes for STAM2 using alignment to 1 protein entry:     STAM2_HUMAN:
    STAM    SH3GL2

    STAM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1249 SNPs in STAM2 are shown (see all 1249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609908571,2
    C--152972936(+) TTTTT-/TGAGAT 1 -- ds50012Minor allele frequency- T:0.00NA CSA 4
    rs1888308061,2
    --152973181(+) TGCCTC/TGGCCT 1 -- ds50010--------
    rs1488731511,2
    C--152973222(+) ACCACA/GCCCGG 1 -- ds50010--------
    rs1435332401,2
    --152973317(+) ACATAC/TATTTT 1 -- ut310--------
    rs792989071,2
    --152973500(+) TGTATC/TCACCA 1 -- ut310--------
    rs1407519061,2
    C--152973576(+) AAATTA/TGGAGG 1 -- ut310--------
    rs130053881,2
    C,F--152973623(+) CTCTTT/CTGACA 1 -- ut319Minor allele frequency- C:0.05NA WA EA 506
    rs1446844801,2
    --152973640(+) GATTTA/TAAAAA 1 -- ut310--------
    rs1385232411,2
    --152973862(+) AGAGAC/TAGGGT 1 -- ut310--------
    rs1814653901,2
    --152973868(+) AGGGTC/TTTGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STAM2 (152973315 - 153032506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STAM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34659CNV Loss17911159
    nsv459740CNV Loss19166990
    nsv821757CNV Gain20364138
    dgv4344n71CNV Gain21882294
    nsv7331OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606244    OMIM disorders: --

    2 diseases for STAM2:    About MalaCards
    neuronitis    


    STAM2 for disorders           About GeneDecksing


    Export disorders for STAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAM2 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with STAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STAM2, a new member of the STAM family, binding to the Janus kinases. (PubMed id 10899310)1, 2, 3 Endo K.... Sugamura K. (2000)
    2. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)1, 2, 9 Bache K.G.... Stenmark H. (2003)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. (PubMed id 15882967)1, 2 Lechner M.S.... Rauscher F.J. III (2005)
    5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. (PubMed id 10993906)1, 3 Pandey A....Lodish H.F. (2000)
    10. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PubMed id 15113837)1, 9 Mizuno E....Komada M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10254 HGNC: 11358 AceView: STAM2 Ensembl:ENSG00000115145 euGenes: HUgn10254
    ECgene: STAM2 Kegg: 10254 H-InvDB: STAM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for STAM2 gene:
    Search GeneIP for patents involving STAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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