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STAM2 Gene

protein-coding   GIFtS: 60
GCID: GC02M152939

Signal Transducing Adaptor Molecule (SH3 Domain And ITAM...

  Search for STAM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 21 2     STAM2B2
STAM-22 3     HSE1 Homolog2
Hrs-Binding Protein2 3     Signal Transducing Adapter Molecule 22
HSE1 Homolog (S. Cerevisiae)1     STAM-Like Protein Containing SH3 And ITAM Domains 22
Hbp2     HBP3
STAM2A2     

External Ids:    HGNC: 113581   Entrez Gene: 102542   Ensembl: ENSG000001151457   OMIM: 6062445   UniProtKB: O758863   

Export aliases for STAM2 gene to outside databases

Previous GC identifers: GC02M150726 GC02M151504 GC02M153177 GC02M152800 GC02M152683 GC02M144859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAM2 Gene:
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream
signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based
activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in
response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the
signaling pathway downstream of JAK kinases upon cytokine stimulation. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAM2 Gene:
STAM2 (signal transducing adaptor molecule (SH3 domain and ITAM motif) 2) is a protein-coding gene. An important paralog of this gene is TOM1L2.

UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and
GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role
in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs)
when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that
recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking
processes (By similarity)

Gene Wiki entry for STAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAM2 gene promoter:
         HFH-3   CUTL1   LCR-F1   Evi-1   E47   c-Ets-1   FOXI1   POU2F1   POU2F1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAM2 promoter sequence
   Search Chromatin IP Primers for STAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

STAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAM2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M152939:  view genomic region     (about GC identifiers)

Start:
152,973,315 bp from pter      End:
153,032,506 bp from pter
Size:
59,192 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886 (See protein sequence)
Recommended Name: Signal transducing adapter molecule 2  
Size: 525 amino acids; 58164 Da
Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed
of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the
deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the
interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct
3 PDB 3D structures from and Proteopedia for STAM2:
1X2Q (3D)        1X5B (3D)        2L0T (3D)    
Secondary accessions: A8K8A0 D3DPA1 Q7LDQ0 Q9UF58
Alternative splicing: 2 isoforms:  O75886-1   O75886-2   

Explore the universe of human proteins at neXtProt for STAM2: NX_O75886

Explore proteomics data for STAM2 at MOPED

Post-translational modifications: 

  • Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF1
  • Ubiquitination2 at Lys134, Lys189, Lys202, Lys363
  • Modification sites at PhosphoSitePlus

  • See STAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005834.4  
    ENSEMBL proteins: 
     ENSP00000263904  
    Reactome Protein details: O75886

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002014 VHS
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS
     IPR001452 SH3_domain
     IPR003903 Ubiquitin-int_motif

    Graphical View of Domain Structure for InterPro Entry O75886

    ProtoNet protein and cluster: O75886

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB002014 VHS


    UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886
    Domain: The VHS and UIM domains mediate the interaction with ubiquitinated proteins
    Domain: The SH3 domain mediates the interaction with USP8
    Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow
    domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the
    chromoshadow domain
    Similarity: Belongs to the STAM family
    Similarity: Contains 1 ITAM domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat
    Similarity: Contains 1 VHS domain


    Find genes that share domains with STAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAM2_HUMAN, O75886
    Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and
    GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role
    in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs)
    when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that
    recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking
    processes (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with STAM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAM2:
     Decreased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stam2):
     hematopoietic system  immune system  mortality/aging  normal 

    Find genes that share phenotypes with STAM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stam2tm1Sug for STAM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAM2
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    Block miRNA regulation of human, mouse, rat STAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAM2 (see all 36):
    hsa-miR-219-1-3p hsa-miR-607 hsa-miR-218 hsa-miR-570 hsa-miR-298 hsa-miR-2113 hsa-miR-3163 hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidSTAM2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STAM2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAM2_HUMAN, O75886: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein; Cytoplasmic
    side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    nucleus4
    golgi apparatus1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with STAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAM2 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.83
    Signaling by EGFR in Cancer0.82
    2Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Signaling by GPCR
    Signal Transduction0.58
    4IL2-mediated signaling events
    IL2-mediated signaling events0.49
    5IL-9 Signaling Pathways
    IL-7 Signaling Pathway0.40


    Find genes that share SuperPaths with STAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for STAM2
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF

    2 BioSystems Pathways for STAM2
        IL-7 Signaling Pathway
    IL2-mediated signaling events

    2 Reactome Pathways for STAM2
        Endosomal Sorting Complex Required For Transport (ESCRT)
    EGFR downregulation


    2 Kegg Pathways  (Kegg details for STAM2):
        Endocytosis
    Jak-STAT signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STAM2
    Interactions:

        GeneGlobe Interaction Network for STAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAM2 (O758861, 2, 3 ENSP000002639044) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130941, 2, 3, ENSP000000467944EBI-373258,EBI-346946 MINT-4302592 MINT-4302576 MINT-4302608 I2D: score=1 STRING: ENSP00000046794
    RIN1Q136711, 3, ENSP000003104064EBI-373258,EBI-366017 I2D: score=1 STRING: ENSP00000310406
    ENSG00000206468O152053, ENSP000003730394I2D: score=1 STRING: ENSP00000373039
    ENSG00000228913O152053, ENSP000004104164I2D: score=1 STRING: ENSP00000410416
    ENSG00000231968O152053, ENSP000003961524I2D: score=1 STRING: ENSP00000396152
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0016197endosomal transport TAS--
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway TAS--
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with STAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAM2 gene: 
    NM_005843.4  

    Unigene Cluster for STAM2:

    Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
    Hs.17200  [show with all ESTs]
    Unigene Representative Sequence: NM_005843
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263904(uc002tyc.4 uc010foa.1 uc002tyd.3) ENST00000489389
    ENST00000482997 ENST00000463854 ENST00000465460 ENST00000494589
    miRNA
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    hsa-miR-219-1-3p hsa-miR-607 hsa-miR-218 hsa-miR-570 hsa-miR-298 hsa-miR-2113 hsa-miR-3163 hsa-miR-548e
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    Additional mRNA sequence: 

    AF042273.1 AK023490.1 AK292265.1 AK292847.1 AK310863.1 AL133600.1 AL161997.1 BC028740.2 

    11 DOTS entries:

    DT.310958  DT.100781149  DT.97822278  DT.91744471  DT.100781150  DT.100781151  DT.86846475  DT.91685997 
    DT.91744464  DT.99948248  DT.91951421 

    Selected AceView cDNA sequences (see all 145):

    AA807752 AA612905 BQ029983 AJ709063 BM129846 AI445912 W42638 BC028740 
    AL602373 BE468246 AL709155 CA397988 AA504242 BU162399 BM974568 AI342997 
    AI271656 Z44409 BU619301 AI357027 BM129542 AU279676 AA680397 CK819738 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    STAM2 Expression
    About this image


    STAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    STAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17200

    UniProtKB/Swiss-Prot: STAM2_HUMAN, O75886
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STAM2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stam21 , 5 signal transducing adaptor molecule (SH3 domain and more1, 5 86.11(n)1
    86.81(a)1
      2 (30.41 cM)5
    563241  NM_019667.21  NP_062641.11 
     526916645 
    chicken
    (Gallus gallus)
    Aves STAM21 signal transducing adaptor molecule (SH3 domain and more 79.66(n)
    80.28(a)
      424317  NM_001012922.1  NP_001012940.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAM26
    signal transducing adaptor molecule (SH3 domain an...
    79(a)
    1 ↔ 1
    GL343296.1(1338833-1367056)
    African clawed frog
    (Xenopus laevis)
    Amphibia stam2-prov2 signal transducing adaptor molecule (SH3 domain and more 76.62(n)    BC043767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stam26
    signal transducing adaptor molecule (SH3 domain an...
    62(a)
    1 ↔ 1
    9(39095646-39117456) ENSDARG00000005318
    fruit fly
    (Drosophila melanogaster)
    Insecta Stam1 , 3 regulation of JAK-STAT cascade JAK
    pathway signal more3
    Signal transducing adaptor molecule1
    43(a)3
    53.65(n)1
    49.86(a)1
      32B13
    345051  NM_058100.41  NP_477448.11 
    worm
    (Caenorhabditis elegans)
    Secernentea stam-16
    Protein STAM-1, isoform a
    32(a)
    many ↔ many
    I(5902095-5904689) WBGene00004109
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSE1(YHL002W)4 Subunit of the endosomal Vps27p-Hse1p complex required more   --   8(102612-103970) 856387  NP_011861.1 


    ENSEMBL Gene Tree for STAM2 (if available)
    TreeFam Gene Tree for STAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAM2 gene
    TOM1L22  TOM1L12  TOM12  STAM2  
    2 SIMAP similar genes for STAM2 using alignment to 1 protein entry:     STAM2_HUMAN:
    STAM    SH3GL2

    Find genes that share paralogs with STAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAM2 (see all 1249)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609908571,2
    C--152972936(+) TTTTT-/TGAGAT 1 -- ds50012Minor allele frequency- T:0.00NA CSA 4
    rs1888308061,2
    --152973181(+) TGCCTC/TGGCCT 1 -- ds50010--------
    rs1488731511,2
    C--152973222(+) ACCACA/GCCCGG 1 -- ds50010--------
    rs1435332401,2
    --152973317(+) ACATAC/TATTTT 1 -- ut310--------
    rs792989071,2
    --152973500(+) TGTATC/TCACCA 1 -- ut310--------
    rs1407519061,2
    C--152973576(+) AAATTA/TGGAGG 1 -- ut310--------
    rs130053881,2
    C,F--152973623(+) CTCTTT/CTGACA 1 -- ut319Minor allele frequency- C:0.05NA WA EA 506
    rs1446844801,2
    --152973640(+) GATTTA/TAAAAA 1 -- ut310--------
    rs1385232411,2
    --152973862(+) AGAGAC/TAGGGT 1 -- ut310--------
    rs1814653901,2
    --152973868(+) AGGGTC/TTTGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for STAM2 (152973315 - 153032506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for STAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34659CNV Loss17911159
    nsv459740CNV Loss19166990
    nsv821757CNV Gain20364138
    dgv4344n71CNV Gain21882294
    nsv7331OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for STAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606244    OMIM disorders: --


    Find genes that share disorders with STAM2           About GenesLikeMe


    Export disorders for STAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAM2 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with STAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. STAM2, a new member of the STAM family, binding to the Janus kinases. (PubMed id 10899310)1, 2, 3 Endo K.... Sugamura K. (FEBS Lett. 2000)
    2. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)1, 2, 9 Bache K.G.... Stenmark H. (J. Biol. Chem. 2003)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. (PubMed id 15882967)1, 2 Lechner M.S.... Rauscher F.J. III (Biochem. Biophys. Res. Commun. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. (PubMed id 10993906)1, 3 Pandey A....Lodish H.F. (J. Biol. Chem. 2000)
    10. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PubMed id 15113837)1, 9 Mizuno E....Komada M. (J. Biochem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10254 HGNC: 11358 AceView: STAM2 Ensembl:ENSG00000115145 euGenes: HUgn10254
    ECgene: STAM2 Kegg: 10254 H-InvDB: STAM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAM2 gene:
    Search GeneIP for patents involving STAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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