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Aliases for STAM2 Gene

Aliases for STAM2 Gene

  • Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 2 2 3
  • Hrs-Binding Protein 3 4
  • STAM-2 3 4
  • HBP 3 4
  • STAM-Like Protein Containing SH3 And ITAM Domains 2 3
  • HSE1 Homolog (S. Cerevisiae) 2
  • HSE1 Homolog 3
  • STAM2A 3
  • STAM2B 3

External Ids for STAM2 Gene

Previous GeneCards Identifiers for STAM2 Gene

  • GC02M150726
  • GC02M151504
  • GC02M152939
  • GC02M153177
  • GC02M152800
  • GC02M152683
  • GC02M144859

Summaries for STAM2 Gene

Entrez Gene Summary for STAM2 Gene

  • The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAM2 Gene

STAM2 (Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. An important paralog of this gene is TOM1L1.

UniProtKB/Swiss-Prot for STAM2 Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Gene Wiki entry for STAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAM2 Gene

Genomics for STAM2 Gene

Regulatory Elements for STAM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for STAM2 Gene

Chromosome:
2
Start:
152,116,801 bp from pter
End:
152,175,992 bp from pter
Size:
59,192 bases
Orientation:
Minus strand

Genomic View for STAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAM2 Gene

Proteins for STAM2 Gene

  • Protein details for STAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75886-STAM2_HUMAN
    Recommended name:
    Signal transducing adapter molecule 2
    Protein Accession:
    O75886
    Secondary Accessions:
    • A8K8A0
    • D3DPA1
    • Q7LDQ0
    • Q9UF58

    Protein attributes for STAM2 Gene

    Size:
    525 amino acids
    Molecular mass:
    58164 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity).

    Three dimensional structures from OCA and Proteopedia for STAM2 Gene

    Alternative splice isoforms for STAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAM2 Gene

Proteomics data for STAM2 Gene at MOPED

Post-translational modifications for STAM2 Gene

  • Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF
  • Ubiquitination at Lys 134, Lys 189, Lys 202, and Lys 363
  • Modification sites at PhosphoSitePlus

Other Protein References for STAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STAM2 (STAM2)

No data available for DME Specific Peptides for STAM2 Gene

Domains & Families for STAM2 Gene

Gene Families for STAM2 Gene

HGNC:

Protein Domains for STAM2 Gene

Suggested Antigen Peptide Sequences for STAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75886

UniProtKB/Swiss-Prot:

STAM2_HUMAN :
  • The VHS and UIM domains mediate the interaction with ubiquitinated proteins
  • Belongs to the STAM family.
Domain:
  • The VHS and UIM domains mediate the interaction with ubiquitinated proteins
  • The SH3 domain mediates the interaction with USP8
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain
  • Contains 1 ITAM domain.
  • Contains 1 SH3 domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the STAM family.
genes like me logo Genes that share domains with STAM2: view

Function for STAM2 Gene

Molecular function for STAM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Gene Ontology (GO) - Molecular Function for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with STAM2: view
genes like me logo Genes that share phenotypes with STAM2: view

Animal Models for STAM2 Gene

MGI Knock Outs for STAM2:

Animal Model Products

miRNA for STAM2 Gene

miRTarBase miRNAs that target STAM2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for STAM2 Gene

Localization for STAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAM2 Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAM2 Gene COMPARTMENTS Subcellular localization image for STAM2 gene
Compartment Confidence
cytosol 4
nucleus 4
endosome 3
lysosome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0031901 early endosome membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with STAM2: view

Pathways & Interactions for STAM2 Gene

genes like me logo Genes that share pathways with STAM2: view

Pathways by source for STAM2 Gene

Gene Ontology (GO) - Biological Process for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0016197 endosomal transport TAS --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with STAM2: view

No data available for SIGNOR curated interactions for STAM2 Gene

Drugs & Compounds for STAM2 Gene

No Compound Related Data Available

Transcripts for STAM2 Gene

Unigene Clusters for STAM2 Gene

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAM2 Gene

No ASD Table

Relevant External Links for STAM2 Gene

GeneLoc Exon Structure for
STAM2
ECgene alternative splicing isoforms for
STAM2

Expression for STAM2 Gene

mRNA expression in normal human tissues for STAM2 Gene

Protein differential expression in normal tissues from HIPED for STAM2 Gene

This gene is overexpressed in Bone marrow stromal cell (9.3) and Fetal Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAM2 Gene



SOURCE GeneReport for Unigene cluster for STAM2 Gene Hs.17200

mRNA Expression by UniProt/SwissProt for STAM2 Gene

O75886-STAM2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with STAM2: view

Protein tissue co-expression partners for STAM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STAM2 Gene

Orthologs for STAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia STAM2 35
  • 93.03 (n)
  • 94.53 (a)
STAM2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAM2 35
  • 92.9 (n)
  • 94.34 (a)
STAM2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stam2 35
  • 86.11 (n)
  • 86.81 (a)
Stam2 16
Stam2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAM2 35
  • 99.81 (n)
  • 99.62 (a)
STAM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stam2 35
  • 84.45 (n)
  • 84.89 (a)
oppossum
(Monodelphis domestica)
Mammalia STAM2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves STAM2 35
  • 79.66 (n)
  • 80.28 (a)
STAM2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAM2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stam2 35
  • 70.14 (n)
  • 71.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia stam2-prov 35
zebrafish
(Danio rerio)
Actinopterygii stam2 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stam 37
  • 43 (a)
Stam 35
  • 53.65 (n)
  • 49.86 (a)
Stam 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea stam-1 36
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 36
  • 24 (a)
OneToMany
HSE1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1021 36
  • 38 (a)
OneToMany
Species with no ortholog for STAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAM2 Gene

ENSEMBL:
Gene Tree for STAM2 (if available)
TreeFam:
Gene Tree for STAM2 (if available)

Paralogs for STAM2 Gene

Paralogs for STAM2 Gene

(2) SIMAP similar genes for STAM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STAM2: view

Variants for STAM2 Gene

Sequence variations from dbSNP and Humsavar for STAM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1133478 -- 152,117,740(-) TTTTT(A/T)AAAAA utr-variant-3-prime, nc-transcript-variant
rs1137674 -- 152,120,020(+) GCAAG(C/G/T)TAAAT utr-variant-3-prime, nc-transcript-variant
rs2002247 -- 152,169,064(+) AGCCC(C/T)GAAGC intron-variant
rs2345640 -- 152,169,337(-) attgc(A/G)tcact intron-variant
rs2345641 -- 152,169,151(-) TTCTG(C/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAM2 Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
dgv4344n71 CNV Gain 21882294
nsv7331 OTHER Inversion 18451855
nsv459740 CNV Loss 19166990
nsv821757 CNV Gain 20364138

Variation tolerance for STAM2 Gene

Residual Variation Intolerance Score: 21.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 45.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAM2 Gene

HapMap Linkage Disequilibrium report
STAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAM2 Gene

Disorders for STAM2 Gene

Relevant External Links for STAM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAM2
genes like me logo Genes that share disorders with STAM2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAM2 Gene

Publications for STAM2 Gene

  1. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PMID: 15113837) Mizuno E. … Komada M. (J. Biochem. 2004) 23 67
  2. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache K.G. … Stenmark H. (J. Biol. Chem. 2003) 23 67
  3. STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. (PMID: 12972556) Mizuno E. … Komada M. (Mol. Biol. Cell 2003) 23 67
  4. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. (PMID: 10993906) Pandey A. … Lodish H.F. (J. Biol. Chem. 2000) 2 67
  5. STAM2, a new member of the STAM family, binding to the Janus kinases. (PMID: 10899310) Endo K. … Sugamura K. (FEBS Lett. 2000) 2 67

Products for STAM2 Gene

Sources for STAM2 Gene

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