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Aliases for STAM2 Gene

Aliases for STAM2 Gene

  • Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 2 2 3
  • Hrs-Binding Protein 3 4
  • STAM-2 3 4
  • HBP 3 4
  • STAM-Like Protein Containing SH3 And ITAM Domains 2 3
  • Signal Transducing Adapter Molecule 2 3
  • HSE1 Homolog (S. Cerevisiae) 2
  • HSE1 Homolog 3
  • STAM2A 3
  • STAM2B 3

External Ids for STAM2 Gene

Summaries for STAM2 Gene

Entrez Gene Summary for STAM2 Gene

  • The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAM2 Gene

STAM2 (Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. An important paralog of this gene is TOM1L1.

UniProtKB/Swiss-Prot for STAM2 Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Gene Wiki entry for STAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAM2 Gene

Genomics for STAM2 Gene

Genomic Location for STAM2 Gene

Start:
152,116,801 bp from pter
End:
152,175,992 bp from pter
Size:
59,192 bases
Orientation:
Minus strand

Genomic View for STAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAM2 Gene

Regulatory Elements for STAM2 Gene

Proteins for STAM2 Gene

  • Protein details for STAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75886-STAM2_HUMAN
    Recommended name:
    Signal transducing adapter molecule 2
    Protein Accession:
    O75886
    Secondary Accessions:
    • A8K8A0
    • D3DPA1
    • Q7LDQ0
    • Q9UF58

    Protein attributes for STAM2 Gene

    Size:
    525 amino acids
    Molecular mass:
    58164 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct.

    Three dimensional structures from OCA and Proteopedia for STAM2 Gene

    Alternative splice isoforms for STAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAM2 Gene

Proteomics data for STAM2 Gene at MOPED

Post-translational modifications for STAM2 Gene

  • Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys134, Lys189, Lys202, and Lys363

Other Protein References for STAM2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for STAM2 Gene

Domains for STAM2 Gene

Protein Domains for STAM2 Gene

UniProtKB/Swiss-Prot:

STAM2_HUMAN
Domain:
  • The VHS and UIM domains mediate the interaction with ubiquitinated proteins:
    • O75886
  • The SH3 domain mediates the interaction with USP8:
    • O75886
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain:
    • O75886
  • Contains 1 ITAM domain.:
    • O75886
  • Contains 1 SH3 domain.:
    • O75886
  • Contains 1 UIM (ubiquitin-interacting motif) domain.:
    • O75886
  • Contains 1 VHS domain.:
    • O75886
Family:
  • Belongs to the STAM family.:
    • O75886
genes like me logo Genes that share domains with STAM2: view

No data available for Gene Families for STAM2 Gene

Function for STAM2 Gene

Molecular function for STAM2 Gene

UniProtKB/Swiss-Prot Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Gene Ontology (GO) - Molecular Function for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with STAM2: view
genes like me logo Genes that share phenotypes with STAM2: view

Animal Models for STAM2 Gene

MGI Knock Outs for STAM2:

miRNA for STAM2 Gene

miRTarBase miRNAs that target STAM2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STAM2 Gene

Localization for STAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAM2 Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAM2 Gene COMPARTMENTS Subcellular localization image for STAM2 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 4
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAM2: view

Pathways for STAM2 Gene

genes like me logo Genes that share pathways with STAM2: view

Pathways by source for STAM2 Gene

Gene Ontology (GO) - Biological Process for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0016197 endosomal transport TAS --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with STAM2: view

Transcripts for STAM2 Gene

Unigene Clusters for STAM2 Gene

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAM2 Gene

No ASD Table

Relevant External Links for STAM2 Gene

GeneLoc Exon Structure for
STAM2
ECgene alternative splicing isoforms for
STAM2

Expression for STAM2 Gene

mRNA expression in normal human tissues for STAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAM2 Gene

SOURCE GeneReport for Unigene cluster for STAM2 Gene Hs.17200

mRNA Expression by UniProt/SwissProt for STAM2 Gene

O75886-STAM2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with STAM2: view

Orthologs for STAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAM2 36
  • 99.81 (n)
  • 99.62 (a)
STAM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAM2 36
  • 93.03 (n)
  • 94.53 (a)
STAM2 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAM2 36
  • 92.9 (n)
  • 94.34 (a)
STAM2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stam2 36
  • 86.11 (n)
  • 86.81 (a)
Stam2 16
Stam2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAM2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Stam2 36
  • 84.45 (n)
  • 84.89 (a)
chicken
(Gallus gallus)
Aves STAM2 36
  • 79.66 (n)
  • 80.28 (a)
STAM2 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAM2 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia stam2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia stam2 36
  • 70.14 (n)
  • 71.04 (a)
zebrafish
(Danio rerio)
Actinopterygii stam2 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stam 36
  • 53.65 (n)
  • 49.86 (a)
Stam 37
  • 32 (a)
OneToMany
Stam 38
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea stam-1 37
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 37
  • 24 (a)
OneToMany
HSE1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1021 37
  • 38 (a)
OneToMany
Species with no ortholog for STAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAM2 Gene

ENSEMBL:
Gene Tree for STAM2 (if available)
TreeFam:
Gene Tree for STAM2 (if available)

Paralogs for STAM2 Gene

Paralogs for STAM2 Gene

Selected SIMAP similar genes for STAM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STAM2: view

Variants for STAM2 Gene

Sequence variations from dbSNP and Humsavar for STAM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1133478 -- 152,117,740(-) TTTTT(A/T)AAAAA utr-variant-3-prime
rs1137674 -- 152,120,020(+) GCAAG(C/G/T)TAAAT utr-variant-3-prime
rs2002247 -- 152,169,064(+) AGCCC(C/T)GAAGC intron-variant
rs2345639 -- 152,174,599(-) GCAGT(A/G)ATTCC intron-variant
rs2345640 -- 152,169,337(-) attgc(A/G)tcact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAM2 Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
dgv4344n71 CNV Gain 21882294
nsv7331 OTHER Inversion 18451855
nsv459740 CNV Loss 19166990
nsv821757 CNV Gain 20364138

Relevant External Links for STAM2 Gene

HapMap Linkage Disequilibrium report
STAM2

Disorders for STAM2 Gene

No disorders were found for STAM2 Gene.

No data available for UniProtKB/Swiss-Prot for STAM2 Gene

Publications for STAM2 Gene

  1. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache K.G. … Stenmark H. (J. Biol. Chem. 2003) 3 4 23
  2. STAM2, a new member of the STAM family, binding to the Janus kinases. (PMID: 10899310) Endo K. … Sugamura K. (FEBS Lett. 2000) 2 3 4
  3. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. (PMID: 10993906) Pandey A. … Lodish H.F. (J. Biol. Chem. 2000) 2 3
  4. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PMID: 15113837) Mizuno E. … Komada M. (J. Biochem. 2004) 3 23
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for STAM2 Gene

Sources for STAM2 Gene

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