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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

STAM Gene

protein-coding   GIFtS: 62
GCID: GC10P017686

signal transducing adaptor molecule (SH3 domain and ITAM...
 Explore 4 diseases affiliated with
STAM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for STAM    

Aliases
for STAM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 11 2
STAM11 2 3
STAM-12 3
HSE1 Homolog2
Signal Transducing Adapter Molecule 12

External Ids:    HGNC: 113571   Entrez Gene: 80272   Ensembl: ENSG000001367387   OMIM: 6018995   UniProtKB: Q927833   
ORGUL members:         
NONCODE:n410556    

Export aliases for STAM gene to outside databases

Previous GC identifers: GC10P017668 GC10P017836 GC10P017690 GC10P017726 GC10P017598


Summaries
for STAM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for STAM:
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream
signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein
II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the
endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the
ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.
(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL
stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell
development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed
with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes
ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes

Gene Wiki entry for STAM (Signal transducing adaptor molecule)


Genomic Views
for STAM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STAM gene promoter:
         GR   RP58   Lmo2   CREB   MEF-2A   Pax-3   Ik-2   deltaCREB   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: STAM promoter sequence
   Search SABiosciences Chromatin IP Primers for STAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14-p13   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p14-p13

STAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAM gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P017686:  view genomic region     (about GC identifiers)

Start:
 17,686,124 bp from pter      End:
 17,757,913 bp from pter
Size:
 71,790 bases      Orientation:
 plus strand

1 alternative location:
Chr10+,PATCHES 17,809,589-17,881,372     

Proteins
for STAM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783 (See protein sequence)
Recommended Name: Signal transducing adapter molecule 1  
Size: 540 amino acids; 59180 Da
Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least
composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB
Subcellular location: Cytoplasm (Probable). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
(Probable)
3 PDB 3D structures from and Proteopedia for STAM:
2L0A (3D)        3F1I (3D)        3LDZ (3D)    
Secondary accessions: B0YJ99 D3DRU5 Q8N6D9
Alternative splicing: 2 isoforms:  Q92783-1   Q92783-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAM: NX_Q92783

Post-translational modifications:

  • Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated
    • by activated PDGFRB1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92783

    • STAM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003464.1  
    ENSEMBL proteins: 
     ENSP00000366746   ENSP00000400025   ENSP00000366721   ENSP00000438073  
    Reactome Protein details: Q92783
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for STAM (STAM-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: STAM
    OriGene Protein Over-expression Lysate: STAM
    OriGene Custom Protein Services for STAM 
    GenScript Custom Purified and Recombinant Proteins Services for STAM
    Novus Biologicals STAM Protein
    Novus Biologicals STAM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for STAM

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0031901early endosome membrane IEA--


    STAM for ontologies           About GeneDecksing



    STAM Antibody Products: 
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    Abcam antibodies for STAM 
    Uscn Antibodies for STAM
    ThermoFisher Antibody for STAM

    Assay Products for STAM: 
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    Uscn ELISAs and CLIAs for STAM

    Protein Domains /
    Families
    for STAM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    STAM for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR002014 VHS
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS
     IPR000108 p67phox
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q92783

    ProtoNet protein and cluster: Q92783

    3 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB002014 VHS
    IPB003110 Phosphorylated immunoreceptor signaling ITAM


    UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
    Domain: The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos
    Similarity: Belongs to the STAM family
    Similarity: Contains 1 ITAM domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat
    Similarity: Contains 1 VHS domain


    Function
    for STAM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
    Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL
    stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell
    development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed
    with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes
    ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes

         Genatlas biochemistry entry for STAM:
    signal-transducin adaptor molecule involved in cytokine-mediated signal transduction

    miRNA
    Products:            		 OriGene 3'-UTR Clone: STAM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAM
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate STAM (see all 30):
    hsa-miR-142-3p hsa-miR-562 hsa-miR-548v hsa-miR-488 hsa-miR-197 hsa-miR-9 hsa-miR-144 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: STAM 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAM (see all 7)
    OriGene shRNA RFP: STAM
    OriGene siRNA: STAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAM

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for STAM

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAM (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAM
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STAM (NM_003473)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAM 

    Cell Line
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    Search LifeMap BioReagents cell lines for STAM

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAM

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8780729
    GO:0005515protein binding IPI10383417


    STAM for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for STAM:
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-out Stamtm1Sug for STAM
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Stam):
     behavior/neurological  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  nervous system  reproductive system 

    STAM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for STAM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IL-2 Signaling Pathway
    		IL-2 Signaling Pathway1.00
    		IL2-mediated signaling events0.42
    2Signaling by FGFR
    		Signaling by EGFR0.84
    		Signaling by EGFR in Cancer0.83
    3Disease
    		Disease1.00
    4Membrane Trafficking
    		Membrane Trafficking1.00
    5IL-4 signaling Pathway
    		IL-4 signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for STAM
        JAK-STAT Pathway

    4 BioSystems Pathways for STAM 
        IL-7 Signaling Pathway
    IL-2 Signaling Pathway
    IL-4 signaling Pathway
    IL2-mediated signaling events

    5/7        Reactome Pathways for STAM (see all 7)
        Membrane Trafficking
    Signal Transduction
    Signaling by EGFR in Cancer
    Endosomal Sorting Complex Required For Transport (ESCRT)
    Signaling by EGFR


    2         Kegg Pathways  (Kegg details for STAM):
        Endocytosis
    Jak-STAT signaling pathway


    STAM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for STAM (Q927831, 2, 3 ENSP000003667464) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-4302459 MINT-4302560 MINT-4302518 I2D: score=1 STRING: ENSP00000046794
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145828 I2D: score=1 STRING: ENSP00000350297
    MED28Q9H2042, 3, ENSP000002373804MINT-7041809 I2D: score=1 STRING: ENSP00000237380
    PPP1CAP621362, 3MINT-62195 I2D: score=3 
    UBCP0CG482, 3, ENSP000003448184MINT-50276 MINT-50275 MINT-50282 MINT-7896409 MINT-50277 MINT-6804185 I2D: score=3 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction TAS8780729
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0016044cellular membrane organization TAS--
    GO:0016197endosomal transport TAS--


    STAM for ontologies           About GeneDecksing



    Drugs & Compounds
    for STAM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    STAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STAM
    2 Novoseek chemical compound relationships for STAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 98.5 100 9133424 (7), 15113837 (7), 10231582 (6), 12972556 (5) (see all 30)
    tyrosine 35.8 7 9133424 (2), 10383417 (1), 10329004 (1), 9407053 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about STAM / STAM1 

    Transcripts
    for STAM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for STAM gene: 
    NM_003473.3  

    Unigene Cluster for STAM:

    Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
    Hs.335391  [show with all ESTs]
    Unigene Representative Sequence: NM_003473
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377524(uc001ipj.2 uc010qcf.2 uc009xjw.2) ENST00000445846
    ENST00000377500 ENST00000475749 ENST00000486183 ENST00000494250 ENST00000540523


    miRNA
    Products:             		 OriGene 3'-UTR Clone: STAM
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat STAM
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate STAM (see all 30):
    hsa-miR-142-3p hsa-miR-562 hsa-miR-548v hsa-miR-488 hsa-miR-197 hsa-miR-9 hsa-miR-144 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: STAM 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAM (see all 7)
    OriGene shRNA RFP: STAM
    OriGene siRNA: STAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAM
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAM
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: STAM (NM_003473)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAM 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAM

    Additional cDNA sequence: 

    AK303083.1 AK314405.1 BX647982.1 NR_037774.1 U43899.1 

    13 DOTS entries:

    DT.417407  DT.100789063  DT.95069537  DT.91971542  DT.40117266  DT.417402  DT.97786408  DT.100027100 
    DT.95069528  DT.100769058  DT.121619797  DT.40267905  DT.92433048 

    24/146 AceView cDNA sequences (see all 146):

    AA411005 AL695091 BC030586 CB146993 BQ023148 AA970559 BU150378 NM_003473 
    CA415361 AA045382 BP363068 AL597599 AW862561 AW606994 BM683143 BP354835 
    N77835 BU163838 BM453429 AW196913 BM453710 BM922271 AL598610 BP350557 

    GeneLoc Exon Structure


    Expression
    for STAM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    STAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACAAAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See STAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for STAM

    SOURCE GeneReport for Unigene cluster: Hs.335391

    UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including STAM: 
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAM
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAM

    Orthologs
    for STAM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STAM gene from 10/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Stam1 , 5 signal transducing adaptor molecule (SH3 domain and more1, 5 88.7(n)1
    92.41(a)1    		   2 (10.36 cM)5
    208441  NM_011484.21  NP_035614.11 
     140741005 
    chicken
    (Gallus gallus)    		 Aves STAM1 signal transducing adaptor molecule (SH3 domain and more 81.55(n)
    88.74(a)    		   420517  XM_418619.3  XP_418619.3 
    lizard
    (Anolis carolinensis)    		 Reptilia STAM6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 6(18126805-18144038)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC762312 hypothetical protein MGC76231 77.24(n)    BC063925.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufv75b102 wufv75b10 78.13(n)   386967  BC045442.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Stam1 , 3 regulation of JAK-STAT cascade JAK pathway
    signal more3
    Signal transducing adaptor molecule1    		 45(a)3
    50.1(n)1
    43.86(a)1    		   32B13
    345051  NM_058100.31  NP_477448.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea stam-11 Protein STAM-1 47.77(n)
    35.25(a)    		   172264  NM_059309.5  NP_491710.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HSE11 Hse1p 43.56(n)
    28.26(a)    		   856387   NP_011861.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G062106
    AT5G168806
    (see all 9)    		 Target of Myb protein 1
    (see all 9)    		 14(a)
    14(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 1(1897203-1899208)
    5(5548914-5551463)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 10)    		 VHS and GAT domain containing protein, expressed
    (see all 10)    		 16(a)
    15(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 10(22980611-22983543)
    2(28667133-28671003)


    ENSEMBL Gene Tree for STAM (if available)
    TreeFam Gene Tree for STAM (if available) 

    Paralogs
    for STAM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for STAM gene
    STAM22  
    7 SIMAP similar genes for STAM using alignment to 4 protein entries:     STAM1_HUMAN (see all proteins):
    STAM2    SH3GL1    ARHGEF7    DLG2    SH3GL2    ITSN2
    SORBS3

    STAM for paralogs           About GeneDecksing



    Genomic Variants
    for STAM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1573 NCBI SNPs in STAM are shown (see all 1573)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1920670641,2
    		--17684198(+) AGAATA/CTTGCC 2 -- us2k10--------
    rs727807901,2
    		C,--17684237(+) TCATGT/CATTTC 2 -- us2k12Minor allele frequency- C:0.28NA 122
    rs22515961,2
    		C,F,O,A,H,--17684398(+) TTTAAT/CTGACC 2 -- us2k1 tfbs328Minor allele frequency- C:0.36NA NS EA WA CSA 2493
    rs115918041,2
    		C,H,--17684577(+) ACTCAA/C/GTGTGG 2 -- us2k13NA WA 122
    rs1402970881,2
    		--17684640(+) ACCTTG/TGTTCA 2 -- us2k10--------
    rs800394281,2
    		C,--17684696(+) GCTGGG/ATCCTA 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1842879571,2
    		--17684713(+) TAAAAA/TTTTTT 2 -- us2k10--------
    rs1885354751,2
    		--17684783(+) AGTATG/TTGAGT 2 -- us2k10--------
    rs618422621,2
    		--17684871(+) ATTCCG/CAGCCT 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs2001228751,2
    		--17684903(+) TACAA-/CCGCGCG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for STAM (17686124 - 17757913 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for STAM
         1 Indel: 100879

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAM
    DNA2.0 Custom Variant and Variant Library Synthesis for STAM

    Disorders / Diseases
    for STAM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    STAM for disorders           About GeneDecksing

    OMIM gene information: 601899    OMIM disorders: --

    4 diseases for STAM:    About MalaCards
    myasthenia gravis    myasthenia    alzheimer's disease    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: STAM (6 documents)

    Export disorders for STAM gene to outside databases

    Publications
    for STAM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for STAM gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with STAM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PubMed id 8780729)1, 2, 3 Takeshita T.... Sugamura K. (1996)
    2. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PubMed id 9407053)1, 2, 9 Asao H.... Sugamura K. (1997)
    3. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)1, 2, 9 Bache K.G.... Stenmark H. (2003)
    4. Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines. (PubMed id 10383417)1, 2, 9 Tanaka N.... Sugamura K. (1999)
    5. VHS domains of ESCRT-0 cooperate in high-avidity bind ing to polyubiquitinated cargo. (PubMed id 20150893)1, 2 Ren X. and Hurley J.H. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. (PubMed id 11687594)1, 2 Steen H.... Mann M. (2002)
    9. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PubMed id 15113837)1, 9 Mizuno E....Komada M. (2004)
    10. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. (PubMed id 9133424)1, 9 Takeshita T....Sugamura K. (1997)

    External Searches for STAM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing STAM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8027 HGNC: 11357 AceView: STAM Ensembl:ENSG00000136738 euGenes: HUgn8027
    ECgene: STAM Kegg: 8027 H-InvDB: STAM

    Other Databases showing STAM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing STAM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for STAM Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for STAM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for STAM gene:
    Search GeneIP for patents involving STAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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