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Aliases for STAM Gene

Aliases for STAM Gene

  • Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 1 2 3
  • STAM-1 3 4
  • STAM1 3 4
  • Signal Transducing Adapter Molecule 1 3
  • HSE1 Homolog (S. Cerevisiae) 2
  • HSE1 Homolog 3

External Ids for STAM Gene

Previous GeneCards Identifiers for STAM Gene

  • GC10P017668
  • GC10P017836
  • GC10P017690
  • GC10P017726
  • GC10P017686
  • GC10P017598

Summaries for STAM Gene

Entrez Gene Summary for STAM Gene

  • This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for STAM Gene

STAM (Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is TOM1L1.

UniProtKB/Swiss-Prot for STAM Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes

Gene Wiki entry for STAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAM Gene

Genomics for STAM Gene

Regulatory Elements for STAM Gene

Genomic Location for STAM Gene

Start:
17,644,125 bp from pter
End:
17,716,824 bp from pter
Size:
72,700 bases
Orientation:
Plus strand

Genomic View for STAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAM Gene

Proteins for STAM Gene

  • Protein details for STAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92783-STAM1_HUMAN
    Recommended name:
    Signal transducing adapter molecule 1
    Protein Accession:
    Q92783
    Secondary Accessions:
    • B0YJ99
    • D3DRU5
    • Q8N6D9

    Protein attributes for STAM Gene

    Size:
    540 amino acids
    Molecular mass:
    59180 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB.

    Three dimensional structures from OCA and Proteopedia for STAM Gene

    Alternative splice isoforms for STAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAM Gene

Proteomics data for STAM Gene at MOPED

Post-translational modifications for STAM Gene

  • Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
  • Ubiquitination at Lys99, Lys133, Lys154, Lys185, and Lys373
  • Modification sites at PhosphoSitePlus

Other Protein References for STAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for STAM Gene

Domains for STAM Gene

Suggested Antigen Peptide Sequences for STAM Gene

Graphical View of Domain Structure for InterPro Entry

Q92783

UniProtKB/Swiss-Prot:

STAM1_HUMAN :
  • Q92783
Domain:
  • The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
  • Contains 1 ITAM domain.
  • Contains 1 SH3 domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the STAM family.
genes like me logo Genes that share domains with STAM: view

No data available for Gene Families for STAM Gene

Function for STAM Gene

Molecular function for STAM Gene

GENATLAS Biochemistry: signal-transducin adaptor molecule involved in cytokine-mediated signal transduction
UniProtKB/Swiss-Prot Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes

Gene Ontology (GO) - Molecular Function for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8780729
GO:0005515 protein binding IPI 10383417
genes like me logo Genes that share ontologies with STAM: view
genes like me logo Genes that share phenotypes with STAM: view

Animal Models for STAM Gene

MGI Knock Outs for STAM:

miRNA for STAM Gene

miRTarBase miRNAs that target STAM

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for STAM Gene

Localization for STAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAM Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAM Gene COMPARTMENTS Subcellular localization image for STAM gene
Compartment Confidence
endosome 5
cytosol 4
lysosome 2
nucleus 2
vacuole 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with STAM: view

Pathways for STAM Gene

genes like me logo Genes that share pathways with STAM: view

Pathways by source for STAM Gene

Gene Ontology (GO) - Biological Process for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 8780729
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0009967 positive regulation of signal transduction TAS 8780729
GO:0016197 endosomal transport TAS --
genes like me logo Genes that share ontologies with STAM: view

Compounds for STAM Gene

(2) Novoseek inferred chemical compound relationships for STAM Gene

Compound -log(P) Hits PubMed IDs
propanil 98.5 75
tyrosine 35.8 6
genes like me logo Genes that share compounds with STAM: view

Transcripts for STAM Gene

Unigene Clusters for STAM Gene

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAM Gene

No ASD Table

Relevant External Links for STAM Gene

GeneLoc Exon Structure for
STAM
ECgene alternative splicing isoforms for
STAM

Expression for STAM Gene

mRNA expression in normal human tissues for STAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAM Gene

SOURCE GeneReport for Unigene cluster for STAM Gene Hs.335391

mRNA Expression by UniProt/SwissProt for STAM Gene

Q92783-STAM1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with STAM: view

No data available for mRNA differential expression in normal tissues for STAM Gene

Orthologs for STAM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAM 35
  • 99.51 (n)
  • 99.81 (a)
STAM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAM 35
  • 89.95 (n)
  • 93.35 (a)
STAM 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAM 35
  • 92.38 (n)
  • 95.54 (a)
STAM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stam 35
  • 88.48 (n)
  • 92.47 (a)
Stam 16
Stam 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAM 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAM 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stam 35
  • 87.45 (n)
  • 91.51 (a)
chicken
(Gallus gallus)
Aves STAM 35
  • 81.34 (n)
  • 88.05 (a)
STAM 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAM 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76231 35
stam 35
  • 73.14 (n)
  • 80.39 (a)
zebrafish
(Danio rerio)
Actinopterygii stam 35
  • 72.36 (n)
  • 81.12 (a)
stam 36
  • 76 (a)
OneToOne
wufv75b10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008494 35
  • 53.1 (n)
  • 51.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Stam 36
  • 33 (a)
OneToMany
Stam 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea stam-1 35
  • 47.82 (n)
  • 35.63 (a)
stam-1 36
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2766 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1021 36
  • 40 (a)
OneToMany
Species with no ortholog for STAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAM Gene

ENSEMBL:
Gene Tree for STAM (if available)
TreeFam:
Gene Tree for STAM (if available)

Paralogs for STAM Gene

Paralogs for STAM Gene

Selected SIMAP similar genes for STAM Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STAM: view

Variants for STAM Gene

Sequence variations from dbSNP and Humsavar for STAM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs12221 -- 17,714,597(+) GTATA(C/T)AGTCC synonymous-codon, reference, nc-transcript-variant
rs723790 -- 17,683,432(-) ATAAT(C/T)CCAGC intron-variant
rs723791 -- 17,683,367(-) CTGGG(A/C)AACAC intron-variant
rs723792 -- 17,683,307(-) GTCCC(A/G)GCTCC intron-variant
rs942775 -- 17,709,047(+) AAATA(C/T)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAM Gene

Variant ID Type Subtype PubMed ID
esv2618457 CNV Insertion 19546169
esv268267 CNV Insertion 20981092
esv269515 CNV Insertion 20981092

Relevant External Links for STAM Gene

HapMap Linkage Disequilibrium report
STAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAM Gene

Disorders for STAM Gene

Relevant External Links for STAM

Genetic Association Database (GAD)
STAM
Human Genome Epidemiology (HuGE) Navigator
STAM
genes like me logo Genes that share disorders with STAM: view

No data available for UniProtKB/Swiss-Prot for STAM Gene

Publications for STAM Gene

  1. Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines. (PMID: 10383417) Tanaka N. … Sugamura K. (J. Biol. Chem. 1999) 3 4 23
  2. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache K.G. … Stenmark H. (J. Biol. Chem. 2003) 3 4 23
  3. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PMID: 9407053) Asao H. … Sugamura K. (J. Biol. Chem. 1997) 3 4 23
  4. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PMID: 8780729) Takeshita T. … Sugamura K. (Biochem. Biophys. Res. Commun. 1996) 2 3 4
  5. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy. (PMID: 19111546) Hong Y.H. … Lee B.J. (FEBS Lett. 2009) 3 23

Products for STAM Gene

  • Addgene plasmids for STAM

Sources for STAM Gene

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