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Aliases for STAM Gene

Aliases for STAM Gene

  • Signal Transducing Adaptor Molecule 2 3 5
  • Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 1 2 3
  • STAM-1 3 4
  • STAM1 3 4
  • HSE1 Homolog (S. Cerevisiae) 2
  • HSE1 Homolog 3

External Ids for STAM Gene

Previous GeneCards Identifiers for STAM Gene

  • GC10P017668
  • GC10P017836
  • GC10P017690
  • GC10P017726
  • GC10P017686
  • GC10P017598

Summaries for STAM Gene

Entrez Gene Summary for STAM Gene

  • This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for STAM Gene

STAM (Signal Transducing Adaptor Molecule) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Endocytosis. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is TOM1L1.

UniProtKB/Swiss-Prot for STAM Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Gene Wiki entry for STAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAM Gene

Genomics for STAM Gene

Regulatory Elements for STAM Gene

Promoters for STAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STAM on UCSC Golden Path with GeneCards custom track

Genomic Location for STAM Gene

Chromosome:
10
Start:
17,644,125 bp from pter
End:
17,716,824 bp from pter
Size:
72,700 bases
Orientation:
Plus strand

Genomic View for STAM Gene

Genes around STAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAM Gene

Proteins for STAM Gene

  • Protein details for STAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92783-STAM1_HUMAN
    Recommended name:
    Signal transducing adapter molecule 1
    Protein Accession:
    Q92783
    Secondary Accessions:
    • B0YJ99
    • D3DRU5
    • Q8N6D9

    Protein attributes for STAM Gene

    Size:
    540 amino acids
    Molecular mass:
    59180 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB.

    Three dimensional structures from OCA and Proteopedia for STAM Gene

    Alternative splice isoforms for STAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAM Gene

Proteomics data for STAM Gene at MOPED

Post-translational modifications for STAM Gene

  • Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
  • Ubiquitination at Lys 99, Lys 133, Lys 154, Lys 185, and Lys 373
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STAM (STAM1)

No data available for DME Specific Peptides for STAM Gene

Domains & Families for STAM Gene

Gene Families for STAM Gene

Suggested Antigen Peptide Sequences for STAM Gene

Graphical View of Domain Structure for InterPro Entry

Q92783

UniProtKB/Swiss-Prot:

STAM1_HUMAN :
  • The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
  • Belongs to the STAM family.
Domain:
  • The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
  • Contains 1 ITAM domain.
  • Contains 1 SH3 domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the STAM family.
genes like me logo Genes that share domains with STAM: view

Function for STAM Gene

Molecular function for STAM Gene

GENATLAS Biochemistry:
signal-transducin adaptor molecule involved in cytokine-mediated signal transduction
UniProtKB/Swiss-Prot Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
genes like me logo Genes that share phenotypes with STAM: view

Animal Models for STAM Gene

MGI Knock Outs for STAM:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAM Gene

Localization for STAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAM Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAM Gene COMPARTMENTS Subcellular localization image for STAM gene
Compartment Confidence
cytosol 5
endosome 5
lysosome 2
nucleus 2
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031901 early endosome membrane IEA --
GO:0033565 ESCRT-0 complex TAS 20588296
genes like me logo Genes that share ontologies with STAM: view

Pathways & Interactions for STAM Gene

genes like me logo Genes that share pathways with STAM: view

Pathways by source for STAM Gene

SIGNOR curated interactions for STAM Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 8780729
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0036258 multivesicular body assembly TAS 20588296
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with STAM: view

Drugs & Compounds for STAM Gene

(1) Drugs for STAM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for STAM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STAM: view

Transcripts for STAM Gene

Unigene Clusters for STAM Gene

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAM Gene

No ASD Table

Relevant External Links for STAM Gene

GeneLoc Exon Structure for
STAM
ECgene alternative splicing isoforms for
STAM

Expression for STAM Gene

mRNA expression in normal human tissues for STAM Gene

Protein differential expression in normal tissues from HIPED for STAM Gene

This gene is overexpressed in Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAM Gene



SOURCE GeneReport for Unigene cluster for STAM Gene Hs.335391

mRNA Expression by UniProt/SwissProt for STAM Gene

Q92783-STAM1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with STAM: view

Protein tissue co-expression partners for STAM Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for STAM Gene

Orthologs for STAM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAM 35
  • 99.51 (n)
  • 99.81 (a)
STAM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAM 36
  • 94 (a)
OneToOne
STAM 35
  • 89.95 (n)
  • 93.35 (a)
dog
(Canis familiaris)
Mammalia STAM 35
  • 92.38 (n)
  • 95.54 (a)
STAM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stam 16
Stam 36
  • 91 (a)
OneToOne
Stam 35
  • 88.48 (n)
  • 92.47 (a)
oppossum
(Monodelphis domestica)
Mammalia STAM 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAM 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stam 35
  • 87.45 (n)
  • 91.51 (a)
chicken
(Gallus gallus)
Aves STAM 36
  • 87 (a)
OneToOne
STAM 35
  • 81.34 (n)
  • 88.05 (a)
lizard
(Anolis carolinensis)
Reptilia STAM 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76231 35
stam 35
  • 73.14 (n)
  • 80.39 (a)
zebrafish
(Danio rerio)
Actinopterygii stam 36
  • 76 (a)
OneToOne
stam 35
  • 72.36 (n)
  • 81.12 (a)
wufv75b10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008494 35
  • 53.1 (n)
  • 51.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Stam 36
  • 33 (a)
OneToMany
Stam 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea stam-1 35
  • 47.82 (n)
  • 35.63 (a)
stam-1 36
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2766 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1021 36
  • 40 (a)
OneToMany
Species with no ortholog for STAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAM Gene

ENSEMBL:
Gene Tree for STAM (if available)
TreeFam:
Gene Tree for STAM (if available)

Paralogs for STAM Gene

Paralogs for STAM Gene

(7) SIMAP similar genes for STAM Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STAM: view

Variants for STAM Gene

Sequence variations from dbSNP and Humsavar for STAM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036348 A colorectal cancer sample
rs1359506 -- 17,699,188(-) AAAAA(C/G)TTTTG intron-variant
rs1359507 -- 17,698,794(-) TTGAC(A/G)CGCAA intron-variant
rs2357293 -- 17,662,889(+) CTGGG(C/T)ACCAA intron-variant
rs2357294 -- 17,669,905(+) ttttg(G/T)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAM Gene

Variant ID Type Subtype PubMed ID
esv2618457 CNV Insertion 19546169
esv268267 CNV Insertion 20981092
esv269515 CNV Insertion 20981092

Variation tolerance for STAM Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAM Gene

HapMap Linkage Disequilibrium report
STAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAM Gene

Disorders for STAM Gene

Relevant External Links for STAM

Genetic Association Database (GAD)
STAM
Human Genome Epidemiology (HuGE) Navigator
STAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAM

No disorders were found for STAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAM Gene

Publications for STAM Gene

  1. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PMID: 8780729) Takeshita T. … Sugamura K. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 67
  2. AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. (PMID: 20159979) Sierra M.I. … Nash P.D. (J. Biol. Chem. 2010) 3 23
  3. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy. (PMID: 19111546) Hong Y.H. … Lee B.J. (FEBS Lett. 2009) 3 23
  4. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. (PMID: 16431367) McCullough J. … UrbAc S. (Curr. Biol. 2006) 3 23
  5. The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. (PMID: 16520378) Row P.E. … Urbe S. (J. Biol. Chem. 2006) 3 23

Products for STAM Gene

Sources for STAM Gene

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