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STAM Gene

protein-coding   GIFtS: 63
GCID: GC10P017686

Signal Transducing Adaptor Molecule (SH3 Domain And ITAM...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 11 2
STAM-12 3
STAM12 3
HSE1 Homolog (S. Cerevisiae)1
HSE1 Homolog2
Signal Transducing Adapter Molecule 12

External Ids:    HGNC: 113571   Entrez Gene: 80272   Ensembl: ENSG000001367387   OMIM: 6018995   UniProtKB: Q927833   

Export aliases for STAM gene to outside databases

Previous GC identifers: GC10P017668 GC10P017836 GC10P017690 GC10P017726 GC10P017598


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAM Gene:
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream
signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat
protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form
the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to
the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for
this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for STAM Gene:
STAM (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1) is a protein-coding gene. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is STAM2.

UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and
GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role
in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs)
when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that
recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking
processes

Gene Wiki entry for STAM (Signal transducing adaptor molecule) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAM gene promoter:
         GR   RP58   Lmo2   CREB   MEF-2A   Pax-3   Ik-2   deltaCREB   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAM promoter sequence
   Search Chromatin IP Primers for STAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14-p13   Ensembl cytogenetic band:  10p12.33   HGNC cytogenetic band: 10p14-p13

STAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAM gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P017686:  view genomic region     (about GC identifiers)

Start:
17,686,124 bp from pter      End:
17,758,823 bp from pter
Size:
72,700 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003315932 72,916-145,615     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783 (See protein sequence)
Recommended Name: Signal transducing adapter molecule 1  
Size: 540 amino acids; 59180 Da
Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least
composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB
3 PDB 3D structures from and Proteopedia for STAM:
2L0A (3D)        3F1I (3D)        3LDZ (3D)    
Secondary accessions: B0YJ99 D3DRU5 Q8N6D9
Alternative splicing: 2 isoforms:  Q92783-1   Q92783-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for STAM: NX_Q92783

Explore proteomics data for STAM at MOPED

Post-translational modifications: 

  • Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB.
    Phosphorylated by activated PDGFRB1
  • Ubiquitination2 at Lys99, Lys133, Lys154, Lys185, Lys373
  • Modification sites at PhosphoSitePlus

  • See STAM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003464.1  
    ENSEMBL proteins: 
     ENSP00000366746   ENSP00000400025   ENSP00000366721   ENSP00000438073  
    Reactome Protein details: Q92783

    STAM Human Recombinant Protein Products:

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    Novus Biologicals STAM Protein
    Novus Biologicals STAM Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for STAM (4 products) 

     
    antibodies-online peptides for STAM

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    antibodies-online antibodies for STAM (49 products) 

    STAM Assay Products:

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    antibodies-online kits for STAM (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002014 VHS
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS
     IPR001452 SH3_domain
     IPR003903 Ubiquitin-int_motif

    Graphical View of Domain Structure for InterPro Entry Q92783

    ProtoNet protein and cluster: Q92783

    3 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB002014 VHS
    IPB003110 Phosphorylated immunoreceptor signaling ITAM


    UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
    Domain: The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos
    Similarity: Belongs to the STAM family
    Similarity: Contains 1 ITAM domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat
    Similarity: Contains 1 VHS domain


    Find genes that share domains with STAM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAM1_HUMAN, Q92783
    Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and
    GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role
    in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs)
    when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that
    recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking
    processes

         Genatlas biochemistry entry for STAM:
    signal-transducin adaptor molecule involved in cytokine-mediated signal transduction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS8780729
    GO:0005515protein binding IPI10383417
         
    Find genes that share ontologies with STAM           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAM:
     Increased cell death HMECs cel 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Stam):
     behavior/neurological  growth/size/body  hematopoietic system  immune system  mortality/aging 
     nervous system  reproductive system 

    Find genes that share phenotypes with STAM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Stamtm1Sug for STAM

       genOway: Develop your customized and physiologically relevant rodent model for STAM

    miRNA
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    miRTarBase miRNAs that target STAM:
    hsa-let-7e-5p (MIRT051525), hsa-mir-215-5p (MIRT024512), hsa-mir-192-5p (MIRT026819)

    Block miRNA regulation of human, mouse, rat STAM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAM (see all 30):
    hsa-miR-142-3p hsa-miR-562 hsa-miR-548v hsa-miR-488 hsa-miR-197 hsa-miR-9 hsa-miR-144 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidSTAM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STAM

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    Addgene plasmids for STAM 

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    eBioscience FlowRNA Probe Sets ( VA1-12198) for STAM 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAM1_HUMAN, Q92783: Cytoplasm (Probable). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
    (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    lysosome2
    nucleus2
    vacuole2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with STAM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAM About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.83
    Signaling by EGFR in Cancer0.82
    2Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Signaling by GPCR
    Signal Transduction0.58
    4TGF-Beta Pathway
    JAK-STAT Pathway0.57
    5IL2-mediated signaling events
    IL2-mediated signaling events0.49


    Find genes that share SuperPaths with STAM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STAM
        JAK-STAT Pathway

    3 BioSystems Pathways for STAM
        IL-4 signaling Pathway
    IL-7 Signaling Pathway
    IL2-mediated signaling events

    2 Reactome Pathways for STAM
        Endosomal Sorting Complex Required For Transport (ESCRT)
    EGFR downregulation


    2 Kegg Pathways  (Kegg details for STAM):
        Endocytosis
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including STAM: 
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for STAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAM (Q927831, 2, 3 ENSP000003667464) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBBP0CG531, 2EBI-752333,EBI-5333021 MINT-7896489 MINT-7898346 MINT-7898472 MINT-7896471 MINT-7896447 MINT-7898332 MINT-7896423 MINT-7896624 MINT-7896705
    LCP2Q130941, 2, 3, ENSP000000467944EBI-752333,EBI-346946 MINT-4302459 MINT-4302560 MINT-4302518 I2D: score=1 STRING: ENSP00000046794
    PPP1CAP621362, 3, ENSP000003260314MINT-62195 I2D: score=3 STRING: ENSP00000326031
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145828 I2D: score=1 STRING: ENSP00000350297
    MED28Q9H2042, 3, ENSP000002373804MINT-7041809 I2D: score=1 STRING: ENSP00000237380
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction TAS8780729
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0009967positive regulation of signal transduction TAS8780729
    GO:0016197endosomal transport TAS--

    Find genes that share ontologies with STAM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAM (STAM1)

    2 Novoseek inferred chemical compound relationships for STAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 98.5 100 9133424 (7), 15113837 (7), 10231582 (6), 12972556 (5) (see all 30)
    tyrosine 35.8 7 9133424 (2), 10383417 (1), 10329004 (1), 9407053 (1) (see all 5)



    Find genes that share compounds with STAM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAM gene: 
    NM_003473.3  

    Unigene Cluster for STAM:

    Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
    Hs.335391  [show with all ESTs]
    Unigene Representative Sequence: NM_003473
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377524(uc001ipj.2 uc010qcf.2 uc009xjw.2) ENST00000445846
    ENST00000377500 ENST00000486183 ENST00000494250 ENST00000540523
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    hsa-miR-142-3p hsa-miR-562 hsa-miR-548v hsa-miR-488 hsa-miR-197 hsa-miR-9 hsa-miR-144 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidSTAM 3' UTR sequence
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    Additional mRNA sequence: 

    AK303083.1 AK314405.1 BX647982.1 NR_037774.1 U43899.1 

    13 DOTS entries:

    DT.417407  DT.100789063  DT.95069537  DT.91971542  DT.40117266  DT.417402  DT.97786408  DT.100027100 
    DT.95069528  DT.100769058  DT.121619797  DT.40267905  DT.92433048 

    Selected AceView cDNA sequences (see all 146):

    CB146993 AL695091 AA970559 BQ023148 AA411005 AL598610 BM922271 BC030586 
    BP350557 AA278797 BM724197 BM719188 BM453710 BM453429 AW196913 BU163838 
    N77835 BP354835 BM683143 AW606994 AW862561 AL597599 AA045382 BP363068 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    STAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACAAAATT
    STAM Expression
    About this image


    STAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    STAM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335391

    UniProtKB/Swiss-Prot: STAM1_HUMAN, Q92783
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including STAM: 
              JAK / STAT Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STAM gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stam1 , 5 signal transducing adaptor molecule (SH3 domain and more1, 5 88.48(n)1
    92.47(a)1
      2 (10.36 cM)5
    208441  NM_011484.21  NP_035614.11 
     140741005 
    chicken
    (Gallus gallus)
    Aves STAM1 signal transducing adaptor molecule (SH3 domain and more 81.34(n)
    88.05(a)
      420517  XM_418619.4  XP_418619.4 
    lizard
    (Anolis carolinensis)
    Reptilia STAM6
    signal transducing adaptor molecule (SH3 domain an...
    84(a)
    1 ↔ 1
    6(18126805-18144038)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC762312 hypothetical protein MGC76231 77.24(n)    BC063925.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufv75b102 wufv75b10 78.13(n)   386967  BC045442.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Stam3 regulation of JAK-STAT cascade JAK
    pathway signal more
    45(a)   32B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea stam-11 stam-1 47.82(n)
    35.63(a)
      172264  NM_059309.6  NP_491710.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSE16
    Subunit of the endosomal Vps27p-Hse1p complex requ...
    25(a)
    1 → many
    VIII(102612-103970) YHL002W


    ENSEMBL Gene Tree for STAM (if available)
    TreeFam Gene Tree for STAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAM gene
    STAM22  TOM1L22  TOM1L12  TOM12  
    7 SIMAP similar genes for STAM using alignment to 4 protein entries:     STAM1_HUMAN (see all proteins):
    STAM2    SH3GL1    ARHGEF7    DLG2    SH3GL2    ITSN2
    SORBS3

    Find genes that share paralogs with STAM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAM (see all 1876)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363484
    A colorectal cancer sample4--see VAR_0363482 G D mis40--------
    rs1920670641,2
    --17684198(+) AGAATA/CTTGCC 2 -- us2k10--------
    rs727807901,2
    C,F--17684237(+) TCATGT/CATTTC 2 -- us2k12Minor allele frequency- C:0.28NA 122
    rs22515961,2
    C,F,O,A,H--17684398(+) TTTAAT/CTGACC 2 -- us2k1 tfbs328Minor allele frequency- C:0.36NA NS EA WA CSA 2493
    rs115918041,2
    C,H--17684577(+) ACTCAA/C/GTGTGG 2 -- us2k13NA WA 122
    rs1402970881,2
    --17684640(+) ACCTTG/TGTTCA 2 -- us2k10--------
    rs800394281,2
    C,F--17684696(+) GCTGGG/ATCCTA 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1842879571,2
    --17684713(+) TAAAAA/TTTTTT 2 -- us2k10--------
    rs1885354751,2
    --17684783(+) AGTATG/TTGAGT 2 -- us2k10--------
    rs618422621,2
    C,F--17684871(+) ATTCCG/CAGCCT 2 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for STAM (17686124 - 17758823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for STAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2618457CNV Insertion19546169
    esv269515CNV Insertion20981092
    esv268267CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAM
    DNA2.0 Custom Variant and Variant Library Synthesis for STAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601899    OMIM disorders: --


    Find genes that share disorders with STAM           About GenesLikeMe

    Genetic Association Database (GAD): STAM
    Human Genome Epidemiology (HuGE) Navigator: STAM (6 documents)

    Export disorders for STAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAM gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with STAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PubMed id 8780729)1, 2, 3 Takeshita T.... Sugamura K. (Biochem. Biophys. Res. Commun. 1996)
    2. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PubMed id 9407053)1, 2, 9 Asao H.... Sugamura K. (J. Biol. Chem. 1997)
    3. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)1, 2, 9 Bache K.G.... Stenmark H. (J. Biol. Chem. 2003)
    4. Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines. (PubMed id 10383417)1, 2, 9 Tanaka N.... Sugamura K. (J. Biol. Chem. 1999)
    5. VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. (PubMed id 20150893)1, 2 Ren X. and Hurley J.H. (EMBO J. 2010)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. (PubMed id 11687594)1, 2 Steen H.... Mann M. (J. Biol. Chem. 2002)
    10. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. (PubMed id 15113837)1, 9 Mizuno E....Komada M. (J. Biochem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8027 HGNC: 11357 AceView: STAM Ensembl:ENSG00000136738 euGenes: HUgn8027
    ECgene: STAM Kegg: 8027 H-InvDB: STAM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for STAM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAM gene:
    Search GeneIP for patents involving STAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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