STAG3L3 Gene
protein-coding GIFtS: 32
GCID: GC07M072440
|
|
stromal antigen 3-like 3
| |
Aliases
for STAG3L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Stromal Antigen 3-Like 31 2 | | STAG3L12 | | STAG3L22 | | Stromal Antigen 3-Like Protein 33 |
Export aliases for STAG3L3 gene to outside databasesPrevious GC identifers: GC07M072109 GC07M071801 |
Summaries
for STAG3L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for STAG3L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STAG3L3 gene promoter:
C/EBPbeta NF-YA CBF-C Evi-1 FAC1 CBF-A CBF-B CP1A CP1C NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for STAG3L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAG3L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23STAG3L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M072440: view genomic region
(about GC identifiers)
Start:
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72,440,227 bp from pter |
End:
|
72,476,455 bp from pter |
Size:
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36,229 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 71,801,835-71,809,277 |
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Proteins
for STAG3L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ST3L3_HUMAN, P0CL85 (See
protein sequence)Recommended Name: STAG3-like protein 3 Size: 134 amino acids; 15609 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A6NMT8 A8K0A1 Q32NE4 Q6NXR2 Q7L5M5 Q7Z5K6Alternative splicing: 2 isoforms: P0CL85-1 P0CL85-2 Explore the universe of human proteins at neXtProt for STAG3L3: NX_P0CL85
STAG3L3 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000406098 ENSP00000402947 ENSP00000401427 ENSP00000396814 ENSP00000455704 ENSP00000312329 ENSP00000393385
Human Recombinant Protein Products for STAG3L3:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
STAG3L3 for ontologies About GeneDecksing
STAG3L3 Antibody Products:
Assay Products for STAG3L3: |
Protein
Domains /
Families
for STAG3L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STAG3L3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CL85ProtoNet protein and cluster: P0CL85 UniProtKB/Swiss-Prot: ST3L3_HUMAN, P0CL85Similarity: Belongs to the SCC3 familySimilarity: Contains 1 SCD (stromalin conservative) domain |
Function
for STAG3L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAG3L3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAG3L3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAG3L3 |
|
Pathways & Interactions
for STAG3L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STAG3L3
|
Drugs & Compounds
for STAG3L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STAG3L3
Search CenterWatch for drugs/clinical trials and news about STAG3L3 / ST3L3
|
Transcripts
for STAG3L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STAG3L3 gene: NM_001013739.2 7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000436857(uc003twv.3 uc011kem.2) ENST00000428423(uc003txa.3 uc022afo.1)
ENST00000448173 ENST00000423834(uc022afq.1 uc010laq.1) ENST00000569650
ENST00000308103(uc022afn.1 uc022afp.1) ENST00000426587
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAG3L3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAG3L3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STAG3L3 (NM_001013739) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAG3L3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAG3L3 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAG3L3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STAG3L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAG3L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAG3L3 |
GeneLoc Exon Structure
|
Expression
for STAG3L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STAG3L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See STAG3L3 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for STAG3L3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAG3L3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat STAG3L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAG3L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAG3L3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAG3L3 |
Orthologs
for STAG3L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for STAG3L3 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
7(a) |
1 → many |
GL343882.1(39323-62152) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-269e2.16 |
si:ch211-269e2.1 |
5(a) |
1 → many |
9(35404357-35454541) |
fruit fly
(Drosophila melanogaster) |
Insecta |
SA6SA-26 |
Stromalin-2 |
6(a)3(a) |
many ↔ manymany ↔ many |
2L(6950440-6954590) 3L(1434336-1437872) |
worm
(Caenorhabditis elegans) |
Secernentea |
scc-36 |
yeast SCC (mitotic condensin subunit) homolog fami... |
4(a) |
1 → many |
V(12763928-12767921) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SCC36 |
cohesin complex subunit SA-1/2 |
4(a) |
1 → many |
2(19631259-19636978) |
rice
(Oryza sativa) |
Liliopsida |
-- |
SCC3, putative, expressed |
4(a) |
1 → many |
5(5424284-5433068) |
ENSEMBL Gene Tree for STAG3L3 (if available)
TreeFam Gene Tree for STAG3L3 (if available) |
Paralogs
for STAG3L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STAG3L3 gene
- STAG12 STAG32 STAG22
5 SIMAP similar genes for STAG3L3 using alignment to 6 protein entries: ST3L3_HUMAN (see all proteins):STAG3L1 STAG3L2 STAG3 STAG1 STAG2
STAG3L3 for paralogs About GeneDecksing
|
Genomic Variants
for STAG3L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STAG3L3 (72440227 - 72476455 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for STAG3L3
6 CNVs: 2103 2699 69954 3685 4541 8567 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for STAG3L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STAG3L3 for disorders About GeneDecksing
1  disease for STAG3L3: About MalaCardswilliams-beuren syndrome
Export disorders for STAG3L3 gene to outside databases
|
Publications
for STAG3L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STAG3L3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with STAG3L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams- Beuren syndrome deletion. (PubMed id 10698974)1 Pezzi N.... Barbero J.L. (2000)
|
External Searches for STAG3L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STAG3L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STAG3L3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STAG3L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STAG3L3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STAG3L3 gene:
Search GeneIP for patents involving STAG3L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STAG3L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAG3L3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAG3L3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAG3L3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAG3L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAG3L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAG3L3 |
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| |  |  |  |  | | | | |
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 | | | STAG3L3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAG3L3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for STAG3L3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAG3L3 |
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