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Aliases for STAG2 Gene

Aliases for STAG2 Gene

  • Stromal Antigen 2 2 3 4 5
  • SCC3 Homolog 2 3 4
  • SA2 3 4
  • Cohesin Subunit SA-2 3
  • BA517O1.1 3
  • SCC3B 3
  • SA-2 3

External Ids for STAG2 Gene

Previous GeneCards Identifiers for STAG2 Gene

  • GC0XP117813
  • GC0XP120049
  • GC0XP121046
  • GC0XP121793
  • GC0XP122821
  • GC0XP122922
  • GC0XP123094
  • GC0XP112478

Summaries for STAG2 Gene

Entrez Gene Summary for STAG2 Gene

  • The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

CIViC summary for STAG2 Gene

GeneCards Summary for STAG2 Gene

STAG2 (Stromal Antigen 2) is a Protein Coding gene. Diseases associated with STAG2 include Laryngotracheitis and Tracheitis. Among its related pathways are DNA Damage and Cell Cycle, Mitotic. GO annotations related to this gene include chromatin binding and binding. An important paralog of this gene is STAG1.

UniProtKB/Swiss-Prot for STAG2 Gene

  • Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Gene Wiki entry for STAG2 Gene

Additional gene information for STAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAG2 Gene

Genomics for STAG2 Gene

Regulatory Elements for STAG2 Gene

Enhancers for STAG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH124341 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +385.4 385395 8 LEF1 TBL1XR1 TAL1 ZKSCAN1 CHAMP1 CCNT2 TCF12 CC2D1A ZNF316 GATA2 SH2D1A STAG2 ENSG00000226532 GC0XM124376
GH0XH124010 0.4 FANTOM5 2.6 +50.5 50543 0 SCRT2 XIAP STAG2 GC0XP123987 GC0XP123988 GC0XM124101
GH0XH123994 0.6 FANTOM5 Ensembl 1.5 +34.9 34895 0 XIAP STAG2 GC0XP123988 GC0XP123987 GC0XM124101
GH0XH123951 0.9 ENCODE dbSUPER 0.4 -8.1 -8136 1 GATAD2A SOX6 CHD4 CEBPG THRB GABPA KAT8 ETV4 CEBPA HNF4G LOC100422369 RNU6-122P XIAP-AS1 STAG2
GH0XH123953 0.7 ENCODE 0.4 -6.6 -6626 0 HDAC1 ELF3 GATAD2A FOXA2 CEBPB CEBPG RARA ZNF7 SMARCA4 CEBPA LOC100422369 RNU6-122P XIAP-AS1 LOC101928402 STAG2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STAG2 on UCSC Golden Path with GeneCards custom track

Promoters for STAG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248574 1589 6000 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766

Genomic Location for STAG2 Gene

Chromosome:
X
Start:
123,960,212 bp from pter
End:
124,422,664 bp from pter
Size:
462,453 bases
Orientation:
Plus strand

Genomic View for STAG2 Gene

Genes around STAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAG2 Gene

Proteins for STAG2 Gene

  • Protein details for STAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3U4-STAG2_HUMAN
    Recommended name:
    Cohesin subunit SA-2
    Protein Accession:
    Q8N3U4
    Secondary Accessions:
    • B1AMT5
    • D3DTF5
    • O00540
    • Q5JTI6
    • Q68DE9
    • Q9H1N8

    Protein attributes for STAG2 Gene

    Size:
    1231 amino acids
    Molecular mass:
    141326 Da
    Quaternary structure:
    • Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3.
    SequenceCaution:
    • Sequence=CAA99732.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STAG2 Gene

    Alternative splice isoforms for STAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAG2 Gene

Post-translational modifications for STAG2 Gene

  • Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).
  • Ubiquitination at Lys363, posLast=449449, Lys607, Lys622, and posLast=664664
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STAG2 Gene

Domains & Families for STAG2 Gene

Gene Families for STAG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for STAG2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for STAG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3U4

UniProtKB/Swiss-Prot:

STAG2_HUMAN :
  • Belongs to the SCC3 family.
Family:
  • Belongs to the SCC3 family.
genes like me logo Genes that share domains with STAG2: view

Function for STAG2 Gene

Molecular function for STAG2 Gene

UniProtKB/Swiss-Prot Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Gene Ontology (GO) - Molecular Function for STAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15855230
genes like me logo Genes that share ontologies with STAG2: view
genes like me logo Genes that share phenotypes with STAG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAG2 Gene

Localization for STAG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAG2 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAG2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for STAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 16682347
GO:0005634 nucleus TAS 9305759
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome TAS --
genes like me logo Genes that share ontologies with STAG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STAG2 Gene

Pathways & Interactions for STAG2 Gene

genes like me logo Genes that share pathways with STAG2: view

Pathways by source for STAG2 Gene

2 Cell Signaling Technology pathways for STAG2 Gene
1 BioSystems pathway for STAG2 Gene
1 KEGG pathway for STAG2 Gene
1 GeneGo (Thomson Reuters) pathway for STAG2 Gene
1 Qiagen pathway for STAG2 Gene

SIGNOR curated interactions for STAG2 Gene

Activates:

Gene Ontology (GO) - Biological Process for STAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
GO:0007062 sister chromatid cohesion TAS,IMP --
GO:0032876 negative regulation of DNA endoreduplication IMP 15917200
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with STAG2: view

Drugs & Compounds for STAG2 Gene

No Compound Related Data Available

Transcripts for STAG2 Gene

Unigene Clusters for STAG2 Gene

Stromal antigen 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:

ExUns: 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for STAG2 Gene

GeneLoc Exon Structure for
STAG2
ECgene alternative splicing isoforms for
STAG2

Expression for STAG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAG2 Gene

Protein differential expression in normal tissues from HIPED for STAG2 Gene

This gene is overexpressed in Blymphocyte (8.4), Lymph node (8.2), Cerebrospinal fluid (7.2), Fetal gut (7.1), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STAG2 Gene



Protein tissue co-expression partners for STAG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STAG2 Gene:

STAG2

SOURCE GeneReport for Unigene cluster for STAG2 Gene:

Hs.496710

Evidence on tissue expression from TISSUES for STAG2 Gene

  • Nervous system(4.6)
  • Eye(4.2)
  • Liver(4.2)
  • Spleen(2.2)
  • Lung(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with STAG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAG2 Gene

Orthologs for STAG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAG2 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAG2 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAG2 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAG2 33 34
  • 96.21 (n)
cow
(Bos Taurus)
Mammalia STAG2 33 34
  • 96.03 (n)
rat
(Rattus norvegicus)
Mammalia Stag2 33
  • 94.21 (n)
mouse
(Mus musculus)
Mammalia Stag2 33 16 34
  • 93.91 (n)
chicken
(Gallus gallus)
Aves STAG2 33 34
  • 85.79 (n)
lizard
(Anolis carolinensis)
Reptilia STAG2 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stag1 33
  • 80.98 (n)
Str.15852 33
zebrafish
(Danio rerio)
Actinopterygii stag2a 34
  • 78 (a)
OneToMany
stag2b 33 34
  • 74.3 (n)
Dr.4818 33
fruit fly
(Drosophila melanogaster)
Insecta SA 35 34
  • 47 (a)
SA-2 34
  • 24 (a)
ManyToMany
CG13916 35
  • 23 (a)
worm
(Caenorhabditis elegans)
Secernentea scc-3 33 34
  • 47.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRR1 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToMany
Species where no ortholog for STAG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAG2 Gene

ENSEMBL:
Gene Tree for STAG2 (if available)
TreeFam:
Gene Tree for STAG2 (if available)

Paralogs for STAG2 Gene

Variants for STAG2 Gene

Sequence variations from dbSNP and Humsavar for STAG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000016097 -- 124,002,156(+) AGGTT(G/T)CAGTG intron-variant
rs1000027383 -- 123,995,765(+) GAATG(G/T)CGCTT intron-variant
rs1000036753 -- 123,986,162(+) ATATG(A/C)TACAT intron-variant
rs1000048573 -- 124,019,243(+) TTTTA(A/G)TAGAG intron-variant
rs1000101904 -- 124,018,913(+) CATCC(A/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAG2 Gene

Variant ID Type Subtype PubMed ID
esv2758890 CNV gain 17122850
esv3427436 CNV insertion 20981092
esv3574516 CNV loss 25503493
nsv438155 CNV loss 16468122
nsv953694 CNV duplication 24416366

Variation tolerance for STAG2 Gene

Residual Variation Intolerance Score: 2.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAG2 Gene

Human Gene Mutation Database (HGMD)
STAG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAG2 Gene

Disorders for STAG2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for STAG2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
laryngotracheitis
tracheitis
  • acute tracheitis
embryonal testis carcinoma
  • embryonal carcinoma of testis
lip disease
  • disease of lips
cornelia de lange syndrome
  • brachmann de lange syndrome
- elite association - COSMIC cancer census association via MalaCards
Search STAG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for STAG2

Genetic Association Database (GAD)
STAG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAG2
genes like me logo Genes that share disorders with STAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAG2 Gene

Publications for STAG2 Gene

  1. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. (PMID: 9305759) Carramolino L … Zipori D (Gene 1997) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. (PMID: 12034751) Prieto I … Barbero JL (EMBO reports 2002) 3 4 60

Products for STAG2 Gene

  • Addgene plasmids for STAG2

Sources for STAG2 Gene

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