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Aliases for STAG2 Gene

Aliases for STAG2 Gene

  • Stromal Antigen 2 2 3 4
  • SA2 3 4 6
  • SCC3 Homolog 2 3 4
  • Cohesin Subunit SA-2 3
  • BA517O1.1 3
  • SCC3B 3
  • SA-2 3

External Ids for STAG2 Gene

Summaries for STAG2 Gene

Entrez Gene Summary for STAG2 Gene

  • The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for STAG2 Gene

STAG2 (Stromal Antigen 2) is a Protein Coding gene. Diseases associated with STAG2 include laryngotracheitis and tracheitis. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is STAG1.

UniProtKB/Swiss-Prot for STAG2 Gene

  • Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Gene Wiki entry for STAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAG2 Gene

Genomics for STAG2 Gene

Genomic Location for STAG2 Gene

Start:
123,960,212 bp from pter
End:
124,422,664 bp from pter
Size:
462,453 bases
Orientation:
Plus strand

Genomic View for STAG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAG2 Gene

Regulatory Elements for STAG2 Gene

Proteins for STAG2 Gene

  • Protein details for STAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3U4-STAG2_HUMAN
    Recommended name:
    Cohesin subunit SA-2
    Protein Accession:
    Q8N3U4
    Secondary Accessions:
    • B1AMT5
    • D3DTF5
    • O00540
    • Q5JTI6
    • Q68DE9
    • Q9H1N8

    Protein attributes for STAG2 Gene

    Size:
    1231 amino acids
    Molecular mass:
    141326 Da
    Quaternary structure:
    • Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3.
    SequenceCaution:
    • Sequence=CAA99732.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STAG2 Gene

    Alternative splice isoforms for STAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAG2 Gene

Proteomics data for STAG2 Gene at MOPED

Post-translational modifications for STAG2 Gene

  • Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys270, Lys363, Lys449, Lys607, Lys622, Lys664, and Lys965

No data available for DME Specific Peptides for STAG2 Gene

Domains for STAG2 Gene

Protein Domains for STAG2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

STAG2_HUMAN
Domain:
  • Contains 1 SCD (stromalin conservative) domain.:
    • Q8N3U4
Family:
  • Belongs to the SCC3 family.:
    • Q8N3U4
genes like me logo Genes that share domains with STAG2: view

No data available for Gene Families for STAG2 Gene

Function for STAG2 Gene

Molecular function for STAG2 Gene

UniProtKB/Swiss-Prot Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Gene Ontology (GO) - Molecular Function for STAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 15855230
genes like me logo Genes that share ontologies with STAG2: view

Phenotypes for STAG2 Gene

GenomeRNAi human phenotypes for STAG2:
genes like me logo Genes that share phenotypes with STAG2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STAG2 Gene

Localization for STAG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAG2 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAG2 Gene COMPARTMENTS Subcellular localization image for STAG2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for STAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 16682347
GO:0005634 nucleus TAS 9305759
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome TAS --
genes like me logo Genes that share ontologies with STAG2: view

Pathways for STAG2 Gene

genes like me logo Genes that share pathways with STAG2: view

Pathways by source for STAG2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for STAG2 Gene
1 Qiagen pathway for STAG2 Gene
2 Cell Signaling Technology pathways for STAG2 Gene
1 BioSystems pathway for STAG2 Gene
15 Reactome pathways for STAG2 Gene
1 KEGG pathway for STAG2 Gene

Gene Ontology (GO) - Biological Process for STAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007062 sister chromatid cohesion IMP 15917200
GO:0007067 mitotic nuclear division IEA --
GO:0016925 protein sumoylation TAS --
GO:0019827 stem cell maintenance IEA --
genes like me logo Genes that share ontologies with STAG2: view

Transcripts for STAG2 Gene

Unigene Clusters for STAG2 Gene

Stromal antigen 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:

ExUns: 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for STAG2 Gene

GeneLoc Exon Structure for
STAG2
ECgene alternative splicing isoforms for
STAG2

Expression for STAG2 Gene

mRNA expression in normal human tissues for STAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAG2 Gene

SOURCE GeneReport for Unigene cluster for STAG2 Gene Hs.496710

genes like me logo Genes that share expressions with STAG2: view

Orthologs for STAG2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAG2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAG2 36
  • 96.03 (n)
  • 99.76 (a)
STAG2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAG2 36
  • 96.21 (n)
  • 99.68 (a)
STAG2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stag2 36
  • 93.91 (n)
  • 99.11 (a)
Stag2 16
Stag2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAG2 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAG2 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stag2 36
  • 94.21 (n)
  • 99.03 (a)
chicken
(Gallus gallus)
Aves STAG2 36
  • 85.79 (n)
  • 96.37 (a)
STAG2 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAG2 37
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stag1 36
  • 80.98 (n)
  • 90.95 (a)
Str.15852 36
zebrafish
(Danio rerio)
Actinopterygii Dr.4818 36
stag2a 37
  • 78 (a)
OneToMany
stag2b 36
  • 74.3 (n)
  • 86.12 (a)
stag2b 37
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta SA 37
  • 43 (a)
ManyToMany
SA-2 37
  • 24 (a)
ManyToMany
CG13916 38
  • 23 (a)
SA 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea scc-3 36
  • 47.16 (n)
  • 37.44 (a)
scc-3 37
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRR1 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for STAG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAG2 Gene

ENSEMBL:
Gene Tree for STAG2 (if available)
TreeFam:
Gene Tree for STAG2 (if available)

Paralogs for STAG2 Gene

Paralogs for STAG2 Gene

genes like me logo Genes that share paralogs with STAG2: view

Variants for STAG2 Gene

Sequence variations from dbSNP and Humsavar for STAG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs199421 -- 123,983,139(+) CAGCA(A/G)GGTAT intron-variant
rs199422 -- 123,985,726(+) ctacc(A/G)tacca intron-variant
rs199423 -- 123,987,149(+) cacca(C/T)gccca intron-variant
rs199424 -- 123,988,255(+) ACTGG(A/C)TTTTA intron-variant
rs199425 -- 123,993,810(+) tgacc(A/G)tgcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAG2 Gene

Variant ID Type Subtype PubMed ID
dgv2471e1 CNV Complex 17122850
nsv438155 CNV Loss 16468122

Relevant External Links for STAG2 Gene

HapMap Linkage Disequilibrium report
STAG2

Disorders for STAG2 Gene

(3) University of Copenhagen DISEASES for STAG2 Gene

Relevant External Links for STAG2

Genetic Association Database (GAD)
STAG2
genes like me logo Genes that share disorders with STAG2: view

No data available for UniProtKB/Swiss-Prot for STAG2 Gene

Publications for STAG2 Gene

  1. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. (PMID: 9305759) Carramolino L. … Zipori D. (Gene 1997) 2 3 4
  2. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. (PMID: 12034751) Prieto I. … Barbero J.L. (EMBO Rep. 2002) 3 4
  3. Characterization of vertebrate cohesin complexes and their regulation in prophase. (PMID: 11076961) Sumara I. … Peters J.-M. (J. Cell Biol. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for STAG2 Gene

  • Addgene plasmids for STAG2

Sources for STAG2 Gene

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