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STAG2 Gene

protein-coding   GIFtS: 65
GCID: GC0XP123094

Stromal Antigen 2

  See STAG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Stromal Antigen 21 2 3     SCC3B2
SA22 3 5     bA517O1.12
SCC3 Homolog 22 3     Cohesin Subunit SA-22
SA-22     

External Ids:    HGNC: 113551   Entrez Gene: 107352   Ensembl: ENSG000001019727   OMIM: 3008265   UniProtKB: Q8N3U43   
ORGUL members:         

Export aliases for STAG2 gene to outside databases

Previous GC identifers: GC0XP117813 GC0XP120049 GC0XP121046 GC0XP121793 GC0XP122821 GC0XP122922 GC0XP112478


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for STAG2 Gene:
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister
chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and
aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep
2013)

GeneCards Summary for STAG2 Gene:
STAG2 (stromal antigen 2) is a protein-coding gene. Diseases associated with STAG2 include laryngotracheitis, and tracheitis. An important paralog of this gene is STAG1.

UniProtKB/Swiss-Prot: STAG2_HUMAN, Q8N3U4
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA
replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can
be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to
segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

Gene Wiki entry for STAG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAG2 gene promoter:
         SRF   GATA-3   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): STAG2 promoter sequence
   Search Chromatin IP Primers for STAG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25

STAG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAG2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP123094:  view genomic region     (about GC identifiers)

Start:
123,094,062 bp from pter      End:
123,556,514 bp from pter
Size:
462,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STAG2_HUMAN, Q8N3U4 (See protein sequence)
Recommended Name: Cohesin subunit SA-2  
Size: 1231 amino acids; 141326 Da
Subunit: Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between
a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at
their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with
STAG1 and STAG3
Sequence caution: Sequence=CAA99732.1; Type=Erroneous initiation;
Secondary accessions: B1AMT5 D3DTF5 O00540 Q5JTI6 Q68DE9 Q9H1N8
Alternative splicing: 2 isoforms:  Q8N3U4-1   Q8N3U4-2   

Explore the universe of human proteins at neXtProt for STAG2: NX_Q8N3U4

Explore proteomics data for STAG2 at MOPED

Post-translational modifications: 

  • Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to
    its phosphorylation (By similarity)1
  • Ubiquitination2 at Lys270, Lys363, Lys449, Lys607, Lys622, Lys664, Lys965
  • Modification sites at PhosphoSitePlus

  • See STAG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001036214.1  NP_001036215.1  NP_001036216.1  NP_001269347.1  NP_006594.3  

    ENSEMBL proteins: 
     ENSP00000377987   ENSP00000397265   ENSP00000218089   ENSP00000405555   ENSP00000360202  
     ENSP00000405874   ENSP00000360199   ENSP00000360187   ENSP00000401309   ENSP00000360186  
     ENSP00000415103   ENSP00000392118   ENSP00000377988   ENSP00000346555  
    Reactome Protein details: Q8N3U4

    STAG2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for STAG2

     
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    EMD Millipore Mono- and Polyclonal Antibodies for the study of STAG2
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    Search eBioscience for ELISAs for STAG2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020839 SCD
     IPR013721 STAG
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8N3U4

    ProtoNet protein and cluster: Q8N3U4

    1 Blocks protein domain: IPB013721 STAG

    UniProtKB/Swiss-Prot: STAG2_HUMAN, Q8N3U4
    Similarity: Belongs to the SCC3 family
    Similarity: Contains 1 SCD (stromalin conservative) domain


    Find genes that share domains with STAG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAG2_HUMAN, Q8N3U4
    Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA
    replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can
    be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to
    segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15855230
         
    Find genes that share ontologies with STAG2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAG2:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAG2
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    miRNA
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    miRTarBase miRNAs that target STAG2:
    hsa-mir-21-5p (MIRT031017), hsa-mir-155-5p (MIRT020913), hsa-mir-186-5p (MIRT045116), hsa-mir-34a-5p (MIRT025332), hsa-mir-181a-5p (MIRT047306), hsa-mir-193b-3p (MIRT041363), hsa-mir-182-5p (MIRT047201)

    Block miRNA regulation of human, mouse, rat STAG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAG2 (see all 134):
    hsa-miR-100* hsa-miR-3938 hsa-miR-1260b hsa-miR-138-2* hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidSTAG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat STAG2

    Gene Editing
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    Addgene plasmids for STAG2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STAG2_HUMAN, Q8N3U4: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase
    it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin
    probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase,
    the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing
    chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be
    replaced by a meiosis-specific cohesin complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000785chromatin IDA16682347
    GO:0005634nucleus TAS9305759
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome TAS--

    Find genes that share ontologies with STAG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for STAG2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.78
    Establishment of Sister Chromatid Cohesion0.00
    5Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62


    Find genes that share SuperPaths with STAG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for STAG2
        Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for STAG2
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for STAG2
        Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for STAG2
        PLK1 signaling events

    5 Reactome Pathways for STAG2
        Cohesin Loading onto Chromatin
    Establishment of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion
    Separation of Sister Chromatids
    Meiotic synapsis


    1 Kegg Pathway  (Kegg details for STAG2):
        Cell cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STAG2
    Interactions:

        GeneGlobe Interaction Network for STAG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAG2 (Q8N3U41, 2, 3 ENSP000002180894) via UniProtKB, MINT, STRING, and/or I2D (see all 612)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE71, 2, 3, ENSP000003547204EBI-1057252,EBI-80718 MINT-6178106 MINT-8080160 MINT-8081286 MINT-8081321 MINT-6178177 MINT-7914988 MINT-7947479 I2D: score=4 STRING: ENSP00000354720
    STAG1Q8WVM72, 3, ENSP000003726894MINT-6178106 I2D: score=3 STRING: ENSP00000372689
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    RAD21O602162, 3, ENSP000002973384MINT-6178106 MINT-8080160 MINT-8081286 MINT-8081321 MINT-7914988 MINT-8081377 I2D: score=9 STRING: ENSP00000297338
    SSU72Q9NP771, 2, 3, ENSP000002913864EBI-1057252,EBI-2515416 MINT-8080160 MINT-8081286 MINT-8081365 MINT-8081321 MINT-8081377 I2D: score=2 STRING: ENSP00000291386
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007062sister chromatid cohesion IMP15917200
    GO:0007067mitosis IEA--
    GO:0007126meiotic nuclear division IEA--
    GO:0019827stem cell maintenance IEA--

    Find genes that share ontologies with STAG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAG2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for STAG2 gene (5 alternative transcripts): 
    NM_001042749.2  NM_001042750.1  NM_001042751.1  NM_001282418.1  NM_006603.4  

    Unigene Cluster for STAG2:

    Stromal antigen 2
    Hs.496710  [show with all ESTs]
    Unigene Representative Sequence: NM_001042749
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000394477 ENST00000455404 ENST00000218089 ENST00000483575 ENST00000469481
    ENST00000458700 ENST00000371160(uc004eub.3) ENST00000435103 ENST00000371157(uc004eua.3 uc004etz.4 uc004euc.3 uc004eud.3 uc004eue.3)
    ENST00000371145 ENST00000458176 ENST00000371144 ENST00000466748 ENST00000471107
    ENST00000428941 ENST00000435215 ENST00000394478 ENST00000475602
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate STAG2 (see all 134):
    hsa-miR-100* hsa-miR-3938 hsa-miR-1260b hsa-miR-138-2* hsa-miR-3916 hsa-miR-877* hsa-miR-409-5p hsa-miR-1243
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    Addgene plasmids for STAG2 
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      QuantiTect SYBR Green Assays in human, mouse, rat STAG2
      QuantiFast Probe-based Assays in human, mouse, rat STAG2

    Additional mRNA sequence: 

    AK026678.1 AK098737.1 AK298633.1 AK313559.1 AL831939.2 BC001765.1 BC017095.1 BX640970.1 
    BX641002.1 BX641003.1 CR627425.1 CR749433.1 DQ655919.2 DQ655920.2 DQ655921.2 DQ655922.2 

    24 DOTS entries:

    DT.454524  DT.121297128  DT.121297201  DT.101968516  DT.121297207  DT.101984639  DT.121297060  DT.121297187 
    DT.95119222  DT.100640230  DT.100786366  DT.75141305  DT.92007106  DT.95120276  DT.121297091  DT.121297092 
    DT.121297147  DT.121297152  DT.121297173  DT.121297174  DT.91771959  DT.95120295  DT.95125594  DT.91900344 

    Selected AceView cDNA sequences (see all 331):

    AI358187 BF969200 AA830209 AA489057 AU132595 BC017095 BX641003 AA504266 
    BQ690006 BM728575 AW971841 AK026678 BM471798 CA312713 AL708885 AV711824 
    AA811144 CD677427 BE669903 BF434878 BM452406 BI491324 BG255453 AA251764 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for STAG2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b
    SP1:                                      -     -                 -               
    SP2:                                            -                 -               
    SP3:                                            -                                 
    SP4:                                                                              


    ECgene alternative splicing isoforms for STAG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    STAG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAATAACA
    STAG2 Expression
    About this image


    STAG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Spermatid Seminiferous Tubules
    STAG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496710
        Custom PCR Arrays for STAG2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for STAG2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stag21 , 5 stromal antigen 21, 5 93.91(n)1
    99.11(a)1
      X (23.19 cM)5
    208431  NM_001077712.11  NP_001071180.11 
     421493175 
    chicken
    (Gallus gallus)
    Aves STAG21 stromal antigen 2 85.79(n)
    96.37(a)
      422360  XM_003641120.2  XP_003641168.1 
    lizard
    (Anolis carolinensis)
    Reptilia STAG26
    stromal antigen 2
    95(a)
    1 ↔ 1
    GL343409.1(74055-95686)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.158522 Transcribed sequence with weak similarity to protein more 82.04(n)    AL875246.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.48182 Transcribed sequence with weak similarity to protein more 73.6(n)    57063650 
    fruit fly
    (Drosophila melanogaster)
    Insecta SA3   -- 47(a)
    (best of 2)
      27C7   --
    worm
    (Caenorhabditis elegans)
    Secernentea scc-31 scc-3 47.16(n)
    37.44(a)
      179749  NM_073792.3  NP_506193.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IRR16
    Subunit of the cohesin complex, which is required ...
    17(a)
    1 → many
    IX(304477-307929) YIL026C


    ENSEMBL Gene Tree for STAG2 (if available)
    TreeFam Gene Tree for STAG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for STAG2 gene
    STAG12  STAG32  
    12 SIMAP similar genes for STAG2 using alignment to 10 protein entries:     STAG2_HUMAN (see all proteins):
    DKFZp686C21148    DKFZp686P16143    DKFZp686P168    DKFZp686I05169    STAG3L4    DKFZp781D1416
    STAG3L2    STAG3L3    STAG1 variant protein    STAG1    STAG3L1    STAG3

    Find genes that share paralogs with STAG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for STAG2 (see all 1918)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408285771,2
    C--123092599(+) TGAATC/GTATTA 1 -- us2k10--------
    rs1815895001,2
    --123092706(+) AATGTC/TTCAGA 1 -- us2k10--------
    rs1861063421,2
    --123092788(+) AACTCC/TTTTTG 1 -- us2k10--------
    rs1908738641,2
    --123092814(+) AACAAC/TAAGCA 1 -- us2k10--------
    rs1834486291,2
    --123092834(+) GGAGAG/TAAACT 1 -- us2k10--------
    rs1445749051,2
    --123092851(+) AGATAC/TGGAAG 1 -- us2k10--------
    rs1131263121,2
    C,F--123093088(+) TTCTTC/AAGCAA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs349821351,2
    C,F--123094091(+) AGAAGC/AACCGC 4 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1859768511,2
    --123094295(+) GGCTGA/GGAGCC 4 -- us2k10--------
    rs1906999601,2
    --123094657(+) GAAAGA/GAGGAG 4 -- ut51 us2k10--------

    HapMap Linkage Disequilibrium report for STAG2 (123094062 - 123344062 bp, first 250kb of STAG2)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for STAG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv438155CNV Loss16468122
    dgv2471e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAG2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300826    OMIM disorders: --

    3 diseases for STAG2:    
    About MalaCards
    laryngotracheitis    tracheitis    legg-calve-perthes disease

    3 diseases from the University of Copenhagen DISEASES database for STAG2:
    Laryngotracheitis     Tracheitis     Legg-Calve-Perthes Disease

    Find genes that share disorders with STAG2           About GenesLikeMe

    Genetic Association Database (GAD): STAG2

    Export disorders for STAG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for STAG2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with STAG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. (PubMed id 9305759)1, 2, 3 Carramolino L.... Zipori D. (Gene 1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. (PubMed id 12034751)1, 2 Prieto I.... Barbero J.L. (EMBO Rep. 2002)
    6. Characterization of vertebrate cohesin complexes and their regulation in prophase. (PubMed id 11076961)1, 2 Sumara I.... Peters J.-M. (J. Cell Biol. 2000)
    7. Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. (PubMed id 24324008)1 Kong X....Yokomori K. (Mol. Cell. Biol. 2014)
    8. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    9. Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. (PubMed id 23874961)1 Zhang N....Pati D. (PLoS ONE 2013)
    10. Frequent truncating mutations of STAG2 in bladder cancer. (PubMed id 24121789)1 Solomon D.A....Waldman T. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10735 HGNC: 11355 AceView: STAG2 Ensembl:ENSG00000101972 euGenes: HUgn10735
    ECgene: STAG2 Kegg: 10735 H-InvDB: STAG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for STAG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for STAG2 gene:
    Search GeneIP for patents involving STAG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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