Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



STAG1 Gene

protein-coding   GIFtS: 67
GCID: GC03M136055

Stromal Antigen 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Stromal Antigen 11 2 3
SA12 3
SCC3 Homolog 12 3
SCC3A2
Cohesin Subunit SA-12
Nuclear Protein Stromal Antigen 12

External Ids:    HGNC: 113541   Entrez Gene: 102742   Ensembl: ENSG000001180077   OMIM: 6043585   UniProtKB: Q8WVM73   

Export aliases for STAG1 gene to outside databases

Previous GC identifers: GC03M133000 GC03M136806 GC03M137336 GC03M137375 GC03M137537 GC03M133432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for STAG1 Gene:
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a
multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA
replication through prophase and prometaphase, after which it is dissociated in preparation for segregation
during anaphase. (provided by RefSeq, Jul 2008)

GeneCards Summary for STAG1 Gene:
STAG1 (stromal antigen 1) is a protein-coding gene. An important paralog of this gene is STAG3.

UniProtKB/Swiss-Prot: STAG1_HUMAN, Q8WVM7
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA
replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can
be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to
segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

Gene Wiki entry for STAG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the STAG1 gene promoter:
         TBP   MAZR   Sp1   p53   POU3F2   CREB   Pax-3   TFIID   deltaCREB   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSTAG1 promoter sequence
   Search Chromatin IP Primers for STAG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.2-q22.3

STAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STAG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M136055:  view genomic region     (about GC identifiers)

Start:
136,055,077 bp from pter      End:
136,471,245 bp from pter
Size:
416,169 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: STAG1_HUMAN, Q8WVM7 (See protein sequence)
Recommended Name: Cohesin subunit SA-1  
Size: 1258 amino acids; 144427 Da
Subunit: Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between
a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at
their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with
STAG2 and STAG3
Secondary accessions: O00539

Explore the universe of human proteins at neXtProt for STAG1: NX_Q8WVM7

Explore proteomics data for STAG1 at MOPED

Post-translational modifications: 

  • Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to
    its phosphorylation (By similarity)1
  • Ubiquitination2 at Lys273, Lys366
  • Modification sites at PhosphoSitePlus

  • See STAG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005853.2  
    ENSEMBL proteins: 
     ENSP00000372689   ENSP00000236698   ENSP00000419093   ENSP00000418472   ENSP00000419317  
     ENSP00000420789   ENSP00000404396   ENSP00000445787  
    Reactome Protein details: Q8WVM7

    STAG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for STAG1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for STAG1
    GenScript Custom Purified and Recombinant Proteins Services for STAG1
    Novus Biologicals STAG1 Protein
    Novus Biologicals STAG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for STAG1

     
    Search eBioscience for Proteins for STAG1 

    STAG1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for STAG1
    Novus Biologicals STAG1 Antibodies
    Search for Antibodies for STAG1 at Abcam
    Cloud-Clone Corp. Antibodies for STAG1
    ThermoFisher Antibody for STAG1
    LSBio Antibodies in human, mouse, rat for STAG1

    STAG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for STAG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STAG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for STAG1
    Cloud-Clone Corp. CLIAs for STAG1
    Search eBioscience for ELISAs for STAG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR020839 SCD
     IPR013721 STAG
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8WVM7

    ProtoNet protein and cluster: Q8WVM7

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB013721 STAG


    UniProtKB/Swiss-Prot: STAG1_HUMAN, Q8WVM7
    Similarity: Belongs to the SCC3 family
    Similarity: Contains 1 SCD (stromalin conservative) domain


    Find genes that share domains with STAG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STAG1_HUMAN, Q8WVM7
    Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA
    replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can
    be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to
    segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15855230
         
    Find genes that share ontologies with STAG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for STAG1:
     Increased G1 DNA content 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Stag1):
     adipose tissue  cellular  craniofacial  growth/size/body  hematopoietic system 
     homeostasis/metabolism  integument  mortality/aging  muscle  renal/urinary system 
     skeleton  tumorigenesis 

    Find genes that share phenotypes with STAG1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for STAG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for STAG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target STAG1:
    hsa-mir-25-3p (MIRT050227), hsa-mir-26b-5p (MIRT029901), hsa-mir-149-5p (MIRT045515), hsa-mir-128-3p (MIRT022070), hsa-mir-92a-3p (MIRT049410)

    Block miRNA regulation of human, mouse, rat STAG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAG1 (see all 31):
    hsa-miR-142-5p hsa-miR-3934 hsa-miR-579 hsa-miR-4251 hsa-miR-1271 hsa-miR-128 hsa-let-7a-2* hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidSTAG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for STAG1
    Predesigned siRNA for gene silencing in human, mouse, rat STAG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for STAG1

    Clone
    Products:
         
    OriGene clones in human, mouse for STAG1 (see all 6)
    OriGene ORF clones in mouse, rat for STAG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAG1 (NM_005862)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for STAG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for STAG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    STAG1_HUMAN, Q8WVM7: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase
    it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin
    probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase,
    the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing
    chromosome separation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region TAS--
    GO:0000785chromatin IDA16682347
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome TAS--

    Find genes that share ontologies with STAG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for STAG1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    S Phase0.78
    Establishment of Sister Chromatid Cohesion0.00
    5Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62


    Find genes that share SuperPaths with STAG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for STAG1
        Cell cycle Spindle assembly and chromosome separation

    5 Reactome Pathways for STAG1
        Cohesin Loading onto Chromatin
    Establishment of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion
    Separation of Sister Chromatids
    Meiotic synapsis


    1 Kegg Pathway  (Kegg details for STAG1):
        Cell cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for STAG1
    Interactions:

        GeneGlobe Interaction Network for STAG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for STAG1 (Q8WVM71, 2, 3 ENSP000003726894) via UniProtKB, MINT, STRING, and/or I2D (see all 622)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE71, 2, 3, ENSP000003547204EBI-1175097,EBI-80718 MINT-6178106 MINT-6178206 MINT-7945693 MINT-6178091 MINT-6178160 I2D: score=4 STRING: ENSP00000354720
    TERF1P542741, 2, 3, ENSP000002766034EBI-1175097,EBI-710997 MINT-6178206 MINT-6178136 MINT-6178091 MINT-6178188 I2D: score=1 STRING: ENSP00000276603
    STAG2Q8N3U42, 3, ENSP000002180894MINT-6178106 I2D: score=3 STRING: ENSP00000218089
    RAD21O602162, 3, ENSP000002973384MINT-6178106 MINT-6178206 MINT-7945693 MINT-6178091 I2D: score=4 STRING: ENSP00000297338
    CALM1P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with STAG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for STAG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for STAG1 gene: 
    NM_005862.2  

    Unigene Cluster for STAG1:

    Stromal antigen 1
    Hs.412586  [show with all ESTs]
    Unigene Representative Sequence: BC064699
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383202(uc003era.1) ENST00000236698(uc003erb.1) ENST00000483235
    ENST00000465961 ENST00000487065(uc010hua.1) ENST00000492318 ENST00000462818
    ENST00000480733(uc003ere.3) ENST00000434713(uc003erc.1) ENST00000536929

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat STAG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate STAG1 (see all 31):
    hsa-miR-142-5p hsa-miR-3934 hsa-miR-579 hsa-miR-4251 hsa-miR-1271 hsa-miR-128 hsa-let-7a-2* hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidSTAG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for STAG1
    Predesigned siRNA for gene silencing in human, mouse, rat STAG1
    Clone
    Products:
         
    OriGene clones in human, mouse for STAG1 (see all 6)
    OriGene ORF clones in mouse, rat for STAG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: STAG1 (NM_005862)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for STAG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAG1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for STAG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAG1
      QuantiTect SYBR Green Assays in human, mouse, rat STAG1
      QuantiFast Probe-based Assays in human, mouse, rat STAG1

    Additional mRNA sequence: 

    AB210023.1 AK124202.1 AK304381.1 AK309934.1 BC017735.1 BC064699.1 CR749247.1 Z75330.1 

    14 DOTS entries:

    DT.101964909  DT.101984715  DT.92028101  DT.116168  DT.97811438  DT.425749  DT.92022987  DT.95116488 
    DT.120900534  DT.95263771  DT.99946271  DT.100769969  DT.120900475  DT.40257885 

    Selected AceView cDNA sequences (see all 237):

    BF056914 BF796496 AA180440 BQ001502 AA721410 CA406306 BF330420 AW993480 
    BE466892 AA251090 CD238866 AI654118 AA828552 BM718664 BC040708 BQ718426 
    BQ422046 BF112235 CA445814 CA488740 AA757727 CA748941 BF063299 AK124202 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for STAG1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
    SP1:                                -                                       
    SP2:                                -           -                           
    SP3:                                                                        


    ECgene alternative splicing isoforms for STAG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    STAG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACACAAAA
    STAG1 Expression
    About this image


    STAG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    STAG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    STAG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412586
        Custom PCR Arrays for STAG1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for STAG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAG1
    QuantiTect SYBR Green Assays in human, mouse, rat STAG1
    QuantiFast Probe-based Assays in human, mouse, rat STAG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for STAG1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stag11 , 5 stromal antigen 11, 5 92.95(n)1
    99.36(a)1
      9 (52.77 cM)5
    208421  NM_009282.31  NP_033308.21 
     1005977985 
    chicken
    (Gallus gallus)
    Aves STAG11 stromal antigen 1 85.49(n)
    96.82(a)
      424735  XM_422558.4  XP_422558.3 
    lizard
    (Anolis carolinensis)
    Reptilia STAG16
    stromal antigen 1
    96(a)
    1 ↔ 1
    3(34822909-34953926)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34412 Xenopus laevis cohesin subunit XSA1 mRNA, complete more 78.57(n)    AF255017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii stag1a1 stromal antigen 1a 75.16(n)
    86.9(a)
      564533  XM_687862.3  XP_692954.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta SA1 , 3 Stromalin1 48(a)
    (best of 2)3
    52.47(n)1
    49.7(a)1
      27C73
    339741  NM_057920.31  NP_477268.21 
    worm
    (Caenorhabditis elegans)
    Secernentea scc-36
    Protein SCC-3 (scc-3) mRNA, complete cds
    33(a)
    1 → many
    V(12763945-12767938) WBGene00004738
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IRR1(YIL026C)4 Subunit of the cohesin complex, which is required for more   --   9(307929-304477) 854786  NP_012238.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SCC31 SCC3 41.37(n)
    27.7(a)
      819410  NM_130365.3  NP_566119.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01885001 Os05g0188500 40.69(n)
    25.51(a)
      4338016  NM_001061376.1  NP_001054841.1 


    ENSEMBL Gene Tree for STAG1 (if available)
    TreeFam Gene Tree for STAG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for STAG1 gene
    STAG32  STAG22  
    12 SIMAP similar genes for STAG1 using alignment to 7 protein entries:     STAG1_HUMAN (see all proteins):
    STAG1 variant protein    DKFZp781D1416    STAG3L4    DKFZp686I05169    DKFZp686P168    DKFZp686C21148
    DKFZp686P16143    STAG3L3    STAG3L2    STAG3L1    STAG2    STAG3

    Find genes that share paralogs with STAG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for STAG1 (see all 8011)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152715371,2
    F--136055557(+) GAACTG/ATACAA 1 -- ds50011Minor allele frequency- A:0.08WA 118
    rs1858247201,2
    --136055591(+) CTTTAC/GTAAAA 1 -- ds50010--------
    rs1901236701,2
    --136055609(+) TAAAAC/TCATCC 1 -- ds50010--------
    rs1173099181,2
    C,F--136055613(+) ATCATC/TCATCA 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1831120761,2
    --136055901(+) GATTCA/GTAATT 1 -- ds50010--------
    rs171999781,2
    C,F,H--136056184(+) CTTGAA/GTTTGG 1 -- ut31 ese312Minor allele frequency- G:0.11NA NS EA WA CSA 806
    rs1412589251,2
    C--136056198(+) GCATG-/AAAT  
            
    AAATA
    1 -- ut310--------
    rs1152188321,2
    C,F--136056334(+) ATCTCC/TCTAGT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs6965201,2
    C,F,A,H--136056861(-) CTACTG/ATTGGA 1 -- ut31 ese333Minor allele frequency- A:0.47MN EA NA NS WA 4830
    rs1876508051,2
    --136056896(+) CTTTCA/C/TGAGTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for STAG1 (136055077 - 136305077 bp, first 250kb of STAG1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for STAG1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1391168CNV Deletion17803354
    esv1010377CNV Deletion20482838
    esv271014CNV Insertion20981092
    nsv4026CNV Insertion18451855
    dgv5261n71CNV Loss21882294
    nsv877519CNV Loss21882294
    dgv5260n71CNV Loss21882294
    nsv4025CNV Loss18451855
    nsv520012CNV Loss19592680
    nsv877528CNV Loss21882294

    Human Gene Mutation Database (HGMD): STAG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing STAG1
    DNA2.0 Custom Variant and Variant Library Synthesis for STAG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604358    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for STAG1:
    Cornelia de Lange syndrome

    Find genes that share disorders with STAG1           About GenesLikeMe

    Genetic Association Database (GAD): STAG1
    Human Genome Epidemiology (HuGE) Navigator: STAG1 (1 document)

    Export disorders for STAG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for STAG1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with STAG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. (PubMed id 9305759)1, 2, 3, 9 Carramolino L.... Zipori D. (Gene 1997)
    2. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PubMed id 19936222)1, 4 Chasman D.I....Ridker P.M. (PLoS Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of vertebrate cohesin complexes and their regulation in prophase. (PubMed id 11076961)1, 2 Sumara I.... Peters J.-M. (J. Cell Biol. 2000)
    5. Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. (PubMed id 15361841)1, 9 Anazawa Y....Nakamura Y. (Oncogene 2004)
    6. CTCF physically links cohesin to chromatin. (PubMed id 18550811)1, 9 Rubio E.D.... Krumm A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Protein requirements for sister telomere association in human cells. (PubMed id 17962804)1, 9 Canudas S....Smith S. (EMBO J. 2007)
    8. Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. (PubMed id 24324008)1 Kong X....Yokomori K. (Mol. Cell. Biol. 2014)
    9. Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. (PubMed id 23874961)1 Zhang N....Pati D. (PLoS ONE 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10274 HGNC: 11354 AceView: STAG1 Ensembl:ENSG00000118007 euGenes: HUgn10274
    ECgene: STAG1 Kegg: 10274 H-InvDB: STAG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for STAG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for STAG1 gene:
    Search GeneIP for patents involving STAG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for STAG1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for STAG1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for STAG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for STAG1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for STAG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for STAG1   OriGene Custom Protein Services for STAG1  

     
     
     Block miRNA regulation of human, mouse, rat STAG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing STAG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat STAG1 Predesigned siRNA for gene silencing in human, mouse, rat STAG1
     QuantiFast Probe-based Assays in human, mouse, rat STAG1 QuantiTect SYBR Green Assays in human, mouse, rat STAG1
     Custom PCR Arrays for STAG1 Search Chromatin IP Primers for STAG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat STAG1  GeneGlobe Interaction Network for STAG1
     Regulatory tfbs in STAG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for STAG1 GenScript cDNA clones with any tag delivered in your preferred vector for STAG1
     GenScript Custom Assay Services for STAG1 GenScript Custom overexpressing Cell Line Services for STAG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for STAG1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     STAG1 antibodies
     STAG1 proteins
     STAG1 lysates
     Search for Antibodies for STAG1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for STAG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for STAG1
     Antibodies for STAG1
     ELISAs for STAG1
     CLIAs for STAG1



     Browse ESI BIO Cell Lines and PureStem Progenitors for STAG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAG1
     SwitchGear 3'UTR luciferase reporter plasmids for STAG1
     SwitchGear Promoter luciferase reporter plasmids for STAG1
     ThermoFisher Antibody for STAG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAG1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for STAG1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for STAG1
     LSBio Antibodies in human, mouse, rat for STAG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for STAG1
      Search eBioscience for proteins for STAG1
      Search eBioscience for elisas for STAG1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      STAG1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4