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Aliases for STAG1 Gene

Aliases for STAG1 Gene

  • Stromal Antigen 1 2 3 4
  • SCC3 Homolog 1 3 4
  • SA1 3 4
  • Nuclear Protein Stromal Antigen 1 3
  • Cohesin Subunit SA-1 3
  • SCC3A 3

External Ids for STAG1 Gene

Summaries for STAG1 Gene

Entrez Gene Summary for STAG1 Gene

  • This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAG1 Gene

STAG1 (Stromal Antigen 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is STAG3.

UniProtKB/Swiss-Prot for STAG1 Gene

  • Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

Gene Wiki entry for STAG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAG1 Gene

Genomics for STAG1 Gene

Genomic Location for STAG1 Gene

Start:
136,336,233 bp from pter
End:
136,752,403 bp from pter
Size:
416,171 bases
Orientation:
Minus strand

Genomic View for STAG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAG1 Gene

Regulatory Elements for STAG1 Gene

Proteins for STAG1 Gene

  • Protein details for STAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVM7-STAG1_HUMAN
    Recommended name:
    Cohesin subunit SA-1
    Protein Accession:
    Q8WVM7
    Secondary Accessions:
    • O00539
    • Q6P275

    Protein attributes for STAG1 Gene

    Size:
    1258 amino acids
    Molecular mass:
    144427 Da
    Quaternary structure:
    • Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3.

    Alternative splice isoforms for STAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAG1 Gene

Proteomics data for STAG1 Gene at MOPED

Post-translational modifications for STAG1 Gene

  • Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys273 and Lys366

Other Protein References for STAG1 Gene

No data available for DME Specific Peptides for STAG1 Gene

Domains for STAG1 Gene

Protein Domains for STAG1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

STAG1_HUMAN
Domain:
  • Contains 1 SCD (stromalin conservative) domain.:
    • Q8WVM7
Family:
  • Belongs to the SCC3 family.:
    • Q8WVM7
genes like me logo Genes that share domains with STAG1: view

No data available for Gene Families for STAG1 Gene

Function for STAG1 Gene

Molecular function for STAG1 Gene

UniProtKB/Swiss-Prot Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

Gene Ontology (GO) - Molecular Function for STAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 15855230
genes like me logo Genes that share ontologies with STAG1: view
genes like me logo Genes that share phenotypes with STAG1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for STAG1 Gene

Localization for STAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAG1 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAG1 Gene COMPARTMENTS Subcellular localization image for STAG1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for STAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 16682347
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome TAS --
genes like me logo Genes that share ontologies with STAG1: view

Pathways for STAG1 Gene

genes like me logo Genes that share pathways with STAG1: view

Pathways by source for STAG1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for STAG1 Gene
15 Reactome pathways for STAG1 Gene
1 KEGG pathway for STAG1 Gene

Gene Ontology (GO) - Biological Process for STAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007059 chromosome segregation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0016925 protein sumoylation TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with STAG1: view

Transcripts for STAG1 Gene

Unigene Clusters for STAG1 Gene

Stromal antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STAG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2:
SP3:

ExUns: 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1: -
SP2: - -
SP3:

Relevant External Links for STAG1 Gene

GeneLoc Exon Structure for
STAG1
ECgene alternative splicing isoforms for
STAG1

Expression for STAG1 Gene

mRNA expression in normal human tissues for STAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for STAG1 Gene

SOURCE GeneReport for Unigene cluster for STAG1 Gene Hs.412586

genes like me logo Genes that share expressions with STAG1: view

Orthologs for STAG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for STAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAG1 36
  • 99.84 (n)
  • 99.92 (a)
STAG1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAG1 36
  • 94.97 (n)
  • 99.76 (a)
STAG1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAG1 36
  • 95.31 (n)
  • 99.52 (a)
STAG1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stag1 36
  • 92.95 (n)
  • 99.36 (a)
Stag1 16
Stag1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAG1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STAG1 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Stag1 36
  • 93.38 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves STAG1 36
  • 85.49 (n)
  • 96.82 (a)
STAG1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAG1 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3441 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158523 36
  • 79.04 (n)
  • 90.6 (a)
zebrafish
(Danio rerio)
Actinopterygii stag1a 36
  • 75.16 (n)
  • 86.9 (a)
stag1a 37
  • 85 (a)
OneToMany
stag1b 37
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006998 36
  • 53.66 (n)
  • 51.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta SA 36
  • 52.47 (n)
  • 49.7 (a)
SA 37
  • 44 (a)
ManyToMany
SA-2 37
  • 24 (a)
ManyToMany
CG13916 38
  • 22 (a)
SA 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea scc-3 37
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRR1 37
  • 18 (a)
OneToMany
IRR1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons SCC3 36
  • 41.37 (n)
  • 27.7 (a)
rice
(Oryza sativa)
Liliopsida Os05g0188500 36
  • 40.69 (n)
  • 25.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for STAG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAG1 Gene

ENSEMBL:
Gene Tree for STAG1 (if available)
TreeFam:
Gene Tree for STAG1 (if available)

Paralogs for STAG1 Gene

Paralogs for STAG1 Gene

genes like me logo Genes that share paralogs with STAG1: view

Variants for STAG1 Gene

Sequence variations from dbSNP and Humsavar for STAG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8045 -- 136,336,617(-) CCCAG(A/G)ATTGT utr-variant-3-prime
rs13785 -- 136,336,490(+) CACGC(A/G)AAGGA utr-variant-3-prime
rs474494 -- 136,356,483(+) caagc(A/G)attct intron-variant
rs475318 -- 136,356,518(+) tggga(C/T)tacag intron-variant
rs477142 -- 136,341,297(+) CTCAC(A/G)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAG1 Gene

Variant ID Type Subtype PubMed ID
nsv4025 CNV Loss 18451855
nsv877519 CNV Loss 21882294
dgv5260n71 CNV Loss 21882294
nsv877522 CNV Loss 21882294
nsv520012 CNV Loss 19592680
nsv238089 CNV Loss 16902084
dgv5261n71 CNV Loss 21882294
nsv877528 CNV Loss 21882294
nsv460861 CNV Loss 19166990
nsv4026 CNV Insertion 18451855
esv271014 CNV Insertion 20981092
nsv877529 CNV Gain 21882294
esv1010377 CNV Deletion 20482838
esv1391168 CNV Deletion 17803354

Relevant External Links for STAG1 Gene

HapMap Linkage Disequilibrium report
STAG1
Human Gene Mutation Database (HGMD)
STAG1

Disorders for STAG1 Gene

(1) University of Copenhagen DISEASES for STAG1 Gene

Relevant External Links for STAG1

Genetic Association Database (GAD)
STAG1
Human Genome Epidemiology (HuGE) Navigator
STAG1
genes like me logo Genes that share disorders with STAG1: view

No data available for UniProtKB/Swiss-Prot for STAG1 Gene

Publications for STAG1 Gene

  1. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. (PMID: 9305759) Carramolino L. … Zipori D. (Gene 1997) 2 3 4 23
  2. Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. (PMID: 15361841) Anazawa Y. … Nakamura Y. (Oncogene 2004) 3 23
  3. Characterization of vertebrate cohesin complexes and their regulation in prophase. (PMID: 11076961) Sumara I. … Peters J.-M. (J. Cell Biol. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman D.I. … Ridker P.M. (PLoS Genet. 2009) 3 49

Products for STAG1 Gene

Sources for STAG1 Gene

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