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Aliases for STAC3 Gene

Aliases for STAC3 Gene

  • SH3 And Cysteine Rich Domain 3 2 3
  • NAM 3 6
  • SH3 And Cysteine-Rich Domain-Containing Protein 3 3

External Ids for STAC3 Gene

Previous GeneCards Identifiers for STAC3 Gene

  • GC12M055924
  • GC12M055925
  • GC12M057637
  • GC12M054676

Summaries for STAC3 Gene

Entrez Gene Summary for STAC3 Gene

  • The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]

GeneCards Summary for STAC3 Gene

STAC3 (SH3 And Cysteine Rich Domain 3) is a Protein Coding gene. Diseases associated with STAC3 include native american myopathy. GO annotations related to this gene include identical protein binding. An important paralog of this gene is STAC.

UniProtKB/Swiss-Prot for STAC3 Gene

  • In skeletal muscles contraction, may play a role in neuromuscular synaptic transmission.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC3 Gene

Genomics for STAC3 Gene

Regulatory Elements for STAC3 Gene

Genomic Location for STAC3 Gene

57,243,453 bp from pter
57,251,193 bp from pter
7,741 bases
Minus strand

Genomic View for STAC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for STAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC3 Gene

Proteins for STAC3 Gene

  • Protein details for STAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 and cysteine-rich domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DUK9
    • Q96HU5

    Protein attributes for STAC3 Gene

    364 amino acids
    Molecular mass:
    41507 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STAC3 Gene

    Alternative splice isoforms for STAC3 Gene


neXtProt entry for STAC3 Gene

Proteomics data for STAC3 Gene at MOPED

Post-translational modifications for STAC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC3 Gene

No data available for DME Specific Peptides for STAC3 Gene

Domains for STAC3 Gene

Protein Domains for STAC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 SH3 domains.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
  • Contains 2 SH3 domains.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with STAC3: view

No data available for Gene Families for STAC3 Gene

Function for STAC3 Gene

Molecular function for STAC3 Gene

UniProtKB/Swiss-Prot Function:
In skeletal muscles contraction, may play a role in neuromuscular synaptic transmission.

Gene Ontology (GO) - Molecular Function for STAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAC3: view
genes like me logo Genes that share phenotypes with STAC3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STAC3 Gene

Localization for STAC3 Gene

Subcellular locations from

Jensen Localization Image for STAC3 Gene COMPARTMENTS Subcellular localization image for STAC3 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for STAC3 Gene

Pathways for STAC3 Gene

SuperPathways for STAC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IMP 23736855
GO:0007274 neuromuscular synaptic transmission IMP 23736855
GO:0035556 intracellular signal transduction IEA --
GO:0048741 skeletal muscle fiber development IEA --
genes like me logo Genes that share ontologies with STAC3: view

No data available for Pathways by source for STAC3 Gene

Drugs for STAC3 Gene

(1278) HMDB Compounds for STAC3 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Myristoyl-3-myristoyl-sn-glycerol
  • 1-Myristoyl-3-myristoleoyl-sn-glycerol
  • 1-Myristoyl-3-pentadecanoyl-sn-glycerol
  • 1-Myristoyl-3-palmitoyl-sn-glycerol
  • 1-Myristoyl-3-palmitoleoyl-sn-glycerol
genes like me logo Genes that share compounds with STAC3: view

Transcripts for STAC3 Gene

Unigene Clusters for STAC3 Gene

SH3 and cysteine rich domain 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for STAC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP2: - - - - -
SP3: -

Relevant External Links for STAC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STAC3 Gene

mRNA expression in normal human tissues for STAC3 Gene

mRNA differential expression in normal tissues according to GTEx for STAC3 Gene

This gene is overexpressed in Muscle - Skeletal (47.2).

SOURCE GeneReport for Unigene cluster for STAC3 Gene Hs.417595

genes like me logo Genes that share expressions with STAC3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for STAC3 Gene

Orthologs for STAC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STAC3 35
  • 93.74 (n)
  • 96.96 (a)
STAC3 36
  • 96 (a)
(Canis familiaris)
Mammalia STAC3 35
  • 93.76 (n)
  • 96.69 (a)
STAC3 36
  • 91 (a)
(Mus musculus)
Mammalia Stac3 35
  • 90.34 (n)
  • 93.59 (a)
Stac3 16
Stac3 36
  • 89 (a)
(Pan troglodytes)
Mammalia STAC3 35
  • 99.82 (n)
  • 99.45 (a)
STAC3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Stac3 35
  • 90.65 (n)
  • 94.17 (a)
(Anolis carolinensis)
Reptilia STAC3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stac3 35
  • 73.71 (n)
  • 81.07 (a)
(Danio rerio)
Actinopterygii stac3 35
  • 66.98 (n)
  • 66.98 (a)
stac3 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43729 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for STAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAC3 Gene

Gene Tree for STAC3 (if available)
Gene Tree for STAC3 (if available)

Paralogs for STAC3 Gene

Paralogs for STAC3 Gene

(3) SIMAP similar genes for STAC3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STAC3: view

Variants for STAC3 Gene

Sequence variations from dbSNP and Humsavar for STAC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3204635 -- 57,243,810(-) TTAGG(C/T)GTGCG utr-variant-3-prime, nc-transcript-variant
rs7133915 -- 57,247,557(+) GCCTC(C/T)CCGAG intron-variant
rs7139342 -- 57,245,407(+) ccctc(C/T)gtcac intron-variant
rs7976512 -- 57,249,903(+) GGTGC(A/G)CACTA intron-variant
rs10876968 -- 57,250,984(+) AAGAG(G/T)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STAC3 Gene

Variant ID Type Subtype PubMed ID
dgv96n21 CNV Loss 19592680
nsv519293 CNV Loss 19592680

Relevant External Links for STAC3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC3 Gene

Disorders for STAC3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for STAC3 Gene in MalaCards »

(1) Disease for STAC3 Gene

(1) OMIM Diseases for STAC3 Gene (615521)


  • Native American myopathy (NAM) [MIM:255995]: A disease characterized by congenital weakness and arthrogryposis, cleft palate, ptosis, short stature, kyphoscoliosis, talipes deformities, and susceptibility to malignant hyperthermia provoked by anesthesia. {ECO:0000269 PubMed:23736855}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with STAC3: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for STAC3 Gene

Publications for STAC3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. (PMID: 23736855) Horstick E.J. … Kuwada J.Y. (Nat Commun 2013) 3 4
  4. Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. (PMID: 23818578) Nelson B.R. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for STAC3 Gene

Sources for STAC3 Gene

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