STAC3 Gene
protein-coding GIFtS: 46
GCID: GC12M057637
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SH3 and cysteine rich domain 3
| |
Aliases
for STAC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3 And Cysteine Rich Domain 31 2 | | MGC27931 | | SH3 And Cysteine-Rich Domain-Containing Protein 32 |
Export aliases for STAC3 gene to outside databasesPrevious GC identifers: GC12M055924 GC12M055925 GC12M054676 |
Summaries
for STAC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for STAC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STAC3 gene promoter:
Nkx3-1 Elk-1 Nkx3-1 v4 Spz1 HOXA3 Nkx3-1 v1 Evi-1 Nkx3-1 v2 HOXA5 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for STAC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.2STAC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M057637: view genomic region
(about GC identifiers)
Start:
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57,637,236 bp from pter |
End:
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57,644,976 bp from pter |
Size:
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7,741 bases |
Orientation:
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minus strand |
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Proteins
for STAC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STAC3_HUMAN, Q96MF2 (See
protein sequence)Recommended Name: SH3 and cysteine-rich domain-containing protein 3 Size: 364 amino acids; 41507 Da
1 PDB 3D structure from  and Proteopedia  for STAC3:2DB6 (3D)
Secondary accessions: Q96HU5Alternative splicing: 2 isoforms: Q96MF2-1 Q96MF2-2 Explore the universe of human proteins at neXtProt for STAC3: NX_Q96MF2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MF2
STAC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659501.1
ENSEMBL proteins: ENSP00000452068 ENSP00000329200 ENSP00000450740 ENSP00000441515 ENSP00000452299
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
STAC3 for ontologies About GeneDecksing
STAC3 Antibody Products:
Assay Products for STAC3: |
Protein
Domains /
Families
for STAC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STAC3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MF2ProtoNet protein and cluster: Q96MF2 2 Blocks protein families: IPB001452 SH3 domain signature IPB011511 Variant SH3
UniProtKB/Swiss-Prot: STAC3_HUMAN, Q96MF2Similarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 2 SH3 domains |
Function
for STAC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: STAC3 (NM_145064) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
STAC3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for STAC3:
|
Pathways & Interactions
for STAC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for STAC3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for STAC3 (Q96MF21, 2, 3 ENSP000003292004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035556 | intracellular signal transduction |
IEA | -- |
STAC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for STAC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for STAC3
10/843 HMDB Compounds for STAC3 (see all 843) About this table
Search CenterWatch for drugs/clinical trials and news about STAC3
|
Transcripts
for STAC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for STAC3 gene: NM_145064.1 Unigene Cluster for STAC3: SH3 and cysteine rich domain 3 Hs.417595 [show with all ESTs]Unigene Representative Sequence: AK0570137 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000554578 ENST00000332782(uc009zpl.2 uc001snp.2 uc001snq.2 uc010srm.1)
ENST00000557176 ENST00000546246 ENST00000554003 ENST00000553489 ENST00000553294
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: STAC3 (NM_145064) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for STAC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC3 |
Additional cDNA sequence: AK057013.1 AK300688.1 AK311513.1 BC008069.2 7 DOTS entries: DT.92420434 DT.40117610 DT.97837688 DT.91710241 DT.100646867 DT.92420432 DT.95272720 24/62 AceView cDNA sequences (see all 62): AK057013 CD367060 AW410547 BE294470 NM_145064 AA192831 BM716925 BC008069 AW410140 F31205 BM713044 AW249168 BF893514 AW248352 BE296948 BF309526 BF002301 BE295569 AW247926 BF305544 BG828884 BF308707 AI457719 AA192755
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for STAC3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for STAC3
|
Expression
for STAC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| STAC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGAGGAGG
About this image
See STAC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for STAC3
SOURCE GeneReport for Unigene cluster: Hs.417595
SABiosciences Custom PCR Arrays for STAC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat STAC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC3 |
Orthologs
for STAC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for STAC3 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for STAC3 (if available)
TreeFam Gene Tree for STAC3 (if available) |
Paralogs
for STAC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for STAC3 gene
- STAC2 STAC22
3 SIMAP similar genes for STAC3 using alignment to 4 protein entries: STAC3_HUMAN (see all proteins):STAC ARHGEF7 STAC2
STAC3 for paralogs About GeneDecksing
|
Genomic Variants
for STAC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for STAC3 (57637236 - 57644976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STAC3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAC3 |
|
Disorders
/ Diseases
for STAC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for STAC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for STAC3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with STAC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for STAC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing STAC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STAC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STAC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for STAC3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for STAC3 gene:
Search GeneIP for patents involving STAC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STAC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for STAC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for STAC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for STAC3 | | | OriGene Protein Over-expression Lysate for STAC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for STAC3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for STAC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for STAC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat STAC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing STAC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat STAC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat STAC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat STAC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat STAC3 |
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 |  |  |  | |
| | | | Search Tocris compounds for STAC3 |
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 | | | STAC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for STAC3 |
|  |  |  | | | | Search ThermoFisher Antibodies for STAC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat STAC3 |
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